LOCUS       NZ_BNBM01000032        10811 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence32, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000032
VERSION     NZ_BNBM01000032.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 47136)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 19201
            Orig. end                         :: 30012
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000032.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10811
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10811
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10811
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5811](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5811)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(9..341)
                     /locus_tag="IE325_RS45115"
                     /old_locus_tag="GCM10018780_91660"
     CDS             complement(9..341)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025895.5"
                     /locus_tag="IE325_RS45115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91660"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190076046.1"
                     /transl_table=11
                     /translation="MDRDKYTDLDIHVAKDTKAETYDAWLGPERIGTLVYQLTAGRVAM
                     ISIAVEPEYQHHGVSAELIASALDDVADSGAKVTIICPVVRSFIDEHPEYAGVVDPNRP
                     GIRTRR"
     misc_feature    complement(373..393)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.65"
                     /tool="antismash"
     misc_feature    complement(461..473)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.38"
                     /tool="antismash"
     misc_feature    485..500
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.74"
                     /tool="antismash"
     gene            complement(523..1360)
                     /locus_tag="IE325_RS45120"
                     /pseudo=""
     CDS             complement(523..1360)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139034.1"
                     /locus_tag="IE325_RS45120"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPHGPYPSDPSDARWELIKPLLTSWRDQRRARALDIGRPPERDL
                     RQITNAIMYVDRTGIPWRYLPHDFAPWATVYGYFAKWQQDGVFEQLTGLLRRLVREAEG
                     RDAEPSACVLDSQTIKTSANVPRRAEHRRRKADHRAQAPPRLRHPRPAADRASHRRQCL
                     RHRGRRDPAVPHRRRPPAHHEGLGGRPLPHHRHRPRRPPRHRRPPRPPAARYPRVHDHP
                     ETVDHRAQHRMAHAPPTARPRLRTPPAPLRSHDPPRQDRPHGPQTHRRSHPELARNL"
     gene            1618..>1734
                     /locus_tag="IE325_RS45125"
                     /pseudo=""
     CDS             1618..>1734
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558177.1"
                     /locus_tag="IE325_RS45125"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVERLVPDKLWELFQRVVPAAPVRPQGGGRRRYGGRQVL"
     misc_feature    complement(1636..1650)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 21.76"
                     /tool="antismash"
     gene            complement(1746..2348)
                     /gene="wrbA"
                     /locus_tag="IE325_RS45130"
                     /old_locus_tag="GCM10018780_91680"
     CDS             complement(1746..2348)
                     /EC_number="1.6.5.2"
                     /GO_function="GO:0003955 - NAD(P)H dehydrogenase (quinone)
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /gene="wrbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006137008.1"
                     /locus_tag="IE325_RS45130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91680"
                     /product="NAD(P)H:quinone oxidoreductase"
                     /protein_id="WP_190076047.1"
                     /transl_table=11
                     /translation="MAVRLAVIYYSATGNVHQLAEALAKGGEGREAEVRLLRVPELAPD
                     TAIDANPAWRTHVDTMKDSVREATLEDLEWASAYAFGTPTRYGNVSAQLKQFIDSTGAL
                     WQAGVFHNKPVTSFTSATNRHGGQESTLLSLNNVFYHWGCIIVPPGYTNPVLFGAGGNP
                     YGTSWPSGGGEGPDQATLDAANYQGRHLVEIAERLRG"
     misc_feature    complement(2383..2397)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            2759..3902
                     /locus_tag="IE325_RS45140"
                     /old_locus_tag="GCM10018780_91700"
                     /pseudo=""
     CDS             2759..3902
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611765.1"
                     /locus_tag="IE325_RS45140"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91700"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPRSYPPEFRRKVLDLVESGRKVAEVAQLLGISEQTIYVWRRQRL
                     IDTGQLPGTTTAENAELAAARRRIAELEAEVKIHRRAAELLGETTSPRGGSKPST"
     gene            4157..4612
                     /locus_tag="IE325_RS45145"
                     /old_locus_tag="GCM10018780_91710"
     CDS             4157..4612
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057779.1"
                     /locus_tag="IE325_RS45145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91710"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_190076050.1"
                     /transl_table=11
                     /translation="MPLEGEYEPSPEQWVRDQVELYESSGGSKGNTSPDIRLPVIILTT
                     RGAKSGKIRKTPLMRVAHEGMYAVVASQGGAPKHPVWYFNVKADPHVELQDGPVNQDMR
                     AREVTGAEKAQWWERAVAAYPPYAEYQRNTDREIPVFVLEPANSSAD"
     gene            complement(5001..5811)
                     /locus_tag="IE325_RS45150"
                     /old_locus_tag="GCM10018780_91720"
                     /pseudo=""
     CDS             complement(5001..5811)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669186.1"
                     /locus_tag="IE325_RS45150"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91720"
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /pseudo=""
                     /sec_met_domain="Linocin_M18 (E-value: 8.6e-31, bitscore:
                     98.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNLHRELAPLSAAAWSDLEEEIRRTFKRHAAARRIVDVPKPCGV
                     ELGGVTIGHLDRVDAPADGVIAHTRRFQPMVELRVPFTVDRRQVDDVARGQGRRLAAGQ
                     GRRPAACLRRGPGRLRRVCGRRHRRPARELLKLTRDAALRRPRLPGRDQPGGLCPATGR
                     CRRRLLSSPERGNVHGGQ"
     gene            complement(5792..6880)
                     /locus_tag="IE325_RS45155"
                     /old_locus_tag="GCM10018780_91730"
     CDS             complement(5792..6880)
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172773.1"
                     /locus_tag="IE325_RS45155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91730"
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_190076051.1"
                     /transl_table=11
                     /translation="MTDETSAPTPQPVLSPLTSAAIFLVATIDPGGEAVTRGVLSDLNS
                     LQRAAGFRAEPEGRLSCVTGIGSHAWSRLFAGPRPAELHPFRELNGPVHRAVSTPGDLL
                     FHIRASRLDLCFALATEIMTRLGTAVTVRDEVHGFQYFDKRDLLGFVDGTENPTGAAAS
                     NAVLIGDEDAEFAGGSYVIVQKYVHDLAGWNALPVEAQEKIIGRTKLSDIELDDNSQPS
                     DSHVALTTITDPDGTEREILRDNMPFGTVGRGEFGTYFIGYARTPTVTEAMLERMFLGT
                     ADASHDRILDFSTPVTGCLFHVPTADFLDDLPAPPGVESGKAATDQHAAATATPDSQPR
                     FPDTSLGIGSLKRSTPDGQSAP"
     gene            complement(7012..7482)
                     /gene="msrB"
                     /locus_tag="IE325_RS45160"
                     /old_locus_tag="GCM10018780_91740"
     CDS             complement(7012..7482)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000290139.1"
                     /locus_tag="IE325_RS45160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91740"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_190076052.1"
                     /transl_table=11
                     /translation="MSEYHKDAERIAQLTEQQYRVTQQDETEPAFANAFWDNKVPGIYV
                     DIVSGEPLFSSADKYDSRTGWPSFTKPLESGHVVERSDTSHGMVRVEVRSGKGDSHLGH
                     LFPDGPRDKGGLRYCINSASLRFIPVEELEREGYGQYLSMFNTPEGGAVETE"
     misc_feature    7785..7800
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.46"
                     /tool="antismash"
     gene            7819..8415
                     /locus_tag="IE325_RS45165"
                     /old_locus_tag="GCM10018780_91750"
     CDS             7819..8415
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016176.5"
                     /locus_tag="IE325_RS45165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91750"
                     /product="YceI family protein"
                     /protein_id="WP_190076053.1"
                     /transl_table=11
                     /translation="MTSGQGGRLIGPPIAADAAAYFIDPAYSNVSFSARNRMATSTRGA
                     FRRFAGTLFLDSERPERTALALYVTSSSIDTGQKDRDADLCSAALLDAEQYPLMSFWSS
                     SAEAVDTNLCRLAGSLRVKNMTMPLGVDCEYRGRTHGPQGDERVGFLGRSVLRRSEWGS
                     LWGPVVHAGEWIVGDEVELLFEVSAVKRAPIRWWP"
     gene            complement(8636..10003)
                     /locus_tag="IE325_RS45170"
                     /old_locus_tag="GCM10018780_91760"
     CDS             complement(8636..10003)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432594.1"
                     /locus_tag="IE325_RS45170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_91760"
                     /product="MFS transporter"
                     /protein_id="WP_190076054.1"
                     /transl_table=11
                     /translation="MSETTSSRSATVSGSKPIRLPGFIDERRLGGFQLRTVLLCALVML
                     LDGFDTQAINYMAPAITQDWDVSKGTMATIFSAALVGLMIGYLLLAPLSDKLGHKRLVM
                     AGVALFSLSTLVSVGAQSPDQLMIMRFITGIGLGAATPSTIALTAEYSPKRLRASLVLA
                     IYCGFSLGFVAANYAAGWLIPAYGWRSVFVAGAVLPLAMLPVLAWRLPESISYLLRRGQ
                     NAKAYAHLRRIDRMLPETGEAHIEAESADPGKRVKVTELLTGRQLLGTVLLWVVFAINL
                     AMFYGLQSWMPTILSERGYSAGTLATAASMTTIGGIVIAFVIGPAMDRLGAYGSLSTLY
                     FVGCGFLVLMGLVLGSPVWMVLAAIFLIGCTISGGQKSVIALAAALYPEEVRSTGVGWA
                     LGIGRVGGIVGPMIVGGMLAGGIGHEQLFMILVAPAALCGLIVLYLGHRAKRLELA"
ORIGIN
        1 cccagacgtc agcggcgtgt ccggatacct gggcggttag ggtcgacgac accggcatac
       61 tcgggatgct cgtcgatgaa tgatcggact accgggcaga tgatcgtcac ctttgctcca
      121 gaatcggcga catcatcgag cgcgctggca atcagctccg cggacacacc atgatgctgg
      181 tactccggtt ccactgcgat cgagatcatc gcgaccctgc cggccgtcaa ctggtagacc
      241 agggtcccga tgcgctccgg cccgagccac gcgtcgtatg tctccgcctt ggtgtccttc
      301 gccacatgga tgtcgaggtc tgtgtacttg tctctgtcca tgccatgaca gcgccgcaga
      361 gcaggtgatt cttactcgta agaatcacta aataggggtg gtgacggccc agggccgtgg
      421 tcaatcaagg tggccgctct agtcgacaga cctcaacggt gtgacagtga cacccacgtt
      481 cttactgagc gtttggtccg gtgtttcgtg tttggtcccg ggtcaggttc cgcgccagtt
      541 cggggtggct tcgccggtga gtctgtgggc catgaggtcg atcttggcga ggtggatcat
      601 ggcttcggag cggtgcgggt ggcgttcgta gtcgcgggcg agccgtcggt ggtgcatgag
      661 ccatccgatg ctgcgctcga tggtccaccg tctcgggatg atcgtgaacc cgcgggtacc
      721 gggcggccgg tggacggggt ggacgtcgat gccgaggcgg gcgccgtggt cgatggcggt
      781 ggtgcggtag cgggcgtcca cccaggcctt cgtgatgtgc gggtgggcgg cggcgatgcg
      841 ggacagcagg gtcacgccgg ccgcggtgtc ggagacactg gcggcggtga ctagcacggt
      901 cagcagcagg ccgagggtgt cgcagccgag gtggcgcttg cgcccgatga tccgctttcc
      961 ggcgtcggtg ctctgctcgg cggggcacgt tggcggaggt cttgatggtc tgggagtcca
     1021 gcacgcaggc cgacggctcg gcgtcacggc cctcggcttc gcggaccaga cgccgcagca
     1081 ggccggtgag ctgctcgaag acgccgtcct gctgccactt ggcgaagtac ccgtacaccg
     1141 tggcccacgg ggcgaagtcg tgcgggaggt agcgccaggg gatgccggtg cggtccacgt
     1201 acatgatggc gttcgtgatc tggcgcaggt cgcgttcggg tggtcggccg atgtccagcg
     1261 cacgggcgcg gcgctggtcc cgccaggacg tcaggagggg cttgatcagt tcccagcgcg
     1321 cgtccgacgg gtcgctggga taggggccgt gcggagtcat gtttgcgaag tagccgaccg
     1381 cgaccggccc cgccaccggt caaaaggcgg cgctcggggg cgtgttggga gcagacagga
     1441 gcagccggaa cgaaacaact cccaggcatc gccgacgcgt cgactgtccc atcaagcaca
     1501 gcggctctgg cactgcaggg ctctggaatc gacaccaact cgaccgagac aggaccaaac
     1561 gctcagttag atgtcgtctc aactggcttg atcactaggc tgaccgccgt ggtggccatg
     1621 gtggagcgtc tggtaccaga caagttgtgg gagttgttcc agcgggtagt tccggcggct
     1681 ccggtacgac cgcaaggcgg gggacgccgc cgttacgggg gccggcaggt gctctacgta
     1741 aacgcttagc cgcgcaaccg ctccgcgatc tccacaaggt gccgaccctg atagttggcc
     1801 gcgtccaggg ttgcctgatc gggcccttcg cctccgccgc tcggccagct cgtcccatag
     1861 ggattgccgc cggccccgaa cagcaccgga ttggtgtagc cggggggaac gatgatgcaa
     1921 ccccagtggt agaagacgtt gttgagggac agcagcgtcg actcctggcc accgtgacga
     1981 ttcgtcgccg aggtgaaact cgtgacgggc ttgttgtgga acacgccggc ctgccacagt
     2041 gctccggtcg agtcgatgaa ctgtttgagc tgggccgaca cgtttccata ccgggtcggt
     2101 gtgccgaacg cgtacgccga cgcccactcc aggtcctcca aggtcgcctc gcggaccgag
     2161 tccttcatgg tgtcaacgtg agttcgccag gccgggttgg cgtctatggc tgtgtcaggc
     2221 gccagctcgg gaacacgtag gaggcgaact tcagcttctc ggccttcccc acccttcgcg
     2281 agcgcttccg ccagctggtg gacattcccg gtggcgctgt agtagatgac cgcgaggcgc
     2341 acagccatga gcgaactcct tttctgcata gttcggttca caatcgacgg agatgtttcc
     2401 cgtcggcagc agggatcgtt ctcggttcgt tctggacggt gaagcgaccg gccctgtcac
     2461 cctccatgcc tggaacgggt tcgagggaag taccgtcgga tcgcgctccc ggacctggtt
     2521 ggttcgcctg acgaccggag ccggccgcca gtcaatgagt gagcgcccgg aaagaccaac
     2581 ttcttacctc tggccgtgcc gagccgcctc cgtctccgcc tcctgcaccc ccccacgaat
     2641 ccatccctat atgcccagac tgatatgtac cgactacggt gtggaccctg atgtgccccg
     2701 ggtctgatgg agtcaggttg ctggagaatt gaccgtccag cagcatccgg aggcagtcat
     2761 gccccgtagt tatcctcccg agttccgtcg caaggtcctg gacttggtcg agtccggccg
     2821 caaggtcgct gaagtcgccc aactcctggg aatcagcgag cagacgatct atgtgtggcg
     2881 ccgtcagcga ttgatcgaca ctggtcagct gcccggcacc acgaccgctg agaatgccga
     2941 actggccgcc gcgcgacggc ggatcgccga gctggaagcg gaggtgaaga tccaccgcag
     3001 agctgctgag ctcctcggcg agacaacctc cccaagaggc ggttcgaagc catcgacgtg
     3061 atggccggcg agggcctacc ggtccagctg gcctcccggg tcctgcacgt ggcagagtcc
     3121 ggctactacg cctggcgcag ccgaccgccc tcggcccgct cggtcagaca cgcgtggctg
     3181 accgaagcca tcacgagcat tcacaccgac tcgcgcggaa cgtatggatt ccgccgtatc
     3241 catgctgagc tggacctcgg gttaggcatt cacgtcagcc acggcacggt ggaactgctc
     3301 atgcaacgcg cccagatcca cgggctgccc ggcaaccggc ggccccggcc acggcacgag
     3361 accccgtcgg cgagcgacct ggtggagagg aacttccgcc gcaccgcgag agaccagctg
     3421 tgggtcaccg acatcactga acaccccacc cgggaaggca aggtctactg cgctgtcgtc
     3481 ctggacgtcc actcacgacg agtcgtcggc tggtccatcg acgcctcagc caccgccgct
     3541 ctggccacca atgcgctgag catggcgatc ggcaaccgcc gcccacggcc gggcgccacc
     3601 atcatccatt ccgatcacgg ggtgcagttc agctcctggg ccttcaccga gcgcgccagg
     3661 tccagcgggc tggtggcctc gatgggctcg atcggcgact gcgcggacaa cgcgctgatg
     3721 gagtccttct gggacgagta cagacagaac tcctcaaccg ccgacgctgg cgaacccgga
     3781 tggagctctc caccgcactg ttcgagtacc tcgagatctt ccacaaccgg caacgcaggc
     3841 actccgccct gggattgctc accccagtcc agtacgagct gcagcaaccg cctgtagcgt
     3901 gaaacccagc gacgcggctc catacaagtc ggggcacatc accccgctgt ctcagagccg
     3961 tgagtacagg accccgcacg cagcctgacg accacaccga atgtgtctgt cgaagcggaa
     4021 ccggcgcggt aagaagttcc ttctcccggg cgctcacttc tgaagaggtc tgaagagcca
     4081 acaagagagc agcgtgcagc cgccggtgtt accccggtac ctgggcatgc atggcaacga
     4141 tgaaggagac ggatccatgc ctctcgaagg tgagtacgag ccgagcccgg agcagtgggt
     4201 acgcgatcag gtggagctgt acgagagttc cggcgggtcg aaggggaaca cctcgcccga
     4261 catcaggctg ccggtcatca tcctgacgac ccggggtgcg aagagtggca agatccgcaa
     4321 gacaccgctg atgcgggtgg cgcacgaggg catgtacgcg gtggtcgcct cgcaaggcgg
     4381 tgcgccgaag catccggtct ggtacttcaa cgtcaaggcc gatccgcacg tcgagttgca
     4441 ggacggcccg gtcaatcagg acatgcgggc acgtgaggtc accggagccg agaaggccca
     4501 gtggtgggag cgggcggtcg ccgcttaccc gccgtacgcg gagtaccagc gcaacaccga
     4561 ccgggagatt ccggtattcg tactggagcc ggcgaactcc agcgcagact gacggtgctc
     4621 ggcccgctga tcatccccgg cccagtcctc attgtttctc accccgggcg ccgcaacgga
     4681 tcgctcgtgc gcaggtggct ggtgatgcta cggcaacccc acgtggggat gaggcgctgc
     4741 gggcatcctc gttgctcgag cggcagcagc gacacctgcg gtgcctcaac tccttctgcg
     4801 ggttggggcg ctggcgagag cgatcgcccg attcttcggt ccacgtcagg accaaggacc
     4861 gaccagtcct gaacattcga ccctcggtga gtacccactc tcggcgtgga acgggatcgt
     4921 catggcggga gcctctgctc cagaccgcag tggtccccgc cgatgcggac ctgcttccac
     4981 cgatcggcat ttactcccag tcaggcatcg gtcggctgcg acacgaaggc cgcaaccgct
     5041 tcgctggagt ggaccaggaa ggtgaaggtc tcctccaagt acagggggac gctggtcgca
     5101 tcgtgggaga ggtagccgat cgacacgtcc tggccaaggt gcatctcgaa gtcgccgccg
     5161 cgggtggaga gcgggaaggc gccgtcgatg gcgggcgccc agacaatgtc tccgtccagc
     5221 agcctggcga tgtgcttgat gatcgggtag ccgtggtctg aagtctcact gaccgccgtg
     5281 tacgtttccg cgctcagggc tagagagtag gcgccgtcga cacctgccag tcgcagggca
     5341 gagaccgcct ggctgatcgc gtccgggtag tcgcggacgt cggagggcag cgtcacgggt
     5401 gagtttgagg agctctcgcg caggccggcg atggcggcgg ccgcataccc ttcgaagacg
     5461 gcccggtcct cggcgaaggc aagccgccgg gcggcgtcct tggccggctg ccagtcggcg
     5521 tccttggcct cgagcgacgt cgtcgacctg gcggcggtcg acggtgaacg ggacacgcag
     5581 ctcgaccatg ggctggaagc ggcgcgtgtg ggcgatcacg ccatcggcgg gggcgtccac
     5641 cctgtcgagg tgccctatgg tcacaccccc caactcgact ccgcacggct tcgggacgtc
     5701 gacgatgcgt cgtgccgccg cgtgccgttt gaaggtgcgt cggatctctt cctccagatc
     5761 gctccacgcg gcagcggaga ggggagccag ttcacggtgc agattgtcca tcgggtgtgc
     5821 tccgcttcag actgccgatc cccaacgacg tgtcggggaa ccggggttgg ctgtcgggtg
     5881 ttgcggtggc ggcggcgtgt tgatcggtgg ctgctttccc cgattccacg ccgggtggtg
     5941 caggcaggtc atccaggaag tcagccgtgg ggacgtggaa caggcatccg gtgacaggcg
     6001 tggagaagtc caggatccga tcgtgagagg cgtccgcagt acccaggaac atccgttcca
     6061 gcatcgcctc cgtcaccgtc ggggtgcggg catagccgat gaagtaggtg ccgaactcgc
     6121 cgcggccaac agtgccgaag ggcatgttgt cgcggaggat ctcgcgttcc gtgccgtcgg
     6181 ggtcggtgat cgtagtgagg gcgacgtgcg aatccgacgg ctggctgttg tcgtccagct
     6241 cgatgtccga cagtttcgtc ctgccgatga tcttctcctg tgcctcgaca ggcaacgcgt
     6301 tccagccggc caggtcgtgc acgtacttct gcacgatcac gtaactcccg ccggcgaact
     6361 ctgcgtcctc atccccgatc aggaccgcgt tgctcgccgc ggcgccggtg gggttctccg
     6421 tgccgtcgac gaagccgagc aggtcacgtt tgtcgaagta ctggaagccg tgtacttcgt
     6481 cgcgcacggt caccgctgtc cccagccggg tcatgatctc cgtggcgagg gcgaaacaca
     6541 ggtccaggcg cgaagcgcgg atatggaaga gcaggtcgcc cggtgtcgac accgcgcggt
     6601 gcacaggccc gttcagttca cggaaggggt gcagttccgc ggggcggggc ccggcgaaaa
     6661 ggcgactcca tgcgtgcgat ccgattccgg tgacgcagct gagcctgccc tcgggctcgg
     6721 cgcggaagcc cgcagcccgt tgcagggagt tcaagtcgga cagcacgccc cgggtaaccg
     6781 cttcgccgcc agggtcgatc gtggcgacga ggaagatggc cgcgcttgtt aggggactaa
     6841 gaaccggctg cggtgtcggt gccgacgtct catcggtcat gtgccctgcc ccttccagcg
     6901 gagtgcccga ggtggcacgg gagcccagta cgcgtgtcgc gacgagcgac gtggatgcct
     6961 tggcggatcg gtccgaccca aagtagccct ttgccactgg tggccgcccg ctcactcggt
     7021 ttcgaccgcg ccgccttccg gcgtattgaa catgctcagg tactggccgt agccctccct
     7081 ctccagttcc tcaacaggga tgaagcgcag ggaggccgag ttgatgcagt accgcagtcc
     7141 gcccttgtcc cttggaccat ccgggaacag gtgcccgagg tggctgtccc ctttccccga
     7201 ccggacttcg acacggacca ttccgtggct ggtgtcggac cgctcgacga cgtggccgga
     7261 ctccaggggt ttcgtgaagc tgggccaccc tgtgcggctg tcgtacttgt ccgccgagga
     7321 gaacaggggc tcccctgaca cgatgtccac gtagatgcca gggaccttgt tgtcccagaa
     7381 ggcgttggcg aaggcgggct ccgtctcgtc ctgctgggtc acgcggtact gctgttctgt
     7441 gagctgggcg atgcgctcag cgtccttgtg gtactccgac atgcctacct cccaggcgac
     7501 gtggctgtcc ttctaggcat tcgtgtcacg ccccgccgct tccttacctc gcaacatgcg
     7561 atgtccagcg ccggaccatg cgtgcatggc ctgaagcgca aggctgccgg gtcaccgtgg
     7621 tcggggcgag gtgccctcgc cgccgtctcc ggcccgccgt accgggaagt gaggcgacga
     7681 gccggggcgg tggactgaag ggtgaggaaa ctggatgtcc cggcgctacg gctctcgtag
     7741 acctgctggt aaggctgggg agtaatgcgc cgctaaccgc atagagaccc ctggggggca
     7801 aagcggatgg aggccggtat gaccagcgga cagggcggcc ggttgatcgg cccgccaatc
     7861 gcagcggacg ccgcggccta cttcatcgac ccggcctaca gcaatgtcag tttcagtgcc
     7921 cggaaccgca tggcgaccag cacgcgcgga gcgttccgac ggttcgcggg cacgctcttc
     7981 ctcgacagcg agcggcccga gaggacggcg ctcgctttgt acgtgacgtc gtcgagtatc
     8041 gacaccggcc agaaggacag ggacgcggac ctgtgcagcg ctgctctcct cgacgccgag
     8101 cagtatccgc tcatgtcgtt ctggtcctct tcggccgagg ccgtggatac gaacctctgc
     8161 cgtctcgcgg gaagcctgcg ggtcaagaac atgacgatgc ctctcggcgt cgactgcgaa
     8221 taccggggcc gtacacacgg cccgcagggc gacgagcgcg tggggttcct agggcgctct
     8281 gtgctgaggc ggtcggaatg gggatccctg tggggcccgg tggtccacgc gggcgagtgg
     8341 atcgtgggtg acgaagtcga gctgctcttc gaggtgtccg cggtcaagcg ggcgcccatc
     8401 agatggtggc cctgacatga cccggcctga atgcggcgca agccgcgtct gcgctccagc
     8461 tcgcggaacg agacaccgag cgtcggcggc ctggggcgga ccccgccgga acatctcata
     8521 cccgtctacc ccacatcggc cggacagacc cgagctcgcg cccagcaccg tggagctgcc
     8581 agcgaacaca ggtctgtaca gcctcccccg actctcgcag ggccgtttcc cggcatcagg
     8641 ccagctcgag ccgtttcgcg cggtgtccga ggtacaagac gatcagaccg cacagtgcgg
     8701 caggggctac gaggatcatg aagagctgct cgtggccaat gccgccggcc agcatgcctc
     8761 cgacgatcat cgggccgacg attccaccga cgcggccgat gcccagcgcc cagccgacgc
     8821 ccgtggagcg tacttcttcc ggatacaagg ccgcagcgag cgcgatgacg ctcttctgcc
     8881 cgccgctgat ggtgcagccg atcaagaaga tggccgccag gaccatccag accggcgagc
     8941 ccagcaccag gcccatgagg accaggaagc cgcaaccgac gaagtagagc gtgctcaagg
     9001 agccgtaagc gccgagccgg tccatcgcgg gcccgatcac gaaggcgatc acgatgccgc
     9061 cgatggtcgt catggacgcg gcggtcgcca aggtgccggc ggagtacccg cgttcactga
     9121 ggatggtcgg catccagctc tggaggccgt agaacatcgc caagttgatc gcgaagacca
     9181 cccacagcag gactgtgccg agtagttgac ggccggtgag cagctcggtg accttgaccc
     9241 gcttgcccgg gtcggcgctc tccgcctcga tgtgcgcctc gcccgtctcg ggaagcatcc
     9301 ggtcgatccg tcggaggtgg gcgtatgcct tggcgttctg gccgcggcgc agcagatagg
     9361 agatcgactc gggcagtcgc caggccagta cggggagcat ggccaggggc agcacggcac
     9421 ccgcgacgaa gaccgagcgc cagccgtagg cggggatgag ccagccggcg gcgtagttgg
     9481 cggccacgaa tccgagtgag aagccgcagt agatcgccag aaccaggctg gcccgcaatc
     9541 gcttggggct gtactcggcg gtgagtgcga tggtgctcgg ggtggccgcg ccgaggccga
     9601 ttccggtgat gaaccgcatg atcatgagtt ggtcagggct ctgcgccccc accgagacca
     9661 gcgtcgagag cgagaagagc gcgactcccg ccatgaccag ccgtttgtgg ccgagcttgt
     9721 cggagagcgg agccagcagt aggtagccga tcatcaggcc gaccagcgcg gctgagaaga
     9781 tcgtagccat ggtgcccttg gacacgtccc agtcctgggt gatggccgga gccatgtagt
     9841 tgatcgcctg ggtatcgaac ccatcgagca gcatgaccag tgcgcacagt aggacggtac
     9901 gcagctggaa accgcccagt cggcgttcgt cgatgaagcc aggaagccgg atcggcttcg
     9961 agccggatac ggtggcggac cgagatgaag tggtttcgga cataatgccc tccaggtgga
    10021 gaacggttac tcgacgctga caggggcggc cacggccgag acgaacgcat cggagtggaa
    10081 ccggtccgga gccataccgt gctcgcgcgc cagctcctcg ccggcggttc gggtcattgc
    10141 ctcactgcca caggcgtaga tgtggtggtc gctcaggtcg gggtggtccg cgatcgcggc
    10201 tgcttgtacc caaccggtgg tgccttccca gccggcgtgt ggtcgggaga gcacgggggt
    10261 gaaccggaac caggggtagc gccgggtcca ggcttggaga gaagtgcggg cgtagaggtc
    10321 gtcgagagtg cgggcgcccc agtacaggtg gagcgggcgg gtcagtcgcc gggcgatgtg
    10381 gtcgaggacg atcgactgca tgggtgcgaa tccggtgccg gtggcgagca gaaggaccgg
    10441 gccgtcgccg tcctcgacga agaactcacc gaagggcgcc tcgatctcca cggtggcgtg
    10501 gaactccagc cgttgcagga tccgggcgga gaacacgccg ttgggttcgt gccggacgtg
    10561 cagttgggcg aggttgttgt gctggggtgc attggccagc gagtacgacc gggtatcgct
    10621 gccgtcgagg atgacgttga ggaactggcc ggccaggaag ggtgtccgcc ggccgatggg
    10681 gtaacgcagg tcgagcacgg tgacgccagg agcgacttgg cggcgacggt gcaccgtcgt
    10741 ggtcagccgc ttgcgcaccg gtggggtccg cgccgtgatc cggcgcggcg cgatctcgat
    10801 gtcgccggtg g
//
