LOCUS       NZ_BNBM01000018        22341 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence18, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000018
VERSION     NZ_BNBM01000018.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 230539)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 144128
            Orig. end                         :: 166469
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22341
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22341
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22341
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12341](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12341)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    40..53
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            43..1521
                     /locus_tag="IE325_RS36235"
                     /old_locus_tag="GCM10018780_73190"
     CDS             43..1521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437201.1"
                     /locus_tag="IE325_RS36235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73190"
                     /product="VCBS repeat-containing protein"
                     /protein_id="WP_190074395.1"
                     /transl_table=11
                     /translation="MHKHQLRLALATATAAALTGGLLGLSAAGTASAADSATVPHADFN
                     GDGRGDVAFSADGAYVDGKKEAGQLVVLYGTATGVSSAKRHTISQNTTGAPGTAEAGDR
                     FGYDTAYADFNGDGYDDIAVGAQGEDAGSDVDGGGLAIFWGSASGITGKGVTVADPAPT
                     AHDRWGKNLAAGDFDGDGKADLAVGSNNTTVYVLKGGFSSSGTPGGRYTVKPPIVGTEL
                     NGPLNLTAGDVNGDKRTDLVIDGYENQTEYGWNRNYYVPGSSTGLSTANIRTIKPGVIT
                     AIGDIDNDGYGDIVSGAAWNATASDGTSVPDSAKGGKVWVTYGTASGPGTATGITQDTG
                     NVPGGSETNDMFGYELDLGDINGDHYLDLAIGVAGEDFGSAVNTGAVTILYGGPNGLNT
                     TSGAQSLAQSTAGVPGNDENNDMFGIDVKLDDVSGDGKADLIAGSAENDGNGGVTYLPS
                     NGSKITTTGSRTIAPSTSGVSTTGSPYFGANFAD"
     gene            1596..3011
                     /locus_tag="IE325_RS36240"
                     /old_locus_tag="GCM10018780_73200"
     CDS             1596..3011
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019055449.1"
                     /locus_tag="IE325_RS36240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73200"
                     /product="VCBS repeat-containing protein"
                     /protein_id="WP_190074396.1"
                     /transl_table=11
                     /translation="MARLPALALATATVAATLTLLTPTPATAAPAKYADDFNGDGYRDL
                     ATAAPYTPVGGKTDAGAVVVNYGSANGISAARRTVITQNTAGIPGTAEQGDKFGRALTS
                     GDLNRDGYADLVVGSTGENAGAGAVVIVWGGKNGLSGGQVVPDPATSAHDEYGMSLTVG
                     DFSGDGKADLAVGSTGSDIWIHKGGFLKASGAASRYKVATDLYTGAIYGSQHLAAGDVN
                     GDAIADLIVSGTQAETYDNGTFVYQGAASGLARKTFIKNGAYELAAVGDLNGDGYADVV
                     TSTYGDDGTTSLGGSLNAYLGSADGLRTRPQTTITQDTPGVPGSDEEGDWFGNALSIAD
                     INRDGYADVAVGTLHETIGTAKIAGSVTVLRGSATGLTATGAQSFTQNTSGVPGTAESA
                     DRFGASVRLSDLTGDGRADLSIGADGENHPAGAIYSLRGAATGVTTTKATSFGPGSLGL
                     PTGYLRLGQVMLG"
     gene            3049..4062
                     /locus_tag="IE325_RS36245"
                     /old_locus_tag="GCM10018780_73210"
     CDS             3049..4062
                     /GO_function="GO:0031267 - small GTPase binding [Evidence
                     IEA]"
                     /GO_process="GO:0006888 - endoplasmic reticulum to Golgi
                     vesicle-mediated transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029158.1"
                     /locus_tag="IE325_RS36245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73210"
                     /product="Yip1 family protein"
                     /protein_id="WP_190074397.1"
                     /transl_table=11
                     /translation="MSQLGSNGGPECRGPARDSPGPGTFEDVAGFRIGRGSRNNGTPQT
                     RPQQPPYGQQAPQGPSYGYPPPPQPGGGGGGGWPQANGGGGHGGYGGHGQQGGHGGHGE
                     PEYFGDDGGYPHNPPHDPYAANNPGHTQAFSVNDDPYNQGGTYQAGAAPAGPIGPRLHW
                     KPLLRGVVLSPTQTYLQMRDYTMWGPALIVTFLYGLLAVFGFDTAREDAINATLSNAVP
                     IVAVTAIAMVVSSFVLGVVTHSLARQLGGDGAWQPTVGLSMLIMSLTDAPRLVCAMFAG
                     GDATFVQILGWATWVAGGALLTLMVSKSHDLPWPKALGASSIQLIALLSIVKLGTF"
     gene            complement(4124..4621)
                     /locus_tag="IE325_RS36250"
                     /old_locus_tag="GCM10018780_73220"
     CDS             complement(4124..4621)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240229.1"
                     /locus_tag="IE325_RS36250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73220"
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_190074398.1"
                     /transl_table=11
                     /translation="MTDNRENLTYERFGVAIRELAQTIADDGFEPDIVLSIARGGVFVA
                     GGLAYALDCKNLHLVNVEFYTGVGTTLEMPVMLAPVPNAIDFTDKKVLIADDVADTGKT
                     LKLVHDFCLDHVAEVRSAVIYEKSHSLVKCEYVWKRTDEWINFPWSVLPPVVRRDGQVL
                     DA"
     gene            complement(4618..5193)
                     /gene="dcd"
                     /locus_tag="IE325_RS36255"
                     /old_locus_tag="GCM10018780_73230"
     CDS             complement(4618..5193)
                     /EC_number="3.5.4.13"
                     /GO_function="GO:0008829 - dCTP deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006229 - dUTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dcd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948066.1"
                     /locus_tag="IE325_RS36255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73230"
                     /product="dCTP deaminase"
                     /protein_id="WP_190074399.1"
                     /transl_table=11
                     /translation="MLLSDKDIRAEIDAGRVRIDPYDQTMVQPSSVDVRLDRYFRVFEN
                     HRYPHIDPSVEQVDLTRLVEPEGDEPFILHPGEFVLASTYEVISLPDDLASRLEGKSSL
                     GRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCMFRLSSPAEFPYG
                     SERYGSRYQGQRGPTASRSFQNFHRTQV"
     tRNA            5717..5790
                     /anticodon=(pos:149877..149879,aa:Gly,seq:ccc)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE325_RS36260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10018780_t00710"
                     /product="tRNA-Gly"
     gene            5717..5790
                     /locus_tag="IE325_RS36260"
                     /old_locus_tag="GCM10018780_t00710"
     misc_feature    5747..5761
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    complement(5826..5841)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.01"
                     /tool="antismash"
     gene            <6108..6316
                     /locus_tag="IE325_RS46340"
                     /old_locus_tag="GCM10018780_73240"
                     /pseudo=""
     CDS             <6108..6316
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009717801.1"
                     /locus_tag="IE325_RS46340"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GCM10018780_73240"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RYILNPPAPPPASTSTSTWARSTSTNSSASCARTASTGRSPPVCS
                     PGRRRRRSLPCSDRGAGRVRALGG"
     gene            complement(<6282..6879)
                     /locus_tag="IE325_RS36265"
                     /pseudo=""
     CDS             complement(<6282..6879)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655394.1"
                     /locus_tag="IE325_RS36265"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPMTLEFSDLLRLLDERSTSFRAAIAAAPDLDVQVPTCPEWTLFD
                     LVQHLGRGTASGPLPSARGPAGLVGRVDAAAAGRAAGGGPGSRLPDVVGYVAVAAERRR
                     RRPAPGPGDRGAHLRRPGRPGCPAAPAGRGGTRRCRRVPVHLRRDDDRLAAQAHGLRLP
                     RHRGPLPAPHRRRKRHTVHPPARHPYRRAPGHGQRL"
     gene            7064..8173
                     /locus_tag="IE325_RS36270"
                     /old_locus_tag="GCM10018780_73260"
     CDS             7064..8173
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321121.1"
                     /locus_tag="IE325_RS36270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73260"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_190074400.1"
                     /transl_table=11
                     /translation="MSACRRRTAIAAVLSPAMAVSLVACGQGGESAGSGGTAPGEGGFA
                     IGLLLSQNVQTRWEAFDKPLIEKKIKELCADCATEYANAEGDVATQQQQVETLIDKDVR
                     VLLLSAVNFRSLRSSVERAHDAGIPVVAYDGLVEGPIAAHVSFDNEQVGRVQGEALLKA
                     LGDKAEGGQIVMMNGPQTSPTHLAFEKGARSVLEGKVRIGKTYDTPGWSQETAHTNMDG
                     AIAALGADSIDGVYAANDGLATGVISALKAAGIDPLPPVTGQDADLAAVRRIITGEQYM
                     SVYKPFKAEADAAAEMAVALGRGEKLDRIADTTVDTATTKDIPAVLLDPVPVTVDDIKA
                     TVVEDGVYTTEQICIPEIASACKKAGLTE"
     gene            complement(8196..10004)
                     /locus_tag="IE325_RS36275"
                     /old_locus_tag="GCM10018780_73270"
     CDS             complement(8196..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042082.1"
                     /locus_tag="IE325_RS36275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73270"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190074401.1"
                     /transl_table=11
                     /translation="MKHAQDDPRDHPLHSPTGPTSPGRRRTGPQEVRRVLRGQGRRISL
                     AVALAAAGSALALAQPLVVRRVIEAAGAGLATGGAIGLLVVLFLAQAAVQAVARYVLTR
                     TGEGVVLGLRLDLIAHLLRLPMRTYDRSRTGDLIARTAADSTALRLLVSEGFTDAVTGL
                     VGLVGVVILMVWLDWVLFLIVLAVIAVGSVAVASVLRGIERASLHAQQATGAMTAELER
                     ALGAIRTVRASRAEERETRRIGAEARSAYRQSVRVGAMDAVVAPAITLTINGSFLLVLL
                     IGGIRVAGEDGSVADLAAFLLYMLYLMSPVAAVFQALSTMRQGLGALRRISEVLDLPGE
                     PGPEPERRPARPAHDVPVLEFQDVRFRYEPGRPVLRGVSFTVPRRGHVALIGSSGAGKS
                     TVFALAERFYDPDAGRVLFEGRDIRTLGPAEHRARIGLVEQHAPVLYGTLRENLLYAAP
                     CADPAELDRVVGLAQLSDVVARSPYGLDTPAGEHGMALSGGERQRVALARSLLTHPSLL
                     LLDEPTAHLDALNEAALRRSIRRITHECALLVIAHRYSTIRAADLVVVLDGGRVVATGT
                     HDELLRTSEHYRFLARAQGTGDVLSG"
     gene            complement(10001..10564)
                     /locus_tag="IE325_RS36280"
                     /old_locus_tag="GCM10018780_73280"
     CDS             complement(10001..10564)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="IE325_RS36280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73280"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_190074402.1"
                     /sec_met_domain="PF13471 (E-value: 1e-12, bitscore: 41.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDPAADWEFLLRDPEPDPPPRPPRRARLLAAARTVRAARLLRRR
                     GWPDAQRYLRTLRPACPPRWEPAEAVRLARREVLPCLTWLRLADPDALCLPRSYALVTY
                     LTTLGLPAEVVVARQRSSIGGRFAFHAWAELYDEVLGDIPGLRTGFAVLQRVGSEQVGR
                     AGEESGAGSEAGSPRAMGSPGSAV"
     gene            complement(10561..10845)
                     /locus_tag="IE325_RS36285"
                     /old_locus_tag="GCM10018780_73290"
     CDS             complement(10561..10845)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="IE325_RS36285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73290"
                     /product="PqqD family protein"
                     /protein_id="WP_190074403.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.4e-10,
                     bitscore: 34.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLLRLTEQTAFDPADGTGVLLDGAEGAYYELNPVATLMLQAALR
                     YDTTEEAVRHLGERIDATDTMLRDGLATLTGRLTENHLAEPGTDPTAAP"
     aSDomain        complement(10591..10830)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE325_RS36285_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.80E-11"
                     /identifier="RREFam002.1"
                     /label="IE325_RS36285"
                     /locus_tag="IE325_RS36285"
                     /protein_end="85"
                     /protein_start="5"
                     /score="34.9"
                     /tool="antismash"
                     /translation="LTEQTAFDPADGTGVLLDGAEGAYYELNPVATLMLQAALRYDTTE
                     EAVRHLGERIDATDTMLRDGLATLTGRLTENHLAE"
     gene            complement(10851..12341)
                     /locus_tag="IE325_RS36290"
                     /old_locus_tag="GCM10018780_73300"
     CDS             complement(10851..12341)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="IE325_RS36290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73300"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_190074404.1"
                     /sec_met_domain="Asn_synthase (E-value: 7.9e-18, bitscore:
                     58.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDATADAHFRTVAGILRTLPAELSGCVVTPERILVFRGLSSPDQ
                     IFHRRTGTRISWSSDPRDLFDGRLPDLDREKLWRSCRGEDVLLYPGLGLLRPGQFTAFG
                     PRATRTETYERAVPLDLPHRTTLRDYARLTHDLLLEETRPCTGGRIGILLSGGVDSALV
                     LAALTEHGADVTAYHMGTDDPAADESGFARQVCRRLAVPLVTVPRVTDDDYFSTTCDFS
                     HPFNHVWPRSLERVADRIAADGVRVVLSGLEGDTLFGPLRYGLYDILAGEVPAYEKWRM
                     LRGLLGTRWELSRILRSARPSYSLYADPQALAEVELGSDFLVPVQGAAPEPYDLDFAPQ
                     EHTLNLALWRPRGIHLAKPLGGRSLRRLAAGLPDAYRLIPHAGRTIDKPVLRLAAADLL
                     PPDIWRHYGRTWLGSPDETWCLSHPGALARILGDPDARLTALGVVDPRRLDEVLGDPGA
                     LRRNAENLLCSAMVELFLRDLEAHLSRRPRTSAADDRR"
     misc_feature    12386..12397
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(12457..12468)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.49"
                     /tool="antismash"
     misc_feature    complement(12805..12819)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            complement(13140..13835)
                     /locus_tag="IE325_RS36295"
                     /old_locus_tag="GCM10018780_73310"
     CDS             complement(13140..13835)
                     /GO_function="GO:0019172 - glyoxalase III activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986195.1"
                     /locus_tag="IE325_RS36295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73310"
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_190074405.1"
                     /transl_table=11
                     /translation="MSKILFVLTGADHWTLADGTKHPTGYWAEELVAPYEAFTAAGHEI
                     VVTTPGGVVPPLDQGSLAPQFNGGEEGAKKIADTIASISEIQHPLRLEDVDLDDYAAVF
                     YPGGHGPMEDLAVDATSGRLLVNALTSGKPLGVVCHAPAALLAATEADGGNAFAGYRLT
                     GFSNAEEIQSGLAAGAKWLLQDRLVEIGADYQEGEPWAPNVVIDRNLVTGQNPASAGPA
                     AAEMLKKLA"
     gene            complement(13859..14542)
                     /locus_tag="IE325_RS36300"
                     /old_locus_tag="GCM10018780_73320"
     CDS             complement(13859..14542)
                     /GO_function="GO:0019172 - glyoxalase III activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014068.5"
                     /locus_tag="IE325_RS36300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73320"
                     /product="type 1 glutamine amidotransferase
                     domain-containing protein"
                     /protein_id="WP_190074406.1"
                     /transl_table=11
                     /translation="MTNQATYGTSEHRTGLWLGELVHFYDKAVKAGHTVDVVSPAGGEV
                     PLDPRSLGRLFVDRTVRGYLDDQAFMDALKATPSVADTDPDDYSTIFFTGGHGTMWDFP
                     DSADLQRTAQAIYADGGIVSSVCHGACALINLRDTDGNPLVRNRTVTGFATVEERLAGV
                     KSRVPFLLEDELRAKGAKYVRSTVPMTPHAVRDGRLITGQNPVSTKAVSDLILAALAGT
                     EQQPS"
     misc_feature    14721..14736
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 25.67"
                     /tool="antismash"
     gene            14726..15634
                     /locus_tag="IE325_RS36305"
                     /old_locus_tag="GCM10018780_73330"
     CDS             14726..15634
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118274.1"
                     /locus_tag="IE325_RS36305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73330"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_229912266.1"
                     /transl_table=11
                     /translation="MSDHDIHGSGPLDLNLLRTFLAVHRLGSFTAAARRLSLSQSTVTT
                     HIRALERRLGRELFERRAQGVTPLPHADELAARLSAPLDQLAVISGEEPSSTVAPVHLA
                     GPAEFLGTLGLTVLAELVAQGVRLRVATGLTEVLLEELRAGRHDLVVATRRPRGRTLHA
                     ELLGDEEFVLVAAPVWAERLKGQELPTALESLPLIAYAEDLPIARRYWRHVFDRRLHAQ
                     AAITVPDLRSVLTAVTVGAGWSVLPGYLCRTELASGVLRLLHQPEDPPINTSYLVQRPG
                     SSTNPHVTLVREHLLAAAKTW"
     gene            complement(15742..16518)
                     /locus_tag="IE325_RS36310"
                     /old_locus_tag="GCM10018780_73340"
     CDS             complement(15742..16518)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673912.1"
                     /locus_tag="IE325_RS36310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73340"
                     /product="Fpg/Nei family DNA glycosylase"
                     /protein_id="WP_190074408.1"
                     /transl_table=11
                     /translation="MPELPDVEGFRKVLGSCAKGRIIQRVDVRDTGVLHGVSTRRLRDA
                     VEGRRFTEPERHGKWLLARTGGPTLMLHFGMTGELVCCHPDDMVEAHDRVLFTVARDRQ
                     LRYRDQRKLQGLWLADDESEVARLLERQGPDAMAVSRKEFEDVLSARRGSVKTALTDQS
                     VLAGLGNLLADEILWRARLRPTSRASDLAEADCRRLYTHMRRTLRSTVAAGCVPPRDSW
                     LTGHRDDPDPACPRCGHSLRRSRVAGRGTVWCPQCQ"
     gene            16717..17028
                     /locus_tag="IE325_RS36315"
                     /old_locus_tag="GCM10018780_73350"
     CDS             16717..17028
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377827.1"
                     /locus_tag="IE325_RS36315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73350"
                     /product="NIPSNAP family protein"
                     /protein_id="WP_190074409.1"
                     /transl_table=11
                     /translation="MITIHLKYEIDADKLADFEEYGRRWVRLVNRFGGTHHGYFLPSEG
                     DSDIAYALFSFPSLAAYEQYRTDSMSDPECQEAFELARDTRCIKRYERRFLRPLDGVS"
     gene            complement(<17164..17628)
                     /locus_tag="IE325_RS47145"
                     /pseudo=""
     CDS             complement(<17164..17628)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015431.5"
                     /locus_tag="IE325_RS47145"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGVYKAHCGQRQGRGGHQGDAYGGRHERGRHAAIVGAGPRTVRVR
                     KGFVRHQSPEGRRNALLGSDHPQLTVTCLVTDQAQLRELAVYSLVLPPPTTDCGQAILH
                     ACHQVGFTPTTRYITADIAARFTLARAGLATAPLPRTAIDPATPGIRTASI"
     gene            17536..18165
                     /locus_tag="IE325_RS36325"
                     /old_locus_tag="GCM10018780_73360"
     CDS             17536..18165
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006381141.1"
                     /locus_tag="IE325_RS36325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73360"
                     /product="hypothetical protein"
                     /protein_id="WP_229912267.1"
                     /transl_table=11
                     /translation="MTTSLVTTSIRIALVTAAPLALAAVGLVHPHGLSPSTAADWKDLH
                     ILLLPLFPLLTIGLLVPLWHRPRAGIEGAATVAAWAGAFVYAAFYTGLDAVAGIAAGTA
                     VEHAAAGADPGPLKRPLYEVGESLGQVGAYALICAVVCASAALWPRHGARVLPGTAVLL
                     VAGWSFVDSHIFWPRGVWTMCGFALGFALLAWATGSHSRHRPRTAG"
     misc_feature    complement(18168..18181)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
     gene            18581..19795
                     /locus_tag="IE325_RS36330"
                     /old_locus_tag="GCM10018780_73370"
     CDS             18581..19795
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121568.1"
                     /locus_tag="IE325_RS36330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73370"
                     /product="beta-propeller fold lactonase family protein"
                     /protein_id="WP_190074410.1"
                     /transl_table=11
                     /translation="MSTHSSRRGHRGKSRTRRIVIGGGALAVAGAATVAVSLASAGQYS
                     GSAGADHAVFVQGNELDGNTIHVFARGDDGKLEPAGTYDAGGNGGDQVDAPTDSLASQG
                     SLVYDDASGMLLAVNAGSGTVTSFRVEGRTLKDRQVVDSGGEFPSSIAVHGKVAYVMNA
                     GGEGSVQGFRITGKGLKPLHGSHRSLGLDNEDIPRFDTSPGEVEFTPDGRNLVVTTKGN
                     NTVEVFPMKRNGLPSVAEPVVNESAGGVPFAISFDGTGKRMLVAEAEKSTVTTYQVKRD
                     GKLKVLQKPLANGQEVLCWLERAGNFFYGGNTGNSTVSGYRMDKHGKLALTNDVGIATP
                     PSANSQGVIDLAVTEDEKFVYVQNAVSGTVDGFRVERNGSLTKVTTAEGLPAFDESGME
                     GIAAM"
     gene            complement(20358..21494)
                     /locus_tag="IE325_RS36335"
                     /old_locus_tag="GCM10018780_73380"
     CDS             complement(20358..21494)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020135996.1"
                     /locus_tag="IE325_RS36335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73380"
                     /product="sensor histidine kinase"
                     /protein_id="WP_190074469.1"
                     /transl_table=11
                     /translation="MSTGQALWRRLPPWAVDAGLVVLAALDAWINLDDEATPVMWACAA
                     LGSAGLLLRRRFPLAVFLLTLPMLLFMDVGVAPITALYTLAARTRNRPLLAGCALLNAA
                     ASTLAWPLSDTFSDDTFPGDRTWTLIQFVYTLAMAFAPILCGQLVQARHDVARRLVEVQ
                     VAREHERALYAQTVLARERAQLAREMHDVVSHQVSLIAVQAGALQVAAKDPDARDAART
                     IRTLSVNTLDELRHMVTLLRASGGKETELTPQPTLADLQQLIANSGIETALTGGLPPGI
                     STTAQRTVYRTVQEALTNVRKHAPGARAEVRLWHDTQHFGVTVTNTAPTRPSVALPSAR
                     HGLIGLRERAELLGGALIAEPTPHGGYEIELRAPTQPA"
     gene            complement(21494..22159)
                     /locus_tag="IE325_RS36340"
                     /old_locus_tag="GCM10018780_73390"
     CDS             complement(21494..22159)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639785.1"
                     /locus_tag="IE325_RS36340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_73390"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190074470.1"
                     /transl_table=11
                     /translation="MVVDDEALVRSGFELILNASDGIQVVATAEGAQAADAIRREHPDV
                     VLLDIRMPDVDGLTVLREIQTLPEPPTVAMLTTFDTDEYILTALRSGAAGFLLKDTEPE
                     QLAQLVRTLAAGGVVMSPKASRALLRGHPGAGTPQDAGVARVHLLSDRERDVLVLIAEG
                     LSNADIGTRIHLSAGTVKDHVSSILTKLRVSSRVQAALLAERAGLLSDDGADTARSNG"
ORIGIN
        1 ggatgcccgc ccggcatccc cgcatgcagc aggagaaccc gcatgcacaa gcaccagctg
       61 agactcgccc tcgcgacggc caccgcggcc gcgctgacgg gcggtctgct cggcctctcc
      121 gccgccggca cggcgagcgc cgccgactcg gccaccgtcc cgcacgccga cttcaacggc
      181 gacggcaggg gcgacgtggc cttctccgcc gacggcgcct acgtcgacgg caagaaggag
      241 gccggccagc tcgtcgtcct gtacggcacg gccaccggcg tctcgtccgc caagcggcac
      301 accatcagcc agaacaccac cggcgccccc ggcaccgccg aggccggcga ccgcttcggc
      361 tacgacaccg cctacgccga cttcaacggc gacggctacg acgacatcgc ggtcggcgcc
      421 cagggcgagg acgccggcag cgacgtcgac ggcggcggcc tggccatctt ctggggctcg
      481 gcctccggca tcaccggcaa gggcgtcacg gtcgccgacc cggcccccac cgcgcacgac
      541 cgctggggca agaacctcgc ggccggcgac ttcgacggcg acggcaaggc cgacctggcc
      601 gtgggcagca acaacaccac ggtgtacgtc ctcaagggcg gcttctccag ctccggcacc
      661 cccggcggcc gttacaccgt caagcccccg atcgtcggca cggaactgaa cggccccctg
      721 aacctcaccg caggcgacgt caacggcgac aagcgcaccg acctcgtcat cgacggctac
      781 gagaaccaga ccgagtacgg ctggaaccgg aactactacg tccccggctc ctccaccggc
      841 ctgtccacgg ccaacatccg cacgatcaag cccggcgtga tcaccgccat cggcgacatc
      901 gacaacgacg gctacggcga catcgtcagc ggcgccgcct ggaacgccac cgcctccgac
      961 ggcacctccg tccccgactc cgccaagggc ggcaaggtct gggtgacgta cggcaccgcc
     1021 tccggccccg gcacggccac cggcatcacc caggacaccg gcaacgtccc cggcggctcc
     1081 gagaccaacg acatgttcgg ctacgagctc gacctcggcg acatcaacgg cgaccactac
     1141 ctcgacctcg ccatcggagt cgcgggcgag gacttcggca gcgcggtgaa caccggagcc
     1201 gtcacgatcc tgtacggcgg cccgaacggc ctgaacacca cctcgggcgc gcagtccctc
     1261 gcgcagagca ccgcgggcgt ccccggcaac gacgagaaca acgacatgtt cggcatcgac
     1321 gtcaagctgg acgacgtgag cggcgacggc aaggccgatc tgatcgccgg ctccgccgag
     1381 aacgacggca acggcggcgt cacctacctg ccgtccaacg ggtcgaagat caccaccacc
     1441 ggctcccgca ccatcgcccc gagcacctcg ggcgtctcga cgacgggctc gccgtacttc
     1501 ggcgcgaact tcgccgactg agccgccgta cgcgacatcc ggccgggccc gtccctccac
     1561 gggcccggcc gtccaccacc cgcaggagac cccacatggc ccgcctcccc gccctggccc
     1621 tcgcgacggc gaccgtcgcc gcgacgctca cgctcctcac ccccaccccc gccaccgcgg
     1681 cccccgccaa gtacgccgac gacttcaacg gcgacggcta ccgcgacctc gccaccgccg
     1741 ccccgtacac cccggtcggc ggcaagaccg acgcgggcgc ggtcgtcgtc aactacggct
     1801 ccgcgaacgg catcagcgcc gcccgccgca ccgtcatcac ccagaacacg gccggcatcc
     1861 ccggcaccgc cgagcagggc gacaagttcg gccgggccct cacctccggc gacctcaacc
     1921 gggacggata cgccgacctc gtggtcggct ccacgggcga gaacgccggc gcgggtgccg
     1981 tagtgatcgt ctggggcggc aagaacggcc tctccggcgg ccaggtcgtc cccgacccgg
     2041 cgacctcggc ccatgacgag tacggcatgt ccctgaccgt cggcgacttc agcggggacg
     2101 gcaaggcgga cctcgccgtc ggcagtaccg gcagcgacat ctggatccac aagggcggct
     2161 tcctcaaggc ctccggcgcc gcgtcccgct acaaggtcgc caccgacctg tacaccggcg
     2221 ccatctacgg ctcccagcac ctggccgccg gcgatgtgaa cggcgacgcc atcgccgacc
     2281 tgatcgtcag cggcacgcag gcggagacat acgacaacgg caccttcgtc taccagggcg
     2341 ccgcctccgg cctcgcccgc aagaccttca tcaagaacgg cgcctacgag ctggccgcgg
     2401 tcggcgacct caacggcgac ggctacgccg acgtggtcac ctcgacgtac ggcgacgacg
     2461 gcacgacgag cctcggcggc tccctcaacg cctacctcgg cagcgccgac ggcctgcgca
     2521 cccgccccca gaccacgatc acccaggaca cccccggcgt cccgggctcg gacgaagaag
     2581 gcgactggtt cggcaacgcc ctctccatcg ccgacatcaa ccgcgacggc tacgcggacg
     2641 tggcggtggg caccctgcac gagacgatcg gcacggcgaa gatcgcgggc agcgtgacgg
     2701 tgctccgcgg ctccgccacc ggcctgacag ccaccggcgc ccagtccttc acccagaaca
     2761 cgtccggcgt ccccggcacc gccgagtccg ccgaccgctt cggcgcctcg gtacgcctct
     2821 ccgacctgac cggcgacggc cgggccgacc tctccatcgg cgcggacggc gagaaccacc
     2881 cggcgggcgc catctacagc ctgcgcggcg cggccactgg cgtgacgacg accaaggcga
     2941 ccagcttcgg ccccggctcg ctgggcctgc cgacggggta cctgcggctg ggccaggtga
     3001 tgctgggctg accaccccct aggtagggcg tatatctgcc cctaggggat gtcacagctc
     3061 ggcagcaatg gggggcccga atgccggggc ccggcacgcg attccccggg accaggtacg
     3121 ttcgaagacg tggctggatt caggatcgga cggggcagcc ggaacaacgg caccccgcaa
     3181 acgcgccccc aacaacctcc gtacgggcag caggcgcccc agggaccgtc gtacggctat
     3241 cccccgccgc cgcagccggg cggcgggggc ggcggcggct ggccgcaggc gaacggcggc
     3301 ggtggccacg gcggttacgg cggccacggt cagcagggcg gtcacggggg ccacggcgag
     3361 ccggagtact tcggcgacga cggcggctat ccgcacaacc ccccgcacga cccgtacgcg
     3421 gcgaacaacc cgggtcacac ccaggcgttc tcggtcaacg acgaccccta caaccagggc
     3481 ggcacctacc aggcgggcgc ggccccggcc ggcccgatcg gcccccgcct gcactggaag
     3541 cccctgctgc gcggcgtcgt cctctccccc acccagacgt atctgcagat gcgggactac
     3601 acgatgtggg gcccggccct gatcgtgacg ttcctctacg gcctcctggc cgtcttcggc
     3661 ttcgacacgg cacgagagga cgcgatcaac gcgaccctct cgaacgcggt cccgatcgtc
     3721 gcggtaacag cgatcgcgat ggtggtgtcc tccttcgtcc tgggcgtggt gacccacagc
     3781 ctggcccgcc agctcggcgg cgacggcgcc tggcagccca cggtcggcct ctccatgctg
     3841 atcatgtccc tgaccgacgc cccccgcctg gtctgcgcca tgttcgccgg cggcgacgcg
     3901 accttcgtcc agatcctcgg ctgggccacc tgggtggcgg gcggcgccct cctcaccctg
     3961 atggtctcca agtcccacga cctgccgtgg cccaaggccc tgggcgcgag ctcgatccag
     4021 ctgatcgcac tgctgtcgat cgtgaagctg ggcacgttct aggcagacgg gtaggagaaa
     4081 ggcccccggc gagaaagccg ggggcctgtt ttatcgacgt gtctcaggcg tcgaggactt
     4141 gcccgtcccg ccggacgaca ggaggcagga cactccacgg aaagttgatc cactcatcgg
     4201 tccgcttcca cacgtactcg cacttcacga gggagtggga cttctcatag atcacggcgg
     4261 accgcacctc ggcgacatgg tcgaggcaga agtcgtggac gagcttgagc gtcttgcctg
     4321 tgtcggcgac gtcgtcggcg atcagcacct tcttgtcggt gaagtcgatg gcgttgggga
     4381 cgggagcgag catgacgggc atttcaagcg tcgtgcccac acccgtatag aactcgacgt
     4441 tcaccagatg cagattcttg cagtcaaggg cgtaggcgag cccgccggcg acgaagaccc
     4501 cgccccgggc gatgctgagc acgatgtcgg gctcgaaccc gtcgtcggcg atggtctgag
     4561 caagctcacg gatggcgacg ccgaaccgct cgtaggtgag gttctcgcgg ttgtccgtca
     4621 tacctgggtc cgatggaagt tctggaagga ccgggaggcg gtgggcccgc gctgcccctg
     4681 gtaccgggat ccgtaccgct cactgccgta cgggaactcg gccggcgagg agagccggaa
     4741 catgcacagc tggccgatct tcatgccggg ccagagcttg atggggagcg tggcgaggtt
     4801 ggacagctca agggtgacgt gcccgctgaa ccccgggtcg atgaacccgg cggtggagtg
     4861 ggtgacgagc ccgagccgcc cgagcgagga cttcccttcg agccgggagg ccagatcatc
     4921 gggaagggag atcacctcgt acgtggaggc gagcacgaac tccccgggat gcaggatgaa
     4981 cggctcatcg ccctcgggct cgacgagccg agtgaggtca acctgctcga ccgaggggtc
     5041 gatgtgcggg taccggtggt tctcgaacac ccggaagtac cggtccagcc gcacgtcgac
     5101 actcgacggc tgcaccatgg tctggtcata gggatcgatc cgtacccgcc cggcgtcgat
     5161 ctcggcccgg atgtccttgt ctgagagaag cacgccccga ggatacgcaa ggcgcgcgga
     5221 ccgacgacaa tcgcacggcc cacgcgcccc tgttccgcta ctactgctac cgctaccgct
     5281 tctcgaactg caccggcacc acactgcgga gccgggcaca ccgaggacac cggacgagcc
     5341 ggccggggcc gaggcgctcg gcctgctgca tcgggaacga agcggtgctg aacacgtgcc
     5401 catcggcaca acggacgacg gtgcgctcca tcaagtccaa gagtcccttc cccaagagcc
     5461 gcgtctggct gctgcctgcc tgacgacgag aggccacatt acgggatcaa agggacggcc
     5521 ctccaggcgg cactccgccc cacccggacc ctctcccacc cctccaccgt acgccccaac
     5581 tccggccccc cgcagccgga tcccacccct gaatcgaccc ccgcctccat ggcgtcagcg
     5641 cccggcgccg gtgatggggt agagtgacga agcgttcgga caccgcctcc ggatcatcac
     5701 ggagcgggcg tcttacgcgg gtgtagttta atggtagaac atcagcttcc caagctgaga
     5761 gcgcgagttc gattctcgtc acccgctcca gagaaaaacc ccaggtcagc gaccgggggt
     5821 ttacttgttg actagaccat tctggggggc tccgtgcccc aagtcgcgcg aatgcgcaat
     5881 ggcgagacgc attttccatg agctgggcca catagtcagc aaacggtacg caagtcacgt
     5941 acgcaaaggg cgacttgctg acgcgcggcc cgacgcgacg cactcgcccg ccggatacgc
     6001 ctgctggtcg ccgcgaccat caccacaatg ccgtggcccg cccgtttcgt tggaactggg
     6061 ccagccccgc cagactgggg acgacggtgc cgcccgccgc tgcgaaccgc tacatcctca
     6121 acccgccggc accaccgccc gcatccacca gcacctcaac atgggcgagg tcgacttcga
     6181 cgaactcttc cgcgagctgc gcgcgaacgg cttcgacggg acgctcacca cctgtgtgtt
     6241 cgcccgggag gagaaggcga aggagtcttc cctgttcaga ccgaggcgct ggccgtgtcc
     6301 gggcgctcgg cggtaggggt ggcgggcagg agggtggacc gtgtgccgtt tccgtcgacg
     6361 gtgcggcgcc gggagcggcc ctcggtggcg tggaagtcga aggccgtggg cctgtgcggc
     6421 caggcggtcg tcgtcgcgac gcaggtggac aggaactcgt cgacaccgtc gagtgccacc
     6481 tcgtccggca ggggctgcgg ggcacccagg acgacctggg cgtcgtaggt gtgcaccacg
     6541 gtctcctgga cccggtgccg ggcgacgccg ccggcgttcc gcggcgactg cgacgtaccc
     6601 caccacgtcc ggcaaccgcg atccgggccc tcctcccgca gcgcgcccag cagcagccgc
     6661 gtcgacgcgg ccgaccaggc cggcagggcc tcgcgcgctc ggcagcggcc cagaagcggt
     6721 cccccggccc aggtgctgca ccagatcgaa cagcgtccac tcggggcagg tcggcacctg
     6781 cacgtcgagg tcgggcgcgg cggcgatcgc ggcacggaag gaggtcgacc gttcgtcgag
     6841 caaccgcagc aggtcggaga actcgagtgt catgggcacc acgcgtgttt atcgcccgcc
     6901 ctcgggcgac acggtgcccc cattccgaaa cgccgccacc gcgttcaccg ccatcgccac
     6961 tgtttgcccg catatcaacc gttccgcacc acccggccta tcctgacagt gagtggccaa
     7021 cgtcgatggt cagggggttc tcggacgatc gagggagcac cccatgagtg cgtgccggag
     7081 gcgtacggcc atcgccgccg tgttgtcgcc ggccatggcc gtgtccctgg tggcctgcgg
     7141 acagggaggg gaatccgccg gctcgggtgg gaccgcgccc ggcgagggcg gcttcgcgat
     7201 cggtctgctg ctcagtcaga acgtccagac tcgctgggag gcgttcgaca agcccctgat
     7261 cgagaagaag atcaaggagc tgtgcgcgga ctgcgcgacg gagtacgcca acgccgaggg
     7321 ggatgtggcc acgcagcagc aacaggtaga gaccttgatc gacaaggacg tcagggtcct
     7381 gctcctcagc gctgtgaact tcagatcact ccgttcctcg gtcgagaggg cacacgacgc
     7441 gggcatcccg gtcgtcgcct acgacggcct cgtcgagggc ccgatcgcgg cccacgtctc
     7501 cttcgacaac gaacaggtcg gcagggtcca gggcgaggcg ctcctcaagg ccctgggaga
     7561 caaggcggag ggcggccaga tcgtcatgat gaacgggccc cagacctccc cgacccacct
     7621 tgccttcgag aagggcgcgc ggtccgttct ggaaggcaag gtcaggatcg gcaagacgta
     7681 cgacactccg ggctggagcc aggagacggc ccacaccaac atggacggcg ccatcgccgc
     7741 cctgggcgcc gacagcatcg acggcgtcta cgccgccaac gacggtctcg ccaccggcgt
     7801 catctccgcc ctcaaggccg ccggcatcga cccgctgccc cctgtcaccg gccaggacgc
     7861 cgacctcgcg gccgtgcggc gcatcatcac gggcgagcag tacatgagcg tctacaagcc
     7921 cttcaaggcc gaggccgacg cggccgcgga gatggccgtc gccctgggcc gcggcgagaa
     7981 gctcgacagg atcgccgaca ccacggtcga cacggccacc accaaggaca tccccgccgt
     8041 cctgctcgac cccgtcccgg tgaccgtcga cgacatcaag gccaccgtgg tcgaggacgg
     8101 cgtgtacacg accgagcaga tctgcatccc ggagatcgcg tccgcttgca agaaggccgg
     8161 actcaccgag tgacaccggt tggcacgaac tgccgctacc cggaaaggac gtcccccgtc
     8221 ccctgggccc gtgccaggaa gcggtagtgc tcgctggtgc gcaggagttc gtcgtgggtg
     8281 ccggtggcga cgaccctgcc gccgtcgagg accacgacga ggtcggcggc gcggatcgtg
     8341 gagtaccggt gggcgatgac cagcagggcg cactcgtggg tgatccgtcg gatcgagcgg
     8401 cgcagggcgg cctcgttgag cgcgtccagg tgggccgtcg gctcgtcgag gaggaggagg
     8461 gaagggtggg tgagcagcga gcgggcgagg gccacgcgct ggcgttcgcc gccggacagg
     8521 gccatgccgt gttcaccggc cggcgtgtcc agtccgtacg gtgaacgggc caccacgtcg
     8581 gagagctgcg ccagtcctac gacccggtcc agttcggccg ggtccgcgca gggggcggcg
     8641 tacaggaggt tctcgcgcag cgtgccgtac agcacgggcg cgtgctgctc caccaggccg
     8701 atccgtgcgc ggtgttcggc cgggcccagg gtgcggatgt cccggccctc gaacaggaca
     8761 cggccggcgt cggggtcgta gaagcgctcc gcgagtgcga agacggtgga cttgccggcg
     8821 ccggaactgc cgatcagggc gacgtggccg cgccgcggaa ccgtgaagga gaccccgcgg
     8881 agcacggggc ggcccggctc gtagcggaag cggacgtcct ggaattccag cacggggacg
     8941 tcgtgggccg gtctcgcggg ccggcgctcg ggttcgggtc ccggttcgcc gggcaggtcg
     9001 aggacctcgc tgatgcgccg cagcgcgccg aggccctgcc gcatggtgct cagcgcctgg
     9061 aagacggcgg cgaccgggga catcagatag agcatgtaga ggaggaacgc ggcgaggtcg
     9121 gcgaccgagc cgtcctcgcc ggcgacccgg atgccgccga tcagcagcac caggaggaac
     9181 gagccgttga tggtgagggt gatcgcgggg gcgaccaccg cgtccatcgc tccgacccgg
     9241 acgctctggc ggtacgccga ccgggcctcg gccccgatcc gccgcgtctc gcgctcctcg
     9301 gcgcggctgg cgcgcacggt ccggatggcg cccagcgcgc gctccagttc ggcggtcatc
     9361 gccccggtgg cctgctgggc atggagtgag gcccgctcga taccgcgcag caccgacgcc
     9421 accgccaccg agccgaccgc gatcacggcc agcacgatca ggaacagcac ccagtcgagc
     9481 cacaccatca gaatcacgac gccgacgagc ccgacgaggc cggtgaccgc gtccgtgaaa
     9541 ccctcggaga ccagcagccg cagcgcggtg ctgtcggcgg cggtcctggc gatgagatcg
     9601 ccggtgcggc tgcggtcgta cgtacgcatg ggcagccgca gcaggtgggc gatgaggtcc
     9661 aggcgcaggc ccaggacgac gccttctccg gtgcgggtga gcacatagcg cgccaccgcc
     9721 tggacggcgg cctgcgcgag gaagagcacg accagcaggc cgatggcacc acccgtcgcg
     9781 aggccggcgc ccgccgcctc gatgacccgc ctgaccacca agggctgtgc cagggcgagc
     9841 gcggagccgg ccgcggccag cgcgacggcc agggagatcc tgcggccctg gccgcgcagg
     9901 acgcgccgga cctcctgcgg gcccgtacgg cggcggccgg ggctggtcgg tccggtcggt
     9961 gagtgcagtg ggtggtcccg agggtcgtcc tgtgcgtgct tcatacggcg ctccccgggg
    10021 accccatggc cctcggactc ccggcctcac tccccgcccc gctttcctcc cccgctctcc
    10081 ccacctgctc ggagccgacg cgctgcagca cggcgaagcc ggtccgcagt cccgggatgt
    10141 cgcccagcac ctcgtcgtac agctccgccc aggcgtggaa ggcgaagcgg ccgccgatcg
    10201 acgagcgctg ccgggccacg acgacctcgg cgggcagtcc gagcgtggtg aggtaggtga
    10261 cgagcgcgta cgagcggggc aggcacaacg cgtcggggtc ggccagccgc agccaggtca
    10321 ggcagggcag cacctcgcgg cgggcgagcc ggaccgcctc cgcgggctcc caccggggcg
    10381 ggcacgcggg ccgcagggtg cgcagatatc gctgggcgtc gggccagccg cgccgccgca
    10441 gcaggcgcgc ggcgcggacg gtgcgggcgg cggcgagcag ccgtgcccgg cggggcgggc
    10501 ggggcggcgg gtcgggctcg gggtcccgga ggaggaactc ccagtcggcg gcggggtcgt
    10561 tcatggcgcc gcggtcgggt cggtgccggg ctcggcgagg tggttctcgg tgagccggcc
    10621 ggtgagggtg gcgaggccgt cgcggagcat ggtgtcggtg gcatcgatgc gctcgccaag
    10681 gtgtcgtacg gcctcctcgg tggtgtcgta ccggagtgcg gcctgcagca tgagggtggc
    10741 cacggggttc agctcgtaat aggcgccctc ggcaccgtcg agcagcacgc cggtgccgtc
    10801 ggcggggtcg aaggcggtct gctcggtgag ccggagcagg ggcatggcgg tcacctccgg
    10861 tcgtccgccg ccgaggtacg ggggcggcgg ctcaggtgtg cttcgagatc gcgcaggaag
    10921 agctcgacca tcgcggaaca gagcaggttc tcggcgttgc ggcgcagtgc ccccgggtcc
    10981 ccgagcacct cgtcgaggcg ccgcggatcg acgacgccca gcgcggtcag ccgggcgtcg
    11041 gggtcgccca ggatccgggc gagcgccccc gggtggctga ggcaccaggt ctcgtcgggc
    11101 gagcccagcc aggtccgccc gtagtgacgc cagatgtcgg gcggcagcag atcggcggcg
    11161 gccagtcgca ggacgggctt gtcgatggtg cgccccgcgt gcgggatcag ccggtaggcg
    11221 tcgggcagcc cggccgcgag gcggcgcagc gaccggccgc cgagcggttt ggcgaggtgg
    11281 atgccgcgcg ggcgccacag agcgaggttc agcgtgtgtt cctggggcgc gaagtccagg
    11341 tcgtacggtt cgggggctgc gccctgcacc gggacgagga agtcgctgcc gagttcgacc
    11401 tcggcgagcg cctgcgggtc ggcgtacagg gagtacgagg gccgggcact gcgcagaatg
    11461 cggctcagct cccagcgggt gccgagcagt ccgcgcagca tccgccactt ctcgtacgcc
    11521 ggcacctcgc ccgcgaggat gtcgtacagc ccgtaccgca gcgggccgaa gagggtgtca
    11581 ccctccaggc ccgacagaac gacgcgcacg ccgtccgccg cgatccggtc ggcgacgcgc
    11641 tccagggagc gcggccagac gtggttgaag gggtgcgaga agtcgcacgt ggtggagaag
    11701 tagtcgtcgt cggtcacgcg ggggacggtc accaggggga cggccaggcg ccggcacacc
    11761 tggcgggcga agccggactc gtcggcggcc gggtcgtccg tgcccatgtg gtaggccgtg
    11821 acgtcggcgc cgtgctccgt gagtgcggcc aggacgaggg ccgagtcgac gccgccggag
    11881 agcaggatgc cgatcctgcc gccggtgcag gggcgggtct cctccagcag caggtcgtgg
    11941 gtgagacggg cgtagtcgcg cagggtggtg cggtgcggga ggtccagggg cacggcacgt
    12001 tcgtaggtct cggtccgggt ggcgcggggg ccgaaagcgg tgaactgccc cggccgcagc
    12061 agcccgagcc ccgggtagag caagacgtcc tcgccccggc agctccgcca gagcttctcc
    12121 cggtcgaggt ccggcaggcg tccgtcgaac aggtccctcg ggtcggagga ccaggagata
    12181 cgcgttccgg tcctgcggtg gaagatctgg tcggggctgg agagcccgcg gaagacgagg
    12241 atccgctccg gtgtgacgac gcagccggag agctccgcgg ggagcgtcct gaggatgccg
    12301 gcgacggttc gaaagtgcgc gtcggccgtc gcgtcgacca tgcgctggac gaattccaat
    12361 gatggacggg atatcagggg tccggagaaa agaacgcagc ttccgttatc ggtccggggc
    12421 gaaatcccgg gagatccagg actcaaccat tgaagcgaaa agtatttctc cgccggaatg
    12481 tgctcgggga ttccggaggt gccgagtgcg gcatgtcccg agcaccccac gaagtccacc
    12541 gccaggtgcc gacgggatgt gacggcccct ccccgaccga cagttgtggc aggtgagggg
    12601 ccgggccgat tgctggtcac agaatgttgc cgtgaccgag gaggtcaggc acgccacgac
    12661 gaagctgccc ggtcagttcc tcgattcgcc ccaggcaggt gatggttgga gcggtgtact
    12721 tcagcatggt ttctcacctt cttccctcct ttaccaatct aatacggccc gctccggata
    12781 tccgtccgag caggccacgg gatgacaaaa tgaggttgac caggcaatca cgacggtccg
    12841 gaaaaggcgt gaagaacatc gcgagggcag cggtgaaggc gaggatggcg agtgcggcgc
    12901 gcagtcggtc cgtgcgccag ccgacgcgca gggccgcatt gaccgggtca tggtgtccat
    12961 ggatgccggc acctgccggg caatggttcc gcgcagtcgg cctcggtacg gacgacctcg
    13021 tgcaaaaggt gggccacttc agcgcggcgc ccacccgccg gcgagcgccg tgcccactgc
    13081 gtacccaagt cgaggaaaac ccctcagaga cggggggatg gtcgtcccga agccctgggt
    13141 caggccagct tcttgagcat ttcggctgcg gcgggtccgg cggaggcggg gttctggccg
    13201 gtgacgaggt tgcggtcgat gaccacgttc ggggcccacg gctcgccctc ctggtagtcg
    13261 gcgccgatct cgaccaggcg gtcctggagc agccacttgg cgcctgccgc aagaccgctc
    13321 tggatctcct cggcgttgct gaaaccggtg agccggtagc cggcgaaggc gttgccgccg
    13381 tcggcctcgg tggcggccag cagcgcggcc ggggcgtggc agaccacgcc gagcggcttg
    13441 cccgaggtga gggcgttgac gaggagcctg ccggaggtgg cgtcgacggc caggtcctcc
    13501 atcgggccgt ggccaccggg gtagaagacg gcggcgtagt cgtcgaggtc gacgtcctcc
    13561 agcctgaggg ggtgctggat ctcgctgatc gaggcgatgg tgtccgcgat cttcttcgcg
    13621 ccctcctcgc cgccgttgaa ctgcggcgcc aggctgccct ggtccagggg cggcaccacg
    13681 ccgcccggcg tggtgacgac gatctcgtgg ccggcggccg tgaacgcctc gtacggggca
    13741 acgagctcct cggcccagta gccggtcggg tgcttggtgc cgtcggcgag cgtccagtgg
    13801 tcggcgccgg tcagcacgaa aaggatcttc gacatggggt ggtctccggg agtcggggtc
    13861 agctgggttg ttgttcggtg ccggccaggg cagcgaggat caagtcgctg acggccttgg
    13921 tggacaccgg gttctgtcct gtgatcaggc ggccgtcgcg cacggcgtgc ggtgtcatcg
    13981 ggacagtgga gcgcacatac ttggcgccct tcgcgcgcag ttcgtcctcc aggaggaacg
    14041 gcaccctgct cttcacgccg gccagtcgtt cctcgaccgt cgcgaagccg gtgacggtgc
    14101 ggttccgtac cagggggttt ccgtcggtgt cgcggaggtt gatgagggcg caggcgccgt
    14161 ggcacaccga ggagacgatg ccgccgtcgg cgtagatggc ctgggccgtt cgctgcaggt
    14221 cggcgctgtc ggggaagtcc cacatggtgc cgtgaccacc cgtgaagaag atcgtggagt
    14281 agtcgtccgg atctgtgtcg gcaacggaag gggtggcttt gagggcgtcc atgaaggctt
    14341 ggtcgtcgag ataaccgcga accgtccggt cgacgaacaa gcggccgagg ctacgagggt
    14401 cgagcggcac ctcgccgccc gccgggctca ccacgtccac cgtgtgaccg gccttcaccg
    14461 ccttgtcgta gaaatggacg agctcgccca gccacagtcc ggtccggtgc tcgctcgtcc
    14521 cgtaggtggc ctgattggtc acgaccgcaa gaatcctttt ctgtctcact tctccctcgt
    14581 ctcctgggcg gcccgtggtt tcgaagctaa agctgttgat gtatcggcgc caatgaaggg
    14641 accgataccg ggtatcgaag aaccgatgcc tggtccgggg acatacggca cctggccggc
    14701 ctgcctacct cgtaggctcg aagccgtgag cgatcacgac attcatgggt ccggtccgct
    14761 ggacctgaac ctgctgcgca ccttcctcgc ggtgcaccgc ctgggctcct tcaccgccgc
    14821 ggcgcgccgg ctgagcctgt cgcagtccac cgtcaccacg cacatccggg cactggagag
    14881 gcgcctgggc cgcgagctgt tcgaacgcag ggcgcaaggc gtcaccccgc tgccccatgc
    14941 ggacgaactc gccgcccggc tgtcggcgcc cctcgaccag ttggccgtca tcagcggcga
    15001 ggaaccgagc agcaccgtgg caccggtcca tctggcggga cccgcggagt tcctgggcac
    15061 tctcggcctc acggtgctgg ccgagctggt cgcgcagggc gtccggctgc gggtggccac
    15121 cgggctgacc gaagtactgc tggaagaact gcgggccggg cgccacgacc tcgtcgtcgc
    15181 cacccggcgt ccccgtggcc ggacgctgca cgccgaactc ctcggcgacg aggagttcgt
    15241 cctggtcgcc gcaccggtat gggcagaacg gctcaagggg caggagctgc caactgccct
    15301 ggagagcctc ccgctgatcg cctacgccga ggatctgccc atcgcccgcc gctactggcg
    15361 ccatgtcttc gaccgccgtc tgcacgccca ggccgcgatc accgtccccg acctgcgcag
    15421 cgtcctcacc gccgtcaccg tcggcgccgg ctggagcgtc ctgcccggct atctgtgccg
    15481 caccgaactc gcctccggcg tcctccgtct gctgcaccag ccggaggacc cgccgatcaa
    15541 cacctcctac ctcgtccagc gcccgggcag ctccaccaac ccacacgtga cactcgtccg
    15601 cgagcacctg ctggccgccg cgaagacctg gtgagccgac ccggcggcgg cggggcccga
    15661 ctggatgccg atgtgcgatg ccgaactgcc cgcccgggat ccgccacatg acaagacgca
    15721 tcggcgctgc gaggatccgt gctactggca ctgcggacac cacaccgtgc cgcggcctgc
    15781 cacgcgggac cggcgtaggg agtggccaca gcgggggcag gccggatcgg ggtcgtcgcg
    15841 gtggccggtg agccaggagt cgcgcggcgg gacgcagccg gcggcgaccg tggagcgcag
    15901 ggtgcgacgc atgtgcgtgt acaggcgacg gcagtcggcc tcggcgaggt cgctcgcccg
    15961 gctcgtgggg cgcagtctcg cccgccacag gatctcgtcg gccagcagat tgccgagtcc
    16021 ggcgaggacg gactggtcgg tgagggccgt tttgacgctg ccgcgacgtg cggagagcac
    16081 gtcctcgaac tccttgcggc tcacggccat cgcgtcgggc ccctggcgct ccaggagccg
    16141 tgcgacctcc gactcgtcgt cggccagcca gagtccctgc agcttgcgct ggtcgcggta
    16201 gcgaagctga cggtcacggg ccacggtgaa caggacgcgg tcgtgcgcct cgaccatgtc
    16261 atcgggatga cagcagacca gttcgccggt catgccgaag tgcagcatga gggtgggacc
    16321 gccggtgcgg gcgagcagcc acttcccgtg ccgctccggc tcggtgaaac gccggccctc
    16381 caccgcgtcg cgcagccgcc tcgtgctgac tccgtgcagt acgccggtgt cgcgcacgtc
    16441 gacgcgttgg atgatcctgc ccttcgcgca ggacccgagc accttccgga atccctcgac
    16501 gtccggcagc tcaggcatgc gtacgtcctc tcacgcgccg ctccacccgc tcggtgagtc
    16561 ggccgctctc tcccccagaa catggtccct ctgggcaggt aacggtgcag caccgcgcac
    16621 cccggtaatg gcagccttgc actgggcatc cgggccgggt tgcgcgatca cacaggctgc
    16681 catcgggccc gaaccgtcag acggcatcat gcacgcatga tcaccattca tctgaagtac
    16741 gagatcgacg ccgacaagct tgcggacttc gaggaatacg gccgccgctg ggtccggctc
    16801 gtcaaccgtt tcggcgggac gcaccacggc tacttcctgc cgagcgaggg cgacagcgac
    16861 atcgcctacg ccctcttctc ctttcccagc ctggccgcgt acgagcagta ccgcacggac
    16921 agcatgtccg acccggagtg ccaggaagcg ttcgaactgg cccgtgacac ccggtgcatc
    16981 aagcgctacg agcgccgctt cctccggccg ctcgacggcg tgtcctaggc cggcggaagg
    17041 cgcggggtgc ggttctcccg cgcggcggtg cgcagcgctg cgacgacggc cgtggtcgtc
    17101 gggttcgcgg tctcggtgtg acgcgtcgcg gcgaacagca ggcgcgggat cgggtgattc
    17161 ctcgatggac gccgtgcgga ttccgggtgt ggccgggtcg atggccgtcc gagggagggg
    17221 cgcggtggcc aggccggctc gtgcgagggt gaatcgggcg gcgatgtcgg cggtgatgta
    17281 gcgcgtcgtg ggcgtgaagc cgacctggtg gcaggcgtgc aggatggcct gcccgcagtc
    17341 cgtggtcggg ggcggcagga cgaggctgta cacggccagt tcccgcagtt gcgcctggtc
    17401 ggtgaccaga caggtcacgg tgagctgtgg gtggtctgag cccagcagag cgttccggcg
    17461 gccctcgggg ctctggtgtc ttacgaaacc cttacgcacc cgcacggtgc ggggtcccgc
    17521 acctacgatc gccgcgtgac gacctctctc gtgacgacct ccatacgcat cgccctggtg
    17581 accgccgcgc ccctggcgtt ggccgcagtg ggccttgtac acccccacgg actgtcgccg
    17641 tcgacggcgg cggactggaa ggacctgcac atcctgctgt tgcctctctt tccgctgctc
    17701 accatcggtc tcctggtccc gctgtggcac cggccccggg ccggcatcga aggcgccgcc
    17761 acggtcgcgg cctgggccgg tgccttcgtc tacgcggcct tctacaccgg gctcgacgcc
    17821 gtcgccggga tcgcggccgg aaccgcggtc gagcacgccg ccgcgggcgc ggacccaggg
    17881 ccgttgaaac gcccgctcta cgaggtgggt gagtccctcg gacaggtcgg cgcctacgca
    17941 ctgatctgcg cggtcgtgtg cgcctcggcg gcactgtggc cacggcacgg cgcccgcgtc
    18001 ctgccgggca cagccgtact gctcgtggcc ggctggtcct tcgtcgacag ccacatcttc
    18061 tggccacgcg gggtctggac gatgtgcggc ttcgccctgg ggttcgctct gctcgcctgg
    18121 gcgaccgggt cccacagccg gcaccggccg cggacagcgg gctgaaggca aaccctgtgc
    18181 cgcgcggtgt gcggtcgcat gcccgcacgg gtgggtccgg cgggtaaccg tgcctctgac
    18241 cctcaggagc agccgcgtca ctcgaccggt tcgagggcgt caccgccttg tcggtggcct
    18301 gcaaggcagc gcacacggcc ttctcgggcg gcgaccacgc tcaccgcgca ggacgagccc
    18361 gccgagcccc tcgcccctgg cgcaccgagc ggacgtgtga atcggcctgc acagcccgtc
    18421 gattcgcgtg ccgacgctct gacagccact gcttacaaga gtctgacgcg gagctcgttc
    18481 ccctctcgtc ccaccacacc cactggccac tcttgtcccg tccgcaggaa cggataccga
    18541 aacgggtgcc catgggcaac ggagctgaag gagacgggac atgagcacgc acagcagccg
    18601 caggggtcac cgggggaagt ccaggacacg gcggatcgtg atcggcggcg gagccctcgc
    18661 cgtcgccggg gcggccacgg tggccgtgtc cctggcctcg gccggtcagt actccgggag
    18721 cgccggtgcc gaccacgccg tcttcgtcca gggcaacgaa ctggacggca acaccatcca
    18781 tgtgttcgcg cggggtgacg acggcaagct cgaacccgcg gggacctacg acgccggcgg
    18841 caacggcggt gaccaggtcg acgccccaac cgactcgctc gcctcccagg gttcgctggt
    18901 ctacgacgac gcctcgggga tgctgctggc ggtcaacgcg ggcagcggca cggtgacgtc
    18961 cttccgcgtc gagggccgga cactgaagga ccgccaagtc gtggactccg gcggggagtt
    19021 cccctccagc atcgcggtgc acggcaaggt cgcgtacgtc atgaacgcgg gcggggaagg
    19081 cagcgtccag ggtttccgga tcaccggcaa ggggctcaag ccgctgcacg gctcccaccg
    19141 ttccctgggc ctggacaacg aggacatacc gcgcttcgac acctcgcccg gcgaggtcga
    19201 gttcaccccg gacggccgca acctggtggt caccaccaag ggcaacaaca ccgtcgaggt
    19261 cttcccgatg aagcgcaacg gcctcccgtc cgtcgccgaa ccggtcgtca acgagtcggc
    19321 cggaggtgtc ccgttcgcga tcagcttcga cgggaccggg aagcggatgc tggtcgccga
    19381 ggcggagaag tccacggtca ccacgtacca ggtcaagcgt gacggcaagc tgaaggtcct
    19441 tcagaagccg ctcgccaacg ggcaggaggt cctgtgctgg ctggagcgcg cgggcaactt
    19501 cttctacggc ggcaacaccg gcaactccac cgtcagcggt taccgcatgg acaagcacgg
    19561 caagctcgcc ctgaccaacg acgtcggcat cgccaccccg ccctccgcca actcccaggg
    19621 tgtgatcgac ctcgcggtga cggaggacga gaagttcgtc tacgtccaga acgccgtctc
    19681 cggcaccgtg gacggcttcc gtgtcgagag gaacggatcc ctcacgaagg tcaccacggc
    19741 tgagggactg cccgccttcg acgagtcggg catggaaggc atcgccgcga tgtgacacac
    19801 ccgcgtacgc atgcggcccg gggcatgggg cggcctgcga gggggacagt ccccgggact
    19861 gtcccccttg cggggacgtc cgtgacggcc cacacggttt cgcaccgcag ctgtggttct
    19921 cactcgtcga agggcttgcc ctgatcggcg gtggtacctg cgggcagctg atcggccacc
    19981 gtgctcaaga gcgttgacga aggtcgtaga agcggaagcc gtacgggcgt gccgccactt
    20041 acggccgaag gaggtgcgcc ggaaagggtg cccccccctc tcgcaggcgg cccagatcag
    20101 ctcgggctcc tctcgggagg cgccgcaggg ccacttccag gtcatctcgg ccgtcttcga
    20161 tctcgatgcc gggactctca taagggccag tccagcaacg gcgtccggcc gcaggtactc
    20221 ggcctcaaca cgtcgcaccg ctgcccgggt tcgggcagat acgcccggaa cctgacggac
    20281 cggcacgtgc ttgctgccca ggccgatttg agggcggcgt gcccttcgcg tcccttggat
    20341 ggaggcgaaa cgacggctca ggcgggctgg gtgggggccc gtagttcgat ctcgtatccg
    20401 ccgtgtggcg tgggttcggc gatgagggcg ccgcctagca gttcggcgcg ttctctcagg
    20461 ccgatcaggc cgtgccgggc gctgggcagg gcgacggacg ggcgggtggg ggcggtgttg
    20521 gtgacggtga cgccgaagtg ctgcgtgtcg tgccacaggc gtacctcggc gcgggcgccg
    20581 ggggcgtgct tgcgtacgtt cgtgagggct tcctggaccg tgcggtagac ggtgcgctgg
    20641 gcggttgtgc tgatgccggg cgggagcccg ccggtcaggg cggtctcgat gccgctgttg
    20701 gcgatcagct gctggaggtc ggcgagggtg ggctgggggg tgagttcggt ttccttgccg
    20761 ccggaggcgc gcagcagggt gaccatgtgg cggagttcgt cgagggtgtt cacgctcagg
    20821 gtgcggatgg tgcgggcggc gtcgcgggcg tcggggtcct tggcggcgac ctgcagggct
    20881 ccggcctgta cggcgatgag gctgacctgg tgggagacga cgtcgtgcat ctcacgggcc
    20941 agctgggcgc gttcgcgggc gaggacggtc tgggcgtaca gggcgcgttc gtgctcgcgg
    21001 gccacttgga cctcgacgag ccggcgggcc acgtcgtgtc tggcctgcac gagctggccg
    21061 cacaggatcg gggcgaaggc catggccagc gtgtagacga actggatgag cgtccaggtc
    21121 cggtcaccgg gaaacgtgtc gtcggaaaac gtgtcggaca ggggccaggc gagggtgctc
    21181 gccgccgcgt tcagcagggc gcagccggcc agcagcgggc ggttgcgggt tcgcgcggcc
    21241 agtgtgtaca gcgcggtgat cggcgcgact cccacgtcca tgaacagcag catgggcagt
    21301 gtcagcagga agacggcgag cgggaagcgc ctgcgcagga gcagtccggc gctgccgagg
    21361 gcggcgcagg cccacatgac tggtgtcgcc tcgtcgtcga ggttgatcca ggcgtcgagc
    21421 gcggcgagca cgacgaggcc cgcgtcgacg gcccagggcg gcaaccgccg ccacagtgcc
    21481 tgacccgtgc tcatcatcca ttgctccgtg ccgtgtcggc gccgtcgtcg ctgagcagtc
    21541 cggcccgctc cgcgaggagc gccgcctgga cgcggctgga gacccggagt ttggtcagga
    21601 tcgagctgac gtggtccttg acggtgcccg cgctcagatg gatgcgggtg ccgatgtcgg
    21661 cgttggacag cccttccgcg atcaggacga ggacgtcacg ttcgcggtcg ctgagcagat
    21721 gcacgcgcgc cacgcccgcg tcctggggcg tgcccgcccc cggatggccg cgcagcagag
    21781 cccgcgaggc tttcggggac atgacgacgc cgcccgcggc cagggtgcgt accagttggg
    21841 cgagttgttc gggctcggtg tccttgagca ggaagcccgc ggctcccgag cgcagcgcgg
    21901 tcaggatgta ctcgtcggtg tcgaaggtgg tcagcatggc caccgtcggc ggctcgggca
    21961 gcgtctggat ctccctcagg acggtcaggc cgtccacgtc cggcatgcgg atgtcgagga
    22021 gcacgacgtc cgggtgctcg cgccggatcg cgtcggcggc ctgcgctcct tccgcggtcg
    22081 ccacgacctg gatgccgtcg gaggcgttca ggatcagctc gaacccggac cgcaccaggg
    22141 cctcgtcgtc caccaccact acccggatca ccggcgttcc gcctcaccct cgtctgcttg
    22201 atcgctcgct gtcgacagta cgtccggcca ggcgcgcgac gggacggccg ctgtggactc
    22261 cagccacccg gcaggggggt tccagccgct cggggggagc gctccggccc atcggcgggc
    22321 gggtgggcga ggctcggcgg a
//
