LOCUS       NZ_BNBM01000011        21008 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence11, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000011
VERSION     NZ_BNBM01000011.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 315152)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 50427
            Orig. end                         :: 71435
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21008
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21008
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21008
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11008](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11008)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    689..705
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            704..2281
                     /locus_tag="IE325_RS26920"
                     /old_locus_tag="GCM10018780_54460"
     CDS             704..2281
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662859.1"
                     /locus_tag="IE325_RS26920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54460"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_190072660.1"
                     /sec_met_domain="DAO (E-value: 1.2e-08, bitscore: 29.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHEGTPGHRTYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLD
                     HTGGAAVSTRPFAGIDARLSRYSYLVSLLPKKIVRDLGLDFRIRTRDVSSYTPVERDGH
                     STGLLVGGGERRTREAFERLTGGEREYAAWQRFYGMTGEVARRVFPTLTEPLPSREELR
                     RRVDDEDAWRILFEEPIGVAIEDRFTDDLVRGVVLTDALIGTFADAHDTSLKQNRCFLY
                     HVIGGGTGDWDVPVGGMGALTDALATAARDAGAVIVTGHEAVRIDTDGRTAEVSFRTAD
                     GEGVAAARHVLVNASPQDLAALTGDTPPAPAEGAQLKVNMLLKRLPRLRDSSVDPREAF
                     SGTFHIAEGYDQLAAAHAQAAAGELPAAPPSEIYCHSLTDPTILAPDLVEQGYQTLTLF
                     GLHTPARLFAHDNDAVREELLKSTLAQLDAHLAEPIADCLATDADGRPCIEAKTPLDLE
                     RDLRLPGGNIFHRDLAWPYAQEGTGRWGVETPHANVLLCGAGAVRGGGVSGVPGHNAAM
                     AVLEAEQS"
     gene            complement(2286..4049)
                     /locus_tag="IE325_RS26925"
                     /old_locus_tag="GCM10018780_54470"
     CDS             complement(2286..4049)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379876.1"
                     /locus_tag="IE325_RS26925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54470"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_190072661.1"
                     /transl_table=11
                     /translation="MTDEVIPRLTRRQLGTLALGGALAIAPLPAGPAAATENARRTTLR
                     HGSPERAGLLPSHLRQLVTDAEAFLGPSPKYPWYAGAVLLAGRGGTVALHEPIGMAVRY
                     AAYDEKTDTGVEFPADQQLPMSQDTVFDLASVSKLFTSILAVQQIERGNLGLEAKVASY
                     LPDFGRAGKQDITIRQLLTHTSGFRPWIPLYAAPTYEEKLQLIWNEAPLNPPGTAYLYS
                     DLNLISLQLVLEEITGRSLDTLLHEDITGPLGMRRTRYNPPAAWKPRIAATEDARKPWS
                     GLDRGLVWGDVHDENAFSLGGVAGHAGVFSNAWDLAVLGRTLLNGGAYGRSRILEPESV
                     DLMFTDFNTNFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSLVLDPTTDSFLIV
                     LGNSVHPVRSWRTGSAPRVAAANNMARAVPVRPRHGRTAWFSGMATATTATLALPALDT
                     FGGDARLCCALWWDTEPQADGLTLEATTDGTTWQPLPFTTSRHGEPPQAHPTGTVTGWS
                     GRVWHRLTARLPEHRQLTLRWRYSTDRLYVGRGGYVDGLRVERADTVLFDEARPADAAR
                     ISASGWTASAD"
     misc_feature    complement(3966..3968)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4180..5289
                     /locus_tag="IE325_RS26930"
                     /old_locus_tag="GCM10018780_54480"
     CDS             4180..5289
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003890.1"
                     /locus_tag="IE325_RS26930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54480"
                     /product="nitronate monooxygenase family protein"
                     /protein_id="WP_190072662.1"
                     /transl_table=11
                     /translation="MQTELSNKLGIEHALFGFTPFPAVAAAISRAGGFGVLGAVRYTAP
                     DDLKRDLDWIEAHVDGRPYGLDVVMPAKKVEGVTEADVEAMIPEGHRQFVQDTLAKYGV
                     PELAEGEASGWRITGWMEQVARTQLDVAFDYPIKLLANALGSPPADVVERAHDRGVLVA
                     ALAGSARHARKHKEAGIDIVVAQGYEAGGHTGEIASMVLTPEVVEAVDPLPVLAAGGIG
                     SGQQVAAALSLGAQGVWLGSIWLTTTEADMHSPGLTAKLLAAGSGDTVRSRALTGKPAR
                     QLRTEWTDAWDDPNGPGTLPMPLQGLLVADAVSRIQKYEVAPLLGTPVGQIVGRMNSER
                     TVQAVVDDLTRGFEQAVDRINRIAGRSGQ"
     gene            5286..6863
                     /locus_tag="IE325_RS26935"
                     /old_locus_tag="GCM10018780_54490"
     CDS             5286..6863
                     /NRPS_PKS="Domain: AMP-binding (16-420). E-value: 3.5e-76.
                     Score: 248.3. Matches aSDomain:
                     nrpspksdomains_IE325_RS26935_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007503544.1"
                     /locus_tag="IE325_RS26935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54490"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_190072663.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-80, bitscore:
                     264.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTSAAHAVSTPPVGFWAQATADPDRTVLVAPDGEAWTAGRLHE
                     ATNRLVHGLRTAGLRRGDAFAVVLPNGVEFFTAYLAASQAGFYLVPVNHHFVGPEIAWI
                     VADSGAKVLIAHERYAEPARQAAEEAGLPADHRYAVGEVEGFRPYAELLEGQPESAPDD
                     RTLGWVMNYTSGTTGRPRGIRRPLSGKLPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYH
                     TAVLQFAGASLHIGHRLVLMDKWTPEEMLRVIDTHKCTHTHMVPTQFHRLLALPEGIRA
                     SYDVSSMRHAIHGAAPCPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTV
                     GKAWPISELAVFDDDGNRLPPGELGTVYLKMNTGGFAYHKDEAKTKKNRIGDFFTVGDL
                     GYLDEDGYLFLRDRKIDMIISGGVNIYPAEIESVLLAHPAVADAAAFGIPHDDWGEEVK
                     AVVEPAPGHEPGPDLAAAVLDHCAGQLAGYKRPKSVDFITEMPRDPNGKLYKRRLRDPY
                     WEGRTRPV"
     aSDomain        5334..6545
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS26935_AMP-binding.1"
                     /evalue="3.50E-76"
                     /label="IE325_RS26935_AMP-binding.1"
                     /locus_tag="IE325_RS26935"
                     /protein_end="420"
                     /protein_start="16"
                     /score="248.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FWAQATADPDRTVLVAPDGEAWTAGRLHEATNRLVHGLRTAGLRR
                     GDAFAVVLPNGVEFFTAYLAASQAGFYLVPVNHHFVGPEIAWIVADSGAKVLIAHERYA
                     EPARQAAEEAGLPADHRYAVGEVEGFRPYAELLEGQPESAPDDRTLGWVMNYTSGTTGR
                     PRGIRRPLSGKLPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYHTAVLQFAGASLHIGHR
                     LVLMDKWTPEEMLRVIDTHKCTHTHMVPTQFHRLLALPEGIRASYDVSSMRHAIHGAAP
                     CPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDG
                     NRLPPGELGTVYLKMNTGGFAYHKDEAKTKKNRIGDFFTVGDLGYLDEDGYLFLRDRKI
                     DMIIS"
     CDS_motif       5799..5834
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS26935_0001"
                     /evalue="5.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="IE325_RS26935"
                     /protein_end="183"
                     /protein_start="171"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YTSGTTGRPRGI"
     gene            complement(6888..9797)
                     /locus_tag="IE325_RS26940"
                     /old_locus_tag="GCM10018780_54500"
     CDS             complement(6888..9797)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982044.1"
                     /locus_tag="IE325_RS26940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54500"
                     /product="AAA family ATPase"
                     /protein_id="WP_190072664.1"
                     /transl_table=11
                     /translation="MAHGLRQPTTEHRPLLERDRELKAIDSALSGLRDAVDGVSRAPRG
                     GLLAFTGAAGLGKTTLIAATRARAAALGLTVISGTGGEKEQGLAFRVVRQVLQPTLATM
                     GETERREFLGSWYGIVGAALGLEATDSTQMPDPTGVRDGLDWVMTRLTVMNAPVVLLLD
                     DLHWADAESLDWLASFAPRVADLPLLMVAAYRPDDLPPDATSFRTLVERHEERPHALSP
                     LGRDGVARIVRNEVGEEAEDVFCGECWTATGGSPFEAVELAIRLRERRVKGTQDELPVI
                     GDLAAAVKGPGLIERLHRLGTSTVRFAWAAAVLGGSFSPELAAGIAVVGNEDAAEATRK
                     LRASRILADGEGPGRSLAFVHPSIATTIYHDIPSGLRVGMHNAAADAAQAAGFGPTAAA
                     RHLLEVPCDGRPEAVLVLRAAAREYLRAGAPEAARRVLTRALREPPPAEDRAALLHELA
                     CSTFLIEPTATVSHLQEALAEPGIDPELRASIVYRLAQALANTDRLTEAAAVAADEARR
                     APNPRIKLRMQADHFVWSAFRADEPDSSARSRRLARLADKLTGRGLEERYILGLRAWDA
                     LVRGEPRQTALRHAEEALRGGMSWTDENRGFEVPVAVALLFMYCDQPWRAEDLFTKGMA
                     ECEHKGWSGSHLAQGQTLSGYIRYRRGCLSEAEEFVRAGLHTAERVEGAVPAQWFAIGI
                     LIQILLARGRTEDARELADAHHYGDVVPNAVIFPDPRTVYAELLLAEERYAEAARLLSA
                     VGDWLESRNWRNPAWCPWQLDLASALARTAPEKAVRHAQDAVKRARDFGAASAIGQALS
                     VEAEVTGGPAALDLHAEAVEYLERSPASYELARALVGHGAALSRNGRVQEAAHRLYQGL
                     ESAVHCGAEGLAVRARQELSAAGLRPLPLRYAQTDTLTTRERQTAELTVQGQPEAVIAK
                     ELRLTEQGVRQLLSCVYRKIGTDAAGLAQALETFPCPRT"
     misc_feature    9790..9805
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.9"
                     /tool="antismash"
     misc_feature    complement(9876..9891)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.64"
                     /tool="antismash"
     gene            complement(10001..11008)
                     /locus_tag="IE325_RS26945"
                     /old_locus_tag="GCM10018780_54510"
     CDS             complement(10001..11008)
                     /EC_number="4.2.3.162"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048704.1"
                     /locus_tag="IE325_RS26945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54510"
                     /product="(-)-alpha-amorphene synthase"
                     /protein_id="WP_229912061.1"
                     /sec_met_domain="T1TS (E-value: 7.6e-60, bitscore: 197.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTHEEIAVAAPRGIPALNLRELIDTNLYMPFPFQSNPHASEAA
                     VGVENWLRTWGLTDDPAVAAMISYTRPAELAAYNSPAVDSGLLQIMANQIAYQFIFDDQ
                     AEDIGLQRPGRLLPMLSESVRILRDGQPPDTALGAALADLQRQVQERCTPAQAARWAWN
                     SREYVHGLLHEAVAQSHSAPLGSGLCRSIRSLIAGIEPFHPLCEAAQPYELAPEVLRHP
                     VVRRLGRLSVDAAVWIADLFSAVKEQRAGGVINLALDYQRAHQCSLPEAVRLAIRRINS
                     TIGEYEELYDEIRPELSPSGVGYVDGMGGWIPGCYFWSRTVPRYADTMAASAVP"
     gene            complement(10992..12476)
                     /locus_tag="IE325_RS26950"
                     /old_locus_tag="GCM10018780_54520"
     CDS             complement(10992..12476)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982041.1"
                     /locus_tag="IE325_RS26950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54520"
                     /product="cytochrome P450"
                     /protein_id="WP_190072666.1"
                     /sec_met_domain="p450 (E-value: 9.1e-72, bitscore: 236.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRIVPDSGHTWRVGVAPGIFPTVAHGIALFRRPLDFLNSLPAHG
                     DLVEVRLGPLRAWVVCHPELVHQVLMDARTFDKGGPLYDRLRTLLGDGVGTCPHQAHRR
                     QRRLLQPGFRKARVADQTELMGEEVESVCREWRAGQEVDVSAAMLTLSARVIGRVLFSD
                     SLDATTAAEVHSCLVTIVRGLFLRTVVPVDALFRVPTPANRRFRDASERLRAIVDTAIA
                     ERLRGTPPSDRDDLLDVLLSAARSEGEAAAITEQEVRSQALTLIFAGAETTALCLASAF
                     DLLARHPEDERRLHSEVDTVLADGRPPGRDELPRLVHTRRVVTETLRHRPPGWLFTRVT
                     TKETALAGQRLPRGATVLYSPYLLHHDPASFPDPDRFLPDRWRPERAVAVPPGAMIPFA
                     AGTRNCIGETFAMAEATVAVAFIARHWRLRHLPGHVARLRPAASLGPRGLVMVCEPRAQ
                     RPPATPPRATSLAPRATVTPVVHDPGTAGGDGVHDA"
     misc_feature    complement(12354..12356)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12700..15117)
                     /locus_tag="IE325_RS26955"
                     /old_locus_tag="GCM10018780_54530"
     CDS             complement(12700..15117)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313531.1"
                     /locus_tag="IE325_RS26955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54530"
                     /product="penicillin acylase family protein"
                     /protein_id="WP_190072667.1"
                     /transl_table=11
                     /translation="MRTTRLRRLVVGAVALLTASAALPAGAAERPGHQERPSHGGLSAV
                     IRYTEYGIPHIVAKDYKSLGFGTGWAQAADQVCTLADGFVTVRGERSRFFGPDAASDSA
                     LSSATSNLAGDLYFRGLRQTRTVEKLLAEPAPRGPSRQVKDLMGGFAAGYNAWLRHKQI
                     TDPVCRGAMWVRPITSLDVAIRFYALSVLGGQGGAVDEITSARPPTETAPGAKDTAPDA
                     EALIRAVRKRTADAAMGSNAVAFRGDTTANGRGLLLGNPHYPWQGGRRFWQAQQTIPGE
                     LDVAGAALLGAPTIAIGYNSHVAWSHTVSTGVPFSLHQLTLDPADPTVYLVDGGRERMT
                     KRTVTVAVKDGAPVTRTQWWTRYGPVAASVGGELPLPWTASTAYAFNDPNAANLRFADT
                     SLGFGKARGTADIVRSLTRNQGLPWVNTIAADSSGHSLYTQSQVLPRITDDLAARCFTG
                     LGRTTYPAAGIAVLDGSRGECALGSDADALQGGIFGPARMPTLKDAPYVENSNDSAWLT
                     NADRPLTGYERVFGSIGTQRSLRTRGAIEDVTAMAERGGLTVRDLERQQFANRVPAGDL
                     VAADAAKACAALPGGTATGSDGKAVDVSGACPVLAAWDRTMDTGSRGALLFDRFWRKLS
                     AKVPAAQRWKVPFSAADPVGTPNTLNTGAPGFATALADAVAELRAAGIALDSRLGEHQV
                     VVRNGQRIPVHGGTEGMGVWNKIEPEWDQARGGYTEVTSGSSHIQAVGWDGSRCPVART
                     LLTYSQSSSTRSPHFSDQTRLFSGEKWVTARFCEKDVLSSPVLRVVRVSEHG"
     misc_feature    complement(15049..15051)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15227..16726
                     /locus_tag="IE325_RS26960"
                     /old_locus_tag="GCM10018780_54540"
     CDS             15227..16726
                     /NRPS_PKS="Domain: AMP-binding (13-404). E-value: 3e-98.
                     Score: 321.0. Matches aSDomain:
                     nrpspksdomains_IE325_RS26960_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662872.1"
                     /locus_tag="IE325_RS26960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54540"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_190072668.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-101, bitscore:
                     334.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQGQGSTVDGVLRRSARRTPARTAVEYGDRTWTYEELDQAVSRA
                     ASVLLDQGLAPGDRVGSYGHNSDAYLIGFLACARAGLVHVPVNQNLTGDDLAYIVGQSG
                     AALVLTDPDLAGRLSEDVRTLPLRDAEDSLLARLATAPEYDGPEPRSEDLVQLLYTSGT
                     TALPKGAMMTHRALVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATN
                     IILDAPDGDRLFDLIEAGRVDSLFAPPTVWIGLAGRPDFAERDLGGLRKAYYGASIMPV
                     PVLERLRERLPKLGFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEQG
                     VEVPDGTSGEIVYRSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVK
                     DVINSGGVLVASRQVEDALYTHEGVAEVAVIGLPDERWIEAVTAVVVPRGEVGEAELIE
                     HAREKLAHFKAPKRVVFVDELPRNASGKILKRELRDRFADN"
     aSDomain        15266..16438
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS26960_AMP-binding.1"
                     /evalue="3.00E-98"
                     /label="IE325_RS26960_AMP-binding.1"
                     /locus_tag="IE325_RS26960"
                     /protein_end="404"
                     /protein_start="13"
                     /score="321.0"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="RRSARRTPARTAVEYGDRTWTYEELDQAVSRAASVLLDQGLAPGD
                     RVGSYGHNSDAYLIGFLACARAGLVHVPVNQNLTGDDLAYIVGQSGAALVLTDPDLAGR
                     LSEDVRTLPLRDAEDSLLARLATAPEYDGPEPRSEDLVQLLYTSGTTALPKGAMMTHRA
                     LVHEYLSAITALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATNIILDAPDGDRLFD
                     LIEAGRVDSLFAPPTVWIGLAGRPDFAERDLGGLRKAYYGASIMPVPVLERLRERLPKL
                     GFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEQGVEVPDGTSGEIVY
                     RSPQLCEGYWDKPEETAEAFRDGWFRSGDLAVRDAHGYFTIVDRVKDVINS"
     CDS_motif       15695..15748
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS26960_0001"
                     /evalue="2.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="IE325_RS26960"
                     /protein_end="174"
                     /protein_start="156"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LLYTSGTTALPKGAMMTH"
     CDS_motif       16256..16345
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS26960_0002"
                     /evalue="8.40E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="IE325_RS26960"
                     /protein_end="373"
                     /protein_start="343"
                     /score="24.6"
                     /tool="antismash"
                     /translation="PDGTSGEIVYRSPQLCEGYWDKPEETAEAF"
     gene            complement(16745..18040)
                     /gene="paaK"
                     /locus_tag="IE325_RS26965"
                     /old_locus_tag="GCM10018780_54550"
     CDS             complement(16745..18040)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (84-335). E-value: 1.1e-22.
                     Score: 72.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS26965_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007503538.1"
                     /locus_tag="IE325_RS26965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54550"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_190072669.1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-30, bitscore:
                     97.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADATELLDSGERLAPEALRELQLERLRRSLRHAYDNVPFYRESF
                     DKAGVHPDDCRSLGDLARFPFTTKADLRQNYPYGMFAVPQDRIRRIHASSGTTGRPTVV
                     GYTDADLSLWSDMVARSIRAAGGRPGDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPAS
                     GGMTARQVQLIQDLRPEIIMVTPSYMLTLLDEFERQGVDPRGTSLRVGIFGAEPWTERM
                     RREIEERFAIDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFFPEIVDPITGEVLPE
                     GEEGELVFTSLTKEAMPVIRYRTRDLTRLLPGTARVFRRMEKITGRSDDMVILRGVNLF
                     PTQIEEIVLRIPGVAPHFQLRLTREGRLDALTVRAEARPDASQETRDAAAQAIAAAVKD
                     GIGVSVAVEIVEPESLERSVGKIRRIEDLRPR"
     CDS_motif       complement(17006..17068)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS26965_0001"
                     /evalue="3.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="IE325_RS26965"
                     /protein_end="345"
                     /protein_start="324"
                     /score="13.3"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     aSDomain        complement(17036..17788)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS26965_AMP-binding.1"
                     /evalue="1.10E-22"
                     /label="IE325_RS26965_AMP-binding.1"
                     /locus_tag="IE325_RS26965"
                     /protein_end="335"
                     /protein_start="84"
                     /score="72.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QDRIRRIHASSGTTGRPTVVGYTDADLSLWSDMVARSIRAAGGRP
                     GDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDLRPEIIMVTPSY
                     MLTLLDEFERQGVDPRGTSLRVGIFGAEPWTERMRREIEERFAIDAVDIYGLSEVIGPG
                     VAQECVETKDGLHVWEDHFFPEIVDPITGEVLPEGEEGELVFTSLTKEAMPVIRYRTRD
                     LTRLLPGTARVFRRMEKITGRSDDMVILR"
     gene            18222..19076
                     /locus_tag="IE325_RS26970"
                     /old_locus_tag="GCM10018780_54560"
     CDS             18222..19076
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-265). E-value:
                     1.7e-29. Score: 95.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS26970_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433338.1"
                     /locus_tag="IE325_RS26970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54560"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_190072670.1"
                     /sec_met_domain="PF00561 (E-value: 6.7e-27, bitscore: 88.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-20, bitscore:
                     68.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTFRAADGTEIAYHLRGEGEPLLVLPGGPMRASGYLGDLGGLAA
                     HRQLVLLDLRGTGDSAEPEDPATYRCDHMVDDVEILRAHMGRAHMDVFGHSAGGSLAML
                     YAARYPERVARLVLVTATPWALGMLPTVEDRLAAARLRKGEPWFAEALAAFEAWLTGAG
                     DFDPVFAPFFYGRWDDAAKQHDARGDAEYNDEASGIYGSAGAFDPPRTSTELSRLTAPT
                     LVLAGELDGSPDPDLARRTADVFPNAEIAVQPGAGHHPWLDGPEWFVRRVAAFLDGTGL
                     GTG"
     aSDomain        18285..19016
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS26970_Abhydrolase_1.1"
                     /evalue="1.70E-29"
                     /label="IE325_RS26970_Abhydrolase_1.1"
                     /locus_tag="IE325_RS26970"
                     /protein_end="265"
                     /protein_start="21"
                     /score="95.1"
                     /tool="antismash"
                     /translation="PLLVLPGGPMRASGYLGDLGGLAAHRQLVLLDLRGTGDSAEPEDP
                     ATYRCDHMVDDVEILRAHMGRAHMDVFGHSAGGSLAMLYAARYPERVARLVLVTATPWA
                     LGMLPTVEDRLAAARLRKGEPWFAEALAAFEAWLTGAGDFDPVFAPFFYGRWDDAAKQH
                     DARGDAEYNDEASGIYGSAGAFDPPRTSTELSRLTAPTLVLAGELDGSPDPDLARRTAD
                     VFPNAEIAVQPGAGHHPWLDGP"
     CDS_motif       18498..18542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS26970_0001"
                     /evalue="1.40E-03"
                     /label="NRPS-te1"
                     /locus_tag="IE325_RS26970"
                     /protein_end="107"
                     /protein_start="92"
                     /score="11.2"
                     /tool="antismash"
                     /translation="FGHSAGGSLAMLYAA"
     gene            complement(19118..19540)
                     /locus_tag="IE325_RS26975"
                     /old_locus_tag="GCM10018780_54570"
     CDS             complement(19118..19540)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988819.1"
                     /locus_tag="IE325_RS26975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_54570"
                     /product="hypothetical protein"
                     /protein_id="WP_190072671.1"
                     /transl_table=11
                     /translation="MKRRVHAICTTAITVLALAGPTAPAAYARGDLDCRDFTFQEDAQA
                     EFDRGFSDPDRSGRDQGRNNGIACAHLPHRGSIVTPLPTLAPLPTRSAVPTQGVRGGLG
                     GSSGPADVEVALGAGLAVGALALTAGFFVYRRRLNR"
     misc_feature    19655..19670
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(20451..20469)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.99"
                     /tool="antismash"
ORIGIN
        1 tcggcccgca ccatcccgac acgctggtca cgcgctacga agtcgcctac gcgctcggcc
       61 agttgggccg ctgggcggaa gccctgcaga cctacggcga ggtcgccgag gcccgtgccc
      121 aggccctcgg ccccgatcac ccggacacgc tcgccgcccg ctacgaggtc ggcatcagcc
      181 tcggccgcct gggccgcagc gcggaggcgc tccggctcta ccgcgacctc gtcgacgacc
      241 ggacccgtgt ccacggcacc gcccaccccg agaccctgcg cgcccgccac ggcctcggcg
      301 tcaacctcgg ccgcctcggc cgctgggagg aggccctcgc cgagtcccgc gacgtgtgcg
      361 cgatccgtga gcgagtactg ggcgccgacc acccggacac cctggtcagc cgccgcgagg
      421 tcgccgtgag cctcggctgg ctgggccgct ggcccgacgc gctcaccgag taccgcacgg
      481 tggccgccgc ccgcgaacgc gtcctcggcg ccgaccaccc cgacaccctc gccagccgca
      541 acgacgaggc ccactgcctc cagcagctgg ggcgggaggc ggaggcggtc gagctgtacc
      601 ggagggtggc ggtgctgcgg cagcagcggg cgacgggcgg cccctgactc cggacgcgcg
      661 cgcatctctg gcccacctag atcatcacgt gttacgaaga accatgcctg cacacgaggg
      721 aaccccggga caccgtacgt acgacgccgt catcgtcggc ggagggcaca acggcctggt
      781 cgccgccgcc tacctggccc gggccgggcg gtccgtgctg gtgcttgagc ggctggacca
      841 cacgggcggt gccgccgtct ccacccggcc gttcgccggg atcgacgcac ggctgtcccg
      901 ttactcctac ctggtcagcc tgctgccgaa gaagatcgtc cgggacctcg gcctggattt
      961 ccggatccgc acccgcgatg tgtcctccta cacgcccgtg gaacgcgacg ggcactcaac
     1021 cggactactg gtgggcggcg gcgaacggcg tacccgggag gccttcgaac gactgaccgg
     1081 cggcgagcgc gagtacgcgg cctggcagcg cttctacggc atgacaggcg aggtcgcccg
     1141 ccgagtcttc ccgacgctca ccgaacccct gcccagccgc gaggaactgc gccgccgggt
     1201 ggacgacgag gacgcctggc gcatcctctt cgaggagccg atcggcgtcg cgatcgagga
     1261 ccgcttcacc gacgacctgg tgcggggcgt ggtcctcacg gacgccctga tcggcacctt
     1321 cgccgacgcc catgacacct cgctcaagca gaaccgttgc ttcctgtacc acgtgatcgg
     1381 cggtggcacc ggcgactggg acgtccccgt cggcggcatg ggcgccctca ccgacgccct
     1441 cgccacggcc gcgcgcgacg cgggggccgt gatcgtcacc gggcacgagg cggtacggat
     1501 cgacaccgac ggccgtacgg cggaggtcag cttccgtacg gcggacggcg agggcgtcgc
     1561 cgccgcccgg cacgtcctgg tgaacgcctc cccgcaggac ctggccgccc tcaccggcga
     1621 cacgcccccg gccccggccg agggcgccca gctcaaggtg aacatgctgc tcaagcgcct
     1681 gccccgattg cgcgacagct ccgtcgaccc gcgcgaggcg ttctccggca ccttccacat
     1741 cgccgagggc tatgaccagc tggccgccgc ccacgcccag gccgccgccg gcgaactccc
     1801 cgccgcgccc ccgtccgaga tctactgcca ctcgctgacc gacccgacca tcctcgcccc
     1861 cgacctggtc gaacagggct accagaccct caccctcttc ggcctgcaca ccccggcgag
     1921 gctcttcgcg cacgacaacg acgccgtacg cgaggaactc ctgaagtcga ccctcgccca
     1981 gctcgacgcc cacctcgccg agccgatcgc cgactgcctg gcgaccgacg ccgacggccg
     2041 gccttgcatc gaggcgaaga ccccgctcga cctggagcgc gacctgcgcc tgcccggtgg
     2101 caacatcttc caccgcgacc tcgcctggcc gtacgcccag gaaggcacgg gccgttgggg
     2161 cgtggagacc ccgcacgcga acgtgctgct gtgcggggcc ggcgcggtgc gcggaggagg
     2221 ggtgagcggg gtgcccggac acaacgcggc gatggcggtg ctggaggcgg aacagagctg
     2281 agccgtcagt ccgccgacgc cgtccagcca ctcgcgctga tccgcgccgc gtccgccggc
     2341 cgggcctcgt cgaagaggac ggtgtccgct ctctccacgc gcagcccgtc gacgtacccg
     2401 ccccggccca cgtacagccg gtcggtgctg tacctccagc ggagcgtcag ctgccgatgc
     2461 tcgggcagcc gtgccgtgag ccggtgccaa acgcggccgg accagccggt gaccgtgccg
     2521 gtcgggtggg cctgcggcgg ctcgccgtgg cggctcgtcg tgaacggcag cggttgccag
     2581 gtggtgccgt cggtcgtcgc ctccagggtg agcccgtccg cttggggttc ggtgtcccac
     2641 caaagtgcgc agcacagccg cgcgtcgcca ccgaacgtgt cgagcgcggg gagcgcgagg
     2701 gtcgcggtcg tggcggtcgc catgcccgag aaccatgccg tacgaccgtg tcgtgggcgt
     2761 acgggcacgg cgcgcgccat gttgttggcg gcggcgaccc ggggcgccga gccggtccgc
     2821 caactgcgca ccgggtggac cgagttgccc agcacgatca ggaacgagtc ggtcgtgggg
     2881 tcgaggacga gcgaggtgcc ggtgaagccg gtgtgtccgg cggtgcgcgg ggtcgccatc
     2941 gcgcccatgt accagtgctg gtagagctcg aaaccgaggc cgtgctcgtc gccggggaag
     3001 ttggtgttga agtcggtgaa catcaggtcg accgactccg gctcgaggat gcgggagcgg
     3061 ccgtaggcac cgccgttgag cagcgtcctg ccgaggaccg cgaggtccca cgcgttcgag
     3121 aacacgcccg cgtggcccgc gaccccgccg aggctgaagg cgttctcgtc gtgcacatcg
     3181 ccccagacga gaccccggtc aaggcctgac cagggtttgc gggcgtcctc ggtggcggcg
     3241 atcctcggct tccaggcggc gggcgggttg tagcgggtgc ggcgcatgcc gagcgggccg
     3301 gtgatgtcct cgtggaggag cgtgtccagg ctgcggccgg tgatctcctc caggaccagc
     3361 tggagggaga tcaggttcag gtccgagtag aggtacgcgg tccccggcgg gttcagcggc
     3421 gcctcgttcc agatgagctg gagcttttcc tcgtacgtcg gcgctgcgta cagcgggatc
     3481 caggggcgga accccgaggt gtgggtgagg agctgacgga tcgtgatgtc ctgcttgccc
     3541 gcgcgaccga agtcggggag gtacgaggcg accttcgcct ccagccccag gttgccccgc
     3601 tcgatctgct gtacggcgag gatcgaggtg aacagcttgg agaccgaggc cagatcgaag
     3661 acggtgtcct gagacatggg cagctgctgg tcggccggga actcgacgcc ggtgtcggtc
     3721 ttctcgtcgt acgccgcata gcgcaccgcc atgccgatcg gctcgtgcag cgccacggtg
     3781 ccgccacggc cggcgagcag cacggcgccc gcgtaccagg ggtacttggg ggaggggccc
     3841 aggaacgcct cagcgtcggt gacgagttgg cggaggtgag aggggaggag gcctgcacgt
     3901 tcgggggagc cgtggcgcaa ggtggtacgg cgggcgttct cggtggcggc cgccggtcct
     3961 gcgggtaagg gggcgatggc cagggcgccg cccagggcca gggttcccag ctgacggcgg
     4021 gtaagtctcg ggatcacctc atcggtcatc gtgaaacctt gctgtcgggg ggtggccgtg
     4081 tcaatgaggc gtgcgtgccc cgtcccaggg gcggcagaaa actgacggag catcagaaag
     4141 ccccttccct cctccggagg actccggcat cctgcgccca tgcagacgga gctgagcaac
     4201 aaactgggaa tcgagcacgc ccttttcggc ttcacgccgt tccccgccgt cgccgcggcc
     4261 atcagccggg ccggcggttt cggagtgctc ggcgcggtcc gctacaccgc ccccgacgac
     4321 ctcaaacgcg acctcgactg gatcgaggca catgtcgacg ggcggcccta cggcctggac
     4381 gtcgtcatgc cggcgaagaa ggtggagggc gtcaccgagg ccgacgtgga ggcgatgatc
     4441 cctgaggggc accggcagtt cgtccaggac actctcgcca agtacggcgt gcccgaactc
     4501 gccgaggggg aggcctccgg ctggcgtatc accggctgga tggagcaggt cgcccgcacc
     4561 cagctcgacg tcgccttcga ctaccccatc aagctgctcg ccaacgccct cggctcaccg
     4621 cccgctgacg tcgtggagcg cgcccatgac cgcggtgtcc tcgtcgccgc gctcgcgggc
     4681 agcgcccggc atgcccgcaa gcacaaggag gcgggcatcg acatcgtcgt cgcccaggga
     4741 tacgaggccg gcggccacac cggtgagatc gcctccatgg tgctcacccc cgaagtggtg
     4801 gaagcggtcg acccgctgcc cgtgctcgcg gccgggggca tcggcagcgg ccaacaggtg
     4861 gctgccgcgc tcagtctcgg cgcccagggt gtgtggttgg gctccatatg gctgaccacc
     4921 acagaagccg atatgcactc acccggcctg acggcgaagc tgctcgccgc cggctccggc
     4981 gacaccgtcc gctcccgggc cctgaccggg aagcccgcac gccagctgcg caccgagtgg
     5041 accgacgcct gggacgaccc gaacggaccc ggcaccctcc ccatgcccct ccagggactc
     5101 ctcgtggccg acgccgtctc ccggatccag aagtacgagg tcgcaccgct gctcggcaca
     5161 cccgtcggcc agatcgtcgg ccgtatgaac agcgaacgca ccgtccaggc cgtcgtcgac
     5221 gacctcaccc ggggcttcga gcaggccgtc gaccgcatca accgcatcgc cggaaggagc
     5281 ggccagtgac cagcacctcc gccgcacacg ccgtcagcac cccgcccgtg ggcttctggg
     5341 cccaggccac cgccgacccc gaccgcacgg tcctcgtcgc gcccgacgga gaggcctgga
     5401 ccgcaggacg cctgcacgag gccaccaacc gcctagtgca cggcctgcgc acggcgggcc
     5461 tgcggcgcgg cgacgccttc gcggtcgtcc tccccaacgg cgtcgagttc ttcacggcct
     5521 acctggccgc gtcccaggcc ggcttctacc tggtccccgt caaccatcac ttcgtaggcc
     5581 ccgagatcgc ctggatcgtc gccgactccg gcgccaaggt gctcatcgcc catgagcgct
     5641 acgccgagcc cgcccgccag gccgccgagg aagcgggcct tccggccgac caccggtacg
     5701 cggtcggcga ggtcgagggc ttccggccgt acgccgaact cctcgaagga caaccggagt
     5761 cggcgcccga cgaccgcacc ctcggctggg tcatgaacta cacctccggc accacagggc
     5821 gcccccgcgg catccgccgc ccgctgtccg gcaaactccc cgaagaggcc tacctgggcg
     5881 gcttcctcgg catcttcggc atcaaaccgt tcgacgacaa tgtgcacctc gtctgctcac
     5941 cgctgtacca cacagcagtg ctccagttcg cgggcgcatc cctccacata gggcaccgcc
     6001 tggtgctgat ggacaagtgg acgcccgaag agatgctccg tgtcatcgac acacacaagt
     6061 gcacccacac ccatatggtc ccgacccagt tccaccgtct gctcgccctc ccggagggga
     6121 tacgggccag ctacgacgtc tcctccatgc ggcacgccat ccatggcgcc gccccctgcc
     6181 cggaccatgt gaagcgggcc atgctcgact ggtggggccc ctgtgtggag gagtactacg
     6241 ccgcgagcga gggcggtggt gccttcgcga ccgccgagga ctggctgaag aagcccggca
     6301 cggtgggcaa ggcctggccg atcagcgaac tcgccgtctt cgacgacgac ggcaaccggc
     6361 tcccgccggg tgaactcggc accgtctacc tcaagatgaa caccggcggc ttcgcctacc
     6421 acaaggacga ggcgaagacg aagaagaacc gcatcgggga cttcttcacg gtcggcgacc
     6481 tcggctatct cgacgaggac ggctatctct tcctccgcga ccgcaagatc gacatgatca
     6541 tctccggtgg ggtcaacatc tacccggccg agatcgagtc cgtcctgctc gcccacccgg
     6601 ccgtcgccga cgccgccgca ttcggcatcc cccatgacga ctggggcgag gaggtcaagg
     6661 ccgtcgtcga gccggccccc ggacatgaac ccggccccga cctcgccgcc gccgtactcg
     6721 accactgcgc gggacagctc gccggctaca agcggcccaa gagcgtcgac ttcatcaccg
     6781 agatgccgcg cgatcccaac ggcaagctgt acaagcggcg gctgcgcgat ccgtactggg
     6841 aggggcgcac ccggccggtg tgatcgtggg cgcggggcgt cagcgggtca tgtccgaggg
     6901 cacgggaagg tctccagagc ctgggcgagg cccgccgcgt cggtgccgat cttgcgatag
     6961 acgcaggaca gcagctgccg cacaccctgc tcggtgagac gcagctcctt cgcgatcacc
     7021 gcctccggct ggccctgaac ggtcagttcg gccgtctggc gttcccgagt ggtgagggtg
     7081 tccgtctgtg cgtagcgcag cggcagcggt cgcagcccgg ccgccgagag ttcctgcctg
     7141 gcccggacgg ccaggccctc ggcaccacag tgaaccgcgc tctccagccc ctggtagagc
     7201 cggtgggcgg cctcctgcac ccgtccgttg cgcgacagcg cggcgccgtg ccccacgagc
     7261 gcacgcgcca attcgtacga cgcgggggag cgctccaggt actcgacggc ctcggcgtgc
     7321 agatcgagcg cggccggacc gccggtcacc tcggcctcga cggagagcgc ctgcccgatc
     7381 gcggaggccg caccgaagtc ccgcgcccgc ttgacggcgt cctgagcgtg ccggaccgcc
     7441 ttctcggggg cggtgcgggc gagagcggag gccaggtcca gctgccacgg acaccacgcc
     7501 gggttgcgcc agttccgtga ctccagccag tccccgacgg cggacaacag ccgtgccgcc
     7561 tccgcgtacc gctcctcggc caggagcagt tcggcgtaca ccgtgcgggg atcggggaag
     7621 atcacggcgt tcgggaccac atcgccgtag tgatgggcgt cggcgagctc acgcgcgtcc
     7681 tcggtccgcc cgcgggccag caggatctgg atgaggatgc cgatggcgaa ccactgggcg
     7741 ggtaccgcgc cttcgacgcg ctcggcggtg tgcagcccgg cccgtacgaa ctcctccgcc
     7801 tcggagagac agccgcgacg gtagcggatg tagccggaga gggtctgccc ctgcgccaga
     7861 tgggagccgc tccagccctt gtgctcgcat tcggccatgc ccttggtgaa caggtcctcg
     7921 gcccgccatg gctggtcgca gtacatgaag agcagggcga ccgcgacggg cacctcgaag
     7981 ccgcggttct catcggtcca gctcatcccg ccgcgcagcg cctcctcggc atgccggagg
     8041 gcggtctgcc gcggttcgcc gcgcaccagg gcgtcccacg cccgcaggcc caggatgtag
     8101 cgctcctcca ggccgcggcc ggtcagcttg tcggcaaggc gcgccagtcg gcgcgagcgg
     8161 gcggacgagt cgggttcgtc cgcgcggaac gcgctccaca cgaagtgatc ggcctgcata
     8221 cgcagtttga tacgcggatt cggggcccgc cgcgcctcgt cggcggccac ggccgcggcc
     8281 tcggtcagcc ggtcggtgtt ggccagcgcc tgggccagcc ggtagacgat ggaggcgcgg
     8341 agctcggggt cgattccggg ctccgccagc gcctcctgga ggtggctgac cgtcgccgtg
     8401 ggctcgatca ggaaggtcga gcaggcgagt tcgtgcagga gagctgcgcg gtcctccgcg
     8461 ggcggcggtt cccgcagcgc ccgggtcagc acgcgacgcg cggcctccgg ggcaccggcg
     8521 cggagatact cacgcgcggc ggcacgcagg accaggaccg cttcgggccg gccgtcgcag
     8581 ggcacctcca gcaggtgccg ggcggcggcc gtggggccga accccgccgc ctgggcggcg
     8641 tcggcggccg cgttgtgcat gccgacccgc agaccggagg ggatgtcgtg gtagatcgtc
     8701 gtggcgatcg acgggtggac gaacgccagg ctgcggccgg gtccttcgcc gtccgcgagg
     8761 atgcgggagg cgcgcagttt ccgggtcgcc tcggcggcgt cctcgttgcc gaccaccgcg
     8821 atgccggcgg cgagttcggg ggagaaggac ccacccagta cggcggcggc ccacgcgaag
     8881 cggacggtgc tcgtgccgag ccggtgaagg cgctcgatca gtcccgggcc cttgaccgcc
     8941 gcggccaggt cgccgatcac gggcagctcg tcctgggtgc ccttcacccg gcgttcgcgg
     9001 agcctgatgg ccagttcgac ggcctcgaag gggctgccgc cggtggccgt ccagcactcg
     9061 ccgcagaaca cgtcctcggc ttcctcaccc acttcgttcc tgacgatccg cgccacaccg
     9121 tccctgccca gcggagacag cgcgtgaggg cgctcctcgt ggcgttcgac gagggtgcgg
     9181 aaggaggtcg cgtcgggcgg gaggtcgtcg ggtcggtagg cggcgaccat caggagcggg
     9241 aggtccgcga cgcggggcgc gaaggaggcg agccagtcga gggattcggc gtcggcccag
     9301 tgcaggtcgt ccaggagcag aacgacgggc gcgttcatca ccgtgaggcg cgtcatcacc
     9361 cagtccaggc cgtcgcgcac gcccgtcggg tccggcatct gcgtgctgtc cgtcgcctcc
     9421 aggccgagcg cggctccgac gatgccgtac caactgccca ggaattcccg gcgttccgtc
     9481 tcgcccatcg tggccagggt gggctgcagg acctggcgga cgacgcggaa cgccaggccc
     9541 tgctccttct cgccgcccgt gcccgagatc accgtgagcc cgagtgcggc ggcgcgggcg
     9601 cgcgtcgccg cgatgagtgt ggtcttgccc agaccggccg cgccggtgaa ggcgagcaat
     9661 ccgccgcgcg gcgcccggga cacgccgtcg acggcgtcac ggaggccgga caacgcggag
     9721 tcgatcgcct tcagttcccg gtcgcgttcg agtagaggcc ggtgttcggt ggttggttgc
     9781 cgcagcccat gggccatgtg gtccaccgct tcctgtcgtt gctccccgcg ggacgggggc
     9841 gagcgtacgc cctcatggac accccttgga cggggtggaa caggaggtcg acagggaagg
     9901 gtgaactttc ccgcagccgg cgttcaaatc ccggcgcttt gggtaaaatt tcgcgctccc
     9961 gaacgggaac cgcgctgcgg gcgaccggcc gggcaggggc tcagggcacg gcggatgccg
    10021 ccatcgtgtc cgcgtagcgt ggcacggtac gggaccagaa gtagcaaccg gggatccagc
    10081 cgcccatgcc gtccacatag ccgacgccgc tggggctcaa ctccggcctg atctcatcgt
    10141 agagctcctc gtactcgccg atcgtgctgt tgatgcgccg gatggccagc ctgaccgcct
    10201 ccggcaggga gcactggtgc gcgcgctggt agtccagggc cagattgatc acgccgccgg
    10261 cccgctgctc cttcacggcg gagaacaggt cggctatcca caccgccgcg tcgaccgaca
    10321 gacgccccag gcgccggacg acgggatgcc ggagtacctc cggggccagc tcgtagggct
    10381 gcgcggcctc gcacagcggg tggaacggct cgatgcccgc gatgagggag cgtatggacc
    10441 ggcacagccc gctccccagc ggggcggagt ggctctgggc caccgcttcg tgcagcagac
    10501 cgtgcacgta ctcacggctg ttccaggccc aacgcgcggc ctgagcgggt gtgcaccgct
    10561 cctggacctg ccgttggaga tccgccaggg cggccccgag cgcggtgtcg ggcggttggc
    10621 cgtcccgcag gatcctcacg ctctcggaca gcatgggcag cagccggccg ggccgctgca
    10681 gacctatgtc ttccgcctgg tcgtcgaaga tgaactggta cgcaatctgg ttggccatga
    10741 tctgcaggag accggaatcc acggccgggc tgttgtaggc cgcgagttcg gcggggcggg
    10801 tataggagat catggccgcc accgccggat cgtcggtgag cccccaggtc ctcagccaat
    10861 tctcgacgcc caccgccgct tcggaagcgt ggggattgct ctggaacggg aagggcatgt
    10921 agaggttcgt gtcgatcagt tcccgcagat tgagggcggg aattccgcgc ggtgcggcga
    10981 ccgcgatttc ctcatgcgtc gtggacaccg tcgccacctg ccgttccggg gtcgtggacg
    11041 acgggggtca ccgtggcccg gggtgcgaga gaggtcgccc gaggcggtgt ggccggcggc
    11101 cgttgtgctc gcggttcgca gaccatcacc agaccccgcg gccccaagga cgccgcgggg
    11161 cgcagccgtg cgacgtgtcc gggcaggtgg cgcagccgcc agtggcgggc gatgaacgcg
    11221 acggccaccg tggcctccgc catggcgaac gtctcgccga tgcagttccg ggtgccggcc
    11281 gcgaacggga tcatcgcgcc gggcgggacc gcgacggccc gctccggacg ccagcggtcg
    11341 gggaggaagc ggtcggggtc ggggaacgag gcggggtcat ggtggaggag atacgggctg
    11401 tacaggacgg tggcgccccg cggaagacgt tgcccggcga gagccgtctc cttggtggtg
    11461 acccgggtga agagccagcc cggcgggcgg tggcgaagcg tctcggtgac gacgcgccgc
    11521 gtgtggacga gccgcggcaa ctcgtcgcgg ccgggcggcc gtccgtcggc gagcacggtg
    11581 tcgacctcgg agtgcaggcg gcgttcgtcc tcgggatgcc gggccaggag atcgaaggcg
    11641 gaggcgagac acagggcggt ggtctcggct ccggcgaata tcagcgtgag cgcctgactg
    11701 cggacttcct gttcggtgat cgccgccgcc tcgccttcac tccgcgcggc cgacagcagt
    11761 acgtccaaca agtcgtcccg gtcactcggg ggagtacctc gtaggcgctc ggcgatggcc
    11821 gtgtcgacga tcgcgcgcag ccgctcggaa gcgtcccgga aacgccggtt cgcgggcgtg
    11881 ggaacccgga acagcgcatc gaccggcacc accgtccgca ggaacaggcc gcgcacgatg
    11941 gtgacgaggc aactgtgcac ctcggcggcc gtcgtggcgt ccagcgagtc ggagaacagg
    12001 acgcggccga tcacccgcgc cgacagcgtc agcatggccg cgctgacgtc gacctcctgc
    12061 cccgcccgcc actcgcggca caccgactcc acttcctcgc ccatcagttc cgtctgatcg
    12121 gcgacacggg ccttgcggaa gccgggctgg agaagcctgc gctgccgccg atgggcctga
    12181 tgagggcatg tgccgacgcc gtcacccaac agcgtccgca gcctgtcgta gagcggaccc
    12241 cccttgtcga aggtgcgcgc gtccatgagt acctgatgga ccagctccgg gtggcacacc
    12301 acccaggcgc gcagcggacc caggcgcacc tcgaccagat ccccgtgagc gggtaaggaa
    12361 ttcagaaaat ccagcggccg ccgaaacaaa gcgataccgt gggctacggt ggggaatatg
    12421 cctggcgcaa cccccaccct ccaggtgtgt ccggaatcag gcacgatacg actcatcgca
    12481 aacccccagt ctcaatcgcc acgcggaagt cggtgaatgt tccaccgagt tgacgcttga
    12541 gtcatgtcct gcccagttca accagctgcc gctttcgtga atcctttctt catgggggcg
    12601 cacaggtgca cagcgaagca aagaaaccat tcggcagggt cgtccttgag aagcagaaat
    12661 gcggccccac ccagaagaag gggcgggacc gcatccctgt tacccgtgtt cgctcacccg
    12721 caccacacgc aacaccgggg acgacaggac gtccttctca cagaaccgcg ccgtcaccca
    12781 cttctcaccg gagaacaacc gggtctggtc gctgaagtgg ggtgatcggg tgctcgacga
    12841 ctgtgagtac gtcagcaacg tacgggccac cgggcagcgg ctgccgtccc agcccaccgc
    12901 ctggatatgg ctggagccgg acgtcacctc cgtgtagccg ccccgcgcct ggtcccactc
    12961 cggttcgatc ttgttccata cgcccatccc ctccgtgccg ccgtgcacgg ggatgcgctg
    13021 accgttccgt acgacgacct ggtgctcgcc caggcgtgag tccagtgcga tgcccgccgc
    13081 ccgcagctcg gccaccgcgt ccgcgagggc cgtggcgaaa ccgggagcgc cggtgttgag
    13141 cgtgttcggg gtgcccaccg gatccgccgc cgagaacggc accttccacc gctgcgcggc
    13201 cggcaccttc gcgctcagct tccgccagaa ccggtcgaag agcagggcgc cccggctacc
    13261 ggtgtccatg gtgcgatccc aggcagccag caccgggcac gccccggaca catcaacggc
    13321 cttgccgtca ctgcccgtcg ccgtgccgcc cggcagcgcc gcacacgcct tcgccgcgtc
    13381 ggcggccacc aggtcgcccg ccggcacccg gttcgcgaac tgctgacgct ccaggtcccg
    13441 cacggtcagc ccgccccgct cggccatcgc cgtgacgtcc tcgatcgcac cgcgggtgcg
    13501 cagggagcgc tgggtgccga tgctgccgaa gacccgctcg taaccggtca gcggccggtc
    13561 ggcgttggtg agccacgcgc tgtcgttgga gttctccaca tacggcgcgt ccttcagcgt
    13621 cggcatgcgc gcgggcccga agatcccgcc ctgcagggcg tcggcgtcac tgccgagcgc
    13681 gcattcgccg cgggagccgt cgaggacggc gatgcccgcc gcggggtagg tggtcctgcc
    13741 caggccggtg aagcaccgcg ccgcgagatc gtcggtgatc cggggcagca cctgcgactg
    13801 ggtgtacagc gagtgccccg aggagtccgc ggcgatggtg ttcacccagg gcaggccctg
    13861 gttccgggtg agggacctga cgatgtcggc cgttccccgc gccttgccga aaccgagcga
    13921 ggtgtcggcg aaccgcagat tggccgcgtt ggggtcgttg aaggcatacg ccgtcgacgc
    13981 ggtccagggc agcgggagtt cgcccccgac cgaggcggcg acgggcccgt accgggtcca
    14041 ccactgggtg cgcgtcaccg gtgcgccgtc cttgaccgcg acggtcaccg tccgcttcgt
    14101 catccgctcc cgcccgccgt ccacgagata gacggtgggg tcggccggat ccagggtcag
    14161 ctggtgcaga ctgaacggca caccggtcga caccgtgtgg ctccacgcca catgggagtt
    14221 gtaaccgatg gcgatcgtcg gtgccccgag cagcgcggcg ccggcgacgt cgagctcgcc
    14281 gggaatcgtc tgctgtgcct gccagaagcg gcgtccgccc tgccacgggt agtgcggatt
    14341 gcccagcagc agaccgcggc cgttcgccgt ggtgtcgccg cggaaggcga ccgcgttgga
    14401 ccccatcgcc gcgtcggcgg tccgcttgcg cacggcgcgg atcagggcct cggcgtccgg
    14461 agcggtgtcc ttggccccgg gggcggtttc ggtgggcggc cgggcggatg tgatctcgtc
    14521 cacggcgccg ccctggccgc cgagcacgga gagggcgtag aagcggatgg ccacatccag
    14581 cgaggtgatg ggccggaccc acatggctcc ccggcacaca gggtcggtga tctgcttgtg
    14641 gcgcagccac gcgttgtacc cggcggcgaa gcctcccatc agatccttga cctgacggct
    14701 ggggccgcgc ggcgccggtt cggcgagcag cttctccacc gtgcgggtct ggcgtaggcc
    14761 acggaagtac aggtcgccgg cgagattgct ggtcgccgag gacagcgcgg agtcgctcgc
    14821 cgcgtccggt ccgaagaaac gcgaacgctc gcctcgtacg gtcacgaatc cgtcggccag
    14881 ggtgcacacc tggtcggcgg cctgggccca accggtgccg aagccgaggg acttgtagtc
    14941 cttggcgacg atgtgcggaa tgccgtactc ggtataacgg atcacggcgg acagaccacc
    15001 gtgcgagggc cgttcctgat ggcccggccg ttcggccgcg ccggccggta acgcggccga
    15061 ggcggtcagc agggcgacgg ccccgacgac cagtcgtctc aagcgggtgg tgcgcatctg
    15121 tgcctcccaa cgtcagtgag ggaaggagcg gttgagcgtg ccacgggtcc gaccgcacct
    15181 gtcgggtgct tgacccgcct cggtcacaca ccgaggatca tgagtcatga cgcagggaca
    15241 gggcagcacg gttgacgggg tgctgcggcg cagcgcgcgg cggacaccgg cgcggaccgc
    15301 cgtggagtac ggcgaccgca catggacgta cgaggaactc gaccaggccg tctcccgcgc
    15361 ggcgagcgtc ctgctcgacc agggcctcgc acccggggac cgggtcggct cctacggcca
    15421 caactcggac gcgtatctga tcggcttcct ggcctgcgcc cgcgcgggcc tcgtccatgt
    15481 ccccgtcaac cagaacctga ccggcgacga cctcgcctac atcgtcggcc agtccggcgc
    15541 cgccctggtc ctcaccgacc ccgacctggc cggccgactg tccgaggacg tccgtacgct
    15601 gcccttgcgc gacgccgagg actccctcct ggcccgcctc gcgacggctc ccgagtacga
    15661 cggccccgag ccgcgctccg aggacctcgt ccagctgctc tacacgtccg gtacgacggc
    15721 cctgcccaag ggcgcgatga tgacgcaccg cgccctggtc cacgagtatc tgagcgccat
    15781 cacggccctc gacctcagcg ccggcgaccg ccccgtgcac tccctgccgc tctaccactc
    15841 ggcgcagatg catgtgttcc tgctgcccta cctcgcggtc ggcgccacga acatcatcct
    15901 cgacgccccc gacggcgacc ggctcttcga cctcatcgag gccggccggg tggacagcct
    15961 gttcgccccg cccaccgtgt ggatcggcct cgcgggccgc cccgacttcg ccgagcgcga
    16021 cctcggcggg ctgcgcaagg cgtactacgg cgcgtcgatc atgcccgtcc cggtcctgga
    16081 gcggctgcgt gaacggctcc cgaagctcgg cttctacaac tgcttcgggc agagcgagat
    16141 cggcccgctg gccacggtgc tggccccgga cgaacacaag ggccggatgg actcctgcgg
    16201 gcgcaccgtc ctcttcgtcg acgcccgtgt ggtcgacgaa cagggcgtgg aggtgcccga
    16261 cggcacctcc ggcgagatcg tctaccggtc cccgcagctg tgcgagggct actgggacaa
    16321 gcccgaggag accgccgagg ccttccggga cggctggttc cgctccggcg acctcgctgt
    16381 gcgggacgca catggctact tcaccatcgt cgaccgggtg aaggacgtca tcaactccgg
    16441 tggcgtactg gtcgcctccc ggcaggtcga ggacgcgctg tacacccatg agggcgtcgc
    16501 cgaggtcgcc gtgatcggtc tgcccgacga gcggtggatc gaggccgtca cggcagtcgt
    16561 cgtgccgcgc ggcgaggtgg gcgaggccga actgatcgag cacgcgcgcg agaagctggc
    16621 ccacttcaag gcaccgaagc gggtcgtgtt cgtggacgag ctgccgcgca acgcgagcgg
    16681 gaagattctc aagcgggagc tgcgggaccg attcgccgac aactaggtga tcagtgatcc
    16741 gtggtcagcg ggggcgcaga tcctcgatgc gccggatctt gcccaccgac cgttccagcg
    16801 actccggttc cacgatctcc accgcgaccg acaccccgat gccgtccttc accgccgccg
    16861 cgatggcctg cgcggcggcg tcccgggtct cctgggacgc gtcgggacgg gcctccgccc
    16921 gcacggtgag ggcgtcgaga cggccctccc gggtcagacg caactggaag tggggcgcca
    16981 cacccgggat ccgcagcacg atctcctcga tctgcgtggg gaagagattg actccgcgca
    17041 ggatgaccat gtcgtcactg cgcccggtga tcttctccat ccgccggaac acccgggcgg
    17101 tccccggcag caaccgagtc aagtcccgtg tacggtaccg gatgacgggc atcgcctcct
    17161 tggtgagcga ggtgaagacc agttcgccct cctcgccctc cggcagcacc tcaccggtga
    17221 tcggatccac gatctcgggg aagaagtggt cctcccacac atggagcccg tccttggtct
    17281 ccacacactc ctgcgcgaca ccgggcccga tcacctcgga cagtccgtat atgtcgacgg
    17341 cgtcgatggc gaaccgctcc tcgatctcgc ggcgcatccg ctcggtccag ggttcggcac
    17401 cgaagatgcc cacacgcagg gacgtaccgc gcggatcgac gccctggcgc tcgaactcgt
    17461 cgagaagagt gagcatgtac gacggtgtca ccatgatgat ctcgggcctg aggtcctgga
    17521 tcagctggac ctgccgggcc gtcatcccgc cggacgcggg gatgaccgtg catcccagtc
    17581 tttcggcccc gtagtgtgcg ccgagcccac cggtgaacag cccatatccg taggccacat
    17641 gaaccttgtc cccggggcgt ccgcccgccg cccggatgga tcgggccacc atgtcggacc
    17701 acagggagag gtcggcatcg gtgtagccga cgaccgtggg gcgtccggtg gtgccgctgg
    17761 aggcatggat acggcggata cggtcctgag gcacggcgaa catgccgtac gggtagttct
    17821 ggcgcaggtc ggccttggtg gtgaacggga agcgggccag gtcgccgagt gagcggcagt
    17881 cgtcggggtg cacgccggcc ttgtcgaagg actcccggta gaacggcacg ttgtcgtacg
    17941 cgtgccgcag cgatctccgc aaccgctcca gctgcaactc ccgcagcgcc tccggggcga
    18001 gccgttcccc cgagtccagc agttccgtcg catccgccat ggggaagctc tccctcgcca
    18061 accgcgccat tccgggcgac cgatcattcg gtctgggtgt tcgggatcag taattcagca
    18121 ggagaatgat caggcaaggg ggtggggcgc actttctggg gtcggggggc gcggacaatc
    18181 tccgttgccc ctggtggccg actcggagca ggatcggcgc catgccgacc ttccgcgccg
    18241 ccgacgggac cgagatcgcc taccacctgc gaggggaggg tgaaccgctg ctggtcctcc
    18301 ccggcgggcc gatgcgggcc tcgggctatc tgggagacct cggcggactc gccgcgcacc
    18361 ggcagctggt gctgctcgat ctgcgcggca ccggggactc ggccgagccg gaggacccgg
    18421 ccacctaccg ctgcgaccac atggtggacg acgtcgagat attgcgggcc catatggggc
    18481 gggcccatat ggatgtgttc ggacactcgg cgggcggcag cttggccatg ctgtacgcgg
    18541 ctcggtatcc ggagcgggtg gcgcggctgg tgctggtgac cgcgacgccg tgggcgttgg
    18601 ggatgctgcc cacggtcgag gaccggttgg cagccgcccg gttgcggaag ggcgagccgt
    18661 ggttcgcgga ggcgttggcg gcgttcgagg cgtggctgac cggagcgggc gacttcgacc
    18721 ccgtgttcgc gcccttcttc tacgggcgct gggacgacgc ggcaaagcag catgacgcgc
    18781 gtggcgacgc cgagtacaac gacgaggcct ccggcatcta tggctccgcc ggcgccttcg
    18841 atccaccgag gaccagcaca gaactctccc gcctgaccgc gccgactctc gtcctcgcgg
    18901 gcgaactcga cggatccccc gatccggacc tcgcccgccg caccgccgac gtcttcccga
    18961 acgccgagat cgccgtgcag cccggcgccg ggcaccatcc atggctggac ggcccggagt
    19021 ggttcgtacg ccgtgttgcc gccttcctgg acgggaccgg ccttggaacg ggctgagtca
    19081 ggccccgatg ctgtcggcct cccgcgtaca cgcccgctca gcggttgagg cgacgccgat
    19141 acacgaagaa accggcggtc agcgccagcg cgccgacggc caggccggct ccgagggcca
    19201 cctcgacgtc cgccggcccg gagctgccgc ccagcccgcc ccgcaccccc tgggtgggga
    19261 cggccgaacg tgtgggaagc ggcgccagtg tcggcaacgg cgtgacgatc gagccgcggt
    19321 gcggaaggtg tgcgcaggcg atgccgttgt tcctcccctg gtcccggccc gaacggtcgg
    19381 ggtcgctgaa gccgcggtcg aactcggcct gcgcgtcctc ctggaaggtg aagtcgcggc
    19441 agtccaggtc gccgcgggcg tatgccgcgg gggccgtcgg gccggcgagg gcgagaacgg
    19501 tgatcgcggt cgtgcatatc gcgtggacgc gtcttttcac gggcgttgcc tttcggtccc
    19561 gaggttccga ggtcccgagt tctcgacgac ctctattgcg accgtaggta cgccacccgt
    19621 gcaccgtcgc ctgctgctac gccggacgag ctccgtcact cccgcgtcac ccggacggcc
    19681 catcgacctc cccggtgccg cccttgccgt cccttcagtc ctcgccgctc agccgccctg
    19741 cggaccgtac gccgtcatga agcggtccct gaagcggtcc atgccccagg tcggcgcgtt
    19801 ctcggcgggc ttgaggccgt ccgtccagtg ccagtcggcg atccggtcga ggaccttcgg
    19861 gtcgcgggcg acgacggtga cggggacgtc cttgctggta ctgcccgcgg tgaccgtggg
    19921 gacgggctgg tggtcgccga ggaagacgag gaccgtgtcg tcggtgccgt agcgctggac
    19981 ccactcggtg aggctgtgca gggagtactc gatggcgcgg cggtactcgg tgcggacgcg
    20041 ctcggggtcc tgccagacct ccttggggtc ggtgccctcc ttcttgatct ggtggaagac
    20101 cgagccgtcg cccaggtcgt tccagtcgac catgcgggcg atgggggacc agggattgtg
    20161 gctggaggcc aggatgatct ccgccatgat cgggtctcgg ttcttcttgc cgtgctcaag
    20221 gcgctggaac gcctccaggc tgaactggtc gggcaccggc gtccagctga agtacgggcc
    20281 gtggtagccg aggtgctcgg agtcgtagat gtggtcgagc gcgaagaact tgccctccgg
    20341 ccaggcccgc cgcacccccg gcacgacacc gaccgtccgc catgcgtcgg tcttcctgaa
    20401 gtagctgccc agggtcgcgc gatcgctggt ggtgaggctc cggtaccgct gctggttctt
    20461 gatccagaga ccggagagga acgtggagtg cgcgagccag ctgcccgccc ccgtcaccgg
    20521 cgacttcagc catgcgctgc gcgactggaa cccggccgcc ttgagggtgt tcgtcccctc
    20581 cttgagcgtc gcgtcgatct gcggcgccat cgcggggtcg tcgatcgcga cccggccgta
    20641 gctctcgatg aacgtgaaca gcacgtcctt gccgcgcagc cccgtcagca gttggtccgg
    20701 cggggtcttc gcgaaggcgt cgaccgctgc ctgcttctgg aagatccgtc cgtccttgag
    20761 gcccgcctgc acctgctcga tacggttgtt gacgaagtcg gcgttgccct tggtggcgat
    20821 cgggacaccg gcgatctgga tgcccagggt catacaggtg atccatgcgg tgccgaggac
    20881 cagcgtcgta cgggtggcga tgtgacgatg gccgaccatc aggttcgtca cccgcaccat
    20941 cgcgagcgtc atcaggacga gcaccgcgat gaacaggacc agcactccga ccaccgcgag
    21001 cacctgcc
//
