LOCUS       NZ_BNBM01000024         9820 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence24, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000024
VERSION     NZ_BNBM01000024.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 151860)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 9820
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..9820
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="butyrolactone"
                     /region_number="1"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..9820
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..9820
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3926:4820](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3927..4820)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(312..1106)
                     /locus_tag="IE325_RS41025"
                     /old_locus_tag="GCM10018780_83090"
     CDS             complement(312..1106)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037154.1"
                     /locus_tag="IE325_RS41025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83090"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190075286.1"
                     /transl_table=11
                     /translation="MTQQPIALLNPHITELTAYQDQLTSLSAEAREPAGAGAARPRRAA
                     VRVLVVESDPKTAMSLVQRLRRHGCQAESVATGAKALQAHHNCDLILLDLELPDLDGLE
                     ICRSIRAVCDTPIIIVTARDSELERVLGLQAGSDDYLAKPYSFLELMARIEAVMRRARP
                     QQPRPQVIVRGLLRIDAGTREVSLGGRHIDVTRKEFDLLHLLASQPDKVISRRQLMMQV
                     WDDPWSRPGRTLDTHVSSLRNKLGSSRWVVTVRGVGFRLGHA"
     misc_feature    complement(1083..1085)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    1191..1207
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.97"
                     /tool="antismash"
     gene            1407..2078
                     /locus_tag="IE325_RS41030"
                     /old_locus_tag="GCM10018780_83100"
     CDS             1407..2078
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515159.1"
                     /locus_tag="IE325_RS41030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83100"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190075287.1"
                     /transl_table=11
                     /translation="MTKQERGTRTRHMLIRSAAEVFEQHGYERTRLADVSAHAGVSTGA
                     LHFHFKSKAALADAVESAASRSLHHAASSVGRHPVSALQTLTDISHIFALLLDRDVVVR
                     AGVQLGCDTVRDPTLNFHREWQDCVRRLLDRAAAEGSLADDVSQQDVTTTVVGATMGFL
                     SMRREGGEWLTHRSLTGFWRLLLPRVATPPLLGSLAPEGTRSVAGAFPSTARTVPERQP
                     Q"
     gene            complement(2105..3013)
                     /locus_tag="IE325_RS41035"
                     /old_locus_tag="GCM10018780_83110"
     CDS             complement(2105..3013)
                     /NRPS_PKS="Domain: PKS_ER (17-300). E-value: 2.1e-36.
                     Score: 117.6. Matches aSDomain:
                     nrpspksdomains_IE325_RS41035_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155344.1"
                     /locus_tag="IE325_RS41035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83110"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_190075288.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.8e-17, bitscore:
                     55.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIQVDRFGGPEVLTPRQVPEPVPGPGQSLITVEAAGVNFADAL
                     QAEGSYEGADQLPYVPGREVVGRTADGRRVAALTRGGYAELALADDTKTIDVPEELPAG
                     QVLALLMQGLTAWHLLRTAARLQPGESVVVHSAAGGVGSLAVQLAREFGASWVGAEVST
                     SAKRELALGLGADAVVEYPLDKPVDVVLDAVGGRLFDEGLGSLAVSGRLVTYGNASRAG
                     FTPLDPARLSRLGASVVGFWLRPVLARPGGFTEPLQELFSLTGQGRLRPVAGAEYPLAE
                     AGRAHADLLARRTMGKVILRP"
     aSDomain        complement(2114..2962)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS41035_PKS_ER.1"
                     /evalue="2.10E-36"
                     /label="IE325_RS41035_PKS_ER.1"
                     /locus_tag="IE325_RS41035"
                     /protein_end="300"
                     /protein_start="17"
                     /score="117.6"
                     /tool="antismash"
                     /translation="RQVPEPVPGPGQSLITVEAAGVNFADALQAEGSYEGADQLPYVPG
                     REVVGRTADGRRVAALTRGGYAELALADDTKTIDVPEELPAGQVLALLMQGLTAWHLLR
                     TAARLQPGESVVVHSAAGGVGSLAVQLAREFGASWVGAEVSTSAKRELALGLGADAVVE
                     YPLDKPVDVVLDAVGGRLFDEGLGSLAVSGRLVTYGNASRAGFTPLDPARLSRLGASVV
                     GFWLRPVLARPGGFTEPLQELFSLTGQGRLRPVAGAEYPLAEAGRAHADLLARRTMGKV
                     IL"
     CDS_motif       complement(2567..2629)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS41035_0001"
                     /evalue="1.40E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE325_RS41035"
                     /protein_end="149"
                     /protein_start="128"
                     /score="23.9"
                     /tool="antismash"
                     /translation="GESVVVHSAAGGVGSLAVQLA"
     gene            3099..3869
                     /locus_tag="IE325_RS41040"
                     /old_locus_tag="GCM10018780_83120"
     CDS             3099..3869
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (11-173). E-value: 3.7e-17.
                     Score: 54.8. Matches aSDomain:
                     nrpspksdomains_IE325_RS41040_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659168.1"
                     /locus_tag="IE325_RS41040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83120"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190075289.1"
                     /sec_met_domain="adh_short (E-value: 4.4e-37, bitscore:
                     121.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.9e-34, bitscore:
                     113.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITSGGLLLGKVVLITGASSGIGAAAAAVFAREGASVVLAARRED
                     RLAALTAELTGKGFDAAYVVADVTRADDMREAVAFTVDRHGRLDGAFNNAGIGGDQTPL
                     HEMQDDIYDSVIDTNVRGLWNCMRAEIAAMLASGGGAVVNNSSVGGLVAIPTAAPYVAA
                     KHAVVGFTRAAADEYARQGIRVNCVAPGSTRSEITADWYGRNPGLEEAIHAITPQGRTA
                     APEEIAEAATWLLSDRASYVTGVVMPVDGGFVNR"
     misc_feature    3120..3122
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       3132..3227
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS41040_0001"
                     /evalue="1.90E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE325_RS41040"
                     /protein_end="43"
                     /protein_start="11"
                     /score="10.9"
                     /tool="antismash"
                     /translation="VVLITGASSGIGAAAAAVFAREGASVVLAARR"
     aSDomain        3132..3617
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS41040_PKS_KR.1"
                     /evalue="3.70E-17"
                     /label="IE325_RS41040_PKS_KR.1"
                     /locus_tag="IE325_RS41040"
                     /protein_end="173"
                     /protein_start="11"
                     /score="54.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVLITGASSGIGAAAAAVFAREGASVVLAARREDRLAALTAELTG
                     KGFDAAYVVADVTRADDMREAVAFTVDRHGRLDGAFNNAGIGGDQTPLHEMQDDIYDSV
                     IDTNVRGLWNCMRAEIAAMLASGGGAVVNNSSVGGLVAIPTAAPYVAAKHAVVGFTRA"
     gene            complement(3927..4820)
                     /locus_tag="IE325_RS46765"
                     /old_locus_tag="GCM10018780_83130"
     CDS             complement(3927..4820)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041195.1"
                     /locus_tag="IE325_RS46765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83130"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_190075424.1"
                     /sec_met_domain="AfsA (E-value: 8.9e-13, bitscore: 41.6,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNILLPGCDHVDEAQGKGVPKEYVHLHREESVLVTGWSKDGDDQ
                     YSVGARWPAAEQGLPDPLLLTQTIRQSCLVIAHAERSVPLSHQTLMERMDFSLAPGFRA
                     LKNRPVDLLVKVSCRSTGRRSMRMELTLLHEKQTVATSVVSFSWIAPAVYRRLRGEYLD
                     VPWGRFPVPLPAPVEAHTVGRADTSCVVLAATDLPGRWQLRTDVDNKVLYDHPVDHVPA
                     LALIEGACQAAQGLMRPAVFTPVEVTSWYDRYIEFDAPCWIEAVVDSSADDGRTRVEVT
                     GVQRGATAFRVGLVGE"
     misc_feature    complement(4644..4646)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4810..4823
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    complement(4880..4893)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    4881..4894
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.61"
                     /tool="antismash"
     misc_feature    complement(4882..4895)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.13"
                     /tool="antismash"
     misc_feature    4883..4896
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            4922..5608
                     /locus_tag="IE325_RS41050"
                     /old_locus_tag="GCM10018780_83140"
     CDS             4922..5608
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988493.1"
                     /locus_tag="IE325_RS41050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83140"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190075290.1"
                     /transl_table=11
                     /translation="MARQERAIRTRGVILEAAATVFDELGYEAATISEILKRAGVTKGA
                     FYFHFPSKEDLAWGLLDQAVTTEGVRPQPIKLQEVVDTMLIMAHRLPREPVFSSALRLS
                     VDRNSQRLFGTRWPDWISLLTSLLGEAKERGEIYPYLDETTTARLLLSAWTGVQIVSEG
                     LPEEHDLSTEVSRMLQLMLPSIAVPTVLSQLEVFADRGARLLAAALPDTEADDTTVEKN
                     AATTAG"
     gene            complement(5971..7203)
                     /locus_tag="IE325_RS41055"
                     /old_locus_tag="GCM10018780_83150"
     CDS             complement(5971..7203)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IE325_RS41055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83150"
                     /product="MFS transporter"
                     /protein_id="WP_190075291.1"
                     /transl_table=11
                     /translation="MSALAQEPAPAAIRPGTLPLLLFASTLTVMAGSILAPVIQVIRGD
                     LGVGGTAGGLIITTHSLAIAVTSPLAGWMLDRWGVRLPLAGGLVLYGVAGGAGLLVDSY
                     PALIATRAVFGAGAALVFSGTTVALLNMYRGPAQDRAMGWRGTATSLGGVLWPLLAGAI
                     GGISWHLPFGIYLVGVPLGIATALMLPRTAPASSGRAGGPAPGVWAMLREHRLLLVWYA
                     LQFCGSLLLYVLVVFLPQRLAEVGVEDPLLVSFYTVGMSAAMSLIGLAYASMRARLAYS
                     VLLRGSLSLWVAGFLLLAVAPNAPLLFLAPLLFGLGQGVFFPVTTVLVGEGVPAEIRGK
                     ATSLSGTATFAGQFASPLLIGPLIQATSAITGFLVAATVPAVAVILLVLSRADTTDSPS
                     DEPAPAAARVK"
     gene            complement(7200..7898)
                     /locus_tag="IE325_RS41060"
                     /old_locus_tag="GCM10018780_83160"
     CDS             complement(7200..7898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042148.1"
                     /locus_tag="IE325_RS41060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83160"
                     /product="YitT family protein"
                     /protein_id="WP_229912420.1"
                     /transl_table=11
                     /translation="MSKSVTTQATARRPLPGDLRERLYRYALYLTGCVVFASGATLFIH
                     SELGVDPLDVLSLGVLEHLPLTIGVVQALVAAVCIAIWSVWNRRRPVLMPFVTFLLCGS
                     LIDLLLLADLSWIASVPSLCVAVVLCAYGSALIIMSGTGIRAMDLIVITLNQRWKVPFW
                     GAKVGVEAVLLTLGWLLGGPVGIGTLAFLVFVDGLIQPFMSFNSRALNLTNHGLTHTGG
                     VGGPVLQATR"
     misc_feature    complement(7572..7574)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8002..8322)
                     /locus_tag="IE325_RS41065"
                     /old_locus_tag="GCM10018780_83170"
     CDS             complement(8002..8322)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.5"
                     /locus_tag="IE325_RS41065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83170"
                     /product="VOC family protein"
                     /protein_id="WP_190075292.1"
                     /transl_table=11
                     /translation="MFGKLTVIKIYCDDLDTMVAFYRDRLGLRIREEYPGVSVVFDTGH
                     DGELIIQKGDQPNAIAFTEVDIPAAHKEIGDLGPTGIVPHKTGERFEITDPEGNQLIFV
                     NA"
     misc_feature    complement(8297..8310)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            8546..9187
                     /locus_tag="IE325_RS41070"
                     /old_locus_tag="GCM10018780_83180"
     CDS             8546..9187
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025605.5"
                     /locus_tag="IE325_RS41070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_83180"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190075293.1"
                     /transl_table=11
                     /translation="MTAPTPTRTGRPAKRTAIDCAARAVFGREGYTRASMDSIAAEAGV
                     SKRTIYNHYQDKEQLLLSVLQESTHALSAHQQELIDRHLSDPADLRAGLLALGRALAAP
                     QSGFEQHFALVRVIFAEASRLPAEVIGGWRAEGPRRTQALLAEHFTTLTQAGRLRADDP
                     AQAAAHFTQLAMSEAYERSFHGALPLPSTELDELVASGVNAFLRLYEAVD"
     misc_feature    9241..9257
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    9374..9388
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
ORIGIN
        1 tggaggtctc ctagatacga gagacccacc tgtcaataac gtccgtcagt tttagaccta
       61 gggcgtgccc ggcggatcat gccggcgtcg cggggcctgg cacgcactcc cccactgcct
      121 gaagggcgtg gggggacccc cagccgcgtt gtcgtcactc gccgcctccc ccacgctcga
      181 acaacctcgc gcggggggac ccccatcgcg tcggctccct cctccgcctt gcagctgcac
      241 gcaccagacc ccgctcacca gcgttgatga ggctccgttc cttgcagccg ccctgatccg
      301 ccggacaggc cctaggcgtg cccgagccgg aagccgactc cccgtaccgt caccacccag
      361 cggctggagc cgagcttgtt gcgcagactg ctcacatggg tgtcgagcgt gcggccgggc
      421 cgtgaccagg ggtcgtccca gacctgcatc atcagctggc ggcgggagat gaccttgtcc
      481 ggctgggagg ccagcaggtg cagcaggtcg aactccttac gggtcacatc gatgtgccgc
      541 ccgccgagac tgacctcgcg cgtgcccgcg tcgatccgca gcaggccgcg gacgatgacc
      601 tgcgggcggg gctgctgcgg acgggcccgg cgcatgacgg cctcgatacg ggccatcagc
      661 tccagaaagc tgtacggctt cgccaggtag tcgtccgatc cggcctgcag acccagcact
      721 cgttcgagtt cggagtcccg ggccgtgacg atgatgatcg gggtgtcgca gacggcgcgg
      781 atgctccggc agatctccag gccgtccagg tcgggcagtt cgaggtcgag gaggatcagg
      841 tcgcaattgt ggtgcgcctg cagtgccttg gcgccggtgg ccacgctctc ggcctggcag
      901 ccgtgccgcc gcagccgctg caccaggctc atggcggtct tcgggtcgct ctcgaccacg
      961 agaacccgga cagcggcccg ccgtggacgg gccgcgccgg cgcccgccgg ctcccgcgcc
     1021 tcggcggaca gcgatgtcaa ctggtcctga taggcggtca gctcggttat gtgtgggttg
     1081 agtaaggcga tgggctgctg cgtcatctgc tgctcctgca catccgcgat acggacagtc
     1141 atccccggta gagcttttgg cccgatcacg ataaaaacca gctcgccggt ttgtcaacga
     1201 ctcccaaaat gtgcaaagtt cggccaggaa acgcggtgtt tacgccatat tctcgatcca
     1261 gtgcgctacc cagccccacc tgggcacctc cgtatacaaa ccagtgcgct ggtttaattg
     1321 ggccatctcg cagacataca acgtctgctt cgtcttcccc tgccggcctc ggcgccgcag
     1381 gagcagttcc ccgactggag ccaccggtga ccaaacagga acggggcacc cgcacccgcc
     1441 acatgctgat ccgttcggcg gccgaggtgt tcgaacagca cgggtacgag cggacccgcc
     1501 tggccgacgt cagtgcgcac gccggtgtca gcaccggcgc cctgcacttc cacttcaaga
     1561 gcaaggcggc cctggccgac gccgtggagt cggcggcctc ccgttccctg catcacgcgg
     1621 cgagcagcgt cggccgccat ccggtgagcg cactgcagac gctcaccgac atctcacaca
     1681 tcttcgccct cctcctcgac cgtgacgtgg tggtgcgcgc cggggtccaa ctgggctgcg
     1741 acaccgtccg ggaccccacc ctgaacttcc atcgggagtg gcaggactgt gtacgacgcc
     1801 tgctggaccg tgccgcggcc gagggcagcc tcgccgacga cgtgtcccag caggatgtga
     1861 cgacgaccgt ggtcggggcg accatgggct ttctgtccat gcgccgggag ggcggcgagt
     1921 ggctgacaca ccgttcgctc accgggttct ggcggctgct cctgccccgt gtggccactc
     1981 ccccgctcct cggctcgctg gccccggagg gcacgcgctc cgtggcgggc gcctttccgt
     2041 ccacggcccg gaccgtgccg gagcgtcagc cgcagtagcc ccggggcgga ccgcctcgcc
     2101 gggctcacgg ccgcaggatc accttgccca tggtgcgccg ggccagcagg tccgcatggg
     2161 cccgccccgc ctcggccagc ggatactcgg cgccggcgac cggccgcagc cgcccctgcc
     2221 cggtcagcga gaacagctcc tggagcggct cggtgaagcc gccgggccgg gccagcacag
     2281 ggcgcagcca gaagccgacg accgaggcgc cgagccggct gagccgcgcg gggtccagcg
     2341 gagtgaaccc ggcgcgggag gcgttgccgt aggtcaccag gcggcccgac accgcgaggg
     2401 agccgaggcc ctcgtcgaag agccggccgc cgaccgcgtc gaggacgacg tcgaccggct
     2461 tgtccagcgg atactcgacc accgcgtcgg ctccgaggcc cagggcgagt tcccgcttgg
     2521 cggaggtgga gacctcggcc ccgacccacg acgccccgaa ctcccgggcc agctgcaccg
     2581 cgaggctgcc gacgccgccc gccgcggagt ggacgacgac gctctcgccg ggctgcagcc
     2641 gggccgcggt gcgcagcaga tgccaggcgg tcagcccctg catgagcagg gccagcacct
     2701 ggcccgcggg cagctcctcg ggtacgtcga tcgtcttcgt gtcgtcggcc agggcgagtt
     2761 cggcgtaacc gccccgggtc agggccgcca ccctgcggcc gtcggcggtc cggccgacca
     2821 cctctcggcc cggcacatac ggcagctggt ccgcgccctc gtaggagcct tcggcctgga
     2881 gggcgtcggc gaagttgacg cccgcggcct cgacggtgat cagcgactgg ccggggccgg
     2941 ggaccggctc gggcacctgt cgcggtgtca gcacctcggg accgccgaag cggtcgacct
     3001 gaatggcacg catggtcagt gaactccgtt cgttcggcaa aggcccggta acccgcgtgt
     3061 catgaactct tccaggacga cctgcaagac tgcgaggcat gatcacatcg ggtggactgt
     3121 tacttgggaa agtggttctg atcacagggg cgagcagcgg cataggtgcc gcggccgctg
     3181 ccgtcttcgc ccgtgagggc gcctcggtcg tgctcgccgc acgccgggag gacagactcg
     3241 cggccctcac cgccgagttg accggcaagg gcttcgacgc ggcatacgtc gtagccgatg
     3301 tcacacgcgc cgacgacatg cgcgaagcgg tcgccttcac cgtggaccgg cacggccggc
     3361 tcgacggggc gttcaacaac gccggcatag gcggcgacca gacccccttg cacgagatgc
     3421 aggacgacat ctacgactcc gtcatcgaca ccaacgtccg cggactgtgg aactgcatgc
     3481 gggccgagat cgcggccatg ctggcgagcg gcggcggcgc cgtagtgaac aacagcagcg
     3541 tcggcggcct ggtggccata ccgaccgccg cgccctatgt cgccgccaag cacgcggtgg
     3601 tcggtttcac ccgggccgcc gccgacgagt acgcgcgtca gggcatccgg gtgaactgcg
     3661 tggccccggg ctcgacccgc agcgagatca ccgccgactg gtacggccgc aaccccggcc
     3721 tggaggaggc gatccacgcg atcacccccc agggccgtac ggcggccccc gaggagatcg
     3781 ccgaggccgc gacctggctg ctcagcgacc gcgcgtcgta tgtcaccggc gtggtgatgc
     3841 cggtggacgg cggtttcgtc aaccgttgat gcgagagggg aagccgcccg gttcacggac
     3901 ggcttccctg ccgcgccccc gaggggctac tcaccgacca gaccgaccct gaacgccgtg
     3961 gccccccgct gcacacccgt gacctcgacc cgcgtacgac cgtcgtcggc cgacgagtcg
     4021 accaccgcct cgatccagca gggcgcgtcg aactctatgt accggtcgta ccaactggtc
     4081 acctcgaccg gcgtgaacac cgcgggccgc atgagcccct gtgccgcctg gcatgccccc
     4141 tcgatcaacg ccagcgcggg cacatggtcg acgggatggt cgtagaggac cttgttgtcg
     4201 acgtcggtgc gcagctgcca ccggcccggc aggtcggtgg cggcgagcac cacgcatgag
     4261 gtgtccgcac gtcccacggt gtgcgcctcg acgggcgcgg ggagggggac ggggaaccgg
     4321 ccccagggaa cgtccagata ctccccccgc agccggcggt acaccgcggg agctatccag
     4381 ctgaaggaga ccacggacgt ggcgacggtc tgcttctcgt gcagcagggt gagttccatc
     4441 cgcatcgagc ggcggcccgt acttcgacac gagaccttga caagaaggtc aaccggtcgg
     4501 tttttgagag cacgaaaacc gggagcgagg gagaaatcca ttcgctccat caatgtctga
     4561 tgcgacaacg gaaccgaccg ttccgcgtgc gctatgacca ggcagctctg ccggatcgtc
     4621 tgggtgagca gcagcggatc gggtaacccc tgctccgccg caggccaacg cgcgcctacc
     4681 gagtactggt cgtcaccgtc cttggaccag ccggtgacca ggacggattc ctcccgatgc
     4741 aggtggacgt actctttggg aacgcccttc ccctgggcct cgtcaacatg atcgcaacca
     4801 ggcagcaaaa tatttgacat aaatccccct ctgtctggcg acaactgctc cgaccctcgt
     4861 taagataccg gcttgccggt cttttttaaa gaaatgattg attgcggtga ggagaacagc
     4921 cgtggcacga caggagcggg cgatcaggac ccgcggcgtc atcttggagg ccgccgcgac
     4981 ggtcttcgat gaactcggct acgaagccgc gaccatctca gagatcctga agcgggccgg
     5041 tgtgaccaag ggagccttct acttccactt cccgtccaag gaggacctgg cctgggggct
     5101 gctcgaccag gcggtgacga ccgaaggcgt ccggccgcag ccgatcaagc tccaggaggt
     5161 ggtggacacg atgctgatca tggcgcaccg gctgccccgg gagcccgtgt tcagctccgc
     5221 gctgcggctg tcggtggacc gcaactcgca acgcctgttc ggtacgcgct ggccggactg
     5281 gatctcgctg ctgacctccc tgctgggtga ggcgaaggag cgcggcgaga tctacccgta
     5341 tctcgacgag acgacgaccg cccggctgct cctgtccgcc tggaccgggg tccagatcgt
     5401 gtccgaaggg ctgccggagg agcacgacct gtcgaccgag gtctcgcgaa tgctccagct
     5461 gatgctgccg agcatcgccg tgcccacggt actgagccaa ctggaggtct tcgccgaccg
     5521 aggcgcccgc ctcctcgccg ccgccctgcc ggacaccgaa gcggacgaca ccacggtcga
     5581 gaagaacgcc gccaccaccg ccggctgaga ccccgaccat gccaccggac ggcgagcccg
     5641 tcgcgcccgc ccggctgacc accacgcccg gtacggtcgc ggccggttga ggccccgtcc
     5701 actccggccc caccgccgta cggctaccgc cgggccgctg cccggcggcc cggccgtgtc
     5761 ctgcgggcgg cggcggtgcc caagcgcaca cggagccccg gccgttcctc acctgatgcg
     5821 ggtggaggag gccggggagc accgacagga ccaccgccac ccgcggctca ggcctcatcc
     5881 gctccggccc caccgccgta cggcagccgc cgggccgctg tccggcgggc gggtgcgatg
     5941 cccgtgcgca ccgcgagccc tggccgctgc tcacttgacc cgggcggcgg ccggggcggg
     6001 ttcgtcggac ggggagtccg tcgtgtccgc gcggctgagg accaggagga tcaccgccac
     6061 ggccggtacg gtcgccgcga ccaggaagcc ggtgatggcc gaggtggcct ggatgagcgg
     6121 gccgatcagc agtggggagg cgaactggcc ggcgaaggtg gcggtgcccg acagggaggt
     6181 ggccttgccg cggatctccg cgggcactcc ctcgccgacc agcaccgtgg tcaccgggaa
     6241 gaacacgccc tggccgaggc cgaacagcag tggtgccagg aacagcagcg gcgcgttggg
     6301 cgccacggcc agcagcagga acccggccac ccacagcgac agcgatccgc gcagcagcac
     6361 gctgtaggcg aggcgggccc gcatcgaggc gtaggcgagg ccgatcaggc tcatcgcggc
     6421 ggacatgccc acggtgtaga aggagaccag cagcgggtcc tcgacgccga cctcggccag
     6481 ccgctggggg aggaagacca ccagcacgta cagcagcaga gagccacaga actgcagcgc
     6541 gtaccagacc agcaggagcc ggtgttcgcg cagcatggcc cagacgccgg gcgccggtcc
     6601 gcccgcgcgg ccggagctgg ccggtgcggt gcggggcagc atcagggcgg tggcgatgcc
     6661 gaggggcaca ccgaccaggt agatcccgaa cggcagatgc caggagatcc cgccgatcgc
     6721 cccggccagc agcggccaga ggactccgcc cagactggtg gccgtaccgc gccagcccat
     6781 cgcgcggtcc tgcgccggcc cccggtacat gttcagcagg gccacggtgg tgcccgagaa
     6841 gaccagggcc gctccggcgc cgaagacggc acgggtggct atgagcgccg gataactgtc
     6901 gacgaggagc ccggcaccgc cggccacccc gtacagcacc aacccgcccg ccagcggcag
     6961 ccgtacgccc cagcggtcca gcatccatcc ggccagcgga ctggtgacgg cgatggcgag
     7021 gctgtgggtg gtgatgatga ggccgccggc ggtgccgccg accccgaggt caccgcggat
     7081 gacctggatg accggcgcga ggatggagcc cgccatcacc gtcagggtcg aggcgaagag
     7141 gagcagcggc agcgtcccgg ggcggatcgc cgccggtgcc ggttcctgtg cgagcgcgct
     7201 catcgggtgg cctgcagaac ggggccgccg actccaccgg tgtgcgtcag accgtggttg
     7261 gtcaggttca gcgcgcggga gttgaaggac atgaagggct ggatcagtcc gtcgacgaag
     7321 accaggaagg ccagggtccc gatgccgacc gggccgccga gcagccagcc gagggtgagc
     7381 agtacggctt cgacgccgac cttggcaccc cagaagggca ccttccagcg ctggttgagg
     7441 gtgatcacga tgaggtccat ggcgcggatg ccggtgccgc tcatgatgat cagggcggag
     7501 ccgtaggcgc acagcacgac cgcgacacac agggacggca cggaggcgat ccagctcagg
     7561 tcggccagca gtaacaggtc gatgaggctg ccgcagagaa ggaaggtgac gaacggcatc
     7621 aggaccgggc gccggcggtt ccacaccgac cagatggcga tgcacacggc cgcgacgagc
     7681 gcctggacca cgccgatggt gagcgggagg tgctccagca cgcccagcga gaggacgtcc
     7741 agggggtcca cgccgagttc ggagtggatg aacagggtgg cgccggacgc gaagaccacg
     7801 catccggtca gatagagggc gtagcggtac aggcgctcgc gcaggtcacc ggggagcggg
     7861 cggcgggcgg tcgcttgggt ggtcactgac ttggacatga tgaggctcct cgacaaagac
     7921 ccctgcggac cgtccggcag acgacggggg atgacggagc ggacggcccg caggggagtt
     7981 tcgggttgga gacggcttcg gtcaggcgtt gacgaagatc agctggttgc cctcggggtc
     8041 ggtgatctcg aagcgctcgc ccgtcttgtg cggaacgatg ccggtcgggc ccaggtcgcc
     8101 gatctccttg tgggcggcgg ggatgtccac ctcggtgaag gcgatggcgt tgggctggtc
     8161 gcccttctgg atgatcagct cgccgtcgtg gccggtgtcg aagacgaccg agaccccggg
     8221 gtactcctcg cggatcctca gaccgagccg gtcgcggtag aaggcgacca tcgtgtccag
     8281 gtcgtcgcag tagatcttga tcacggtcag cttgccgaac atcgcgtgtt ccctttcatg
     8341 agcgcccctc agcaggggat ccgacgcttg gcggggcatc gcccgaccga gaaggaaact
     8401 acacggtgca gtgcagaaag taaaccgctg agtgcaaaag ggccgggtct gtaaactaaa
     8461 cggtatagtt tcgcccgaga cacacaggcg ccccgaacat cagcgcgatc gaacaaggcc
     8521 agcgcggtcg aaggagtgaa ccaccatgac ggcccccacc ccgacccgaa caggacggcc
     8581 cgcgaaacgc acggcgatcg actgcgccgc ccgcgccgtc ttcggccgcg agggatacac
     8641 gcgcgccagc atggacagca tcgccgcgga ggcgggcgtc tccaagcgca cgatctacaa
     8701 ccactaccag gacaaggagc aactcctgct gagcgtcctc caggagagca cgcacgcact
     8761 ctcggcccac cagcaggaac tcatcgaccg ccacctgtcc gaccccgccg acctgagagc
     8821 cggactcctg gcactgggcc gcgccctcgc cgccccgcag agcgggttcg agcagcactt
     8881 cgccctggtg cgggtcatct tcgcggaggc gtcccggctg cccgccgagg tcatcggcgg
     8941 ctggcgcgcc gagggcccgc ggcgcaccca ggccctgctc gccgagcact tcaccaccct
     9001 gacgcaggcc ggccggctcc gcgcggacga ccccgcgcag gccgccgccc acttcaccca
     9061 gctcgccatg tccgaggcct acgagcgctc cttccacggc gctctcccgc tgccgtcgac
     9121 cgagctggac gagctggtcg cctccggcgt gaacgcgttc ctgcggctgt acgaagcggt
     9181 cgactgaccg acgtcgcgcc tccgccctcg tagcacgggg aagacttttt gctccgcacg
     9241 gtgtagttta ctttctgtcg gggcactcgc cgctccgtcc ggccgcaagc cgtctctccc
     9301 ggaggtagcg catgaccagc cagcccctgt ccgtcgccgt catcatcggc agcgcacgcg
     9361 gcggacgcct cggtgacaag gtcggccact ggttcgccaa gcaggcccag gcacgcgacg
     9421 acatgacggt cgatgtgatc gacgtcctgg agcacccgtt gccggtcgcc ctgcccgcga
     9481 tgaacgagga gccggccgac cacgtacgga ccgtcaagga cgccctgtcc gcccggctga
     9541 cggccgccga cgccttcatc gtcgtcaccc ccgagtacaa ccactcctac cccgcctccc
     9601 tgaagaacgt catcgactgg cacctgcggg agtgggccgc caagccggtc ggcctcgtgt
     9661 cctacggtgg catgggcggc ggtctgcgtg ccgccgagca cctgcgccag gtcttcgccg
     9721 aggtgcacgc gatgaccgtg cgcgagatgg tcagcctgca caacccctgg ggttccttca
     9781 cccacgccga cgacgccccg gagggcgcgg acgccgccgc
//
