LOCUS       NZ_BNBR01000001        24895 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces griseosporeus strain JCM 4766 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBR01000001
VERSION     NZ_BNBR01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces griseosporeus
  ORGANISM  Streptomyces griseosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 2104813)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 112X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014656055.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:04:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,365
            CDSs (total)                      :: 7,282
            Genes (coding)                    :: 7,186
            CDSs (with protein)               :: 7,186
            Genes (RNA)                       :: 83
            rRNAs                             :: 2, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 41 of 96
            Pseudo Genes (incomplete)         :: 61 of 96
            Pseudo Genes (internal stop)      :: 11 of 96
            Pseudo Genes (multiple problems)  :: 15 of 96
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 633757
            Orig. end                         :: 658652
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBR01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24895
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24895
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22583
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22583
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12583](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12583
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(907..1407)
                     /locus_tag="IE308_RS02845"
                     /old_locus_tag="GCM10018783_06020"
     CDS             complement(907..1407)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389408.1"
                     /locus_tag="IE308_RS02845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06020"
                     /product="metallophosphoesterase"
                     /protein_id="WP_110634650.1"
                     /sec_met_domain="Metallophos_2 (E-value: 9.5e-26, bitscore:
                     87.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLLTTDTHLPKRARQLPAPLLAELPRADVVFHAGDWVDTATLD
                     LFEEHSRRLIGVYGNNDGPELRARLPEVAYADLGGLRFGAVHETGPAQGREARCAARFP
                     DLDVLVFGHSHIPWDTTAPGGLRLLNPGSPTDRRRQPYCTYMTATVADGRLTDVELHRL
                     PPR"
     gene            complement(1438..2400)
                     /gene="rfbB"
                     /locus_tag="IE308_RS02850"
                     /old_locus_tag="GCM10018783_06030"
     CDS             complement(1438..2400)
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-177). E-value: 1.3e-19.
                     Score: 62.3. Matches aSDomain:
                     nrpspksdomains_IE308_RS02850_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380948.1"
                     /locus_tag="IE308_RS02850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06030"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_190216437.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.1e-15, bitscore:
                     53.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.8e-20,
                     bitscore: 70.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.8e-18, bitscore:
                     62.3, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLLVTGAAGFIGSAYVRTLLARPEPPHITVLDKLTYAGTPDNLP
                     QDHPRLRFVRGDICDAGLVDRLMAEADQVVHFAAESHVDRSIEGAGDFVRTNVLGTQTL
                     LDAALRHGTGPFVHVSTDEVYGSVPSGSCTEEAPLRPTSPYAASKASSDLLALACHRTH
                     GLDVRVTRCSNNYGPRQFPEKVVPLFVTHLLEGRPVPLYGDGRNVRDWLHVDDHCHGVE
                     LVRTQGRPGEIYNLGGGTELSNRELTSLLLDALGCGWDMVEHVTDRKAHDLRYSVDWSK
                     ARRELGYRPRRDLASGLAETVAWYREHRDWWEPLKARLG"
     aSDomain        complement(1870..2388)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE308_RS02850_NAD_binding_4.1"
                     /evalue="1.30E-19"
                     /label="IE308_RS02850_NAD_binding_4.1"
                     /locus_tag="IE308_RS02850"
                     /protein_end="177"
                     /protein_start="4"
                     /score="62.3"
                     /tool="antismash"
                     /translation="VTGAAGFIGSAYVRTLLARPEPPHITVLDKLTYAGTPDNLPQDHP
                     RLRFVRGDICDAGLVDRLMAEADQVVHFAAESHVDRSIEGAGDFVRTNVLGTQTLLDAA
                     LRHGTGPFVHVSTDEVYGSVPSGSCTEEAPLRPTSPYAASKASSDLLALACHRTHGLDV
                     RVTRCSNNYG"
     gene            complement(2451..2630)
                     /locus_tag="IE308_RS02855"
                     /old_locus_tag="GCM10018783_06040"
     CDS             complement(2451..2630)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134767.1"
                     /locus_tag="IE308_RS02855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06040"
                     /product="hypothetical protein"
                     /protein_id="WP_110634644.1"
                     /transl_table=11
                     /translation="MTPQAKEKSPIRRPETGWARARRLRREHALRTWMPAVEEPGGPPA
                     LQSGGDAHIVRGED"
     gene            complement(2711..3073)
                     /locus_tag="IE308_RS02860"
                     /old_locus_tag="GCM10018783_06050"
     CDS             complement(2711..3073)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988037.1"
                     /locus_tag="IE308_RS02860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06050"
                     /product="DUF6479 family protein"
                     /protein_id="WP_190216438.1"
                     /transl_table=11
                     /translation="MNSTLYLAASAGTAFGVVAVLVAGVLITAGLIWAVRLGIGVRRRE
                     HRPPRPEEQPRLPDSGPVRESHEMRAPHEMPRTDGERLTPHELRPTGGAPSGDQERGRW
                     SEGSSGSFGSGGSGGA"
     gene            3202..4875
                     /gene="ctaD"
                     /locus_tag="IE308_RS02865"
                     /old_locus_tag="GCM10018783_06060"
     CDS             3202..4875
                     /EC_number="7.1.1.9"
                     /GO_function="GO:0004129 - cytochrome-c oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0015990 - electron transport coupled proton
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ctaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327999.1"
                     /locus_tag="IE308_RS02865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06060"
                     /product="cytochrome c oxidase subunit I"
                     /protein_id="WP_190216439.1"
                     /transl_table=11
                     /translation="MTQLSARGTEEPGHTGGRRSAAAALLEWTSTTDHKVIGRLYMVTS
                     FCFFLLAGLLALAMRAELARPGLQLLNRDGYNQFVTVHGTIMMLLFATPMFAGFANAVM
                     PLQIGAPDVAFPRLNALSYWMYLFGGLIVVSGFLVPGGAASFGWFAYAPLNSAYHTPGA
                     GADLWAMGLVVSGVSTTLTAVNFIATIMCLRAPGMTMFRMPLFTWNVLFTSILVLPAFP
                     VLTAALLALEADRKFGAHVFDAANGGALLWQHLFWFFGHPEVYIVALPFFGIVSEIIPV
                     FSRKPLWGYLPLIGATITITMLSAVVWAHHMFATGAVLLPFFSLMSFLIAVPTGIKFFA
                     WVGTMTRGSLSFETPMLWSLGFMVSFLLGGLSGVLIASPPLDFHLTDSYFIVAHLHYVL
                     FGTVVFAMFAGFYFWWPKFTGKHLDEWLGKLHFWLLFPGFQLTFLVQHWLGEAGMPRRY
                     ADYLPADGFTLLNTLSTAGAFLLGVSTLPFLYNVWRTSRRPRTVDVDDPWGWGRSLEWA
                     TSCPPPRHNFLALPRVRSESPAFDLHHPWPARRAREAGQR"
     gene            4872..5273
                     /locus_tag="IE308_RS02870"
                     /old_locus_tag="GCM10018783_06070"
     CDS             4872..5273
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004129 - cytochrome-c oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0022900 - electron transport chain
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971910.1"
                     /locus_tag="IE308_RS02870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06070"
                     /product="cytochrome c oxidase subunit 4"
                     /protein_id="WP_190216440.1"
                     /transl_table=11
                     /translation="MKAESLLFGGVALFFAGIAALYGGWSAEPAGTAVLVVAFLMAAVV
                     SFFSAVQYRRRGVRPQDRGDAEVAEAAGPVEFFPPESRWPVVTAAGFALAATGVVFGLW
                     LFLIGAAVLARGVLGLVFQYADRDSGRPE"
     gene            complement(5191..6738)
                     /locus_tag="IE308_RS02875"
                     /old_locus_tag="GCM10018783_06080"
     CDS             complement(5191..6738)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003861.1"
                     /locus_tag="IE308_RS02875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06080"
                     /product="ubiquinol-cytochrome c reductase cytochrome b
                     subunit"
                     /protein_id="WP_190216441.1"
                     /transl_table=11
                     /translation="MARERPPEAASGAAARPRRGERLADATDARLPVTEGGALLRKAFP
                     DHWSFLLGEIALYSLVVLLLTGVWLTFFFDPEMREVVYAGRYVPLRGIRMSAAYESTLR
                     LSFDVRGGLLLRQAHHWAALVFAAAIGTHLLRVFFTGAFRRPRELNWVIGVTLFALALA
                     EGFAGYSLPDDLLSGTGLRIAQGIMLSLPVVGTYVAFFVFGGQFPGLDFISRLYGVHIL
                     LLPGAILALVTAHLILVFHLKHTQWRGPGRTVRNAVGKPMFPQFAATSAGLFCTVFGVL
                     AALGGLAQVNPVWVYGPYRPDQASTGSQPDFYVGFLEGALRLVPPWETNLAGHTLMWNV
                     LLPAVVLPGLLFLVLYGYPFAEQRLTGEGGREHHLCDRPRERPVRTALGVAGITFYGVL
                     LLAGANDVVAATFRISVDAMTWTLRIALVVAPVLAFLLTRGLCHALLDTEQERLRDGVE
                     TGEVRQTVEGGYEESRRPVTDVRPGAPRPPLTPAGPSPGRRTGTPAPEHPGPAPRHR"
     gene            complement(6884..7303)
                     /locus_tag="IE308_RS02880"
                     /old_locus_tag="GCM10018783_06090"
     CDS             complement(6884..7303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117176.1"
                     /locus_tag="IE308_RS02880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06090"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_190216442.1"
                     /transl_table=11
                     /translation="MTQHVRDIMTADPVTVEPQASVTQVARIMRDEDLGAVLVTDGDDL
                     RGLVTDRDLVVRALAEGGDPEQTTVAGACSDDLVTVGPDDELDVAIRLMREHSVRRIPV
                     VDHGHPVGIVSLGDAAMERDPGSALGDISVARPNT"
     gene            complement(7370..9805)
                     /locus_tag="IE308_RS02885"
                     /old_locus_tag="GCM10018783_06100"
     CDS             complement(7370..9805)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019068579.1"
                     /locus_tag="IE308_RS02885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06100"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_190216443.1"
                     /transl_table=11
                     /translation="MVSEGAAGRRTGTPRVEAALQTLMADPDSPERVHGVLECALVFAG
                     AGVAALYAPGDDAELLCLVDAAGLPRTLYGLRGTYALNGDSPAARAHREARAVWLGPRE
                     LAARAPSRRTPAKEFSLAALPVRGGCLVAVSERPGGFDAEARASLERLADAVAAPAPDE
                     PAARGELRTNAFSLAMDSGRIEVGDDILQLFGLSRERFDGKVETLLGLTVPEDLPSLMS
                     VVEADHMSLGDRELEFRVLQPAGPPRWLRLHGRLVPGGEGRPARLVGTVADASTLRSDV
                     TDVARVQRLAAALSTAGTVRDVSQAVVSALRRPLRADRIALAELEGDRLVVTVLDPPDP
                     EAWPELWRREWRTEWPDAPVRTMPTLAAALREGRARIWPAGTALEPALADVGPGGLAVL
                     PLPAAGRMAGACLIGWDTPHDFGPDERALLTASAGLAGQALMRAHAFDAEHELVGMLQR
                     QLLPRRLPQLPGAVAVARYLPATAGLEVGGDWYDVIPLPDNRVALVIGDVQGHSTAAAT
                     LMGQMRTALRAYAAEGHPPDVVVAHANRLLADLETDLFATCCYVEVDMESGSAWSVRAG
                     HLPPVLRHPDGRTEIVETDGGPPLGVLRQAEFPLGPLALRPGTVVALTTDGLVESADAD
                     IDQGLARFAGELGAADPADLGPVADALLGGARRSDDIALLLMRYDGMASRPLRESWTVW
                     RVPQAVGQARRFTRRTLRSWNVPERDRDAVLLVVSELVTNALVHTDGRVRLDLTLVNHR
                     LRVAVADASPRSPVKPTSIGWEATGGRGILLVEALSDSWGTVPVSGGKQVWSELALGR"
     gene            10001..12583
                     /gene="lanKC"
                     /locus_tag="IE308_RS02890"
                     /old_locus_tag="GCM10018783_06110"
     CDS             10001..12583
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128990.1"
                     /locus_tag="IE308_RS02890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06110"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_190216444.1"
                     /sec_met_domain="micKC (E-value: 4.3e-232, bitscore: 769.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 3.6e-11, bitscore: 39.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.6e-07, bitscore:
                     25.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYEVYALADRHFYDTPDRTAGAAEAAAPLLEAARRAVPEGWE
                     AARTGDWLTLTPLGADGRPQPGPAQGWKVHSSATPANAERIAAIVWDYCVPRRIPFKFV
                     PAAHLVHLRNAKYATRDTSGKFVTLYPDGEEQLHTVLRELGELLAGFEGPYILTDLRWG
                     DGPLHVRYGAFARAYVVDERGALVPAVRDGEGRLVPDRRTPSFQVPEWVTLPEFLQPHL
                     AARNTTTVGELPYRIDKALHFSNGGGVYAGTDTRTGRKVVLKEGRPHAGLAADGADAVT
                     RLERERQALERLSGTGVVPEVRDWFTLGDHRFLVTDFVEGKPLNAFFAERHPLLTPDPD
                     PAEVAAYTRWAVRIHRAVEQAVEQVHARGIVFNDLHVFNIMVAPDEESVLLLDFEAAAP
                     AEERGRQVVAHPGFFAPPDRRGTDVDRYALACLRLALFLPVTTLFVVDRGKAAHLAEVI
                     AGQFPDLPEGFLAEAVAEITRSAGDEPSGIRPGAAPLVDPADWPYSRDSMVKAILASAT
                     PERDDRLFPGDIAQFSDGGGLGLAHGAAGVLYALAAADGIRYEEGERWLLAHTDPAPPG
                     TPLGLYDGLAGVAHVLDLLGHRQRALDLVEGILTERWQNLPSDLHGGLAGLGLVLAHLA
                     DTTGESALGRRADEAARILLGRLAEPAAPKRRAGLLRGASGPALFLLRQYERNGDRTLL
                     DGAAVALRRDLERCVVRPGGSLEVDEGWRTLPYLGDGSAGVGMVLDDFLALSGDRDGGW
                     AEARAGILTAASARFYAQPGLFQGRAGLILHLHRTGDPDGRLSGQIAGLGWYAMAYQGQ
                     LAFPGHQMMRLSMDLATGTAGCLLALTAALDGPDAAHLPFLPPPRRPS"
     gene            12666..12782
                     /locus_tag="IE308_RS02895"
     CDS             12666..12782
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983510.1"
                     /locus_tag="IE308_RS02895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_028798592.1"
                     /transl_table=11
                     /translation="MALLDLQTMESDEHTGGGGASTVSLLSCISAASVLLCL"
     CDS_motif       12666..12728
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQTMESDEHTGGGGAS"
                     /locus_tag="IE308_RS02895_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12729..12782
                     /prepeptide="core"
                     /locus_tag="IE308_RS02895_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="27.40"
                     /molecular_weight="1603.0"
                     /monoisotopic_mass="1601.9"
                     /core_sequence="TVSLLSCISAASVLLCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQTMESDEHTGGGGAS"
                     /leader_location="[12665:12728](+)"
                     /alternative_weights="1621.0"
                     /alternative_weights="1639.0"
                     /alternative_weights="1657.0"
     gene            12884..14617
                     /locus_tag="IE308_RS02900"
                     /old_locus_tag="GCM10018783_06120"
     CDS             12884..14617
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471139.1"
                     /locus_tag="IE308_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06120"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190216445.1"
                     /transl_table=11
                     /translation="MRPRWQDDPLTRESRALLRSAGRHSAARCAALCLVTATATGAELL
                     LPAALGRALDLLLAQAPATRWVLCCAALVLLVAALGTAETVLHGTVDARATAWLRRRTL
                     AQVLAAGPRTGDRFGSGDLVARLVGNAAQAGAAPAARAALLAALAGPVGGVVALALIDP
                     WLAVVFLAGAPLLALLLRALARDVSACVADYQRVQGRIAGALAEAVAGRRTLRAAGLEA
                     KETARILRPLPELSRAGREMWRVQGRAAAQAVAVAPLLQLGVIAVAGLLLARHRLSAGD
                     VLAASRYAVLATGVGVLVGQLSGLARSRTAAQRLGELHTVPAPDHGERRLPAGGPGRLE
                     FRRVTALRGDRTVLTGVDLVVPGGTTLAVVGRSGTGKSLLAALAARLADPDDGEILLDG
                     VPLPELSRRELRAAVACAFDRPVLLGDTVGDAIGLGLPGPSPALVREAARTAHADDFVR
                     RLPDGYATVCADAPRSGGESQRLGLARAFARRARLLVLDDALSSLDTVTEHRITQALLA
                     PGARGTRLVVAHRAATAARADAVVWLDDGRVRAVGRHAALWREAGYRAVFGVPTGEESD
                     T"
     cand_cluster    14680..24895
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    14680..24895
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[19679:19895](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      19680..19895
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            14719..16557
                     /locus_tag="IE308_RS37300"
                     /old_locus_tag="GCM10018783_06130"
     CDS             14719..16557
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378093.1"
                     /locus_tag="IE308_RS37300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06130"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_308440088.1"
                     /transl_table=11
                     /translation="MGQTFLLGYALARALDEGFLAGRPGTGLGWLAVAGAGVVVGAYGT
                     GRVYGAVAALVEPLRDRLVERVVARGVREADDGALSGLTQQVEIARDTFAGLVMVSRSF
                     VFTAAGALVGLFSLAPPLLLVVLPPLAVGVALFAVTLRPLARRQEAYLVADEALAARLG
                     AVCPGLRDITATGAEDVIGADLAVYVEAEERAARALARWSVVRVASLAVGGQFPAVLLL
                     ATAPWLLAHGVTAGALVGALAYVTQSLLPALRNLVHGLGTGGSRLAVVLRRLTGAEGQP
                     GEAEEADGQAGKGTPAPDRPASRTVTSPGRPASRTVPAPPSPPPPALRLSGVTFAHGPH
                     AEPVLQGLDLDLPDGGHLAVVGPSGTGKSTLTLLAAGLLRPGSGTVTVYGDPAGARAAA
                     ARRVLIPQEAYVHTGTLAENLSLLRPGPVPRRELLAAAEAVGLTPLLERLGGPEAVVDP
                     AALSAGERQLIALTRAYLSYAPLALLDEATCHLDPEAEERAERAFAARPGGTLLVVAHR
                     ITSARRAQRVLVMDGPRTAYGGHEELLDRSPGYRELVGHWDPASQPALALGDADGVDAV
                     AGAGLAGDGRHVVAHGPVGQVQRPRDLGDGGALGGE"
     gene            complement(<16483..17115)
                     /locus_tag="IE308_RS02910"
                     /pseudo=""
     CDS             complement(<16483..17115)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="IE308_RS02910"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="response regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAGSSRPRTVTRVNNGAGAEHHACRAPRTPAKRAEGAAVIRVLLV
                     HDASLVRSVLTDWLHRAPDLRVEGSCWDEAAARVAAVRPDVCAADLEWSGAHGLPPLGD
                     LRARGRDRARLLVLATANRPGLLRHAMEAGAVGFVDKEGSPDRLLRGIRRLAEGERFVD
                     DSLGFGFLKAAEMPLTRRELSVLSLAAEGASVAEIAGSLHLSHGTVRN"
     misc_feature    complement(16669..16671)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(16672..16674)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17074..17089)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            complement(17286..18677)
                     /locus_tag="IE308_RS02915"
                     /old_locus_tag="GCM10018783_06140"
     CDS             complement(17286..18677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016430713.1"
                     /locus_tag="IE308_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06140"
                     /product="S1 family peptidase"
                     /protein_id="WP_190216446.1"
                     /transl_table=11
                     /translation="MSHKRIPKRKAAIAAGGVAALGAAAILLPNANASQDGASDASAAP
                     RTLKSTDASDLAAQLSNLLGDAFAGSYYDAGKQQLVVNVVPGDDNNVIIQAKKAGAAVR
                     EVDNSLAELKAGAQTLKRKATIPGTAWAVDPRTDKILVTADSTVTGAKWNRLESAVRGL
                     GSGMATLKKSAGTFKTFVSGGDAIFGGGARCSLGFNVTASDGSPAFLTAGHCGVAAQQW
                     SDSQNGQPIATVDQAVFPGNGDFALVKYDDPNTQAPSEVNVGGGQTVQIAQAADATVGQ
                     QVFRMGSTTGLHDGQVLGLDATVNYPEGTVTGLIQTDVCAEPGDSGGSLFTQDGLAVGL
                     TSGGSGDCTSGGETFFQPVTTALQATGATLGAGGGQAGGGQEQGAGQEQGAGQEQGAGQ
                     DQGAGQEPGGEQAGGGDAGAGAGDQAGAGDGSDTGDDTGDGMGAGGHAGAGGAEEGNSG
                     LTETH"
     misc_feature    complement(18775..18786)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            18867..19280
                     /locus_tag="IE308_RS02920"
                     /old_locus_tag="GCM10018783_06150"
     CDS             18867..19280
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676669.1"
                     /locus_tag="IE308_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06150"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_110634613.1"
                     /transl_table=11
                     /translation="MTMTTAEADKILADNFAPWVLDLGLSVQAVGDDRALLRLPWSDRL
                     AREGGALSGQALMAAADTATVIAVSAARGAYGPMTTVQQSTTFQRAVTGSDVLVQAVVT
                     KLGRRTAFADITLVDEASGELAAHASTVYALLG"
     misc_feature    complement(19487..19502)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.78"
                     /tool="antismash"
     gene            19680..19895
                     /locus_tag="IE308_RS02925"
                     /old_locus_tag="GCM10018783_06160"
     CDS             19680..19895
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="IE308_RS02925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06160"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_110634610.1"
                     /sec_met_domain="strepbact (E-value: 2.2e-36, bitscore:
                     121.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVQTAEISDAELDNVSGGLSINAVNTVTGAVNGVAPVGGL
                     LDTVVGTVEGVTGLNTAPVTNLVAGL"
     misc_feature    19694..19709
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 18.93"
                     /tool="antismash"
     gene            19990..20796
                     /locus_tag="IE308_RS02930"
                     /old_locus_tag="GCM10018783_06170"
     CDS             19990..20796
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IE308_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06170"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_190216447.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRLARPQGWLVLAVTGAAMAAASVW
                     AVTGSVTSTVSAPAILTHGEGSYILQSPAAGQVTAVLAKEGERLPAGAPVLKVRTAEGE
                     TVVRTVAAGRITALAATIGQIIATGANVAAVEKVAHPGDPLYATVYVPAETAASIPAHA
                     TVDLTVQTVPAERYGVLRGHVQSVDRTAQSARQIAAFLGDSQLGEQFTEQGRPVAVTVR
                     LDTSAATRSGYRWSSAGGPPYALTSMTLATGAIRLADQRPVDWLLP"
     gene            20793..23018
                     /locus_tag="IE308_RS02935"
                     /old_locus_tag="GCM10018783_06180"
     CDS             20793..23018
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040519.1"
                     /locus_tag="IE308_RS02935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018783_06180"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_190216448.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.8e-39, bitscore:
                     129.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAAPETRGRRRAAPPKRSVPKARGKAVRTQSVLQMEAVECGAA
                     SLAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARSYGLTAKGMQMDLAALAEVA
                     APAILFWEFNHYVVYDGMGRRFGRRGVFVNDPAKGRRFVPLEDFDGSFTGVVLVMEPGE
                     DFVRGGRKPGVWGAMPARLRGTAGTLPAAVLASLLLVLVGAAVPALSRTYIDMFLIGGQ
                     TSLLGVLFAAMAACVALTVALTWLQQANLHHGRIVSSTLSSARFLRHLLRLPVTFFAQR
                     SPADLVQRLQSNDQVAETLARDLAAAGVDAVVVVLYALLLYTYDPQLTFVGIGVALLNI
                     VAMRVVVRLRATRTAKLRADTARLTNTAYTGLQLIETMKATGGEDGYFRKWAGQHATTL
                     EEQQRLGVPSAWLGVVAPTLATLNSALILWIGGMRAIEGHISVGLLVAFQALVTRFTAP
                     LTRLNGVAGRIQDFAADVARLKDVENFRTDPLYGRRGGADSTRRLSGHVELENIGFGYS
                     PLDKPLLSGFDLTVGPGQQVALVGGSGSGKSTVSRLIAGLYTPWEGVIRIDGQRLEDIP
                     RGALAASVSFVDQDVFLFEGSVRDNVALWDPSVPDDAVVEALRDAALYDVVMRRPGGIH
                     SRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAETEQIVMDNLRRRGCAC
                     VVIAHRLSTVRDSDEIVVLQHGQVVERGRHEELVARGGAYAALVRER"
     misc_feature    24835..24848
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 accgacggcc cggcgccgcg cggggcgacg ctcgccgtct ggcccgaccg ggtgcgcggc
       61 acgctgggcg ccgaggggct ggacgcggcc gtgaccgccg acgcgcgcgg tgagctggcc
      121 ctcggtgtca cggagctgcg gcactacggg ccgcacggcc agcggcgcga ggacgcggtg
      181 tcggtgttcc tgcactcctt cgcgccgccg ccgcggatgc tggtgttcgg cgcgatcgac
      241 tacgcggcgg ccgtcgcgcg gatcggtgac ttcctcggct accgggtcac cgtgtgcgac
      301 gcccgcccgg tcttcgccac gccgaagcgg ttcccgccgg gggtggaggt ggtcgtggag
      361 tggccgcacc gctatctgcg ggccacgggc accgacgcgc gcacggtggt ctgcgtcctc
      421 acccatgatc cgaagttcga cgtgccgctg ctcgcggagg cgctgcgccg gccggccgcg
      481 tacatcgggg cgatgggcag ccgccgtacg cacgaggagc gcaccaggcg gctggtcgcg
      541 gacgggctga cggccgcgga gctgggccgg ctgcgctcgc cggtggggct ggacctgggc
      601 gcccggacgc ccgaggaggt cgcggtgtcg gtcgccgcgg agatcgtcgc cctgcgctgg
      661 ggcggctcgg gcgccccgct gacggcgacg gccggggcga tccatccggg gcccgacggg
      721 cgtgcgaaat cggaggtgtg aagcgggcgc ggtggggtag tcgccgctca acggatgagg
      781 catgcatgca ctcagcaccc cttcgacctg gggaaggagg tccgtgacag cgcgcactcg
      841 cagcgcccgg gccgcttcgc cgagcgatga agcggcccgg cctttgcgct gtctccctcc
      901 tctggttcag cgcggcggca gccggtgcag ttccacgtcg gtgagccggc cgtcggcgac
      961 cgtggccgtc atgtaggtgc agtacggctg gcggcgccgg tccgtcggag agccggggtt
     1021 cagcagccgc aggccgccgg gtgcggtggt gtcccacggg atgtggctgt gcccgaagac
     1081 cagcacgtcc aggtcgggga agcgggcggc gcagcgggcc tcgcgcccct gggcggggcc
     1141 ggtctcgtgc acggcgccga agcgcaggcc gcccaggtcg gcgtacgcca cctcggggag
     1201 ccgggcgcgc agctccgggc cgtcgttgtt gccgtacacc ccgatgagcc gtcggctgtg
     1261 ctcctcgaac aggtcgaggg tggcggtgtc gacccagtcc cccgcgtgga agacgacgtc
     1321 ggcgcgcggc agttccgcca gcagcggggc ggggagttgc cgggcgcgct tggggaggtg
     1381 ggtgtcggtg gtcagaagca ggcgcacagg cccagcgtag gtcgcgcggt ggcgggctca
     1441 gccgaggcgt gccttcagcg gctcccacca gtcgcggtgc tcccggtacc aggcgacggt
     1501 ctcggcgagg ccggaggcga ggtcccggcg cggccggtag cccagctcgc ggcgggcctt
     1561 gctccagtcg acggagtacc gcaggtcgtg ggccttgcgg tcggtgacgt gctccaccat
     1621 gtcccagccg cagccgagcg cgtcgagcag cagcgaggtc agttcccggt tgctcagctc
     1681 ggtgccgccg ccgaggttgt agatctcgcc ggggcggccc tgggtgcgga ccagctcgac
     1741 gccgtggcag tggtcgtcga cgtgcagcca gtcgcggacg ttgcggccgt cgccgtagag
     1801 cggcacgggg cggccctcca ggaggtgggt gacgaacagc ggcacgacct tctcggggaa
     1861 ctggcgcggc ccgtagttgt tggagcagcg ggtgacgcgc acgtccaggc cgtgggtgcg
     1921 gtggcaggcc agcgccagca ggtcggagga ggccttggag gcggcgtacg gagaggtggg
     1981 ccgcaggggc gcctcctcgg tgcacgaacc ggagggtacg gagccgtaga cctcgtcggt
     2041 ggagacgtgc acgaagggtc ccgtgccgtg ccgcagcgcc gcgtccagca gggtctgggt
     2101 gcccagcacg ttggtgcgga cgaagtcgcc ggcgccctcg atggagcggt cgacgtggga
     2161 ctcggcggcg aagtgcacga cctggtccgc ctcggccatc agccggtcca ccaggccggc
     2221 gtcgcagatg tcgccccgga cgaaccgcag ccgcgggtgg tcctgcggga ggttgtccgg
     2281 ggtgcccgcg taggtgagct tgtccagcac cgtgatgtgc gggggctcgg ggcgggcgag
     2341 gagggtgcgg acgtaggccg agccgatgaa tccggcggct ccggtgacga gcaggttcat
     2401 gatgatcaga gcctacgtcg gcacccccgc cggacggccg aggcggtggg tcagtcctcg
     2461 ccccgcacga tgtgggcgtc accgccgctc tggagcgcgg gcggcccgcc gggctcctcc
     2521 accgcgggca tccaggtgcg cagcgcgtgc tcgcggcgca gcctgcgggc cctggcccag
     2581 cctgtctcgg gccggcgtat cggggacttc tccttggcct gcggggtcac ggcggatcat
     2641 cttccttctt gcatcgtgct tgtccgccga gtccccgcgg ccttccggcc caaaccgggc
     2701 ccggcgggtc tcaggcgccc ccggagccac cgctgccgaa ggagccgctg gagccttcgc
     2761 tccaccggcc gcgctcctgg tccccgctgg gtgcgccgcc ggtggggcgc agttcgtgcg
     2821 gggtgagccg ttcgccgtcg gtgcggggca tctcgtgcgg ggcgcgcatc tcatgactct
     2881 cgcggaccgg gccggagtcg ggcaggcgcg gctgctcctc gggccggggc gggcggtgtt
     2941 cacgccgccg tacgccgatg ccgagccgga cggcccagat cagaccggcg gtgatgagga
     3001 ctccggcgac gaggacggcg acgacgccga acgccgtgcc ggcggaagcg gcgaggtaca
     3061 gggtgctgtt catggagtgc gagtacccgg gcggcggccg cggatacgcc gtgggacgca
     3121 cccgggccgc ggcgccctgc gtggcgcggg caccggccgg gcccgcggcg gtagcgtcgc
     3181 cgcggtccgg ggaggaggac gatgacacaa ctctcggcac gcggcacgga agaaccgggg
     3241 cacaccggcg gccggcgctc ggcggcagcg gcgctgctgg aatggacgtc caccaccgat
     3301 cacaaggtga tcggccggct gtacatggtg acgtccttct gcttcttcct cctggccggt
     3361 ctgctggccc tcgccatgcg ggccgaactc gcccggccgg ggctgcagtt gctgaacagg
     3421 gacggctaca accagttcgt caccgtgcac ggcaccatca tgatgctgct gttcgcgacg
     3481 ccgatgttcg ccgggttcgc caacgccgtg atgccgctgc agatcggcgc tcccgacgtg
     3541 gcgttccccc ggctcaacgc cttgtcgtac tggatgtacc tgttcggcgg gctgatcgtg
     3601 gtgtcgggtt tcctggtgcc gggcggggcg gcgtcgttcg gctggttcgc ctacgcgccg
     3661 ctgaacagcg cgtaccacac gccgggcgcg ggcgccgacc tgtgggcgat ggggctggtg
     3721 gtgagcgggg tgtcgacgac gctgaccgcg gtcaacttca tcgcgaccat catgtgtctg
     3781 cgggcccccg gcatgaccat gttccggatg ccgctgttca cctggaacgt gctgttcacc
     3841 tcgatcctgg tgctgcccgc gttcccggtg ctgacggcgg cgctgctggc gctggaggcg
     3901 gaccggaagt tcggcgcgca cgtgttcgac gcggcgaacg gcggggcgct gctgtggcag
     3961 cacctgttct ggttcttcgg gcatccggag gtgtacatcg tggcgctgcc gttcttcggg
     4021 atcgtctcgg agatcatccc ggtgttctcc cgcaagccgc tgtgggggta tctgccgctg
     4081 atcggcgcga cgatcacgat caccatgctg tcggcggtgg tgtgggcgca ccacatgttc
     4141 gccacgggtg cggtgctgct gccgttcttc tcgctgatgt cgttcctgat cgccgtgccg
     4201 acgggcatca agttcttcgc gtgggtcggc acgatgaccc gggggtcgct gtcgttcgag
     4261 acgccgatgc tgtggtcgct ggggttcatg gtgtcgttcc tgctgggcgg gttgagcggg
     4321 gtgctgatcg cgtcgccgcc gctggacttc cacctcaccg actcgtactt catcgtcgcc
     4381 catctgcact acgtgctgtt cgggacggtg gtgttcgcga tgttcgccgg gttctacttc
     4441 tggtggccga agttcaccgg caagcacctc gacgaatggc tcggcaaact gcacttctgg
     4501 ctgctgttcc cggggttcca gctgacgttc ctggtgcagc actggctggg cgaggcgggc
     4561 atgccgcgcc ggtacgcgga ctatctgccc gccgacgggt tcacgctgct caacaccctc
     4621 tcgacggcgg gcgcgtttct gctgggggtg tccacgctgc cgttcctgta caacgtgtgg
     4681 cgaacgtcgc ggcggccgcg cacggtggac gtggacgatc cgtgggggtg gggccgttcg
     4741 ctggagtggg cgacgtcgtg cccgccgccg cggcacaact tcctggcgct gccgcgggtg
     4801 cgctcggagt cgccggcgtt cgatctgcac catccgtggc cggcgcgccg ggcgcgggag
     4861 gcggggcagc ggtgaaggcg gagtcgctgc tgttcggggg tgtggcgctg ttcttcgcgg
     4921 ggatcgccgc gctctacggc ggctggtcgg ccgagcccgc ggggacggcg gtgctggtgg
     4981 tggcgttcct gatggcggcg gtggtgtcgt tcttcagcgc ggtgcagtac cggcgccggg
     5041 gcgtgcgccc gcaggaccgg ggggacgccg aggtcgccga ggcggcgggg ccggtggagt
     5101 tcttcccgcc ggagagccgc tggccggtgg tgacggcggc cgggttcgcg ctcgccgcga
     5161 ccggcgtcgt cttcgggctg tggctgttcc tcatcggtgc cgcggtgctg gcccggggtg
     5221 ttctggggct ggtgttccag tacgccgacc gggactcggg ccggccggag tgagcggcgg
     5281 gcggggcgcg ccggggcgga cgtcggtgac cgggcgccgg ctctcctcgt agccgccctc
     5341 gacggtctgg cgtacctcgc cggtctccac gccgtcgcgc agccgctcct gctcggtgtc
     5401 gagaagggcg tggcacagtc cccgggtcag caggaacgcc aggaccggcg ccaccaccag
     5461 ggcgatgcgc agggtccagg tcatggcgtc gacggagatg cggaaggtgg cggcgacgac
     5521 gtcgttggcg ccggccagca gcaggacgcc gtagaaggtg atcccggcga cgccgagggc
     5581 cgtgcggacg ggtcgttcgc ggggccggtc gcacaggtgg tgctcgcgcc cgccctcgcc
     5641 cgtcaggcgc tgctcggcga aggggtagcc gtacaggacg aggaagagca ggccgggcag
     5701 gacgaccgcg ggcagcagga cgttccacat gagcgtgtgc ccggcgaggt tcgtctccca
     5761 gggcggtacg aggcgcagtg cgccctccag gaagccgacg tagaagtcgg gctgggagcc
     5821 ggtggaggcc tggtcggggc ggtaggggcc gtacacccag accgggttga cctgggcgag
     5881 gccgccgagc gcggccagca cgccgaagac ggtgcagaag aggccggccg aagtggccgc
     5941 gaactggggg aacatgggct tgccgacggc gttgcggacg gtgcggccgg ggccgcgcca
     6001 ctgggtgtgc ttgaggtgga agaccaggat caggtgcgcg gtcaccaggg cgaggatcgc
     6061 gccgggcagc agcaggatgt gcacgccgta caggcgggag atgaagtcca ggccggggaa
     6121 ctggccgccg aagacgaaga aggcgacgta ggtgccgacg accggcaggg acagcatgat
     6181 gccctgggcg atgcgcaggc cggtgccgga gagcaggtcg tcggggaggg agtagccggc
     6241 gaagccctcg gcgagggcga gcgcgaagag ggtcacgccg atgacccagt tgagttcgcg
     6301 ggggcggcgg aaggcgccgg tgaagaagac gcgcagcagg tgggtgccga tggcggcggc
     6361 gaagaccagc gccgcccagt ggtgcgcctg ccgcagcagc agtccgccgc gcacgtcgaa
     6421 gctgaggcgc agggtggact cgtaggccgc ggacatgcgg atgccgcgca gcgggacgta
     6481 gcggccggcg tagacgacct cgcgcatctc cgggtcgaag aagaacgtca gccacacccc
     6541 ggtgagcagc agcacgacca ggctgtacag ggcgatctcg ccgagcagga aggaccagtg
     6601 gtcggggaac gccttgcgca gcagcgcgcc gccctcggtg accgggagcc gtgcgtcggt
     6661 ggcgtcggcg agccgctcgc ctctccgcgg ccgcgccgcc gcgccggacg ccgcctccgg
     6721 aggtcgctct cgtgccacgc ccgtccacct ccctgtgccg gcccgccggt gcaccgctgt
     6781 gcagtgccct tcccccgcgc ggggcccggc gaccgggccg gcgcggggga aacacccgcg
     6841 ggtgcccgca cagtgcaccc gttcgggtgc ggcgggcgct tcgtcaggtg ttgggccggg
     6901 cgacgctgat gtcgccgagg gcggagccgg ggtcgcgttc catggcggcg tcgccgaggg
     6961 agacgatgcc gacggggtgg ccgtggtcga cgacggggat acggcggacg gagtgctcgc
     7021 gcatcagccg gatcgccacg tccagctcgt cgtccgggcc gacggtgacc aggtcgtcgc
     7081 tgcacgcgcc ggcgacggtg gtctgctcgg ggtcgcctcc ctcggcgagc gcgcgcacca
     7141 ccaggtcacg gtcggtgacc aggccgcgca ggtcgtcgcc gtcggtcacc aggaccgcgc
     7201 cgaggtcctc gtcgcgcatg atccgcgcca cctgggtcac cgaggcctgc ggctccacgg
     7261 tgacggggtc ggcggtcatg atgtcgcgta cgtgctgcgt catggcgcat ctcctctcgt
     7321 cggtctgtgc ggacccgggt acccgccccg cggcggacgg tcaccccggt cagcggccga
     7381 gcgcgagttc gctccacacc tgcttgccgc cgctgacggg caccgtgccc cagctgtccg
     7441 acagggcctc gacgaggagg atgccgcggc ccccggtggc ctcccagccg atgctggtgg
     7501 gcttgacggg gctgcgcggg gaggcgtcgg cgaccgcgac gcgcagccgg tggttgacga
     7561 gggtgaggtc gaggcggacg cggccgtcgg tgtgcacgag cgcgttggtg accagctcgg
     7621 acaccaccag cagcacggcg tcccggtccc gctcgggcac gttccaggag cgcagggtgc
     7681 gccgggtgaa gcgacgggcc tgcccgaccg cctgcggcac ccgccacacc gtccagctct
     7741 cgcgcagcgg gcgcgaggcc atgccgtcgt agcgcatcag cagcagggcg atgtcgtcgc
     7801 tgcggcgggc gccgccgagg agggcgtcgg cgaccggccc gaggtcggcg gggtcggcgg
     7861 cgccgagttc cccggcgaag cgggcgaggc cctggtcgat gtcggcgtcg gcggactcca
     7921 ccagcccgtc ggtggtgagg gcgaccacgg tgccggggcg cagggcgagc gggccgagcg
     7981 ggaactcggc ctgccgcagc acgcccagcg gcggcccgcc gtcggtctcg acgatctccg
     8041 tacggccgtc cgggtgacgc agcaccggcg gcaggtggcc ggcgcgcacg gaccaggcgg
     8101 agccggactc catgtccacc tcgacgtagc agcaggtggc gaagaggtcg gtctccaggt
     8161 cggcgaggag ccggttggcg tgcgcgacga ccacgtcggg cgggtggccc tcggcggcgt
     8221 aggcgcgcag cgcggtgcgc atctggccca tgagggtggc ggcggcggtg ctgtggccct
     8281 ggacatcgcc gatgacgagg gcgacgcggt tgtcgggcag cgggatcacg tcgtaccagt
     8341 cgccgccgac ctccagtccg gccgtggcgg gcaggtagcg ggcgacggcg accgcgccgg
     8401 gcagctgcgg caggcggcgc gggaggagct ggcgctggag catgccgacc agctcgtgct
     8461 cggcgtcgaa ggcgtgggcg cgcatcaggg cctgtccggc gaggccggcg gaggcggtga
     8521 gcagggcgcg ctcgtcgggg ccgaagtcgt gcggggtgtc ccagccgatc aggcaggcgc
     8581 ccgccatccg gccggccgcg ggcagcggca gcacggcgag gccgccgggg ccgacgtcgg
     8641 cgagggcggg ctccagggcg gtcccggcgg gccagatgcg ggcgcggccc tcgcgcagcg
     8701 ccgcggcgag ggtgggcatg gtgcgcacgg gcgcgtcggg ccactcggtg cgccactccc
     8761 gccgccacag ctcgggccag gcctcggggt ccggcgggtc caggacggtg acgacgaggc
     8821 ggtcgccctc cagctcggcg agggcgatgc ggtcggcgcg cagcgggcgg cgcagtgcgg
     8881 agacgacggc ctggctgacg tcgcggacgg tgccggcggt ggacagggcg gcggccagcc
     8941 gctgcacgcg ggcgacgtcg gtgacgtcgg agcgcagggt ggaggcgtcg gcgacggtgc
     9001 cgacgaggcg ggcggggcgg ccctcgccgc cgggcaccag ccggccgtgc agccgcagcc
     9061 agcggggcgg gccggccggc tggagcaccc ggaactccag ctcgcggtcg cccagggaca
     9121 tgtggtcggc ctcgacgacc gacatcagcg acggcaggtc ctcggggacg gtgaggccga
     9181 gcagcgtctc caccttgccg tcgaaccgct cccggctcag gccgaacagc tggaggatgt
     9241 cgtcgccgac ctcgatgcgt ccgctgtcca tggcgaggct gaaggcgttg gtgcgcagct
     9301 ccccgcgcgc ggcgggctcg tcgggggccg gggcggcgac ggcgtcggcg aggcgttcca
     9361 gactggcgcg cgcctccgcg tcgaagccgc cggggcgctc gctcaccgcg accaggcagc
     9421 cgccccgcac gggcagcgcg gccagcgaga actccttcgc cggggtccgt cgggaggggg
     9481 cgcgggcggc cagctcgcgc gggcctagcc acaccgcgcg ggcctcgcgg tgggcgcggg
     9541 cggccgggga gtcgccgttc agcgcgtagg tcccgcgcag gccgtacagg gtgcggggca
     9601 gtccggccgc gtcgaccagg cacagcagtt cggcgtcgtc gccgggggcg tacagggcgg
     9661 ccaccccggc gccggcgaag acgagcgcgc actccaggac accatgcacc cgttcgggtg
     9721 agtcgggatc ggccatgagc gtctggagag cggcttcgac gcgcggcgtt ccggttctgc
     9781 gccccgctgc tccctcactg accacctccg tattacagcg ctaatgggac gcccgcgcag
     9841 cccctgcggc cgttcggcgc aggtccggcg gggtgggtga tcgaaaggaa ccgaacaaga
     9901 gttgacgcgt gcgttccgca cggcgatgtg gtgacagccg tgactgtcgg cgccccgccc
     9961 tccgctggaa aggtcgtgcc cggaccacgg aggggaatcc atggacaagc ggtacgaggt
    10021 gtacgcgctc gccgaccggc acttctacga cacgccggac cgcacggccg gggccgccga
    10081 ggcggcggcg ccgctgctgg aggcggcgcg ccgggcggtg cccgagggct gggaggcggc
    10141 gcgcaccggg gactggctga cgctgacccc gctcggcgcg gacgggcgcc cgcagcccgg
    10201 cccggcgcag ggctggaagg tgcactcctc ggccaccccg gcgaacgccg agcggatcgc
    10261 ggcgatcgtg tgggactact gcgtgccgcg ccgcatcccg ttcaagttcg tgccggccgc
    10321 gcacctggtg cacctgcgca acgccaagta cgcgacgcgg gacaccagcg gcaagttcgt
    10381 caccctctac ccggacggcg aggagcagct gcacaccgtg ctgcgcgagc tgggcgagct
    10441 gctggcgggc ttcgaggggc cgtacatcct caccgacctg cgctggggcg acggcccgct
    10501 gcacgtgcgc tacggggcgt tcgcccgcgc ctacgtcgtc gacgagcgcg gcgcgctggt
    10561 gccggcggtc cgcgacggcg agggccggct ggtcccggac cggcggacgc cgtccttcca
    10621 ggtgccggag tgggtgacgc tgccggagtt cctccagccg catctggcgg cccgcaacac
    10681 cacgaccgtg ggcgagctgc cgtaccgcat cgacaaagcg ctgcacttct ccaacggcgg
    10741 cggggtctac gcgggcaccg acacgcgcac cgggcggaag gtggtcctca aggagggccg
    10801 cccgcacgcc gggctcgcag cggacggggc cgacgcggtg acccgcctgg agcgcgagcg
    10861 gcaggcgctg gagcggctgt cgggcacggg tgtggtgccg gaggtgcggg actggttcac
    10921 cctcggcgac caccgcttcc tggtgaccga cttcgtcgag gggaagccgc tgaacgcgtt
    10981 cttcgccgag cggcaccccc tgctcacacc cgatccggac ccggccgagg tcgccgcgta
    11041 cacgcggtgg gcggtgcgca tccaccgggc ggtcgaacag gccgtggagc aggtgcacgc
    11101 acgcggcatc gtcttcaacg acctgcacgt gttcaacatc atggtcgccc ccgacgagga
    11161 gtcggtgttg ctgctggact tcgaggccgc cgcgcccgcc gaggagcggg gccggcaggt
    11221 cgtcgcccac cccggcttct tcgcgccgcc ggaccggcgg ggcaccgacg tggaccgcta
    11281 cgcgctggcc tgtctgcggc tcgcgctgtt cctgccggtg accacgctgt tcgtggtgga
    11341 ccgcgggaag gcggcgcacc tcgcggaggt gatcgccggg cagttcccgg acctgccgga
    11401 gggcttcctc gccgaggcgg tcgccgagat cacccgctcg gccggggacg agccgtccgg
    11461 catacggccg ggggccgcgc cgctcgtcga ccccgcggac tggccgtaca gccgtgactc
    11521 gatggtcaag gcgatcctcg cctcggccac cccggagcgc gacgaccggc tcttccccgg
    11581 cgacatcgcc cagttctccg acggcggcgg cctcgggctc gcgcacggcg cggccggggt
    11641 gctgtacgcg ctcgccgcgg cggacggcat ccgctacgag gagggcgagc gctggctgct
    11701 ggcgcacacc gacccggccc cgccgggcac cccgctcggc ctgtacgacg gtctcgcggg
    11761 cgtcgcccac gtcctggacc tgctcggcca ccggcagcgg gccctcgacc tggtcgaggg
    11821 catcctgacg gagcggtggc agaacctgcc ctcggacctg cacggcgggc tcgccgggct
    11881 cggcctcgtc ctcgcccacc tcgcggacac gaccggcgag agcgcgctcg ggcggcgggc
    11941 cgacgaggcc gcgcggatcc tgctggggcg cctcgcggag ccggccgcgc ccaagcgccg
    12001 ggccgggctg ctgcgcggcg cgagcgggcc ggcgctgttc ctgctgcggc agtacgaacg
    12061 caacggcgac cggacgctgc tggacggcgc ggccgtcgcc ctgcgccggg acctggagcg
    12121 ctgcgtggtc cggccgggcg gctcgctgga ggtcgacgag ggctggcgga ccctgccgta
    12181 cctgggcgac ggcagcgccg gcgtcggaat ggtgctggac gacttcctcg ccctgtccgg
    12241 cgaccgggac ggaggctggg ccgaggcccg cgccggcatc ctgaccgccg cctccgcccg
    12301 cttctacgcg cagcccgggc tcttccaggg ccgcgccggg ctgatcctgc acctgcaccg
    12361 caccggggac ccggacggcc ggctgtccgg gcagatcgcc ggtctcggct ggtacgccat
    12421 ggcctaccag ggccaactcg ccttccccgg gcaccagatg atgcgtcttt ccatggacct
    12481 cgccaccgga acggccggct gcctgctggc gctcaccgcg gccctcgacg gcccggacgc
    12541 cgcgcacctg ccgttcctgc cgcccccgag gcggccctca tgacgcggca ccgcggatcc
    12601 gcggcgtcgt gacacaaccc gtccccacgg ggacaccccg tccccaccag aggaaggaac
    12661 acgaaatggc actgctcgac ctgcagacca tggagtccga cgagcacacc ggcggcggcg
    12721 gcgccagcac ggtcagcctg ctgtcgtgca tcagcgcggc cagcgttctg ctctgtctct
    12781 gacggacacc gcgcgaacga ggccccggac ggccgcctcc cctcacgggg cggggccgtc
    12841 cggggccctc accctttctc cgcaccctcc gggagtccac ggcatgcgac cacggtggca
    12901 ggacgatccg ctcacccgtg agagccgggc gctgctgcgc tcggcgggac ggcacagcgc
    12961 cgcccggtgc gccgcgctgt gtctggtgac ggccaccgcg accggcgccg agctgctgct
    13021 gcccgcggcg ctgggccggg ccctggacct gctgctcgcg caggcgccgg cgacccgctg
    13081 ggtgctgtgc tgcgcggcgc tcgtcctgct cgtcgccgcg ctcggtacgg ccgagaccgt
    13141 gctgcacggc accgtcgacg cccgcgccac cgcatggctg cgccgccgca cgctcgccca
    13201 ggtgctggca gcgggacccc gcaccgggga ccgcttcggc tccggcgacc tggtcgcgcg
    13261 gctcgtcggc aacgccgccc aggccggcgc ggcaccggcc gcccgggccg cgctgctggc
    13321 cgcgctcgcg ggcccggtcg ggggcgtcgt ggcgctggcg ctgatcgatc cctggctggc
    13381 ggtggtgttc ctggccgggg cgccgctgct ggccctgctg ctgcgggccc tggcccggga
    13441 cgtctccgcc tgcgtggccg actaccagcg ggtgcagggc cggatcgccg gggcgctcgc
    13501 ggaggcggtc gcgggccggc gcaccctgcg cgcggcgggc cttgaggcga aggagaccgc
    13561 ccggattctg cgtccgctgc ccgaactgtc cagggccggg cgggagatgt ggcgggtgca
    13621 ggggcgggcg gccgcgcagg cggtcgccgt ggcgcccctg ctccagctcg gcgtgatcgc
    13681 cgtggcgggg ctgctgctgg cccggcaccg gctgtccgcc ggagacgtcc tcgccgcctc
    13741 ccggtacgcc gtcctcgcca ccggcgtggg cgtgctcgtc ggacagctct ccggcctggc
    13801 ccgctcccgg acggcggccc agcggctcgg cgagctgcac accgtgccgg ccccggacca
    13861 cggcgagcgg cggctgccgg ccggcgggcc ggggcggctg gagttccgcc gggtgacggc
    13921 actgcgcggc gaccgtaccg tcctcaccgg cgtcgacctc gtcgtgccgg gcggcaccac
    13981 cctcgccgtc gtcggccgct cgggcaccgg caagtcgctg ctggcggcgc tcgccgcgcg
    14041 gctcgccgac ccggacgacg gggagatcct gctggacggc gtgccgctgc ccgagctgag
    14101 ccggcgggag ctgcgcgccg ccgtcgcctg cgccttcgac cggccggtgc tgctggggga
    14161 caccgtcggg gacgcgatcg ggctcggcct gcccggcccc tcccccgccc tggtccggga
    14221 ggcggcccgc acggcccacg ccgacgactt cgtccgccgc ctgccggacg gctacgccac
    14281 cgtctgcgcc gacgccccgc gctccggcgg cgagtcgcaa cgcctgggac tggcgcgggc
    14341 cttcgcccgg cgggcgcggc tgctcgtgct ggacgacgcc ctctccagcc tcgacaccgt
    14401 caccgaacac cgcatcaccc aggcgctgct ggcccccggc gcgcgcggca cccgtctcgt
    14461 cgtcgcccac cgcgccgcca cggccgcccg cgccgacgcg gtggtctggc tggacgacgg
    14521 ccgggtgcgt gcggtgggcc ggcacgccgc gctgtggcgg gaggccgggt accgggcggt
    14581 gttcggcgtg ccgacgggag aggagagcga cacgtgaagc gggaccgcgc gaggtccgga
    14641 ccctaccggc gcggcctgac cttcctgcgc cggcggtggc gggtgctgct gcggctgggc
    14701 ggctggtcgg tgctggagat gggccagacc ttcctgctcg ggtacgccct cgcgcgcgcc
    14761 ctcgacgagg gcttcctcgc cgggcggccc ggcacgggcc tgggctggct ggccgtcgcg
    14821 ggcgcgggcg tcgtcgtcgg cgcgtacggc accggacggg tgtacggcgc cgtggccgcg
    14881 ctggtcgagc cgctgcggga ccggctggtg gagcgggtcg tggcgcgcgg ggtgcgggag
    14941 gccgacgacg gcgcgctgtc ggggctgacc cagcaggtgg agatcgcccg ggacaccttc
    15001 gccgggctgg tcatggtgtc ccgctcgttc gtgttcaccg ccgcgggcgc gctcgtcggc
    15061 ctgttctcgc tcgccccgcc cctgctgctg gtcgtcctac cgccgctggc ggtcggcgtg
    15121 gccctgttcg cggtgacgct gcgcccgctg gcgcggcgtc aggaggcgta cctcgtcgcc
    15181 gacgaggcgc tggccgcacg gctgggcgcg gtctgccccg ggctgcggga catcacggcg
    15241 accggggcgg aggacgtgat cggggcggac ctcgcggtgt acgtcgaggc ggaggagcga
    15301 gcggcgcgcg cgctggcccg ctggtcggtg gtccgggtgg cgagcctcgc cgtcggcggc
    15361 cagttcccgg cggtgctgct gctggccacc gcgccctggc tgctcgccca cggcgtcacc
    15421 gccggcgcgc tggtcggcgc gctcgcctac gtcacccagt cgctgctccc cgccctgcgc
    15481 aacctcgtcc acgggctcgg cacggggggt tcccggctgg cggtggtgct gcggaggctg
    15541 acgggggcgg agggacagcc gggcgaggcg gaagaggcgg acgggcaggc cggtaaggga
    15601 acgcccgcac cggaccggcc ggcctcgcgg acggtcacct caccgggccg gccggcctcg
    15661 cggacggtcc ccgcgccccc ctcccctccc ccgcccgccc tccgcctctc gggcgtcacc
    15721 ttcgcccacg gcccccacgc cgagccggtc ctccagggac tcgacctcga cctgccggac
    15781 ggcgggcacc tcgccgtcgt cgggcccagc gggaccggca agtcgacgct caccctgctc
    15841 gccgccggtc tgctgcggcc cgggagcggc acggtcacgg tgtacggcga cccggccggc
    15901 gcgcgggccg cggcggcgcg ccgggtgctc atcccgcagg aggcgtacgt gcacaccggc
    15961 accctcgccg agaacctctc cctgctgcgg cccggcccgg tgccccggcg cgaactgctc
    16021 gccgcggccg aggcggtggg actcaccccg ctgctggagc ggctgggcgg accggaggcg
    16081 gtcgtggacc cggcggcgct gtcggccggt gagcggcagc tgatcgcgct cacccgggcc
    16141 tatctgtcgt acgcgccgct cgccctgctg gacgaggcga cctgccacct cgacccggag
    16201 gcggaggagc gcgccgagcg ggcgttcgcg gcgcggccgg gcggcacgct gctcgtcgtc
    16261 gcccaccgga tcacctcggc ccgcagggca cagcgggtgc tggtcatgga cgggccgcgt
    16321 accgcgtacg gcggccacga ggagctgctg gaccgctcgc cgggctaccg cgagctggtc
    16381 ggccactggg acccggcgtc acagccagcc ctggccctgg gagatgcgga tggcgtcgat
    16441 gcggttgcgg gcgccggtct tgcgggtgat ggccgccatg tagttgcgca cggtcccgtg
    16501 ggacaggtgc agcgaccccg cgatctcggc gacggaggcg ccctcggcgg cgagtgagag
    16561 cacgctcagc tcccgccggg tcagcggcat ctcggcggcc ttgagaaagc cgaagccgag
    16621 ggagtcgtcg acgaaacgtt ccccctcggc caggcggcgg atgccgcgta ataaacggtc
    16681 cggcgagccc tccttgtcga cgaagccgac cgcgcccgcc tccatggcgt gtctgagcag
    16741 ccccggccgg ttcgcggtgg ccagcaccag cagccgcgcc cggtcccggc cgcgggcgcg
    16801 cagatcaccg agcggcggca gcccgtgggc gccggaccac tccaggtcgg cggcgcacac
    16861 atcgggccgc acggcggcga cacgggccgc cgcctcgtcc cagcaactgc cctccacccg
    16921 cagatctggc gctctgtgca gccagtcggt cagaacggat cgcaccaacg acgcgtcgtg
    16981 caccagaagt acccggatca ctgccgcccc ttcagctcgc ttcgccggtg ttcgtggtgc
    17041 ccggcatgca tggtgttcag cgcctgcccc attgttgacg cgtgtgaccg tccgggggcg
    17101 cgaagatccg gccatcaggg tgcgcggggg cgcacacgcg gcgcttgtgc accgcgccgc
    17161 gcttcgactg cgggggcatg gtccgggagc ctcggggtac agggcggcgt tccgggcgga
    17221 cacgccggtg gcccggtccg cccccgggga gtgtgggggc gggccgggcc acgtctgcgg
    17281 gtgcgtcagt gcgtctcggt cagtccggag ttgccctcct ccgcgccgcc ggcacccgcg
    17341 tgcccgccgg cgcccatgcc gtcgcccgtg tcgtcgcccg tgtcggagcc gtcacccgca
    17401 ccggcctggt caccggcacc agcgccggcg tctcctccgc cggcctgctc accgccgggc
    17461 tcctggccgg caccttggtc ctggccggcc ccttgctcct ggccggcacc ctgctcctga
    17521 ccggcgcctt gctcctgacc gcccccggcc tggccgccgc ccgcgccgag cgtcgcgccc
    17581 gtcgcctgga gggccgtggt caccggctgg aagaaggtct cgccgccgga ggtgcagtca
    17641 ccgctaccgc ctgaggtcag gccgacggcg aggccgtcct gggtgaagag ggacccgccg
    17701 ctgtcgccgg gctcggcgca cacgtcggtc tggatgaggc cggtgacggt tccttcgggg
    17761 tagttgacgg tggcgtcgag accgaggacc tggccgtcgt gcaggccggt ggtgctgccc
    17821 atccggaaga cctgctggcc gaccgtcgcg tcggcggcct gggcgatctg cacggtctgc
    17881 ccgccgccga cgttgacctc gctcggcgcc tgggtgttcg ggtcgtcgta cttgacgagc
    17941 gcgaagtcgc cgttgccggg gaagacggcc tggtcgacgg tggcgatggg ctgtccgttc
    18001 tgggagtcgg accactgctg ggccgcgacg ccgcagtgac ctgccgtcag gaaggcgggc
    18061 gagccgtcgg aggcggtgac gttgaagccg agggagcagc gcgcgccgcc gccgaagatg
    18121 gcgtcgccgc cggagacgaa ggtcttgaag gtgcccgcgg acttcttgag ggtggccatg
    18181 ccggagccga gaccgcgtac cgccgactcc agtctgttcc acttcgcgcc ggtgacggtg
    18241 gagtcggcgg tgacgaggat cttgtcggtg cgcgggtcga cggcccaggc ggtgccggga
    18301 atggtggcct tgcgcttcag ggtctgcgcg cccgccttca gttcggcgag gctgttgtcg
    18361 acctcgcgga cggccgcgcc cgccttcttg gcctggatga tgacgttgtt gtcgtcgccc
    18421 ggcaccacgt tgaccacgag ctgctgcttg ccggcgtcgt agtaggagcc ggcgaaggcg
    18481 tcgccgagca ggttcgacag ctgggcggcg aggtccgagg cgtccgtgga cttcagcgtc
    18541 ctcggggcgg cggaggcgtc ggaagcgccg tcctgggagg cgttggcgtt cggcagcagg
    18601 atcgccgccg cgccgagcgc cgccacaccg cccgccgcta tcgcggcctt gcgcttcggg
    18661 attcgcttgt gactcaacct tctcgacctc ctggggggac ggggtctgcg ctgccggtcg
    18721 gcagccttgt tcagcggcgc ctggatggct ggaggtacgc accggccggg cggggcgttc
    18781 aattccgttt cccggcgggt ggcttggggc gcccgatccg gccaggacgc gggcagggcg
    18841 ggcgcgggcc gggaacaatc cctcacatga cgatgaccac ggcggaagcc gacaagatcc
    18901 tcgccgacaa cttcgccccc tgggtgctgg acctcggcct gtcggtccag gcggtcggcg
    18961 acgaccgggc gctgctgcgg ctgccctggt cggaccggct ggcccgggag ggcggggcgc
    19021 tgtccgggca ggcgctgatg gcggcggccg acacggcgac ggtgatcgcg gtgtcggcgg
    19081 cgcgcggcgc ctacggcccg atgacgaccg ttcagcagtc caccaccttc cagcgggcgg
    19141 tgaccggctc ggacgtgctg gtgcaggcgg tggtgacgaa gctgggccgg cggacggcct
    19201 tcgccgacat cacgctcgtc gacgaggcgt cgggtgagct ggcggcccac gcgagcaccg
    19261 tctacgcgct gctgggctga cacgctgcgc aaccggccgg gaacggtcgg ttgcgcacac
    19321 ggagcggaat cctggcttca gggaatctgc acatcgctcg cccaacgggg tcaccggcgg
    19381 taacagatct gcacaactca cgggggcaca tcacgccttg tgtgcggagt gtccgtttct
    19441 ccgtgccccg ggcgacgggc gggcctgtgc cgaaggcgcg cggcatgtga agaagccgcc
    19501 gacaccgcgt gcgcacgcct gcacggatgg ccggtccggg acatcaagtt ccctggtgag
    19561 agccatggtt gattggaagc gcgcggcggc ggcgtgcttt gatccatcgc accgcggggc
    19621 cccgttcgcg gttccccgcg tcccccttgt gaagtttcca taggaaggga agttccatca
    19681 tgaactccac cccccaggtc cagaccgccg agatctccga cgccgagctc gacaacgtct
    19741 cgggtggcct gtccatcaac gccgtgaaca cggtcaccgg tgccgtgaac ggcgtcgccc
    19801 cggtcggcgg cctgctggac accgtcgtcg gcaccgtcga gggtgtcacc ggcctgaaca
    19861 cggcccccgt caccaacctg gtcgccggtc tctgaccgca ccttttcgtg acgcccggag
    19921 tcccggggcc ggcgcatggc cccgggactc cggtatgccc tacaactccc ctaggctgag
    19981 ggaagttcct tgcagttccg ccaacaggcc ctcgccaagc tccagtcgcc ggaggagctg
    20041 gacctcccgg tgcgtctggc ccgtcctcag ggctggctcg tgctggccgt gaccggggcc
    20101 gcgatggccg ccgcctcggt gtgggcggtg accggttcgg tgacctcgac ggtcagcgcg
    20161 cccgcgatcc tcacgcacgg agagggcagc tacatcctgc agagccccgc cgccggccag
    20221 gtgacggccg tcctggcgaa ggagggcgag cggctgcccg ccggcgcccc cgtgctgaag
    20281 gtccgtaccg ccgagggcga gaccgtggtg cgcacggtcg ccgcgggccg gatcaccgcg
    20341 ctcgccgcca ccatcgggca gatcatcgcc accggcgcca acgtcgcggc cgtcgagaag
    20401 gtcgcccacc cgggcgaccc gctgtacgcg acggtgtacg tcccggccga gaccgccgcc
    20461 tcgatccccg cgcacgccac cgtcgacctg accgtgcaga cggtgccggc cgagcggtac
    20521 ggcgtgctgc gcggccatgt gcagtcggtg gaccgcaccg cgcagtcggc gcggcagatc
    20581 gccgcgttcc tcggcgacag ccagctgggc gagcagttca ccgagcaggg ccgcccggtc
    20641 gccgtgacgg tgcgcctgga cacctccgcg gcgacgagga gcggctaccg ctggtcgtcc
    20701 gcgggcggcc cgccgtacgc cctgacctcc atgaccctgg ccacgggtgc gatccggctg
    20761 gccgaccagc gtcccgtcga ttggctgctg ccgtgaccac cgccgctccc gagacccggg
    20821 gccgccgccg cgcggccccg ccgaagcgtt ccgtgccgaa ggcgcgcggg aaggccgtgc
    20881 gcacgcagag cgtgctgcag atggaggccg tcgagtgcgg cgccgcctcg ctggccatgg
    20941 tgctcggcca ctacggccgc catgtcccgc tggaggagct gcgcatcgcc tgcggtgtct
    21001 cccgcgacgg ctcacgtgcc tccaatctgc tgaaggcggc gcggagttac ggcctcacgg
    21061 ccaagggcat gcagatggac ctggccgcgc tcgccgaggt cgcggcgccg gcgatcctgt
    21121 tctgggagtt caaccactac gtcgtctacg acggcatggg ccgccggttc ggccgccgcg
    21181 gcgtgttcgt caacgacccc gccaagggcc gcaggttcgt gccgctggag gacttcgacg
    21241 gcagcttcac cggtgtcgtg ctggtgatgg agccgggcga ggacttcgtc aggggcgggc
    21301 ggaagcccgg cgtgtggggg gcgatgccgg cccggctgcg cggcaccgcg gggacgctgc
    21361 cggcggcggt gctggcgagt ctgctgctgg tgctggtcgg ggcggccgtg cccgcgctga
    21421 gccgcaccta catcgacatg ttcctgatcg gcggtcagac ctcgctgctc ggggtgctgt
    21481 tcgcggcgat ggcggcgtgc gtggcgctca cggtcgcgct gacctggctg cagcaggcca
    21541 atctgcacca cggccgcatc gtctcctcca ccctgtccag cgcccgtttc ctgcggcatc
    21601 tgctgcggct gccggtgacg ttcttcgccc agcgcagccc ggccgacctg gtgcagcggc
    21661 tgcagtccaa cgaccaggtc gccgagaccc tggcccggga cctggcggcg gcgggcgtgg
    21721 acgcggtggt cgtcgtgctg tacgcgctcc tgctgtacac ctacgacccg cagctgacgt
    21781 tcgtcgggat cggggtggcg ctgctgaaca tcgtcgccat gcgggtcgtc gtacggctgc
    21841 gggcgacgcg gacggcgaag ctgcgcgcgg acaccgcccg gctcaccaac accgcgtaca
    21901 cgggtctgca gctgatcgag acgatgaagg cgaccggcgg tgaggacggc tacttccgca
    21961 agtgggccgg gcagcacgcc accacgctgg aggagcagca gcggctcggg gtgccgagtg
    22021 cctggctcgg ggtggtcgcg ccgaccctgg ccacgctgaa cagcgcgctg atcctgtgga
    22081 tcggcggcat gcgggcgatc gaggggcaca tctcggtcgg cctgctggtg gccttccagg
    22141 cgctggtgac ccggttcacc gcgccgctga cccggctcaa cggcgtcgcg ggccggatcc
    22201 aggacttcgc ggcggacgtg gcccggctga aggacgtgga gaacttccgc accgacccgc
    22261 tctacggccg tcgcggcggc gccgactcca cgcggaggct gagcggccac gtcgagctgg
    22321 agaacatcgg cttcggctac agcccgctgg acaagccgct gctgtccggc ttcgacctga
    22381 ccgtcgggcc gggtcagcag gtggcgctgg tcggcggttc gggcagcggc aagtcgacgg
    22441 tgtcccggct gatcgcgggc ctgtacacgc cgtgggaggg cgtgatccgc atcgacgggc
    22501 agcgtctgga ggacatcccg cgcggcgcgc tggccgcctc ggtgtccttc gtcgaccagg
    22561 acgtgttcct gttcgagggc agtgtgcgcg acaacgtggc gctgtgggac ccgtcggtgc
    22621 cggacgacgc ggtggtggag gcgctgcggg acgcggcgct gtacgacgtg gtgatgcgtc
    22681 ggccgggcgg catccacagc cgggtggagc aggacggccg caacttctcc ggcgggcagc
    22741 ggcagcggct ggagatcgcg cgggcgctgg tgcgccggcc gagcatcctc gtgctggacg
    22801 aggtgacgag cgcgctggac gcggagaccg agcagatcgt gatggacaac ctgcggcggc
    22861 gcggctgtgc ctgtgtggtg atcgcgcacc ggctgagcac ggtccgcgac agcgacgaga
    22921 tcgtggtgct ccagcacggg caggtcgtcg agcgcggccg gcacgaggag ctggtggcgc
    22981 gcggcggggc gtacgcggcg ctggtcaggg agcggtgaga tgacggtcgt ggacgaaggc
    23041 gacctggtcc tcggggcgct cgggcagtcg ggcacgccgt tcgactgcgc gggcctgacc
    23101 cggctcgacc tggaggggcc gcaggtgctg tggctggtgg tgcgcggggc gctggacctg
    23161 ttcgcggtgg acgccgccgc gcagggccac tggcaccacc tgggccggct ggaggcgggc
    23221 tcgctgctgc tggggccggt cgcgggcgcg cagcacacgc tggtcgcgcg gccggtgcgg
    23281 gactgcgtgg tgcaccgcat cgggctgcgt gagctgtacc agccggcgca gacccagacc
    23341 tgggcgtacg acgagtacgg caacccgcag tacgtgccgc cggtgacgag cccgctggaa
    23401 cacgccctcg cgctcggcgt cggccggagc ctgtcggtgc tgttccaggc gccgatggcg
    23461 agcgagggcg ccgccgagct gagcgacgac gacgtgttct ggatgcaggt gccgccgggc
    23521 agcgtccagt acggctcgct gtacggcgcg gaggcggcgg ccgatctgct gatggacccg
    23581 gcggtgtggc agggcctggt cgaccagcag taccggctgc tggcgacgct ggaccggtgg
    23641 atcgagcagc tggagcgcac ccacgagacc cgcacggccg agggcatccg ggccggtgag
    23701 gcggtgcgcg cgcaggccga ccggacgctg ctggcctcga tcggccgctc gtcggccaag
    23761 cgcgcgacgg ccgccgacac ggacgccacg tacgcggcgt gccggctcgt cgcgcgggcc
    23821 gcgggcatca cgctcgcgga gcccgcgcag gcgggggcgg acagcgaccg gctcgacccg
    23881 gtggagcgca tcgcgctggc ctcgcgggtg cggacccggg cggtacggct gaccggccgc
    23941 tggtggcggg agaacgcggg gccgctggtg ggccggcggg cgctgtccgg agcgccggtc
    24001 gcgctgctgt ggcggcgcgg cggatacgtc gccgtgcatc cgtcgaccgg ccgggagacg
    24061 ccggtcgaac aggccaacgc ggaggagttc gagccgcggg cggtgatgtt ctaccgtccg
    24121 ctgcccgacc gccggctcgg tccgctgggc ctgctgcggt tcaccctgcg gggcaccggc
    24181 ccggacctgg cgtggctgct ggtggccggg ctggtgacgg tggcgatcgg ggcgctggtg
    24241 ccgatcgcga cgggcaaggt gctcggcgag tacgtgccgg ccgcgcggtc cgggccgatc
    24301 gtgcaggtgt gcctggcggt gatggtcggc agtgtcgtgg cggcggcgtt catgctgctg
    24361 cagaacctga ccatcctgcg cctggagggc cgtatcgagg cgacgctcca gcccgccgtg
    24421 tgggaccggc tgctgcggct gccgacgacg ttcttcacgc ggcgttccac gggcgagctg
    24481 gccagcgcgg cgatgggcgt cagcgcgatg cgccggctgc tcgcgggcgt gggaccgacg
    24541 gtggcgcagg cggtgaccgt cggcgcgatg aacctggcat tgctgctgtg gtacagcgtg
    24601 ccgctggcga tggccgcgct ggggatgctc gtagtgatcg cgggggtgtt cctggggctc
    24661 gggctgtggc aggtgcgctg gcagcgccgc ctggtggtgc tcggcaacaa gctgaacaac
    24721 caggccttcc agacgctgcg gggcctgccg aagctgcggg tggcggcggc cgagaactac
    24781 gcctacgcgg cgtgggcggc gcagttcgcg cgcagccggg agctgcagca gcggctgggc
    24841 cggatcaaga acctgaacac cgtgctgggc gcggtgtacc tgccggtgtg cacgc
//
