LOCUS NZ_BNBM01000011 21008 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence11, whole genome shotgun sequence. ACCESSION NZ_BNBM01000011 VERSION NZ_BNBM01000011.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 315152) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 50427 Orig. end :: 71435 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000011.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..21008 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="1" /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /tool="antismash" cand_cluster 1..21008 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" protocluster 1..21008 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:11008](-)" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core complement(10001..11008) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" misc_feature 689..705 /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 16.21" /tool="antismash" gene 704..2281 /locus_tag="IE325_RS26920" /old_locus_tag="GCM10018780_54460" CDS 704..2281 /GO_function="GO:0016491 - oxidoreductase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) DAO" /gene_functions="biosynthetic-additional (smcogs) SMCOG1222: dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015662859.1" /locus_tag="IE325_RS26920" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54460" /product="NAD(P)/FAD-dependent oxidoreductase" /protein_id="WP_190072660.1" /sec_met_domain="DAO (E-value: 1.2e-08, bitscore: 29.1, seeds: 521, tool: rule-based-clusters)" /transl_table=11 /translation="MPAHEGTPGHRTYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLD HTGGAAVSTRPFAGIDARLSRYSYLVSLLPKKIVRDLGLDFRIRTRDVSSYTPVERDGH STGLLVGGGERRTREAFERLTGGEREYAAWQRFYGMTGEVARRVFPTLTEPLPSREELR RRVDDEDAWRILFEEPIGVAIEDRFTDDLVRGVVLTDALIGTFADAHDTSLKQNRCFLY HVIGGGTGDWDVPVGGMGALTDALATAARDAGAVIVTGHEAVRIDTDGRTAEVSFRTAD GEGVAAARHVLVNASPQDLAALTGDTPPAPAEGAQLKVNMLLKRLPRLRDSSVDPREAF SGTFHIAEGYDQLAAAHAQAAAGELPAAPPSEIYCHSLTDPTILAPDLVEQGYQTLTLF GLHTPARLFAHDNDAVREELLKSTLAQLDAHLAEPIADCLATDADGRPCIEAKTPLDLE RDLRLPGGNIFHRDLAWPYAQEGTGRWGVETPHANVLLCGAGAVRGGGVSGVPGHNAAM AVLEAEQS" gene complement(2286..4049) /locus_tag="IE325_RS26925" /old_locus_tag="GCM10018780_54470" CDS complement(2286..4049) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1053: beta-lactamase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007379876.1" /locus_tag="IE325_RS26925" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54470" /product="serine hydrolase domain-containing protein" /protein_id="WP_190072661.1" /transl_table=11 /translation="MTDEVIPRLTRRQLGTLALGGALAIAPLPAGPAAATENARRTTLR HGSPERAGLLPSHLRQLVTDAEAFLGPSPKYPWYAGAVLLAGRGGTVALHEPIGMAVRY AAYDEKTDTGVEFPADQQLPMSQDTVFDLASVSKLFTSILAVQQIERGNLGLEAKVASY LPDFGRAGKQDITIRQLLTHTSGFRPWIPLYAAPTYEEKLQLIWNEAPLNPPGTAYLYS DLNLISLQLVLEEITGRSLDTLLHEDITGPLGMRRTRYNPPAAWKPRIAATEDARKPWS GLDRGLVWGDVHDENAFSLGGVAGHAGVFSNAWDLAVLGRTLLNGGAYGRSRILEPESV DLMFTDFNTNFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSLVLDPTTDSFLIV LGNSVHPVRSWRTGSAPRVAAANNMARAVPVRPRHGRTAWFSGMATATTATLALPALDT FGGDARLCCALWWDTEPQADGLTLEATTDGTTWQPLPFTTSRHGEPPQAHPTGTVTGWS GRVWHRLTARLPEHRQLTLRWRYSTDRLYVGRGGYVDGLRVERADTVLFDEARPADAAR ISASGWTASAD" misc_feature complement(3966..3968) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 4180..5289 /locus_tag="IE325_RS26930" /old_locus_tag="GCM10018780_54480" CDS 4180..5289 /EC_number="1.13.12.-" /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004003890.1" /locus_tag="IE325_RS26930" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54480" /product="nitronate monooxygenase family protein" /protein_id="WP_190072662.1" /transl_table=11 /translation="MQTELSNKLGIEHALFGFTPFPAVAAAISRAGGFGVLGAVRYTAP DDLKRDLDWIEAHVDGRPYGLDVVMPAKKVEGVTEADVEAMIPEGHRQFVQDTLAKYGV PELAEGEASGWRITGWMEQVARTQLDVAFDYPIKLLANALGSPPADVVERAHDRGVLVA ALAGSARHARKHKEAGIDIVVAQGYEAGGHTGEIASMVLTPEVVEAVDPLPVLAAGGIG SGQQVAAALSLGAQGVWLGSIWLTTTEADMHSPGLTAKLLAAGSGDTVRSRALTGKPAR QLRTEWTDAWDDPNGPGTLPMPLQGLLVADAVSRIQKYEVAPLLGTPVGQIVGRMNSER TVQAVVDDLTRGFEQAVDRINRIAGRSGQ" gene 5286..6863 /locus_tag="IE325_RS26935" /old_locus_tag="GCM10018780_54490" CDS 5286..6863 /NRPS_PKS="Domain: AMP-binding (16-420). E-value: 3.5e-76. Score: 248.3. Matches aSDomain: nrpspksdomains_IE325_RS26935_AMP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007503544.1" /locus_tag="IE325_RS26935" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54490" /product="acyl-CoA synthetase" /protein_id="WP_190072663.1" /sec_met_domain="AMP-binding (E-value: 1.7e-80, bitscore: 264.7, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MTSTSAAHAVSTPPVGFWAQATADPDRTVLVAPDGEAWTAGRLHE ATNRLVHGLRTAGLRRGDAFAVVLPNGVEFFTAYLAASQAGFYLVPVNHHFVGPEIAWI VADSGAKVLIAHERYAEPARQAAEEAGLPADHRYAVGEVEGFRPYAELLEGQPESAPDD RTLGWVMNYTSGTTGRPRGIRRPLSGKLPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYH TAVLQFAGASLHIGHRLVLMDKWTPEEMLRVIDTHKCTHTHMVPTQFHRLLALPEGIRA SYDVSSMRHAIHGAAPCPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTV GKAWPISELAVFDDDGNRLPPGELGTVYLKMNTGGFAYHKDEAKTKKNRIGDFFTVGDL GYLDEDGYLFLRDRKIDMIISGGVNIYPAEIESVLLAHPAVADAAAFGIPHDDWGEEVK AVVEPAPGHEPGPDLAAAVLDHCAGQLAGYKRPKSVDFITEMPRDPNGKLYKRRLRDPY WEGRTRPV" aSDomain 5334..6545 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS26935_AMP-binding.1" /evalue="3.50E-76" /label="IE325_RS26935_AMP-binding.1" /locus_tag="IE325_RS26935" /protein_end="420" /protein_start="16" /score="248.3" /specificity="substrate consensus: X" /tool="antismash" /translation="FWAQATADPDRTVLVAPDGEAWTAGRLHEATNRLVHGLRTAGLRR GDAFAVVLPNGVEFFTAYLAASQAGFYLVPVNHHFVGPEIAWIVADSGAKVLIAHERYA EPARQAAEEAGLPADHRYAVGEVEGFRPYAELLEGQPESAPDDRTLGWVMNYTSGTTGR PRGIRRPLSGKLPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYHTAVLQFAGASLHIGHR LVLMDKWTPEEMLRVIDTHKCTHTHMVPTQFHRLLALPEGIRASYDVSSMRHAIHGAAP CPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDG NRLPPGELGTVYLKMNTGGFAYHKDEAKTKKNRIGDFFTVGDLGYLDEDGYLFLRDRKI DMIIS" CDS_motif 5799..5834 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE325_RS26935_0001" /evalue="5.00E-04" /label="NRPS-A_a3" /locus_tag="IE325_RS26935" /protein_end="183" /protein_start="171" /score="13.1" /tool="antismash" /translation="YTSGTTGRPRGI" gene complement(6888..9797) /locus_tag="IE325_RS26940" /old_locus_tag="GCM10018780_54500" CDS complement(6888..9797) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003982044.1" /locus_tag="IE325_RS26940" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54500" /product="AAA family ATPase" /protein_id="WP_190072664.1" /transl_table=11 /translation="MAHGLRQPTTEHRPLLERDRELKAIDSALSGLRDAVDGVSRAPRG GLLAFTGAAGLGKTTLIAATRARAAALGLTVISGTGGEKEQGLAFRVVRQVLQPTLATM GETERREFLGSWYGIVGAALGLEATDSTQMPDPTGVRDGLDWVMTRLTVMNAPVVLLLD DLHWADAESLDWLASFAPRVADLPLLMVAAYRPDDLPPDATSFRTLVERHEERPHALSP LGRDGVARIVRNEVGEEAEDVFCGECWTATGGSPFEAVELAIRLRERRVKGTQDELPVI GDLAAAVKGPGLIERLHRLGTSTVRFAWAAAVLGGSFSPELAAGIAVVGNEDAAEATRK LRASRILADGEGPGRSLAFVHPSIATTIYHDIPSGLRVGMHNAAADAAQAAGFGPTAAA RHLLEVPCDGRPEAVLVLRAAAREYLRAGAPEAARRVLTRALREPPPAEDRAALLHELA CSTFLIEPTATVSHLQEALAEPGIDPELRASIVYRLAQALANTDRLTEAAAVAADEARR APNPRIKLRMQADHFVWSAFRADEPDSSARSRRLARLADKLTGRGLEERYILGLRAWDA LVRGEPRQTALRHAEEALRGGMSWTDENRGFEVPVAVALLFMYCDQPWRAEDLFTKGMA ECEHKGWSGSHLAQGQTLSGYIRYRRGCLSEAEEFVRAGLHTAERVEGAVPAQWFAIGI LIQILLARGRTEDARELADAHHYGDVVPNAVIFPDPRTVYAELLLAEERYAEAARLLSA VGDWLESRNWRNPAWCPWQLDLASALARTAPEKAVRHAQDAVKRARDFGAASAIGQALS VEAEVTGGPAALDLHAEAVEYLERSPASYELARALVGHGAALSRNGRVQEAAHRLYQGL ESAVHCGAEGLAVRARQELSAAGLRPLPLRYAQTDTLTTRERQTAELTVQGQPEAVIAK ELRLTEQGVRQLLSCVYRKIGTDAAGLAQALETFPCPRT" misc_feature 9790..9805 /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 19.9" /tool="antismash" misc_feature complement(9876..9891) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 21.64" /tool="antismash" gene complement(10001..11008) /locus_tag="IE325_RS26945" /old_locus_tag="GCM10018780_54510" CDS complement(10001..11008) /EC_number="4.2.3.162" /GO_function="GO:0016829 - lyase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0016114 - terpenoid biosynthetic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) terpene: T1TS" /gene_functions="biosynthetic-additional (smcogs) SMCOG1052: Terpene synthase/cyclase metal-binding domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010048704.1" /locus_tag="IE325_RS26945" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54510" /product="(-)-alpha-amorphene synthase" /protein_id="WP_229912061.1" /sec_met_domain="T1TS (E-value: 7.6e-60, bitscore: 197.5, seeds: 237, tool: rule-based-clusters)" /transl_table=11 /translation="MSTTHEEIAVAAPRGIPALNLRELIDTNLYMPFPFQSNPHASEAA VGVENWLRTWGLTDDPAVAAMISYTRPAELAAYNSPAVDSGLLQIMANQIAYQFIFDDQ AEDIGLQRPGRLLPMLSESVRILRDGQPPDTALGAALADLQRQVQERCTPAQAARWAWN SREYVHGLLHEAVAQSHSAPLGSGLCRSIRSLIAGIEPFHPLCEAAQPYELAPEVLRHP VVRRLGRLSVDAAVWIADLFSAVKEQRAGGVINLALDYQRAHQCSLPEAVRLAIRRINS TIGEYEELYDEIRPELSPSGVGYVDGMGGWIPGCYFWSRTVPRYADTMAASAVP" gene complement(10992..12476) /locus_tag="IE325_RS26950" /old_locus_tag="GCM10018780_54520" CDS complement(10992..12476) /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /GO_function="GO:0005506 - iron ion binding [Evidence IEA]" /GO_function="GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1034: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003982041.1" /locus_tag="IE325_RS26950" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54520" /product="cytochrome P450" /protein_id="WP_190072666.1" /sec_met_domain="p450 (E-value: 9.1e-72, bitscore: 236.3, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MSRIVPDSGHTWRVGVAPGIFPTVAHGIALFRRPLDFLNSLPAHG DLVEVRLGPLRAWVVCHPELVHQVLMDARTFDKGGPLYDRLRTLLGDGVGTCPHQAHRR QRRLLQPGFRKARVADQTELMGEEVESVCREWRAGQEVDVSAAMLTLSARVIGRVLFSD SLDATTAAEVHSCLVTIVRGLFLRTVVPVDALFRVPTPANRRFRDASERLRAIVDTAIA ERLRGTPPSDRDDLLDVLLSAARSEGEAAAITEQEVRSQALTLIFAGAETTALCLASAF DLLARHPEDERRLHSEVDTVLADGRPPGRDELPRLVHTRRVVTETLRHRPPGWLFTRVT TKETALAGQRLPRGATVLYSPYLLHHDPASFPDPDRFLPDRWRPERAVAVPPGAMIPFA AGTRNCIGETFAMAEATVAVAFIARHWRLRHLPGHVARLRPAASLGPRGLVMVCEPRAQ RPPATPPRATSLAPRATVTPVVHDPGTAGGDGVHDA" misc_feature complement(12354..12356) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene complement(12700..15117) /locus_tag="IE325_RS26955" /old_locus_tag="GCM10018780_54530" CDS complement(12700..15117) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_process="GO:0017000 - antibiotic biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009313531.1" /locus_tag="IE325_RS26955" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54530" /product="penicillin acylase family protein" /protein_id="WP_190072667.1" /transl_table=11 /translation="MRTTRLRRLVVGAVALLTASAALPAGAAERPGHQERPSHGGLSAV IRYTEYGIPHIVAKDYKSLGFGTGWAQAADQVCTLADGFVTVRGERSRFFGPDAASDSA LSSATSNLAGDLYFRGLRQTRTVEKLLAEPAPRGPSRQVKDLMGGFAAGYNAWLRHKQI TDPVCRGAMWVRPITSLDVAIRFYALSVLGGQGGAVDEITSARPPTETAPGAKDTAPDA EALIRAVRKRTADAAMGSNAVAFRGDTTANGRGLLLGNPHYPWQGGRRFWQAQQTIPGE LDVAGAALLGAPTIAIGYNSHVAWSHTVSTGVPFSLHQLTLDPADPTVYLVDGGRERMT KRTVTVAVKDGAPVTRTQWWTRYGPVAASVGGELPLPWTASTAYAFNDPNAANLRFADT SLGFGKARGTADIVRSLTRNQGLPWVNTIAADSSGHSLYTQSQVLPRITDDLAARCFTG LGRTTYPAAGIAVLDGSRGECALGSDADALQGGIFGPARMPTLKDAPYVENSNDSAWLT NADRPLTGYERVFGSIGTQRSLRTRGAIEDVTAMAERGGLTVRDLERQQFANRVPAGDL VAADAAKACAALPGGTATGSDGKAVDVSGACPVLAAWDRTMDTGSRGALLFDRFWRKLS AKVPAAQRWKVPFSAADPVGTPNTLNTGAPGFATALADAVAELRAAGIALDSRLGEHQV VVRNGQRIPVHGGTEGMGVWNKIEPEWDQARGGYTEVTSGSSHIQAVGWDGSRCPVART LLTYSQSSSTRSPHFSDQTRLFSGEKWVTARFCEKDVLSSPVLRVVRVSEHG" misc_feature complement(15049..15051) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 15227..16726 /locus_tag="IE325_RS26960" /old_locus_tag="GCM10018780_54540" CDS 15227..16726 /NRPS_PKS="Domain: AMP-binding (13-404). E-value: 3e-98. Score: 321.0. Matches aSDomain: nrpspksdomains_IE325_RS26960_AMP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015662872.1" /locus_tag="IE325_RS26960" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54540" /product="acyl-CoA synthetase" /protein_id="WP_190072668.1" /sec_met_domain="AMP-binding (E-value: 1.1e-101, bitscore: 334.4, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MTQGQGSTVDGVLRRSARRTPARTAVEYGDRTWTYEELDQAVSRA ASVLLDQGLAPGDRVGSYGHNSDAYLIGFLACARAGLVHVPVNQNLTGDDLAYIVGQSG AALVLTDPDLAGRLSEDVRTLPLRDAEDSLLARLATAPEYDGPEPRSEDLVQLLYTSGT TALPKGAMMTHRALVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATN IILDAPDGDRLFDLIEAGRVDSLFAPPTVWIGLAGRPDFAERDLGGLRKAYYGASIMPV PVLERLRERLPKLGFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEQG VEVPDGTSGEIVYRSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVK DVINSGGVLVASRQVEDALYTHEGVAEVAVIGLPDERWIEAVTAVVVPRGEVGEAELIE HAREKLAHFKAPKRVVFVDELPRNASGKILKRELRDRFADN" aSDomain 15266..16438 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS26960_AMP-binding.1" /evalue="3.00E-98" /label="IE325_RS26960_AMP-binding.1" /locus_tag="IE325_RS26960" /protein_end="404" /protein_start="13" /score="321.0" /specificity="substrate consensus: Leu" /tool="antismash" /translation="RRSARRTPARTAVEYGDRTWTYEELDQAVSRAASVLLDQGLAPGD RVGSYGHNSDAYLIGFLACARAGLVHVPVNQNLTGDDLAYIVGQSGAALVLTDPDLAGR LSEDVRTLPLRDAEDSLLARLATAPEYDGPEPRSEDLVQLLYTSGTTALPKGAMMTHRA LVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATNIILDAPDGDRLFD LIEAGRVDSLFAPPTVWIGLAGRPDFAERDLGGLRKAYYGASIMPVPVLERLRERLPKL GFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEQGVEVPDGTSGEIVY RSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVKDVINS" CDS_motif 15695..15748 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE325_RS26960_0001" /evalue="2.70E-06" /label="NRPS-A_a3" /locus_tag="IE325_RS26960" /protein_end="174" /protein_start="156" /score="20.0" /tool="antismash" /translation="LLYTSGTTALPKGAMMTH" CDS_motif 16256..16345 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE325_RS26960_0002" /evalue="8.40E-08" /label="NRPS-A_a6" /locus_tag="IE325_RS26960" /protein_end="373" /protein_start="343" /score="24.6" /tool="antismash" /translation="PDGTSGEIVYRSPQLCEGYWDKPEETAEAF" gene complement(16745..18040) /gene="paaK" /locus_tag="IE325_RS26965" /old_locus_tag="GCM10018780_54550" CDS complement(16745..18040) /EC_number="6.2.1.30" /GO_function="GO:0047475 - phenylacetate-CoA ligase activity [Evidence IEA]" /GO_process="GO:0010124 - phenylacetate catabolic process [Evidence IEA]" /NRPS_PKS="Domain: AMP-binding (84-335). E-value: 1.1e-22. Score: 72.1. Matches aSDomain: nrpspksdomains_IE325_RS26965_AMP-binding.1" /codon_start=1 /gene="paaK" /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007503538.1" /locus_tag="IE325_RS26965" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54550" /product="phenylacetate--CoA ligase PaaK" /protein_id="WP_190072669.1" /sec_met_domain="AMP-binding (E-value: 7.9e-30, bitscore: 97.8, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MADATELLDSGERLAPEALRELQLERLRRSLRHAYDNVPFYRESF DKAGVHPDDCRSLGDLARFPFTTKADLRQNYPYGMFAVPQDRIRRIHASSGTTGRPTVV GYTDADLSLWSDMVARSIRAAGGRPGDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPAS GGMTARQVQLIQDLRPEIIMVTPSYMLTLLDEFERQGVDPRGTSLRVGIFGAEPWTERM RREIEERFAIDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFFPEIVDPITGEVLPE GEEGELVFTSLTKEAMPVIRYRTRDLTRLLPGTARVFRRMEKITGRSDDMVILRGVNLF PTQIEEIVLRIPGVAPHFQLRLTREGRLDALTVRAEARPDASQETRDAAAQAIAAAVKD GIGVSVAVEIVEPESLERSVGKIRRIEDLRPR" CDS_motif complement(17006..17068) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE325_RS26965_0001" /evalue="3.60E-04" /label="NRPS-A_a8" /locus_tag="IE325_RS26965" /protein_end="345" /protein_start="324" /score="13.3" /tool="antismash" /translation="TGRSDDMVILRGVNLFPTQIE" aSDomain complement(17036..17788) /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS26965_AMP-binding.1" /evalue="1.10E-22" /label="IE325_RS26965_AMP-binding.1" /locus_tag="IE325_RS26965" /protein_end="335" /protein_start="84" /score="72.1" /specificity="substrate consensus: X" /tool="antismash" /translation="QDRIRRIHASSGTTGRPTVVGYTDADLSLWSDMVARSIRAAGGRP GDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDLRPEIIMVTPSY MLTLLDEFERQGVDPRGTSLRVGIFGAEPWTERMRREIEERFAIDAVDIYGLSEVIGPG VAQECVETKDGLHVWEDHFFPEIVDPITGEVLPEGEEGELVFTSLTKEAMPVIRYRTRD LTRLLPGTARVFRRMEKITGRSDDMVILR" gene 18222..19076 /locus_tag="IE325_RS26970" /old_locus_tag="GCM10018780_54560" CDS 18222..19076 /NRPS_PKS="Domain: Abhydrolase_1 (21-265). E-value: 1.7e-29. Score: 95.1. Matches aSDomain: nrpspksdomains_IE325_RS26970_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036: alpha/beta hydrolase fold protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016433338.1" /locus_tag="IE325_RS26970" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54560" /product="alpha/beta fold hydrolase" /protein_id="WP_190072670.1" /sec_met_domain="PF00561 (E-value: 6.7e-27, bitscore: 88.8, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-20, bitscore: 68.0, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MPTFRAADGTEIAYHLRGEGEPLLVLPGGPMRASGYLGDLGGLAA HRQLVLLDLRGTGDSAEPEDPATYRCDHMVDDVEILRAHMGRAHMDVFGHSAGGSLAML YAARYPERVARLVLVTATPWALGMLPTVEDRLAAARLRKGEPWFAEALAAFEAWLTGAG DFDPVFAPFFYGRWDDAAKQHDARGDAEYNDEASGIYGSAGAFDPPRTSTELSRLTAPT LVLAGELDGSPDPDLARRTADVFPNAEIAVQPGAGHHPWLDGPEWFVRRVAAFLDGTGL GTG" aSDomain 18285..19016 /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS26970_Abhydrolase_1.1" /evalue="1.70E-29" /label="IE325_RS26970_Abhydrolase_1.1" /locus_tag="IE325_RS26970" /protein_end="265" /protein_start="21" /score="95.1" /tool="antismash" /translation="PLLVLPGGPMRASGYLGDLGGLAAHRQLVLLDLRGTGDSAEPEDP ATYRCDHMVDDVEILRAHMGRAHMDVFGHSAGGSLAMLYAARYPERVARLVLVTATPWA LGMLPTVEDRLAAARLRKGEPWFAEALAAFEAWLTGAGDFDPVFAPFFYGRWDDAAKQH DARGDAEYNDEASGIYGSAGAFDPPRTSTELSRLTAPTLVLAGELDGSPDPDLARRTAD VFPNAEIAVQPGAGHHPWLDGP" CDS_motif 18498..18542 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_IE325_RS26970_0001" /evalue="1.40E-03" /label="NRPS-te1" /locus_tag="IE325_RS26970" /protein_end="107" /protein_start="92" /score="11.2" /tool="antismash" /translation="FGHSAGGSLAMLYAA" gene complement(19118..19540) /locus_tag="IE325_RS26975" /old_locus_tag="GCM10018780_54570" CDS complement(19118..19540) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003988819.1" /locus_tag="IE325_RS26975" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_54570" /product="hypothetical protein" /protein_id="WP_190072671.1" /transl_table=11 /translation="MKRRVHAICTTAITVLALAGPTAPAAYARGDLDCRDFTFQEDAQA EFDRGFSDPDRSGRDQGRNNGIACAHLPHRGSIVTPLPTLAPLPTRSAVPTQGVRGGLG GSSGPADVEVALGAGLAVGALALTAGFFVYRRRLNR" misc_feature 19655..19670 /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2, activator of antibiotic production, confidence: strong, score: 19.52" /tool="antismash" misc_feature complement(20451..20469) /note="TFBS match to LexA_variant_3, Repressor of DNA damage response, confidence: weak, score: 19.99" /tool="antismash" ORIGIN 1 tcggcccgca ccatcccgac acgctggtca cgcgctacga agtcgcctac gcgctcggcc 61 agttgggccg ctgggcggaa gccctgcaga cctacggcga ggtcgccgag gcccgtgccc 121 aggccctcgg ccccgatcac ccggacacgc tcgccgcccg ctacgaggtc ggcatcagcc 181 tcggccgcct gggccgcagc gcggaggcgc tccggctcta ccgcgacctc gtcgacgacc 241 ggacccgtgt ccacggcacc gcccaccccg agaccctgcg cgcccgccac ggcctcggcg 301 tcaacctcgg ccgcctcggc cgctgggagg aggccctcgc cgagtcccgc gacgtgtgcg 361 cgatccgtga gcgagtactg ggcgccgacc acccggacac cctggtcagc cgccgcgagg 421 tcgccgtgag cctcggctgg ctgggccgct ggcccgacgc gctcaccgag taccgcacgg 481 tggccgccgc ccgcgaacgc gtcctcggcg ccgaccaccc cgacaccctc gccagccgca 541 acgacgaggc ccactgcctc cagcagctgg ggcgggaggc ggaggcggtc gagctgtacc 601 ggagggtggc ggtgctgcgg cagcagcggg cgacgggcgg cccctgactc cggacgcgcg 661 cgcatctctg gcccacctag atcatcacgt gttacgaaga accatgcctg cacacgaggg 721 aaccccggga caccgtacgt acgacgccgt catcgtcggc ggagggcaca acggcctggt 781 cgccgccgcc tacctggccc gggccgggcg gtccgtgctg gtgcttgagc ggctggacca 841 cacgggcggt gccgccgtct ccacccggcc gttcgccggg atcgacgcac ggctgtcccg 901 ttactcctac ctggtcagcc tgctgccgaa gaagatcgtc cgggacctcg gcctggattt 961 ccggatccgc acccgcgatg tgtcctccta cacgcccgtg gaacgcgacg ggcactcaac 1021 cggactactg gtgggcggcg gcgaacggcg tacccgggag gccttcgaac gactgaccgg 1081 cggcgagcgc gagtacgcgg cctggcagcg cttctacggc atgacaggcg aggtcgcccg 1141 ccgagtcttc ccgacgctca ccgaacccct gcccagccgc gaggaactgc gccgccgggt 1201 ggacgacgag gacgcctggc gcatcctctt cgaggagccg atcggcgtcg cgatcgagga 1261 ccgcttcacc gacgacctgg tgcggggcgt ggtcctcacg gacgccctga tcggcacctt 1321 cgccgacgcc catgacacct cgctcaagca gaaccgttgc ttcctgtacc acgtgatcgg 1381 cggtggcacc ggcgactggg acgtccccgt cggcggcatg ggcgccctca ccgacgccct 1441 cgccacggcc gcgcgcgacg cgggggccgt gatcgtcacc gggcacgagg cggtacggat 1501 cgacaccgac ggccgtacgg cggaggtcag cttccgtacg gcggacggcg agggcgtcgc 1561 cgccgcccgg cacgtcctgg tgaacgcctc cccgcaggac ctggccgccc tcaccggcga 1621 cacgcccccg gccccggccg agggcgccca gctcaaggtg aacatgctgc tcaagcgcct 1681 gccccgattg cgcgacagct ccgtcgaccc gcgcgaggcg ttctccggca ccttccacat 1741 cgccgagggc tatgaccagc tggccgccgc ccacgcccag gccgccgccg gcgaactccc 1801 cgccgcgccc ccgtccgaga tctactgcca ctcgctgacc gacccgacca tcctcgcccc 1861 cgacctggtc gaacagggct accagaccct caccctcttc ggcctgcaca ccccggcgag 1921 gctcttcgcg cacgacaacg acgccgtacg cgaggaactc ctgaagtcga ccctcgccca 1981 gctcgacgcc cacctcgccg agccgatcgc cgactgcctg gcgaccgacg ccgacggccg 2041 gccttgcatc gaggcgaaga ccccgctcga cctggagcgc gacctgcgcc tgcccggtgg 2101 caacatcttc caccgcgacc tcgcctggcc gtacgcccag gaaggcacgg gccgttgggg 2161 cgtggagacc ccgcacgcga acgtgctgct gtgcggggcc ggcgcggtgc gcggaggagg 2221 ggtgagcggg gtgcccggac acaacgcggc gatggcggtg ctggaggcgg aacagagctg 2281 agccgtcagt ccgccgacgc cgtccagcca ctcgcgctga tccgcgccgc gtccgccggc 2341 cgggcctcgt cgaagaggac ggtgtccgct ctctccacgc gcagcccgtc gacgtacccg 2401 ccccggccca cgtacagccg gtcggtgctg tacctccagc ggagcgtcag ctgccgatgc 2461 tcgggcagcc gtgccgtgag ccggtgccaa acgcggccgg accagccggt gaccgtgccg 2521 gtcgggtggg cctgcggcgg ctcgccgtgg cggctcgtcg tgaacggcag cggttgccag 2581 gtggtgccgt cggtcgtcgc ctccagggtg agcccgtccg cttggggttc ggtgtcccac 2641 caaagtgcgc agcacagccg cgcgtcgcca ccgaacgtgt cgagcgcggg gagcgcgagg 2701 gtcgcggtcg tggcggtcgc catgcccgag aaccatgccg tacgaccgtg tcgtgggcgt 2761 acgggcacgg cgcgcgccat gttgttggcg gcggcgaccc ggggcgccga gccggtccgc 2821 caactgcgca ccgggtggac cgagttgccc agcacgatca ggaacgagtc ggtcgtgggg 2881 tcgaggacga gcgaggtgcc ggtgaagccg gtgtgtccgg cggtgcgcgg ggtcgccatc 2941 gcgcccatgt accagtgctg gtagagctcg aaaccgaggc cgtgctcgtc gccggggaag 3001 ttggtgttga agtcggtgaa catcaggtcg accgactccg gctcgaggat gcgggagcgg 3061 ccgtaggcac cgccgttgag cagcgtcctg ccgaggaccg cgaggtccca cgcgttcgag 3121 aacacgcccg cgtggcccgc gaccccgccg aggctgaagg cgttctcgtc gtgcacatcg 3181 ccccagacga gaccccggtc aaggcctgac cagggtttgc gggcgtcctc ggtggcggcg 3241 atcctcggct tccaggcggc gggcgggttg tagcgggtgc ggcgcatgcc gagcgggccg 3301 gtgatgtcct cgtggaggag cgtgtccagg ctgcggccgg tgatctcctc caggaccagc 3361 tggagggaga tcaggttcag gtccgagtag aggtacgcgg tccccggcgg gttcagcggc 3421 gcctcgttcc agatgagctg gagcttttcc tcgtacgtcg gcgctgcgta cagcgggatc 3481 caggggcgga accccgaggt gtgggtgagg agctgacgga tcgtgatgtc ctgcttgccc 3541 gcgcgaccga agtcggggag gtacgaggcg accttcgcct ccagccccag gttgccccgc 3601 tcgatctgct gtacggcgag gatcgaggtg aacagcttgg agaccgaggc cagatcgaag 3661 acggtgtcct gagacatggg cagctgctgg tcggccggga actcgacgcc ggtgtcggtc 3721 ttctcgtcgt acgccgcata gcgcaccgcc atgccgatcg gctcgtgcag cgccacggtg 3781 ccgccacggc cggcgagcag cacggcgccc gcgtaccagg ggtacttggg ggaggggccc 3841 aggaacgcct cagcgtcggt gacgagttgg cggaggtgag aggggaggag gcctgcacgt 3901 tcgggggagc cgtggcgcaa ggtggtacgg cgggcgttct cggtggcggc cgccggtcct 3961 gcgggtaagg gggcgatggc cagggcgccg cccagggcca gggttcccag ctgacggcgg 4021 gtaagtctcg ggatcacctc atcggtcatc gtgaaacctt gctgtcgggg ggtggccgtg 4081 tcaatgaggc gtgcgtgccc cgtcccaggg gcggcagaaa actgacggag catcagaaag 4141 ccccttccct cctccggagg actccggcat cctgcgccca tgcagacgga gctgagcaac 4201 aaactgggaa tcgagcacgc ccttttcggc ttcacgccgt tccccgccgt cgccgcggcc 4261 atcagccggg ccggcggttt cggagtgctc ggcgcggtcc gctacaccgc ccccgacgac 4321 ctcaaacgcg acctcgactg gatcgaggca catgtcgacg ggcggcccta cggcctggac 4381 gtcgtcatgc cggcgaagaa ggtggagggc gtcaccgagg ccgacgtgga ggcgatgatc 4441 cctgaggggc accggcagtt cgtccaggac actctcgcca agtacggcgt gcccgaactc 4501 gccgaggggg aggcctccgg ctggcgtatc accggctgga tggagcaggt cgcccgcacc 4561 cagctcgacg tcgccttcga ctaccccatc aagctgctcg ccaacgccct cggctcaccg 4621 cccgctgacg tcgtggagcg cgcccatgac cgcggtgtcc tcgtcgccgc gctcgcgggc 4681 agcgcccggc atgcccgcaa gcacaaggag gcgggcatcg acatcgtcgt cgcccaggga 4741 tacgaggccg gcggccacac cggtgagatc gcctccatgg tgctcacccc cgaagtggtg 4801 gaagcggtcg acccgctgcc cgtgctcgcg gccgggggca tcggcagcgg ccaacaggtg 4861 gctgccgcgc tcagtctcgg cgcccagggt gtgtggttgg gctccatatg gctgaccacc 4921 acagaagccg atatgcactc acccggcctg acggcgaagc tgctcgccgc cggctccggc 4981 gacaccgtcc gctcccgggc cctgaccggg aagcccgcac gccagctgcg caccgagtgg 5041 accgacgcct gggacgaccc gaacggaccc ggcaccctcc ccatgcccct ccagggactc 5101 ctcgtggccg acgccgtctc ccggatccag aagtacgagg tcgcaccgct gctcggcaca 5161 cccgtcggcc agatcgtcgg ccgtatgaac agcgaacgca ccgtccaggc cgtcgtcgac 5221 gacctcaccc ggggcttcga gcaggccgtc gaccgcatca accgcatcgc cggaaggagc 5281 ggccagtgac cagcacctcc gccgcacacg ccgtcagcac cccgcccgtg ggcttctggg 5341 cccaggccac cgccgacccc gaccgcacgg tcctcgtcgc gcccgacgga gaggcctgga 5401 ccgcaggacg cctgcacgag gccaccaacc gcctagtgca cggcctgcgc acggcgggcc 5461 tgcggcgcgg cgacgccttc gcggtcgtcc tccccaacgg cgtcgagttc ttcacggcct 5521 acctggccgc gtcccaggcc ggcttctacc tggtccccgt caaccatcac ttcgtaggcc 5581 ccgagatcgc ctggatcgtc gccgactccg gcgccaaggt gctcatcgcc catgagcgct 5641 acgccgagcc cgcccgccag gccgccgagg aagcgggcct tccggccgac caccggtacg 5701 cggtcggcga ggtcgagggc ttccggccgt acgccgaact cctcgaagga caaccggagt 5761 cggcgcccga cgaccgcacc ctcggctggg tcatgaacta cacctccggc accacagggc 5821 gcccccgcgg catccgccgc ccgctgtccg gcaaactccc cgaagaggcc tacctgggcg 5881 gcttcctcgg catcttcggc atcaaaccgt tcgacgacaa tgtgcacctc gtctgctcac 5941 cgctgtacca cacagcagtg ctccagttcg cgggcgcatc cctccacata gggcaccgcc 6001 tggtgctgat ggacaagtgg acgcccgaag agatgctccg tgtcatcgac acacacaagt 6061 gcacccacac ccatatggtc ccgacccagt tccaccgtct gctcgccctc ccggagggga 6121 tacgggccag ctacgacgtc tcctccatgc ggcacgccat ccatggcgcc gccccctgcc 6181 cggaccatgt gaagcgggcc atgctcgact ggtggggccc ctgtgtggag gagtactacg 6241 ccgcgagcga gggcggtggt gccttcgcga ccgccgagga ctggctgaag aagcccggca 6301 cggtgggcaa ggcctggccg atcagcgaac tcgccgtctt cgacgacgac ggcaaccggc 6361 tcccgccggg tgaactcggc accgtctacc tcaagatgaa caccggcggc ttcgcctacc 6421 acaaggacga ggcgaagacg aagaagaacc gcatcgggga cttcttcacg gtcggcgacc 6481 tcggctatct cgacgaggac ggctatctct tcctccgcga ccgcaagatc gacatgatca 6541 tctccggtgg ggtcaacatc tacccggccg agatcgagtc cgtcctgctc gcccacccgg 6601 ccgtcgccga cgccgccgca ttcggcatcc cccatgacga ctggggcgag gaggtcaagg 6661 ccgtcgtcga gccggccccc ggacatgaac ccggccccga cctcgccgcc gccgtactcg 6721 accactgcgc gggacagctc gccggctaca agcggcccaa gagcgtcgac ttcatcaccg 6781 agatgccgcg cgatcccaac ggcaagctgt acaagcggcg gctgcgcgat ccgtactggg 6841 aggggcgcac ccggccggtg tgatcgtggg cgcggggcgt cagcgggtca tgtccgaggg 6901 cacgggaagg tctccagagc ctgggcgagg cccgccgcgt cggtgccgat cttgcgatag 6961 acgcaggaca gcagctgccg cacaccctgc tcggtgagac gcagctcctt cgcgatcacc 7021 gcctccggct ggccctgaac ggtcagttcg gccgtctggc gttcccgagt ggtgagggtg 7081 tccgtctgtg cgtagcgcag cggcagcggt cgcagcccgg ccgccgagag ttcctgcctg 7141 gcccggacgg ccaggccctc ggcaccacag tgaaccgcgc tctccagccc ctggtagagc 7201 cggtgggcgg cctcctgcac ccgtccgttg cgcgacagcg cggcgccgtg ccccacgagc 7261 gcacgcgcca attcgtacga cgcgggggag cgctccaggt actcgacggc ctcggcgtgc 7321 agatcgagcg cggccggacc gccggtcacc tcggcctcga cggagagcgc ctgcccgatc 7381 gcggaggccg caccgaagtc ccgcgcccgc ttgacggcgt cctgagcgtg ccggaccgcc 7441 ttctcggggg cggtgcgggc gagagcggag gccaggtcca gctgccacgg acaccacgcc 7501 gggttgcgcc agttccgtga ctccagccag tccccgacgg cggacaacag ccgtgccgcc 7561 tccgcgtacc gctcctcggc caggagcagt tcggcgtaca ccgtgcgggg atcggggaag 7621 atcacggcgt tcgggaccac atcgccgtag tgatgggcgt cggcgagctc acgcgcgtcc 7681 tcggtccgcc cgcgggccag caggatctgg atgaggatgc cgatggcgaa ccactgggcg 7741 ggtaccgcgc cttcgacgcg ctcggcggtg tgcagcccgg cccgtacgaa ctcctccgcc 7801 tcggagagac agccgcgacg gtagcggatg tagccggaga gggtctgccc ctgcgccaga 7861 tgggagccgc tccagccctt gtgctcgcat tcggccatgc ccttggtgaa caggtcctcg 7921 gcccgccatg gctggtcgca gtacatgaag agcagggcga ccgcgacggg cacctcgaag 7981 ccgcggttct catcggtcca gctcatcccg ccgcgcagcg cctcctcggc atgccggagg 8041 gcggtctgcc gcggttcgcc gcgcaccagg gcgtcccacg cccgcaggcc caggatgtag 8101 cgctcctcca ggccgcggcc ggtcagcttg tcggcaaggc gcgccagtcg gcgcgagcgg 8161 gcggacgagt cgggttcgtc cgcgcggaac gcgctccaca cgaagtgatc ggcctgcata 8221 cgcagtttga tacgcggatt cggggcccgc cgcgcctcgt cggcggccac ggccgcggcc 8281 tcggtcagcc ggtcggtgtt ggccagcgcc tgggccagcc ggtagacgat ggaggcgcgg 8341 agctcggggt cgattccggg ctccgccagc gcctcctgga ggtggctgac cgtcgccgtg 8401 ggctcgatca ggaaggtcga gcaggcgagt tcgtgcagga gagctgcgcg gtcctccgcg 8461 ggcggcggtt cccgcagcgc ccgggtcagc acgcgacgcg cggcctccgg ggcaccggcg 8521 cggagatact cacgcgcggc ggcacgcagg accaggaccg cttcgggccg gccgtcgcag 8581 ggcacctcca gcaggtgccg ggcggcggcc gtggggccga accccgccgc ctgggcggcg 8641 tcggcggccg cgttgtgcat gccgacccgc agaccggagg ggatgtcgtg gtagatcgtc 8701 gtggcgatcg acgggtggac gaacgccagg ctgcggccgg gtccttcgcc gtccgcgagg 8761 atgcgggagg cgcgcagttt ccgggtcgcc tcggcggcgt cctcgttgcc gaccaccgcg 8821 atgccggcgg cgagttcggg ggagaaggac ccacccagta cggcggcggc ccacgcgaag 8881 cggacggtgc tcgtgccgag ccggtgaagg cgctcgatca gtcccgggcc cttgaccgcc 8941 gcggccaggt cgccgatcac gggcagctcg tcctgggtgc ccttcacccg gcgttcgcgg 9001 agcctgatgg ccagttcgac ggcctcgaag gggctgccgc cggtggccgt ccagcactcg 9061 ccgcagaaca cgtcctcggc ttcctcaccc acttcgttcc tgacgatccg cgccacaccg 9121 tccctgccca gcggagacag cgcgtgaggg cgctcctcgt ggcgttcgac gagggtgcgg 9181 aaggaggtcg cgtcgggcgg gaggtcgtcg ggtcggtagg cggcgaccat caggagcggg 9241 aggtccgcga cgcggggcgc gaaggaggcg agccagtcga gggattcggc gtcggcccag 9301 tgcaggtcgt ccaggagcag aacgacgggc gcgttcatca ccgtgaggcg cgtcatcacc 9361 cagtccaggc cgtcgcgcac gcccgtcggg tccggcatct gcgtgctgtc cgtcgcctcc 9421 aggccgagcg cggctccgac gatgccgtac caactgccca ggaattcccg gcgttccgtc 9481 tcgcccatcg tggccagggt gggctgcagg acctggcgga cgacgcggaa cgccaggccc 9541 tgctccttct cgccgcccgt gcccgagatc accgtgagcc cgagtgcggc ggcgcgggcg 9601 cgcgtcgccg cgatgagtgt ggtcttgccc agaccggccg cgccggtgaa ggcgagcaat 9661 ccgccgcgcg gcgcccggga cacgccgtcg acggcgtcac ggaggccgga caacgcggag 9721 tcgatcgcct tcagttcccg gtcgcgttcg agtagaggcc ggtgttcggt ggttggttgc 9781 cgcagcccat gggccatgtg gtccaccgct tcctgtcgtt gctccccgcg ggacgggggc 9841 gagcgtacgc cctcatggac accccttgga cggggtggaa caggaggtcg acagggaagg 9901 gtgaactttc ccgcagccgg cgttcaaatc ccggcgcttt gggtaaaatt tcgcgctccc 9961 gaacgggaac cgcgctgcgg gcgaccggcc gggcaggggc tcagggcacg gcggatgccg 10021 ccatcgtgtc cgcgtagcgt ggcacggtac gggaccagaa gtagcaaccg gggatccagc 10081 cgcccatgcc gtccacatag ccgacgccgc tggggctcaa ctccggcctg atctcatcgt 10141 agagctcctc gtactcgccg atcgtgctgt tgatgcgccg gatggccagc ctgaccgcct 10201 ccggcaggga gcactggtgc gcgcgctggt agtccagggc cagattgatc acgccgccgg 10261 cccgctgctc cttcacggcg gagaacaggt cggctatcca caccgccgcg tcgaccgaca 10321 gacgccccag gcgccggacg acgggatgcc ggagtacctc cggggccagc tcgtagggct 10381 gcgcggcctc gcacagcggg tggaacggct cgatgcccgc gatgagggag cgtatggacc 10441 ggcacagccc gctccccagc ggggcggagt ggctctgggc caccgcttcg tgcagcagac 10501 cgtgcacgta ctcacggctg ttccaggccc aacgcgcggc ctgagcgggt gtgcaccgct 10561 cctggacctg ccgttggaga tccgccaggg cggccccgag cgcggtgtcg ggcggttggc 10621 cgtcccgcag gatcctcacg ctctcggaca gcatgggcag cagccggccg ggccgctgca 10681 gacctatgtc ttccgcctgg tcgtcgaaga tgaactggta cgcaatctgg ttggccatga 10741 tctgcaggag accggaatcc acggccgggc tgttgtaggc cgcgagttcg gcggggcggg 10801 tataggagat catggccgcc accgccggat cgtcggtgag cccccaggtc ctcagccaat 10861 tctcgacgcc caccgccgct tcggaagcgt ggggattgct ctggaacggg aagggcatgt 10921 agaggttcgt gtcgatcagt tcccgcagat tgagggcggg aattccgcgc ggtgcggcga 10981 ccgcgatttc ctcatgcgtc gtggacaccg tcgccacctg ccgttccggg gtcgtggacg 11041 acgggggtca ccgtggcccg gggtgcgaga gaggtcgccc gaggcggtgt ggccggcggc 11101 cgttgtgctc gcggttcgca gaccatcacc agaccccgcg gccccaagga cgccgcgggg 11161 cgcagccgtg cgacgtgtcc gggcaggtgg cgcagccgcc agtggcgggc gatgaacgcg 11221 acggccaccg tggcctccgc catggcgaac gtctcgccga tgcagttccg ggtgccggcc 11281 gcgaacggga tcatcgcgcc gggcgggacc gcgacggccc gctccggacg ccagcggtcg 11341 gggaggaagc ggtcggggtc ggggaacgag gcggggtcat ggtggaggag atacgggctg 11401 tacaggacgg tggcgccccg cggaagacgt tgcccggcga gagccgtctc cttggtggtg 11461 acccgggtga agagccagcc cggcgggcgg tggcgaagcg tctcggtgac gacgcgccgc 11521 gtgtggacga gccgcggcaa ctcgtcgcgg ccgggcggcc gtccgtcggc gagcacggtg 11581 tcgacctcgg agtgcaggcg gcgttcgtcc tcgggatgcc gggccaggag atcgaaggcg 11641 gaggcgagac acagggcggt ggtctcggct ccggcgaata tcagcgtgag cgcctgactg 11701 cggacttcct gttcggtgat cgccgccgcc tcgccttcac tccgcgcggc cgacagcagt 11761 acgtccaaca agtcgtcccg gtcactcggg ggagtacctc gtaggcgctc ggcgatggcc 11821 gtgtcgacga tcgcgcgcag ccgctcggaa gcgtcccgga aacgccggtt cgcgggcgtg 11881 ggaacccgga acagcgcatc gaccggcacc accgtccgca ggaacaggcc gcgcacgatg 11941 gtgacgaggc aactgtgcac ctcggcggcc gtcgtggcgt ccagcgagtc ggagaacagg 12001 acgcggccga tcacccgcgc cgacagcgtc agcatggccg cgctgacgtc gacctcctgc 12061 cccgcccgcc actcgcggca caccgactcc acttcctcgc ccatcagttc cgtctgatcg 12121 gcgacacggg ccttgcggaa gccgggctgg agaagcctgc gctgccgccg atgggcctga 12181 tgagggcatg tgccgacgcc gtcacccaac agcgtccgca gcctgtcgta gagcggaccc 12241 cccttgtcga aggtgcgcgc gtccatgagt acctgatgga ccagctccgg gtggcacacc 12301 acccaggcgc gcagcggacc caggcgcacc tcgaccagat ccccgtgagc gggtaaggaa 12361 ttcagaaaat ccagcggccg ccgaaacaaa gcgataccgt gggctacggt ggggaatatg 12421 cctggcgcaa cccccaccct ccaggtgtgt ccggaatcag gcacgatacg actcatcgca 12481 aacccccagt ctcaatcgcc acgcggaagt cggtgaatgt tccaccgagt tgacgcttga 12541 gtcatgtcct gcccagttca accagctgcc gctttcgtga atcctttctt catgggggcg 12601 cacaggtgca cagcgaagca aagaaaccat tcggcagggt cgtccttgag aagcagaaat 12661 gcggccccac ccagaagaag gggcgggacc gcatccctgt tacccgtgtt cgctcacccg 12721 caccacacgc aacaccgggg acgacaggac gtccttctca cagaaccgcg ccgtcaccca 12781 cttctcaccg gagaacaacc gggtctggtc gctgaagtgg ggtgatcggg tgctcgacga 12841 ctgtgagtac gtcagcaacg tacgggccac cgggcagcgg ctgccgtccc agcccaccgc 12901 ctggatatgg ctggagccgg acgtcacctc cgtgtagccg ccccgcgcct ggtcccactc 12961 cggttcgatc ttgttccata cgcccatccc ctccgtgccg ccgtgcacgg ggatgcgctg 13021 accgttccgt acgacgacct ggtgctcgcc caggcgtgag tccagtgcga tgcccgccgc 13081 ccgcagctcg gccaccgcgt ccgcgagggc cgtggcgaaa ccgggagcgc cggtgttgag 13141 cgtgttcggg gtgcccaccg gatccgccgc cgagaacggc accttccacc gctgcgcggc 13201 cggcaccttc gcgctcagct tccgccagaa ccggtcgaag agcagggcgc cccggctacc 13261 ggtgtccatg gtgcgatccc aggcagccag caccgggcac gccccggaca catcaacggc 13321 cttgccgtca ctgcccgtcg ccgtgccgcc cggcagcgcc gcacacgcct tcgccgcgtc 13381 ggcggccacc aggtcgcccg ccggcacccg gttcgcgaac tgctgacgct ccaggtcccg 13441 cacggtcagc ccgccccgct cggccatcgc cgtgacgtcc tcgatcgcac cgcgggtgcg 13501 cagggagcgc tgggtgccga tgctgccgaa gacccgctcg taaccggtca gcggccggtc 13561 ggcgttggtg agccacgcgc tgtcgttgga gttctccaca tacggcgcgt ccttcagcgt 13621 cggcatgcgc gcgggcccga agatcccgcc ctgcagggcg tcggcgtcac tgccgagcgc 13681 gcattcgccg cgggagccgt cgaggacggc gatgcccgcc gcggggtagg tggtcctgcc 13741 caggccggtg aagcaccgcg ccgcgagatc gtcggtgatc cggggcagca cctgcgactg 13801 ggtgtacagc gagtgccccg aggagtccgc ggcgatggtg ttcacccagg gcaggccctg 13861 gttccgggtg agggacctga cgatgtcggc cgttccccgc gccttgccga aaccgagcga 13921 ggtgtcggcg aaccgcagat tggccgcgtt ggggtcgttg aaggcatacg ccgtcgacgc 13981 ggtccagggc agcgggagtt cgcccccgac cgaggcggcg acgggcccgt accgggtcca 14041 ccactgggtg cgcgtcaccg gtgcgccgtc cttgaccgcg acggtcaccg tccgcttcgt 14101 catccgctcc cgcccgccgt ccacgagata gacggtgggg tcggccggat ccagggtcag 14161 ctggtgcaga ctgaacggca caccggtcga caccgtgtgg ctccacgcca catgggagtt 14221 gtaaccgatg gcgatcgtcg gtgccccgag cagcgcggcg ccggcgacgt cgagctcgcc 14281 gggaatcgtc tgctgtgcct gccagaagcg gcgtccgccc tgccacgggt agtgcggatt 14341 gcccagcagc agaccgcggc cgttcgccgt ggtgtcgccg cggaaggcga ccgcgttgga 14401 ccccatcgcc gcgtcggcgg tccgcttgcg cacggcgcgg atcagggcct cggcgtccgg 14461 agcggtgtcc ttggccccgg gggcggtttc ggtgggcggc cgggcggatg tgatctcgtc 14521 cacggcgccg ccctggccgc cgagcacgga gagggcgtag aagcggatgg ccacatccag 14581 cgaggtgatg ggccggaccc acatggctcc ccggcacaca gggtcggtga tctgcttgtg 14641 gcgcagccac gcgttgtacc cggcggcgaa gcctcccatc agatccttga cctgacggct 14701 ggggccgcgc ggcgccggtt cggcgagcag cttctccacc gtgcgggtct ggcgtaggcc 14761 acggaagtac aggtcgccgg cgagattgct ggtcgccgag gacagcgcgg agtcgctcgc 14821 cgcgtccggt ccgaagaaac gcgaacgctc gcctcgtacg gtcacgaatc cgtcggccag 14881 ggtgcacacc tggtcggcgg cctgggccca accggtgccg aagccgaggg acttgtagtc 14941 cttggcgacg atgtgcggaa tgccgtactc ggtataacgg atcacggcgg acagaccacc 15001 gtgcgagggc cgttcctgat ggcccggccg ttcggccgcg ccggccggta acgcggccga 15061 ggcggtcagc agggcgacgg ccccgacgac cagtcgtctc aagcgggtgg tgcgcatctg 15121 tgcctcccaa cgtcagtgag ggaaggagcg gttgagcgtg ccacgggtcc gaccgcacct 15181 gtcgggtgct tgacccgcct cggtcacaca ccgaggatca tgagtcatga cgcagggaca 15241 gggcagcacg gttgacgggg tgctgcggcg cagcgcgcgg cggacaccgg cgcggaccgc 15301 cgtggagtac ggcgaccgca catggacgta cgaggaactc gaccaggccg tctcccgcgc 15361 ggcgagcgtc ctgctcgacc agggcctcgc acccggggac cgggtcggct cctacggcca 15421 caactcggac gcgtatctga tcggcttcct ggcctgcgcc cgcgcgggcc tcgtccatgt 15481 ccccgtcaac cagaacctga ccggcgacga cctcgcctac atcgtcggcc agtccggcgc 15541 cgccctggtc ctcaccgacc ccgacctggc cggccgactg tccgaggacg tccgtacgct 15601 gcccttgcgc gacgccgagg actccctcct ggcccgcctc gcgacggctc ccgagtacga 15661 cggccccgag ccgcgctccg aggacctcgt ccagctgctc tacacgtccg gtacgacggc 15721 cctgcccaag ggcgcgatga tgacgcaccg cgccctggtc cacgagtatc tgagcgccat 15781 cacggccctc gacctcagcg ccggcgaccg ccccgtgcac tccctgccgc tctaccactc 15841 ggcgcagatg catgtgttcc tgctgcccta cctcgcggtc ggcgccacga acatcatcct 15901 cgacgccccc gacggcgacc ggctcttcga cctcatcgag gccggccggg tggacagcct 15961 gttcgccccg cccaccgtgt ggatcggcct cgcgggccgc cccgacttcg ccgagcgcga 16021 cctcggcggg ctgcgcaagg cgtactacgg cgcgtcgatc atgcccgtcc cggtcctgga 16081 gcggctgcgt gaacggctcc cgaagctcgg cttctacaac tgcttcgggc agagcgagat 16141 cggcccgctg gccacggtgc tggccccgga cgaacacaag ggccggatgg actcctgcgg 16201 gcgcaccgtc ctcttcgtcg acgcccgtgt ggtcgacgaa cagggcgtgg aggtgcccga 16261 cggcacctcc ggcgagatcg tctaccggtc cccgcagctg tgcgagggct actgggacaa 16321 gcccgaggag accgccgagg ccttccggga cggctggttc cgctccggcg acctcgctgt 16381 gcgggacgca catggctact tcaccatcgt cgaccgggtg aaggacgtca tcaactccgg 16441 tggcgtactg gtcgcctccc ggcaggtcga ggacgcgctg tacacccatg agggcgtcgc 16501 cgaggtcgcc gtgatcggtc tgcccgacga gcggtggatc gaggccgtca cggcagtcgt 16561 cgtgccgcgc ggcgaggtgg gcgaggccga actgatcgag cacgcgcgcg agaagctggc 16621 ccacttcaag gcaccgaagc gggtcgtgtt cgtggacgag ctgccgcgca acgcgagcgg 16681 gaagattctc aagcgggagc tgcgggaccg attcgccgac aactaggtga tcagtgatcc 16741 gtggtcagcg ggggcgcaga tcctcgatgc gccggatctt gcccaccgac cgttccagcg 16801 actccggttc cacgatctcc accgcgaccg acaccccgat gccgtccttc accgccgccg 16861 cgatggcctg cgcggcggcg tcccgggtct cctgggacgc gtcgggacgg gcctccgccc 16921 gcacggtgag ggcgtcgaga cggccctccc gggtcagacg caactggaag tggggcgcca 16981 cacccgggat ccgcagcacg atctcctcga tctgcgtggg gaagagattg actccgcgca 17041 ggatgaccat gtcgtcactg cgcccggtga tcttctccat ccgccggaac acccgggcgg 17101 tccccggcag caaccgagtc aagtcccgtg tacggtaccg gatgacgggc atcgcctcct 17161 tggtgagcga ggtgaagacc agttcgccct cctcgccctc cggcagcacc tcaccggtga 17221 tcggatccac gatctcgggg aagaagtggt cctcccacac atggagcccg tccttggtct 17281 ccacacactc ctgcgcgaca ccgggcccga tcacctcgga cagtccgtat atgtcgacgg 17341 cgtcgatggc gaaccgctcc tcgatctcgc ggcgcatccg ctcggtccag ggttcggcac 17401 cgaagatgcc cacacgcagg gacgtaccgc gcggatcgac gccctggcgc tcgaactcgt 17461 cgagaagagt gagcatgtac gacggtgtca ccatgatgat ctcgggcctg aggtcctgga 17521 tcagctggac ctgccgggcc gtcatcccgc cggacgcggg gatgaccgtg catcccagtc 17581 tttcggcccc gtagtgtgcg ccgagcccac cggtgaacag cccatatccg taggccacat 17641 gaaccttgtc cccggggcgt ccgcccgccg cccggatgga tcgggccacc atgtcggacc 17701 acagggagag gtcggcatcg gtgtagccga cgaccgtggg gcgtccggtg gtgccgctgg 17761 aggcatggat acggcggata cggtcctgag gcacggcgaa catgccgtac gggtagttct 17821 ggcgcaggtc ggccttggtg gtgaacggga agcgggccag gtcgccgagt gagcggcagt 17881 cgtcggggtg cacgccggcc ttgtcgaagg actcccggta gaacggcacg ttgtcgtacg 17941 cgtgccgcag cgatctccgc aaccgctcca gctgcaactc ccgcagcgcc tccggggcga 18001 gccgttcccc cgagtccagc agttccgtcg catccgccat ggggaagctc tccctcgcca 18061 accgcgccat tccgggcgac cgatcattcg gtctgggtgt tcgggatcag taattcagca 18121 ggagaatgat caggcaaggg ggtggggcgc actttctggg gtcggggggc gcggacaatc 18181 tccgttgccc ctggtggccg actcggagca ggatcggcgc catgccgacc ttccgcgccg 18241 ccgacgggac cgagatcgcc taccacctgc gaggggaggg tgaaccgctg ctggtcctcc 18301 ccggcgggcc gatgcgggcc tcgggctatc tgggagacct cggcggactc gccgcgcacc 18361 ggcagctggt gctgctcgat ctgcgcggca ccggggactc ggccgagccg gaggacccgg 18421 ccacctaccg ctgcgaccac atggtggacg acgtcgagat attgcgggcc catatggggc 18481 gggcccatat ggatgtgttc ggacactcgg cgggcggcag cttggccatg ctgtacgcgg 18541 ctcggtatcc ggagcgggtg gcgcggctgg tgctggtgac cgcgacgccg tgggcgttgg 18601 ggatgctgcc cacggtcgag gaccggttgg cagccgcccg gttgcggaag ggcgagccgt 18661 ggttcgcgga ggcgttggcg gcgttcgagg cgtggctgac cggagcgggc gacttcgacc 18721 ccgtgttcgc gcccttcttc tacgggcgct gggacgacgc ggcaaagcag catgacgcgc 18781 gtggcgacgc cgagtacaac gacgaggcct ccggcatcta tggctccgcc ggcgccttcg 18841 atccaccgag gaccagcaca gaactctccc gcctgaccgc gccgactctc gtcctcgcgg 18901 gcgaactcga cggatccccc gatccggacc tcgcccgccg caccgccgac gtcttcccga 18961 acgccgagat cgccgtgcag cccggcgccg ggcaccatcc atggctggac ggcccggagt 19021 ggttcgtacg ccgtgttgcc gccttcctgg acgggaccgg ccttggaacg ggctgagtca 19081 ggccccgatg ctgtcggcct cccgcgtaca cgcccgctca gcggttgagg cgacgccgat 19141 acacgaagaa accggcggtc agcgccagcg cgccgacggc caggccggct ccgagggcca 19201 cctcgacgtc cgccggcccg gagctgccgc ccagcccgcc ccgcaccccc tgggtgggga 19261 cggccgaacg tgtgggaagc ggcgccagtg tcggcaacgg cgtgacgatc gagccgcggt 19321 gcggaaggtg tgcgcaggcg atgccgttgt tcctcccctg gtcccggccc gaacggtcgg 19381 ggtcgctgaa gccgcggtcg aactcggcct gcgcgtcctc ctggaaggtg aagtcgcggc 19441 agtccaggtc gccgcgggcg tatgccgcgg gggccgtcgg gccggcgagg gcgagaacgg 19501 tgatcgcggt cgtgcatatc gcgtggacgc gtcttttcac gggcgttgcc tttcggtccc 19561 gaggttccga ggtcccgagt tctcgacgac ctctattgcg accgtaggta cgccacccgt 19621 gcaccgtcgc ctgctgctac gccggacgag ctccgtcact cccgcgtcac ccggacggcc 19681 catcgacctc cccggtgccg cccttgccgt cccttcagtc ctcgccgctc agccgccctg 19741 cggaccgtac gccgtcatga agcggtccct gaagcggtcc atgccccagg tcggcgcgtt 19801 ctcggcgggc ttgaggccgt ccgtccagtg ccagtcggcg atccggtcga ggaccttcgg 19861 gtcgcgggcg acgacggtga cggggacgtc cttgctggta ctgcccgcgg tgaccgtggg 19921 gacgggctgg tggtcgccga ggaagacgag gaccgtgtcg tcggtgccgt agcgctggac 19981 ccactcggtg aggctgtgca gggagtactc gatggcgcgg cggtactcgg tgcggacgcg 20041 ctcggggtcc tgccagacct ccttggggtc ggtgccctcc ttcttgatct ggtggaagac 20101 cgagccgtcg cccaggtcgt tccagtcgac catgcgggcg atgggggacc agggattgtg 20161 gctggaggcc aggatgatct ccgccatgat cgggtctcgg ttcttcttgc cgtgctcaag 20221 gcgctggaac gcctccaggc tgaactggtc gggcaccggc gtccagctga agtacgggcc 20281 gtggtagccg aggtgctcgg agtcgtagat gtggtcgagc gcgaagaact tgccctccgg 20341 ccaggcccgc cgcacccccg gcacgacacc gaccgtccgc catgcgtcgg tcttcctgaa 20401 gtagctgccc agggtcgcgc gatcgctggt ggtgaggctc cggtaccgct gctggttctt 20461 gatccagaga ccggagagga acgtggagtg cgcgagccag ctgcccgccc ccgtcaccgg 20521 cgacttcagc catgcgctgc gcgactggaa cccggccgcc ttgagggtgt tcgtcccctc 20581 cttgagcgtc gcgtcgatct gcggcgccat cgcggggtcg tcgatcgcga cccggccgta 20641 gctctcgatg aacgtgaaca gcacgtcctt gccgcgcagc cccgtcagca gttggtccgg 20701 cggggtcttc gcgaaggcgt cgaccgctgc ctgcttctgg aagatccgtc cgtccttgag 20761 gcccgcctgc acctgctcga tacggttgtt gacgaagtcg gcgttgccct tggtggcgat 20821 cgggacaccg gcgatctgga tgcccagggt catacaggtg atccatgcgg tgccgaggac 20881 cagcgtcgta cgggtggcga tgtgacgatg gccgaccatc aggttcgtca cccgcaccat 20941 cgcgagcgtc atcaggacga gcaccgcgat gaacaggacc agcactccga ccaccgcgag 21001 cacctgcc //