LOCUS NZ_BNBM01000022 30112 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence22, whole genome shotgun sequence. ACCESSION NZ_BNBM01000022 VERSION NZ_BNBM01000022.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 179530) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 96057 Orig. end :: 126169 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000022.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..30112 /candidate_cluster_numbers="1" /contig_edge="False" /product="NI-siderophore" /region_number="1" /rules="IucA_IucC" /tool="antismash" cand_cluster 1..30112 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="IucA_IucC" /kind="single" /product="NI-siderophore" /protoclusters="1" /tool="antismash" protocluster 1..30112 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[14000:16112](-)" /cutoff="20000" /detection_rule="IucA_IucC" /neighbourhood="14000" /product="NI-siderophore" /protocluster_number="1" /tool="antismash" proto_core complement(14001..16112) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="IucA_IucC" /neighbourhood="14000" /product="NI-siderophore" /protocluster_number="1" gene 486..2033 /locus_tag="IE325_RS39910" /old_locus_tag="GCM10018780_80690" CDS 486..2033 /codon_start=1 /gene_functions="transport (smcogs) SMCOG1005: Drug resistance transporter, EmrB/QacA" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004924596.1" /locus_tag="IE325_RS39910" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80690" /product="MFS transporter" /protein_id="WP_190075085.1" /transl_table=11 /translation="MTTSQLIKNPKPGAARREGHPGIALTVIAACQLMVVLDATIVNIA LPHIQDALKFSTTDLTWVVSSYTLTFGGLLLLGGRAGDILGRRRVFMTGILLFTLASLL GGLAQEPWQLLAARVLQGMGGAIASPTSLALITTTFPEGPERNRAFGVFAAVSAGGGAI GLLAGGMLTEWLDWRWVLFVNVPIGIAIAVLAPMYISESERHNGRFDIAGAVTSTAGMA SLVYGFIRAADEGWRDSLTIGSFGAAVVLLLAFAFIESRAKEPITPLRMFADRNRSGTY VIMLSLAAAMFGMFFYIVLFVQNVLQYSPIEAGLAFLPVTVVIALGAGLSQRFLPVLGP KPFMLAGSALAAIGLAWQTLITADSSYVGGVLGPMLVFGFGMGLNFVTLTITAVSGVAQ HEAGAASGLLNATQQVGGSLGLSILTTVFGSASKDEAEKQLPQFMAEGSAEQKAEFAQT HQLPGRWGHEVLTQGISTGFVAAAAMSVLALATAWFVIRVRKSDLEALSGTAGPMAG" misc_feature 499..512 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 14.54" /tool="antismash" misc_feature complement(505..514) /note="TFBS match to ToxT, Regulator of MSHA biosynthesis, confidence: weak, score: 14.62" /tool="antismash" gene complement(2406..3311) /locus_tag="IE325_RS39915" /old_locus_tag="GCM10018780_80700" CDS complement(2406..3311) /EC_number="3.2.2.-" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010034880.1" /locus_tag="IE325_RS39915" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80700" /product="ADP-ribosylglycohydrolase family protein" /protein_id="WP_190075086.1" /transl_table=11 /translation="MTADSSPEGRLDRALASLRGLAVGDALGSQFFVPVNYPLLKRREL PPGPWQWTDDTEMACSVVAVLAAHHRIDQDALARSFAEHHDFDRGYGPAVNRLLRLVRE GGDWRELSAALFNGQGSWGNGAAMRIAPLGAWYADDPEQATHQAEISAYPTHQHREAVV GAMAVAAAAALASAPGGPPSPEALLDGVIALVPKSAVGAGLRRARDMLDYADASTVAAV LGCGRRTTAHDTVPFALWSAARALGDYEQAFWTTAQVGGDVDTTCAIVGGVIGSGKAGA MPVEWAERTEALPEWAPTSV" gene complement(3324..3983) /locus_tag="IE325_RS39920" /old_locus_tag="GCM10018780_80710" CDS complement(3324..3983) /GO_function="GO:0016791 - phosphatase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1101: phosphoglycerate mutase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973214.1" /locus_tag="IE325_RS39920" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80710" /product="histidine phosphatase family protein" /protein_id="WP_190075087.1" /transl_table=11 /translation="MARPRRIVLVRHGESTGNVDDTVYEREPDHALALTERGWRQAEET GKRLREVFGRERVSVYVSPYRRTHETLRAFHLDPELIRVREEPRLREQDWGNWQDRDDV RLQKSYRDAYGHFFYRFAQGESGADVYDRVGNFLESLYRSFEAPDHPSNVLLVTHGLAM RLFCMRWFHWTVAEFESLSNPGNAEMRMLVLGDDGKYTIDRPFERWRDPEPYGITG" gene complement(4103..4708) /locus_tag="IE325_RS39925" /old_locus_tag="GCM10018780_80720" CDS complement(4103..4708) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1258: Antibiotic biosynthesis monooxygenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007385166.1" /locus_tag="IE325_RS39925" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80720" /product="YdbC family protein" /protein_id="WP_190075088.1" /transl_table=11 /translation="MLVKWIRCTVVDRRGFERGQRKWAGLLGEPGFRGQGGGWSRGRQG VAHVFSFWESRSFYDSFMARSHDRLAVAQSGTFKDAQVKLFDYRFDVKTGFEPRFTDAD LVRVAHCRIHEDRAEHFTLMQEKVWNPAMAGSPGMVRGLFGEAPGHEFLVLSMWQSAAE HGKYRTERVERLALRAQTEADVAALTGDIVELEATWTV" gene 4865..5398 /locus_tag="IE325_RS39930" /old_locus_tag="GCM10018780_80730" CDS 4865..5398 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010034869.1" /locus_tag="IE325_RS39930" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80730" /product="TerD family protein" /protein_id="WP_190075089.1" /transl_table=11 /translation="MNAINKGIRKVEISLKWDPSPAGQPPTDLDIVAATYLASDPYGDP AYVVHFDSRSPDGTIYLNRDSKDGKGFGWDEVLTVELDRLDSRYARVMVGVVIQQHPAE RTFVSVIKPALRIREGYTVMAEDDFGGVLGATAATVAEFVREGSNTWGFHSGIHGFEDD PATFTAVMGRARQP" gene complement(5544..8438) /locus_tag="IE325_RS39935" /old_locus_tag="GCM10018780_80740" CDS complement(5544..8438) /EC_number="1.17.4.1" /GO_function="GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA]" /GO_process="GO:0006260 - DNA replication [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030467.1" /locus_tag="IE325_RS39935" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80740" /product="vitamin B12-dependent ribonucleotide reductase" /protein_id="WP_190075090.1" /transl_table=11 /translation="MTETASGPARSSRAKGTKATKGLRIERIHTTPGVHPYDEVAWERR DVVMTNWRDGSVNFEQRGVEFPDFWSVNAVNIVTSKYFRGAVGTPQREVSLKQLIDRIV KTYRKAGEDYKYFASPADAEIFEHELAYALLHQIFSFNSPVWFNVGTPQPQQVSACFIL AVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADAS AGTIKSGGATRRAAKMVILDVDHPDIEDFIETKVKEEEKIRALRDAGFDMDLGGDDITS VQYQNANNSVRVNDTFMKAVESGGKFGLTSRMTGEVIEEVDAKALFRKMAEAAWACADP GIQYDDTINHWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDGKGNQSFD VERFAKVVELVITAMDISICFADFPTQKIGENTRAFRQLGIGYANLGALLMATGHAYDS DGGRALAGAITSLMTGTSYRRSAELAAVVGPYDGYARNATPHLRVMKQHADANGKAVRM DDLDTPIWAAATEAWQDVQRLGEKNGFRNSQASVIAPTGTIGLAMSCDTTGLEPDLALV KFKKLVGGGSMQIVNGTVPQALRRLGYQEEQIEAIVAHIADHGNVVDAPGLKHEHYEVF DCAMGERSISAMGHVRMMAAIQPWISGALSKTVNMPESATVEEVEEIYFEAWKMGVKAL AIYRDNCKVGQPLSAKTKEKEKTEITEKAEATIRETVEKVVEYRPVRKRLPKGRPGITT SFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETY VSKFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHL ETGSYEPNEDEVDVEGLAQSAPRAQELKAVATPKAEASAPKPAPQQAHTSAELVEMQLG IQADAPLCFSCGTKMQRAGSCYICEGCGSTSGCS" gene complement(8603..9169) /gene="nrdR" /locus_tag="IE325_RS39940" /old_locus_tag="GCM10018780_80750" CDS complement(8603..9169) /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /GO_function="GO:0140110 - transcription regulator activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene="nrdR" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020139144.1" /locus_tag="IE325_RS39940" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80750" /product="transcriptional regulator NrdR" /protein_id="WP_190075091.1" /transl_table=11 /translation="MHCPFCRHPDSRVVDSRTTDDGTSIRRRRQCPDCSRRFTTVETCS LMVIKRSGVTEPFSRTKVINGVRKACQGRPVTEDALAQLGQRVEEAVRATGSAELTTHD VGLAILGPLQELDLVAFLRFASVYRAFDSLEDFEAAIAELREATGRAADDDDREAVVDA VTGGQEDERGSGGTAQVPVPANAAE" misc_feature 9277..9291 /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: strong, score: 24.62" /tool="antismash" misc_feature 9308..9322 /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: strong, score: 26.06" /tool="antismash" misc_feature 9648..9661 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 15.92" /tool="antismash" misc_feature 9657..9672 /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 23.09" /tool="antismash" misc_feature complement(9658..9671) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: medium, score: 20.93" /tool="antismash" misc_feature 9658..9671 /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: weak, score: 19.77" /tool="antismash" gene 9732..10511 /gene="lexA" /locus_tag="IE325_RS39945" /old_locus_tag="GCM10018780_80760" CDS 9732..10511 /EC_number="3.4.21.88" /GO_function="GO:0004252 - serine-type endopeptidase activity [Evidence IEA]" /GO_process="GO:0009432 - SOS response [Evidence IEA]" /GO_process="GO:0045892 - negative regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene="lexA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019526308.1" /locus_tag="IE325_RS39945" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80760" /product="transcriptional repressor LexA" /protein_id="WP_190075092.1" /transl_table=11 /translation="MTTTADSATITAQDRSQGRLEPVHAMNESMSPEGHKRSLPGRPPG IRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALERKGF LRRDPHRPRAYEVRGSDQAASVQPTDTAGKPAASYVPLVGRIAAGGPILAEESVEDVFP LPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMLDGEATVKRF KREDGHVWLLPHNAAYEPIPGDDATILGKVVAVLRRV" gene complement(10693..12678) /locus_tag="IE325_RS39950" /old_locus_tag="GCM10018780_80770" CDS complement(10693..12678) /EC_number="3.6.4.12" /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0004386 - helicase activity [Evidence IEA]" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997359.1" /locus_tag="IE325_RS39950" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80770" /product="ATP-dependent DNA helicase" /protein_id="WP_190075093.1" /transl_table=11 /translation="MTKPSLPELLHAAVTAVGGTERPGQVTMAESVAEAIDGSSHLLVQ AGTGTGKSLGYLVPALAHGERVVVATATLALQRQLVERDLPRTVDALHPLLRRRPEFAM LKGRSNYLCLHRLHEGVPQDEEEGLFDQFEAAAPTSKLGQDLLRMRDWADETETGDRDD LAPGVSDRAWAQVSVSSRECLGASKCAYGAECFAEMARERAKLAEVVVTNHALLAIDAI EGAPVLPQHEVLIVDEAHELVSRVTGVATGELTPGQVNRAVRRAAKLVNEKAADQLQTA AEGFERLMELALPGRLEEIPEDLAYALMALRDACRTVISAIGATRDKSVQDEDAVRKQA LASVETVHDVAERITNGSEWDVVWYERHDRFGASLRVAPMSVSGLLREKLFADRSVVLT SATLKLGGDFNGVGASMGLAPEGTEGDDIPQWKGLDVGSPFEYPKQGILYVAKHLSRPA RDGDRADMLDELTELIQAAGGRTLGLFSSMRAAQLAAEELRSRIPEYPILLQGEETLGE LIKNFAADPKTCLFGTLSLWQGVDVPGPSCQLVVMDKIPFPRPDDPLMSARQKAVEEAG GNGFMAVAATHAALLMAQGAGRLVRASGDRGVVAVLDQRLATARYGSYLKASLPDFWYT TDRNQVRRSLAAIDASAQQTEAAQPE" gene complement(13068..13961) /locus_tag="IE325_RS39955" /old_locus_tag="GCM10018780_80780" CDS complement(13068..13961) /EC_number="2.3.1.-" /GO_function="GO:0016746 - acyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1203: putative siderophore biosynthesis protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016641006.1" /locus_tag="IE325_RS39955" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80780" /product="GNAT family N-acetyltransferase" /protein_id="WP_190075094.1" /transl_table=11 /translation="MPPTDATANAGFAPGTEIGIKTSPSAREDRGHAARHPAADAGADI EDTLDLRLPDEFRAFFANDIGTEPSGTASSGAEHAGAEDTGIGAERSLNTGIGVPASAV PKDTDLLGEVADWGPVSTSAGVLHLVPVRIERDLSIISRWMNDPAVTAFWGLAGSQNAT EEHLHSQLHGDGRSVPCMGLLEGTPMSYWEIYRADLDPLARHYPARPHDIGVHLLIGGL GDRGRGLGGTLLRAVADLALDNRPACARIVAEPDIRNTPSVAAFLTAGFRFSVEIELPV KRAALMIKDRSLRHLL" misc_feature complement(13926..13939) /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: weak, score: 18.12" /tool="antismash" gene complement(14001..16112) /locus_tag="IE325_RS39960" /old_locus_tag="GCM10018780_80790" CDS complement(14001..16112) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) NI-siderophore: IucA_IucC" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014675452.1" /locus_tag="IE325_RS39960" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80790" /product="IucA/IucC family siderophore biosynthesis protein" /protein_id="WP_373315319.1" /sec_met_domain="IucA_IucC (E-value: 5.9e-69, bitscore: 225.5, seeds: 168, tool: rule-based-clusters)" /transl_table=11 /translation="MNSTPTTDGRPDIHPHLLQRDSSVARLPQEEPPTTAQVPVRTPTQ AGAPALERLHGLTSDLLEHPDPHTAAHAAAVENLLRCWVRETGVTSLRNGILRIPLPAT GTTLLVPVHYWSPTGWHRFGLPRLAAAPDEPPPIDAVTLAALLTREATSRSAPPGGDAT SALTPTAILTSDAAPAPSASAHDGESRTSAGSETSSAPKPTSVTSPVMSAATELVARVA DSAQRTATFIRERREKAADGPDLFLTAEQALLLGHPLHPTPKSREGLSEAEAWLYSPEL RGCFPLHWLAVAPSLLATDSAWTERGRVIPAPQLTARLAGPDLPLPGSYAALPLHPWQL REIRHRPEVASLLDAGLLVDLSAHGAPWHPTSSVRTVHRSQAPAMLKLSLGLRITNSRR ENLRKELHRGVEVHRLLRSGLSTHWQAAHPAFDIVRDPAWLAVDGLDGDPVPGLDVMIR HNPFRPTDDVSCVAGLVSPLPHVPQSGTSTARPRSDREPLRSRLAELVTHLAARTGRSR GAVAAEWFLRYLEHVVRPVLWLDAEAGVALEAHQQNTLLLLDSDGWPAGGRYRDNQGYY FRESRRAELDTRLHGIGERSDTFVSDEVTDERFAYYLAINNVLGLIGAFGSQHLADEQL LLAAFRRFLGEVASGPARLRTSLPAHLLDSPVLRCKANLLTRLHGLDELVGPVDTQSVY VTIANPLHS" gene complement(16363..18201) /locus_tag="IE325_RS39965" /old_locus_tag="GCM10018780_80800" CDS complement(16363..18201) /GO_function="GO:0008483 - transaminase activity [Evidence IEA]" /GO_process="GO:0019491 - ectoine biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_3 (46-380). E-value: 2.5e-89. Score: 291.5. Matches aSDomain: nrpspksdomains_IE325_RS39965_Aminotran_3.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1013: aminotransferase class-III" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020125071.1" /locus_tag="IE325_RS39965" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80800" /product="diaminobutyrate--2-oxoglutarate transaminase family protein" /protein_id="WP_229912378.1" /sec_met_domain="Aminotran_3 (E-value: 2.3e-80, bitscore: 263.4, seeds: 13, tool: rule-based-clusters)" /transl_table=11 /translation="MAVTESVRGGMSESAGVGAVHEGILRRQSARESAARTYARALPIV PVRARGLTIEGADGSRYLDCLSGAGTLALGHNHPVVLEAIRGVLDSGAPLHVLDLATPV KDDFITELFRTLPPGLADNARVQFCGPAGTDAVEAAFKLVRAATGRTGILAFSGAYHGM TAGALEASGGAFDVRVARLPYPQDYRCPFGIGGERGAELAARWTESVLDDPKSGVRRPA GMILEPVQGEGGVIPAPDGWLRRMRQITADRSIPLIADEVQTGVGRTGSFWAVEHSGVT PDVMVLSKAIGGSLPLAVIVYRDDLDAWQPGAHAGTFRGNQLAMAAGTATLAYVRENRL AERAAELGSRMLHQLQGLAGEYACIGDVRGRGLMIGVEVVEPEAEPERDEKQSAVWAPE EGFDGLTASGRHGGAADQSAPGASLEPGWPGAGVGAPGALDPTRSAGSPPMGLARAGGG AGTAAAVQRDPARSPRPAAPELAAAIQRECLRRGLIVELGGRHSSVVRLLPPLTISDEQ ASAVLDRLADAVDAVSRGKTGPDRSHGRLHLPHPGQARHSDRADRAEHGGHGEHGDLDG SADLDDSADRADRDESADRADHDESADRADRAERAR" aSDomain complement(17062..18063) /aSDomain="Aminotran_3" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS39965_Aminotran_3.1" /evalue="2.50E-89" /label="IE325_RS39965_Aminotran_3.1" /locus_tag="IE325_RS39965" /protein_end="380" /protein_start="46" /score="291.5" /tool="antismash" /translation="VRARGLTIEGADGSRYLDCLSGAGTLALGHNHPVVLEAIRGVLDS GAPLHVLDLATPVKDDFITELFRTLPPGLADNARVQFCGPAGTDAVEAAFKLVRAATGR TGILAFSGAYHGMTAGALEASGGAFDVRVARLPYPQDYRCPFGIGGERGAELAARWTES VLDDPKSGVRRPAGMILEPVQGEGGVIPAPDGWLRRMRQITADRSIPLIADEVQTGVGR TGSFWAVEHSGVTPDVMVLSKAIGGSLPLAVIVYRDDLDAWQPGAHAGTFRGNQLAMAA GTATLAYVRENRLAERAAELGSRMLHQLQGLAGEYACIGDVRGRGLMIGVEVV" gene 18773..19783 /locus_tag="IE325_RS39970" /old_locus_tag="GCM10018780_80810" CDS 18773..19783 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1287: AraC family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014178112.1" /locus_tag="IE325_RS39970" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80810" /product="GlxA family transcriptional regulator" /protein_id="WP_190075095.1" /transl_table=11 /translation="MKRHVVAVAVADGAPTLELAVPCEVFGIDRSDLVDPWYELRLCAA QPGPLRTAAGLIVPTSDGLDRLGEADTVVVAACSRAVQLDPSADLLEAVRRAHELGRRI VSICSGAYVLAAAGLLDGRRATAHWMSAMDFTHRFPDVDFDPASLYIQDGTILTSAGTG SAIDLCLHLVRQDHGSAVANEVARRMVVPPHREGGQAQYARPPVRVRKASDTLAPVLEW ARRHLHEQLTVPQLAREAGLSERTFARRFRETFGTTPLQWILQERVRLAQELLETTDDA VESVAQRTGFGGATNLRYHFGRLTGVSPQTYRHVFRHRTAQQRRAGWAEEMPSER" gene 20012..21232 /locus_tag="IE325_RS39975" /old_locus_tag="GCM10018780_80820" CDS 20012..21232 /EC_number="3.4.21.-" /GO_function="GO:0004252 - serine-type endopeptidase activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973224.1" /locus_tag="IE325_RS39975" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80820" /product="serine protease" /protein_id="WP_190075096.1" /transl_table=11 /translation="MRSIRPSFTARRGRSARRRFSPVPLVALTAALALTVTACESGDAE AGADAGASAAAGGEGKITIPDDIKDQLKEHGIDIDKWKDGAWKNWDRDDWLREAKDYIN PIIEGLWDPDRMRDAEDPDRGVDDSDLAGDQGVTDPTPQPVDAQAVSPAYHANAPEAGK VFFDSPEGTMVCSATVVKDPAHPGKSNMVWTAGHSVHAGKSGGWYRNIAFVPSYNDKAM SADAMKGATKEQAAPYGVWWAEWAQTSDQWIAQGGPTGGDGASYDFAVLHVKPEAGGNG KSLEETVGSALPVDFNAPAVPDVDSIKAIGYPAAAPFDGQKLYQCQDQPGRLSLKTSDP TMYRIGCTMTGGSSGGGWIAAGSDGKPALVSNTSIGPVDAGWLAGPRLGKEAKTIFDGV SEKFAGQ" misc_feature 21441..21455 /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 18.37" /tool="antismash" gene 21446..22645 /locus_tag="IE325_RS39980" /old_locus_tag="GCM10018780_80830" CDS 21446..22645 /EC_number="3.4.21.-" /GO_function="GO:0004252 - serine-type endopeptidase activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018564698.1" /locus_tag="IE325_RS39980" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80830" /product="serine protease" /protein_id="WP_190075097.1" /transl_table=11 /translation="MRSTSTPETPRRRRHSALAATGLLAALALTATACSAEEASDRADA AASQAADAAGDGKIEIPAELADKLKEHGIDIDEWKDGAWKDWDKDKWLSEAKDFVNPVI EGLWKPDRMQSAKEANKTITTQDAAADQGVSDPEPALVQATAEKTPYHQNAAPVGKVFF DTPDGPAVCSGTVVKDVNHPGKSNLVWTAGHCVHAGQGGGWYRNIAFVPAYNDLGKSEA ELGSATNAEIAPYGNWWADWVSTSNEWIQGGSETGGDGAAYDYAVLHVKPESGAKSLEE TTGALDVDFTAPSATEVDTMGAWGYPAAPPFNGLQMYKCLDRPGRLSLSPALPTMYRIG CTMTGGSSGGGWFRVVNGRTTLVSNTSIGPEDHTWLAGPQLGTGAESLYQNMSKTYGGR " gene complement(22741..24234) /gene="hflX" /locus_tag="IE325_RS39985" /old_locus_tag="GCM10018780_80840" CDS complement(22741..24234) /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /codon_start=1 /gene="hflX" /gene_functions="other (smcogs) SMCOG1227: ribosome biogenesis GTP-binding protein YsxC" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019072894.1" /locus_tag="IE325_RS39985" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80840" /product="GTPase HflX" /protein_id="WP_190075098.1" /transl_table=11 /translation="MTSSSSFSQDNQRFAHTHAEGRRADALMEEDVAWSHEIDGDRDGD QFDRSDRAALRRVVGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTAQDSENSLAELAA LAETAGALVLDGVIQRRDKPDAATYIGSGKASELRDIVLETGADTVICDGELSPGQLIH LEDVVKVKVIDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGG KGGGLATRGPGETKIETDRRRIREKMAKMRREIAEMKTGRDIQRQVRRRNKVPSVAIAG YTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHL VEAFRSTMEEVGESDLILHVVDGSHPAPEEQLAAVREVIRDVGAIDVPEIVVINKADAA DPLTLQRLMRIEKRSIAVSARTGQGIQELLALIDNELPRPSVEIEALVPYTHGKLVARA HTEGEVISEEHTPEGTLLKVRVHEELAADLAPYVPTPTA" gene complement(24365..25948) /locus_tag="IE325_RS39990" /old_locus_tag="GCM10018780_80850" CDS complement(24365..25948) /EC_number="3.4.11.-" /GO_function="GO:0004177 - aminopeptidase activity [Evidence IEA]" /GO_function="GO:0008237 - metallopeptidase activity [Evidence IEA]" /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007491622.1" /locus_tag="IE325_RS39990" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80850" /product="M1 family metallopeptidase" /protein_id="WP_190075099.1" /transl_table=11 /translation="MLLTPRNEVRRAPRPSRRLRVPAMVSAAVSLCLLAASAPATPLGI GDRLYPHLGNPGYDVASYDLSFTYPGKNDKPLQAVTTIDAWTTEDLDRVNLDFAHGKVE SVVVDGEPAAFSSAGEDLVVTPSEALPEGTWTRITVRHTSDPVYGEKREGGWVRTTDGL AMANQADAAHVVFPCNDHPSDKALFTIRVTAPNGYTAVANGLPTGVDRAGRSTTWTYRT RHPMATELAQVSIGRSEVVHRKGPHGLPVRDVVAREDRERLEPWLKKTPGHLAWMEKKV GRYPFETYGLLMAHASTGFELETQTLSLFERELFTQTAFPKWYVESIMVHELAHQWFGD SVSPRTWSDLWLSEGHATWYEALYAAETADRPMEARMKAAYSASDRWRAAGGPPAAPKA PAAGKKNGIFRPNVYDGAALILYALRQEIGRQAFERLERLWVSRHQDGVASTADFVALA EEVSGRDLDGFLHAWLYGKKTPPMPGHPEWKSLDPTKAVKKPATKPVKKPAGKTTGKTA GKTAGRTAAK" gene complement(26071..28236) /locus_tag="IE325_RS39995" /old_locus_tag="GCM10018780_80860" CDS complement(26071..28236) /EC_number="2.7.6.5" /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0005525 - GTP binding [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0015970 - guanosine tetraphosphate biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030459.1" /locus_tag="IE325_RS39995" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80860" /product="bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase" /protein_id="WP_190075100.1" /transl_table=11 /translation="MSAEATNSATPGPVAGPVPAAVPRRKARARIDLRRLGRAALLGPA PRRGLPDAIGHVVDAHRAHHPDADLEPLRRAYVLAESSHRGQMRKSGEPYITHPLAVTL ILAELGAETTTLTASLLHDTVEDTDVTLDQVREQFGEEVRFLVDGVTKLEKVDYGAAAE PETFRKMLVATGNDVRVMSIKLADRLHNMRTLGVMRPEKQARIAKVTRDVLIPLAERLG VQALKSELEDLVFAILHPEEYEHTRELIVENASRADDPLAEIADEVRGVLREADIQAEV LIRPRHFVSVHRVSRKRGRLRGSDFGRLLVLVNEDADCYGVLGELHTCMTPVVSEFKDF IAVPKFNLYQSLHTAVARADGQVAEVLIRTHQMHRVAEAGVVALGNPYASSPEEQTVDG ERADPTRPGWLSRLLDWQEAAPDPDTFWSTLREDLAQDREITVFRPDGGTLGLPEGATC VDAAYAQYGEDAHACIGARVNGRLATLSTVLRDGDTVQLLMGQDPASEPSREWLEHAHT PAARIAIQRWLAAHPPQAGAEAKEPGVAFRGAADGPTAEGSAARQATEGAVGRSTANVL ADRPGANVRLAGCCTPVPPDEITGFSVRGGVVTVHRVSCAAVARMKSGGRAEVDVRWGD TTECRVTLVAESFVRPHLLADLTEAMAMEGAEIVSATVEPPTQQRVRHTYTVQLPDAAL LPGLMRAMRNVGGVYDVSRAQPQTQGA" misc_feature complement(28375..28390) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 16.26" /tool="antismash" misc_feature complement(28382..28397) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 19.88" /tool="antismash" misc_feature 28446..28458 /note="TFBS match to LuxO, Repressor of luminescence, confidence: weak, score: 17.65" /tool="antismash" gene complement(28533..29402) /gene="dapF" /locus_tag="IE325_RS40000" /old_locus_tag="GCM10018780_80870" CDS complement(28533..29402) /EC_number="5.1.1.7" /GO_function="GO:0008837 - diaminopimelate epimerase activity [Evidence IEA]" /GO_process="GO:0009089 - lysine biosynthetic process via diaminopimelate [Evidence IEA]" /codon_start=1 /gene="dapF" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007385151.1" /locus_tag="IE325_RS40000" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80870" /product="diaminopimelate epimerase" /protein_id="WP_190075101.1" /transl_table=11 /translation="MSTRIAFLKGHGTENDFVIVPDPENAIDLPPATVAALCDRRAGIG GDGLLHVVRSAAHPEAQDMAADAEWFMDYRNGDGSIAEMCGNGVRVFARYLQHAGHVTE GDLAVATRGGVKTVHIDKDGDVTVGMGRARLPEGDVTVSVGERSWPARNVNMGNPHAVA FVDDLAHAGNLYSPPPFSPASVYPDGVNVEFVVDRGPRHVALRVHERGAGETRSCGTGA CAVAVAAARRDGADPALTGAPATYTVDVPGGTLVITERPDGEIEMTGPAVIVAEGEIDA DWLETIAR" gene complement(29448..29951) /locus_tag="IE325_RS40005" /old_locus_tag="GCM10018780_80880" CDS complement(29448..29951) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018547385.1" /locus_tag="IE325_RS40005" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_80880" /product="hypothetical protein" /protein_id="WP_190075147.1" /transl_table=11 /translation="MEAGPRDTAQGTEHVTTDTGERKPEGDRPIPDALDETEGGVTDDG PEPEEMYDSGPEVEVELRPQRRLRIWQLAPIVGLAAVGSLMFAFPLAFDFGDSGAVIAM LGLLICSCAAGWGMMAARRVGYTWPGLPQRGSERRLDWRVVIAYVLVVAAIVVLAVWRV ARLR" ORIGIN 1 gtagacacag cgccagcaga tcctcgcgga cactcccgag gtcgggggcc gactcgaaac 61 gcggcagtcc cgcccgtagc gcgtcggcga cgagatcctc cttggacggc cagcgacgat 121 agacggcggc cttgccggtc tgcgccccgg ccgcgacgcc ttccatcgtg aggccgttcc 181 agccgacggt gctgagctgt tccagtgcgg catcgaggat cgcgcgttcg agcacggcgc 241 cgcgccggcg gggggaagcc gtccgagcgg aggcggccgt ccagcgcgag gtaaccatca 301 atgtgtctcc aacgaacaaa aggaagctgg gattccgggg acttgggatc gccacgcgcc 361 aactacgggg gacaggacgc gcgacgacaa tgcgagtgaa cgcttgcgtt cactactggg 421 gactcactac ggttgacgcg acagtgaacg cgagcgttca ctaaggcact tgtgggggac 481 ccatagtgac aacctctcag ttgatcaaaa atccgaaacc aggtgcggcc cgccgggagg 541 gacatcctgg catcgcgctc accgtcatcg cggcctgcca actcatggtg gtactcgacg 601 cgacgattgt gaacatcgca ctcccgcaca ttcaagacgc actgaagttc agcaccaccg 661 acctcacgtg ggtcgtcagc tcctacacgc tcaccttcgg cggcctgctg ctcctcggcg 721 gtcgcgccgg cgacatcctc ggccgacgcc gggtcttcat gaccggcatc ctgctgttca 781 cgctcgcctc gctgctcggc ggactcgccc aggaaccctg gcagttgctg gccgcgcgcg 841 tgctccaggg aatgggtggc gcgatcgcct cgcccacttc gctggcgctg atcaccacca 901 cgttccccga aggcccggaa cgcaaccggg cgttcggcgt cttcgcggcc gtatccgcgg 961 gcggtggtgc catcggtctg ctcgcgggtg gcatgctcac ggagtggctc gactggcggt 1021 gggtgctctt cgtcaatgtg cccataggca tcgcgatagc cgtgctcgcg ccgatgtaca 1081 tcagcgagtc cgaacgccac aacggacgtt tcgacatcgc gggcgcggtg acctcgacag 1141 cgggtatggc ctctttggtc tacggcttca tccgtgcggc ggacgagggc tggcgcgaca 1201 gcctgaccat cggttccttc ggcgccgcgg tcgtcctgct gcttgccttc gcgttcatcg 1261 aatcgcgggc gaaagagccc atcaccccgc tcaggatgtt cgccgaccgc aaccgctcgg 1321 gcacatacgt gatcatgctc agcctcgctg cggcgatgtt cggcatgttc ttctacatcg 1381 tcctgttcgt gcagaacgtg ctgcagtaca gcccgatcga ggccggtctc gccttcctgc 1441 cggtgacggt cgtcatcgcg ctcggggcgg gcctgtcgca gcgtttcctg ccggtgctcg 1501 gccccaagcc gttcatgctc gcgggttcgg cgctcgcggc gatcggattg gcctggcaga 1561 ccctcatcac cgccgacagc tcctatgtcg gcggagtgct cggcccgatg ctggtgttcg 1621 gcttcggtat gggtctgaac ttcgtgacgc tgacgatcac cgcggtctcc ggtgtcgccc 1681 agcacgaggc gggtgccgcg tccgggctcc tcaacgccac ccagcaggtg ggcggttcgc 1741 tcggcctgtc catcctgacg acggtgttcg gctcggccag caaggacgag gcggagaagc 1801 aactgccgca gttcatggcg gagggctcgg cggagcagaa ggcggagttc gcccagacgc 1861 atcagctccc tggccggtgg ggccacgagg tgctcaccca gggcatctcc acgggcttcg 1921 tggcagcagc cgcgatgtcc gtactcgccc tggccaccgc atggttcgtg atccgggtgc 1981 gcaagagcga tctggaagcc ctctccggga cggcgggtcc gatggccggc tgaccgggcc 2041 gggcccgcac tgggccgcgg atggccggat cgcgtccggg ggaccgaccg cgagggcgac 2101 gcaccggcca tccgcaccac cctcgtggcg accttcgccg gttgagcccc gacggtgcgg 2161 ggaagatcga gccgaccgag cgtggcagcg gcagctacca gcagcagcac gcccagcgcc 2221 gatgtgaacc acatatcccc accccctgca cccctcgtgt gtcatctgcg tgtgcggccc 2281 cagcagcctc acaccaaccg ccacgacaac ggacaggcgg tcacgcagag ttcccgagat 2341 gcacggaaag ttatcgcggg ctggcttcgg cgggacgcgg aaccctgttg caccccctgt 2401 cggtgtcaca ccgacgtcgg cgcccactcc ggaagtgcct cggtccgctc cgcccactcc 2461 accggcatcg ctccggcctt cccggagccg atgaccccgc ccacgatggc gcacgtggtg 2521 tccacgtcac cgccgacctg cgcggtcgtc cagaaggcct gctcgtagtc accgagagcg 2581 cgcgccgccg accacagggc gaagggcacg gtgtcatgag ccgtcgtacg ccgtccgcag 2641 cccaggacgg ccgcgacggt gctggcgtcg gcatagtcga gcatgtcccg ggcacgccgt 2701 agtcctgctc cgaccgcgct cttcggcacg agggcgatga cgccgtcgag aagcgcttca 2761 gggctgggcg gaccaccggg ggcggacgcc aacgcggcgg ccgcggcgac ggccatggct 2821 ccgacgacgg cctcgcggtg ctgatgtgtg gggtaggcgg agatctctgc ctggtgggtg 2881 gcctgctcgg ggtcgtccgc gtaccaggcc ccgaggggtg cgatgcgcat cgcggcgccg 2941 ttgccccagg agccctggcc gttgaagagc gcggccgaca gttcgcgcca gtcaccgccc 3001 tcgcggacca ggcgcagcag tcggttgacc gcggggccgt agccccggtc gaagtcgtgg 3061 tgctcggcga aggagcgggc cagggcgtcc tggtcgatgc gatggtgggc ggccaggacg 3121 gcgaccacgg agcacgccat ctcggtgtcg tccgtccact gccaggggcc gggcgggagc 3181 tcgcgtcgct tgagcagcgg gtagttcacc ggcacgaaga actgcgagcc gagcgcgtcc 3241 cccaccgcga gtccgcgcag gctggcgagg gcgcggtcca ggcgcccttc gggagaggag 3301 tcagcggtca tcgccctgcc actctatccg gtgatcccgt acggttccgg gtcacgccag 3361 cgttcgaacg gccggtcaat cgtgtacttg ccgtcgtccc cgagaacgag catccgcatc 3421 tcggcgttcc ccgggttcga cagcgactcg aattccgcga ccgtccagtg gaaccagcgc 3481 atgcagaaca gccgcatggc cagtccatgg gtcacgagca gcacgttcga cgggtgatcg 3541 ggcgcctcga agctgcggta aaggctctcc aggaagttgc cgacccggtc gtacacgtcg 3601 gcgccggact cgccctgggc gaagcggtag aagaagtggc cgtaggcatc ccggtaggac 3661 ttctggaggc gtacgtcgtc gcggtcctgc cagttccccc agtcctgctc ccgcaggcgg 3721 ggctcctcac gtacccgtat gagctcgggg tccaggtgga aggcccgcag cgtctcgtgc 3781 gtgcggcgat aaggcgagac gtacacgctg acgcgctcgc ggccgaacac ctcccgcaga 3841 cgtttaccgg tctcctccgc ctgccgccag ccccgctcgg tcagggccag cgcgtggtcg 3901 ggctcacgct cgtaaacggt gtcatcaaca ttgcccgttg actccccgtg tcggacaagg 3961 acgatgcgcc gtggtcgtgc catgccaaaa ccctagatcg accgacggca gatcgagcac 4021 tcgtacgggc tccatacggc gtaggtcaca catttactgc atcacgagtc acattgaggc 4081 acacgcgtag cgggtccgga tttcaaaccg tccaggtggc ttcgagctcc acgatgtcac 4141 ccgtaagggc cgcgacatcc gcctccgtct gggccctcag cgccagccgc tccacgcgct 4201 cggtgcggta cttgccgtgt tccgcggccg actgccacat cgacagcacc aggaactcat 4261 gccccggtgc ctcaccgaac agcccgcgga ccataccggg agatccggcc atggcaggat 4321 tccagacctt ctcctgcatg agcgtgaagt gctcggcccg gtcttcatgg atacggcagt 4381 gggccacccg gacgaggtcc gcgtcggtga aacgcggctc gaagccggtc ttcacatcga 4441 agcggtagtc gaagagcttg acctgcgcgt ccttgaaggt gcccgactgg gccaccgcca 4501 gtctgtcgtg agagcgggcc atgaaggagt cgtagaagga gcggctctcc cagaacgaga 4561 agacatgcgc caccccctgc cgcccccggc tccagccacc cccctgcccc cgaaatcccg 4621 gctcccccag aagccccgcc cattttcgct gcccccgctc gaaaccgcgg cggtccacca 4681 cggtgcagcg aatccacttg accagcaccg cgccatggta aggccactcg gcgtggcgtc 4741 ggtcacgctc ggccgcagag ctcaccggcg cgcgatccca cgcgcgtggc aggatggaca 4801 accggccttg tccacggggc agttcggact gagggcatac gcgttacggg gaaggggaag 4861 cctggtgaac gccatcaaca aggggatccg gaaggtcgag atctcactca agtgggaccc 4921 gagtccggcc ggacaaccgc ccaccgatct cgacatagtc gccgcgacct atctggcgag 4981 cgatccctac ggcgatcccg cctacgtggt gcacttcgac agccgttctc ctgacggcac 5041 catctacctc aaccgggaca gcaaggacgg caagggcttc ggctgggacg aggtgctgac 5101 cgtggagctc gaccggctcg acagccggta cgcgcgcgtg atggtcggcg tcgtgatcca 5161 gcagcacccg gcggagcgca ccttcgtcag cgtcatcaag cccgccctgc gcatccgcga 5221 gggctacacc gtcatggccg aggacgactt cggcggcgtg ctcggggcga ctgcggccac 5281 ggtcgcggag ttcgtacgcg agggatcgaa cacgtggggt ttccactcgg gcatccacgg 5341 tttcgaggac gacccggcga cgttcaccgc ggtcatgggc agggctcgcc agccctgagc 5401 cagccctgag agtggctcgc acacgcgcgt ggacgtaact cgcccccgcg cgggccgtac 5461 aacgaggagg ggcgccgaca tgtcgtcgac acccctcctt tgagctatct gccgtcagag 5521 cccatcaggg ccgcccggca ggatcagctg cagccactgg tcgagccgca gccctcgcag 5581 atgtagcagg agccggcccg ctgcatcttc gtgccgcagg agaagcagag cggggcgtcg 5641 gcctggatgc ccagttgcat ctccacgagc tcggcgctgg tgtgcgcctg ctgcggtgcg 5701 ggcttcggcg cgctggcctc ggccttcggc gtggcgacgg ccttcagctc ctgggcgcgc 5761 ggcgccgact gggccaggcc ctcgacgtcg acctcgtcct cgttgggctc gtaggagccc 5821 gtctcgaggt gacgctgacg ctcctcggcg gagtggatgc cgagcgcgga gcgcgtctcg 5881 aacggcagga agtccagcgc caggcggcgg aagatgtagt cgacgatcga ctgcgccatc 5941 cgcacatccg ggtcgtccgt catgccggcc ggctcgaagc gcatgttcgt gaacttcgag 6001 acgtacgtct ccagcggcac gccgtactgg aggccgacgg agaccgcgat cgagaaggcg 6061 tccatcatgc ccgcgagcgt cgagccctgc ttggacatct tcaggaagac ctcgccgaga 6121 ccgtcgtccg ggtaggagtt ggcggtcatg tagccctcgg cgccgccgac ggtgaaggac 6181 gtggtgatgc cgggacggcc cttcgggagg cgcttgcgga ccgggcggta ctcgacgacc 6241 ttctcgaccg tctcacggat ggtggcctcg gccttctccg tgatctcggt cttctccttc 6301 tccttggtct tcgcggagag aggctggccg accttgcagt tgtcgcggta gatggcgagc 6361 gccttgacgc ccatcttcca ggcctcgaag tagatctcct cgacctcctc gacggtcgcc 6421 gactccggca tgttgaccgt cttggacagg gcgccggaga tccacggctg gatcgcggcc 6481 atcatgcgga cgtggcccat cgcggagatg gagcgctcgc ccatggcgca gtcgaacacc 6541 tcgtagtgct cgtgcttgag gcccggggcg tcgacgacat tgccgtggtc ggcgatgtgg 6601 gcgacgatcg cctcgatctg ctcctcctgg tagcccaggc ggcgcagggc ctgcgggacg 6661 gtgccgttga cgatctgcat cgagccgccg ccgaccagct tcttgaactt gaccagcgcg 6721 aggtcgggct caagaccggt ggtgtcgcag gacatcgcca gaccgatggt gccggtcggg 6781 gcgatgacgg acgcctggga gttacggaaa ccgttcttct caccaaggcg ctgcacgtcc 6841 tgccaggcct ccgtggcggc ggcccagatc ggcgtgtcga ggtcgtccat gcggacggcc 6901 ttgccgtttg cgtcggcgtg ctgcttcatg acgcgcaggt gcggcgtcgc gttgcgggcg 6961 tagccgtcgt acgggccgac gaccgcggcg agttcggcgg aacggcggta cgacgtgccg 7021 gtcatcaggg aggtgatggc accggccagg gcacggccgc cgtccgagtc gtacgcgtgg 7081 ccggtcgcca tcagcagggc gccgaggttg gcgtagccga tgccgagctg gcggaacgcg 7141 cgcgtgttct caccgatctt ctgcgtcggg aagtccgcga agcagatgga gatgtccatc 7201 gcggtgatga cgagctcgac gaccttcgcg aagcgctcga cgtcgaagga ctggttgccc 7261 ttgccgtcgt ccttgaggaa cttcatcagg ttcagcgagg cgaggttgca ggacgtgttg 7321 tccaggtgca tgtactcgct gcacgggttc gagccgttga tacggccgga ctccgggcac 7381 gtgtgccagt gattgatggt gtcgtcgtac tggatgccgg ggtcggcgca ggcccaggcg 7441 gcctcggcca tcttgcggaa cagggccttg gcgtcgacct cttcgatgac ctcgccggtc 7501 atacgggagg tcaggccgaa cttgccgccc gactcgaccg ccttcatgaa cgtgtcgttc 7561 acacggaccg agttgttggc gttctggtac tggacggacg tgatgtcgtc gccgcccagg 7621 tccatgtcga agcccgcgtc gcgcagggcg cggatcttct cctcttcctt caccttggtc 7681 tcgatgaagt cctcgatgtc ggggtggtcg acgtcgagga tgaccatctt ggcggcgcga 7741 cgcgtggcgc cacccgactt gatcgttcct gcggaggcgt cggcaccacg catgaaggag 7801 accggaccgg aggcgttgcc gccggaggag agaagctcct tggaggagcg gatgcgggag 7861 aggttcaggc cggcgccgga gccgcccttg aagatcatgc cctcttcctt gtaccagtcg 7921 aggatcgact ccatggagtc gtcgacggcc aggatgaagc aggccgagac ctgctgcggc 7981 tggggcgtgc ctacgttgaa ccacacaggg ctgttgaagc tgaagatctg gtgcaggagg 8041 gcgtacgcca gctcgtgctc gaagatctcg gcgtcggcgg gcgaagcgaa gtacttgtag 8101 tcctcgccgg ccttccgata cgtcttcaca atgcggtcga tgagctgctt gaggcttacc 8161 tcgcgctgcg gggtgccgac ggcaccgcgg aagtacttgc tggtgacgat gttgaccgcg 8221 ttcaccgacc agaagtcggg gaactcgacg ccgcgctgtt cgaagttcac agagccgtcg 8281 cgccagttgg tcatgacgac gtcacggcgc tcccaggcca cctcgtcgta cgggtgcacg 8341 ccgggggtgg tgtggatgcg ctcgatacgc agtcccttgg tcgccttggt gcccttggcg 8401 cgggaactcc gtgccggacc gctcgccgtc tctgtcatgc cgcctccctg tacgggctaa 8461 aacgccctga agtgccccga tgttccctgt ggcacgtgtt ctgtctattg ctgcgggcac 8521 cctctggtcg ccgcccgcag caggtcttgt gtcgccgccc tctcggccgg atccggggtc 8581 tgacgcctgg atccggctcg ccctattcgg cggcgttggc gggtacgggg acctgtgcag 8641 tccctccgga cccgcgctcg tcttcctggc cccccgtgac tgcgtccaca acggcttcgc 8701 ggtcgtcgtc gtccgcggcc cgccccgtcg cctccctcag ttccgcgatc gcggcctcga 8761 agtcctcgag cgagtcgaag gcccggtaga cggaggcgaa tcgcagaaag gcgacgaggt 8821 cgagctcttg caacgggccg agtatggcca gccccacgtc gtgggtggtc agctcggcgc 8881 ttccggtggc ccgcaccgcc tcctcgaccc gttggccgag ctgggcgagc gcgtcctcgg 8941 tgacaggtcg tccctggcat gccttgcgca cgccattgat gaccttggta cggctgaacg 9001 gctcggtgac tccggaccgc ttgatcacca tcagcgagca tgtctccacc gtcgtgaaac 9061 gacgggagca gtcaggacac tggcggcgcc tgcggatcga tgtgccgtcg tcggtcgtac 9121 ggctgtcgac gacacgactg tcggggtgcc tgcagaaggg acagtgcata actccaaccc 9181 tcctcacagc agactcaata gcctcgccag gcctcatggg ccccgcgaag cagccccaag 9241 cataggcgat ctccgagggt ctgaagaccg gggggaccac aacttctggg ctgctgctgc 9301 aatccaacca ctagatgtgg ggattggctc atacatccaa gccgtacgcg cgtgtcgcac 9361 gagcatcggc acgcgccacg ccgtcgcacc ggcgctccac actcatggcc gcacagccgt 9421 atcgctgcga cacataggga gataccgtga gcgccgcacg gaggggacgt gggactcccg 9481 cacagatggg ggtcgattcc cggttgaact gatcccggat ggcagactgg ggcaacaacc 9541 cacgaggtcg taccccggcg gtgaagagta caacaatggg cccttttgcc cgccggtcag 9601 gtcgtcagcc atacaccccg acacgcgatc acgtaagccg attcgcgatt tttcactcga 9661 acgtgtgttt ggcgcaacct ttcgaaagca actaccgttg tgcagcaggg agaccatcga 9721 gaggggccga cgtgaccacc accgcagaca gtgccaccat cactgcccag gaccgctccc 9781 agggccgact cgagccggtg catgcgatga acgaatccat gagtcccgag ggacacaagc 9841 gctccctacc ggggcgacct cccggcatcc gggcggacag ctcgggactc accgaccggc 9901 agcgccgagt gatcgaggtc atcagggatt ccgtgcagcg gcgtggctat ccgccgtcga 9961 tgcgggagat cggccaggcc gtcggcctgt ccagcacatc ctcggtcgca caccagctga 10021 tggcactgga gcgcaagggc ttcctccgcc gcgacccgca ccgtccgcgc gcgtacgagg 10081 tgcgcggctc cgaccaggcc gcctccgtgc agcccacgga caccgccggc aagcccgccg 10141 cgtcgtacgt cccgctggtc ggccgtatcg ccgccggtgg ccccattctc gccgaggagt 10201 ccgtcgagga cgtcttcccc ctcccccggc agctggtcgg tgacggcgag ctgttcgtgc 10261 tgaaggtcgt cggtgactcg atgatcgagg ccgcgatctg cgacggcgac tgggtcacgg 10321 tccggcgcca gccggtcgcc gagaacggcg acatcgtggc cgcgatgctc gacggcgagg 10381 ccaccgtgaa gcgcttcaag cgcgaggacg gccacgtctg gctccttccg cacaacgcgg 10441 catatgagcc gatcccgggt gacgacgcga ccatcctggg caaggtggtg gcagtgctgc 10501 ggcgcgtgtg acggctgcgg cgggcgacgt ctgaagacat cgccccctga ccgggccccg 10561 ggacccctgc gccggttccg gggccctgtg ctgttccggt ccgcgaagtg cgggaacccg 10621 gcggcaggcg gattttggat cagtttggat cagtggttag cctgtcgcgg gtccgcgaca 10681 ggctaaccac gatcactcgg gctgagcggc ctccgtctgc tgcgccgagg catcgatcgc 10741 ggccagcgac ctccggacct ggttacggtc cgtcgtgtac cagaagtcgg gcagtgacgc 10801 cttcagatag ctcccgtagc gggccgtggc cagccgctga tccagtacgg ccacgacgcc 10861 ccggtccccc gatgcccgta cgaggcgtcc agcaccctgg gccatgagca gcgcggcgtg 10921 ggtggcggcg accgccatga aaccgttgcc gccggcttcc tccacggcct tctggcgggc 10981 gctcatcaga gggtcgtccg ggcgtgggaa cgggatcttg tccatgacga ccagctgaca 11041 gctggggccg gggacatcga cgccctgcca gagcgacagc gtgccgaaca ggcaggtctt 11101 cgggtcggcc gcgaagttct tgatcagctc gccgagcgtc tcctcgccct ggaggaggat 11161 cgggtactcg gggatgcggg agcggagctc ctcggcggcc agctgggcgg ctcgcatcga 11221 ggagaacagg ccgagcgtgc ggccgccggc cgcctggatc agttccgtca gctcgtcgag 11281 catgtccgcg cgatcgccgt cccgcgcggg gcgcgacaga tgcttggcga cgtagaggat 11341 gccttgcttg gggtactcga agggcgagcc gacatccagt cccttccact gcgggatgtc 11401 gtcgccctcc gtcccctccg gcgcgagtcc catggatgcg ccgacgccgt tgaagtcgcc 11461 gcccagcttc agggtcgcgg aggtcaggac gacggagcgg tccgcgaaga gcttctccct 11521 cagcaggccc gacaccgaca tcggggccac ccgcagagac gcaccgaaac ggtcgtgacg 11581 ctcgtaccag acgacgtccc actccgaacc gttggtgatc cgctccgcca cgtcgtgcac 11641 ggtctcgacc gatgccagcg cctgcttgcg taccgcgtcc tcgtcctgca cggacttgtc 11701 gcgcgtcgcg ccgatcgcgg agatgacagt acggcaggcg tcgcgcagcg ccatgagcgc 11761 gtaggcgaga tcctccggga tctcctccag gcgacccggc agcgccagct ccatcagccg 11821 ctcaaagccc tcggcggcgg tctggagctg gtcggcggcc ttctcattga cgagcttcgc 11881 ggcgcggcgc acggcacggt tgacctgacc gggagtgagt tcgccggtgg cgactccggt 11941 gacccgcgag accagctcgt gcgcctcgtc gacgatcagg acctcatgct gcggtaggac 12001 cggggcgccc tcgatggcgt cgatcgcgag cagggcgtga ttggtgacga cgacctccgc 12061 gagcttggcc cgctcacggg ccatctccgc gaagcactcc gcgccgtagg cgcacttcga 12121 ggcgccgagg cactcccgcg acgacaccga cacttgcgcc caggcgcggt cggacacacc 12181 gggcgccaga tcatcacggt cgcccgtctc cgtctcgtcc gcccagtcac gcatccgtag 12241 caggtcctgc cccagcttgc tggtgggtgc ggcggcctcg aactggtcga acagtccctc 12301 ctcctcgtcc tgcgggacgc cctcgtgcaa ccggtgcaga cacaggtagt tcgacctgcc 12361 cttgagcatc gcgaactcgg ggcgacggcg cagcagcgga tgcagcgcat ccacggtgcg 12421 cggcaggtcc cgctccacca gctggcgctg aagggccagg gtggccgtcg ccacgacgac 12481 gcgctcccca tgcgcgagcg cgggcacgag gtagcccagt gacttaccgg tgccggtgcc 12541 ggcctggacc agcagatgag agctgccgtc gatcgcttcg gcgacggatt cggccatcgt 12601 cacctggccg gggcgctccg tgccgccaac ggcagtgacg gcagcatgca ggagttcggg 12661 gagtgagggc tttgtcatag cgcgaccacc ctacggcccg gcactgacaa tcgggccacg 12721 ccggtgggga cgggggccgg atcaggactg ggagctcttc acgtggggat cggggcgctt 12781 cgggtggaca tgggatccgt tcggttgaga tcagggacaa ggcgacgtga ggtcgagggg 12841 agggccgatt gtgaccgatg tgggccggcg gtggtccatg gatgggtcta ggcgtggggt 12901 cgggggtgag gtggggcgga ggcgccattg cccctcactt gcacgatacg aaccgcgcga 12961 tccctcgatc gcggcagaga tcgactcgac cggaattcgg ttcgccggag gtgggaaccg 13021 gatcggcgcg agcggtgtac caaaagtgat gatgccgcga cgcggcgtca cagcaggtgt 13081 cgcaggctcc tgtctttgat catgagggcc gcccgcttta cgggcagctc gatctcgacg 13141 gagaagcgga agcctgcggt caggaaagca gccacggagg gggtgttgcg aatgtcgggt 13201 tcggcgacga tacgagcgca ggcgggccgg ttgtcgaggg cgaggtcggc gacggctcgg 13261 agcagggttc caccgagtcc tcgcccacgg tcaccgaggc ccccgataag gagatggact 13321 ccaatgtcat ggggccgagc cgggtagtgg cgagccagcg ggtcgaggtc ggcccggtag 13381 atctcccagt aactcatcgg cgtgccctcc agcaggccca tacaggggac gctgcgtcca 13441 tccccgtgga gctgggagtg caggtgctcc tcggtcgcgt tctgggatcc ggcgaggccc 13501 cagaaagcag tgacggcggg gtcgttcatc caacggctga tgatcgaaag gtctctttcg 13561 atccgcacgg ggacaaggtg cagcacgccg gccgacgtgc tgaccggtcc ccagtcggcg 13621 acttcgccga gcagatcggt gtccttcggg acggcggagg caggcacgcc gatgccggtg 13681 ttcaggcttc gctccgcgcc gatgccggtg tcctcggcac cggcatgctc cgcaccggac 13741 gacgccgtgc cggaaggctc cgtgccgatg tcgttcgcga agaaggcgcg gaattcgtcg 13801 ggcaggcgca ggtccagcgt gtcctcgatg tctgcgcccg cgtcggctgc cgggtgccgc 13861 gcagcgtggc cgcggtcctc gcgagcactc gggctcgtct tgatgccgat ctcggtgccc 13921 ggggcgaaac ctgcgttggc agtcgcgtcg gtgggaggca cggggacgct cctctcagga 13981 ggcggggtga gtcatgttcc tcaggaatga agggggttgg cgatggtgac gtagacggac 14041 tgggtgtcga cggggccgac gagttcgtcg aggccgtgca gccgggtcag gaggttggcc 14101 ttgcagcgca ggaccggtga gtcgagcaga tgggcaggca gtgatgtgcg tagccgggcg 14161 ggaccggagg ccacttcgcc gaggaagcgg cggaaggcgg cgagcagcag ttgttcgtcg 14221 gcgagatgct gggagccgaa ggcaccgatg agaccaagca cgttgttgat cgcgaggtaa 14281 tacgcgaagc gctcgtcggt gacctcgtcc gagacgaagg tgtcgctgcg ctcgccgatg 14341 ccgtggagcc gcgtgtcgag ttctgcgcgc cgggactcgc ggaagtagta gccctggttg 14401 tcccggtacc ggccgcctgc gggccagccg tcgctgtcca gcagaagcag cgtgttctgc 14461 tggtgcgcct ccagggcgac tccggcctcg gcatccagcc acagcactgg gcgaacgacg 14521 tgttcgaggt agcgcaggaa ccactcggcg gcaacggccc ctcgtgatcg tcccgtgcgg 14581 gctgcgagat gggtgaccag ctcggccagg cgggaccgca agggctcccg gtccgagcgg 14641 gggcgggccg tagacgtgcc ggattgcggg acgtgcggga gaggtgagac gaggccggcc 14701 acacacgaca cgtcgtcggt gggccggaag gggttgtgcc ggatcatcac gtcgagaccg 14761 ggcacagggt caccgtcgag cccatcgacg gcgagccagg cagggtcgcg aacgatgtcg 14821 aatgccgggt gcgcggcctg ccaatgcgtc gagagaccac tgcgcaggag tcggtggacc 14881 tccactccgc gatgcagctc tttgcggagg ttctcacgac gggagttggt gatgcgcagg 14941 cccaacgaca gcttgagcat ggcaggggcc tgggacctgt ggacggtacg tacggaggag 15001 gtgggatgcc atggggcgcc gtgggcactg aggtcgacca gcagtccggc gtcgaggaga 15061 gatgcgactt ctggacggtg ccggatctca cgtagctgcc aagggtgtag gggcaaggct 15121 gcgtagctgc cgggcagcgg gaggtcgggg ccggcgagtc gggccgtgag ctggggcgcg 15181 gggatgacac ggccgcgttc ggtccatgcc gagtcggtgg cgagaaggga gggagcgaca 15241 gccagccagt gcagagggaa gcagccgcgc aactcgggtg agtacagcca tgcttcggcc 15301 tcggagagac cctcgcgact cttcggtgtg gggtggagcg ggtgtccgag gaggagtgcc 15361 tgctcggctg tgaggaagag gtcggggccg tcggccgcct tctctcgccg ctccctgatg 15421 aacgtggcgg ttcgctgggc ggagtcggcg acgcgggcga cgagctcggt ggcggccgac 15481 atgacgggac tggtgacgga tgtgggcttt ggcgcggagg aggtctcgga tccagcggaa 15541 gtcctggact cgccatcatg cgccgaggcg gaaggagcag gagcggcatc ggaggtgagg 15601 atggcggtgg gcgtgagggc ggaggtggcg tcgccaccgg gaggcgccga gcgcgaggtc 15661 gcctctcgtg tgagtagtgc ggcgagggtg acggcgtcga tgggcggggg ctcgtccggg 15721 gcggcggcca ggcgcgggag gccgaagcgg tgccagcccg tgggtgacca gtagtggacc 15781 gggaccagca gggtcgtgcc agtggcgggc agcggaatac ggaggatccc gttgcggagt 15841 gacgtgacgc ctgtctcgcg tacccagcag cggagcaggt tctccacggc tgcggcgtgg 15901 gctgcggtgt gcgggtccgg gtgttccagc aggtcggagg tgaggccgtg caggcgctca 15961 agggccgggg ctccggcctg ggtcggtgtg cggaccggta cctgtgcggt cgtcggcggc 16021 tcctcctggg ggaggcgtgc gacggaggag tcgcgctgca ggaggtgcgg atgaatgtcg 16081 gggcggccgt ccgtggtggg ggtgctgttc aaggctggtc ctcttggcgt ggttctggct 16141 cgtgcggcga cggcggccgt atcgcggtga gggggatggg ttggagtggg ccgcgttccg 16201 aaggtgcgct tggagggggt gtgtcagttg gaggcgaggt gtcgaggggg cttgatggtt 16261 cggttggggg tgagcggttg ctcggggagg cgtcggctga cgggtgacga tccgaaggac 16321 ggggtctgcg tgcacgccgg cgcgcctgcg tcgactgccg ggctatcgcg cccgctcggc 16381 acgatcggcg cggtcggcac tctcgtcgtg gtctgcgcga tcagcgctct catcgcgatc 16441 ggcgcggtca gcgctgtcgt cgagatcagc gctcccgtcg agatcgccgt gctcaccgtg 16501 cccgccatgc tcggcacgat ccgcgcggtc gctgtgccgg gcctgccccg ggtgcggaag 16561 gtgcagccgg ccgtggctcc ggtcgggccc ggtcttgccg cgggacaccg cgtccaccgc 16621 gtcggcaagt cgatcgagca ccgcggacgc ctgctcgtcg ctgatggtca ggggcggaag 16681 gaggcgtacg acactggagt gacggccgcc gagttcgacg atcaggccac gtcgcaggca 16741 ctcgcgctgg atggctgccg cgagttcggg tgcggctggg cgaggggagc gtgccgggtc 16801 cctctgcacc gccgctgccg tccccgcccc tccgccggcg cgggcgaggc ccatcggcgg 16861 actcccagcg ctccgggtcg gatcgagtgc cccgggcgct ccgactccgg ctccaggcca 16921 acccggttcc agcgaggccc ccggcgccga ctggtcagca gctcctccgt gccggcccga 16981 agcggtgagc ccatcgaacc cctcctcggg cgcccagacc gccgactgct tctcatcccg 17041 ctcaggttcg gcctccggct ccaccacctc gaccccgatc atcaaccccc tcccccgcac 17101 atccccgatg caggcgtact cccccgcgag tccctgaagt tggtggagca tccgcgagcc 17161 cagttcggcc gcgcgctcgg cgaggcggtt ctctcggacg taggcgagcg tggccgtgcc 17221 ggcggccatg gcgagttggt tgccgcggaa ggtgcctgcg tgggctccgg gttgccaggc 17281 gtcgaggtcg tcgcggtaga cgatgacggc aagaggcagg ctgcccccga tggccttgga 17341 gaggaccatg acatcgggtg tgacgccact gtgctccacg gcccagaagg atccggtacg 17401 cccgactcct gtctggacct cgtcggcgat caaggggatg gagcggtcgg ccgtgatctg 17461 ccgcatacgc cgcagccacc cgtccggcgc ggggatcact ccgccctcgc cctggacggg 17521 ttcgagaatc atcccggccg ggcgccggac gcccgacttg gggtcgtcga ggacggactc 17581 ggtccagcgg gctgcgagtt cggcgccgcg ttcgccgccg atgccgaagg ggcagcggta 17641 gtcctgcggg taggggaggc gcgcgacccg tacgtcgaag gcgcccccgg aggcttcgag 17701 cgctccggcg gtcatgccgt ggtaggcgcc gctgaaggcg aggattccgg tgcggccggt 17761 cgcggctcgg acgagcttga aggcggcttc caccgcgtcg gtgccggccg gtccgcagaa 17821 ctgcacccgg gcgttgtcgg cgagaccggg cggcagggtg cggaacagct cggtgatgaa 17881 gtcgtccttg acgggtgtcg ccaggtcgag gacatgcagg ggggcaccgg agtcgaggac 17941 cccgcggatg gcctccagga ccacgggatg gttgtgtccg agcgccaacg ttcctgcacc 18001 ggagaggcag tccagatagc ggctgccgtc cgcaccctcg atggtcagcc ctcgtgctcg 18061 caccggcacg atcggcaggg cacgtgcgta ggtgcgcgcc gccgactcgc gcgccgactg 18121 acggcgaagg atgccctcgt gtacggcacc cacccccgcc gactcggaca tacccccgcg 18181 cacagattcg gtcacggcca tggctccctg tcctcccgct gtccaggggc gagcaggtct 18241 ctcgcatcct cgcccgaccc gacatacgaa gccccgcgag cgtccactcg aaactccggg 18301 gaactgggca cgggggaccg cacacgggtg gcggaccccc acggctacca accgtggacc 18361 gttcgcccgg ttacgggttg cttcaagatc cttgccgaga caaaaccgtc gcgggcgcgg 18421 ccacgacccg aggtgcggat gtggccgagg aacacggtgt cgtggaggcc ggtacgccac 18481 gggacggcgc cgctgcgagg gccgttcgca ggacctgttc ggcgcccggc cctcaccccg 18541 gacgcgagct gtcgccttcg tcgcacctgg cggcagccaa tacctggacg cccgaggagg 18601 gcaggcccac gtacacggca ctacggccac gtccctgcgc ctcggtgagg ccgccccgac 18661 ggtcggcacg tcgacgtgtc ccagatcccg gaccgaccca gaaagctcga gttcccgacc 18721 acggtcagcg cacccagtcg gcagaaatag ggaggtgcgc taagtttccg ccgtgaagcg 18781 acatgtggtg gccgtggctg tggcggatgg tgccccgacg ctcgaactgg cggttccctg 18841 cgaggtgttc ggtatcgatc gcagtgatct ggtcgacccc tggtacgagt tgcggttgtg 18901 tgccgcacag ccggggccgc tgcgtacggc ggcggggctc atcgtgccca cctcggacgg 18961 gctggaccga ctgggcgagg ccgacaccgt ggtcgtggcc gcgtgttccc gggccgtaca 19021 gctcgatccc tccgccgacc tgctggaagc cgtgcgccgg gctcatgagc tgggtcgtcg 19081 catcgtctcc atctgctccg gcgcgtatgt gctggccgcg gcggggctgc tggacgggcg 19141 gcgggccacg gcgcactgga tgagcgcgat ggacttcacg catcggttcc ccgacgtcga 19201 cttcgacccg gcctccctct atatccagga cggcacgatc ctcacctcgg ccggcacggg 19261 atccgccatc gatctctgtc tccatctggt ccggcaggac cacggctcgg cggtggccaa 19321 cgaggtggcc cggcgtatgg tcgtcccacc tcaccgtgag ggcggacagg cccagtacgc 19381 gcggccgccg gtccgggtgc gcaaggcgag cgacaccctg gcgccggttc tggaatgggc 19441 ccgccgccat ctgcacgagc agttgacggt gcctcaattg gcgcgggagg cggggttgag 19501 cgagcgcacg ttcgcccgcc ggttccgcga gacgttcggt acgacgccgc tgcagtggat 19561 cctgcaggaa cgcgtccggc tcgctcagga gttgctggag acgacggacg acgccgtcga 19621 gagcgtggcg cagcgcaccg ggttcggtgg cgccaccaac cttcggtacc acttcggtcg 19681 gctcaccggg gtgtcgccgc agacataccg tcacgtcttc cgccatcgca cggcacaaca 19741 gcggcgcgcg ggctgggcag aagagatgcc gtcggagagg tgagatcggc ggtgttccgg 19801 acaagttgcc agctcaggca gcccgtagcg aaaccgttgc cgttctgtcg gtgctccccc 19861 acagcgagcg catagtgtgt ggtgccgtcc aactcgctgc gccgacgcac cctgacagcc 19921 cgcatgacca gcaggtgatc aagaagagtc atcagcggaa agtcatggcc gccgcagcgc 19981 caagtaccgt cactccaggg ggagtcagat catgcgatcg atacggccgt cgttcaccgc 20041 ccgccgaggg aggagcgcgc gccgcagatt ctccccggtg cccctggtcg cgctcaccgc 20101 ggcgctggcc ctcaccgtca ccgcctgtga atcgggcgac gccgaagcag gtgccgacgc 20161 cggcgcctcc gccgcggcgg ggggtgaagg aaagatcacg atcccggacg acatcaagga 20221 ccagctcaag gagcacggga tcgacatcga caagtggaag gacggcgcct ggaagaactg 20281 ggaccgggac gactggctgc gcgaggccaa ggactacatc aacccgatca tcgagggcct 20341 gtgggacccg gatcgcatgc gtgacgccga ggacccggac cggggcgtcg acgacagcga 20401 cctcgccggt gaccagggag tgaccgatcc gacgccgcaa ccggtggacg cgcaggccgt 20461 gtcgcccgcg taccacgcca acgcccccga ggcgggcaag gtgttcttcg actcccccga 20521 gggcacgatg gtgtgctcgg cgacggtcgt gaaggacccg gcccaccccg gtaagtccaa 20581 catggtgtgg acggcaggtc acagtgtgca cgccggcaag agcggcggct ggtaccgcaa 20641 catcgcgttc gtgccgtcgt acaacgacaa ggccatgagc gcggacgcga tgaagggcgc 20701 caccaaggag caggccgccc cgtacggcgt ctggtgggcg gagtgggcgc agacctccga 20761 ccagtggatc gcacagggcg gcccgacggg cggggacggc gcgtcgtacg acttcgcggt 20821 gctgcatgtg aagccggagg cgggcggcaa cggcaagtcg ctggaggaga cggtcggttc 20881 ggcccttccc gtggacttca acgccccggc cgttcccgac gtggacagca tcaaggcgat 20941 cggctacccg gccgccgcgc cgttcgacgg ccagaagctg taccagtgcc aggaccagcc 21001 gggccgtctg tcgctcaaga cctccgatcc gaccatgtac cgcatcggtt gcactatgac 21061 cggcggttcg tccggtggcg gctggatcgc ggcgggttcg gacggcaagc ccgcgcttgt 21121 gtccaacacc tcgatcgggc cggtggacgc cggctggctg gccgggccgc ggctcggcaa 21181 ggaggccaag acgatcttcg acggggtgag cgagaagttc gccggtcagt gacgatcgcc 21241 gaagcccaag ggtgacggcg ccgcgcggcg gtgggacggt ggggagaaac cttcaccgcc 21301 tcaccgccgt tcgctctcaa ctccacgggc atagtggggt gtcgcgttca agggccgcgc 21361 aggtgcccgc acttggcagg ccccgccgcg actcgagaaa gacacgcgca cggcagcatc 21421 acgcttcaac gggggttacc gcaccatgcg ttccacatcc acgcccgaaa ctccacgccg 21481 ccgacggcat tccgccctcg ccgccaccgg actgctcgcc gcactggcgc tgaccgcgac 21541 cgcctgctcg gccgaggagg cgagcgaccg ggccgacgcc gccgcgtcgc aggccgccga 21601 cgccgcgggt gacggcaaga tcgagattcc cgccgagctc gcggacaagc tcaaagagca 21661 cggcatcgac atcgacgagt ggaaggacgg cgcctggaag gactgggaca aggacaagtg 21721 gctcagcgag gccaaggact tcgtcaaccc ggtcatcgag ggcctgtgga agcctgaccg 21781 gatgcagtcc gcgaaggagg ccaacaagac gatcaccacc caggacgccg ccgcggacca 21841 gggcgtgagc gatccggaac cggccctcgt ccaggcgacg gccgagaaga cgccgtacca 21901 ccagaacgcg gccccggtcg gcaaggtctt cttcgacacc cccgacggcc cggccgtctg 21961 ctccggcacg gtcgtcaagg acgtcaacca ccccggcaag tccaacctcg tctggacggc 22021 cggtcactgt gtgcacgccg gtcagggcgg tggctggtac cggaacatcg ccttcgtccc 22081 ggcgtacaac gacctcggca agtccgaggc ggagctgggc agtgcgacga acgcggagat 22141 cgccccctac ggcaactggt gggccgactg ggtctcgacc tccaacgagt ggatccaggg 22201 cggctcggag acgggcggcg acggcgccgc gtacgactac gccgtcctgc atgtgaagcc 22261 ggagtcaggc gcgaagtccc ttgaggagac gaccggcgcc ctggacgtcg acttcaccgc 22321 cccgtccgcg accgaggtcg acacgatggg tgcctggggc tacccggcgg caccgccgtt 22381 caacggcctg cagatgtaca agtgcctcga ccgtccgggc cgtctctcgc tcagcccggc 22441 cctgccgacg atgtaccgca tcggctgcac gatgaccggc ggttcctcgg gcggcggctg 22501 gttccgcgtc gtgaacggca ggaccacgct ggtctcgaac acctcgatcg gcccggagga 22561 ccacacttgg ctcgcgggcc cgcagctggg caccggggcg gagtcgctgt accagaacat 22621 gagcaagacg tacggcggcc ggtgaccgcc ggcccctgac agccgccgcc tgacctgccg 22681 gcacacacga aggcccgcct cctacgacag gagacgggcc ttcggcgttg ctacgacgac 22741 tcaggcggtc ggcgtcggaa cgtacggcgc gagatccgcc gccagctcct catgcacccg 22801 caccttgagc agcgtgccct ccggggtgtg ctcctcggag atcacctcgc cctcggtgtg 22861 ggcgcgggcg accagcttgc cgtgtgtgta cggcaccagg gcctcgatct cgacggacgg 22921 cctgggcagc tcgttgtcga tgagggcgag cagttcctgg atgccctggc cggtgcgggc 22981 cgagacggcg atggagcgct tctcgatccg catgagccgc tgaagggtca gcgggtcggc 23041 cgcgtccgcc ttgttgatca cgacgatctc gggtacgtcg atcgcgccga cgtccctgat 23101 cacctcgcgc acggcggcca gctgctcctc cggggcggga tgcgacccgt ccaccacgtg 23161 caggatcaga tcggactcgc cgacttcctc catggtggag cggaacgcct cgaccaggtg 23221 gtgcggcaga tgccgtacga agccgaccgt gtcggccagc gtgtacagcc gtccgctcgg 23281 ggtctcggcc cggcgcacgg tcgggtcgag ggtcgcgaac agggcgttct cgacgagtac 23341 gcccgcgccc gtgaggcggt tgagcaggga ggacttgccg gcgttggtgt agcccgcgat 23401 ggcgaccgag ggcaccttgt tgcgccggcg gacctggcgc tggatgtcgc ggccggtctt 23461 catctccgcg atctcccggc gcatcttcgc catcttctcg cggatccgtc gccggtccgt 23521 ctcgatcttg gtctcaccgg ggccacgggt ggcgaggccg ccgcccttgc cgccgcccat 23581 ctgccgggac agcgactgac cccagcctcg cagcctcggc agcatgtact gcatctgcgc 23641 gagcgcgacc tgcgccttgc cctctcggga cttggcgtgc tgggcgaaga tgtcgaggat 23701 cagggccgta cggtcgatga ccttgacctt gacgacgtcc tcgaggtgga tgagctggcc 23761 cgggctgagc tcaccgtcgc agatgacggt gtccgcgccc gtctcgagga cgatgtcgcg 23821 tagctcactg gccttgccgg agccgatgta ggtggccgcg tcgggcttgt cgcggcgctg 23881 gatcacgccg tcgagcacga gcgcgcccgc ggtctccgcg agggcggcca gctccgcgag 23941 ggagttctcc gagtcctgcg cggtccccga ggtccagaca ccgacgagca cgacgcgctc 24001 caggcggagc tggcggtact cgacctcggt gacgtcctcg agctcggtgg agagacccac 24061 gacacggcgc agggccgcgc ggtcggagcg gtcgaactgg tcgccgtccc ggtctccgtc 24121 gatctcgtgg ctccaggcga cgtcctcttc catcagggca tcggcccgac gaccttcggc 24181 gtgggtgtgc gcgaaacgct ggttgtcctg ggaaaaggat gaagaggagg tcattgggtc 24241 cttacgtcga tcgggaatct gatgcgtcac tcatcacaac gcgcgagcgc cccgggagat 24301 tcccgcgggc cgtgccgcgc cgacccgaaa atggtcgcac ggcacggccc gtctcgtcac 24361 cgccttattt cgcggccgtc ctaccagccg tcttgccggc cgtcttgccg gtggtcttgc 24421 cggccggctt cttgaccggc ttcgtggccg gcttcttgac ggccttcgtg ggatccaacg 24481 acttccactc cgggtggccc ggcatcggcg gggtcttctt gccgtacagc caggcgtgca 24541 ggaacccgtc gaggtcgcgt cccgagacct cctccgccag cgcgacgaag tccgcggtgg 24601 aggcgacgcc gtcttggtgg cggctcaccc agaggcgctc cagacgctcg aaggcctggc 24661 gtccgatctc ctgccgcagg gcgtacagga tcagggcggc accgtcgtag acgttcggcc 24721 ggaagatccc gttcttcttg ccggcggccg gcgccttggg tgccgcgggc ggcccgcctg 24781 ccgcgcgcca gcgatcggag gcggagtacg cggccttcat ccgcgcctcc atcggccggt 24841 cggcggtctc cgccgcgtac agggcctcgt accaggtggc atgtccctcg ctgagccaca 24901 ggtcggacca ggtgcgcggg ctgacgctgt cgccgaacca ctggtgcgcc agttcgtgca 24961 ccatgatcga ctcgacgtac cacttcggga aggcggtctg ggtgaaaagc tccctctcga 25021 acagcgacag ggtctgcgtc tcgagttcga agccggtcga ggcgtgcgcc atgagcagcc 25081 cgtacgtctc gaaggggtac cgcccgacct tcttctccat ccaggcgagg tgaccgggcg 25141 tcttcttcag ccacggttcg agccgctcgc ggtcctcgcg ggccacgacg tcccgcaccg 25201 gcagcccgtg cgggcccttg cggtgcacca cctcggagcg gccgatggac acctgggcga 25261 gctcggtggc catgggatgc cgggtccggt acgtccatgt cgtcgagcgg cccgcgcggt 25321 ccacgcccgt cgggagtccg ttggcgacgg cggtgtagcc gttgggcgcg gtgacccgga 25381 tggtgaacag cgccttgtcg gaggggtggt cgttgcacgg gaacacgaca tgcgcggcgt 25441 cggcctggtt ggccatggcc agcccgtccg tggtccgtac ccagccgcct tcccgcttct 25501 cgccgtagac ggggtcgctg gtgtgccgca cggtaatccg cgtccaggtg ccttcgggca 25561 gcgcctccga gggcgtgacc actaggtcct caccggcact gctgaacgcg gcgggctccc 25621 cgtcgaccac gacggactcg accttgccgt gcgcgaagtc caggttgacg cggtccaggt 25681 cctcggtggt ccaggcgtca atggtggtga cggcctggag gggcttgtcg ttcttgccgg 25741 gataggtgaa ggacagatcg tacgacgcca cgtcgtagcc cgggttgccc agatgcgggt 25801 agaggcggtc gccgatgccc agcggcgtgg cgggcgcact ggcggcgagg aggcagaggg 25861 agacggcggc ggagaccatc gcgggcaccc tcaggcgccg gctgggacga ggcgcacgcc 25921 gaacctcgtt acggggggtg aggagcatgc cccacggcta tcagcacaca gtcacaggac 25981 gtcgacgacg cgcgcccgac ccacccgaac gagtgggcac ccgcgacacc ctgacggagc 26041 gtgcgccgac agcccgcatt aactccgcgc tcacgcaccc tgtgtctgcg gctgcgccct 26101 gctcacgtcg tacacgccgc ccacattgcg catggcacgc atgagcccgg gaagcagcgc 26161 cgcatccggg agttggaccg tgtaggtgtg ccgcacgcgc tgctgcgtag gaggctcgac 26221 ggtggccgag acgatttccg cgccttccat ggccatcgct tcggtgaggt ctgccaggag 26281 atgcgggcga acgaacgatt cggcgaccag ggtgacccgg cactcagtgg tgtcccccca 26341 gcgcacatcg acctcggcac gccccccact cttcatgcgc gccaccgcgg cgcatgagac 26401 gcgatgcacg gtcaccactc ccccacgtac ggagaatccg gtgatctcgt cgggcggtac 26461 gggggtacag cacccggcga ggcgcacatt cgccccgggc cggtcggcga ggacgttggc 26521 cgtggaccgg ccgacggcgc cttccgtggc ctgccgcgcg gccgaaccct ccgccgtggg 26581 cccgtccgcc gctccccgga aggccacgcc cggctccttg gcctccgcgc cggcctgtgg 26641 gggatgcgcg gccagccacc gctggatggc gatgcgcgcg gcgggcgtat gggcgtgctc 26701 cagccactcc cgggagggct cggatgccgg gtcctgcccc atcagcagct ggacggtgtc 26761 gccgtcccgc agcacggtgc tgagcgtcgc gaggcgcccg ttgacgcggg ctccgatgca 26821 cgcgtgcgcg tcctccccgt actgcgcata ggcggcgtcc acacaggtcg ccccctcggg 26881 cagccccagg gtgcccccgt cgggccggaa cacggtgatc tcccggtcct gtgcgaggtc 26941 ctcacgcagg gtggaccaga aggtgtccgg atccggcgcc gcctcctgcc agtcgaggag 27001 gcgggacagc cagccgggcc gggtggggtc ggcgcgctcg ccgtccacgg tctgctcctc 27061 gggggacgag gcgtaggggt tgccgagtgc gacgactccg gcctcggcga cacggtgcat 27121 ctgatgggta cggatgagga cttcggcgac ctgtccgtcc gcgcgggcga ccgcggtgtg 27181 cagcgactgg tacaggttga acttggggac ggcgatgaag tccttgaact ccgagacgac 27241 gggcgtcata caggtgtgca gctcgcccag tacgccgtaa cagtcggcgt cctcgttgac 27301 gagcaccagg agccgtccga agtcggagcc ccgcagccgt ccgcgcttgc gggacacccg 27361 gtggaccgag acgaagtgcc ttggccggat gaggacttcg gcctggatgt ccgcctcgcg 27421 cagtacgccg cggacctcgt cggcgatctc cgcgagcggg tcgtccgcgc gggaggcgtt 27481 ctcgacgatc aactcccgtg tgtgctcgta ctcctcgggg tggaggatcg cgaagaccag 27541 gtcctccagc tcggacttga gggcctggac gccgagccgt tcggcgagcg ggatgaggac 27601 gtcacgggtc accttggcga tccgggcctg tttctcgggc cgcatcacgc cgagcgtgcg 27661 catgttgtgg agccggtcgg cgagtttgat cgacatcaca cgcacgtcgt tgccggtggc 27721 gacgagcatc ttgcggaagg tctcgggctc ggcggcggcg ccgtagtcga ccttctccag 27781 tttggtgacg ccgtccacga ggaagcgcac ttcctcgccg aactgctccc tgacctgatc 27841 gagcgtcaca tcggtgtcct cgacggtgtc gtggagcaga gaggccgtca aggtcgtggt 27901 ctcggcgccg agttcggcga ggatgagggt caccgcgagg gggtgggtga tgtacggctc 27961 gccgctcttg cgcatctggc cgcggtgcga ggactcggcc aggacatagg cgcggcgcag 28021 cggttcgagg tcggcgtcgg ggtggtgggc ccggtgggcg tcgacgacat ggccgatcgc 28081 gtcgggcagc cctcggcgtg gggcggggcc gagcagcgcc gcccggccga ggcggcgcag 28141 gtcgatgcgt gcgcgggcct tcctgcgcgg cacggcagcc ggcacggggc ccgctaccgg 28201 gcctggcgtc gcggaattcg tggcctccgc actcatgggc acctccggct gcgtaaccgg 28261 cggacggggt accccatggc ggacacggct caggggatgg cggcttgtcc cccgtccggg 28321 ccggtgcttg atgctaccga gcccatcacg tgtggctgac cgcctccggc cgagcgtgaa 28381 acggatcacc cattcgagcg agggtttgca ggtttacggt tttgcgccat gcgaccagcg 28441 gctgttcgca ctttccaacg ccgacggggc gtcagaaccc ctactcccca agctcaggcg 28501 cctcatgacc ccgcatcccg gccacggtcc gctcagcggg cgatcgtttc cagccagtcc 28561 gcgtcgatct cgccctcggc cacgatcacc gcgggaccgg tcatctcgat ctcaccgtcg 28621 ggccgctcgg tgatcacgag tgtgccgccg ggcacatcga cggtgtacgt cgcgggggca 28681 ccggtgagcg ccgggtcggc accgtcgcgg cgcgcggcgg ccacggcgac ggcgcacgcg 28741 ccggtcccgc acgaccgggt ctcgcccgcc ccgcgctcgt gcacgcgcag ggcgacatga 28801 cggggcccgc ggtcgaccac gaactcgaca ttgaccccgt ccgggtagac ggaggccggg 28861 ctgaacggtg gcggggagta cagattgccg gcgtgcgcga ggtcgtccac gaaggcgacc 28921 gcgtgcgggt tgcccatgtt cacgttccgc gcgggccagc tgcgctcacc gacgctgacc 28981 gtgacgtcgc cctcggggag gcgggccctg cccatgccga cggtgacgtc accgtccttg 29041 tcgatgtgga cggtcttcac tccgccgcgc gtggcgacgg ccagatcacc ctcggtgaca 29101 tgcccggcgt gctggaggta gcgcgcgaag acccgtacgc cgttgccgca catctcggcg 29161 atggagccgt cgccgttgcg gtagtccatg aaccactcgg cgtcggccgc catgtcctgg 29221 gcctcggggt gcgccgcgga ccgtacgacg tgcagcaggc cgtcaccgcc gatgcccgcg 29281 cggcggtcgc acagggcggc gacggtggcc gggggcaggt cgatggcgtt ctccgggtcc 29341 gggacgatca cgaagtcgtt ctcagtgccg tgacccttga ggaaggcgat ccgcgtgctc 29401 attcctcgat cgtacggtgc cgctacgaca gagcggaaag agcgccttca gcgcagacgg 29461 gccactcgcc acacggccag gacgacgatc gcggcgacga ccaggacgta agcgatcacg 29521 acccgccagt ccaggcggcg ctcggagccc cgctgcggca gcccgggcca cgtgtaaccg 29581 actcggcggg cggccatcat gccccagccg gcggcgcagg agcagatgag gagccccagc 29641 atggcgatca cggcgccgct gtcgccgaag tcgaaggcca gcgggaaggc gaacatcagg 29701 gagccgacgg ctgccaggcc gacgatgggc gcgagctgcc agatgcgcag tcggcgctgc 29761 gggcgcagct cgacctcgac ctcggggccg gagtcgtaca tctcctccgg ctcgggaccg 29821 tcgtcggtga cgccgccctc ggtctcgtcg agcgcgtcgg gaatcggacg gtcgccttcc 29881 ggcttccgct cacccgtgtc agtggtgacg tgctcggtgc cttgtgcggt gtcgcgaggg 29941 ccggcctcca tcgccacgcg ccctcccaac tcggactcca cttggtcgat cgaagctcga 30001 tgatggcatg gcgccggagg ccgggatgac ggccggagcg tcccgatgcc atcacgtgat 30061 caggctgtaa ccggtcgttc gaccaacgcc agtgcgagat gcggaagttc tg //