LOCUS NZ_BNBM01000014 21041 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence14, whole genome shotgun sequence. ACCESSION NZ_BNBM01000014 VERSION NZ_BNBM01000014.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 281063) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 222413 Orig. end :: 243454 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000014.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..21041 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="2" /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /tool="antismash" cand_cluster 1..21041 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" protocluster 1..21041 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:11041](+)" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..11041 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" gene complement(883..3043) /gene="helR" /locus_tag="IE325_RS31660" /old_locus_tag="GCM10018780_64000" /pseudo="" CDS complement(883..3043) /codon_start=1 /gene="helR" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020121680.1" /locus_tag="IE325_RS31660" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64000" /product="RNA polymerase recycling motor ATPase HelR" /pseudo="" /transl_table=11 /translation="MFDLPERLSPKAEPTLIAGDERHFAAIADCLEKTITELSDRLAAA RRAPGGLGREAMDRDSEIHRLTARLRTLRRFGLDLCLGHGRRRWHRARVRRTARPDRRH GPPTAHRLALPRGRAVLRRHPRQSDGPGQPPQVPLDRRTDQRLLGRGVHPGRLRRACRA RRPVRVHRRPGRQPLTSDAGRARHHPGRPGRRHPRGIPGRTRRRRRTRHGQDSRGPAPL RLSAPLRPPRRPPPGRRAVRRPAPAVSGVRLRCPAQPRRGGRADLRARGPGSGGCHGEG RGRSGGGPSEVVRGPGRGDREGRPVLRGAAREGYDGHDSLVRRPVERRRLGRGVRGGRT RYAAQRGPRPGLGGAAHDPGRQARGGRLGRRRRGPGRAGPQVAHPEQGTADGLQPCVAA PRCHGPGLGPVVGARVSADVRALARPRGGPAVAAGGRAGLDGVRPAAPGRGPAPARGPG RGPAQTPAGGDPRRAARADDAGRRQPDRGHRRLRRRHRRGRRAGDHAAGPGRPGQPGRR VRTADRRPRPARRPVRAHRGGRGAGTDRRRVADAAAALPVPELHHRGRPRPGPARLHRV LARTPRTGRPRPDRPGLPEHQLPHTGRDHGGGRAGDPRRAAGRQCADVHPQRRGAGRAR FRFGPCLDPGHLARRACGGSRLRHRRPHVPPDGPGAVTDAGAVEGPGVRPGRPGEPGGV RPGHRGSGGPLCGDDQGDPATGHPCV" misc_feature complement(929..931) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" misc_feature 3260..3273 /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.49" /tool="antismash" misc_feature complement(3261..3274) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: medium, score: 20.87" /tool="antismash" misc_feature 3461..3475 /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: weak, score: 16.54" /tool="antismash" gene 3546..5138 /locus_tag="IE325_RS31665" /old_locus_tag="GCM10018780_64020" CDS 3546..5138 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007447816.1" /locus_tag="IE325_RS31665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64020" /product="sensor histidine kinase KdpD" /protein_id="WP_190073547.1" /transl_table=11 /translation="MVSVQSPPSRRELPYARVLLLPAIVMAAATGAAVAVVAEPARTAV GVCGAVAVLLVMASAAEAVRRGRLLRDLRADHARHTAYMERRIAAHDEEMSRLATEITP AAIHRLQCGSSAYEVMRDLADIDPSYAHLSRAQLALVESMLAIVDHEEALRDSSQRSFV NIARRVQSIVHQQAVELREMEEDHGRNPEVFDDLLRIDHGTMLIGRLADSISVLGGGRP GRQWPEPVPLYSVLRGAMSRILEYRRISLDSIVHVNIAGISVEPIIHAAAELLDNATRY SPPQTKVHVTATEVQTGIAIEIEDSGVSLSEEARARVEGMLERAKQGTDLQDLGEAPRL GLAVVGRLCTAFNMQVALRTSAYGGVRAVLVVPREMMTTDPAPGLAHGVGAAAAPKADA DALEGPKRAPKKRRPTSPKIPTTVSMEDDVPVVTEWTAGGLPQRRSRVKTPLSKRIAEQ AAIEQAEREGRPTVWSTRRPEPEPEPEKDDEPAPGAWVEAFWNGLKDKPDPYTLQPRTQ PARPEADDEGDIK" gene 5135..5542 /locus_tag="IE325_RS31670" /old_locus_tag="GCM10018780_64030" CDS 5135..5542 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018549147.1" /locus_tag="IE325_RS31670" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64030" /product="roadblock/LC7 domain-containing protein" /protein_id="WP_062722698.1" /transl_table=11 /translation="MIQQRANFDWMLKELHDGVPGIEMIVVLSADGLRIARYGGDPDTA DRVAAACAGLQSLASAVATEIPNSDGKMKMVLIEINGGYFYLMAAGANAYLAVLSDTFA EPGRMSNRMSDLVARIGAHLTSPPRRNGQTV" gene 5539..5940 /locus_tag="IE325_RS31675" /old_locus_tag="GCM10018780_64040" CDS 5539..5940 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003977198.1" /locus_tag="IE325_RS31675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64040" /product="DUF742 domain-containing protein" /protein_id="WP_190073548.1" /transl_table=11 /translation="MTPPKRQRRRPKEKPAPPPPQTGKQKNPERLFVVAGPDGGERDGD LDLVTLIVARADPPPSPTPEQSALLRLCTAPLSVAELSAYLNLPFSMMTVLLTDMLTAG LVTARNPIVRQTVADRSILEAVMHGLQRL" misc_feature 5689..5691 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 5921..6541 /locus_tag="IE325_RS31680" /old_locus_tag="GCM10018780_64050" CDS 5921..6541 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016434372.1" /locus_tag="IE325_RS31680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64050" /product="ATP/GTP-binding protein" /protein_id="WP_190073549.1" /transl_table=11 /translation="MDFKGSDTVPGPRTEDQLPHTAEAAVKIVIVGGFGVGKTTMVGSV SEIRPLTTEETMTQAGIGVDDNFGSDTKTATTVAMDFGRISITEQLVLYLFGTPGQERF WFLWNGLFDGALGAVVLIDTRRLEVSFDVMGRLEERGVPFVVAVNTFPDAPRYPVDELR TALDLPEEIPIIECDVRRRASSRDVLMTLLQFLHALAMAKAPA" gene 6707..8176 /locus_tag="IE325_RS31685" /old_locus_tag="GCM10018780_64060" CDS 6707..8176 /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /GO_function="GO:0005506 - iron ion binding [Evidence IEA]" /GO_function="GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1007: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006380986.1" /locus_tag="IE325_RS31685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64060" /product="cytochrome P450" /protein_id="WP_190073550.1" /transl_table=11 /translation="MTPEPLSPIGTDEPTATPPPGCPAHGIGPDGLRRLHGKEAEDLGA VYEELRAEHGPVAPALLHDDVPVWVVLGHTENMQMLRTPSQFCRDSRLWTAVQDGTLKP DNPLMPHIAWQPICCHAEGDEHVRLRGAVTDAMEAIDHRGVRRYINRATQHLVNKFCET GRADLVSQFAEHLPMVVMCEILGMPDEYNDRLVQAARDLPKGTETAIASNAYVMDVLMR LTAARRAESKDDFASRLVDHPAGLTDDEVGQHLRVVLMAAYEATANLLANVLRVVLTDP RFRAQLSGGQMTVPQAVEQSLWDEPPLSSVLCYYAKQDTELGAQRIRKGDGLILGIAPG NVDPRVRPDLKANMKGNRSHLAFSGGPHECPGQDIGRAIADVGVDALLSRLPDLQLACE EDELRWQASIFNRHLVELPVKFAPKPQQDAMAGPAHPRPPQRPSNGQVGSPQPQTATPE PATPAAAPTRTPEPASRPGLFRRLLRWWRGD" gene complement(8195..9136) /locus_tag="IE325_RS31690" /old_locus_tag="GCM10018780_64070" CDS complement(8195..9136) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1279: pseudouridine synthase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007447831.1" /locus_tag="IE325_RS31690" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64070" /product="RluA family pseudouridine synthase" /protein_id="WP_190073551.1" /transl_table=11 /translation="MRRRSPPPPSPLPQREGVDPVRVRLPAGEAWATVRDHLVARLAAG AEVIDAMLDAGEIVDVAGRPVPRDMAYTPGMYLWFQRKLPDEERVPFTVDVVYQDEHVV VADKPHFLATTPRGSHVAETALARLRRQLDVPTLGAAHRLDRLTAGLVLFTVRPEERGA YQSLFRDKRVTKEYEAVALYDPALDLPRTMRSRIVKERGVMAAREVEGEPNAVSRVELL EHLEGRARYRLVPHTGQTHQLRVHMSALGMPILGDPLYPVVTDPVASGDFRHPLQLLAR VLEFTDPITGCEHRFVSRRVLGAWASYDEWAG" gene 10001..11041 /locus_tag="IE325_RS46715" /old_locus_tag="GCM10018780_64080" CDS 10001..11041 /GO_function="GO:0010333 - terpene synthase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0046246 - terpene biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene: T1TS" /gene_functions="biosynthetic-additional (smcogs) SMCOG1052: Terpene synthase/cyclase metal-binding domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: protein motif:HMM:NF040195.4" /locus_tag="IE325_RS46715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64080" /product="terpene synthase family protein" /protein_id="WP_190073552.1" /sec_met_domain="T1TS (E-value: 2.3e-54, bitscore: 179.4, seeds: 237, tool: rule-based-clusters)" /transl_table=11 /translation="MSPFRIPEFDMPIASSGLSPAMDAVEPDMWAWAAAHQLVRGEAMR RHLARTRPQWATAIYLPGADEAHLRVPNRFMIWAFILDDNLDDSISEGHIESVTYLLDE LVAVCRNLNTPVTNEGRALKEILDDLSQGRTRAWRNVLGESVVRWLNTFLPEARASRAG RVMTIDEYLPHRRNGVCEFIFAHLQEYVRDVELPKGVRDLPAMEQARNLACEWTGLYND IYSVEKEESVGYLHNAVLVARTHRGCSTQEAVDIVAAITNSLLRQFLAACDAAPAQIRA AADYTPTVLAHASDVIDGYRDLVRANYDYHRGAARYSDVAKYMPEAITTSGLRPDWSFT PTITHS" gene complement(11326..12171) /locus_tag="IE325_RS31700" /old_locus_tag="GCM10018780_64090" CDS complement(11326..12171) /codon_start=1 /gene_functions="other (smcogs) SMCOG1200: vibriobactin utilization protein ViuB" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007501125.1" /locus_tag="IE325_RS31700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64090" /product="siderophore-interacting protein" /protein_id="WP_190073553.1" /transl_table=11 /translation="MALRPARKPRKPHSAQVVRTERLTPHMQRVVLGGDGLAEFAADTC TDHYVKMLFSPAGVSYPEPFDLERIREELPREQWPVTRTYTVRAWDPEHRELTLDFVLH GDEGLAGPWAMRAQPGETVRFMGPGGAYAPDPDADWHLLVGDESALPAIARSLESLPDG ATAYAFVEIAGPEEEQKIDSDVEVIWLHRGSRRVGEALLEAVQTLEFPEGRVHAFVHGE AHFVKELRHLLRVERGVAREDLSISGYWRLGHDEDGWQASKRDWNARIEAEQEGAAPAA " misc_feature 12190..12208 /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: weak, score: 23.56" /tool="antismash" misc_feature 12191..12211 /note="TFBS match to MntR, Manganese transport regulator, confidence: weak, score: 20.42" /tool="antismash" misc_feature complement(12315..12330) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: medium, score: 16.38" /tool="antismash" gene complement(12343..13275) /locus_tag="IE325_RS31705" /old_locus_tag="GCM10018780_64100" CDS complement(12343..13275) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003824 - catalytic activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010045305.1" /locus_tag="IE325_RS31705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64100" /product="5'-3' exonuclease" /protein_id="WP_190073600.1" /transl_table=11 /translation="MMRGVTGRLMLLDTASLYFRAYFGVPDSVKAPDGTPVNAVRGLLD FIDRLVKDHRPDALVACMDADWRPEWRVELIPSYKAHRVAEEHEVGPDEEEVPDTLSPQ VPVIEAVLDALGIARVGVAGYEADDVIGTFTARAKGPVDIVTGDRDLYQLVDDERGVRV LYPLKGVGTLQLTDEAWLREKYGVDGGGYADLALLRGDPSDGLPGVPGIGEKTAAKLLA EFGDLAGIMAAVDDPKAKLTPSQRKRLDESRPYVAVAPKVVRVALDVPLSDVDTTLPRA PRDAAGLDELAARWGLGGSLQRLLVTLGA" misc_feature complement(13336..13351) /note="TFBS match to DasR, N-acetylglucosamine dependent repressor, confidence: weak, score: 20.11" /tool="antismash" gene 13462..14538 /locus_tag="IE325_RS31710" /old_locus_tag="GCM10018780_64110" CDS 13462..14538 /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007501129.1" /locus_tag="IE325_RS31710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64110" /product="glycine betaine/L-proline ABC transporter ATP-binding protein" /protein_id="WP_190073554.1" /transl_table=11 /translation="MSSRLEADHLYKVFGRRPNDAVERLRKGADREELRADGTTAAVID ASFTVEPGQIFVVMGLSGSGKSTLLRMLNGLLEPTAGHVRFDGQDLTAIGDRELREVRA KKISMVFQHFALFPHRSVLENAAYGLAVQGVPRAEREKRAAEALELCGLGGWEKSWPDE LSGGMQQRVGLARALATDADLLLMDESFSALDPLIRRDMQDQLLQLQKTLKKTIVFITH DLNEAMRLGDRIAVMRDGRIVQTGTAEDILLRPADDYVASFIQDVDRSRVLTAGSLMDT SVTADAPLCTCETATTETTFVELCAISARLSHRVTVVDDDNKVIGVVPRQRLVGFLGDE SADPSPCDNPEGKVTARA" gene 14531..16357 /locus_tag="IE325_RS31715" /old_locus_tag="GCM10018780_64120" CDS 14531..16357 /GO_component="GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing [Evidence IEA]" /GO_function="GO:0042626 - ATPase-coupled transmembrane transporter activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1044: ABC transporter, permease protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014671663.1" /locus_tag="IE325_RS31715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64120" /product="ABC transporter permease/substrate binding protein" /protein_id="WP_190073555.1" /transl_table=11 /translation="MPRLRLGDWVDSGVDWLVAHMGWLFDAIKAVVEGMYDGVNAVLTA PEPLLLGGILAVLAWWLRGLVPGVLAFGGFALIDSLDLWDRAMSTLALVLVATVIALVI SVPLGIWAARSKTVSAAVRPVLDLLQTMPSMVLLIPAILFFGLGTAAGVIATLIFALAP GVRMTELGIRQVDAELVEAAEAFGTTPRDTLLRVQLPLALPTIMAGINQVIMLSLSMVV IAGMVGTGGLGGAVNEAIGQLDIGFGFEAGVGIVVLAIYLDRITGALGAQISPLGRRAA AKARAAGGVKVWSHRPRPVVAVAGVAALALVAGGMGVFGPTSGTAAASATDVGKGKEIK LGYIPWDEGIASTFLWKELLEQRGFKVTTSQYAAGPLYTGLATGQIDFETDSWLPTTHA EYWEKYGKQLEDLGSWYGPTSLELSVPSYVKGVDSLEDLKSNASKFKGKIVGIEPSAGM MGMLKDKVLKEYGLEGSYDVVDGSTPAMLAELKRAYAKKEPIVVTLWSPHWAYSDYDLK KLKDPKGAWGKGDGVHTLARKGFAGDNPEVGQWLKNFSMTEKQLTGLESQITKAGKGKE QDAVRTWLKQNPGLLDKWAPIDASDLKNQAAG" gene 16875..17444 /locus_tag="IE325_RS31720" /old_locus_tag="GCM10018780_64130" CDS 16875..17444 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /codon_start=1 /gene_functions="other (smcogs) SMCOG1148: hypothetical protein" /gene_kind="other" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007501133.1" /locus_tag="IE325_RS31720" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64130" /product="helix-turn-helix domain-containing protein" /protein_id="WP_190073556.1" /transl_table=11 /translation="MGDHKEQPLRVGAAVRRRRRALDLTLAVVAERSGLSVPFLSQVEN DRARPSRSSLEKVADALRTTAVELLAAADPACSVDVVRAEGNELGPEPRVRSLVRGHHQ MHASEFTGDHDAGREFQYRNDQLMYVADGAVEIEAEGRAYRLGRGDSLYLTGGVRHRWR ATVPDTRVVVVAVAEHIEAVRNRPGR" gene 17444..18154 /locus_tag="IE325_RS31725" /old_locus_tag="GCM10018780_64140" CDS 17444..18154 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020117683.1" /locus_tag="IE325_RS31725" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64140" /product="helical backbone metal receptor" /protein_id="WP_190073557.1" /transl_table=11 /translation="MRVVSLVPSLTEAVADLGVLVGATDWCSHPADLDVTRVGGTKNPK VDRVLALAPDLVIANEEENREPDLAALRAAGVDVLVTEVRDVPQAFGELARVLEACGVT ARPRWLDEAEDAWSSPAPDRRTTAVVPIWRRPWMVLGRDTFAGDVLARLGVDHVYTTHE DRYPRIPLDDLREAAPDLVVLPDEPYRFTADDGPEAFPGLPCALVSGRHLTWYGPSLAE APRVLTAALRAAHR" gene complement(18066..19223) /locus_tag="IE325_RS31730" /old_locus_tag="GCM10018780_64150" CDS complement(18066..19223) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015661678.1" /locus_tag="IE325_RS31730" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64150" /product="TDT family transporter" /protein_id="WP_190073558.1" /transl_table=11 /translation="MVTAARHLGPTRRLGVRHLGPNWYAAVMGTAAVATAGAGLPLHLP GLRTVCAAVWALSLALLVTLLGARAAHWSHHRDQARAHLLDPAMAPFYGCLSMALLAVG GGALVVGRDWIGTSAAVALDAVLFAAGTAIGLAAAVAVPYLMAVRHRVEPSEATPVWLL PLVAPMVSAALGPLLVPHLPAGQARETLLLACVAMFGLSLLATLLMLPLVFARLITGGP LPLVLTPSLFLVLGPLGQSTTAVGVFADVAPGVVPAPYSEGFGMLAVLYGVPVMGFALL WFGLATAHVLRARRHGMGFAMTWWAFTFPVGTCVTGATALARHTGLVVYEGLAVGLYVV LVAAWGVAAVHTTRGLFSGALLAGPPSVPVVPRQVTGRTTSGAAR" gene 19294..20217 /locus_tag="IE325_RS31735" /old_locus_tag="GCM10018780_64170" CDS 19294..20217 /GO_function="GO:0001216 - DNA-binding transcription activator activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1014: LysR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004002559.1" /locus_tag="IE325_RS31735" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_64170" /product="LysR family transcriptional regulator" /protein_id="WP_190073559.1" /transl_table=11 /translation="MTEVAEGQFRAGSLSHRVPELGALELLLAVARLGSLGGAARELGI TQPAASSRIRSMERQLGVALVDRSPRGSRLTDAGALVTDWARRIVEAAEAFDAGAQALR DRRDSRLRVAASMTIAEYLLPGWLLALRAQRPDTAVSLLAGNSAAVAERLLADEADLGF VEGVSVPTGLDSVVIAHDNLIVVTAPGHVWARRRRALSGAELAATPLILREEGSGTRQV LDSALGGLARPLIELSSTTAVKAAAVGGAGPAVLSELAVGEELSMRRLVSVPLADVSLA RDLRAVWPTGHRPVGPARDLLALTRG" misc_feature complement(20859..20874) /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 20.67" /tool="antismash" ORIGIN 1 cccgcgctcc ccgcagtccc gtcgggacct ggcgtccgcg ctgcgctcca aggccgggca 61 catcgtgccc gaccggcacc gcaagcgcgg ctcgcaggcg accgacgacc gtgagatcgc 121 ccggttgcgc aaggcgatcc gcgcccaccc ctgccacggc tgcgacgacc gtgaggacca 181 cgcccgttgg gccgagcgct atcaccggct gatgcgtgac acctcgcagc tggagcgccg 241 tatcgaaggc cgcacgaaca cgatcgcgcg caccttcgac cgcatcgtcg cgctgctgac 301 cgagctggac tatctgcgcg gcgacgaggt caccgagcac ggcaagcggc tcgccaggct 361 ctacggcgaa ctggacctgc tggccagtga atgcctgcgc gagcgggtgt gggagggcct 421 cggccccgcc gaactggcgg cctgtgtctc ggcgttggtg tacgaggcac gggtcgggga 481 cgacgccatg gcgccgaagc tgccctcggg caaggccaag gccgcgctcg gggagatggt 541 gcggatctgg ggccggttgg acgcgctgga ggaggacttc cggatcaccc agtccgaggg 601 cgtcgggcag cgcgaacccg atctgggctt cgcctgggcg gcgtacatgt gggccagtgg 661 caaggggctg gacgaggtgc tccgggaggc tgagatgccg gccggggact ttgtgcggtg 721 gtgcaagcag gtgatcgacg tgctcgggca gatcgctgcg gcttctccgg tggagggctc 781 caccgtgacc aagaatgcgc gtaaggctgt ggaagggctg ctgcgggggg ttgtcgccta 841 ctcttcggtg gggtgaggcg ttcggcgacc ggtggaggtc ggtcacgcaa ggatgaccag 901 ttgctgggtc gccctggtca tcgccacata acggtccacc gctccctcga tgccctggcc 961 gaactcctcc gggttcacca ggacgaccag gtcgaactcc aggcccttcg acagctccgg 1021 cgtcagtgac cgcacccggt ccgtcgggcg gaacgtgggg tcgccgatga cgcaggcgac 1081 tccctccgca tgctcggcga gccaggtgtc caggatcgag gcaaggtccg aaacggaacc 1141 gtgcacgacc ggcacccctc cgctgcggat ggacgtcggc acattggcgt ccggcagcgc 1201 ggcgcggatc accggctcgg cctccgccat gatctcttcc ggtgtgcggt agttgatgtt 1261 cagggaggcc aggtcgatcc ggtcgaggcc gacccgttcg aggcgttcgc gccaggactc 1321 ggtgaagccg tgccgggcct gggcgcggtc gcccacgatg gtgaagctcc gggacgggca 1381 gcgcagcagc agcatctgcc actcggcgtc ggtcagttcc tgcgcctcgt ccaccacgat 1441 gtgcgcgaac gggccggcga gccggtcgag gtctccggtc ggcagttcgg actcgtcgac 1501 caggctgacc tgggcgtcct ggccccgcag catgatcacc agcccttcgc cctcgtcggt 1561 gtcggcgccg gagtcggcgg tggcctcgat caggttgtcg acgacctgcg tcatccgctc 1621 gcgctgcgcg gcgaggatcc cctcctgccg gtgtctgcgc cgggccgcgt ccgggtcccc 1681 gagccggtgc cgggccgcgt ccaggagcgg caggtcggac accgtccagg cctgcgcgtc 1741 cgcccgctgc aaccgctgga cctcctcgcg gccgagccag ggcgcgcaca tccgcagata 1801 cgcgggcacc gaccacaggt ccgagaccag gtccgtggca tcgaggagcg gccacgcacg 1861 gttgaaggcc gtcagcagtt ccctgttccg ggtgagcgac ctgcggacca gctcggccgg 1921 gacctcgccg tcgtcgcccg aggcgtcctc ctcgtgcctg tcgaccagga tcgtgagcag 1981 ctcctcccag acctggtcgc gggcctcgtt gtgcggcgta ccgggttcgg ccgcctcgaa 2041 cgccacggcc cagtcgacgc cgctcaaccg gacgtcggac cagggagtcg tgaccgtcat 2101 acccttcgcg ggcggctcct cgtagaaccg gacggccttc tcgatcgccc cgaccaggtc 2161 cgcggacgac ttcagacggg ccacctccgg atcggcctcg gccttcgccg tggcaccctc 2221 cggaaccagg tccgcgagca cgcaggtctg cacgccctcc tcgccgaggc tgggcaggac 2281 atcggagacg tacgccagat acggccggtg cgggccgacg aacagcacgc cgccccggcg 2341 gtggtcgacg cgggggtcgg agtggagcag ataggcggag cggtgcaggg ccacgactgt 2401 cttgcccgtg ccgggtccgc cgtcgacgac gagtgcgccc cgggatcccg cgcggatgac 2461 ggcgtcctgg tcggcctgga tggtggcgag cacgtcccgc atccgaggtg agcggttgcc 2521 gcccaggccg gcgatgaacg cggactggtc gtcgagcgcg gcatgcccgg cgaagccgtc 2581 ctgggtgaac acctcgtccc agtagtcgct gatccgtccg ccggtccagc ggtacctgcg 2641 gcggctggcc aggcccatcg gattggcgtg ggtggcgccg aagaacggct cggccgcggg 2701 ggagcgccag tcgatgagca gtcggcggcc cgtgtcgtcg gtcaggccga gccgtccgac 2761 gtacacgggc tcggtgccat ctgcgccgac catgcccgag gcacaggtcg aggccgaagc 2821 ggcgcagggt gcgcagccgg gcggtgagcc ggtggatctc gctgtcccgg tccatcgcct 2881 cccggcccag gccccccggc gccctgcgcg cggcggcgag acggtcggac agctcggtga 2941 tcgtcttctc caggcagtcg gcgatggccg cgaagtgcct ctcgtcgccg gcgatcagag 3001 tcggttcggc tttgggggag aggcgttcgg gcaggtcgaa cacgctggtt tcggcttggc 3061 tcctactgtc actcaactgc acacgcactt ctacgactcc cgtttccgca ggtcctcggc 3121 ctaggccggt gattgtgcgg tacaacgggg gccttgccgc aagccccccg gtgcgctata 3181 cgttgagagt ggcgaggagc aggtggctcc ttgcccttct tttttgccta ggtccgggct 3241 cggaacccga tcttcacccg tcacggtgag tgactttcgc acgtgcgtgc gccgtgacgc 3301 agtgtattcg aacgtaatct gagcgtataa atggggccga gcgtactcct gtctcgcacc 3361 ccatttcagg tgcttgctga atatgacaca gcgatgatcc ggtcggacta agctcgcccg 3421 cagcgcaccg agttgaggtg tattcgtgcg cttgttccca aacatgcaga agattccgac 3481 atacccatga cgtaccccgc tgcaagctcc ccctacaccc aaccgattcg tttcagaggg 3541 cccacatggt gagcgttcaa tccccgccga gtcgccgtga actcccgtac gcgcgcgtac 3601 tgttgctgcc ggccatagtg atggccgcgg cgaccggagc cgccgtcgcc gtggtggcgg 3661 agccggcccg gacggccgtc ggcgtatgcg gtgccgtggc cgttctgctg gtgatggcct 3721 ccgcggccga agcggtgcgt cgaggccgcc tcctgagaga cctgcgggcc gaccacgccc 3781 gtcacaccgc gtacatggag cgccgtatcg ccgcccatga cgaggagatg tcccggctcg 3841 ccacggagat cacaccggcc gcgatccacc ggctgcaatg cggcagttca gcgtatgagg 3901 tgatgcgaga cctcgccgac atcgatccgt cctacgccca tctctcccgg gcacagctcg 3961 cgttggtgga gtcgatgctc gccatcgtcg accacgagga agccctccgc gactcctccc 4021 agcgctcctt cgtcaacatc gcccgccgtg tccagtcgat cgtccaccaa caggccgtgg 4081 aactgcggga gatggaggag gaccacggcc gcaaccccga ggtcttcgac gacctgctgc 4141 gcatcgacca cggcaccatg ctgatcggcc gcctcgccga ctccatctcc gtgctcggcg 4201 gcggccggcc cggccgccag tggcccgaac ccgtcccgct gtacagcgtg ctgcgcggcg 4261 ccatgtccag gatcctggag taccgccgca tcagcctgga ctccatcgtc cacgtcaaca 4321 tcgccggaat ctccgtcgag ccgatcatcc acgccgcggc cgaactcctc gacaacgcca 4381 cgcgctactc cccgccgcag accaaggtgc acgtcaccgc caccgaggtg cagaccggaa 4441 tcgcgatcga gatcgaggac tccggcgtca gcctcagcga ggaggcccgc gcccgggtcg 4501 agggcatgct ggagcgcgcc aagcagggca ccgacctcca ggacctcgga gaggccccac 4561 gcctgggcct ggccgtcgtg ggccgtctct gcacggcgtt caacatgcag gtcgcgttgc 4621 gaacctcggc gtacggcggc gtccgcgccg ttctcgtggt gccgcgcgag atgatgacca 4681 ccgaccccgc gcccggactc gcccacggcg tcggcgccgc ggcggcgccc aaggccgacg 4741 ccgacgccct cgaaggcccc aagcgtgccc ccaagaagcg tcgccccacc agcccgaaga 4801 tccccaccac ggtctccatg gaggacgacg tccccgtggt caccgagtgg accgcgggcg 4861 ggctgccgca gcgccgcagc cgggtgaaga ccccgctcag caagcgcatc gccgagcagg 4921 cggccatcga gcaggcagag cgggagggca ggcccaccgt ctggtcgacg cgcaggcccg 4981 agccggagcc cgagccggag aaggacgacg agcccgcccc cggagcatgg gtcgaggcgt 5041 tctggaacgg actcaaggac aagcccgacc cctacacact ccagccgcga actcaaccgg 5101 cccgccccga ggccgatgac gagggggaca tcaagtgatc cagcagcgcg ccaacttcga 5161 ctggatgctc aaggagctcc acgacggcgt acccggcatc gagatgatcg tggtgctctc 5221 cgccgacggt ctgcgcatcg cccgctacgg cggtgacccg gacaccgccg accgcgtcgc 5281 tgcggcgtgc gccggtctgc agagcctggc gagcgctgtc gccacggaga tccccaacag 5341 cgacggcaag atgaagatgg tcctcatcga gatcaatggc ggctacttct atctgatggc 5401 cgccggcgcc aacgcctatc tcgccgtgct ctccgacacg ttcgccgagc cgggtcggat 5461 gagcaaccgg atgtccgacc tcgtcgcccg gatcggtgcc catctcacca gtccgccccg 5521 gcgcaatggg cagaccgtat gactcctccg aaacgccagc ggcgacgtcc caaggagaaa 5581 ccggcaccac cgccgcccca gacggggaag cagaagaacc cggagcggct cttcgtggtg 5641 gccggaccgg acggcggcga gcgcgacggc gacctcgacc tcgtgacctt aatcgtggcg 5701 cgcgccgacc ccccgccgtc accgacgccc gagcagtcgg cgctgctccg gctctgtacc 5761 gcccctctgt ccgtggccga gctgtcggcc tacctcaacc tgccgttcag catgatgacg 5821 gtcctgctca ccgacatgct gacggccgga ctggtgacgg cacgcaaccc gatcgtgcgc 5881 cagaccgtcg ccgaccgttc aatcctcgaa gcggtgatgc atggacttca aaggctctga 5941 caccgttccc ggtccgcgga ccgaggacca gctgccgcac acggccgagg ccgccgtgaa 6001 gatcgtgatc gtgggcggct tcggcgtcgg aaagacgacc atggttggct cggtcagcga 6061 gatcaggccg ctgaccaccg aagagaccat gacgcaggcc ggtatcggcg tcgacgacaa 6121 cttcggctcg gacaccaaga cggccaccac cgtcgcgatg gacttcggcc gcatcagcat 6181 caccgagcaa ctggtgctgt atctcttcgg tacgcccgga caggagcgct tctggttcct 6241 gtggaacggc ctgttcgacg gcgcgctcgg cgcggtcgtg ctgatcgaca cgcgccgcct 6301 cgaggtcagc ttcgacgtca tggggcggct ggaggagcgc ggtgtgccgt tcgtggtggc 6361 cgtcaacacc ttcccggacg cgccccgtta ccccgtcgac gaactccgga cggcactcga 6421 tctgcccgag gagatcccca tcatcgagtg cgacgtacgt cgccgggcct ccagccggga 6481 cgtattgatg acgttgctgc agttcctgca cgcgctggcc atggcgaagg cgcccgcatg 6541 atctgcagac cggtcgcacc gcacgtgtcc tgaacatgtg cgcagacggc gcccgccccg 6601 tctgcacgac ctctgcccgg ttctcggctt cgatcgaatc gcctgaaccg gggcatcccg 6661 ttacctcttg tacagccgga atcacttcag cttcggagcg accaccgtga cgcctgaacc 6721 tctctccccg atcggtacgg acgagcccac ggccacccca ccgcctggct gccccgcaca 6781 cggcattggc cccgacgggc tgcgccgact gcacggcaag gaggcagagg acctgggagc 6841 cgtgtacgag gaactccgtg ccgagcacgg ccccgtggct cccgccctgt tgcacgatga 6901 cgtgccggtc tgggtggtgc tcggccacac cgagaacatg cagatgttgc gcacgccctc 6961 gcagttctgc cgtgacagtc ggttgtggac cgcggtgcag gacggcaccc tgaagcccga 7021 caacccgctc atgccgcaca tcgcatggca acccatttgc tgccatgccg agggcgacga 7081 gcatgtgcgg ttgcgtgggg cggtcaccga tgccatggaa gccatcgacc accggggcgt 7141 ccgccgctac atcaaccgcg cgacccagca cctcgtcaac aagttctgcg agacaggcag 7201 agccgatctg gtcagccagt tcgccgagca cctgccgatg gtggtcatgt gcgagatcct 7261 cggtatgccc gacgagtaca acgaccgact cgtgcaggcc gcccgcgact tgcccaaggg 7321 caccgagacc gcaatcgcca gcaacgcgta cgtcatggac gtcctgatgc ggctcaccgc 7381 ggcccgccgg gccgaatcca aggacgactt cgccagtcgc ctcgtcgacc acccggccgg 7441 gctcactgac gacgaggtcg gccagcacct gcgcgtcgtc ctgatggccg catacgaggc 7501 caccgccaac ctcctcgcca acgttctgcg tgtggtgctc accgacccgc ggttccgagc 7561 ccagctcagc ggcggtcaga tgacggtgcc ccaggcggtc gagcagtccc tgtgggacga 7621 gccgccgctc agcagcgtcc tgtgctacta cgccaagcag gacaccgagc tgggtgccca 7681 gcgcatccgt aagggtgacg gcctcatcct gggcatcgcg ccgggcaacg tcgacccgcg 7741 ggtccgtccc gacctcaagg ccaacatgaa gggcaaccgt tcccacctgg ccttcagtgg 7801 cggtccccac gagtgtccgg gccaggacat cggccgcgcc atcgccgatg tgggcgtcga 7861 cgccttgctg agccgcctcc cggatctcca actcgcctgc gaggaggacg aactgcgctg 7921 gcaggcgtcc atcttcaacc ggcacctggt ggagctgccg gtgaagtttg cgcccaagcc 7981 tcagcaggac gccatggcgg gacccgcgca cccacggccg ccgcagcgtc ccagcaacgg 8041 ccaggtcggt tcgccgcaac cgcagacagc gactccggag ccggccactc cggccgcggc 8101 cccgacccgg acgccggaac cggcttcccg accgggcctg ttccggcgcc tgctgcgctg 8161 gtggcgcggc gactgatccg cgccggcacg ggtgctaccc ggcccactcg tcgtacgacg 8221 cccaggcccc cagcacacgc cgactgacga agcggtgctc gcaccccgtg atgggatcgg 8281 tgaactccag cacccgcgcc agcagttgga gcggatgtcg gaagtcgccg gaggccacgg 8341 ggtcggtcac caccggatag aggggatcgc cgaggatcgg catccccaac gcgctcatat 8401 ggacgcgaag ctggtgcgtc tgcccggtat gcggtacgag ccggtaccgg gcacgcccct 8461 ctaggtgctc cagcaactcg acccggctga cggcgttggg ctcgccctcg acctcgcggg 8521 ctgccatcac cccacgctcc ttgacgatcc ggctgcgcat ggtgcgcggc aggtccagtg 8581 cggggtcgta cagggcgacg gcctcgtatt ccttcgtcac ccgcttgtcg cggaagagtg 8641 actggtaggc gccgcgttcc tccggccgca cggtgaacag caccaggccc gccgtcagcc 8701 ggtccagacg gtgggcggcg cccagggtcg ggacgtcgag ctgcctccgc agccgtgcca 8761 gggccgtctc ggctacatga ctaccgcgcg gggtggtggc cagaaagtgc ggcttgtcgg 8821 ccaccaccac gtgttcgtcc tggtagacga cgtcgaccgt gaacggtacc cgctcttcat 8881 caggcaactt ccgctggaac cacaggtaca tcccgggggt gtacgccatg tcccgcggca 8941 ccggacgtcc ggccacgtcc acgatctccc ccgcgtcgag cattgcgtcg atcacctcgg 9001 ccccggcagc gagccgcgcc acgagatgat cccgcacggt cgcccatgct tccccggccg 9061 gcaaccgcac tcgtaccgga tccacccctt cgcgctgcgg caggggagag ggcgggggcg 9121 gactacggcg tctcatcacg atcaagccta cgccggggcg ctgacagcga aagggcgagg 9181 cggcgctccg gaagggactt gcgcgctcct tgtacaccca gcgtcgggat tccgcggatg 9241 tccccggttg tacgtgaggt gatccaggag ccagcccccg catcagccgc cgcaggagtg 9301 ctgcgatctc cttcaggggc gcacgtcctg gtcgtgtacg catcagtgtg cggaaggggg 9361 cgccttcccc cgtgggctta tggctggcac agttatagaa ctcgtccgga tcgtacaagc 9421 ggtctaggag cggtatgagc ctcctgtagg ccgggtgcgt ggggtgatac ctgtgggcga 9481 gtacaactgc gggacagtcg ttgtcggcgt tgcgcgttcc agcgacgttg caggcacttc 9541 ccgccgacag gcatggccaa ctggcggccg aattcagcga gtttcctggc gaaggtccga 9601 gccgtgtggg ccggtttcga cggttcacct tgctgcggca tgtctacggc ccgtccgtgc 9661 gctccccctc gcaggcggaa ccgagcaagc tgctcggtcc tgtcgcggtg cgcagaccgt 9721 gtccggccca tgccgactgg cgaacgcgaa caccactacc cggaggacgt catgagcgca 9781 cccggcaagt gtgtccagct cgcagcacca acgggcccga ggcttctgcg agtaggcgct 9841 tgaccgtgcg ggtcccctga ccaccaacgc cgcgagatcg tgcacaacac gtaggtcgtg 9901 cggggggtca agaaggaggg tgcgatgttc cgccatgtac caggccgctc atgcaccgac 9961 gctcccgcat ccgagcatcc ccgtgcctca ggaggaagtc atgtccccat tccgcatacc 10021 cgaattcgac atgcccatcg cgtccagtgg tctctcaccc gcgatggacg cggtcgagcc 10081 cgacatgtgg gcatgggccg ccgcccatca gcttgtgcgc ggtgaagcaa tgcgtcggca 10141 tctggcccgt actcgaccgc agtgggccac cgcgatctac ttgcccggcg cggacgaagc 10201 ccatctgcgg gtaccgaacc ggttcatgat ctgggccttc atcctcgacg acaacctcga 10261 cgacagcatc agtgagggac acatcgagtc cgtcacgtac ttgctggacg aactcgtcgc 10321 cgtctgccgc aacctgaaca cccccgtcac caacgaagga cgggctctca aagagatcct 10381 cgacgacctc tcccaaggtc gcacaagggc ctggcgcaac gttctggggg aatccgtggt 10441 gcgctggctg aacaccttcc tgccagaagc ccgcgcgagc cgggcgggcc gcgtcatgac 10501 catcgacgaa tacctgcccc accgccgcaa cggagtctgc gagttcattt tcgcccacct 10561 gcaggagtac gtcagggacg tcgaactgcc caagggggtg cgcgacctgc ccgcgatgga 10621 acaggcccgc aaccttgcat gtgaatggac cggtctctac aacgacatct actccgtgga 10681 gaaggaggag tcggtcggct atctccacaa cgccgttctt gtcgcgcgca ctcaccgcgg 10741 ctgttccacc caggaggccg tggacatcgt cgctgccatt accaatagcc tcctccgcca 10801 attcctcgcc gcctgcgatg cggcccccgc ccagatccgc gccgccgccg actacacccc 10861 caccgtgctc gcccacgcca gcgatgtgat cgacggttac cgggaccttg tccgcgcgaa 10921 ctacgactac caccgaggcg ccgcccgcta cagcgacgtc gccaagtaca tgccggaagc 10981 catcaccacc agcggactgc ggcctgactg gagcttcacg ccgaccatca cccattcctg 11041 agtcggcccc tgcaccggtg tgtgtcaact tagcggctga tcttggtgag tgtggtccga 11101 ataggttgtc tcgtcccgct gatgtcatgt gatgtcgacg ggccttgagc gcgcccggtg 11161 atccgaggcc gggccggcgg tcccactgac agaggggagc gtcggtccgg ttcctccgac 11221 catggtccat cgcggatgca tgactggagt tacgccctca cccggggcga ggcatgagaa 11281 agaggcggca cccatgaggt gccgcccctt cccgagccac agggactacg ccgccggcgc 11341 cgccccctcc tgctccgcct cgatccgtgc gttccagtcc cgcttggagg cctgccagcc 11401 gtcctcgtcg tggccgaggc gccagtagcc ggagatggac aggtcctctc gagccacgcc 11461 gcgctcgacg cgcagcagat gacgtagttc cttcacgaag tgcgcctcgc cgtgcacgaa 11521 ggcgtgcacc cggccctcgg ggaactccag agtctgaacc gcctcgagca gtgcctcgcc 11581 gacccggcgg gaaccgcggt gcagccagat cacctccaca tcggagtcga tcttctgctc 11641 ttcctcgggg cccgcgatct ccacgaaggc gtaggccgtg gcgccgtcgg gcagtgactc 11701 cagggagcgg gcgatggcgg gcagggcgct ctcgtcgccg accagcagat gccagtcggc 11761 gtccgggtcg ggggcgtagg cgccgccggg gcccatgaag cgcacggtct cgccgggctg 11821 ggcgcgcatc gcccacggtc cggccaggcc ctcgtcgccg tgcagcacga agtccagtgt 11881 cagctcacgg tgttcgggat cccaggcccg cacggtgtaa gtccgcgtca ccggccactg 11941 ctcacgcggc agttcctcgc ggatgcgctc caggtcgaac ggctcggggt agctcacccc 12001 ggcgggcgag aacagcatct tcacgtaatg gtccgtgcag gtgtccgccg cgaactcggc 12061 gagcccgtca ccgcccagca ccacacgctg catgtgcggg gtcagccgtt cggtacggac 12121 gacctgcgcg gagtggggct tccgcggctt gcgggcaggg cgtagcgcca tcactggcct 12181 ccctcgttcc aagcttaggt ttacctaagt tagcacctcc gtccggcgaa tgccgctatg 12241 aacgttcatg agaaaggggc atgtcgtgcg tacacggaac gaattccccg cgtcacaagc 12301 cccatgcgcg cgatcgtgac gcccctcacg cccccggcga tctcacgccc ccagcgtcac 12361 cagcagccgc tgaagcgacc cgcccaaccc ccagcgcgcc gccagctcgt ccagccccgc 12421 cgcgtcccgg ggagcgcgcg gcagtgtggt gtcgacgtcg gacagcggga cgtccagcgc 12481 gacccggacg accttcggcg cgacggcgac atacgggcgg gactcgtcca gccgcttgcg 12541 ctgcgagggc gtcagcttcg ccttcgggtc gtcgaccgcc gccatgatcc cggccaggtc 12601 gccgaactcc gccagcagct tcgccgccgt cttctccccg atccccggca cgcccggcag 12661 gccgtcgctc gggtcgccgc gcagcagcgc cagatccgcg tacccgccgc cgtcgacgcc 12721 gtacttctca cgcagccacg cctcgtcggt gagctggagg gtgccgacgc ccttgagggg 12781 gtacagcacc cgcaccccgc gctcgtcgtc caccagctgg tacaggtcgc ggtcgccggt 12841 gacgatgtcg accgggccct tcgcgcgcgc cgtgaacgtg ccgatcacgt cgtccgcctc 12901 gtaccccgcg acgcccacgc gcgcgatgcc gagcgcgtcc aggacggcct cgatgaccgg 12961 tacctgcggc gacagcgtgt ccggcacctc ctcctcgtcc ggtcccacct cgtgctcctc 13021 ggcgacccgg tgcgccttgt aggaggggat cagctcgacc cgccactcgg gccgccagtc 13081 ggcgtccatg caggccacca gcgcgtccgg gcggtggtcc ttgaccaggc ggtcgatgaa 13141 gtcgaggagc ccgcgcacgg cgttcaccgg ggtgccgtcc ggggccttca cggagtccgg 13201 gacgccgaaa taggcgcgga aatagagcga ggcggtgtcg aggagcatca gtcgtccggt 13261 cacgccacgc atcatgccgt acggcactga cagtggcccc tcggtcagcg gcgcgttgcc 13321 gtccacgacc accgctgtgg cctggaccac ttgtgcgttt gtgtgcgggg aaccagggca 13381 ggcgcgcacc cggagcgacg ccccctgcgc aactgttgcg ccagtcgctc ccttcgtttg 13441 ccgtcgagac aagaggtacc cgtgtcatcc aggcttgagg ccgaccatct gtacaaggtg 13501 ttcggcagac gaccgaacga cgccgtcgag cggctccgca agggagccga ccgggaggag 13561 ctgcgcgccg acggcaccac cgccgccgtg atcgacgcct ccttcaccgt ggaacccggc 13621 cagatcttcg tcgtcatggg cctgtccgga tcgggcaagt ccaccctgct gcgcatgctc 13681 aacgggctcc tggagccgac cgccggtcac gtccgcttcg acggccagga cctgaccgcg 13741 atcggcgacc gcgagctgcg cgaggtccgc gcgaagaaga tcagcatggt cttccagcac 13801 ttcgcgctct tcccgcaccg cagcgtcctg gagaacgccg cctacggtct cgccgtccag 13861 ggagtgcccc gcgccgagcg cgagaagcgc gccgccgagg cactcgagct gtgcggtctg 13921 ggcggctggg agaagtcctg gcccgacgag ctgtccggtg gcatgcagca gcgcgtgggc 13981 ctcgcccgcg ccctcgccac cgacgccgac ctgctcctga tggacgagtc cttcagcgcg 14041 ctcgacccgc tgatccgccg tgacatgcag gaccagctgc tccagctcca gaagaccctg 14101 aagaagacca tcgtcttcat cacccatgac ctcaacgagg ccatgcggct cggcgaccgc 14161 atcgccgtca tgcgcgacgg ccgtatcgtc cagaccggca ccgccgagga catcctcctg 14221 cgccccgccg acgactacgt cgcctccttc atccaggacg tcgaccgctc ccgcgtactg 14281 accgcgggct ccctcatgga cacctcggtc accgccgacg cccccctgtg cacctgcgag 14341 accgcgacca ccgagacgac cttcgtggaa ctgtgcgcga tcagcgcccg actgtcgcac 14401 cgcgtcaccg tcgtggacga cgacaacaag gtcatcggag tcgtgccgag gcagcggctc 14461 gtcggtttcc tcggcgacga gagcgccgat ccctcgccct gcgacaaccc cgaggggaag 14521 gtgaccgccc gtgcctaggc tgcgtctcgg tgactgggtc gactccggtg tggactggct 14581 cgtcgcccac atgggctggc tcttcgacgc gatcaaggcg gtcgtcgagg gcatgtacga 14641 cggcgtcaac gccgtcctga cggcacccga gcccctgctc ctcggcggca tcctcgccgt 14701 gctcgcctgg tggctgcgcg gcctggtccc gggcgttctc gccttcggcg gcttcgcgct 14761 gatcgactcc ctcgacctgt gggaccgcgc catgtcgacg ctggccctcg tcctggtcgc 14821 cacggtcatc gccctggtga tctcggtccc gctgggcatc tgggcggccc gctccaagac 14881 ggtcagcgcg gccgtacggc ccgtcctgga cctgcttcag acgatgccgt cgatggtgct 14941 gctcatcccg gccatcctct tcttcggcct gggcaccgcc gccggcgtca tcgccaccct 15001 gatcttcgcg ctcgccccgg gtgtccgtat gaccgagctg ggcatccgcc aggtcgacgc 15061 ggagctggtc gaggccgccg aggcgttcgg caccacacca cgcgacaccc tgctgcgcgt 15121 ccagctgccg ctcgcgctgc ccacgatcat ggccggcatc aaccaggtga tcatgctgag 15181 cctgtccatg gtcgtcatcg ctggcatggt cggcaccggc ggcctcggcg gcgcggtcaa 15241 cgaggccatc ggccagctcg acatcggctt cggcttcgag gcgggcgtcg gcatcgtcgt 15301 cctcgccatc tacctggacc gcatcaccgg cgcgctcggc gcgcagatct ccccgctcgg 15361 ccgccgtgcc gccgccaagg cccgtgccgc cggcggcgtc aaggtctgga gccaccggcc 15421 ccgcccggtc gtcgccgtcg ccggcgtggc cgccctggcc ctcgtggcgg gcggcatggg 15481 cgtcttcggc cccacctccg gtaccgccgc ggcctccgcc acggacgtcg gcaagggcaa 15541 ggagatcaag ctcggctaca tcccgtggga cgagggcatc gcctccacct tcctctggaa 15601 ggaactgctg gagcagcgcg gcttcaaggt caccaccagc cagtacgccg cgggccccct 15661 ctatacgggc ctcgccaccg gccagatcga cttcgagacg gactcctggc tgcccaccac 15721 acacgccgag tactgggaga agtacggcaa gcagctggag gacctcggct cctggtacgg 15781 cccgacctcc ctggagctct ccgtcccctc gtacgtcaag ggcgtggact ccctggagga 15841 cctcaagagc aacgcctcca agttcaaggg caagatcgtc ggcatcgagc cgagcgccgg 15901 gatgatgggc atgctcaagg acaaggtcct caaggagtac ggcctggagg gctcctacga 15961 cgtcgtcgac ggctcgacgc ccgcgatgct cgccgagctc aagcgcgcgt acgccaagaa 16021 ggagcccatc gtcgtcacgc tctggtcgcc gcactgggcg tacagcgact acgacctgaa 16081 gaagctcaag gaccccaagg gcgcctgggg caagggcgac ggcgtgcaca ccctcgcccg 16141 caagggcttc gccggcgaca accccgaggt cggccagtgg ctgaagaact tctccatgac 16201 cgagaagcag ctcaccggcc tggagtcgca gatcaccaag gccggcaagg gcaaggagca 16261 ggacgccgtc cgcacctggc tgaagcagaa ccccggtctg ctggacaagt gggccccgat 16321 cgacgcgtcg gacctcaaga accaggcggc cgggtgacct gacggacccg gaccgccgcc 16381 cgaggggcgg gtcacgccgt acgtttttcc cctccgtacg gcatggcccg cccctcgcgg 16441 catgtccgca tagtcacccg gcatgcctac gaaaaggatc cggccaacca cgcagcgcta 16501 tcccaccgcc cgagccgcct catgcgaact ccccccgacc ggcaccgact tcccgctccc 16561 gccaccactc tgaccaggcc cgcccgcagg agcgaagccg ggaacaccgg ggagcgcccg 16621 agcattgaac agaacagcgg ctctcgcgta ctgagcggca gtcaggggcg ccatgggggc 16681 gccctgcggg tgcggggtgc cgatccgctg gcgcgaaccc gtgggtcgca cttcccccaa 16741 ggtgtcgtcg atgtgacggg cgcatgaaac ggtttgccga acatgcgtag ggtgcagaga 16801 actcaacaga aggtgtgcgc cggacgacgg gcgcgaggac agtggaccga cgagcgaagg 16861 agggagccgg agcgatgggc gaccacaaag aacagcccct tcgggtgggt gcggccgtgc 16921 ggcggcgacg ccgtgcgctg gacctcaccc tcgccgtcgt ggccgagcgc agcggcctgt 16981 cggtgccctt cctgagccag gtcgagaacg accgggcgcg ccccagccga agctccctgg 17041 agaaggtcgc cgacgccttg cgcacgaccg ccgtggagct tctcgccgcc gccgacccgg 17101 catgcagcgt cgacgtggtg cgcgccgaag ggaacgagtt gggacccgaa ccgcgggtgc 17161 gttcgctggt gcgcggtcat caccagatgc acgcctcgga gttcaccggc gaccatgacg 17221 ccggccgtga attccagtac cgcaacgacc agttgatgta cgtcgccgac ggcgccgtgg 17281 agatcgaggc ggagggccgc gcctatcgcc tgggccgcgg ggactccctg tacctcaccg 17341 gcggggtgcg gcaccgctgg cgggcgaccg tgccggacac gcgcgtggtc gtcgtcgcgg 17401 tcgcggagca catcgaggcg gtccggaacc ggcctgggcg ctgatgcgcg tcgtctccct 17461 ggtgccgtcg ttgaccgagg ccgtcgcgga cctcggtgtg ctggtcggcg cgacggactg 17521 gtgcagccac ccggccgacc tggacgtcac gcgcgtgggc ggcaccaaga acccgaaggt 17581 ggaccgcgtc ctcgccctcg cccccgacct ggtgatcgcc aacgaggagg agaaccgcga 17641 gcccgacctc gccgccctgc gcgcggccgg cgtcgacgtc ctggtgacgg aggtgcggga 17701 cgtgccgcag gccttcggtg aactcgcgcg tgtcctggag gcctgcgggg tgaccgcacg 17761 cccgcgctgg ctggacgagg cggaggacgc ctggtcgtcg ccggccccgg accgccgtac 17821 gacagccgtc gtgccgatct ggcgccgccc gtggatggtg ctgggccgcg acaccttcgc 17881 gggcgacgtg ctggcccgcc tgggcgtgga ccacgtctac accacgcacg aggaccgcta 17941 cccccgtata cccctggacg acctgcggga ggcggccccc gacctcgtcg tcctccccga 18001 cgagccgtac cgcttcaccg ccgacgacgg cccggaagcc ttccccggac tgccctgcgc 18061 gctggtcagc gggcggcacc tgacgtggta cggcccgtca cttgccgagg caccacgggt 18121 actgacggcg gccctgcgag cagcgcaccg ctgaacagcc cccgggtggt gtgtacggcg 18181 gcgacacccc aggccgcgac gaggacgacg tacagcccga cggcgagccc ttcgtagacg 18241 acgagcccgg tgtgccgggc cagcgccgtg gcaccggtga cacaggtgcc gacgggaaag 18301 gtgaacgccc accaggtcat cgcgaacccc atgccgtgcc ggcgggcccg caggacatgg 18361 gcggtggcga gcccgaacca cagcagcgcg aaacccatga cggggacgcc gtacagcacg 18421 gccagcatcc cgaagccctc gctgtacggc gccgggacca cgcccggcgc gacgtccgcg 18481 aagacgccga ccgcggtggt ggactggccg agcggcccca gcacgagaaa cagcgacggg 18541 gtgaggacga ggggcagcgg cccgcccgtg atcagccggg cgaacaccag gggcagcatc 18601 agcagcgtcg cgagcagact cagcccgaac atcgcgacac aggccagcag cagcgtctcc 18661 cgggcctgcc ccgccggcag atgcggcacg agcagcggcc ctagcgccgc ggacaccatg 18721 ggcgcgacca gcggcagcag ccagacgggc gtggcctcgg acggctcgac gcgatggcgt 18781 acggccatga ggtacgggac ggcgacggcg gccgccagcc cgatggccgt ccccgcggcg 18841 aacagcacgg cgtccagagc gaccgccgcc gaggtcccga tccagtccct gccgacgacg 18901 agggcaccgc cgccgacggc cagcagggcc atggacagac agccgtagaa gggcgccatg 18961 gccgggtcga ggaggtgggc gcgggcctgg tcgcggtggt gcgaccagtg cgcggcgcgg 19021 gcgccgagca gcgtgacgag cagggcgagg gacagggccc acacggcggc gcagacggtg 19081 cgcagaccgg ggaggtggag cggcagtccg gcgccggcgg tggccacggc ggctgtgccc 19141 atgacggcgg cgtaccagtt gggtccgagg tgacggacgc ccaggcggcg ggttggcccg 19201 aggtgacggg ctgcggtgac catgtgtcca gcgtcgcttc gcggattccc tcccaccagg 19261 gagtttgcct ctatggcgac ataaactgaa cttatgacag aggtggcgga ggggcagttt 19321 cgcgcggggt ccttgtcaca ccgcgtcccg gagctcggcg cgctggaact gctgctcgcg 19381 gtggcgcggc tcggcagtct cggcggggcg gcgcgtgagc tggggatcac ccagcccgcg 19441 gcgagcagcc ggatccggtc gatggagcgg cagttggggg tggcgctggt cgatcgctca 19501 ccacggggtt cgcggctgac ggacgccggg gcgctggtga cggactgggc gcggcggatc 19561 gtggaggcgg cggaggcgtt cgacgcgggg gcgcaggcgc tgcgggaccg gcgggactcg 19621 cggctgcggg tggcggcgag catgacgatc gcggagtatc tgctgccggg ttggctgctt 19681 gccctgcggg cgcagcggcc ggatacggcg gtgtcgttgc tggccgggaa ctcggcggcg 19741 gtggcggagc ggttgctggc cgacgaggcg gatctcgggt tcgtggaggg ggtgtcggtg 19801 cctacggggc tggactccgt ggtcatcgcc cacgacaacc tgatcgtggt gacggcgccg 19861 gggcatgtgt gggcgcgtcg gcggcgggcg ctgtcggggg cggagctggc ggccacgccg 19921 ctgatcctgc gggaggaggg gtccgggact cggcaggtgc tggattcggc gctggggggt 19981 ctggcgcggc cgctgatcga gctgtcctcg acgaccgcgg tcaaggccgc ggcggtgggt 20041 ggggccgggc cggcggtgct gagtgagctg gcggtggggg aggagctgtc gatgcggcgg 20101 ctggtgagcg tgccgctggc cgacgtgtcg ctggcgcggg atctgcgggc ggtgtggcct 20161 acggggcatc ggccggtggg gcctgcgcgg gatctgttgg cgttgacgcg ggggtgaggc 20221 tggtttttct cgcccccgcc gcccctaccc attcccgtcc cccgggggct gccgcccccg 20281 gacccccgca tcggccctga acgggcctcg tcctcaaacg ccggacgggc tgaaaagcct 20341 cacccgccgt cgcgagctga gaaacccggc ctcagccacc agccgcccgc accaaccccc 20401 gcacaacccg caaatcctcc cccatctccg gatgccactg cacccccaac acccaccccg 20461 ccgaaggcag ttccaccgcc tccacggtcc cgtccaccgc gtacgccgac gcgacgagcc 20521 cctcacccaa ccggtccacg gcctgatggt gataggtcgg cacggacgac tcctccggga 20581 cgagaccggc gtacagactc cccggcaccg gcttcacggt atggctgccg aacaccccga 20641 cgacctccgc gtgcccgtcg atgtgctgaa cgagcgtccc cccgagggcg acgttcagca 20701 gctgcatccc ccggcagatc cccagcaacg gcacccccgc gtcgagtgcc gcgtcgatga 20761 gcgccagctc ccacgcgtcc cgctcccgcg ccgcaggccc cgtacgaggc tcccgctccg 20821 cgccgtaccg gaccggctcg acgtcggggc cgccggcgat gaccagcccg tccagccggg 20881 cgacggccgc cgcggcatgg gccgggtcgt ccggcggcag catcgcggcc aggccgcccg 20941 cccgctgcac cagccgcgga tagccggccg gcagcagcgc cgcgtccagc tcccacacgc 21001 cccagcgcgc accggactcc agataggtgc tgaccccgat c //