LOCUS       NZ_BNBM01000005        10405 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence05, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000005
VERSION     NZ_BNBM01000005.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 542353)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 440680
            Orig. end                         :: 451085
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5405)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    376..391
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.92"
                     /tool="antismash"
     gene            504..1220
                     /locus_tag="IE325_RS16865"
                     /old_locus_tag="GCM10018780_34100"
     CDS             504..1220
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004002241.1"
                     /locus_tag="IE325_RS16865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34100"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_190070717.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALEAFPHRDQVEVVHRSFELDP
                     GRAKGDIQPVITMLTKKYGMSAAQAQAGEENLGAQAAAEGLAYRTQGRDHGNTFDMHRL
                     LHLAKEQGRQDALIQALYKANFAEERSLFSEGDERLVELAVAAGLDADDARKVLADPDA
                     YADDVRADEREAAQLGANGVPFFVLDRKYGVSGAQPAEVFEQALTQAWGERSPLQLIDQ
                     GDADACGPDGCAVPQN"
     gene            1316..2365
                     /locus_tag="IE325_RS16870"
                     /old_locus_tag="GCM10018780_34110"
     CDS             1316..2365
                     /NRPS_PKS="Domain: Aminotran_5 (16-291). E-value: 6.6e-23.
                     Score: 73.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS16870_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006375070.1"
                     /locus_tag="IE325_RS16870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34110"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_229911840.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-18, bitscore:
                     61.8, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFESLVRTEFAPKNTYLNTASTGLVPARTVAAMRTAVEAAAVG
                     RPTDMFADVEASRASFARLVGVPGHRVAAGASVAVYSGLIAASLPSGAEVLTAEGDFSS
                     VVNPFHVRSDLKVRTVPLERVAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGT
                     RTYIDASQATGWLDFDADAYDYSASVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAG
                     EHPWDACYGPIDELADSARRFDESPALFSYAGARRSLELLEELGVDAVRAHDLALADRF
                     RAGLASLGHEPVPSPGSPIVSVPGLGHRQAGLSSAGVEVSDRAGNLRAAFHLYNTPADV
                     DRLLDVLSA"
     aSDomain        1364..2188
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS16870_Aminotran_5.1"
                     /evalue="6.60E-23"
                     /label="IE325_RS16870_Aminotran_5.1"
                     /locus_tag="IE325_RS16870"
                     /protein_end="291"
                     /protein_start="16"
                     /score="73.1"
                     /tool="antismash"
                     /translation="TYLNTASTGLVPARTVAAMRTAVEAAAVGRPTDMFADVEASRASF
                     ARLVGVPGHRVAAGASVAVYSGLIAASLPSGAEVLTAEGDFSSVVNPFHVRSDLKVRTV
                     PLERVAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGTRTYIDASQATGWLDFD
                     ADAYDYSASVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAGEHPWDACYGPIDELAD
                     SARRFDESPALFSYAGARRSLELLEELGVDAVRAHDLALADRFRAGLASLGHE"
     gene            2426..3031
                     /locus_tag="IE325_RS16875"
                     /old_locus_tag="GCM10018780_34120"
     CDS             2426..3031
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436208.1"
                     /locus_tag="IE325_RS16875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34120"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_190070719.1"
                     /transl_table=11
                     /translation="MESTGVTSAPPPADAEVHRRLVYGDESALAEVYTAYGGLVRRVAV
                     RVTRSPVAAEDVAQEVFAHLWSRPYTFDARRGSLRTWLSVLAHRRAVDWVRSEARHRKD
                     AGADDSALQAIPDAGPGPDETVVDRERSLLLHSALAELPQPQREVVHLAYFAGRTYRQA
                     AVELGIPEGTAKTRLRSALRSLAETLADPPDPALERGA"
     gene            3080..4084
                     /locus_tag="IE325_RS16880"
                     /old_locus_tag="GCM10018780_34130"
     CDS             3080..4084
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477735.1"
                     /locus_tag="IE325_RS16880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34130"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_190070720.1"
                     /transl_table=11
                     /translation="MTDDEHEAVRDLLAAWAFGALDPAEEETLAPHLAECESCAAQAAR
                     LRETVRLLDGPEPSAPAGRNNGALSLALRARPTGPRVAAHAAPYAAAVAGLKALLPELE
                     GRWTTPVVHDWDAHATVAHLLAADEHLAGELGVDARVPPSRIEEGTHWEDAWNRRSADV
                     IAHEHGRTPEETVADWAAQADALLATAQAHDPELAARAVTLMGMRLPVADHFLVRGFET
                     WIHTDDLGRALGLAVPPPPPEHLERLVRLAVRVLGLALGPTAPPVLFSVTGDEEWVLGS
                     ADEPVQAELTLDPYDFCLLVGGRYAPETVPRGQNGDAAAVRNVLERAASLSWL"
     gene            complement(4097..4993)
                     /gene="thpD"
                     /locus_tag="IE325_RS16885"
                     /old_locus_tag="GCM10018780_34140"
     CDS             complement(4097..4993)
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448161.1"
                     /locus_tag="IE325_RS16885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34140"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_190070721.1"
                     /sec_met_domain="PhyH (E-value: 8e-42, bitscore: 138.8,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTSPVTDLYPSRGATEVSTPRQDPVVWGSPGTPGPIAAGELSS
                     FERDGFLAIDQLIGADEVAVYHQELERLVNDPAIRMDERSIVEPKSKEIRSVFEVHRIS
                     EVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPN
                     MRTVSVSIALTENYDTNGGLMIMPGSHRTFLGCAGATPKDNYKKSLQMQDAGTPSDEAL
                     TRMASEYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFSA
                     PVRRPEFIGARDFTPVR"
     gene            complement(5001..5405)
                     /locus_tag="IE325_RS16890"
                     /old_locus_tag="GCM10018780_34150"
     CDS             complement(5001..5405)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="IE325_RS16890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34150"
                     /product="ectoine synthase"
                     /protein_id="WP_190070722.1"
                     /sec_met_domain="ectoine_synt (E-value: 7.8e-55, bitscore:
                     179.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKSASGTWESKRIVLAKEKVGFSLHETILY
                     AGTETSMWYANHIEAVVCVEGEAELTDHETGRTHVITSGTMYLLDGHERHTLRVKKDFR
                     CICVFNPPVTGREDHDENGVYPLLTEPEEV"
     gene            complement(5454..6725)
                     /gene="ectB"
                     /locus_tag="IE325_RS16895"
                     /old_locus_tag="GCM10018780_34160"
     CDS             complement(5454..6725)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 9e-73.
                     Score: 237.1. Matches aSDomain:
                     nrpspksdomains_IE325_RS16895_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="IE325_RS16895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34160"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_190070723.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.1e-76, bitscore:
                     253.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRARGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTSAKRAFLQTFQDLVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     AWLRALAELCERQDMLLIVDDIQMGCGRTGAFFSFEESGITPDIVTVSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTATAALESYWADGSAMEKQTRARGEQVEQGL
                     IAICEENPADVKEYRGRGLVWGMEFHDKERAGRAAQRAFELGLLVETSGPESEVLKLLP
                     ALTITPDELDEGLRVLARAVTETA"
     aSDomain        complement(5628..6641)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS16895_Aminotran_3.1"
                     /evalue="9.00E-73"
                     /label="IE325_RS16895_Aminotran_3.1"
                     /locus_tag="IE325_RS16895"
                     /protein_end="366"
                     /protein_start="28"
                     /score="237.1"
                     /tool="antismash"
                     /translation="FDRARGSRMYDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVTHGLDMSTSAKRAFLQTFQDLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARPAWLRALAELCERQDMLLIVDDIQMGCGR
                     TGAFFSFEESGITPDIVTVSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TATAALESYWADGSAMEKQTRARGEQVEQGLIAICEENPADVKEYRGRGLVWGMEFH"
     gene            complement(6757..7263)
                     /gene="ectA"
                     /locus_tag="IE325_RS16900"
                     /old_locus_tag="GCM10018780_34170"
     CDS             complement(6757..7263)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004002246.1"
                     /locus_tag="IE325_RS16900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34170"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_190070724.1"
                     /transl_table=11
                     /translation="MTAAQADLQIDRPAVADGAALWRIARDSEALDLNSSYSYLLWCRD
                     FAGTSAVARDERGEPVGFITGYVRPDRPHTLLVWQVAVDDAQRGRGIAAALLDGLAARV
                     CGEYGVTGIETTITPGNTASERLFGSFAERHGAALEREVLFPTSLFPDGPHDPEVLYRI
                     GPLSL"
     misc_feature    complement(7296..7309)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.46"
                     /tool="antismash"
     misc_feature    complement(7418..7433)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    7437..7453
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.64"
                     /tool="antismash"
     misc_feature    complement(7456..7470)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.0"
                     /tool="antismash"
     misc_feature    complement(7547..7561)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.73"
                     /tool="antismash"
     gene            complement(7570..8097)
                     /locus_tag="IE325_RS16905"
                     /old_locus_tag="GCM10018780_34180"
     CDS             complement(7570..8097)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010355555.1"
                     /locus_tag="IE325_RS16905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34180"
                     /product="DinB family protein"
                     /protein_id="WP_190070725.1"
                     /transl_table=11
                     /translation="MPTDTTLTLPDGRPIPRLTGPERPMLESWLDFHRATLELKCAGLD
                     DTQVRQESAEPSELTLLGLVQHLAECERNWFQRVAGGLDVPPVYEEETGYALNPERGID
                     EALTTWRREIERGRQVCAGRTLESVGRITDGPMAGVEVGLRWVFIHMIEEYARHNGHAD
                     ILRERIDGVTGA"
     gene            complement(8378..9478)
                     /locus_tag="IE325_RS16910"
                     /old_locus_tag="GCM10018780_34190"
     CDS             complement(8378..9478)
                     /NRPS_PKS="Domain: Aminotran_5 (74-311). E-value: 2e-28.
                     Score: 91.3. Matches aSDomain:
                     nrpspksdomains_IE325_RS16910_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037833.1"
                     /locus_tag="IE325_RS16910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_34190"
                     /product="alanine--glyoxylate aminotransferase family
                     protein"
                     /protein_id="WP_190070726.1"
                     /sec_met_domain="Aminotran_5 (E-value: 7e-23, bitscore:
                     76.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTAARFASIEDRVARLLDTRQDVVIMQGEALLPLE
                     GAIRGTAGPGTTALNVITGPYGQTFGNWLRDCGATVIDLAVPFHTAVTADQIRAAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPSAPRRSYLSLLDWKERWIDGGRTALPHAP
                     AQLEMLALEACVERIEGDGLEAVMARHRAAASSTRAGVVALGGGLEPYVHDAREAAPVA
                     TTLRVPAGVVASEVVARVLAAEPGLPLAAGGGGLAREMIRVNHYGVDAGVGVVRGCVAA
                     LGAVLGELGMGVDVGAAVGVVEAGWR"
     aSDomain        complement(8546..9256)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS16910_Aminotran_5.1"
                     /evalue="2.00E-28"
                     /label="IE325_RS16910_Aminotran_5.1"
                     /locus_tag="IE325_RS16910"
                     /protein_end="311"
                     /protein_start="74"
                     /score="91.3"
                     /tool="antismash"
                     /translation="RDCGATVIDLAVPFHTAVTADQIRAAFAEHPEIDFVSLVHAEAAT
                     GNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVSA
                     VSVSERAWARMAANPSAPRRSYLSLLDWKERWIDGGRTALPHAPAQLEMLALEACVERI
                     EGDGLEAVMARHRAAASSTRAGVVALGGGLEPYVHDAREAAPVATTLRVPAGVVASEVV
                     ARVLAAEPGLPLAAG"
     misc_feature    9479..9493
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.11"
                     /tool="antismash"
     misc_feature    complement(9909..9924)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.89"
                     /tool="antismash"
ORIGIN
        1 tgcacgcgcg ggcccgggcg acgtactacc ccgacgggct gccgcaggac ggcaccgact
       61 ggaccgccgc ctggcaggag gccatcgccc ggccggacgg gcatgtgctg tgcgtggtgg
      121 aggaggggcg gatcgtcggg ctggcgtcct tccgtacgcc cgagggtgcc gccgtcgaca
      181 cggtcaagct gttccagttc catgtcgacc ccgagcactg gcgccgcggt gtcggtacgg
      241 cgctgcacgc ggcctgtctg gaggagtggc gggccgacgg caagcgcacc gccgtgctcg
      301 acgtgcatgt ggacaaccgg cgcgcccagg ccttctacgc cggccgggga tggctgcccg
      361 accccgagaa cccgcccgcc gagggcgatc accatctgta tctgaggttc tccgtgaccg
      421 gggaatgaag cccgctgctt gaacgttcac ccactcggcg gagggtgtct ccgtatccgt
      481 tcgagctgga gagagccgaa gacatgcgcg tcgagatctg gagcgacatc gcctgcccct
      541 ggtgctatgt gggcaaggcc cgcttcgaga aggcgctgga ggccttcccg caccgcgacc
      601 aggtcgaggt ggtgcaccgt tccttcgaac tggaccccgg gcgcgccaag ggtgacatcc
      661 agcccgtgat caccatgctc acgaagaagt acggcatgag cgccgcgcag gcccaggccg
      721 gtgaggagaa cctcggcgcg caggccgccg cggaggggct cgcgtaccgc acccagggcc
      781 gcgaccacgg caacaccttc gacatgcacc ggctgctgca cctcgccaag gagcagggcc
      841 ggcaggacgc gctgatccag gccctgtaca aggcgaactt cgccgaggag cggtccctgt
      901 tctccgaggg cgacgagcgg ctcgtggagc tggccgtggc cgccgggctc gacgccgacg
      961 acgcccgcaa ggtcctcgcc gaccccgacg cctacgccga cgacgtccga gccgacgagc
     1021 gtgaggccgc ccagctcggg gccaacggcg tgcccttctt cgtcctcgac cgcaagtacg
     1081 gcgtctccgg cgcccagccc gcagaggtct tcgagcaggc cctgacacag gcctggggcg
     1141 agcggtcgcc gcttcagctc atcgaccagg gtgacgcgga cgcgtgcggc cccgacgggt
     1201 gcgcggtgcc gcagaactaa aagcgcaggt gacggcggat ctataaggac tgcttggcga
     1261 aaccacgcag aaatagtcaa tggactatca gttctcccgg gcccagagtg gagccatgga
     1321 gaccttcgag agcctcgtcc gtaccgagtt cgcgccgaag aacacctacc tgaacacggc
     1381 cagtaccggc ctggtaccgg cccgcaccgt cgccgccatg cggaccgccg tggaggccgc
     1441 ggccgtcgga cggccgaccg acatgttcgc cgacgtagag gcgagccgcg cctccttcgc
     1501 gcggctcgtc ggcgtgcccg ggcaccgggt ggcggccggg gcctccgtcg ccgtctacag
     1561 cggcctgatc gccgcctccc tcccgtcggg cgccgaagtc ctcaccgccg agggcgactt
     1621 cagctccgtc gtgaacccct tccacgtccg ctccgacctc aaggtgcgca ccgtgccgct
     1681 ggagcgggtc gccgagtcgg tgcggcccgg caccgccctg gtcgcggtca gcgccgcgca
     1741 gtccgccgac ggccgggtcg ccgacctgcc cgcgatccgt gaggcggccc gcgaacacgg
     1801 cacacgtacg tacatcgacg cgtcccaggc caccggatgg ctggacttcg acgcggacgc
     1861 ctacgactac tccgcctccg tcgccttcaa gtggctcgtc tgcccacggg gcgtggcctt
     1921 cctggtcgtc ccggaggacc tcggcggact caccccgctc ttcgccggct gggtcgcggg
     1981 ggaacacccc tgggacgcct gctacggccc catcgacgaa ctcgccgact ccgcacggcg
     2041 gttcgacgag agccccgccc tcttctccta cgccggcgcc cgccgctccc tcgaactgct
     2101 ggaggaactg ggcgtggacg ccgtacgcgc ccatgacctc gccctcgccg accgcttccg
     2161 cgcgggcctc gcctccctcg gccacgagcc cgtcccgtcg cccggctcgc cgatcgtctc
     2221 cgtgcccgga ctcggccacc gccaggccgg gctgagcagc gccggagtcg aggtctccga
     2281 ccgcgcgggc aacctccgcg cggccttcca cctctacaac acgcccgccg acgtcgaccg
     2341 cctcctcgac gtcctctccg cctgaaccga cccgaaccga cccgaaccac tggcgcggga
     2401 ccagccggga cgctaggaag ggcacgtgga gtccacgggt gtcacctccg caccgccgcc
     2461 tgccgacgcg gaggtgcacc ggcggctggt gtacggcgac gagtccgcgc tggccgaggt
     2521 gtacacggcg tacggcgggc tggtgcggcg ggtcgccgtg cgtgtcaccc gctccccggt
     2581 cgccgccgag gacgtggcgc aggaggtctt cgcccacctg tggagccggc cgtacacctt
     2641 cgacgcgcgc cgcggctcgc tgcgcacctg gctgtccgtg ctcgcccacc ggcgggccgt
     2701 ggactgggtg cgcagcgagg ccaggcaccg caaggacgcc ggcgccgacg actcggcgct
     2761 ccaggccatc cccgacgccg gccccggccc cgacgagacg gtcgtggacc gcgaacgctc
     2821 cctcctcctg cactccgccc tcgccgaact cccgcagcca cagcgcgagg tcgtgcacct
     2881 cgcctacttc gccggccgca cctaccggca ggccgcagtg gaactgggca taccggaggg
     2941 caccgccaag acccggctgc gcagcgccct gcgctccttg gcggaaactt tggccgaccc
     3001 gccggacccg gcgctcgaaa ggggcgcatg atggcgagag gggtacccgt agggaacggg
     3061 cacggagagg aggcgcgcga tgaccgacga cgagcacgaa gccgtacgtg acctgctggc
     3121 cgcgtgggcc ttcggcgccc tcgacccggc cgaggaggag accctggccc cgcacctggc
     3181 cgagtgcgag agctgcgcgg cccaggcggc acggctgcgg gagacggtac gcctgctgga
     3241 cgggccggag ccgagcgctc ccgccgggcg gaacaacggc gcgctctccc tcgccctgcg
     3301 cgcccgcccc accggccctc gcgtcgccgc gcacgccgcc ccctacgccg ccgcggtcgc
     3361 cgggctcaag gcactgctgc ccgagctgga aggccgctgg accacgccgg tcgtgcacga
     3421 ctgggacgcg cacgccaccg tcgcccacct cctcgccgcc gacgagcacc tggctggcga
     3481 gctcggcgtc gacgcgcgtg tgccgccctc gcggatcgag gagggcacgc actgggagga
     3541 cgcctggaac cgccgcagcg ccgatgtcat cgcccatgag cacggccgta ctcccgagga
     3601 gaccgtggcc gactgggccg cgcaggccga cgcgctgctc gccaccgctc aggcccacga
     3661 tccggaactc gccgcgcggg ccgtgacgct gatggggatg cggctgcccg tcgccgacca
     3721 cttcctggtg cgcggcttcg agacctggat ccacaccgac gacctcggcc gcgccctggg
     3781 cctcgccgtc ccgccgccac cgccggagca cctggagcgg ctggtccgcc tcgccgtgcg
     3841 cgtcctcgga ctggccctcg gacccaccgc gcccccggtg ctgttctcgg tcaccgggga
     3901 cgaggaatgg gtgctgggct ccgcggacga gcccgtacag gccgaactca cccttgatcc
     3961 gtacgacttc tgcctgctgg tcggcggacg gtacgccccg gagacggtgc ccaggggaca
     4021 gaacggcgac gcggccgccg tacggaacgt actggagcgg gccgcgtcgc tgtcctggct
     4081 ctgaccggtt acctcgttac ctcaccgggg tgaagtcccg ggcgccgatg aactccggcc
     4141 gccgtaccgg agccgagaag ggctccacgg ccgtgttctc cacgctgttg aacacgatga
     4201 acacattgct gcgcgggaac ggcgtgatgt tgtcgccgga gccgtgcatg cagttgcagt
     4261 cgaaccaggt cgccgaaccg gccttgcccg tgaagagctt gatgccgtac tcggaggcca
     4321 tccgcgtcag cgcctcgtcg gacggcgtgc ccgcgtcctg catctgcagg gacttcttgt
     4381 agttgtcctt cggcgtggct cccgcgcacc cgaggaaggt gcggtgcgag ccgggcatga
     4441 tcatcagccc gccgttggtg tcgtagttct cggtcagcgc gatcgagacg gacaccgtcc
     4501 gcatgttcgg cagaccgtcc tcggcgtgcc aggtctcgaa gtccgagtgc cagtagaagc
     4561 cgctcgcccc gaagcccggc ttgacgttga tccgcgactg gtggacgtac acgtccgagc
     4621 cgaggatctg ccgggcccgg ccgacgaccc gctcgtcgcg cacgagcttc gcgaacacct
     4681 cgctgatgcg gtgcacctcg aagacggagc ggatctcctt ggacttcggc tcgacgatgg
     4741 agcgttcgtc catacggatc gccgggtcgt tgacgaggcg ctccagctcc tggtggtaga
     4801 ccgcgacctc gtcggcgccg atcagctggt cgatggcgag gaagccgtca cgctcgaagg
     4861 acgacagttc accggccgcg atcgggcccg gtgtgccggg ggagccccag acgacggggt
     4921 cctggcgcgg ggtcgacacc tcggtggcgc cgcggctggg gtagagatcg gtgacgggag
     4981 acgttgtcgt catggggttc tcacacctcc tcgggctcgg tgagcagcgg gtacacgccg
     5041 ttctcgtcgt ggtcctcccg gccggtcacg ggcgggttga agacacagat gcagcggaag
     5101 tccttcttga cccgcagcgt gtgcctctcg tgcccgtcca ggaggtacat ggtcccggac
     5161 gtgatcacat gcgtccgccc ggtctcgtgg tcggtcagct cggcctcgcc ctcgacgcag
     5221 acgacggcct cgatgtggtt cgcgtaccac atcgacgtct ccgtacccgc gtacaggatc
     5281 gtctcgtgca gggagaagcc gaccttctcc ttggcgagga cgatgcgctt gctctcccag
     5341 gtgccggacg ccgatttcac atggcggtcg gtgccttcga tgtccttgaa cgaacggacg
     5401 atcacggtgc tgcgatgcct cctaggtggg gttttctcgg tacgcgaccg cgctcaggcg
     5461 gtctcggtga cggcccgggc gaggacgcgg agcccttcgt ccagctcgtc gggggtgatg
     5521 gtcagggcgg ggagcagctt gaggacctcg ctctccgggc cggacgtctc caccaggagc
     5581 ccgagctcga aggcgcgctg cgcggcgcgc ccggcccgct ccttgtcgtg gaactccatg
     5641 ccccacacca ggccgcggcc ccggtactcc ttgacgtcgg cggggttctc ctcgcagatg
     5701 gcgatcagcc cctgctcgac ctgctcgccg cgcgcccggg tctgcttctc catcgccgag
     5761 ccgtcggccc agtacgactc cagggcggcg gtggcggtga cgaaggcggg gttgttgccg
     5821 cggaaggtgc cgttgtgctc gcccggctcc cagatgtcca gctcgggctt gaacaggcac
     5881 agcgacatgg gcagtccgta gccgctgatg gacttggaga cggtgacgat gtccggggtg
     5941 atgcccgact cctcgaagga gaagaaggcc cctgtccgcc cgcaccccat ctggatgtcg
     6001 tccacgatga gcagcatgtc ctgccgctcg cacagctcgg cgagcgcacg cagccacgcg
     6061 ggacgcgcga cgttgatgcc gccctcgccc tgcacggtct ccacgatcac ggcggccggc
     6121 ttgttgagcc cggacccctg gtcctccagg agccgctcga accacaggaa gtccgggacg
     6181 gtgccgtcga agtagttgtc gaacggcatc ggcgtgccgt gcaccagcgg gatgccggcg
     6241 ccggcccgct tgaaggcgtt gccggtgacg gcgagcgagc ccagcgacat cccgtggaag
     6301 gcgttggtga acgacacgat ggcctcgcgc cccttcacct tccgggccag cttgagcgcc
     6361 gactcgacgg cgttggtgcc cgtcgggccc gggaacatga ccttgtacgg caggtcgcgc
     6421 ggccgcagca ccaggtcctg gaaggtctgc aggaaggccc gcttggcgct ggtcgacatg
     6481 tcgagcccgt gcgtgacgcc gtcacgctcc aggtagtcga tcaacgcccg tttcaggacc
     6541 gggttgttgt gcccgtagtt cagcgagccc gcgccggcga agaagtccag gtactcgtgg
     6601 ccgtcctcgt cgtacatacg gctgccccga gcacggtcga agacggtggg ccagccgcgg
     6661 cagtagctgc gcacctcgga ctccagggtc tcgaagacgc tgaggtcggg ctgggtgatg
     6721 gtcacgacga atcgctcctc gttgcgtggg gggaggtcag agggagaggg gaccgatgcg
     6781 gtacaggact tcggggtcgt gcgggccgtc cgggaacagg ctggtgggga acagcacctc
     6841 gcgctccagg gcggcgccgt gccgctccgc gaaggagccg aacaggcgct cggaggcggt
     6901 gttgccgggc gtgatggtgg tctcgatgcc ggtgacgccg tactcgccgc agacccgcgc
     6961 ggcgagcccg tcgagcagtg cggcggcgat gccgcggccg cgctgggcgt cgtcgacggc
     7021 gacctgccag acgagcaggg tgtgcgggcg gtccgggcgt acgtacccgg tgatgaagcc
     7081 gaccggctcc ccgcgctcgt cacgagcgac ggccgacgtg ccggcgaagt cgcggcacca
     7141 cagcagatag ctgtacgacg agttgaggtc gagggcttcg gagtctctgg ctatccgcca
     7201 cagcgcggcc ccgtcggcca ccgccggacg gtcgatttgc aggtctgctt gtgcggcagt
     7261 catgcgaatt gaatttaccg agggaaaatt gaaattgcat ggccgtacgg ggttacgcgt
     7321 ggtggcgcga tgtgttatca cgcgggcgtg aggagcactg cggtgacctg gtggtatgca
     7381 cctttcgccc cggtaatttc acgcaaatcg gacgggatgt ggaacgcatc acagggttgt
     7441 aactctcctg gaacctgtcc gaatcagtcc gataggtgtt cgcggaattt ttgcgtttag
     7501 gttccgggaa agcgggcaga agacgatggg aagctgccct cgaaaagaat ttctggaata
     7561 accctgaatt caggctccgg taacaccgtc gatacgctct cgcagaatgt cggcgtggcc
     7621 gttgtgccgg gcgtactcct cgatcatatg aatgaacacc cagcgcagac cgacctcgac
     7681 cccggccatc ggtccgtccg tgatccgacc cacactctcc agcgtccggc ccgcgcacac
     7741 ctggcgccct cgctcgatct cccgccgcca ggtcgtgagc gcctcgtcga tgccgcgctc
     7801 ggggttgagc gcgtatccgg tctcctcctc gtacaccggc ggcacgtcga gcccgcccgc
     7861 cacccgctgg aaccagttcc gctcacactc cgcgaggtgc tgcaccaggc cgagcagggt
     7921 cagctccgac ggctcggcgg attcttggcg cacctgtgtg tcgtccaggc ccgcgcactt
     7981 cagctccagg gtggcgcggt ggaagtccag ccagctttcg agcatggggc gctcggggcc
     8041 ggtgaggcgg gggatggggc ggccgtcggg gagggtgagg gtggtgtcgg tgggcatgtg
     8101 gggagcatgg cagggcgggg ggttgtgggc gaggtggttc ttggtggagg ggccttttct
     8161 cgccccgccg cccctacccg tcccatcctg gggctccgcc ccagaccccg ctcctcaaac
     8221 gccggagggg ctgagtttca gcgaccgccg gaggggctgg gtttttcagc ccgtccggcg
     8281 tttgaggacg aggcccgttc agggccgaag cgggggtccg ggggcggcag cccccgggga
     8341 cgggacgggt aggggcggcg ggggcgaaaa aaccccgcta ccgccaaccc gcctccacca
     8401 cccccaccgc cgcccccaca tccacaccca tccccagttc ccccaacacg gcccccaacg
     8461 ccgccacaca cccccgcacg acccccaccc ccgcatccac cccatagtga ttgacccgga
     8521 tcatctccct ggccaacccc ccacccccgg cagccagcgg caaccccggc tcggcagcca
     8581 acacccgcgc caccacctcc gacgccacca cccccgccgg cacccgcagc gtcgtagcga
     8641 ccggagccgc ctcgcgggca tcgtggacgt acggctcaag acccccgccc agcgccacca
     8701 ccccggcccg cgtcgacgag gccgccgcac gatggcgggc catcaccgcc tccagcccgt
     8761 ccccctcgat ccgctccacg cacgcctcca gcgccagcat ctccagctgc gcgggcgcat
     8821 gcggcagcgc cgtgcgcccg ccgtcgatcc accgctcctt ccagtccagc aaggacagat
     8881 acgacctccg cggcgccgag gggttcgccg ccatccgcgc ccacgcccgc tcgctcacgg
     8941 acaccgccga caccccggca ggcccgccca tcgccttctg cgccccgatc acacacaggt
     9001 ccacacccca cgcgtccggc agcaccggct cggcgccgat cgacgccacc gcgtccaggt
     9061 agaacagcgc cccgtgcgcc cgcacgacct cgccgatctc cgcgacggga ttggtgttgc
     9121 cggtcgccgc ctccgcgtgc accagcgaga cgaagtcgat ctccgggtgc tcggcgaagg
     9181 cggcacggat ctggtccgcc gtcaccgccg tatggaaggg caccgccaga tcgatcaccg
     9241 tcgcgccgca gtcccgcagc cagttcccga aggtctgccc gtaaggaccg gtgatcacgt
     9301 tcagcgcggt cgtaccgggc ccggccgtcc cccggatcgc cccctccagc ggcagcagcg
     9361 cctcaccctg catgatcacg acgtcctgcc gggtgtccag cagccgcgcc acccggtcct
     9421 cgatcgaggc gaagcgcgcg gcggtcagcg gaggcagatc gaggaacggg tgggtcatgg
     9481 agagcgctcg cattcttcgt agaagttctg ggcggtggag gtctactccg ccgatcttag
     9541 gtagaacggc tccacagcca tcggtttggt ttgaggtact caaacccttc cttataatcg
     9601 gaacccacag ttccctgaca ggaggctccc cgtgaagacg accctcgggc gccggacccg
     9661 cgttctggcc gccaccaccg cgacggccgg gctggtgctc gtggccggct gctcctccga
     9721 cgacagcggt ggcggtggca cgaagacggc cgccggcggt gtcgagctcg tcaaggcggg
     9781 ccagctcacc acctgcaccc acctgcccta cccgcccttc cagtcggaga tcgacggcaa
     9841 ggtgcagggc ttcgacgtct cgctgatcga cctggtcgcg gacgacctgg gagtgaagca
     9901 ggtcatcgtc gaccagccct tcgagaactt caagaccggc ggctctctca acgccggcag
     9961 ctgcgacctc gccgccgccg gcatgaccat caccgaggag cgcaagaaga acgtcgactt
    10021 ctccgacccg tacttcgacg ccacccaggc cgtcctggtc gacaagaaga gcggcatcac
    10081 gtccttcgcc ggtctcaagg gcaagaaggt cggcgcccag gcgcagacca ccggtgagga
    10141 ctacgccaag agcaagggcc tggacccggt gtccttcgag tcctccgacg ccgtcatcaa
    10201 cggcctgcgc tccggccagg tcgaggccgt cgtcatcgac tacccggtcg tccagggctg
    10261 gctgaaggac aaggccaacg ccgacgcctt caaggtcgcc gagcaggtca acaccggcga
    10321 gcagtacggc ttcacggtga agaagggcaa caccaagctc ctcgcggcca tcaacaaggc
    10381 cctcacggac gcgaaggccg acggt
//
