LOCUS       NZ_BNBM01000015        21107 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence15, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000015
VERSION     NZ_BNBM01000015.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 262179)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 61053
            Orig. end                         :: 82160
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21107
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="furan"
                     /region_number="1"
                     /rules="(mmyO or AvrD)"
                     /tool="antismash"
     cand_cluster    1..21107
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(mmyO or AvrD)"
                     /kind="single"
                     /product="furan"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21107
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11107](+)"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11107
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     misc_feature    complement(149..164)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    complement(188..202)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    189..203
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.19"
                     /tool="antismash"
     gene            complement(492..2015)
                     /locus_tag="IE325_RS32280"
                     /old_locus_tag="GCM10018780_65240"
     CDS             complement(492..2015)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139184.1"
                     /locus_tag="IE325_RS32280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65240"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_190073653.1"
                     /transl_table=11
                     /translation="MSTEQAPTTTGDSGRITSDLWWLSGIMALGGFASLLDSTIINVAI
                     GPLATTFDSQISTVQWVVTGYLLALSATIPLSGWASARFGAKQMVLVSQVLFLIGSVLA
                     GLAWDTTSLIVFRLLQGIGGGMAVPVGQALLAQAAGPQRLGRLMGIVSIPAMFAPLIAP
                     SLGGVLVDYLSWRWLFFINVPLCLATIVLAMLKVKNVVEPTKDARLDVIGLILLMPGLT
                     AFLYGLSEAGNKGGFTGGKTVAGLVIGVVLLAAFALYTLRSRLEPLVDLRLFTRPAFRN
                     GTLANLLLSIAMYGVMIPLPMYFQLVHGATVTESALLLLPQSIGYFAGVILINQLTAVL
                     GVRNLTVLGVVLAVVATVPYGLIDADPNPVLLGVAMIVRGFGLGVAMLPTMTLAFSSAP
                     KELAPMATSTFNVFQRVAASIGTAVLAVVLQQHIEDRLPAGGPAAVTQIQPGGDLAKDI
                     ATSFGPPFWWALVFTALAVIPCLLLPRRTAATRQAPREEKESESVVGAG"
     gene            complement(2099..2866)
                     /locus_tag="IE325_RS32285"
                     /old_locus_tag="GCM10018780_65250"
     CDS             complement(2099..2866)
                     /NRPS_PKS="Domain: Thioesterase (22-238). E-value: 6.3e-38.
                     Score: 123.4. Matches aSDomain:
                     nrpspksdomains_IE325_RS32285_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.5"
                     /locus_tag="IE325_RS32285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65250"
                     /product="thioesterase II family protein"
                     /protein_id="WP_190073654.1"
                     /sec_met_domain="Thioesterase (E-value: 9.8e-37, bitscore:
                     121.3, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-09, bitscore:
                     32.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALVSADWLRPFPVPASDAPARLFCLPYAGGSCAAYRDWLRLRG
                     RVPDPRVEVIAVRLPGRGSRVREPAVEEVGALARELVEVMAPHLDRPYGIYGHSMGGII
                     GLALAEEIARTPGLRQPETLFTGAAVTPDAVRPQPEWRGTDAELTEWLRRTGGTPASVL
                     SSPALLSVLLPALRADLALVASSRGRPLTRLAVPVRGFAGADDRLTPARVMGGWAARTS
                     AGFTLSEVPGGHFFLPVSGPLVLDTIARALCDT"
     aSDomain        complement(2153..2800)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32285_Thioesterase.1"
                     /evalue="6.30E-38"
                     /label="IE325_RS32285_Thioesterase.1"
                     /locus_tag="IE325_RS32285"
                     /protein_end="238"
                     /protein_start="22"
                     /score="123.4"
                     /tool="antismash"
                     /translation="RLFCLPYAGGSCAAYRDWLRLRGRVPDPRVEVIAVRLPGRGSRVR
                     EPAVEEVGALARELVEVMAPHLDRPYGIYGHSMGGIIGLALAEEIARTPGLRQPETLFT
                     GAAVTPDAVRPQPEWRGTDAELTEWLRRTGGTPASVLSSPALLSVLLPALRADLALVAS
                     SRGRPLTRLAVPVRGFAGADDRLTPARVMGGWAARTSAGFTLSEVPGGHFFLP"
     CDS_motif       complement(2534..2599)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32285_0001"
                     /evalue="3.30E-06"
                     /label="NRPS-te1"
                     /locus_tag="IE325_RS32285"
                     /protein_end="111"
                     /protein_start="89"
                     /score="19.6"
                     /tool="antismash"
                     /translation="DRPYGIYGHSMGGIIGLALAEE"
     gene            complement(2863..3303)
                     /locus_tag="IE325_RS32290"
                     /old_locus_tag="GCM10018780_65260"
     CDS             complement(2863..3303)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139201.1"
                     /locus_tag="IE325_RS32290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65260"
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_190073655.1"
                     /transl_table=11
                     /translation="MTQALSTDLFAVGADLPEPPPRYVDRDTLAAFAEAYGDTNPIHLD
                     PEAARAAGLDDVIAHGMLSMALLGGLLAGWFPPGDILTFRASFVAAVPVPARLRCTARV
                     KALEETPTGQPAARLALAVRLVDGPLAVRGEALVRISRPGGV"
     gene            complement(3300..3737)
                     /locus_tag="IE325_RS32295"
                     /old_locus_tag="GCM10018780_65270"
     CDS             complement(3300..3737)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024844.5"
                     /locus_tag="IE325_RS32295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65270"
                     /product="MaoC family dehydratase N-terminal
                     domain-containing protein"
                     /protein_id="WP_190073656.1"
                     /transl_table=11
                     /translation="MIDRRFAGTDLVPYSVPVERDRLRRYAAAVGLPGPEFTDVTAARA
                     AGHRDLPVPPALLAGLERDEPGDFLAEMGVRLTDVRHVEQGFVHHAQVYAGDVLRFAPR
                     ITDVRSRGGMEFVARDTRVTRDGELVAELRQMILVLGGGAA"
     gene            complement(3734..5188)
                     /locus_tag="IE325_RS32300"
                     /old_locus_tag="GCM10018780_65280"
     CDS             complement(3734..5188)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (36-382). E-value: 7.1e-52.
                     Score: 168.3. Matches aSDomain:
                     nrpspksdomains_IE325_RS32300_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139199.1"
                     /locus_tag="IE325_RS32300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65280"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_190073657.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-38, bitscore:
                     125.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDARTETIVDGDTAPDFATWLARRLDGDGRDGELWAHGEREVTRG
                     RLREETARAESLLAAHGMGPGSTAAVQLPPSFTLLWSVFALWRMGAQVMLLDPRLTAAE
                     TSRLIEVCEPQFHLTSGQEPLRVAGFRDQCEVVVRRRPSGHAARTAHRLLQFSSGSTGL
                     PKVIGRTGESLLAEIGRFGRLDGMPRRGEGVLLLSSLVHSFGLIGGVLHALNAGSALHF
                     ARRPHRGELHQLLTERGLAAVFGVPAHFDLLSRNTGDDVPHGLRLAVSGGEIMPAEVYE
                     RFARRYGVRIGQAYGMTEVGIIATDLGGTVPPPAVGVPAPGIHVTVRDGTLRLSLPENP
                     YVYGEHTGRYTDGWLDTHDLCTTDPGTGALTITGRVDSVVAVGGLKVDLSEVESVLEAH
                     PAVTEAVVVYGEAIEAHVVLETRAGRVSSRDLVAWCRARLSPYKIPKAFHFPAALPRTS
                     NGKLIRNSELLHAARERVGRRKVATL"
     CDS_motif       complement(4010..4072)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32300_0001"
                     /evalue="1.90E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="IE325_RS32300"
                     /protein_end="393"
                     /protein_start="372"
                     /score="11.1"
                     /tool="antismash"
                     /translation="TGRVDSVVAVGGLKVDLSEVE"
     aSDomain        complement(4043..5080)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32300_AMP-binding.1"
                     /evalue="7.10E-52"
                     /label="IE325_RS32300_AMP-binding.1"
                     /locus_tag="IE325_RS32300"
                     /protein_end="382"
                     /protein_start="36"
                     /score="168.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HGEREVTRGRLREETARAESLLAAHGMGPGSTAAVQLPPSFTLLW
                     SVFALWRMGAQVMLLDPRLTAAETSRLIEVCEPQFHLTSGQEPLRVAGFRDQCEVVVRR
                     RPSGHAARTAHRLLQFSSGSTGLPKVIGRTGESLLAEIGRFGRLDGMPRRGEGVLLLSS
                     LVHSFGLIGGVLHALNAGSALHFARRPHRGELHQLLTERGLAAVFGVPAHFDLLSRNTG
                     DDVPHGLRLAVSGGEIMPAEVYERFARRYGVRIGQAYGMTEVGIIATDLGGTVPPPAVG
                     VPAPGIHVTVRDGTLRLSLPENPYVYGEHTGRYTDGWLDTHDLCTTDPGTGALTITGRV
                     DSVVAV"
     gene            complement(5206..6324)
                     /locus_tag="IE325_RS32305"
                     /old_locus_tag="GCM10018780_65290"
     CDS             complement(5206..6324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139198.1"
                     /locus_tag="IE325_RS32305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65290"
                     /product="3-dehydroquinate synthase II"
                     /protein_id="WP_190073658.1"
                     /transl_table=11
                     /translation="MKFAWIDIRSVDAGQREGVVDAAIHAGLAGFVDDRPDVLATLPPT
                     VRKVLVADPDGTVDPEVADLVDVVLTPVRTTAELDKLRLVAAEDPKRGGALVDVVDDPT
                     LRLACAAAQDLEHTVVSFRDPTKIPLEIVIAAADKTPGKLICQAADLEEAGIIVDVLEK
                     GSDGLLFAPKDANGVFGLSELLRTSTPDLDLTTLTVESIEHNGLGDRVCVDTCTHFEKD
                     EGILVGSYAHGFVLCVSETHPLPYMPTRPFRVNAGALHSYVLGADNRTNYLSELKAGST
                     VLGVTADGRTRRIVVGRVKLESRPLLTVRARSEEGVEVSLTLQDDWHVRILGPGAAVLN
                     CTELKPGDKLLGYIATDKRHVGWPVGEFCIEK"
     gene            6671..7492
                     /locus_tag="IE325_RS32310"
                     /old_locus_tag="GCM10018780_65300"
     CDS             6671..7492
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139185.1"
                     /locus_tag="IE325_RS32310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65300"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_190073659.1"
                     /transl_table=11
                     /translation="MTPKSGGLAVRLARLSRHRAGRHLFVPLDHSVADGPIVAAGRFNT
                     LVRMAVTGGADAIVVHKGRAATVDPLLLRDCSLIVHLSASTAHAADADAKVLVGDVEEA
                     IQLGADAVSVHVNIGSDTESRQLADLGTVADTARRWGVPLLAMVYPRGPRISDPHNPAL
                     LSHVVNVAADLGASLAKTTWAEPLERMADVVESCPIPVLVAGGPSRSDAGLAAYARGAV
                     AAGCSGLAVGRNFFESSSPAAVIRTLSAVVHGTTQSAPAGALGAAEPVPAT"
     gene            7552..7830
                     /locus_tag="IE325_RS32315"
                     /old_locus_tag="GCM10018780_65310"
     CDS             7552..7830
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (7-76). E-value: 1.4e-10.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_IE325_RS32315_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139186.1"
                     /locus_tag="IE325_RS32315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65310"
                     /product="acyl carrier protein"
                     /protein_id="WP_190073660.1"
                     /sec_met_domain="PP-binding (E-value: 7e-11, bitscore:
                     36.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHEETREFILTVVRDVINLPVPERVDDALPLGEEGLGLESLAMIE
                     LVLQLEGEYGIELPEEELEPELVPDLGAFVRAVVDRRTRLAAGSPAK"
     aSDomain        7573..7779
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32315_PP-binding.1"
                     /evalue="1.40E-10"
                     /label="IE325_RS32315_PP-binding.1"
                     /locus_tag="IE325_RS32315"
                     /protein_end="76"
                     /protein_start="7"
                     /score="33.3"
                     /tool="antismash"
                     /translation="FILTVVRDVINLPVPERVDDALPLGEEGLGLESLAMIELVLQLEG
                     EYGIELPEEELEPELVPDLGAFVR"
     gene            7827..8081
                     /locus_tag="IE325_RS32320"
                     /old_locus_tag="GCM10018780_65320"
     CDS             7827..8081
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE325_RS32320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018780_65320"
                     /product="hypothetical protein"
                     /protein_id="WP_190073661.1"
                     /sec_met_domain="PP-binding (E-value: 3.7e-07, bitscore:
                     24.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITDDEVAGLLRESGQLLEEWDSDTELSLDSLTFVWLVHLLEERH
                     GIVVGPDDEEELAASDTIGALRGNLDRLIRDTEGARHGG"
     gene            8071..9306
                     /locus_tag="IE325_RS32325"
                     /old_locus_tag="GCM10018780_65330"
     CDS             8071..9306
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (82-400). E-value:
                     9.9e-45. Score: 145.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS32325_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174209.1"
                     /locus_tag="IE325_RS32325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65330"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_190073662.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.3e-21, bitscore:
                     70.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2fas (E-value: 3.1e-86, bitscore: 283.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAESTTSDVVVITGFGVVTAFGFGADAVRDGVFGGRPGFVPVSR
                     FDVTPFHAKKAATYEGGGPRIPGVPVKPGYTPTQAEVLYACTAEALRMAGTDAAGAPVL
                     IGTNGDHSASRSFWTDQAEGRGPEDPRTLDSMPGRLAETLGTAFGLGRPRLAFVNACVA
                     STNAIAHGAALIRRGLADTVVCGGAYLVTEDVFAKFDSGKALSREGVVRPFSAGRAGLL
                     QGDGGAVLVLESARRARARGAEPLAEVAGWGMAADAYHVIKPHPRGAGLARAADTALRR
                     AGLTPERIGYVNAHGTGTPLNDVAETAALHRIFGAHEPQVPVSSTKSSTGHMLEATGAV
                     EAVITLLALRDGVLPPTIGFRERDPGCDLDYVPGEARPSRATHALSLNAAFGGVNAALV
                     LSLPGNSRRDGA"
     aSDomain        8317..9270
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32325_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.90E-45"
                     /label="IE325_RS32325_PKS_KS.1"
                     /locus_tag="IE325_RS32325"
                     /protein_end="400"
                     /protein_start="82"
                     /score="145.1"
                     /tool="antismash"
                     /translation="LYACTAEALRMAGTDAAGAPVLIGTNGDHSASRSFWTDQAEGRGP
                     EDPRTLDSMPGRLAETLGTAFGLGRPRLAFVNACVASTNAIAHGAALIRRGLADTVVCG
                     GAYLVTEDVFAKFDSGKALSREGVVRPFSAGRAGLLQGDGGAVLVLESARRARARGAEP
                     LAEVAGWGMAADAYHVIKPHPRGAGLARAADTALRRAGLTPERIGYVNAHGTGTPLNDV
                     AETAALHRIFGAHEPQVPVSSTKSSTGHMLEATGAVEAVITLLALRDGVLPPTIGFRER
                     DPGCDLDYVPGEARPSRATHALSLNAAFGGVNAALVL"
     CDS_motif       8941..8988
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32325_0001"
                     /evalue="7.20E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE325_RS32325"
                     /protein_end="306"
                     /protein_start="290"
                     /score="9.3"
                     /tool="antismash"
                     /translation="YVNAHGTGTPLNDVAE"
     gene            9303..9995
                     /locus_tag="IE325_RS32330"
                     /old_locus_tag="GCM10018780_65340"
     CDS             9303..9995
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ketoacyl-synt_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891004.1"
                     /locus_tag="IE325_RS32330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65340"
                     /product="beta-ketoacyl synthase chain length factor"
                     /protein_id="WP_190073663.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.5e-06, bitscore:
                     20.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="Ketoacyl-synt_2 (E-value: 2.5e-10,
                     bitscore: 34.4, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSLVAAGACRVPWGPAADGLPGAAPAELPGLTGFVLSRFNPLI
                     ADVVVDCLGEPGSPHDLTTGRADRTAIVLATTYGDTTTSDVATQRLVAGQVHSPLLFFQ
                     SVTTSVLGHLARQYGITGPISCISTGADPAAEALTLADLLLAEDDADQVLVVGVETAAN
                     ERVDWIHERVDEQGGFGPLPYGDAAVALLLRRGGEGTAAPKSRSWPQYGWLAPLVQLIT
                     DHDLRSSK"
     gene            10001..11107
                     /locus_tag="IE325_RS32335"
                     /old_locus_tag="GCM10018780_65350"
     CDS             10001..11107
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     mmyO"
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139182.1"
                     /locus_tag="IE325_RS32335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65350"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_229912176.1"
                     /sec_met_domain="mmyO (E-value: 1.5e-200, bitscore: 659.9,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFGAFLSPLHPLGEDPALSLWRDLELAEWLDRLGYDELWVGEHH
                     SAGWGTVSSPELFLATAAERTRHIRLGTGVVSLPYHHPFMVASRAVQLGHLTRGRFTLG
                     VGAGSIPSDMHFLGIDPADTRRRTAESLDVIMRLLEGSEPVTHRTDWFELRDARLQLRP
                     RGALPVAVSSATSPFGMRLAGQYGISPLSFGMPPRPGSQIGDLVGQWQHAQESAEEHGR
                     TLDRADWRVTLAVHVSESRGRALDEIVEGWQRYRNGYWSLVGAPPVHSRADAVKALEEA
                     IDRRGVIVGSPEECVEAIRDIQEITGGFGHLLVTVMDWADREPMKRSFEYLARFVAPHF
                     TGALKGVTDSYDWTSEQAARALAAMRQQ"
     gene            complement(11163..11885)
                     /gene="fabG"
                     /locus_tag="IE325_RS32340"
                     /old_locus_tag="GCM10018780_65360"
     CDS             complement(11163..11885)
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-172). E-value: 2e-19. Score:
                     62.2. Matches aSDomain:
                     nrpspksdomains_IE325_RS32340_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602545.1"
                     /locus_tag="IE325_RS32340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65360"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_190073665.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-37, bitscore:
                     122.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 1.8e-30, bitscore:
                     100.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTARQARSVLVTGGNRGIGLAVARAFAAQGDKVAVTHRGSGAP
                     EGMLGVKCDVTDADQVARAFDEVEAAQGPVDVLVSNAGVTDDKLLPRMSDPQFFQVLDT
                     NLGGAFRTARRASAGMLRRRAGRIVFVSSVAALRGSLGQTNYAASKAGIVGLARSLARE
                     LGSRGVTVNVVAPGLVATDMTAQLPDRTRARMTEDIPLGRVADPAEVASAVLWLASPGA
                     SYVTGAVVPVDGGLGMGH"
     CDS_motif       complement(11175..11243)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32340_0003"
                     /evalue="1.80E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE325_RS32340"
                     /protein_end="237"
                     /protein_start="214"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="LWLASPGASYVTGAVVPVDGGLG"
     aSDomain        complement(11370..11858)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32340_PKS_KR.1"
                     /evalue="2.00E-19"
                     /label="IE325_RS32340_PKS_KR.1"
                     /locus_tag="IE325_RS32340"
                     /protein_end="172"
                     /protein_start="9"
                     /score="62.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAVARAFAAQGDKVAVTHRGSGAPEGMLGVKCD
                     VTDADQVARAFDEVEAAQGPVDVLVSNAGVTDDKLLPRMSDPQFFQVLDTNLGGAFRTA
                     RRASAGMLRRRAGRIVFVSSVAALRGSLGQTNYAASKAGIVGLARSLARELGSRGVTVN
                     "
     CDS_motif       complement(11442..11501)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32340_0002"
                     /evalue="3.70E-07"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE325_RS32340"
                     /protein_end="148"
                     /protein_start="128"
                     /score="22.7"
                     /tool="antismash"
                     /translation="VFVSSVAALRGSLGQTNYAA"
     CDS_motif       complement(11784..11858)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32340_0001"
                     /evalue="1.00E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE325_RS32340"
                     /protein_end="34"
                     /protein_start="9"
                     /score="24.6"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAVARAFAAQGDK"
     gene            complement(11913..12422)
                     /locus_tag="IE325_RS32345"
                     /old_locus_tag="GCM10018780_65370"
     CDS             complement(11913..12422)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.5"
                     /locus_tag="IE325_RS32345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65370"
                     /product="flavin reductase family protein"
                     /protein_id="WP_190073666.1"
                     /transl_table=11
                     /translation="MVSTQAAPPDPRAFREAMGHFPTGIAVITVGHGAGTEAMTASSIA
                     SISLEPTLVLVSVNNGGRLVPAIDAAGGFAVNVLAQDQGELSRRFAARDRPGGLVAERL
                     LGGTTGPGGHLLVPDALVSLECTTAHRYPAGDHLLYLGRVETLGVAEEVRPPLVHHRGS
                     YARLSA"
     gene            complement(12447..12914)
                     /locus_tag="IE325_RS32350"
                     /old_locus_tag="GCM10018780_65380"
     CDS             complement(12447..12914)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891002.1"
                     /locus_tag="IE325_RS32350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65380"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_190073667.1"
                     /transl_table=11
                     /translation="MGSKSPTADARPDGDGVAPEVPDRNVIVAPPSLAGEQLATRMGIE
                     VVSAEPERVVATMPVSGNMQPFGWLHGGANAVLAETLGSVAAGLWVAPRGAVAGLELSC
                     THHRSARSGRVTGVCTPLHLGSRVATYQIEITDDKGRPTCTARLTCLVHKR"
     gene            complement(13102..13716)
                     /locus_tag="IE325_RS32355"
                     /old_locus_tag="GCM10018780_65390"
     CDS             complement(13102..13716)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139176.1"
                     /locus_tag="IE325_RS32355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65390"
                     /product="TetR-like C-terminal domain-containing protein"
                     /protein_id="WP_190073668.1"
                     /transl_table=11
                     /translation="MADTTPEGPEAAGKRTDPRVLRTRALLRAAALELAAERELATITI
                     ANVAERATVNRATVYQHYPDLDALMLDSMEDQLAKLVGLAADCPLVVLPDAMPDEFVQV
                     FRHVEADATLYRRMLGPCGSARFVNRLRQLLAEQVARQLAQAGAGSPDDIGVELRAHCS
                     AGAFIGLISCWLLHPRPLRAEQAAEHAWGGLHLVSSRPAQV"
     gene            complement(13735..14454)
                     /locus_tag="IE325_RS46305"
                     /old_locus_tag="GCM10018780_65400"
     CDS             complement(13735..14454)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="IE325_RS46305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65400"
                     /product="response regulator transcription factor"
                     /protein_id="WP_229912147.1"
                     /transl_table=11
                     /translation="MFTRPDESSLKIALILENEVSRYGVEGMLRRLGSVHSVLSFNTGD
                     EALASCGADAFDLVVVSGAELAATQNLAATEGLSARDVRLLLLVDAADGVDLPQSAHSC
                     VHALVDWAGLTPEVFADAVSDVMAGKFYVSATLARRVLRQTGPAAAEARPWGAPGTMLT
                     PRELEVLHLVAEGLSNKQAARRLQISEHGVKRLVGNVLAKLNCPNRTLAVVRAMEDGLL
                     TGLGRAMATPQSATRVA"
     gene            complement(14435..15166)
                     /locus_tag="IE325_RS32365"
                     /old_locus_tag="GCM10018780_65410"
     CDS             complement(14435..15166)
                     /NRPS_PKS="Domain: ACPS (113-173). E-value: 1.9e-10. Score:
                     32.6. Matches aSDomain:
                     nrpspksdomains_IE325_RS32365_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.5"
                     /locus_tag="IE325_RS32365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65410"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_190073669.1"
                     /transl_table=11
                     /translation="MTGTLTLWSGRSDGQSCAVDLDVLSAEEQRRFSAFHDPVRAAHFA
                     AAHAQVRRHLGRLLGMEPWEIRFARHPCAGCGRVRHGRPYIQYPETTWEFSLSRCGPRW
                     LCAAANGIRVGVDLERVRATDHGTLAAGVLSEHEREHLRGAARESRNTEFMRCWTRKEA
                     VVKASGIGVEADLRTVGVQPWSRIAKVNHRVPGHDIGAWLVLDLPPVEDYCSAFAVQST
                     PQSIQELSLLFGGEESVHPTG"
     aSDomain        complement(14648..14827)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32365_ACPS.1"
                     /evalue="1.90E-10"
                     /label="IE325_RS32365_ACPS.1"
                     /locus_tag="IE325_RS32365"
                     /protein_end="173"
                     /protein_start="113"
                     /score="32.6"
                     /tool="antismash"
                     /translation="VGVDLERVRATDHGTLAAGVLSEHEREHLRGAARESRNTEFMRCW
                     TRKEAVVKASGIGVE"
     misc_feature    15202..15222
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.55"
                     /tool="antismash"
     misc_feature    15324..15340
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.58"
                     /tool="antismash"
     misc_feature    15329..15343
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.6"
                     /tool="antismash"
     gene            15514..16698
                     /locus_tag="IE325_RS32370"
                     /old_locus_tag="GCM10018780_65430"
     CDS             15514..16698
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006139178.1"
                     /locus_tag="IE325_RS32370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65430"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_229912149.1"
                     /transl_table=11
                     /translation="MSTQSPPGPDIEADVCVVGSGATALFAALLCARHGHTVVLASPQE
                     EFEPAGAGISPLLAPPTLQLLAEQGVEEELIRDGRRVLGVDDHGTTGLLSRWRYTDHPG
                     IARPHGLTVTTGTLVQALLARLRDEPGVRVHTGVSVTALTQDDDGVRLTTTGGAIRAAY
                     AVAADGRASALRELTGIGLDVRTFDRPAWLVVTPDVPGRDPVLLVRHQAPAALFTIPIP
                     PESLAVVWSPDRDQEEALEQGGPAALAEQLRSVDPELADWLERSRDRVSPLIRLAFSLW
                     RADRWRAGRVLVLGESAHGLHTLGGQGLNQSLQDGASLARAVHDTLTTGDGTRVDDYER
                     IRRPHVEKLQDFQWNLQPLRSYSPAPPTRGAHEDFIEAMTRLDPALAGQLAASG"
     gene            complement(16771..18285)
                     /locus_tag="IE325_RS32375"
                     /old_locus_tag="GCM10018780_65440"
     CDS             complement(16771..18285)
                     /NRPS_PKS="Domain: AMP-binding (10-402). E-value: 2.3e-108.
                     Score: 354.4. Matches aSDomain:
                     nrpspksdomains_IE325_RS32375_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487279.1"
                     /locus_tag="IE325_RS32375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65440"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_190073671.1"
                     /sec_met_domain="AMP-binding (E-value: 4.2e-117, bitscore:
                     385.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSVASVLAESAWRRPDHTALVHGAERVTYAELWLRARRYAAAL
                     RGRGVRAGDRVAVLVPNGLDFPAVYYGALALGAVVVPVNALLKAPEIEQVLRDCGARLL
                     ACAPSLHGTGGPAAGAAGVPLFEVGEAGVAGVEPIERLVPTRPDDIALVLYTSGTTGRA
                     KGAMLTHFNVTMNIQTGMESPFAFRPDDVLLGCLPLFHTFGQICGMGTCFRAGATMVLM
                     DRFEGAGALDLMVRHGCTVVMGVPTMYLALLDAARSDPRRPELNRAYSGGSALSVATLD
                     EFEAVFGCPVYEGYGLTETSPCVSYNQPGMPRRPGKVGRPLWGVEVEIARQDLEGRIEL
                     LPAGEVGEVVIRGHNVMAGYLGRPEATAEVLVDGWFRSGDLGALDADGALTLVGRKKEL
                     VIRGGYNVYPREVEDVLAHHPAVAQAAVIGVPDARHGEEVCAVVRVREGYVASDRLAGE
                     IREWGRERLAAYKYPRRIEFVTDFPLGPSGKILKRELLGRYAAAVR"
     CDS_motif       complement(17047..17109)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0006"
                     /evalue="6.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="IE325_RS32375"
                     /protein_end="413"
                     /protein_start="392"
                     /score="12.5"
                     /tool="antismash"
                     /translation="VGRKKELVIRGGYNVYPREVE"
     aSDomain        complement(17080..18255)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32375_AMP-binding.1"
                     /evalue="2.30E-108"
                     /label="IE325_RS32375_AMP-binding.1"
                     /locus_tag="IE325_RS32375"
                     /protein_end="402"
                     /protein_start="10"
                     /score="354.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ESAWRRPDHTALVHGAERVTYAELWLRARRYAAALRGRGVRAGDR
                     VAVLVPNGLDFPAVYYGALALGAVVVPVNALLKAPEIEQVLRDCGARLLACAPSLHGTG
                     GPAAGAAGVPLFEVGEAGVAGVEPIERLVPTRPDDIALVLYTSGTTGRAKGAMLTHFNV
                     TMNIQTGMESPFAFRPDDVLLGCLPLFHTFGQICGMGTCFRAGATMVLMDRFEGAGALD
                     LMVRHGCTVVMGVPTMYLALLDAARSDPRRPELNRAYSGGSALSVATLDEFEAVFGCPV
                     YEGYGLTETSPCVSYNQPGMPRRPGKVGRPLWGVEVEIARQDLEGRIELLPAGEVGEVV
                     IRGHNVMAGYLGRPEATAEVLVDGWFRSGDLGALDADGALTLVGRKKELVIR"
     CDS_motif       complement(17176..17262)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0005"
                     /evalue="8.30E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="IE325_RS32375"
                     /protein_end="370"
                     /protein_start="341"
                     /score="34.1"
                     /tool="antismash"
                     /translation="PAGEVGEVVIRGHNVMAGYLGRPEATAEV"
     CDS_motif       complement(17617..17652)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0004"
                     /evalue="1.60E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="IE325_RS32375"
                     /protein_end="223"
                     /protein_start="211"
                     /score="3.1"
                     /tool="antismash"
                     /translation="CFRAGATMVLMD"
     CDS_motif       complement(17776..17835)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0003"
                     /evalue="1.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IE325_RS32375"
                     /protein_end="170"
                     /protein_start="150"
                     /score="24.0"
                     /tool="antismash"
                     /translation="ALVLYTSGTTGRAKGAMLTH"
     CDS_motif       complement(17911..17934)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0002"
                     /evalue="7.60E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="IE325_RS32375"
                     /protein_end="125"
                     /protein_start="117"
                     /score="1.0"
                     /tool="antismash"
                     /translation="AGAAGVPL"
     CDS_motif       complement(18037..18072)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS32375_0001"
                     /evalue="3.80E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="IE325_RS32375"
                     /protein_end="83"
                     /protein_start="71"
                     /score="1.9"
                     /tool="antismash"
                     /translation="GALALGAVVVPV"
     gene            complement(18372..19586)
                     /gene="hemA"
                     /locus_tag="IE325_RS32380"
                     /old_locus_tag="GCM10018780_65450"
     CDS             complement(18372..19586)
                     /EC_number="2.3.1.37"
                     /GO_function="GO:0003870 - 5-aminolevulinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (49-391). E-value: 3e-77.
                     Score: 252.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS32380_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="hemA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566618.1"
                     /locus_tag="IE325_RS32380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_65450"
                     /product="5-aminolevulinate synthase"
                     /protein_id="WP_190073672.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-76, bitscore:
                     252.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQHVELFRQEMEGFAPHQRQFLEIGRRAGRFPSAVARQGSERTD
                     AEISVWCSNDYLGMGQHPSVLSAMKEAIDTYGAGSGGSRNIGGTNHNHVLLEKELAAFH
                     GKEAGLLFSSGYTANDGALSVLAGRLPGTIVYSDALNHASIIDGLRHSGAQKRIFRHND
                     TAHLQELIAADPADRPKLIVLESVYSMSGDVAPLAEIADIAERYGASTFLDEVHAVGMY
                     GPEGAGIAAREGIADRFTVIMGTLAKGFGTAGGYIAGPAALVDAVRAFSRSFIFTTSLP
                     PATAAGALAAVRHLRSSEVERERLGANARLLHRLFDERGIPYISPMSHIVSAFVGDDAR
                     CREASALLLERHGIYVQAINAPSVREGEEILRIAPSATHTSQDVEKFADALDGIWQELD
                     IPRTS"
     aSDomain        complement(18414..19439)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS32380_Aminotran_1_2.1"
                     /evalue="3.00E-77"
                     /label="IE325_RS32380_Aminotran_1_2.1"
                     /locus_tag="IE325_RS32380"
                     /protein_end="391"
                     /protein_start="49"
                     /score="252.1"
                     /tool="antismash"
                     /translation="VWCSNDYLGMGQHPSVLSAMKEAIDTYGAGSGGSRNIGGTNHNHV
                     LLEKELAAFHGKEAGLLFSSGYTANDGALSVLAGRLPGTIVYSDALNHASIIDGLRHSG
                     AQKRIFRHNDTAHLQELIAADPADRPKLIVLESVYSMSGDVAPLAEIADIAERYGASTF
                     LDEVHAVGMYGPEGAGIAAREGIADRFTVIMGTLAKGFGTAGGYIAGPAALVDAVRAFS
                     RSFIFTTSLPPATAAGALAAVRHLRSSEVERERLGANARLLHRLFDERGIPYISPMSHI
                     VSAFVGDDARCREASALLLERHGIYVQAINAPSVREGEEILRIAPSATHTSQDVEKFAD
                     AL"
     misc_feature    20614..20628
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    20887..20901
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.8"
                     /tool="antismash"
ORIGIN
        1 gaacagcggg gtggactcca ggcagttgcc gccgcgccgc tcccggacca gcttcctgaa
       61 cagggtctcg tggtcgagga ccggcggtgt cccgtcgaag acgtcgagca tctcgtaggg
      121 gacggaccgc agatgcgcgg tgtacagctc gcgcaggcat tccagcgtcg gctcggtccg
      181 gcccgagtgg ccgatgcggt ccaggtactc ccgccacggc agtgccacgg tctccacgac
      241 ttcctccccg ttcctcgccg tttccggctc tcggactggg atcgattctg cgggcccgca
      301 ccggtcctga gcaggctcga ccgccctgct cgaaagggca ccccgacaag cgctccgctg
      361 gaagggccgt gatgggttgt tcttcgtctg cggcagcgtc gtggctggtc gcgcagttcc
      421 ccgcgcccct tcagggcgct gccctcgccg gcgtatgcca aagagccggg gggaccggta
      481 tatggggggt gtcagccggc gccgaccacc gactcgctct ccttctcctc ccggggtgcc
      541 tgtcgcgttg ccgccgtcct gcggggcagc agcaggcacg ggatcacggc cagtgccgtg
      601 aagaccaggg cccaccagaa cggcggcccg aaggacgtgg cgatgtcctt ggccaagtcg
      661 ccgcccggct ggatctgggt cacggcggcg gggccgcccg ccggcagccg gtcctcgatg
      721 tgctgctgga gcaccacggc caggaccgcc gtgccgatgg aggcggccac ccgctggaag
      781 acgttgaagg tgctggtcgc catcggggcc agttccttcg gcgcgctgct gaaggcgagg
      841 gtcatggtcg gcagcatggc gacaccgaga ccgaagccgc gcacgatcat cgcgacgccg
      901 agcagcacgg ggttgggatc ggcgtcgatg agcccgtacg gcacggtcgc cacgacggcg
      961 aggacgacgc cgaggacggt gaggttgcgc accccgagca ccgcggtgag ctggttgatc
     1021 aggatcacgc cggcgaagta gccgatgctc tgcgggagca gcagtagcgc ggactcggtc
     1081 accgtcgccc cgtgcaccag ctggaagtac atcggcagcg ggatcatcac gccgtacatc
     1141 gcgatgctca gcaggaggtt ggcgagggtg ccgttgcgga acgccggacg ggtgaacagg
     1201 cgcaggtcca ccaggggttc gaggcggctg cgcagggtgt agagggcgaa ggcggccagc
     1261 aggacgacgc cgatcaccag gccggcgacg gtcttgccgc cggtgaagcc gcccttgttg
     1321 ccggcctcgg acaggccgta gaggaacgcg gtcaggccgg gcatgaggag gatcaggccg
     1381 atcacgtcga gccgggcgtc cttggtgggc tccacgacgt tcttcacctt cagcatggcc
     1441 aggacgatgg tggccaggca cagcgggacg ttgatgaaga acagccagcg ccagctgagg
     1501 tagtcgacca ggacaccgcc cagtgagggg gcgatgagcg gcgcgaacat ggccgggatc
     1561 gacacgatgc ccatcagccg ccccagtcgc tgcggccccg ccgcctgcgc gagcagcgcc
     1621 tgtccgacgg ggacggccat gccgccgccg atgccctgga gcagccggaa cacgatcagg
     1681 ctggtggtgt cccaggcgag gcccgcgagg acggagccga tcaggaagag cacctgggag
     1741 accagcacca tctgcttggc gccgaagcgt gcggaggccc agccgctgag cgggatggtg
     1801 gccgagaggg ccagcagata tcccgtgacc acccactgca ccgtggagat ctgcgagtcg
     1861 aacgtggtgg ccagggggcc gatggcgacg ttgatgatgg tgctgtccag caggctggcg
     1921 aagccgccca gcgccatgat gccgctcagc caccacaggt ccgaggtgat acggccggag
     1981 tcaccggtcg tggttggcgc ctgctctgta ctcacggctg ctcgttccct ccgtcgtcgg
     2041 tcacgcacac catgcttcca caacacatgt cgtctgcaca acagatgttg gatagagctc
     2101 acgtgtcgca gagtgcgcgg gcgatggtgt cgagcacgag agggccggag accggcagga
     2161 agaaatgacc gccgggcacc tcggagaggg tgaacccggc cgacgtacga gccgcccagc
     2221 cgcccatcac ccgcgccggc gtcagccggt cgtcggcacc cgcgaacccc cgtacgggaa
     2281 ccgcgagtcg ggtgaggggc cggccgcggc tgctcgccac cagggcgagg tcggcgcgca
     2341 gggcaggcag caggacggag agcagcgcgg gagaggacag caccgaggcc ggcgtaccgc
     2401 ccgtgcgccg cagccactcg gtgagctcgg cgtccgtgcc gcgccactcc ggctgcggac
     2461 gtaccgcgtc cggggtcacc gcggcacccg tgaacagcgt ctccggctgc cgcagccccg
     2521 gcgtgcgcgc gatctcctcc gccagcgcca ggccgatgat cccgcccatg ctgtgcccgt
     2581 agatcccgta cggccggtcc agatggggcg ccatcacctc caccagctcc cgcgccagcg
     2641 ccccgacctc ctcgacggcc ggctcccgga cccggctgcc gcgcccgggc agccgtacgg
     2701 cgatcacctc gacgcgcggg tcgggcaccc ggccccgcaa ccggagccag tcccggtagg
     2761 cggcgcaact ccctcccgcg tacggcagac agaagagccg ggccggtgcg tcggacgccg
     2821 ggaccgggaa gggacggagc cagtcggcgg agaccagagc cgtcacactc cacccggccg
     2881 ggatatccgc accaacgcct ccccgcgtac cgcgagcggc ccgtccacca ggcgtaccgc
     2941 cagggcgagc cgcgccgccg gttgcccggt gggggtctcc tccagggcct tcacccgcgc
     3001 cgtgcagcgc agccgtgccg ggaccggtac ggccgcgacg aaggacgcgc ggaaggtcag
     3061 gatgtccccg ggcgggaacc agcccgcgag gagcccgccg agcagggcca tggagagcat
     3121 gccgtgggcg atcacgtcgt cgaggcccgc cgcacgggcc gcctcggggt cgaggtggat
     3181 ggggttggtg tcgccgtacg cctccgcgaa ggcggcgagc gtgtcccggt cgacgtaccg
     3241 cggcggcggc tcgggcaggt cggcgccgac cgcgaacagg tcggtggaaa gggcctgggt
     3301 catgccgcgc cgcctcccag cacgaggatc atctggcgca gctccgccac cagttcgccg
     3361 tcccgggtga cccgggtgtc gcgcgccacg aactccatcc cgccgcgact gcgcacgtcc
     3421 gtgatgcgcg gggcgaagcg caggacgtcc cccgcgtaca cctgggcgtg atggacgaac
     3481 ccctgctcga catggcgcac atcggtgagc cgtacgccca tctcggcgag gaagtcgccg
     3541 ggttcgtcgc gttccaggcc cgccagcagc gcgggcggca ccgggaggtc ccggtggcct
     3601 gccgcgcgcg cggccgtcac gtcggtgaac tccgggccgg ggagcccgac cgccgccgcg
     3661 tagcgccgca gccggtcgcg ctccaccggc acgctgtagg gcaccaggtc ggtgcccgcg
     3721 aaccgccggt cgatcacagc gtggccacct tccgccggcc cacccgttcc cgggccgcgt
     3781 gcagcagctc gctgttgcgg atcagcttgc cgttggaggt gcgcggcagc gcggccggga
     3841 agtggaaggc cttcgggatc ttgtacgggc tgagccgggc ccggcaccag gccaccaggt
     3901 cccggctgga gacccggccc gcgcgggtct ccagcacgac atgcgcctcg atggcctcgc
     3961 cgtagacgac gaccgcctcg gtcaccgccg ggtgcgcctc caggaccgac tcgacctcgc
     4021 tcagatcgac cttcagtccg ccgaccgcga cgaccgagtc cacccggccg gtgatggtga
     4081 gcgctccggt gccggggtcc gtcgtgcaga ggtcgtgcgt gtccagccag ccgtccgtgt
     4141 accggccggt gtgctcgccg tacacatacg ggttctccgg cagcgacagc cgcagcgtgc
     4201 cgtcccggac ggtgacgtgg atgccgggcg cgggtacgcc cacggcgggc ggcggcacgg
     4261 tgccgcccag gtcggtcgcg atgatcccga cctccgtcat cccgtacgcc tgcccgatcc
     4321 gtacgccgta gcgccgggcg aaccgctcgt acacctcggc cggcatgatc tcgccgccgc
     4381 tgaccgcgag ccgcagcccg tggggcacgt cgtcgccggt gttgcggctc agcaggtcga
     4441 agtgggccgg cacgccgaag acggcggcga ggccgcgctc ggtcagcagc tggtgcagct
     4501 cgccccgatg cgggcggcgc gcgaagtgca gcgccgagcc cgcgttcaga gcgtgcagca
     4561 ccccgccgat cagaccgaag gagtgcacca gcgaactgag cagcagcaca ccctcgcccc
     4621 gccggggcat gccgtccagc cgcccgaagc ggccgatctc ggcgagcagt gactcgccgg
     4681 tgcggccgat caccttcggc agtccggtgg accccgagct gaactggagc agccggtgcg
     4741 ccgtgcgggc cgcgtgcccc gacgggcgtc ggcgcaccac cacctcgcac tggtcccgga
     4801 agccggccac ccgcagcggc tcctggcccg aggtgaggtg gaactgcggt tcgcacacct
     4861 cgatcagccg gctggtctcc gccgcggtca gccgcgggtc gagcagcatg acctgcgcgc
     4921 ccatccgcca cagggcgaac accgaccaca acagggtgaa actgggcggg agctggacgg
     4981 cggccgtgct gcccgggccc atcccgtgcg ccgcgagcag cgactcggcg cgcgcggtct
     5041 cctcacgcag ccggccgcgc gtcacctccc gctcgccgtg ggcccacagc tcgccgtccc
     5101 gcccgtcgcc gtccagtcgc cgggcgagcc acgtggcgaa atccggggcg gtgtcgccgt
     5161 ccacgatcgt ctctgttcgt gcatccatcg tgctcgcccc ccgtgtcact tctcgatgca
     5221 gaactcgccc acgggccagc cgacatggcg cttgtcggtg gcgatgtagc cgagcagctt
     5281 gtcgccgggc ttcagttcgg tgcagttcag gacggcggcg cccgggccga ggatccgcac
     5341 gtgccagtcg tcctggagcg tgaggctcac ctcgacgccc tcctccgagc gggcccggac
     5401 cgtcagcagc gggcgggact ccagcttcac ccggccgacc acgatccgcc gggtgcggcc
     5461 gtccgcggtc acaccgagga cggtggagcc cgccttcagc tcgctcaggt agttggtgcg
     5521 gttgtcggcg ccgaggacgt aactgtgcag cgcgccggcg ttcacccgga acggccgggt
     5581 cggcatgtag ggcagcgggt gggtctcgct cacgcacagc acgaagccgt gggcgtagga
     5641 gccgaccagg atgccctcgt ccttctcgaa gtgggtgcag gtgtcgacgc agacgcggtc
     5701 gccgaggccg ttgtgctcga tggactccac ggtcagcgtg gtcagatcca ggtcgggggt
     5761 ggaggtccgc agcaactcgc tgagcccgaa caccccgttg gcgtccttcg gcgcgaacag
     5821 cagcccgtcg gagcccttct ccaggacgtc gacgatgatg ccggcctcct ccaggtcggc
     5881 ggcctggcag atgagcttgc cgggcgtctt gtcggccgcc gcgatgacga tctccagcgg
     5941 gatcttggtc gggtcgcgga aggacacgac cgtgtgctcc aggtcctggg cggccgcgca
     6001 ggccagccgc agcgtcgggt cgtccacgac gtcgacgagg gcgccgcccc gcttcgggtc
     6061 ctcggccgcc accagcctca gcttgtccag ctcggcggtg gtccgcaccg gcgtcagcac
     6121 gacgtccacg aggtcggcga cctccgggtc caccgtgccg tccgggtccg ccaccagcac
     6181 cttccgcacc gtcggcggca gcgtggcgag cacgtcggga cgatcgtcga cgaacccggc
     6241 gaggccggcg tggatcgcgg cgtccacgac cccctcccgc tgtccggcgt cgacggaacg
     6301 gatgtcgatc caggcgaact tcacagtaac catccctgcc tcgagtgggc cctacgccta
     6361 cggatcacac cgtcgcagcg gcaccgggat caccgacagc cgcgaaaggg ctggtcgatg
     6421 ggcggctcgc cgggcggcac ggtgggcacg ccgaggggcg ggcccggccc cggccttcgg
     6481 gctggccgac cggctacctc gtccggcgcc ccgcggcgca ctcgcagagg cagtccgttc
     6541 gaggggtcgc tccccgcgcg gtcccggcga gactcggtca ccggatcagg ctgttcggca
     6601 ccgcgggccc gcccgggccc cgcacccgct cctgaccggc aattccggct ctttcacctg
     6661 ggggtgggtc atgacaccaa agtccggtgg actcgcggtc cgcctggcac ggctgtcccg
     6721 gcaccgcgcg ggacgccatc ttttcgtgcc gctggaccac tcggtggccg acggcccgat
     6781 cgtcgccgcc gggcggttca acacgctggt ccgcatggcc gtgacaggcg gcgcggacgc
     6841 catcgtcgtg cacaaggggc gggcggcgac cgtcgatccg ctcctgctgc gcgactgctc
     6901 gctcatcgtg catctgagcg ccagcaccgc ccacgccgcc gacgccgacg cgaaggtcct
     6961 ggtcggcgac gtcgaggagg cgatccagct cggcgcggac gccgtcagcg tccatgtcaa
     7021 catcggctcc gacaccgaga gccggcagct ggcggacctc ggcacggtgg ccgacaccgc
     7081 ccgccgctgg ggcgtaccgc tgctcgcgat ggtgtacccg cgcgggccgc ggatcagcga
     7141 tccgcacaac cccgcgctgc tctcccatgt cgtgaacgtg gcggccgacc tgggcgcctc
     7201 gctggccaag accacctggg ccgagcccct ggagcggatg gcggacgtcg tcgagagctg
     7261 ccccatcccg gtactggtgg cgggcgggcc gagccgcagc gacgccggcc tcgccgccta
     7321 cgcccgcggc gccgtcgcgg ccgggtgcag cgggctcgcc gtggggcgca acttcttcga
     7381 gagcagctcg cccgcggcgg tcatccgcac gctctcggcc gtggtgcacg gcaccacaca
     7441 gtccgccccc gccggggccc tcggcgccgc cgaaccggtc ccggccacct gaccatccac
     7501 ccggcacatc cggccgcgta agcgcgcgga cgacgactca cggagaacgc catgcatgag
     7561 gagacccgag agttcatcct gaccgtggtc agggacgtca tcaatctccc ggtgcccgag
     7621 cgggtcgacg acgccctccc gctcggcgag gagggcctgg gactcgaatc gctggccatg
     7681 atcgagctgg tcctccagtt ggagggcgaa tacggcatcg agctgcccga ggaggagctg
     7741 gagcccgaac tcgtcccgga tctcggcgcc ttcgtgcggg cggtcgtcga ccggcgtacg
     7801 cgcctcgcgg cggggagccc ggccaagtga tcacggacga cgaggtggcc gggctgctgc
     7861 gcgagagcgg ccagctgctc gaggagtggg actccgacac ggagctcagc ctcgactcgc
     7921 tgaccttcgt ctggctcgtc catctgctgg aggaacgcca cggcatcgtc gtgggcccgg
     7981 acgacgagga ggaactcgcc gccagcgaca ccatcggcgc gctgcgcggc aacctcgacc
     8041 ggctgatacg ggacacggag ggcgcgcggc atggtggctg agagcactac gtccgacgtg
     8101 gtggtgatca ccggcttcgg cgtggtcacc gccttcggct tcggcgcgga cgccgtgcgc
     8161 gacggggtct tcggcggacg gcccggcttc gtgccggtga gccgcttcga cgtgacgccg
     8221 ttccacgcga agaaggcggc gacgtacgag ggcgggggcc cgcggatccc cggcgtcccg
     8281 gtcaagccgg gctacacacc gacgcaggcg gaggtcctgt acgcctgcac ggccgaggca
     8341 ctgcgcatgg ccggcaccga cgcggccggc gcaccggtgc tgatcggcac caacggcgac
     8401 cacagtgcga gccgctcatt ctggaccgac caggccgagg gccggggccc cgaggacccg
     8461 cgcaccctgg acagcatgcc gggccgtctc gcggagacac tcggcaccgc gttcggtctg
     8521 ggccggccgc ggctggcgtt cgtcaacgcc tgtgtggcct cgaccaacgc catcgcgcac
     8581 ggcgccgcgc tgatccggcg cggcctcgcc gacaccgtgg tgtgcggcgg cgcctacctc
     8641 gtcaccgagg acgtcttcgc gaagttcgac tccggcaagg cactgagccg ggagggcgtc
     8701 gtacgcccct tctcggccgg ccgggccggg ctgctccagg gcgacggcgg ggcggtgctc
     8761 gtcctggagt cggcacggcg ggcccgcgcc cgcggggctg agccgctcgc cgaggtggcg
     8821 ggctggggca tggcggccga cgcgtaccac gtcatcaagc cgcatccgcg gggagcgggc
     8881 ctggcacgcg ccgccgacac cgcgctgcgc cgggccggtc tcacccccga gcggatcggc
     8941 tacgtcaacg cgcacggcac cggcaccccg ctcaacgacg tcgcggagac cgcggccctg
     9001 caccggatct tcggcgccca cgaaccgcag gtcccggtga gctccaccaa gagcagcacc
     9061 ggccacatgc tggaggccac cggcgcggtg gaggcggtca tcaccctgct cgcgctgcgc
     9121 gacggggtgc tgccgccgac gatcggcttc cgcgagcggg accccggctg cgatctggac
     9181 tacgtgcccg gcgaggcccg cccgtcccgt gccacccacg ccctgtcgct caacgcggcc
     9241 ttcggcgggg tgaacgcggc gctcgtgctg agcctgccgg ggaactcccg aagggacggc
     9301 gcatgaccac ctcactcgta gcggcggggg cctgccgggt gccctggggg ccggccgcag
     9361 acggcctgcc cggcgccgcg cccgccgaac tgcccggtct gacgggcttc gtcctgtccc
     9421 ggttcaaccc gctgatcgcc gacgtagtcg tggactgcct cggcgagccg ggctcaccgc
     9481 acgacctgac cacgggccgc gccgaccgca ccgccatcgt gctcgccacg acctacggcg
     9541 acaccacgac atccgacgtg gccacccagc ggctggtggc cggccaggtg cacagcccgc
     9601 tgctgttctt ccagtcggtg accacgtccg tcctcggcca tctggccagg cagtacggca
     9661 tcaccggacc gatcagctgc atctcgaccg gcgccgaccc ggccgccgag gcactgaccc
     9721 tggccgatct gctgctggcg gaggacgacg cggaccaggt gctggtcgtc ggcgtcgaga
     9781 cggcggccaa cgagcgcgtc gactggatcc acgaacgggt cgacgagcag ggcgggttcg
     9841 ggccgctgcc gtacggcgac gcggcggtgg cgctgctgct gcgccgcggc ggggagggga
     9901 cggcggcccc gaagtcgcgc tcatggccgc agtacggctg gctggccccg ctcgtacagc
     9961 tgatcaccga ccacgacctg aggagcagca agtgaaccgg atgggctttg gcgccttcct
    10021 ctcccccctc cacccgctcg gcgaggaccc cgcgctgtcc ctgtggcgcg acctcgaact
    10081 cgccgagtgg ctcgaccgcc tcggctacga cgaactctgg gtcggcgagc accactccgc
    10141 cggctggggc accgtcagct cccccgagct gttcctcgcc accgcggccg agcggacccg
    10201 gcacatccgg ctgggcacgg gtgtggtgag cctgccgtac caccacccct tcatggtggc
    10261 gtcgcgggcc gtgcagctgg gccacctgac gcggggccgt ttcaccctgg gcgtcggggc
    10321 cggttcgatc ccctccgaca tgcacttcct cggcatcgac ccggccgaca cccggcgtcg
    10381 taccgccgag tccctggacg tgatcatgcg cctgctggag ggctccgagc cggtcacgca
    10441 ccgtacggac tggttcgaac tgcgcgacgc gcggctgcag ttgcggcccc ggggtgctct
    10501 tcccgtcgcc gtgtccagcg cgacctcgcc gttcgggatg cgcctcgccg ggcagtacgg
    10561 gatctcgccg ctctccttcg ggatgccgcc gcggcccggc agccagatcg gcgacctggt
    10621 cggccagtgg cagcacgcgc aggagtcggc cgaggagcac ggccgtacgc tcgaccgggc
    10681 cgactggcgg gtgacgctgg ccgtgcatgt gtcggagagc cgagggcggg ccctggacga
    10741 gatcgtcgag ggctggcagc gctaccgcaa cgggtactgg tccctggtgg gcgcgccgcc
    10801 cgtgcactcg cgcgccgacg ccgtgaaggc gttggaggag gccatcgacc ggcgcggggt
    10861 gatcgtgggg tcgcccgagg agtgcgtcga ggcgatccgc gacatccagg agatcacggg
    10921 cggcttcggc catctgctgg tcacggtcat ggactgggcc gaccgcgagc ccatgaagcg
    10981 cagcttcgaa tacctcgccc gcttcgtggc accccacttc acgggcgcgc tgaagggcgt
    11041 gaccgactcc tacgactgga cgtcggagca ggcggcacgg gcgctggcgg cgatgcggca
    11101 gcagtgaaca ggtgaggaag gggccgccgg gaagatcccg gcggcccctt ctcgtgcgcc
    11161 tctcagtgac ccatccccag tccgccgtcc accggcacca ccgcaccggt cacatacgac
    11221 gcccccgggg aggccagcca gagcaccgcg gaggccacct ccgccgggtc cgcgacccgg
    11281 cccaggggga tgtcctcggt catccgggcc cgcgtccggt cgggcagctg tgccgtcatg
    11341 tcggtggcca ccaggccggg ggcgacgaca ttgacggtga cgccccgtga gccgagttcg
    11401 cgggccaggg accgggcgag accgacgatg ccggccttgc tcgccgcgta gttggtctgg
    11461 cccagggaac cgcgcagcgc cgccaccgag gagacgaaca cgatccgtcc cgcgcgccgg
    11521 cgcagcatcc cggcggaggc gcggcgcgcg gtgcggaagg cgccgccgag gttggtgtcg
    11581 agcacctgga agaactgcgg gtcgctcatc ctcggcagca acttgtcgtc ggtgacccct
    11641 gcgttggaga ccagtacgtc caccggcccc tgcgccgcct ccacttcgtc gaacgcccgc
    11701 gccacctgat cggcgtcggt gacgtcgcac ttgacgccga gcatcccctc gggcgcgccc
    11761 gaaccgcggt gcgtcaccgc gaccttgtcg ccctgtgccg cgaacgcccg ggctacggcc
    11821 agtccgatgc cccggttgcc gccggtgacg aggaccgagc gtgcctgccg tgccgtatct
    11881 gtcatcacta atcccttcct ccacggccct cttcaggccg acagccgcgc ataggagccg
    11941 cggtggtgga ccagcggcgg acggacctcc tcggccacgc cgagcgtctc cacccggccg
    12001 aggtagagca gatggtcgcc ggccggatac cggtgcgcgg tggtgcactc cagggacacc
    12061 agcgcgtcgg gcacgagcag atgcccgccc ggaccggtgg tgccgcccag cagccgctcg
    12121 gccaccaggc cgccgggccg gtcgcgcgcc gcgaaccggc gggacaactc gccctggtcc
    12181 tgggccagta cgttcacggc gaagccgccg gccgcgtcga tggccgggac gagccgtccg
    12241 ccgttgttca cgctcaccag gacgagggtc ggttcgagag agatcgaggc gatcgagctc
    12301 gcggtcatcg cctcggtgcc ggcgccgtgt cctacggtga tcacggcgat gcccgtcggg
    12361 aagtggccca tggcctcccg gaacgcccgc gggtccggcg gtgccgcctg cgtggacacc
    12421 attgatccgc ctttcgtttc ggctcgtcag cgcttgtgga caagacacgt caggcgggcc
    12481 gtgcaggtgg gccgcccttt gtcgtcggtg atctcgatct ggtacgtcgc cacccggctg
    12541 cccagatgca ggggcgtgca gacgccggtg acccggccgg agcgcgccga cctgtggtgc
    12601 gtacaggaca gttcgagtcc cgcgacggct cctcgcggcg ccacccacag gccggccgcg
    12661 accgagccga gggtctccgc gaggacggcg ttggccccgc cgtgcagcca gccgaagggc
    12721 tgcatgttgc cgctcaccgg catggtcgcg accacccgct ccggctccgc ggagaccacc
    12781 tcgatcccca tacgggtggc cagttgctcg ccggccagcg agggcggggc gacgatgacg
    12841 ttgcggtcgg gcacctccgg cgccacgccg tctccgtccg gcctcgcgtc tgctgtcgga
    12901 ctcttgctcc ccatgggccc ctctccccgt gccgtggtgc gcggtggtgc gcatctccac
    12961 ggtcctcggg gcggcgtgaa cggccaagac tccaccgagc tgaccgttcg ggcaggccag
    13021 ggcggcggaa cggggaggtc ccggaacgcg gaacatcccg ccccggcgag cgggacggga
    13081 tgtacgggac gtgggccggg gctagacctg tgccggtctg ctgctgacca ggtgcagacc
    13141 gccccacgcg tgctcggccg cctgctcggc gcgcagcggt cgcggatgca gcagccagca
    13201 ggagatcagg ccgatgaagg cacccgccga gcagtgcgcc cgcagctcga cgccgatgtc
    13261 gtcggggctg ccggcgccgg cctgcgccag ctgtcgcgcg acctgttcgg cgagcagctg
    13321 gcgcagccgg ttcacgaagc gggccgaccc gcacgggccg agcatgcgcc ggtagagcgt
    13381 cgcgtccgcc tccacatgac ggaagacctg gacgaactcg tccggcatcg cgtcgggcag
    13441 gacgaccagc gggcagtccg ccgcgaggcc gaccagcttg gcgagctggt cctccatcga
    13501 gtcgagcatc agcgcgtcga ggtccgggta gtgctggtag accgtggcgc ggttgacggt
    13561 cgcccgctcg gccacgttgg cgatggtgat ggtcgcgagc tcacgctcgg cggcgagctc
    13621 cagtgccgcg gcccgcagca gtgcccgggt cctgaggact cggggatcgg tgcgcttgcc
    13681 ggcggcttcc gggccttccg gggtcgtatc agccattagc ccaggctata cccgttaggc
    13741 aacacgtgtc gccgactgcg gcgtggccat ggcccgcccc aggccggtga gcaggccgtc
    13801 ctccatggca cggacgacgg cgagcgtgcg gttggggcag ttcagcttgg cgagcacatt
    13861 gcccaccagg cgcttcaccc cgtgctcgga gatctgcagc cgccgggcgg cctgcttgtt
    13921 gctcaggccc tcggcgacca ggtgcagcac ctccagttca cggggcgtga gcatggtgcc
    13981 cggcgcgccc cagggccgtg cctcggccgc ggccggcccg gtctgccgca gcacccggcg
    14041 ggccagggtg gccgacacat agaacttgcc ggccatgacg tcggagacgg cgtcggcgaa
    14101 gacctccggg gtcagacccg cccagtcgac gagcgcgtgc acacaggagt gcgcgctctg
    14161 cggcagatcg accccgtcgg ctgcgtcgac gagaagcagc agccgtacgt cgcgggcgct
    14221 gagcccttcg gtggcggcca ggttctgggt ggcggcgagc tccgcgcccg agaccaccac
    14281 gaggtcgaag gcatcggcac cgcacgaggc gagggcctcg tcgccggtgt tgaagctcag
    14341 gacgctgtgg acgcttccga gacggcggag catgccctcg acgccgtacc tgctgacctc
    14401 gttctcgaga atcagcgcta ttttgaggct gctctcatcc ggtcgggtga acactttctt
    14461 ctcccccaaa aagaagtgac aattcttgta tggactgtgg tgtggactga acggcaaaag
    14521 ccgagcaata atcttcgaca ggtggcaggt cgagcaccag ccacgctccg atgtcatgac
    14581 ccggaacgcg atgattcact ttcgcgatcc gcgaccacgg ctgtacgccc accgtgcgca
    14641 ggtccgcctc gaccccgatc ccactcgcct tgaccacggc ttccttccgt gtccagcagc
    14701 gcatgaactc ggtgttccgg ctctcccgcg cggcgccgcg cagatgttcc cgctcgtgct
    14761 cgctcagtac cccggccgcg agcgtgccgt ggtccgtggc gcgcacgcgc tccagatcga
    14821 cgcccacccg gattccgttc gcggcggcgc acagccatcg cggaccgcat cgggacaggc
    14881 tgaactccca ggtcgtttcc ggatactgga tgtagggccg gccatggcgg acccggccgc
    14941 agccggcaca aggatgccgg gcgaacctga tctcccacgg ctccatgccg aggagccggc
    15001 ctaggtggcg ccgaacctga gcgtgcgcgg cggcgaagtg cgcggcgcgc accggatcat
    15061 ggaaagccga gaacctccgt tgctcctcgg ccgacaggac atccagatcc acggcgcacg
    15121 actggccgtc ggaccggccc gaccacaatg tcagggtgcc ggtcaccggc ggcgaaacgg
    15181 gctacttggc accgggaaaa cagagcgtcg ttctcacgag aattcctccc ccaccttttc
    15241 cctcacgttc agcgggccga ccggaatctg atcgtcatcg aaaagtctcg gcgccagccc
    15301 gagttccatg caacacgggg ccactgtaat ttttctgtag ttcccggaat ggagaattcc
    15361 cctgccgccc cgctcagggt gcccgttcgg ccacccgccg ggtggccccg tgggcagccg
    15421 gaagtcgccg tccctgcggg cacggcccgt ccgccctgcc gcgacgagga tgctgctgac
    15481 ccagtcggcg tgagcaggag gagaggaacc gagttgagca cccaatcccc gccgggaccg
    15541 gacatcgagg ccgacgtctg tgtggtcggc agtggcgcga cagcgctctt cgcggcgctg
    15601 ctgtgcgccc gccacggcca tacggtcgtg ctggcctcgc cgcaggagga gttcgagccg
    15661 gccggcgccg gcatctcacc gctcctcgcc ccgcccacgc tccagctcct cgcggagcag
    15721 ggcgtggagg aggagctgat ccgggacggc cggcgcgtcc tcggcgtgga cgaccacggc
    15781 accacgggcc tgctctcccg ctggcgctac accgaccacc ccggcatcgc ccgcccccat
    15841 ggcctgaccg tcaccaccgg caccctcgtc caggcactcc tggcccggct gcgcgacgag
    15901 cccggggtcc gcgtccacac cggcgtgagc gtcaccgcac tgacgcagga cgacgacggg
    15961 gtacggctga ccaccaccgg cggcgccatc cgtgccgcct acgccgtcgc cgcggacggc
    16021 cgggcctcgg cgctgcgcga gctgaccggc atcggcctcg acgtacgtac cttcgaccgc
    16081 cccgcgtggc tcgtggtcac gcccgacgtc ccgggccgcg accccgtcct cctcgtccgg
    16141 caccaggccc cggccgcgct gttcaccatc ccgatcccgc ccgagtccct cgccgtcgtc
    16201 tggtcgccgg accgggacca ggaggaggcg ctggagcagg gcggcccggc ggcgctggcc
    16261 gagcagctcc gctccgtgga cccggagctg gcggactggc tggagcggtc gcgggaccgg
    16321 gtgtcgcccc tgatccggct cgccttctcc ctctggcggg ccgaccgctg gcgggccggc
    16381 cgggtgctcg tgctcggcga gagcgcacac ggcctgcaca ccctgggcgg ccagggcctc
    16441 aaccagtcgc tccaggacgg cgcctcactg gcccgcgccg tccacgacac gctcaccacc
    16501 ggggacggca cccgcgtcga cgactacgag cgcatccgac ggccgcatgt ggagaagctc
    16561 caggacttcc agtggaacct ccagccgctg cgctcgtaca gcccggcccc gcccacgcgg
    16621 ggcgcgcacg aggacttcat cgaggcgatg acccgcctgg acccggccct ggccggacag
    16681 ttggcggcgt ccggctgatc cgggctccgc accccggcgg ggctccaggt gcgctgcgcg
    16741 cccggagccc cgctcgtcgt gtccggccgc tcaccgcacc gccgccgcat acctcccgag
    16801 cagctcccgt ttgaggatct tgccgctggg gccgaggggg aagtccgtca cgaactcgat
    16861 gcgccgcggg tacttgtacg ccgccagccg ctcccgcccc cactcccgga tctcaccggc
    16921 gaggcggtcc gaggcgacgt acccctcacg cacccggacc acagcgcaca cctcctcgcc
    16981 gtgccgggcg tccggcaccc cgatgacggc ggcctgcgcc acggcgggat ggtgggcgag
    17041 gacgtcctcg acctcacgcg gatacacgtt gtacccgccg cggatcacca gttccttctt
    17101 acggccgacc agggtgagcg ccccgtcggc gtccagcgcc ccgaggtcgc cggaccggaa
    17161 ccagccgtcg accagcacct ccgcggtcgc ctccggccgg ccgaggtacc cggccatcac
    17221 gttgtggcca cggatcacca cctcgcccac ctcccccgcg ggcagcagct cgatccgccc
    17281 ctccaggtcc tgccgggcga tctccacctc cacaccccac aggggccggc ccaccttgcc
    17341 cggcctgcgc ggcatgcccg gctggttgta cgagacgcaa ggggaggtct ccgtcagccc
    17401 gtacccctcg tagaccgggc acccgaagac cgcctcgaac tcgtcgagcg tcgccacgga
    17461 cagcgcggag cccccggagt aggcccggtt cagctccggt cgccgggggt cggagcgggc
    17521 ggcgtcgagg agcgcgaggt acatcgtcgg cacgcccatc acgacggtgc acccgtggcg
    17581 caccatcagg tccagcgcgc ccgccccctc gaaccggtcc atcagcacca tggtcgcccc
    17641 ggcccggaag caggtgccca tgccgcagat ctgcccgaag gtgtggaaca gcggcagaca
    17701 gccgagcagc acgtcgtccg gccggaaggc gaacggcgac tccatgccgg tctggatgtt
    17761 catggtcacg ttgaagtggg tgagcatcgc gcccttggcc cggcccgtgg tccccgaggt
    17821 gtacagcacg agggcgatgt cgtcgggccg ggtcggcacc agccgctcga tcggctcgac
    17881 gcccgccacg cccgcctcgc cgacctcgaa cagcgggacc ccggccgcgc ctgccgccgg
    17941 accgcccgtg ccgtgcagcg aaggggcgca ggccagcagc cgggcgccgc agtcgcgcag
    18001 cacctgctcg atctccggtg ccttgagcag cgcgttcacc ggaaccacga ccgcgcccag
    18061 cgcgagtgcg ccgtagtaca cggccgggaa gtccaggccg ttgggcacca gcacggcgac
    18121 ccggtcaccg gcgcgcacgc cccggccgcg caacgccgcc gcgtaccggc gcgcacgcag
    18181 ccacagctcg gcgtacgtca cccgctccgc gccgtggacc agcgccgtat ggtctggcct
    18241 gcgccacgcg gactcggcga gaaccgaggc tacggagaga gtcatgagac ctccgcggaa
    18301 ctgtcgtaaa cgaagggaag ggacaaagag cggtgacccg agacgaccca cggctccggc
    18361 caccgccccg ctcaggaggt ccgcggaatg tccagctcct gccagatgcc gtcgagggcg
    18421 tcggcgaact tctccacgtc ctgtgaggtg tgcgtcgcgg acggcgcgat gcgcaggatc
    18481 tcctcgccct ccctgacgct gggcgcgttg atggcctgga catagatgcc gtgccgctcc
    18541 agcagcagcg ccgaggcctc gcggcagcgt gcgtcgtcgc cgacgaacgc cgagacgatg
    18601 tgcgacatcg gcgagatgta cgggatgccc cgctcgtcga acagccggtg cagcagccgc
    18661 gcgttcgccc ccagccgctc ccgctccacc tcggacgagc gcagatggcg caccgcggcg
    18721 agggcgcccg ccgcggtggc cggcggcagc gaggtggtga agatgaacga acgcgagaag
    18781 gcgcgtacgg catccacgag agccgcggga ccggcgatgt aaccgccggc cgtgccgaag
    18841 cccttggcca gggtgcccat gatcacggtg aaccggtcgg ctatgccctc gcgtgcggcg
    18901 atgcccgcgc cctcggggcc gtacatgccg acggcgtgca cctcgtcgag gaaggtgctg
    18961 gcgccgtacc gctcggcgat gtcggcgatc tcggcgagcg gcgcgacgtc accggacatc
    19021 gagtacaccg actccaggac gatcagcttc ggccggtcgg ccgggtccgc cgcgatcagc
    19081 tcctggaggt gagccgtgtc gttgtgccgg aagatgcgct tctgggcgcc gctgtgccgc
    19141 agtccgtcga tgatcgaggc gtggttcagg gcgtccgagt agacgatcgt gccgggcaga
    19201 cgaccggcca gcaccgacag ggcgccgtcg ttggcggtgt agccggagct gaacagcagc
    19261 ccggcctcct tgccgtggaa cgcggcgagt tccttctcca gcagaacgtg gttgtggttg
    19321 gtcccgccga tgttgcggga gcctccggag ccggcgccgt aggtgtcgat ggcctccttc
    19381 atcgcggaga gcaccgacgg gtgctggccc atgccgaggt agtcgttgct gcaccacacg
    19441 ctgatctcgg cgtccgtgcg ctcgctcccc tgccgtgcga cggcgctcgg gaaccgcccc
    19501 gcgcgccggc cgatctccag gaactgccgc tgatgcgggg cgaatccctc catctcctgg
    19561 cggaagagct ccacatgctg attcatgacg tcaactcact ctctggtggt ggccgtacga
    19621 ccgtgagcac gaccgtgggc agatggcggg gtggtgcggg gcttgcgggg cgcgggcggc
    19681 atgccgagga gcgcgctcac ccggcgtggc gggtcgcgcg gcttcactcg tggtggcgcc
    19741 cgattcagcg cgtcctggcc ggcgcgaggg cgcgcagccg ttgtttgtcc ggtttgccgg
    19801 tggcgttgag cggcaactcg tcgagcacat ggacgacttc aggggcgtgc tgcggcgaca
    19861 gcgtcccggc gaccgcggcg cgcagcgcct cggtgtcgag ccgtgcgccg gggcgggcca
    19921 ccagcgcggc atggagatgc tcggcgccat ccgcgtcccg cacgccgaat acggcggcct
    19981 gtgcgaccgg cgcgagggcg aggatctccc gctccacgac cgccggatac accttcacgc
    20041 cctgcgtctt gacgacatcg gagaggcggt ccagcaggct cagatagccg cggtcgtcga
    20101 ggctgccgag gtcgccggtg cggtaccagc cgtcgcgcag cacctgggcc gtgagcccgg
    20161 gatcgttcca gtacccgtcc atgacgtgcg gcgagcgcat ccacacctca ccggtctccc
    20221 cgaccggctt ctcctgcccg gtgtccgggt cgcacacctt gatctcgacc tcggggaacg
    20281 gccggccgac ggtggagcgc agcgtctcgt cctggtgctc cccggggtcg agcagggtga
    20341 tgcggccgcc ctcgctggtc ccgtagccct ggacgagcgc gaacccgaag acgcgcaccg
    20401 cctcggcgat cctggcgggt gccgcggcgg agccgctgta gatcagcagc cgcagcgcgg
    20461 agaggtcggt ccggtcgatc cgctcgtggt cgagcagctg gtacaggtgc tgtgtggcca
    20521 cgaacgtcct ggtgatgcgg tgccgctcca gcgctctgag ggtggcgtcg ggctcggcct
    20581 cctccagcag gaccaccatg ccgccgcagg ccaggaccgc gtcggccatc ggccccacgg
    20641 tgtggctgag cggcgtggtg accagcatgc gcggctcggg ttcggtgacg gcggtcatcg
    20701 tcgcccgtac cgtgccctcc caggcccgcc ccgactgccg tattcctttg ggctgcccgg
    20761 tgcttccgct ggtgaaggcg atgatggcca gcgcctgcgg atcccacaca tcgggctgcc
    20821 cgtgctcggc ggcggcctgc ggcggctcgg caccgcgggt gattccggca cccggaaagc
    20881 ccgtgaggac gaagcggtcc ggggcgcgcc gggccagctc acgggcccgt tcggcgttct
    20941 ccgggtccgc gtggagcacg gacgccgacg tgtcgatcag catccgcagc tgggcgtccg
    21001 cggagagcat ccgggccgac gaaccggggt tggtggtccg cagatggcac acggcggcgc
    21061 cgagccggtg agcggcatag cgcacgtaga acatctcggg gctgttg
//
