LOCUS       NZ_BNBM01000004        20165 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000004
VERSION     NZ_BNBM01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 659677)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 127370
            Orig. end                         :: 147535
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20165
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20165
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20165
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10165](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10165)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            77..304
                     /locus_tag="IE325_RS12555"
                     /old_locus_tag="GCM10018780_25320"
     CDS             77..304
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020684277.1"
                     /locus_tag="IE325_RS12555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25320"
                     /product="hypothetical protein"
                     /protein_id="WP_229911788.1"
                     /transl_table=11
                     /translation="MRTLLGLDDDTAVMVRQLTRTEPDCPPVETVVAVLPMDGAARRWT
                     LHQLADQITKDDLRAALLNPDPDHHDHPDR"
     gene            complement(428..1162)
                     /locus_tag="IE325_RS12560"
                     /old_locus_tag="GCM10018780_25330"
     CDS             complement(428..1162)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357868.1"
                     /locus_tag="IE325_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25330"
                     /product="family 16 glycosylhydrolase"
                     /protein_id="WP_190069917.1"
                     /transl_table=11
                     /translation="MTSIPRRPSRRRVLGAALAVPPALMLGASAARADSWGAPVTVSSW
                     NKINGRWTANNELETYTPDCVWYEGDTLVIKAYNAGGGVYYSGRVESTALYGYGTYSFT
                     ANMPNGQGLLPAVWAAYLNPWLPEFDAAEIVGQNPNVVHQTSHDVNNAQQQFSKTNTSG
                     WTNAYHTYSFSWFPDHIDFAVDGTITGTTWYRTPAGTGMHFIANIAVGGDWPGNPDSST
                     WATADGARYLKISSITHTPYNP"
     misc_feature    complement(1195..1209)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.19"
                     /tool="antismash"
     misc_feature    1196..1210
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.39"
                     /tool="antismash"
     gene            <1395..>1601
                     /locus_tag="IE325_RS12565"
                     /pseudo=""
     CDS             1395..>1601
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005473397.1"
                     /locus_tag="IE325_RS12565"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="pyridine nucleotide-disulfide oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRRVIVVRSGNCGAQIAADLAYDTQLTWVAQHPPRYLADAIDSP
                     ALFDAAAARCRTLETGRTYTGGVA"
     gene            1790..2125
                     /locus_tag="IE325_RS12570"
                     /old_locus_tag="GCM10018780_25350"
     CDS             1790..2125
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069600.1"
                     /locus_tag="IE325_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25350"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190069918.1"
                     /transl_table=11
                     /translation="MLTVASEVEVLARFGRALADPIRCRLLLALREAPAHPSDLAERLG
                     ISRTRLSNHLACLRDCGLVIGVPVGRRTRYELADPRLAHALDDLRTAVVAVETDRTCTE
                     ADEKGCC"
     gene            2125..2832
                     /locus_tag="IE325_RS12575"
                     /old_locus_tag="GCM10018780_25360"
     CDS             2125..2832
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638991.1"
                     /locus_tag="IE325_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25360"
                     /product="cation transporter"
                     /protein_id="WP_190069919.1"
                     /transl_table=11
                     /translation="MTALSLGPAPARRDQLTRRIRLLVAATITYNVVEAIVAITAGTLA
                     SSTALIGFGLDSVIEVSSAAAVAWQFSAADHAVREAREKTTLRIIAVSFFALAAYVTVD
                     AVRALAGTGEADRSIPGIVLAALSLLVMPFLSAAQRRAGRELGSLSAVADSRQTLLCTY
                     LSAVLLAGLVLNATLGWSWADPVAGLVIAVIALKEGRDAWQGKGCCAAPTAVTAPSAAE
                     ADRCGCRAGCDCC"
     gene            3002..3664
                     /locus_tag="IE325_RS12580"
                     /old_locus_tag="GCM10018780_25370"
     CDS             3002..3664
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997905.1"
                     /locus_tag="IE325_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25370"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_190069920.1"
                     /transl_table=11
                     /translation="MHQHHGDLAATQQEHWQQTYAAHPGMYGAAPSGPAAYAATAFREA
                     GAEVVLELGAGHGRDALHFAREGFRVHATDFSPVGLDQLVDAARAEQLAERISTTVHDV
                     RTPLPLADASIDAVFAHMLLCMALSTDEIHALIDEVRRVLRPGGVFVYTVRHTGDAHYG
                     AGVAHGDDIYEHGGFAVHFFPRRLVDELAAGWDLTEVFAFEEGELPRRLWRVTQIAH"
     gene            complement(3715..4092)
                     /locus_tag="IE325_RS12585"
                     /old_locus_tag="GCM10018780_25380"
     CDS             complement(3715..4092)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659443.1"
                     /locus_tag="IE325_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25380"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190069921.1"
                     /transl_table=11
                     /translation="MSNTKVLPLLESEAPEAVAPCCPPLTERPFTAEEAETAARMFKAL
                     GDPVRLRLFSLVASHEGGEACVCDISDVGVSQPTVSHHLKKLKEAGLLTSERRGTWVYY
                     RVEPSVLAAMGKLLTMAPAAA"
     gene            4349..5728
                     /locus_tag="IE325_RS12590"
                     /old_locus_tag="GCM10018780_25390"
     CDS             4349..5728
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324868.1"
                     /locus_tag="IE325_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25390"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_229911816.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.5e-14, bitscore:
                     47.1, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 6.5e-08, bitscore: 27.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSINSVPTTDQLPVVVIGAGPIGLAAAAHLVERGLEPLVLEAGPS
                     AGTAVRDWAHVRLFSPWAEVTDPAAEKLLAPTGWVRPDGAIYPTGGDWAEQYLQPLADV
                     LGDKVRYGVTVTGVARAGRDRIVDADRDEQPFTVHLQSADGHEERLTARAVIDASGTWA
                     IPSPMGADGLPALGEKTAADRIAYRVPDLKDPAARARYAGRRTAVIGSGASAFTALAYL
                     ADLAKEEPGTHTAWILRRGIGANTFGGGDADQLPARGALGLRAKEAVEAGHASAVTGFR
                     TQAVDRDGDQLVLVAEDGRRLDPVDEVIVLTGFRPDLSFLSEVRLGLDERLQAPTALAP
                     LIDPNVHSCGTVYPHGVGELSHPEQGVYLVGMKSYGRAPTFLAMTGYEQVRSITAALAG
                     DQEAAERVELTLPETGVCGGAGLYDDPDATQSSEGGGCCAAPATLQIGIGAAPITTTGG
                     C"
     gene            5757..6215
                     /locus_tag="IE325_RS12595"
                     /old_locus_tag="GCM10018780_25400"
     CDS             5757..6215
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445803.1"
                     /locus_tag="IE325_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25400"
                     /product="ArsI/CadI family heavy metal resistance
                     metalloenzyme"
                     /protein_id="WP_190069922.1"
                     /transl_table=11
                     /translation="MSRVQLALRVPDLDASIAFYSKLFGTEPAKLRDGYANFAITEPPL
                     KLVLIEGTDGEATRLDHLGVEVETTDAVHAATARLSEAGLATAEENDTTCCYALQDKVW
                     VHGPGQEPWEVYVVKADADTLTKQQGSTCCATPADATVKEPAVAGGCC"
     assembly_gap    6254..6268
                     /estimated_length=15
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <6269..>6447
                     /locus_tag="IE325_RS46055"
                     /pseudo=""
     CDS             6269..>6447
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844281.1"
                     /locus_tag="IE325_RS46055"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRPHAALPALRATEITSWGIVYYASRS"
     gene            complement(6454..7959)
                     /locus_tag="IE325_RS12600"
                     /old_locus_tag="GCM10018780_25410"
     CDS             complement(6454..7959)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015103 - inorganic anion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643667.1"
                     /locus_tag="IE325_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25410"
                     /product="SulP family inorganic anion transporter"
                     /protein_id="WP_190069923.1"
                     /transl_table=11
                     /translation="MSSSALSPAARLRGLRPDWLSDPRVWRTEVLAGLVVALALIPEAI
                     SFSIIAGVDPAIGLFASFTMAVTISIVGGRRAMISAATGAVALVIAPLNREHGLGHLVA
                     AVILAGVFQIVLGALGVAKLMRFVPRSVMVGFVNALAILIFIAQVPEMHDVPWPVYPLI
                     VGGLALMVFFPKVTKVIPAPLVSIVILTVITVAAGIAVPTVGDKGDLPSSLPVPGLPDV
                     PFTLDTLTTIAPYALAMALVGLMESLMTAKLVDDITDTHSSKTRESIGQGIANIVTGFF
                     GGMGGCAMIGQTMINVKVSGARTRLSTFLAGSFLMVLCIVFGPVVSDIPMAALVAVMVM
                     VSFATFDWHSIAPKTLKRMPAGEITVMVITVACVVATDNLAIGVVVGSITAMVVFAKRV
                     AHLANVTAVVDPDGTQVVYSVTGELFFASSNDLVTQFNYATDPDTVVIDLTAAHIWDAS
                     SVAALDAIETKYTQRGKTVEIIGLNQPSAQIHEKLSGELTGSH"
     gene            8376..8780
                     /locus_tag="IE325_RS12605"
                     /old_locus_tag="GCM10018780_25420"
     CDS             8376..8780
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065103.1"
                     /locus_tag="IE325_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25420"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_190069924.1"
                     /transl_table=11
                     /translation="MSSEHMQIGEVAARTELSLRTIRHYEETGLVIPSARSQGGFRLYT
                     ETDVARLMVIRRMKPLGFTLDQMRDLLEVTDRLDAVPPPGGTEREELLERVRHFEQAAV
                     ERVADLRKQLGRAEEFAGTLRERLAPVPTA"
     gene            8989..9909
                     /locus_tag="IE325_RS12610"
                     /old_locus_tag="GCM10018780_25430"
     CDS             8989..9909
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (19-237). E-value: 3.3e-42.
                     Score: 136.6. Matches aSDomain:
                     nrpspksdomains_IE325_RS12610_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005319926.1"
                     /locus_tag="IE325_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25430"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_190069925.1"
                     /sec_met_domain="ADH_N (E-value: 1.3e-08, bitscore: 29.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1e-17, bitscore:
                     59.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAITVQDREAGASGLALVELPHPHAAENDVIVKVHAAGFTPGEL
                     DWPGTWTDRAGRDRTPSVPGHELSGVVTELGYGTTGLTIGQRVYGLADWARNGTLAQYT
                     AVEARNLAPLPADVDHVTAAALPISGLTAWQALFDHAHLRTGQSVLIHGAAGGVGSIAV
                     QLARAAGAQVIGTGRADDRDTALGLGAHAFLDLQAEKLEDIGDVDVVFDVIGGEILERS
                     TALVRPGGTLVTIAEPVTVHPRDGRAVFFVVEPDRVRLSDLAERVRDGRLKPIIGDVRP
                     LTEAVAAFTPDKRTHGKTIIRITED"
     CDS_motif       9019..9051
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS12610_0001"
                     /evalue="8.20E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE325_RS12610"
                     /protein_end="21"
                     /protein_start="10"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="AGASGLALVEL"
     aSDomain        9046..9699
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS12610_PKS_ER.1"
                     /evalue="3.30E-42"
                     /label="IE325_RS12610_PKS_ER.1"
                     /locus_tag="IE325_RS12610"
                     /protein_end="237"
                     /protein_start="19"
                     /score="136.6"
                     /tool="antismash"
                     /translation="ELPHPHAAENDVIVKVHAAGFTPGELDWPGTWTDRAGRDRTPSVP
                     GHELSGVVTELGYGTTGLTIGQRVYGLADWARNGTLAQYTAVEARNLAPLPADVDHVTA
                     AALPISGLTAWQALFDHAHLRTGQSVLIHGAAGGVGSIAVQLARAAGAQVIGTGRADDR
                     DTALGLGAHAFLDLQAEKLEDIGDVDVVFDVIGGEILERSTALVRPGGTLVTIAE"
     CDS_motif       9424..9486
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS12610_0002"
                     /evalue="1.40E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE325_RS12610"
                     /protein_end="166"
                     /protein_start="145"
                     /score="27.0"
                     /tool="antismash"
                     /translation="GQSVLIHGAAGGVGSIAVQLA"
     gene            complement(10001..10165)
                     /locus_tag="IE325_RS12615"
                     /old_locus_tag="GCM10018780_25440"
     CDS             complement(10001..10165)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE325_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018780_25440"
                     /product="hypothetical protein"
                     /protein_id="WP_190069926.1"
                     /sec_met_domain="T1TS (E-value: 1.1e-06, bitscore: 23.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSVQCVSCLDAEKAVPVIGRTGLADYVRVLRAWFRGHYDWCRV
                     TRRYNAPLT"
     gene            complement(10202..11299)
                     /locus_tag="IE325_RS12620"
                     /old_locus_tag="GCM10018780_25450"
     CDS             complement(10202..11299)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IE325_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25450"
                     /product="MFS transporter"
                     /protein_id="WP_190069927.1"
                     /transl_table=11
                     /translation="MRSVAVYALLLALGALDAAGYSLIAPVLPGLAARTGAGATAMGLL
                     VAMFPLGMVAGFAVGGAVVQRSSPARLLLMGLLLVAAGSLGFVFGSDLAAFTVSRLVMG
                     LGSGCLWLGITFATLAAWPGQEYLCMSRIYAAYSAGGLLGPLLGAVHGVRGPFVAYLAL
                     VVLAVVPVATLRLPSAVGAFTTDRHAVRSPGFLAAAASIAFAVMALGTLEGVLPLHFGT
                     KLRQSQIGVLYAATSVLVVVAGAVAARWQPRKVMLGSTVPVAVGFAVAGASSAVPLWIA
                     ALAVAGVGIGLANTGATGILLDAVPAQRIVTAMVLWSQIGILGYLVAPLLGGPTADAFG
                     YGAVAAVVALTAAALTVMLARPGRA"
     gene            complement(11335..11676)
                     /locus_tag="IE325_RS12625"
                     /old_locus_tag="GCM10018780_25460"
     CDS             complement(11335..11676)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018382014.1"
                     /locus_tag="IE325_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25460"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_229911789.1"
                     /transl_table=11
                     /translation="MERSEAEQYASWFKALADATRIQIVTLLARSSEPLAVGQIVEAVA
                     VGQSTVSHHLKGLAEVGFVLVEREGSFSRYRLNEECVDAFPSAADVVMGRPAPARSGSG
                     PVRGRWRSG"
     misc_feature    complement(11662..11676)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            11708..>11896
                     /locus_tag="IE325_RS12630"
                     /old_locus_tag="GCM10018780_25470"
                     /pseudo=""
     CDS             11708..>11896
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000187.1"
                     /locus_tag="IE325_RS12630"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25470"
                     /product="ArsR/SmtB family transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTELVATPLHPSTTAEEAERTARMFKALGDPVRLRLFSAVASHEG
                     GEACVCDISDVGVSQPTV"
     gene            complement(12165..13226)
                     /locus_tag="IE325_RS12635"
                     /old_locus_tag="GCM10018780_25480"
     CDS             complement(12165..13226)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445852.1"
                     /locus_tag="IE325_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25480"
                     /product="ArsO family NAD(P)H-dependent flavin-containing
                     monooxygenase"
                     /protein_id="WP_190069929.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.3e-16, bitscore:
                     54.1, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 4.7e-09, bitscore: 31.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTTQVVVIGGGQAGLAAGYHLRRRGLTFVILDSQADPGGAWQH
                     TWDSLHLFSPASYSSLPGWLMPPQSGEEYPDAAHVVTYLRDYEKRYGLDVRRPVRVLGV
                     HRDASQLLRVETDSGTWHTQAVISATGTWQRPFLPAVPGRESFGGRQLHTVEYRRPQDF
                     AGRRVIVVGGGNSGAQIAADLAYNTHLTWVTQRPPRFLADDIDGRVLFDVASARRRALD
                     EGRTDTGGVASLGDIVAVPPVRQARERGLLKTVPMFTRLVPGGVEWADGTRAEADAIIW
                     CTGFRPALSHLAPLQLRGRRGHIGTAGTRAVDEPRLHLLGYGDWTGPASATLIGVGRPA
                     RDAAREIAALLGV"
     gene            complement(13223..14005)
                     /locus_tag="IE325_RS12640"
                     /old_locus_tag="GCM10018780_25490"
     CDS             complement(13223..14005)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659441.1"
                     /locus_tag="IE325_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25490"
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_190069930.1"
                     /transl_table=11
                     /translation="MTATHESAAQSARADVSPQPAPGATPPRAPLFARAAAELVGTAAL
                     VAVVVGSGIQATELTQDVGVQLLANSLATVFGLGVLITLLGPVSGAHFNPAVTLAEWWT
                     ARRGGAGVTLREAAVYVPAQIVGAIAGAVLADAMFGEPLVKWSTHDRSAGHLLLGEVVA
                     TAGLILLIFGLARTDRLRFAPVAVASYIGAAYWFTSSTSFANPAVTIGRAFTDTFAGIA
                     PGSLAGFIGMQIVGAVVGLALVALIFAPARTAAEQPAV"
     gene            complement(14043..14351)
                     /locus_tag="IE325_RS12645"
                     /old_locus_tag="GCM10018780_25500"
     CDS             complement(14043..14351)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975238.1"
                     /locus_tag="IE325_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25500"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190069931.1"
                     /transl_table=11
                     /translation="MLTSVDTDLIRVLADPLRLRIVTLLAKETLCTTHLVEETGAKQTN
                     LSNHLRVLREAGVVETEPCGRFTYYKLRPDVIASLAGQFADLAEAARAAADNKRSCP"
     misc_feature    14355..14367
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            14445..14858
                     /locus_tag="IE325_RS12650"
                     /old_locus_tag="GCM10018780_25510"
     CDS             14445..14858
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325493.1"
                     /locus_tag="IE325_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25510"
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_190069932.1"
                     /transl_table=11
                     /translation="MSDKPSVLFVCVHNAGRSQMAAAWLTHLAGDRVEVRSAGSNPGAN
                     VNPAAVEAMAEVGIDISAEVPKMLTVDAVKESDVCITMGCGDTCPVFPGKRYLDWQLDD
                     PAGQGVDAVRPIRDEIKVLVEGLIEEIAPEPQA"
     gene            14855..15838
                     /gene="trxB"
                     /locus_tag="IE325_RS12655"
                     /old_locus_tag="GCM10018780_25520"
     CDS             14855..15838
                     /EC_number="1.8.1.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trxB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125994.1"
                     /locus_tag="IE325_RS12655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25520"
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="WP_190069933.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.3e-47, bitscore:
                     155.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTATDVRNVIVIGSGPAGYTAALYTARASLKPLVFEGAVTAGGA
                     LVQTTEVENFPGFPGGIMGLELMDNMRAQAERFGAELVPDDIVAVDLTGEVKTVTDSAG
                     TVHRAKAVIVATGSQHRKLDLPGEDALSGRGVSYCATCDGFFFREHDIVVVGGGDTAME
                     EATFLSRFARSVTIVHRRDTLRASRTMQDRAFADPKISFAWNREVAEIHEDGGKLAGLT
                     LRDTVTGDTSHLPATGLFVAIGHDPRTDLVTGQLDLDEEGYLKVASPSTRTNIPGVFGA
                     GDVVDHTYRQAITAAGSGCAAALDAERYLAALSDTDAAGEPAVAAV"
     gene            15859..16170
                     /gene="trxA"
                     /locus_tag="IE325_RS12660"
     CDS             15859..16170
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="trxA"
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143578.1"
                     /locus_tag="IE325_RS12660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin"
                     /protein_id="WP_190070321.1"
                     /transl_table=11
                     /translation="MALKNVTEDSFEQDVLNSDKPVLVDFWAAWCGPCREIAPSLEAIA
                     AEHGDKIEIVKLNIDENPAIAARDGVMSIPTPHLYKGGEVVQTIVGAKAEAALERELA"
     misc_feature    16236..16253
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            16243..17406
                     /locus_tag="IE325_RS12665"
                     /old_locus_tag="GCM10018780_25540"
     CDS             16243..17406
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.5"
                     /locus_tag="IE325_RS12665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25540"
                     /product="FAD/NAD(P)-binding oxidoreductase"
                     /protein_id="WP_229911790.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.9e-44, bitscore:
                     146.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGKRIVAIGGSDAGISAALRARELDPDSEVTVVVADAYPKFSIC
                     GIPYHVSGEVGHWSDLAHRTLAELKATGILVHTDTLATGIDVTGKQLTLRDAEGRTDQL
                     PYDALIVGTGAVSARPPIAGLSGSDALGPQDGVHLLHSMGDTFAFMQSLAERRPKSVVV
                     IGAGYIGLEMAEALTTRGLKVTQIEALPEVLPTVDVELGALVHDELAAHGVEVITGTQV
                     SAITRAPAGDLLHVHAAGPGGAAFTRGTELVLVIVGVRLGAKGAIDVDEYMRTSLPDVY
                     AAGDCAVTHHRLLGKTWLPSRPPLTSRAASRARMHLAVPVGSPAASAPRSSRSSIWSPP
                     APACATPRRNPREEAGLRPPPPAVPWSALTPASAEPSLKGLDSTAYL"
     gene            complement(18041..18931)
                     /locus_tag="IE325_RS12670"
                     /old_locus_tag="GCM10018780_25560"
     CDS             complement(18041..18931)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175790.1"
                     /locus_tag="IE325_RS12670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25560"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_190069934.1"
                     /transl_table=11
                     /translation="MDPHLLRTFVAVARCASFSRAARELGYTQSAVSQHIAALESDLGA
                     VLLHRRPVTPTGVGTRLLEHAGPLLLRLDAARADIARLTVAPAARIVIGVSPLAMTRQF
                     TGTLAEVRRSQPRLEVTVRVLGREALTRDVATAALDLGLVDGMAAPNDPLHLPDAGLLR
                     ATAVAEHPLAVALPAQHPLADRAGLRLADLADARWIDAPDTAIPLRQLRTASGADGHRA
                     SLRYEGGDVRGLITLIAAGLGLALLPRPVIKGAPGISAVPVSAPRLVHRVEALHSDTLD
                     GPPALLTAALVAAAG"
     gene            19008..19751
                     /locus_tag="IE325_RS12675"
                     /old_locus_tag="GCM10018780_25570"
     CDS             19008..19751
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071449.1"
                     /locus_tag="IE325_RS12675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_25570"
                     /product="hypothetical protein"
                     /protein_id="WP_190069935.1"
                     /transl_table=11
                     /translation="MPELETFPTARVALVGDRSPSVRAHTRIPALLEALAQHDQLVLDA
                     YWIPTEDAESAGALNGFDAIWLVPGSPYRSEAGALAAPRSAREQGIPFLGTCGGFQHAV
                     LEFARDVCGLTGVNHAENRPEAEDLLIVPLACSLVGHEGAVKVEAGSLAERVLGAERTV
                     ERYHCSYGTSPAYLDVLRAHGLRFSGVDEAGDVRVAELPGHPFFLATLFQPELTGDGTR
                     PHPIIRALASAAVERATKRSARAFA"
     misc_feature    20054..20068
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.79"
                     /tool="antismash"
ORIGIN
        1 gagaaccgcc atgccgcttg gagcgcgccc cggacaccca gggccgagcc cgcaactgcg
       61 tgagctgagg gacaccgtgc gcaccctgct cggcctcgac gacgacaccg ccgtcatggt
      121 ccgccagctc acccgcaccg agccggactg cccgccggtc gagaccgtcg tcgctgtact
      181 gccgatggac ggcgcggctc gccgctggac tctgcaccaa cttgccgacc agatcaccaa
      241 ggacgacctg cgggccgccc tgctcaaccc cgacccggac caccacgatc acccggaccg
      301 ctagcagccc gactcgaggt caagcgcgag gacgtggaga acgagaccat cgagaccgag
      361 accaggcacc agctcgacac cacggtcacc cccggacttg ccggtcaggg acgtggccca
      421 gttcatctca tgggttgtac ggcgtgtgcg tgatggagga aatcttgagg tagcgggcgc
      481 cgtcggcggt ggcccaggtg gatgagtccg ggttgccggg ccagtcaccg cccactgcga
      541 tgttggcgat gaagtgcatg cccgttccgg ccggagtgcg gtaccacgta gtacctgtga
      601 tggttccgtc cacggcgaag tcgatgtgat ccgggaacca gctgaacgag tacgtgtgat
      661 acgcattcgt ccagccggag gtgttcgtct tcgagaactg ttgctgggcg ttgttgacgt
      721 catgtgacgt ctggtggacg acgttcgggt tctgccccac gatttccgcg gcgtcgaact
      781 ccggcagcca cggattcagg tacgccgccc ataccgcggg gagcaggccc tgtccgttgg
      841 gcatgttcgc agtgaagctg taggtgccgt acccgtacag tgccgtcgac tccacgcggc
      901 ccgagtaata gaccccgccc ccggcgttgt acgccttgat caccaacgtg tcgccctcgt
      961 accagacgca gtccggcgtg tacgtctcca gctcgttgtt ggcagtccac cttccgttga
     1021 tcttgttcca ggagctgacc gtcaccggcg caccccagga atcggcacgt gccgccgacg
     1081 caccgagcat cagtgcgggc ggcacggcca gggcggcgcc aagtacgcgt ctgcggctcg
     1141 gcctacgagg tatggaggtc atcacggctc cattgcttgg acgaccgaag gggcgtggga
     1201 gcgatcccac gccccacttg tcgccggact gtaggagtcc gttcgtccat tgacaagacg
     1261 cgtcgcacag atcggtgcct gcctttggaa gttgaacgag caatgccgaa tcgaacagcc
     1321 cgagaaatca agggcccgca gggcgtttgc gtgactggcc gcgaccagtg agggattctc
     1381 ctcggtcggc ccagtccggc cgccgggtga tcgtggtgcg aagcggcaac tgcggcgctc
     1441 agatcgccgc cgatctcgcc tacgacaccc agctgacctg ggtcgcccag cacccgcccc
     1501 gctacctggc cgacgccatc gacagccccg ccctcttcga cgcggccgcc gcccgctgcc
     1561 gcaccttgga gacaggccgc acctacaccg gcggcgtcgc cccacgtagc cgacggcccg
     1621 ggcggtgtgc gtgccgacgc tcggcggcgg ctgtgaggcg ctggaagccg acccagcact
     1681 tcaactccca ccgagcccag ctcaccctgg gcccgggcgt gacggcacct ccatcaaagc
     1741 gaacgagtac acggtttcct gaattcagga tttcttgtac ggtcaagacg tgctgactgt
     1801 cgcttccgag gtcgaggtgc tcgcgcgctt cggccgtgcc ctcgccgatc cgatccgctg
     1861 ccgtctgctg ctggccctgc gtgaggcccc ggcgcatccg tccgacctgg ccgagcggct
     1921 gggcatctcg cgcacccggc tctccaacca cctggcgtgc ctgcgcgact gcggactggt
     1981 catcggggtt cccgtcgggc ggcgtacccg ctacgaactc gccgacccgc gtctggcgca
     2041 cgccctggac gacctgcgca ccgccgtcgt cgcggtcgag acggaccgca cctgcaccga
     2101 ggccgacgag aagggctgct gctgatgacc gcgctctccc tggggcccgc gccggcccgg
     2161 cgcgatcaac tcacccgccg tatacgcctc ctggtcgcgg cgacgatcac atacaacgtg
     2221 gtcgaagcga tcgtggcgat caccgcaggc acactggcgt cctccacggc actgatcggc
     2281 ttcggcctcg actccgtcat cgaggtctcc tcggcggcgg ccgtggcctg gcagttctcc
     2341 gcggccgacc acgccgtgcg ggaggcccgg gagaagacca cactgcggat catcgcggtc
     2401 tcgttcttcg cgctcgccgc ctacgtcacc gtcgatgccg tacgcgccct ggccggtacc
     2461 ggtgaggccg accgatcgat ccccggcatc gtgctcgccg cgctctccct gctggtcatg
     2521 ccgttcctgt ccgcggctca gcgccgcgcc ggacgggagc tcggctcgct gtccgccgtc
     2581 gcggactcac ggcagacgct gctgtgcacc tatctgtccg ccgtcctcct ggcgggactg
     2641 gtcctcaacg ccaccctcgg gtggtcctgg gccgaccccg tcgccggcct ggtcatcgcg
     2701 gtcatcgccc tcaaggaggg ccgtgacgcc tggcagggca agggatgctg cgccgcgccc
     2761 accgccgtaa cagcaccctc ggccgccgag gcggaccggt gcggctgccg cgcgggctgc
     2821 gactgctgct gaaccccgca tggccaccga cgacggaaag ccgcctgccg gtcccccacc
     2881 tggcacttgg cctccgccac gcacacccgc ctccctcccg cggcgcagcg acctccccgt
     2941 ggaaggatca gccgggacag accgcccgcg ggcgggagac tcaccggcgc ccggagaccc
     3001 gatgcaccag caccacggcg atctcgccgc cacccagcag gagcactggc agcagaccta
     3061 cgccgcccac cccgggatgt acggcgcggc accctccggc cccgcggcat acgccgccac
     3121 cgccttccgc gaggccggtg ccgaggtcgt gctggagctg ggtgccgggc acggccgcga
     3181 cgccctgcac ttcgcccgcg agggcttccg cgtccatgcc accgacttca gcccggtcgg
     3241 cctggaccag ctcgtcgacg ccgcccgcgc cgagcaactc gccgagcgga tcagcaccac
     3301 ggtgcacgac gtccgcaccc cactgccgct ggccgacgcc tccatcgacg cggtcttcgc
     3361 gcacatgctg ctgtgcatgg cactgtccac cgacgagatc cacgccctga tcgacgaggt
     3421 ccgacgggta ctacgacccg gcggggtgtt cgtctacacc gtgcggcaca ccggcgacgc
     3481 ccactacggg gccggcgtcg cacacggcga cgacatctac gaacacggcg gcttcgccgt
     3541 ccacttcttc ccccgacgcc tggtcgacga actcgccgcg gggtgggacc tgaccgaagt
     3601 gttcgcgttc gaagaaggcg aactgccgcg ccgcctgtgg cgcgtgacgc agatcgccca
     3661 ctgaacgggg cgcctgggca aggtcaggtg gacccgcccc cgtccggcct gtggtcaggc
     3721 agcggccggc gccatggtga gcagcttgcc catggccgcc agcacggacg gctcgacccg
     3781 gtagtagacc caggtcccgc gccgctcgga ggtgagcagg cctgcctcct tgagcttctt
     3841 caggtggtgg gagacggtcg gctgggatac cccgacgtcg gagatgtcgc acacacacgc
     3901 ctcgccgccc tcgtgcgagg cgaccaagga gaacagccgc agccgcaccg ggtcacccag
     3961 cgccttgaac atccgcgcgg ccgtctcggc ctcctccgcg gtgaacggac gctcggtcag
     4021 gggcgggcag cacggcgcca cggcctccgg cgcctcggat tccagcagcg gcagcacctt
     4081 cgtattcgac atgcatctat gttgacacac gtcgaaccag tcaggccagc ggtgaacggc
     4141 tcggtcgcgg acggggcgcg ccgccaggct tcgcgcgacg cggacggcat cccggtggcc
     4201 cctcgtcgat cactgccgca tttctgatcc actccccgac cgatccactg attcggtgaa
     4261 tgtctatgtt gacgcttgtc gatacaggtg ccatcctggg tcccgcaaga catcgacaga
     4321 cgtcgaaaca aaggggaacc tcgtggctgt gtccattaac agcgtgccca ccaccgacca
     4381 gctgcccgtc gtggtcatcg gagccggtcc catcgggctg gccgccgccg cccacctcgt
     4441 cgagcgtggc ctggaaccgc tggtcctgga ggccggcccc tccgccggca ccgccgtacg
     4501 cgactgggcg cacgtccgcc tgttctcccc gtgggccgag gtcaccgacc ccgcggctga
     4561 gaagctcctc gcccccaccg gctgggtccg ccccgacggc gccatctacc cgaccggcgg
     4621 cgactgggcc gagcagtacc tccagccgct cgccgacgtc ctcggcgaca aggtccgcta
     4681 cggcgtcacc gtgaccggcg tggcccgcgc ggggcgtgac cgcatcgtcg acgcggaccg
     4741 cgacgaacag cccttcaccg tgcacctcca gtcggccgac ggccatgagg agcgcctcac
     4801 cgcgcgtgcc gtcatcgacg cctccggcac ctgggccatc cccagcccga tgggcgccga
     4861 cggcctgccc gccctcggcg agaagactgc ggccgaccgc atcgcctacc gcgtccccga
     4921 cctgaaggac ccggccgccc gggcccggta cgcgggcagg cgcaccgccg tcatcggctc
     4981 cggcgcctcc gccttcaccg cactcgccta cctcgccgat ctggccaagg aggagcccgg
     5041 tacgcacacg gcgtggatcc tgcgccgggg catcggcgcc aacaccttcg gcggcggtga
     5101 cgccgaccag ctcccggccc gcggcgccct cggcctgcgc gccaaggaag ccgtcgaggc
     5161 cggccacgcc agtgcggtca ccggcttccg cacccaggcg gtggaccgcg acggcgacca
     5221 gctcgtcctc gtcgccgagg acggccgccg tctggacccg gtcgacgagg tcatcgtgct
     5281 caccggcttc cgccctgacc tgtccttcct ctccgaggtc cgcctcggcc tcgacgaacg
     5341 cctccaggcc ccgaccgccc tggccccgct gatcgacccc aatgtgcact cctgcggcac
     5401 ggtctatccg cacggcgtgg gcgagctctc ccaccccgaa cagggcgtct atctggtcgg
     5461 catgaagtcc tacggccgcg ccccgacctt cctcgcgatg accggttacg agcaggtccg
     5521 ctccatcacc gccgcactcg ccggcgacca ggaggctgcc gagcgcgtcg aactcaccct
     5581 gccggagacc ggcgtatgcg gtggcgcggg cctctacgac gaccccgacg ccactcagag
     5641 cagcgagggc ggaggctgct gcgcggcccc ggccaccctg cagatcggca tcggcgcggc
     5701 cccgatcacc accactggcg gctgctgaac ccgcaaccac accaaggagg ttcgccatgt
     5761 cccgcgtgca actcgccctc cgcgtcccgg atctcgacgc ctcgatcgcc ttctacagca
     5821 agctgttcgg caccgagccc gccaaactcc gtgacggcta tgccaacttc gccatcacgg
     5881 agcccccgct caagctcgtc ctgatcgaag gcaccgatgg cgaggcgacc cgcctggacc
     5941 acctcggcgt cgaggtcgag acgactgacg ctgtccatgc ggccaccgcc cgcctgagcg
     6001 aggcgggcct ggccacggcc gaggagaacg acaccacctg ctgctacgcc ctccaggaca
     6061 aggtctgggt ccatggcccc ggccaagagc cttgggaggt gtacgtcgtc aaagccgacg
     6121 ccgacaccct caccaagcag cagggcagca cctgctgcgc caccccggcc gacgccaccg
     6181 tcaaggagcc ggccgtcgcg ggcggctgct gctgaccccg ccgatgacca acctccacac
     6241 ccgtgggggc gggnnnnnnn nnnnnnnncc ccgcccccac gctgctctgc ctgccctccg
     6301 cgccaccgag atcaccagct ggggaatcgt ctactacgct tcccggtcct gaacccgcag
     6361 atcacagccg acaccggctg gccgtcgacc gcaaccaccg ccgccgcgcc cgccaccctg
     6421 ctcatgggcc cccgtgcagt tgggcgcggg tggtcagtgg ctgccggtga gttcgccgct
     6481 gagcttctcg tggatctggg cgctgggctg gttgaggccg atgatctcga cagtcttgcc
     6541 gcgctgggtg tacttggtct cgatggcgtc gagggcggcg acggaagagg cgtcccagat
     6601 gtgtgcggcg gtgaggtcga tgacgaccgt gtcggggtcg gtggcgtagt tgaactgggt
     6661 gaccaggtcg ttggaggagg cgaagaagag ttctccggtg acggagtaga cgacctgggt
     6721 gccgtcgggg tcgacgacgg cggtgacgtt ggccaggtgg gcgacgcgct tggcgaacac
     6781 gaccatcgcg gtgatcgagc cgaccacgac gccgatcgcg aggttgtcgg tggcgaccac
     6841 gcaggccacg gtgatgacca tgacggtgat ctcccccgcg ggcatccgct tgagggtctt
     6901 cggggcgatg gagtgccagt cgaaggtcgc gaatgacacc atcaccatga cggcgaccaa
     6961 cgcggccatg gggatgtcgg agacgaccgg gccgaagacg atgcagagca ccatcaggaa
     7021 cgatcccgcc aggaacgtgg acaggcgggt gcgggcaccg gagaccttca cgttgatcat
     7081 ggtctggccg atcatcgcgc agccgcccat gccaccgaag aagccggtga cgatgttggc
     7141 gatgccctgg ccgatggatt cgcgggtctt ggaggagtgg gtgtcggtga tgtcgtcgac
     7201 cagcttggcg gtcatcagcg actccatcag gccgaccagt gccatggcga gcgcgtaggg
     7261 cgcgatggtg gtgagggtgt ccagagtgaa cggcacgtcg ggcaggccgg gcaccggcag
     7321 cgaggagggc agatcgccct tgtcgcccac ggtcggcacc gcgatcccgg ccgcgacggt
     7381 gatcacggta aggatgacga tggacacaag gggtgccggg atcaccttgg tgaccttcgg
     7441 gaagaacacc atgagcgcaa ggccgccgac gatcagcggg tagacgggcc agggcacgtc
     7501 atgcatctcc ggcacctggg cgatgaagat caggatggcg agggcgttga cgaagccgac
     7561 catcacgctg cgcggcacga accgcatcag cttggcgaca ccgagtgcgc ccaggacgat
     7621 ctggaaaacg ccggccagga tcactgcggc gaccaggtgg cccaggccgt gttcgcggtt
     7681 gagcggggcg atgaccaggg cgaccgcgcc ggtggccgcg gagatcatcg cacggcgtcc
     7741 gccgacgatc gagatggtca cggccatggt gaaggacgcg aacaggccga tcgccggatc
     7801 cactccggcg atgatcgaga acgagatcgc ctcggggatc agcgcgagtg cgacgaccag
     7861 accggccagg acctcggtgc gccagaccct gggatcggac agccagtcgg gacgcagccc
     7921 gcgcaggcgc gcggcagggg acagtgcgga ggaagacaag agaagcggaa cctgtcgtac
     7981 tcgggcacac ccggcctcat caaggggcgt gcggaagagc gcggaaggcc ggtcggccat
     8041 ccgccgagtc caccagcggc ggaccgaagt cagagggcag cagcggcgcg gccgcgtcag
     8101 ggccggatcc gctactcagg cgcgaaggat cacggcgggc aggcagcggc gctgggcgac
     8161 atgggcatgc gcacgctctc tcctacaggc atcggccttc accgggggct tcgtcggccc
     8221 cgacacggct gttggtcctt ggctcgtcca tcccgcgcca tgggcgaggg tcggcacgaa
     8281 gccgacccga cgatcactta ctctaccctg acgttacggt agagatcgac gccggccgtc
     8341 tgtggccttg gcgacagacg aggaagggcg cccgcgtgag cagcgagcac atgcagatcg
     8401 gcgaggtcgc agcacggacc gagctgtcgc tgcgcaccat ccggcactac gaggagaccg
     8461 gcctggtcat cccgtccgct cgctcccaag gaggcttccg cctctacacg gagaccgatg
     8521 ttgcgcggct gatggtcatt cgccgtatga agccgctcgg cttcactctc gaccagatgc
     8581 gggacctgct ggaggtcacc gaccggctcg atgccgtccc accgccggga ggcaccgagc
     8641 gggaggaact cctggagcga gtacgccact tcgaacaagc cgccgttgaa cgggtagccg
     8701 acctgcgcaa gcaactgggg cgggccgagg agttcgccgg caccctgcga gaacgcctcg
     8761 cgccagtgcc caccgcctga cgacccggcg gccccggcgc aggcgaagta gcggtccggg
     8821 ggtggcccac gactgctacc gcctcatctg ccgtgtcctg ctgagcaaat ggcccactcg
     8881 aagcgggaaa gattggccca catgcttggg ctgcctggat cctaaggtcg aaggcgacca
     8941 gcgcggcgca cgccagcgac cacctccccc acctcggagg aacccctcat gcaagccatc
     9001 accgtccagg accgcgaggc cggtgccagc ggtctggccc tcgtagagct gccccacccg
     9061 cacgccgcgg agaacgacgt gatcgtgaag gtccacgccg ccggcttcac gccgggcgag
     9121 ctggactggc ccggcacctg gaccgaccgg gccgggcgcg accggacccc gagtgtgccc
     9181 ggacacgagc tgtccggcgt cgtcaccgag ctcggctacg gcaccaccgg tctgaccatc
     9241 gggcagcgtg tgtacggact ggccgactgg gcccgcaacg gcaccctggc ccagtacacc
     9301 gcggtcgagg cacgcaacct cgccccgctc cccgccgacg tcgaccacgt cacggccgcc
     9361 gcgctgccca tctccgggct caccgcctgg caggccctgt tcgaccacgc ccacctccga
     9421 accgggcaga gcgtcctcat ccacggcgcc gcgggcggcg tcggctcgat cgccgtgcag
     9481 ctggcccgcg cggcgggcgc ccaggtgatc ggcacgggac gcgccgacga ccgcgacacc
     9541 gcactcggtc tgggcgccca cgccttcctc gacctccagg ccgagaagct ggaggacatc
     9601 ggcgacgtcg acgtggtgtt cgatgtgatc ggcggcgaaa ttctcgaacg ttccaccgct
     9661 ctggtccgcc ccggcggcac cctggtcacc atcgccgagc ccgtcaccgt ccacccccgc
     9721 gacggccgcg ccgtcttctt cgtcgtcgaa cccgaccgcg tccgcctgag cgacctcgcc
     9781 gaacgagtgc gggacggccg cctcaagccg atcatcggtg acgtgcggcc gctcaccgaa
     9841 gcggtcgccg cgttcacacc ggacaagcgg actcacggca agacgatcat tcgcatcacc
     9901 gaggactgag tcggcgagga gccgcagcac gcgaaatccg tctgcggacg tcgtgtcaga
     9961 ttccttctgg ctgccctgca acccggtgat gtcatgtgat ctaggtgagg ggtgcgttgt
    10021 agcggcgggt gactcggcac cagtcgtagt ggcctcggaa ccatgcccgc aggacgcgca
    10081 cgtagtcggc cagaccggtt ctgccgatga ccggcaccgc cttctccgcg tcaaggcagg
    10141 agacgcattg gacgctgctc gacatggccc aacggagctg agccgcgatg ccgagcccgg
    10201 ctcacgcccg accgggccgg gccagcatca cggtgagcgc cgccgcggtc agcgcgacca
    10261 cggcggcgac cgccccgtag ccgaaggcgt cggccgtggg gccaccgagg agcggagcga
    10321 ccaggtatcc caggatgccg atctgggacc acagcaccat ggctgtcacg atgcgctgcg
    10381 cgggcacggc atccaggagg atgccggttg ctcctgtgtt cgccaggccg atgccgaccc
    10441 ccgcgacagc gagcgccgcg atccacagcg gtacggccga actggctccg gcgaccgcga
    10501 agccgacagc caccggcacg gtcgagccca gcatcacttt ccgcggctgc cagcgagccg
    10561 ccactgcccc ggccaccacg accagtaccg acgtcgccgc atacagcact ccgatctggg
    10621 actggcgcag cttggtcccg aagtgaagcg gcagcacgcc ttcgagtgtc ccgagcgcca
    10681 tgaccgcgaa ggcgatggag gcagcggccg cgaggaatcc tggcgagcgc accgcgtgcc
    10741 ggtcggtggt gaatgccccc accgctgaag gaagccgaag cgtcgccacc ggtacgacgg
    10801 cgaggacgac aagggccaag taggcgacga aggggccgcg taccccgtgg accgccccga
    10861 gcagcgggcc caggagtccg cccgcggagt aggcggcgta gatgcggctc atgcacaggt
    10921 actcctgacc gggccaggcg gccagagttg cgaaggtgat ccccagccac aggcacccgg
    10981 agcccaggcc catcaccaga cgcgagaccg tgaaggcggc cagatcagag ccgaagacga
    11041 accccaggct gcccgcggcg accagcagca gccccatcag gagcagccgc gccgggctgc
    11101 tgcgctggac cacggccccg cccacggcga agcccgcgac catccccaac gggaacatgg
    11161 cgaccagcaa tcccatcgcc gtggcaccgg cgccggtccg cgcggccagg ccaggaagca
    11221 ccggcgcgat caggctgtat ccggccgcgt ccagcgcacc cagtgccagc agcaaggcat
    11281 agaccgctac ggaacgcatc ggtgcccgct ccgcccgtcc ggcgccgacg tccatcagcc
    11341 gcttcgccag cgcccgcgca ccggaccgct tccgctccgc gcaggagcgg ggcgccccat
    11401 gacgacatca gcagccgagg ggaaggcatc gacgcattcc tcgttcagcc ggtaccggct
    11461 gaacgagcct tcccgctcga ccagcacgaa ccccacctcc gccaggccct tcaggtggtg
    11521 cgagaccgtc gactgcccca ccgccacagc ctcgacgatc tgccccactg ccagaggctc
    11581 actgctgcgt gccagcagag tcacgatctg aatccgggtg gcgtcggcca gcgccttgaa
    11641 ccagctcgcg tactgctcgg cctcggagcg ctccaaaaat tcactcatcg gtcatcgacg
    11701 atagtcgatg accgagctcg ttgcgacccc attgcaccca tcgaccaccg cggaggaggc
    11761 cgagcggacc gcgcggatgt tcaaggcgct cggggacccc gtccgtctcc ggctgttctc
    11821 ggcggtggcc tcgcacgagg gcggcgaggc atgcgtgtgc gacatctccg atgtcggcgt
    11881 ctcccagccg accgtggggt ggtccgcccg gcttccgcgg cccacctcca tgtcccggcg
    11941 gggtggggcg cgagccgaca ggtagaccac ggccatggtt gcggcctgta cgcctacgcc
    12001 ttccgaaaag agtcgatgcc tcggcgacga cgcggggcgc gctgtctggg tcgaccgctg
    12061 tgggtcgggc gactcggagg cgccggtgtc gatgtgcacc catgtccagg ccgcgagcgg
    12121 cggcgggtcg tgggttcgtt cagctgacgg cgcgtcgtcc gccctcagac gccgaggagc
    12181 gcggcgatct cgcgggccgc gtcgcgggcc ggcctgccga cgccgatgag ggtggcggag
    12241 gcggggccgg tccagtcgcc gtagccgagc aggtgcaggc gcggctcgtc caccgcgcgg
    12301 gtgccggcgg taccgatgtg gccgcggcgt ccgcggagtt ggagcggggc caggtgggag
    12361 agcgccgggc ggaagcctgt gcaccagatg atcgcgtcgg cctcggctcg ggtgccgtcg
    12421 gcccattcga ccccgccggg aacgagtcgg gtgaacatcg gcacggtctt cagcaggccg
    12481 cgctcccgtg cctgcctgac gggaggtacg gcgacgatgt cgcccagtga ggcgacgccg
    12541 ccggtgtcgg tgcgtccctc gtcgagggcg cggcgccggg cggaggccac gtcgaacagc
    12601 acccggccgt cgatgtcgtc ggccaggaag cggggcgggc gctgggtgac ccaggtcaag
    12661 tgggtgttgt acgccaggtc ggcggcgatc tgggcgccgg agttgccgcc gccgacgacg
    12721 atcacgcggc ggcccgcgaa gtcctgtggg cgccggtact ccacggtgtg cagctgcctg
    12781 ccgccgaaag actcccggcc cgggacggcg gggaggaagg ggcgctgcca tgtgccggtc
    12841 gcgctgatga cggcctgggt gtgccaggtg ccggaatccg tctccacccg taggagctga
    12901 cttgcgtcgc ggtgtacgcc gagcacacgt accggccggc gcacgtccag cccgtaccgc
    12961 ttctcgtagt cgcgcaggta tgtcaccacg tgcgccgcgt ccgggtattc ctcgcccgac
    13021 tggggcggca tgagccatcc gggcagggag gagtaggagg ccggggagaa caggtgcagg
    13081 gagtcccagg tgtgctgcca cgctccgccg gggtcggcct gggaatcgag gatgacgaac
    13141 gtcaggcccc ggcggcgcag gtggtacccg gcggcgagcc ctgcctggcc gccgccgatc
    13201 accaccacct gggtcgtccg cgtcatacgg cgggctgctc cgcggccgtc cgggcgggcg
    13261 cgaagatcag cgccacgagc gccagtccga ccaccgcgcc gacgatctgc atgccgatga
    13321 agcccgcgag ggaaccgggg gcgatgcccg cgaacgtgtc cgtgaaggcg cggccgatcg
    13381 tcaccgccgg gttcgcgaag gacgtggagg acgtgaacca gtacgcggcg ccgatgtagg
    13441 aggcgacggc caccggggcg aagcgcagac ggtcggtgcg ggccaggccg aagatcagca
    13501 ggatcaggcc ggcggtcgcg accacttcgc caaggaggag atgtcccgct gagcggtcgt
    13561 gcgtcgacca tttcacgagc ggttcgccga acatcgcatc cgccaggacg gcgccggcta
    13621 tcgcgcccac gatctgcgcg gggacgtaca cggccgcctc acgaagtgtg acgccggcgc
    13681 caccgcgccg ggcggtccac cactccgcca gggtgaccgc cgggttgaag tgcgcgccgg
    13741 ataccggccc gagcagggtg atcagcacgc cgaggccgaa gaccgtggca agcgagttgg
    13801 ccagcagctg cacgccgacg tcctgggtga gctccgtggc ctggatgccg gaaccgacga
    13861 caaccgccac cagggccgcg gtgccgacca gttcggcggc ggcccgcgcg aacagcgggg
    13921 cgcggggtgg agtggcccct ggggcaggtt ggggagagac gtcggctctg gctgactgcg
    13981 cagcggactc gtgcgtggcg gtcaacaaag actccttggt gcagtcgccg ggcggcgagg
    14041 gatcaggggc aggaccgctt gttgtcggcg gcggcacggg cggcttcggc cagatcggcg
    14101 aactggcccg cgagcgaggc gatgacgtcc gggcgcagct tgtagtaggt gaaccggccg
    14161 catggctccg tctcgacgac tccggcctcg cgcagcactc tcagatggtt ggagaggttg
    14221 gtctgcttgg caccggtctc ctccacgagg tgggtggtgc acagcgtctc tttggcgagg
    14281 agggtcacga tccggagcct gagcgggtcg gccagaaccc ggatcagatc agtgtcgact
    14341 gacgtcagca tgcactgata ctgtcacatc agtggtgact gacaccagcg ggtattgatg
    14401 tgtgccgtgc ccgtatttcc cttgcgagac aagagagacc tctgatgtcc gacaagccct
    14461 ccgtgctctt cgtctgtgtc cacaacgccg gccgttccca gatggccgcc gcgtggctga
    14521 cccacctggc cggagaccgc gtcgaggtcc gctccgccgg ctccaacccc ggcgcgaacg
    14581 tcaacccggc cgccgtcgag gccatggccg aggtcggcat cgacatctcc gccgaggtcc
    14641 cgaagatgct caccgtcgac gccgtcaagg agtcggacgt ctgcatcacc atgggctgcg
    14701 gcgacacctg cccggtcttc cccggcaagc ggtacctgga ctggcagctg gacgacccgg
    14761 cgggccaggg cgtcgacgcc gtgcgtccga tccgcgacga gatcaaggtg ctcgtcgagg
    14821 gcctgatcga ggagatcgca ccggagcccc aggcatgagc accgcgacgg acgtacgcaa
    14881 cgtcatcgtc atcggctccg gccccgccgg atacaccgcc gccctctaca ccgcccgcgc
    14941 ctcgctgaag ccgctggtgt tcgaaggcgc ggtcacggcc ggcggcgcgc tggtgcagac
    15001 gaccgaggtg gagaacttcc ccggcttccc gggcggcatc atgggcctgg agctcatgga
    15061 caacatgcgg gcccaggccg aacgcttcgg cgccgagctg gtccccgacg acatcgtcgc
    15121 cgtcgacctc accggcgagg tgaagaccgt cacagacagc gcgggtacgg tccaccgggc
    15181 caaggccgtg atcgtggcga ccggctcgca gcaccgcaag ctcgacctcc cgggtgagga
    15241 cgcgctctcc ggccgtggag tgtcgtactg cgcgacctgc gacggcttct tcttccgcga
    15301 gcacgacatc gtggtcgtcg gaggcggcga cacggcgatg gaggaagcca ccttcctctc
    15361 ccgcttcgcc cgctccgtga cgatcgtcca ccgccgcgac accctgcgcg cctccaggac
    15421 gatgcaggac cgcgccttcg ccgaccccaa gatctccttc gcctggaacc gtgaggtcgc
    15481 cgagatccac gaggacggcg gcaaactcgc cgggctcacc ctgcgcgaca ccgtcaccgg
    15541 cgacacctcc cacctaccgg ccaccggcct cttcgtcgcg atcggccatg acccgcgtac
    15601 cgacctggtc accggccagc tggacctgga cgaggagggc tacctcaagg tcgcctcccc
    15661 ctccacccgc accaacatcc ccggcgtctt cggcgccggt gacgtggtcg accacaccta
    15721 ccgccaggcc atcaccgcgg cgggctccgg ctgcgcggcc gcgctggacg cggagcggta
    15781 cctcgccgcc ctcagcgaca ccgacgccgc gggcgaaccg gccgtagcag ccgtctgacc
    15841 tgctcctggg acaccgtcct ggctctcaag aacgtcaccg aggactcctt cgaacaggac
    15901 gtcctcaaca gcgacaagcc ggtactggtc gacttctggg ccgcctggtg cggcccctgc
    15961 cgcgagatcg ccccctcgct ggaagcgatc gccgccgagc acggcgacaa gatcgagatc
    16021 gtgaagctca acatcgatga gaacccggcc atcgccgccc gcgacggcgt catgtccatc
    16081 ccgacgccgc acctctacaa gggcggcgag gtcgtgcaga ccatcgttgg cgccaaggcc
    16141 gaggccgctc tggagcgcga actcgcctga cacctcacgc cggtggggtg cccacagcac
    16201 cccacccgtc ctctctccga ttccttcgac ggaggtatcc cggtgggcgg caagcgcatc
    16261 gtcgccatcg gcggcagcga cgccggcatc agcgccgctc tgcgcgcccg cgaactggat
    16321 cccgacagcg aggtcaccgt ggtcgtggcc gacgcctacc cgaaattctc catctgcggc
    16381 atcccgtacc acgtctccgg cgaggtcggc cactggagcg acctcgccca ccgcaccctc
    16441 gccgaactca aggccaccgg catactggtg cacaccgaca ccctcgccac cggcatcgac
    16501 gtgaccggca aacagctgac cctgcgcgac gccgagggcc gtaccgatca actgccgtac
    16561 gacgcactga tcgtcggcac cggagccgtc agcgcccgcc cgccgatcgc aggcctgtcc
    16621 gggtccgacg cactcggccc gcaggacggt gtccacctgc tgcacagcat gggcgacacg
    16681 ttcgcgttca tgcagagtct cgccgagcgc cgccccaagt cggtcgtcgt gatcggcgcg
    16741 ggctacatcg gcctggagat ggccgaggcc ctgaccaccc gcggcctgaa ggtcacccag
    16801 atcgaggccc tgcccgaagt cctgcccacc gtcgatgtgg aactcggcgc tctcgtgcac
    16861 gacgaactcg ccgcgcacgg cgtcgaggtc atcaccggca cccaggtctc ggcgatcacc
    16921 cgcgccccgg ctggagacct gctgcacgtc cacgccgcgg gccccggcgg cgcagccttc
    16981 acccggggca ccgagctcgt cctggtcatc gtcggcgtac gcctcggcgc caagggcgcg
    17041 atcgacgtcg acgagtacat gcgcacctcc ctacccgacg tatatgcggc cggcgactgc
    17101 gccgtcaccc accaccgcct cctcggaaag acctggctgc cctcaagacc accgctcaca
    17161 agcagggccg catcgcgggc gagaatgcac ttggcggtac ccgttggttc gccggcagcc
    17221 tcggcaccca ggtcgtcaag gtcttcgatc tggtcgccgc ccgcaccggc ctgcgcgacg
    17281 ccgaggcgca atccgcggga agaggctgga ctcaggccac caccgccagc cgtcccgtgg
    17341 tccgcgctca cccctgcgag cgcagaaccc agcctgaagg gcctggacag cacggcgtac
    17401 ctataacgtt ccagggcaca cgacgccggc cccggagaag atcgtgatca cccccaggcc
    17461 ggaaaagtgt gccggccttg cgtccgtagc accggtgcag ccgtcaagcc gcgcaaaggc
    17521 gcgttcgatg ctccagaggt ggcgccccag tcgcttggag tcccccacgc ccatgcgggt
    17581 gatgcgctcg gtgacgccac gtccacgtaa ccgctgcagc aggtgaggcc gtcgcatgaa
    17641 ccaccgatgg gccgttgccc cctgagagcc cgaaagacgc tcccgccagt tgctgccacg
    17701 tacagcccca catcgcaacg aacaccaccg ccgccatgac ctcccggccg tcacgccgac
    17761 gccgaccacc catgagccca cgacagcacc tcaggcacca ccttcaggaa cagctcccac
    17821 agcccatccg gcaccaaccc caccagaagc cccacggcca gctccgccta cggcgctcac
    17881 cggaacacac ggtctcagtc cataccgccc ggagccaacg gcagactgtg gtcagcatgc
    17941 cgccccggca ggcgatctcg cggctgctgc cgagcatggg aactgtccga atgcgccgcc
    18001 gcgaggcggc cggtgccatg gtgagtggct ccgccctcgg tcatccggcg gccgccacga
    18061 gggctgccgt gaggagcgca gggggaccgt ccagcgtgtc gctgtgcagg gcctcgacgc
    18121 ggtgcaccaa tcgtggtgcg gagaccggga ccgcgctgat gccgggcgcg cctttgatca
    18181 ccggccgagg cagcagcgcg agtccgaggc ctgcggcgat gagcgtgatg agtccgcgca
    18241 cgtcgcctcc ttcgtagcgc agggacgcgc ggtgaccgtc ggctccgctc gcggtgcgca
    18301 actgcctcag cggtatggca gtgtcgggtg cgtcgatcca ccgtgcgtcg gcgaggtcgg
    18361 ccaagcgcag accggcccgg tcggccaggg gatgctgggc gggcagtgcc acggcaagcg
    18421 ggtgttcggc gacggctgtc gccctgagca ggccggcatc ggggagatgg agcgggtcgt
    18481 tgggggcggc cattccgtcg accaggccga ggtccagggc agcggtcgcg acgtcgcggg
    18541 tgagggcttc gcggccgagg acacgcactg tcacctccaa tcggggctgc gatcggcgca
    18601 cttctgcgag cgtcccggtg aactgccgcg tcatggccag cggtgagact ccgatgacga
    18661 tgcgggcggc gggtgccacg gtcaggcgcg cgatatccgc gcgggcggcg tccaatcgca
    18721 gcagcagtgg cccggcgtgc tcgagcagcc gggtaccgac gccggtcgga gtgaccgggc
    18781 gccggtgcag gaggaccgct ccgaggtcgc tttcgagtgc ggcgatgtgc tgggacaccg
    18841 ccgactgcgt gtaacccagt tcgcgagccg cccgggaaaa ggaagcgcag cgggccacgg
    18901 ccacgaacgt gcgcagaagg tgcggatcca tggctatcag tatcgctaat ggaagggtca
    18961 tgcatcatcg ttggtgctgt acttggttgc ccggtcagga tgtccacatg cctgagcttg
    19021 agaccttccc gacggcccgc gtcgccctgg tgggcgaccg ttcgcccagc gtccgcgccc
    19081 acacccgtat ccctgctctc ctcgaagcac tcgcccagca tgatcagttg gtcctggacg
    19141 cctactggat cccgaccgag gacgctgaat ccgccggtgc cctcaacgga ttcgatgcca
    19201 tctggctggt gcccggcagc ccgtatcgca gcgaagccgg agcactcgcg gcgcctcgct
    19261 cggctcgcga gcaagggatc ccgtttctcg gcacctgcgg cggctttcag cacgccgtcc
    19321 tggagttcgc gcgcgacgtg tgcggactca ccggcgtcaa ccacgcggag aaccggccgg
    19381 aagcggagga cctgctgatc gtcccgctgg catgctccct ggtcggtcac gaaggggcgg
    19441 tcaaggtgga ggcggggtcc ttggcggaac gtgtcctggg ggctgagcgg accgtcgagc
    19501 gctaccactg ctcttacggc accagcccgg cctatctgga cgtgctacgt gcgcacggcc
    19561 tgcgcttcag cggcgtcgac gaggcgggcg atgtgcgcgt cgccgagctg ccggggcacc
    19621 cgttcttcct cgccaccctg ttccagcccg aactcacggg agacggcacc cggccccatc
    19681 cgatcatccg cgcgctggcc tccgcagcgg tcgagcgtgc caccaagcga tcggcgcgag
    19741 cgttcgcctg atcccagccg atcatggcac tcgtcacgca ctcagcgagg gcgcacagca
    19801 gcgatcaccc tcctgcgaca ggaagtccag aaagcgaaag acgctgtcgc aggccggccc
    19861 aggggagaaa ctgccgcacc ggccccgctg gcagaggaca ctcaaccagt ggctcctgcc
    19921 gcctcgtacg ccaccccctc tccctcaacc ccgacgccct cgatccgggg cccgtcttcg
    19981 accgtgccgt cgcctggctg aggtgccgga cggccatcgg gcgatggacg accgatcggc
    20041 gctgactgtg cgcatcaccc tcgttgatgt caggcggcgc gcttcacgtg gcggaccagc
    20101 cacatcagca gggcgtccag gtcggctgcg gccgagagga tccggtcgac cgcttcgggg
    20161 gtgtg
//
