LOCUS NZ_BNBM01000005 10405 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence05, whole genome shotgun sequence. ACCESSION NZ_BNBM01000005 VERSION NZ_BNBM01000005.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 542353) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 440680 Orig. end :: 451085 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000005.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..10405 /candidate_cluster_numbers="1" /contig_edge="False" /product="ectoine" /region_number="1" /rules="ectoine_synt" /tool="antismash" cand_cluster 1..10405 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="ectoine_synt" /kind="single" /product="ectoine" /protoclusters="1" /tool="antismash" protocluster 1..10405 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[5000:5405](-)" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" /tool="antismash" proto_core complement(5001..5405) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" misc_feature 376..391 /note="TFBS match to ClgR, Caseinolytic protease gene regulator, confidence: weak, score: 22.92" /tool="antismash" gene 504..1220 /locus_tag="IE325_RS16865" /old_locus_tag="GCM10018780_34100" CDS 504..1220 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004002241.1" /locus_tag="IE325_RS16865" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34100" /product="DsbA family oxidoreductase" /protein_id="WP_190070717.1" /transl_table=11 /translation="MRVEIWSDIACPWCYVGKARFEKALEAFPHRDQVEVVHRSFELDP GRAKGDIQPVITMLTKKYGMSAAQAQAGEENLGAQAAAEGLAYRTQGRDHGNTFDMHRL LHLAKEQGRQDALIQALYKANFAEERSLFSEGDERLVELAVAAGLDADDARKVLADPDA YADDVRADEREAAQLGANGVPFFVLDRKYGVSGAQPAEVFEQALTQAWGERSPLQLIDQ GDADACGPDGCAVPQN" gene 1316..2365 /locus_tag="IE325_RS16870" /old_locus_tag="GCM10018780_34110" CDS 1316..2365 /NRPS_PKS="Domain: Aminotran_5 (16-291). E-value: 6.6e-23. Score: 73.1. Matches aSDomain: nrpspksdomains_IE325_RS16870_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006375070.1" /locus_tag="IE325_RS16870" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34110" /product="aminotransferase class V-fold PLP-dependent enzyme" /protein_id="WP_229911840.1" /sec_met_domain="Aminotran_5 (E-value: 1.5e-18, bitscore: 61.8, seeds: 34, tool: rule-based-clusters)" /transl_table=11 /translation="METFESLVRTEFAPKNTYLNTASTGLVPARTVAAMRTAVEAAAVG RPTDMFADVEASRASFARLVGVPGHRVAAGASVAVYSGLIAASLPSGAEVLTAEGDFSS VVNPFHVRSDLKVRTVPLERVAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGT RTYIDASQATGWLDFDADAYDYSASVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAG EHPWDACYGPIDELADSARRFDESPALFSYAGARRSLELLEELGVDAVRAHDLALADRF RAGLASLGHEPVPSPGSPIVSVPGLGHRQAGLSSAGVEVSDRAGNLRAAFHLYNTPADV DRLLDVLSA" aSDomain 1364..2188 /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS16870_Aminotran_5.1" /evalue="6.60E-23" /label="IE325_RS16870_Aminotran_5.1" /locus_tag="IE325_RS16870" /protein_end="291" /protein_start="16" /score="73.1" /tool="antismash" /translation="TYLNTASTGLVPARTVAAMRTAVEAAAVGRPTDMFADVEASRASF ARLVGVPGHRVAAGASVAVYSGLIAASLPSGAEVLTAEGDFSSVVNPFHVRSDLKVRTV PLERVAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGTRTYIDASQATGWLDFD ADAYDYSASVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAGEHPWDACYGPIDELAD SARRFDESPALFSYAGARRSLELLEELGVDAVRAHDLALADRFRAGLASLGHE" gene 2426..3031 /locus_tag="IE325_RS16875" /old_locus_tag="GCM10018780_34120" CDS 2426..3031 /GO_function="GO:0016987 - sigma factor activity [Evidence IEA]" /GO_process="GO:0006352 - DNA-templated transcription initiation [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1032: RNA polymerase, sigma-24 subunit, ECF subfamily" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016436208.1" /locus_tag="IE325_RS16875" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34120" /product="RNA polymerase sigma factor" /protein_id="WP_190070719.1" /transl_table=11 /translation="MESTGVTSAPPPADAEVHRRLVYGDESALAEVYTAYGGLVRRVAV RVTRSPVAAEDVAQEVFAHLWSRPYTFDARRGSLRTWLSVLAHRRAVDWVRSEARHRKD AGADDSALQAIPDAGPGPDETVVDRERSLLLHSALAELPQPQREVVHLAYFAGRTYRQA AVELGIPEGTAKTRLRSALRSLAETLADPPDPALERGA" gene 3080..4084 /locus_tag="IE325_RS16880" /old_locus_tag="GCM10018780_34130" CDS 3080..4084 /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_005477735.1" /locus_tag="IE325_RS16880" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34130" /product="maleylpyruvate isomerase family mycothiol-dependent enzyme" /protein_id="WP_190070720.1" /transl_table=11 /translation="MTDDEHEAVRDLLAAWAFGALDPAEEETLAPHLAECESCAAQAAR LRETVRLLDGPEPSAPAGRNNGALSLALRARPTGPRVAAHAAPYAAAVAGLKALLPELE GRWTTPVVHDWDAHATVAHLLAADEHLAGELGVDARVPPSRIEEGTHWEDAWNRRSADV IAHEHGRTPEETVADWAAQADALLATAQAHDPELAARAVTLMGMRLPVADHFLVRGFET WIHTDDLGRALGLAVPPPPPEHLERLVRLAVRVLGLALGPTAPPVLFSVTGDEEWVLGS ADEPVQAELTLDPYDFCLLVGGRYAPETVPRGQNGDAAAVRNVLERAASLSWL" gene complement(4097..4993) /gene="thpD" /locus_tag="IE325_RS16885" /old_locus_tag="GCM10018780_34140" CDS complement(4097..4993) /EC_number="1.14.11.55" /GO_function="GO:0016706 - 2-oxoglutarate-dependent dioxygenase activity [Evidence IEA]" /codon_start=1 /gene="thpD" /gene_functions="biosynthetic-additional (rule-based-clusters) PhyH" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007448161.1" /locus_tag="IE325_RS16885" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34140" /product="ectoine hydroxylase" /protein_id="WP_190070721.1" /sec_met_domain="PhyH (E-value: 8e-42, bitscore: 138.8, seeds: 39, tool: rule-based-clusters)" /transl_table=11 /translation="MTTTSPVTDLYPSRGATEVSTPRQDPVVWGSPGTPGPIAAGELSS FERDGFLAIDQLIGADEVAVYHQELERLVNDPAIRMDERSIVEPKSKEIRSVFEVHRIS EVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPN MRTVSVSIALTENYDTNGGLMIMPGSHRTFLGCAGATPKDNYKKSLQMQDAGTPSDEAL TRMASEYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFSA PVRRPEFIGARDFTPVR" gene complement(5001..5405) /locus_tag="IE325_RS16890" /old_locus_tag="GCM10018780_34150" CDS complement(5001..5405) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) ectoine: ectoine_synt" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009337952.1" /locus_tag="IE325_RS16890" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34150" /product="ectoine synthase" /protein_id="WP_190070722.1" /sec_met_domain="ectoine_synt (E-value: 7.8e-55, bitscore: 179.1, seeds: 10, tool: rule-based-clusters)" /transl_table=11 /translation="MIVRSFKDIEGTDRHVKSASGTWESKRIVLAKEKVGFSLHETILY AGTETSMWYANHIEAVVCVEGEAELTDHETGRTHVITSGTMYLLDGHERHTLRVKKDFR CICVFNPPVTGREDHDENGVYPLLTEPEEV" gene complement(5454..6725) /gene="ectB" /locus_tag="IE325_RS16895" /old_locus_tag="GCM10018780_34160" CDS complement(5454..6725) /EC_number="2.6.1.76" /GO_function="GO:0030170 - pyridoxal phosphate binding [Evidence IEA]" /GO_function="GO:0047307 - diaminobutyrate-pyruvate transaminase activity [Evidence IEA]" /GO_process="GO:0019491 - ectoine biosynthetic process [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 9e-73. Score: 237.1. Matches aSDomain: nrpspksdomains_IE325_RS16895_Aminotran_3.1" /codon_start=1 /gene="ectB" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1013: aminotransferase class-III" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007448159.1" /locus_tag="IE325_RS16895" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34160" /product="diaminobutyrate--2-oxoglutarate transaminase" /protein_id="WP_190070723.1" /sec_met_domain="Aminotran_3 (E-value: 1.1e-76, bitscore: 253.0, seeds: 13, tool: rule-based-clusters)" /transl_table=11 /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRARGSRMYDEDGHEY LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTSAKRAFLQTFQDLVLRPRD LPYKVMFPGPTGTNAVESALKLARKVKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP AWLRALAELCERQDMLLIVDDIQMGCGRTGAFFSFEESGITPDIVTVSKSISGYGLPMS LCLFKPELDIWEPGEHNGTFRGNNPAFVTATAALESYWADGSAMEKQTRARGEQVEQGL IAICEENPADVKEYRGRGLVWGMEFHDKERAGRAAQRAFELGLLVETSGPESEVLKLLP ALTITPDELDEGLRVLARAVTETA" aSDomain complement(5628..6641) /aSDomain="Aminotran_3" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS16895_Aminotran_3.1" /evalue="9.00E-73" /label="IE325_RS16895_Aminotran_3.1" /locus_tag="IE325_RS16895" /protein_end="366" /protein_start="28" /score="237.1" /tool="antismash" /translation="FDRARGSRMYDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE RDGVTHGLDMSTSAKRAFLQTFQDLVLRPRDLPYKVMFPGPTGTNAVESALKLARKVKG REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER LLEDQGSGLNKPAAVIVETVQGEGGINVARPAWLRALAELCERQDMLLIVDDIQMGCGR TGAFFSFEESGITPDIVTVSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV TATAALESYWADGSAMEKQTRARGEQVEQGLIAICEENPADVKEYRGRGLVWGMEFH" gene complement(6757..7263) /gene="ectA" /locus_tag="IE325_RS16900" /old_locus_tag="GCM10018780_34170" CDS complement(6757..7263) /EC_number="2.3.1.178" /GO_function="GO:0033816 - diaminobutyrate acetyltransferase activity [Evidence IEA]" /GO_process="GO:0019491 - ectoine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="ectA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004002246.1" /locus_tag="IE325_RS16900" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34170" /product="diaminobutyrate acetyltransferase" /protein_id="WP_190070724.1" /transl_table=11 /translation="MTAAQADLQIDRPAVADGAALWRIARDSEALDLNSSYSYLLWCRD FAGTSAVARDERGEPVGFITGYVRPDRPHTLLVWQVAVDDAQRGRGIAAALLDGLAARV CGEYGVTGIETTITPGNTASERLFGSFAERHGAALEREVLFPTSLFPDGPHDPEVLYRI GPLSL" misc_feature complement(7296..7309) /note="TFBS match to ArgR, Regulator of arginine biosynthesis genes, confidence: weak, score: 17.46" /tool="antismash" misc_feature complement(7418..7433) /note="TFBS match to CRP, Cyclic AMP receptor protein, confidence: weak, score: 16.03" /tool="antismash" misc_feature 7437..7453 /note="TFBS match to HexR, Glucose-responsive regulator, confidence: weak, score: 17.64" /tool="antismash" misc_feature complement(7456..7470) /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 18.0" /tool="antismash" misc_feature complement(7547..7561) /note="TFBS match to CodY, Regulator of stationary phase and virulence in Gram-positive bacteria, confidence: weak, score: 15.73" /tool="antismash" gene complement(7570..8097) /locus_tag="IE325_RS16905" /old_locus_tag="GCM10018780_34180" CDS complement(7570..8097) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010355555.1" /locus_tag="IE325_RS16905" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34180" /product="DinB family protein" /protein_id="WP_190070725.1" /transl_table=11 /translation="MPTDTTLTLPDGRPIPRLTGPERPMLESWLDFHRATLELKCAGLD DTQVRQESAEPSELTLLGLVQHLAECERNWFQRVAGGLDVPPVYEEETGYALNPERGID EALTTWRREIERGRQVCAGRTLESVGRITDGPMAGVEVGLRWVFIHMIEEYARHNGHAD ILRERIDGVTGA" gene complement(8378..9478) /locus_tag="IE325_RS16910" /old_locus_tag="GCM10018780_34190" CDS complement(8378..9478) /NRPS_PKS="Domain: Aminotran_5 (74-311). E-value: 2e-28. Score: 91.3. Matches aSDomain: nrpspksdomains_IE325_RS16910_Aminotran_5.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_5" /gene_functions="biosynthetic-additional (smcogs) SMCOG1139: aminotransferase class V" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010037833.1" /locus_tag="IE325_RS16910" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_34190" /product="alanine--glyoxylate aminotransferase family protein" /protein_id="WP_190070726.1" /sec_met_domain="Aminotran_5 (E-value: 7e-23, bitscore: 76.1, seeds: 34, tool: rule-based-clusters)" /transl_table=11 /translation="MTHPFLDLPPLTAARFASIEDRVARLLDTRQDVVIMQGEALLPLE GAIRGTAGPGTTALNVITGPYGQTFGNWLRDCGATVIDLAVPFHTAVTADQIRAAFAEH PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCV IGAQKAMGGPAGVSAVSVSERAWARMAANPSAPRRSYLSLLDWKERWIDGGRTALPHAP AQLEMLALEACVERIEGDGLEAVMARHRAAASSTRAGVVALGGGLEPYVHDAREAAPVA TTLRVPAGVVASEVVARVLAAEPGLPLAAGGGGLAREMIRVNHYGVDAGVGVVRGCVAA LGAVLGELGMGVDVGAAVGVVEAGWR" aSDomain complement(8546..9256) /aSDomain="Aminotran_5" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS16910_Aminotran_5.1" /evalue="2.00E-28" /label="IE325_RS16910_Aminotran_5.1" /locus_tag="IE325_RS16910" /protein_end="311" /protein_start="74" /score="91.3" /tool="antismash" /translation="RDCGATVIDLAVPFHTAVTADQIRAAFAEHPEIDFVSLVHAEAAT GNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVSA VSVSERAWARMAANPSAPRRSYLSLLDWKERWIDGGRTALPHAPAQLEMLALEACVERI EGDGLEAVMARHRAAASSTRAGVVALGGGLEPYVHDAREAAPVATTLRVPAGVVASEVV ARVLAAEPGLPLAAG" misc_feature 9479..9493 /note="TFBS match to CelR, Cellobiose uptake repressor, confidence: weak, score: 22.11" /tool="antismash" misc_feature complement(9909..9924) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 21.89" /tool="antismash" ORIGIN 1 tgcacgcgcg ggcccgggcg acgtactacc ccgacgggct gccgcaggac ggcaccgact 61 ggaccgccgc ctggcaggag gccatcgccc ggccggacgg gcatgtgctg tgcgtggtgg 121 aggaggggcg gatcgtcggg ctggcgtcct tccgtacgcc cgagggtgcc gccgtcgaca 181 cggtcaagct gttccagttc catgtcgacc ccgagcactg gcgccgcggt gtcggtacgg 241 cgctgcacgc ggcctgtctg gaggagtggc gggccgacgg caagcgcacc gccgtgctcg 301 acgtgcatgt ggacaaccgg cgcgcccagg ccttctacgc cggccgggga tggctgcccg 361 accccgagaa cccgcccgcc gagggcgatc accatctgta tctgaggttc tccgtgaccg 421 gggaatgaag cccgctgctt gaacgttcac ccactcggcg gagggtgtct ccgtatccgt 481 tcgagctgga gagagccgaa gacatgcgcg tcgagatctg gagcgacatc gcctgcccct 541 ggtgctatgt gggcaaggcc cgcttcgaga aggcgctgga ggccttcccg caccgcgacc 601 aggtcgaggt ggtgcaccgt tccttcgaac tggaccccgg gcgcgccaag ggtgacatcc 661 agcccgtgat caccatgctc acgaagaagt acggcatgag cgccgcgcag gcccaggccg 721 gtgaggagaa cctcggcgcg caggccgccg cggaggggct cgcgtaccgc acccagggcc 781 gcgaccacgg caacaccttc gacatgcacc ggctgctgca cctcgccaag gagcagggcc 841 ggcaggacgc gctgatccag gccctgtaca aggcgaactt cgccgaggag cggtccctgt 901 tctccgaggg cgacgagcgg ctcgtggagc tggccgtggc cgccgggctc gacgccgacg 961 acgcccgcaa ggtcctcgcc gaccccgacg cctacgccga cgacgtccga gccgacgagc 1021 gtgaggccgc ccagctcggg gccaacggcg tgcccttctt cgtcctcgac cgcaagtacg 1081 gcgtctccgg cgcccagccc gcagaggtct tcgagcaggc cctgacacag gcctggggcg 1141 agcggtcgcc gcttcagctc atcgaccagg gtgacgcgga cgcgtgcggc cccgacgggt 1201 gcgcggtgcc gcagaactaa aagcgcaggt gacggcggat ctataaggac tgcttggcga 1261 aaccacgcag aaatagtcaa tggactatca gttctcccgg gcccagagtg gagccatgga 1321 gaccttcgag agcctcgtcc gtaccgagtt cgcgccgaag aacacctacc tgaacacggc 1381 cagtaccggc ctggtaccgg cccgcaccgt cgccgccatg cggaccgccg tggaggccgc 1441 ggccgtcgga cggccgaccg acatgttcgc cgacgtagag gcgagccgcg cctccttcgc 1501 gcggctcgtc ggcgtgcccg ggcaccgggt ggcggccggg gcctccgtcg ccgtctacag 1561 cggcctgatc gccgcctccc tcccgtcggg cgccgaagtc ctcaccgccg agggcgactt 1621 cagctccgtc gtgaacccct tccacgtccg ctccgacctc aaggtgcgca ccgtgccgct 1681 ggagcgggtc gccgagtcgg tgcggcccgg caccgccctg gtcgcggtca gcgccgcgca 1741 gtccgccgac ggccgggtcg ccgacctgcc cgcgatccgt gaggcggccc gcgaacacgg 1801 cacacgtacg tacatcgacg cgtcccaggc caccggatgg ctggacttcg acgcggacgc 1861 ctacgactac tccgcctccg tcgccttcaa gtggctcgtc tgcccacggg gcgtggcctt 1921 cctggtcgtc ccggaggacc tcggcggact caccccgctc ttcgccggct gggtcgcggg 1981 ggaacacccc tgggacgcct gctacggccc catcgacgaa ctcgccgact ccgcacggcg 2041 gttcgacgag agccccgccc tcttctccta cgccggcgcc cgccgctccc tcgaactgct 2101 ggaggaactg ggcgtggacg ccgtacgcgc ccatgacctc gccctcgccg accgcttccg 2161 cgcgggcctc gcctccctcg gccacgagcc cgtcccgtcg cccggctcgc cgatcgtctc 2221 cgtgcccgga ctcggccacc gccaggccgg gctgagcagc gccggagtcg aggtctccga 2281 ccgcgcgggc aacctccgcg cggccttcca cctctacaac acgcccgccg acgtcgaccg 2341 cctcctcgac gtcctctccg cctgaaccga cccgaaccga cccgaaccac tggcgcggga 2401 ccagccggga cgctaggaag ggcacgtgga gtccacgggt gtcacctccg caccgccgcc 2461 tgccgacgcg gaggtgcacc ggcggctggt gtacggcgac gagtccgcgc tggccgaggt 2521 gtacacggcg tacggcgggc tggtgcggcg ggtcgccgtg cgtgtcaccc gctccccggt 2581 cgccgccgag gacgtggcgc aggaggtctt cgcccacctg tggagccggc cgtacacctt 2641 cgacgcgcgc cgcggctcgc tgcgcacctg gctgtccgtg ctcgcccacc ggcgggccgt 2701 ggactgggtg cgcagcgagg ccaggcaccg caaggacgcc ggcgccgacg actcggcgct 2761 ccaggccatc cccgacgccg gccccggccc cgacgagacg gtcgtggacc gcgaacgctc 2821 cctcctcctg cactccgccc tcgccgaact cccgcagcca cagcgcgagg tcgtgcacct 2881 cgcctacttc gccggccgca cctaccggca ggccgcagtg gaactgggca taccggaggg 2941 caccgccaag acccggctgc gcagcgccct gcgctccttg gcggaaactt tggccgaccc 3001 gccggacccg gcgctcgaaa ggggcgcatg atggcgagag gggtacccgt agggaacggg 3061 cacggagagg aggcgcgcga tgaccgacga cgagcacgaa gccgtacgtg acctgctggc 3121 cgcgtgggcc ttcggcgccc tcgacccggc cgaggaggag accctggccc cgcacctggc 3181 cgagtgcgag agctgcgcgg cccaggcggc acggctgcgg gagacggtac gcctgctgga 3241 cgggccggag ccgagcgctc ccgccgggcg gaacaacggc gcgctctccc tcgccctgcg 3301 cgcccgcccc accggccctc gcgtcgccgc gcacgccgcc ccctacgccg ccgcggtcgc 3361 cgggctcaag gcactgctgc ccgagctgga aggccgctgg accacgccgg tcgtgcacga 3421 ctgggacgcg cacgccaccg tcgcccacct cctcgccgcc gacgagcacc tggctggcga 3481 gctcggcgtc gacgcgcgtg tgccgccctc gcggatcgag gagggcacgc actgggagga 3541 cgcctggaac cgccgcagcg ccgatgtcat cgcccatgag cacggccgta ctcccgagga 3601 gaccgtggcc gactgggccg cgcaggccga cgcgctgctc gccaccgctc aggcccacga 3661 tccggaactc gccgcgcggg ccgtgacgct gatggggatg cggctgcccg tcgccgacca 3721 cttcctggtg cgcggcttcg agacctggat ccacaccgac gacctcggcc gcgccctggg 3781 cctcgccgtc ccgccgccac cgccggagca cctggagcgg ctggtccgcc tcgccgtgcg 3841 cgtcctcgga ctggccctcg gacccaccgc gcccccggtg ctgttctcgg tcaccgggga 3901 cgaggaatgg gtgctgggct ccgcggacga gcccgtacag gccgaactca cccttgatcc 3961 gtacgacttc tgcctgctgg tcggcggacg gtacgccccg gagacggtgc ccaggggaca 4021 gaacggcgac gcggccgccg tacggaacgt actggagcgg gccgcgtcgc tgtcctggct 4081 ctgaccggtt acctcgttac ctcaccgggg tgaagtcccg ggcgccgatg aactccggcc 4141 gccgtaccgg agccgagaag ggctccacgg ccgtgttctc cacgctgttg aacacgatga 4201 acacattgct gcgcgggaac ggcgtgatgt tgtcgccgga gccgtgcatg cagttgcagt 4261 cgaaccaggt cgccgaaccg gccttgcccg tgaagagctt gatgccgtac tcggaggcca 4321 tccgcgtcag cgcctcgtcg gacggcgtgc ccgcgtcctg catctgcagg gacttcttgt 4381 agttgtcctt cggcgtggct cccgcgcacc cgaggaaggt gcggtgcgag ccgggcatga 4441 tcatcagccc gccgttggtg tcgtagttct cggtcagcgc gatcgagacg gacaccgtcc 4501 gcatgttcgg cagaccgtcc tcggcgtgcc aggtctcgaa gtccgagtgc cagtagaagc 4561 cgctcgcccc gaagcccggc ttgacgttga tccgcgactg gtggacgtac acgtccgagc 4621 cgaggatctg ccgggcccgg ccgacgaccc gctcgtcgcg cacgagcttc gcgaacacct 4681 cgctgatgcg gtgcacctcg aagacggagc ggatctcctt ggacttcggc tcgacgatgg 4741 agcgttcgtc catacggatc gccgggtcgt tgacgaggcg ctccagctcc tggtggtaga 4801 ccgcgacctc gtcggcgccg atcagctggt cgatggcgag gaagccgtca cgctcgaagg 4861 acgacagttc accggccgcg atcgggcccg gtgtgccggg ggagccccag acgacggggt 4921 cctggcgcgg ggtcgacacc tcggtggcgc cgcggctggg gtagagatcg gtgacgggag 4981 acgttgtcgt catggggttc tcacacctcc tcgggctcgg tgagcagcgg gtacacgccg 5041 ttctcgtcgt ggtcctcccg gccggtcacg ggcgggttga agacacagat gcagcggaag 5101 tccttcttga cccgcagcgt gtgcctctcg tgcccgtcca ggaggtacat ggtcccggac 5161 gtgatcacat gcgtccgccc ggtctcgtgg tcggtcagct cggcctcgcc ctcgacgcag 5221 acgacggcct cgatgtggtt cgcgtaccac atcgacgtct ccgtacccgc gtacaggatc 5281 gtctcgtgca gggagaagcc gaccttctcc ttggcgagga cgatgcgctt gctctcccag 5341 gtgccggacg ccgatttcac atggcggtcg gtgccttcga tgtccttgaa cgaacggacg 5401 atcacggtgc tgcgatgcct cctaggtggg gttttctcgg tacgcgaccg cgctcaggcg 5461 gtctcggtga cggcccgggc gaggacgcgg agcccttcgt ccagctcgtc gggggtgatg 5521 gtcagggcgg ggagcagctt gaggacctcg ctctccgggc cggacgtctc caccaggagc 5581 ccgagctcga aggcgcgctg cgcggcgcgc ccggcccgct ccttgtcgtg gaactccatg 5641 ccccacacca ggccgcggcc ccggtactcc ttgacgtcgg cggggttctc ctcgcagatg 5701 gcgatcagcc cctgctcgac ctgctcgccg cgcgcccggg tctgcttctc catcgccgag 5761 ccgtcggccc agtacgactc cagggcggcg gtggcggtga cgaaggcggg gttgttgccg 5821 cggaaggtgc cgttgtgctc gcccggctcc cagatgtcca gctcgggctt gaacaggcac 5881 agcgacatgg gcagtccgta gccgctgatg gacttggaga cggtgacgat gtccggggtg 5941 atgcccgact cctcgaagga gaagaaggcc cctgtccgcc cgcaccccat ctggatgtcg 6001 tccacgatga gcagcatgtc ctgccgctcg cacagctcgg cgagcgcacg cagccacgcg 6061 ggacgcgcga cgttgatgcc gccctcgccc tgcacggtct ccacgatcac ggcggccggc 6121 ttgttgagcc cggacccctg gtcctccagg agccgctcga accacaggaa gtccgggacg 6181 gtgccgtcga agtagttgtc gaacggcatc ggcgtgccgt gcaccagcgg gatgccggcg 6241 ccggcccgct tgaaggcgtt gccggtgacg gcgagcgagc ccagcgacat cccgtggaag 6301 gcgttggtga acgacacgat ggcctcgcgc cccttcacct tccgggccag cttgagcgcc 6361 gactcgacgg cgttggtgcc cgtcgggccc gggaacatga ccttgtacgg caggtcgcgc 6421 ggccgcagca ccaggtcctg gaaggtctgc aggaaggccc gcttggcgct ggtcgacatg 6481 tcgagcccgt gcgtgacgcc gtcacgctcc aggtagtcga tcaacgcccg tttcaggacc 6541 gggttgttgt gcccgtagtt cagcgagccc gcgccggcga agaagtccag gtactcgtgg 6601 ccgtcctcgt cgtacatacg gctgccccga gcacggtcga agacggtggg ccagccgcgg 6661 cagtagctgc gcacctcgga ctccagggtc tcgaagacgc tgaggtcggg ctgggtgatg 6721 gtcacgacga atcgctcctc gttgcgtggg gggaggtcag agggagaggg gaccgatgcg 6781 gtacaggact tcggggtcgt gcgggccgtc cgggaacagg ctggtgggga acagcacctc 6841 gcgctccagg gcggcgccgt gccgctccgc gaaggagccg aacaggcgct cggaggcggt 6901 gttgccgggc gtgatggtgg tctcgatgcc ggtgacgccg tactcgccgc agacccgcgc 6961 ggcgagcccg tcgagcagtg cggcggcgat gccgcggccg cgctgggcgt cgtcgacggc 7021 gacctgccag acgagcaggg tgtgcgggcg gtccgggcgt acgtacccgg tgatgaagcc 7081 gaccggctcc ccgcgctcgt cacgagcgac ggccgacgtg ccggcgaagt cgcggcacca 7141 cagcagatag ctgtacgacg agttgaggtc gagggcttcg gagtctctgg ctatccgcca 7201 cagcgcggcc ccgtcggcca ccgccggacg gtcgatttgc aggtctgctt gtgcggcagt 7261 catgcgaatt gaatttaccg agggaaaatt gaaattgcat ggccgtacgg ggttacgcgt 7321 ggtggcgcga tgtgttatca cgcgggcgtg aggagcactg cggtgacctg gtggtatgca 7381 cctttcgccc cggtaatttc acgcaaatcg gacgggatgt ggaacgcatc acagggttgt 7441 aactctcctg gaacctgtcc gaatcagtcc gataggtgtt cgcggaattt ttgcgtttag 7501 gttccgggaa agcgggcaga agacgatggg aagctgccct cgaaaagaat ttctggaata 7561 accctgaatt caggctccgg taacaccgtc gatacgctct cgcagaatgt cggcgtggcc 7621 gttgtgccgg gcgtactcct cgatcatatg aatgaacacc cagcgcagac cgacctcgac 7681 cccggccatc ggtccgtccg tgatccgacc cacactctcc agcgtccggc ccgcgcacac 7741 ctggcgccct cgctcgatct cccgccgcca ggtcgtgagc gcctcgtcga tgccgcgctc 7801 ggggttgagc gcgtatccgg tctcctcctc gtacaccggc ggcacgtcga gcccgcccgc 7861 cacccgctgg aaccagttcc gctcacactc cgcgaggtgc tgcaccaggc cgagcagggt 7921 cagctccgac ggctcggcgg attcttggcg cacctgtgtg tcgtccaggc ccgcgcactt 7981 cagctccagg gtggcgcggt ggaagtccag ccagctttcg agcatggggc gctcggggcc 8041 ggtgaggcgg gggatggggc ggccgtcggg gagggtgagg gtggtgtcgg tgggcatgtg 8101 gggagcatgg cagggcgggg ggttgtgggc gaggtggttc ttggtggagg ggccttttct 8161 cgccccgccg cccctacccg tcccatcctg gggctccgcc ccagaccccg ctcctcaaac 8221 gccggagggg ctgagtttca gcgaccgccg gaggggctgg gtttttcagc ccgtccggcg 8281 tttgaggacg aggcccgttc agggccgaag cgggggtccg ggggcggcag cccccgggga 8341 cgggacgggt aggggcggcg ggggcgaaaa aaccccgcta ccgccaaccc gcctccacca 8401 cccccaccgc cgcccccaca tccacaccca tccccagttc ccccaacacg gcccccaacg 8461 ccgccacaca cccccgcacg acccccaccc ccgcatccac cccatagtga ttgacccgga 8521 tcatctccct ggccaacccc ccacccccgg cagccagcgg caaccccggc tcggcagcca 8581 acacccgcgc caccacctcc gacgccacca cccccgccgg cacccgcagc gtcgtagcga 8641 ccggagccgc ctcgcgggca tcgtggacgt acggctcaag acccccgccc agcgccacca 8701 ccccggcccg cgtcgacgag gccgccgcac gatggcgggc catcaccgcc tccagcccgt 8761 ccccctcgat ccgctccacg cacgcctcca gcgccagcat ctccagctgc gcgggcgcat 8821 gcggcagcgc cgtgcgcccg ccgtcgatcc accgctcctt ccagtccagc aaggacagat 8881 acgacctccg cggcgccgag gggttcgccg ccatccgcgc ccacgcccgc tcgctcacgg 8941 acaccgccga caccccggca ggcccgccca tcgccttctg cgccccgatc acacacaggt 9001 ccacacccca cgcgtccggc agcaccggct cggcgccgat cgacgccacc gcgtccaggt 9061 agaacagcgc cccgtgcgcc cgcacgacct cgccgatctc cgcgacggga ttggtgttgc 9121 cggtcgccgc ctccgcgtgc accagcgaga cgaagtcgat ctccgggtgc tcggcgaagg 9181 cggcacggat ctggtccgcc gtcaccgccg tatggaaggg caccgccaga tcgatcaccg 9241 tcgcgccgca gtcccgcagc cagttcccga aggtctgccc gtaaggaccg gtgatcacgt 9301 tcagcgcggt cgtaccgggc ccggccgtcc cccggatcgc cccctccagc ggcagcagcg 9361 cctcaccctg catgatcacg acgtcctgcc gggtgtccag cagccgcgcc acccggtcct 9421 cgatcgaggc gaagcgcgcg gcggtcagcg gaggcagatc gaggaacggg tgggtcatgg 9481 agagcgctcg cattcttcgt agaagttctg ggcggtggag gtctactccg ccgatcttag 9541 gtagaacggc tccacagcca tcggtttggt ttgaggtact caaacccttc cttataatcg 9601 gaacccacag ttccctgaca ggaggctccc cgtgaagacg accctcgggc gccggacccg 9661 cgttctggcc gccaccaccg cgacggccgg gctggtgctc gtggccggct gctcctccga 9721 cgacagcggt ggcggtggca cgaagacggc cgccggcggt gtcgagctcg tcaaggcggg 9781 ccagctcacc acctgcaccc acctgcccta cccgcccttc cagtcggaga tcgacggcaa 9841 ggtgcagggc ttcgacgtct cgctgatcga cctggtcgcg gacgacctgg gagtgaagca 9901 ggtcatcgtc gaccagccct tcgagaactt caagaccggc ggctctctca acgccggcag 9961 ctgcgacctc gccgccgccg gcatgaccat caccgaggag cgcaagaaga acgtcgactt 10021 ctccgacccg tacttcgacg ccacccaggc cgtcctggtc gacaagaaga gcggcatcac 10081 gtccttcgcc ggtctcaagg gcaagaaggt cggcgcccag gcgcagacca ccggtgagga 10141 ctacgccaag agcaagggcc tggacccggt gtccttcgag tcctccgacg ccgtcatcaa 10201 cggcctgcgc tccggccagg tcgaggccgt cgtcatcgac tacccggtcg tccagggctg 10261 gctgaaggac aaggccaacg ccgacgcctt caaggtcgcc gagcaggtca acaccggcga 10321 gcagtacggc ttcacggtga agaagggcaa caccaagctc ctcgcggcca tcaacaaggc 10381 cctcacggac gcgaaggccg acggt //