LOCUS NZ_BNBM01000003 21086 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence03, whole genome shotgun sequence. ACCESSION NZ_BNBM01000003 VERSION NZ_BNBM01000003.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 687919) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 325816 Orig. end :: 346902 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000003.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..21086 /candidate_cluster_numbers="1" /contig_edge="False" /product="terpene" /region_number="1" /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /tool="antismash" cand_cluster 1..21086 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /kind="single" /product="terpene" /protoclusters="1" /tool="antismash" protocluster 1..21086 /aStool="rule-based-clusters" /category="terpene" /contig_edge="False" /core_location="[10000:11086](+)" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" /tool="antismash" proto_core 10001..11086 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)" /neighbourhood="10000" /product="terpene" /protocluster_number="1" gene complement(361..1680) /gene="aroA" /locus_tag="IE325_RS10450" /old_locus_tag="GCM10018780_21090" CDS complement(361..1680) /EC_number="2.5.1.19" /GO_function="GO:0003866 - 3-phosphoshikimate 1-carboxyvinyltransferase activity [Evidence IEA]" /GO_process="GO:0009073 - aromatic amino acid family biosynthetic process [Evidence IEA]" /codon_start=1 /gene="aroA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019522882.1" /locus_tag="IE325_RS10450" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21090" /product="3-phosphoshikimate 1-carboxyvinyltransferase" /protein_id="WP_190069510.1" /transl_table=11 /translation="MAQNPAAHPALWPAPQASGPVDATVHVPGSKSVTNRALVLAALAS EPGWLRRPLRSRDTLLMAGALRTMGVGIEEGVGPEGTGEAWRVLPAGLRGPATVDVGNA GTVMRFLPPVAALADGPVRFDGDPRSYERPLHGVIDALRALGARIDDDGRGALPLTVHG GGALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSSLPSMPHIRMTVDMLRAV GAQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALVTGGKVLIPDWPAR TTQPGDRLREIFTEMGGSCELTEYGLVFTGSGAVHGIDVDLSEVGELTPGIAAVAAVAD SPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYEDHR MATAGAIIGLAVEGVRIENVATTAKTLPDFPELWTGMLGA" gene complement(1766..2488) /locus_tag="IE325_RS10455" /old_locus_tag="GCM10018780_21100" CDS complement(1766..2488) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003998067.1" /locus_tag="IE325_RS10455" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21100" /product="M50 family metallopeptidase" /protein_id="WP_190069511.1" /transl_table=11 /translation="MDSTASASLASLWDEVSGTQPDPDLWVVIAALVVALAFVVPHVLW RLSRNAITIAHEGGHGLIALLTGRTLTGIRLHSDTSGLTVSRGKPHGIGMILTAAAGYT APPLLGLGGAALLAAGRITLLLWLATVLLVAMLVMIRNAYGALTVFVTGGTFVLVSWFT GPQVQAAFAYVVVWFLLVGGVRPAFELQAKRARGGAGDSDADQLSRLTHVPAGLWLFLF HAVSLCSLIGGGRWLLEV" gene 2539..3354 /locus_tag="IE325_RS10460" /old_locus_tag="GCM10018780_21110" CDS 2539..3354 /EC_number="3.4.-.-" /GO_function="GO:0003697 - single-stranded DNA binding [Evidence IEA]" /GO_function="GO:0008233 - peptidase activity [Evidence IEA]" /GO_process="GO:0009432 - SOS response [Evidence IEA]" /GO_process="GO:0018142 - obsolete protein-DNA covalent cross-linking [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019980380.1" /locus_tag="IE325_RS10460" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21110" /product="SOS response-associated peptidase" /protein_id="WP_190069512.1" /transl_table=11 /translation="MCGRYAASRRPEDLAGIFEIETWEPEESLEADYNVAPTKEVLVVL DRPLKDVDDPAPVRQLRKLKWGLVPSWSKTPESAFKMINARAETVHEKPSYKRAFSSRR CIIPADGYYEWVTGKQERDLEVEGKKKRPRKQPYFVLPADGTVFAMAGLYEFWRDKTLP DEHPQAWWVTCSVITTEAETTPLAVAPEEGPHTLAEIHPRMPLMLTPDRWDAWLDPSRK DPEELRTLLDPPPAGLMRAYPVSTLVSNVRNNGPELLKELDGPEEGTLF" gene 3365..3994 /locus_tag="IE325_RS10465" /old_locus_tag="GCM10018780_21120" CDS 3365..3994 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003998051.1" /locus_tag="IE325_RS10465" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21120" /product="alpha/beta family hydrolase" /protein_id="WP_190069802.1" /transl_table=11 /translation="MTTEIIGTEAGDARITWHPAKKARLVLAASHGAGGGIGARDLVAL AEALPAHGVTVALVEQPWRVAGKKVAPAPKTLDIGWRGLWPALAVPGLPVIAGGRSAGA RVACRTAVELGAHAVLALSFPLHPPGKPEKSRAEELLGSGVPTLVVQGGNDPFGKPEEF PDGDFELVEVPYGDHGLAVPKRAPLDQDEAVALVTDAVMKWAGSLG" gene 4252..4935 /gene="sigR" /locus_tag="IE325_RS10470" /old_locus_tag="GCM10018780_21130" CDS 4252..4935 /codon_start=1 /gene="sigR" /gene_functions="regulatory (smcogs) SMCOG1032: RNA polymerase, sigma-24 subunit, ECF subfamily" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003973756.1" /locus_tag="IE325_RS10470" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21130" /product="RNA polymerase sigma factor SigR" /protein_id="WP_190069513.1" /transl_table=11 /translation="MGPVPGTDAGTDNGQAEQPEGLGTSAESTAERSARFERDALEFLD QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIAV YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGESNEA KGSGS" gene 4932..5234 /gene="rsrA" /locus_tag="IE325_RS10475" /old_locus_tag="GCM10018780_21140" CDS 4932..5234 /GO_function="GO:0016989 - sigma factor antagonist activity [Evidence IEA]" /GO_process="GO:0045454 - cell redox homeostasis [Evidence IEA]" /codon_start=1 /gene="rsrA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020136687.1" /locus_tag="IE325_RS10475" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21140" /product="mycothiol system anti-sigma-R factor" /protein_id="WP_190069514.1" /transl_table=11 /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFKQHFQECSPCL EKYGLEEAVKKLVKRCCGHDDVPTDLRAKVLGRLDLIRSGQAVPEHDVTATPQES" gene 5343..6632 /locus_tag="IE325_RS10480" /old_locus_tag="GCM10018780_21150" CDS 5343..6632 /EC_number="3.1.4.-" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007491202.1" /locus_tag="IE325_RS10480" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21150" /product="HD-GYP domain-containing protein" /protein_id="WP_190069515.1" /transl_table=11 /translation="MEATPAPARGYVLCVALGALYCVHTLPADAVPWWAVALLAALYAG GERLSGSFYPVLLAGAFLLPPSAAALVAVPGALLAPAGGRPRLLRRVWRAAQLVVVVWV AARVHGELGEHDAVVAADFPHALLPVGAAVLAFCLALSLLDTGILALAERVPPWRAWRE QFPRSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWAFAQYHRERAAHQAT IRALVQAVDIKDGYTRGHSERVGQASMMIARELGLAGERVEVLRFAGILHDVGKLGVPT RLLRKNGPLTPEERRVIELHPEYGHEMVRGISFLGEARAAVLHHHERLDGSGYPYGLSG SQIPESARVVAVADAFDAMTSTRSYSRARPVSEALRELEKCAGSHFDPRMVTALAGALD QHGWHPAVTADEPAPPTAGPSADRVPGARR" gene 6668..7909 /locus_tag="IE325_RS10485" /old_locus_tag="GCM10018780_21160" CDS 6668..7909 /EC_number="3.1.4.-" /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003998047.1" /locus_tag="IE325_RS10485" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21160" /product="HD-GYP domain-containing protein" /protein_id="WP_190069516.1" /transl_table=11 /translation="MSAPRPPVLLTLIHACAALLATGCVLGILAGGLAERATALAFGVL ITLGELTRWAGAEGREAAPLGAAAALSYALLGDNGSEPTQHGAVQVVGVVLAASLLGSV PHIARGRPVLDHLTRRVLTVGFAAVCFQPLSNQGTFDGWGTSYALLLLAILTLTALCDA LLAAALAHTRTRWPFGPLLRDELRATLGIGSAVCATGAVMALAVAVIGLWALPVFSVPL LLTQLSVRRYSAVRTTYRQTIASLARATEIAGYTPAGHARRVAALSRDVGRDLGLTEAE LTVLEYAALMHDIGQLSLVDPVPDGATAVLPVEKQRRIALLGGAVVRQTGVNPQVALVV ERLADPCPEQPLPARIVRAVNAYEEMARDAGPGGPLKALEELRLGTAGEYSAEVVESLA QVLSREGLATPLAG" gene 8019..8999 /locus_tag="IE325_RS10490" /old_locus_tag="GCM10018780_21170" CDS 8019..8999 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019889310.1" /locus_tag="IE325_RS10490" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21170" /product="hypothetical protein" /protein_id="WP_190069517.1" /transl_table=11 /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA RRAWQAYGLRVPGGATDSGEPVGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL PSSGRRWGEVVLHDGVPHGERTTTSGHAYPVFDEIELWAPSPVPTWVVLLEAATEADRD ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR TDGQLWVPERECGVAAPAALVRGLLDGWVADSPDSRDWRDLEEVC" gene 9141..9791 /gene="def" /locus_tag="IE325_RS10495" /old_locus_tag="GCM10018780_21180" CDS 9141..9791 /EC_number="3.5.1.88" /GO_function="GO:0042586 - peptide deformylase activity [Evidence IEA]" /GO_process="GO:0036211 - protein modification process [Evidence IEA]" /codon_start=1 /gene="def" /gene_functions="biosynthetic-additional (smcogs) SMCOG1275: peptide deformylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004983603.1" /locus_tag="IE325_RS10495" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21180" /product="peptide deformylase" /protein_id="WP_190069518.1" /transl_table=11 /translation="MAQQDTEQQHAGVLPVDDEGFVVDTEDAEERENAWRERGTSRPIT VVGNPVLHKECKDVTEFGAELEQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD QGERHVGVVCNPKLVELPAEQRRLDDSNEGCLSVPTAYAALARPDYAEVTGQDEKGNPI KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYAVVPND" gene 10001..11086 /gene="cyc1" /locus_tag="IE325_RS10500" /old_locus_tag="GCM10018780_21190" CDS 10001..11086 /EC_number="4.2.3.37" /GO_function="GO:0052680 - epi-isozizaene synthase activity [Evidence IEA]" /codon_start=1 /gene="cyc1" /gene_functions="biosynthetic (rule-based-clusters) terpene: T1TS" /gene_functions="biosynthetic-additional (smcogs) SMCOG1052: Terpene synthase/cyclase metal-binding domain protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009190552.1" /locus_tag="IE325_RS10500" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21190" /product="epi-isozizaene synthase" /protein_id="WP_190069519.1" /sec_met_domain="T1TS (E-value: 2.5e-61, bitscore: 203.6, seeds: 237, tool: rule-based-clusters)" /transl_table=11 /translation="MHAFSDSTTATSTAVQVPPSLSLPVIEAAFPRRLHPYWPRLQDKT RAWLLQKRLMPADKVEEYADGLCYTDLMAGYYIGAPDDVLQAIADYSAWFFVWDDRHDR DIVHRRPAAWRRLRFRLHTALDSPEDHLHHEDPLVAAFADSVGRLFSFLPGTWNARFAR HFHAVIEAYDQEFHNRMEGKVPTVEEYLELRRLTFAHSIWTDLLEPSVGMELPESVRKY PAYRRAALLSQEFAAWYNDLCSFPKEIAGDEVHNLGISLITHKGLTLEETIAEVRRRVE DCISDFLVAEREALEFAGLLADGTPRGAELGTAVRACVGNMRNWFSSVYWFHHESGRYR VDSWDDRSTPPYVNNEAAGEL" gene 11083..12429 /locus_tag="IE325_RS10505" /old_locus_tag="GCM10018780_21200" CDS 11083..12429 /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /GO_function="GO:0005506 - iron ion binding [Evidence IEA]" /GO_function="GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1034: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019058302.1" /locus_tag="IE325_RS10505" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21200" /product="cytochrome P450" /protein_id="WP_190069520.1" /sec_met_domain="p450 (E-value: 5.8e-71, bitscore: 234.8, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MTTVLELREPPLAGGGVPLLGHGWRMVRDPLAFVAALRDHGDVVR IKLGPKTVYAVTTPDLTGALALSTDFEIAGPLWESLESLLGKEGVATANGPRHRRQRRT IQPAFRLDAIPGYGPIMAEEAHALTERWRPGETVDCTAESFRIAVRIVARCLLRGAYMD ERADRLCAALDTLFRGMYRRMVIPLGPLYDLPLPANRRFNGALADFHLLVDEVIAERRA SGQKPDDLLTALLHAKDENGDPIGEQEIHDQVVAIFTAGTETVASTILWLLHVLAEHPE HADKVSAEVESVTGGRPVAFEDVRALRHTNNVVVEAIRLRPAIWILTRRAVADTSLGGY RIPAGADIVYSPYAVQRDPKSYVRHLDFDPDRWLPERVKEVPKYAMSPFGVGNRKCPSD HFSMAMLSLITAALAGRYRFEQASGSNDSTRVGITLHPHTLLLTPVERE" gene complement(12431..13396) /locus_tag="IE325_RS10510" /old_locus_tag="GCM10018780_21210" CDS complement(12431..13396) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1287: AraC family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003998042.1" /locus_tag="IE325_RS10510" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21210" /product="GlxA family transcriptional regulator" /protein_id="WP_190069521.1" /transl_table=11 /translation="MLKNVAAVLLNGVHPFELGVVCEVFGIDRSDEGLPTYDFAVVSAE GPTLGTHVGGLSVSTPYGLERLEEADLIAVPAGSDYVVRDYPPELLDSLVRAVERGARV LSVCSGVFVLGAAGLLDGRRCSAHWKHAGELTRQHPRAIVEPDVLYVDEGPVITSAGTA AGIDACLHIVRQEQGPEVANKIARRMVVPPHRDGGQAQYIERPLPRSQCDTVGEVLAWM ERHLDEDVTVEQLAERALMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETV DAIAGRTGFGTAAALRHQFVRTLGTTPNAYRRTFQGPEAA" gene complement(13617..14630) /locus_tag="IE325_RS10515" /old_locus_tag="GCM10018780_21230" CDS complement(13617..14630) /EC_number="1.17.4.1" /GO_component="GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]" /GO_function="GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA]" /GO_function="GO:0046872 - metal ion binding [Evidence IEA]" /GO_process="GO:0006260 - DNA replication [Evidence IEA]" /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014674901.1" /locus_tag="IE325_RS10515" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21230" /product="ribonucleotide-diphosphate reductase subunit beta" /protein_id="WP_190069522.1" /transl_table=11 /translation="MSTRNANLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH SDVADLAKLSEGEQHMIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE AVHVQFYLTLLDTYLPDPEDRAAAFDAVENIPSIREKAEFCFKWINEVEKLESLQTQAD RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD VVDTVRKEEPELFDDQLQQEVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF" gene complement(14630..16990) /locus_tag="IE325_RS10520" /old_locus_tag="GCM10018780_21240" CDS complement(14630..16990) /EC_number="1.17.4.1" /GO_component="GO:0005971 - ribonucleoside-diphosphate reductase complex [Evidence IEA]" /GO_function="GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Evidence IEA]" /GO_process="GO:0009265 - 2'-deoxyribonucleotide biosynthetic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015657909.1" /locus_tag="IE325_RS10520" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21240" /product="ribonucleoside-diphosphate reductase subunit alpha" /protein_id="WP_190069523.1" /transl_table=11 /translation="MTIAPADPVSVTELKTDGPGTALLRTLTELTADLLDADPGRVAAA ALRGRSARADEAELRELATEAAAGLISEDPAYSRLAARLLTLSIAAEAASQGVTSFTGS VAVGHREGLIADRTAEFARIHAARLDALVDTGADDRFGYFGLRTLHSRYLLRHPITRRV IETPQYFMLRVAAGLAEDDSVRALDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQMSSC YLLDSPLDELDSIYDRYHQVARLSKHAGGIGIAYSRIRSRGSLIRGTNGHSNGIVPFLK TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE FMRRVNADAVWSLFSPADVPELVDLHGEEFDAAYRKAEAAGLAKKTIPARDLYGRMMRT LAQTGNGWMTFKDAANRTANQTALPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLGA FVDNGDIDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVFF KLRLPFDSPEAKALSTRIAERIMLAAYEASADLAERSGPLPAWEKTRTAQGVLHPDHYP DAELTWPERWAALRGRIATTGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETL SGEFLQVNSYLVDELKALGVWDARTREALRESNGSVQDFAWIPADVRALYRTAWEIPQR GLIDMAAARTPFLDQSQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIAR AAQAQAAIPAQQPAPEDAVACSLENPESCEACQ" regulatory complement(17114..17260) /bound_moiety="adenosylcobalamin" /db_xref="RFAM:RF00174" /inference="COORDINATES: nucleotide motif:Rfam:14.4:RF00174" /inference="COORDINATES: profile:INFERNAL:1.1.5" /note="cobalamin riboswitch; Derived by automated computational analysis using gene prediction method: cmsearch." /regulatory_class="riboswitch" misc_feature complement(17240..17254) /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: medium, score: 24.21" /tool="antismash" misc_feature complement(17271..17285) /note="TFBS match to NrdR, Represses ribonucleotide reductase encoding genes, confidence: strong, score: 25.12" /tool="antismash" gene complement(17296..17802) /locus_tag="IE325_RS10525" /old_locus_tag="GCM10018780_21250" CDS complement(17296..17802) /EC_number="2.3.-.-" /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /GO_function="GO:0016746 - acyltransferase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019326961.1" /locus_tag="IE325_RS10525" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21250" /product="GNAT family N-acetyltransferase" /protein_id="WP_190069524.1" /transl_table=11 /translation="MDIVIRRAEPGEYEPLGEITARAYLQDGLLDFGESDEYLSELKDV AGRAAAAEVLVAVENGRLLGGVTFVPSGGPMADIARPSEAEIRMLAVAHDGRGRGAGEA LVRACVDRARATEGCARIVLSTQRTMHGAHRIYERLGFVRTPERDWNPIPHLDDITLLT YELTL" assembly_gap 17853..17869 /estimated_length=17 /gap_type="within scaffold" /linkage_evidence="paired-ends" gene complement(17887..19515) /gene="mctP" /locus_tag="IE325_RS10530" /old_locus_tag="GCM10018780_21260" CDS complement(17887..19515) /GO_function="GO:0015293 - symporter activity [Evidence IEA]" /GO_process="GO:0006848 - pyruvate transport [Evidence IEA]" /codon_start=1 /gene="mctP" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014674905.1" /locus_tag="IE325_RS10530" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21260" /product="monocarboxylate uptake permease MctP" /protein_id="WP_190069525.1" /transl_table=11 /translation="MNDGVNGVALGVFIFFFLAVTVMGFLAARWRKAENEHSLDEWGLG GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG ENTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG FDEIFAKAGEAYSQTNPATGAPRGALVPAEAGQWTYATLALGSALALFMYPHSITATLS SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFENMFPDWFAG VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKIVSLLVKVGAL VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMIYGTVAAY GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLKAAKAPEGVDETRP EDYTADAGDPGVEAELPPATAGKTH" gene complement(19512..19766) /locus_tag="IE325_RS10535" /old_locus_tag="GCM10018780_21270" CDS complement(19512..19766) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007384611.1" /locus_tag="IE325_RS10535" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21270" /product="DUF3311 domain-containing protein" /protein_id="WP_190069526.1" /transl_table=11 /translation="MSDASEVNRGPVVTPVRVVIALCLVAPFVAMLWVGSYAKTDPAIA GIPFFYWYQMLWVLISTALTMIAYKLWQRDQRGRRGGSK" gene complement(19895..20092) /locus_tag="IE325_RS10540" /old_locus_tag="GCM10018780_21280" CDS complement(19895..20092) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015657905.1" /locus_tag="IE325_RS10540" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_21280" /product="YbdD/YjiX family protein" /protein_id="WP_190069527.1" /transl_table=11 /translation="MRSLRRVLRSVRWYLRELTDESAYDRYVAHVRQGHPDARVPSRRD FERMRTDRQETDPRQGFRCC" ORIGIN 1 ccacgacccg ctcgtaggga tcgtcgtcgt cggcggtacg gcgcagcagc gacgaccgct 61 tctcgatccg cacgatccgc gcgagggtgt ccttcttgcc ggacagatcg ccgacgaggg 121 ccacccggtc gccgaccacc gccgccttgc ggccgagttc gcgggccttc atcgccagca 181 cgatccggtc ctcgacgaga caggtcagcc gcccccggtc gacggtgagg accatgccct 241 cggcggcgtc ctcgtgcttg ggccggatgt tcgtacgggg ccgggtgttg cgtcggccgg 301 gacgggtgcg gatgtcgtcc tcgtcggtgt gcttgccgta gcggcgcatg gcgtgagtcc 361 ctacgccccg agcatcccgg tccacagttc ggggaagtcc ggcagggtct tcgccgtcgt 421 cgccacgttc tcgatgcgta caccctcgac cgcgaggccg atgatcgcgc cggcggtcgc 481 catgcggtgg tcctcgtagg tgtggaagac gccgccgtgc agccggcgcg ggcggatgtg 541 cagaccgtcg gcggtctcgg tgacatcacc gccgagttcg ttgatctcct tggtgagcgc 601 ggccagccgg tccgtctcgt gcagccgcag atgggcgaca ccgcgcaggg tggaggggga 661 gtccgcgacc gccgcgaccg ccgcgatgcc cggggtgagt tcgccgacct cgctcaggtc 721 cacgtcgatg ccgtggaccg cgcccgaacc ggtgaacacc agcccgtact cggtgagttc 781 gcaggagccg cccatctccg tgaagatctc ccgcagccgg tcaccgggct gcgtggtgcg 841 ggccggccag tccgggatga gcaccttgcc gccggtcacc agcgcggcgg ccaggaacgg 901 ctgggcgttc gacagatccg gctcgatcgt cagatcacgg ccgagcaggg cgcccggcgt 961 gacccgccag acgttcggct cgccgcccga ctccggggtg tccacctggg cgccgacggc 1021 acgcagcatg tcgacggtca tccggatgtg cggcatggag ggcagcgagg agccggtgtg 1081 ccggacctcc acaccctggt tgaagcgcgg cccggagagc agcagagcac tcacgaactg 1141 ggacgacgac gaggcgtcga tctccaccgg gccgccctcc agcgcacccc cgccgtgcac 1201 cgtcagcggc agcgcgcccc ggccgtcgtc gtcgatccgc gcaccgaggg cgcgcaaggc 1261 gtcgatcaca ccgtgcaggg ggcgctcgta cgaccggggg tcgccgtcga agcggacggg 1321 accgtcggcc agcgcggcga ccggcggcag gaagcgcatc accgtgccgg cattgccgac 1381 atcgaccgtg gccgggccgc gcagccccgc ggggagcaca cgccacgcct caccggtgcc 1441 ctccgggccg acgccctcct cgatgccgac gcccatggtg cgcagggcgc ccgccatcag 1501 cagggtgtcg cgggagcgga gggggcggcg cagccaaccg ggttccgagg cgagggcggc 1561 gaggacgagg gcacggttgg tgaccgactt ggaccccggc acgtggaccg tcgcgtcgac 1621 gggtccgctc gcttgggggg cgggccagag ggcggggtgt gcggcggggt tttgggccat 1681 gggttcactt tataaggagc gtgtggttcg ggtgcggcgc cgttggggct ggtcgcgcag 1741 ttccccgcgc ccctgaggtg ggctgtcaca cctccagcag ccagcggccg ccacctatca 1801 atgagcagag cgacaccgcg tggaacagga acaaccacag ccccgccggc acatgcgtca 1861 gccgcgacag ctgatccgcg tccgagtccc ccgcccctcc ccgcgcccgc ttcgcctgca 1921 gctcgaacgc cggccgtacc ccgcccacca gcaggaacca caccaccaca tacgcgaacg 1981 ccgcctgcac ctgcggcccc gtgaaccagc tgaccagtac gaacgtgccg cccgtgacga 2041 acacggtcag ggcgccgtac gcgttgcgga tcatgaccag catcgccacc agcaggaccg 2101 tcgccagcca cagcaggagc gtgatgcggc ccgcagccag cagtgcggcg ccgcccaggc 2161 ccagcagcgg gggagcggtg tagcccgcgg ccgcggtgag gatcatgccg atgccgtgcg 2221 gcttgccgcg gctgacggtg aggccgctgg tgtcggagtg cagacgtatg ccggtcaggg 2281 tccggccggt cagcagcgcg atcaggccgt ggccgccctc gtgggcgatg gtgatggcgt 2341 tgcgtgagag gcgccacagg acgtgcggga cgacgaaggc gagtgcgacg accagggcgg 2401 cgatcacgac ccacagatcg gggtcgggct gggtgccgga gacctcgtcc cagagggagg 2461 cgagcgaggc ggatgcggtg ctgtccatgt aaggcgatgg ctccctgtgg tcggctggaa 2521 tctggcagtg tggcacgcat gtgcggacgg tatgcagcga gtcgtaggcc cgaggatctc 2581 gcaggaatct ttgagatcga gacgtgggag ccggaggagt cccttgaggc ggattacaac 2641 gtggctccga ccaaagaggt cctcgtcgtt ctcgaccgtc ccttgaaaga cgtggacgac 2701 cccgcgccgg ttcggcaatt gcgcaagctg aagtggggct tggtgcccag ctggtccaag 2761 actcccgaga gcgccttcaa gatgatcaat gctcgggccg agacggtgca tgagaagccg 2821 tcgtacaagc gggcgttctc ctcccggcgc tgcatcatcc ccgccgacgg ctactacgag 2881 tgggtcaccg gcaagcagga gcgggacctg gaggtcgagg ggaagaagaa gcggccgcgc 2941 aagcagccct acttcgtgct gcccgccgac gggacggtgt tcgcgatggc ggggctgtac 3001 gagttctggc gggacaagac cctgcccgac gagcacccgc aggcctggtg ggtcacctgc 3061 tcggtcatca ccacggaggc cgagacgacc ccgctggccg tcgcgcccga ggaaggcccg 3121 cacacgctcg ccgagatcca cccccggatg ccgctgatgc tgacgccgga ccgctgggac 3181 gcctggctcg acccctcccg caaggacccc gaggaactgc gcaccctcct cgaccctccg 3241 cccgccggac tgatgcgcgc ctaccccgtc tccacgctcg tcagcaacgt ccgcaacaac 3301 ggcccggagc tgctgaagga gctggacggg cccgaagagg gcacactctt ctgatgtgac 3361 gaccgtgacg accgagatca ttggtacgga ggcgggggac gcccgcatca cctggcaccc 3421 ggcgaagaag gccaggctgg tcctcgccgc cagtcatggc gccggcggcg gcatcggggc 3481 ccgggacctt gtggcgctcg ccgaggccct ccccgcccac ggggtgaccg tcgccctcgt 3541 ggagcagccc tggcgcgtgg ccggcaagaa ggtggcgccc gcgccgaaga ccctggacat 3601 cggctggcgg ggcctgtggc ccgcgctcgc cgtacccggg ctgcccgtga tcgcgggcgg 3661 gcgcagcgcg ggggcccgtg tcgcctgccg tacggccgtg gagctcggcg cccatgccgt 3721 gctcgcgctc agcttccccc tgcacccgcc gggcaagccg gagaagtccc gcgccgagga 3781 actgctcggg tccggggtgc cgaccctcgt cgtacagggc gggaacgatc ccttcggcaa 3841 gcccgaggag ttcccggacg gtgacttcga gctggtcgag gtgccctacg gcgaccatgg 3901 cctcgccgtg cccaagcggg cgcccctcga tcaggacgag gccgtggcgc tcgtcacgga 3961 cgcggtgatg aagtgggccg ggtcactcgg gtaaagcttg gggaatgtcg gaggcccggc 4021 cttggttgtg gcggacacag gtgctgaagc accagcgccg acgccgtacg agaggaagtc 4081 cgccgcatgg gttcgaccca ctgccagagc cgcagcagcc gcgccgacct ggactggacg 4141 gtgctgcacg cggccaggac cgccactatt cgaggggcgg cgggtacggc aggtcgtcta 4201 tcctccgatt caggcgggac cggtttcggc cctgcccgga atcttgagga ggtgggtccg 4261 gttcccggta ccgacgcagg gaccgacaac ggccaggcgg agcagcccga gggcctgggc 4321 acgagcgcgg agtcgaccgc ggagcgcagc gcgcgcttcg agcgggacgc gctcgaattc 4381 ctcgaccaga tgtattcggc cgcgctgcgt atgacgcgca acccggccga tgcggaggac 4441 ctggtgcagg agacgtacgc caaggcgtac gcgtcgttcc accagttccg cgagggcacc 4501 aacctcaagg cgtggctgta ccggatcctc accaacacct tcatcaactc ctaccgcaag 4561 aagcagcgtg agccgcagcg ttcggcggcg gaggagatcg aggactggca gctcgcccgc 4621 gccgagtcgc acatgtcgac gggtctgcgc tccgcggagt cgcaggcgct cgaccatctg 4681 ccggactcgg acgtgaagga agcgctccag gccatccccg aggagttccg catcgccgtg 4741 tatctggccg acgtagaggg ctttgcgtac aaggagatcg cggacatcat ggggacaccc 4801 atcggtacgg tgatgtcccg gctgcaccgg ggccgccgtc aactgcgcgg catgctcgag 4861 gactacgccc gcgagcgcgg actggtcccg gccggcgccg gagagtcgaa cgaagcgaaa 4921 ggctcgggct catgagctgc ggagagccgc acgagacgga ctgctccgag gtactcgatc 4981 atctctacga gttcctcgac agcgagatgc cggacgtcga ccgcgacaag ttcaagcagc 5041 acttccagga gtgctcgccg tgcctggaga agtacgggct cgaagaggcc gtgaagaagc 5101 tggtcaagcg gtgctgcgga catgacgacg tgccgaccga cctgcgcgcc aaggttctgg 5161 ggcggctcga tctgatccgc tcgggacagg ccgtgcccga gcacgacgtc acggcgacac 5221 cgcaggaatc ctgaacgcac agtcgtcact cgaacgtgct aatcccccgg tcttaggacc 5281 gcgcacctcc ccctgcccgc cctaggctcc tctgcctgaa gcgcgtggcc tgggaggggc 5341 gtatggaggc gacacccgca ccggcacgtg gctacgtcct ctgtgtcgcc ctcggcgcgc 5401 tgtactgcgt gcacacgctg ccggcggacg ccgtcccctg gtgggcggtg gcgctgctgg 5461 ccgcgctcta cgccgggggc gagcggttgt ccggctcgtt ctatcccgtg ctcctcgccg 5521 gggccttcct gctgccgccg tccgccgccg cgctggtcgc ggtgccgggc gcgctgctcg 5581 ccccggccgg cgggcgcccg cgtctgctgc gccgggtgtg gcgggcggcg cagctcgtgg 5641 tcgtggtgtg ggtggccgcc cgggtgcacg gggaactcgg cgagcacgac gccgtggtgg 5701 ccgccgactt cccgcacgcg ctgctgccgg tcggcgccgc cgtgctggcg ttctgcctgg 5761 ccctgagcct gctggacacc gggatcctgg cgctcgccga gcgcgtaccc ccgtggcgcg 5821 cctggcgtga gcagttcccg cgctccctcg cgccgatcgc cgtgcacggt ctggccggtc 5881 tgatgatggc cgtgctgtgg cgcagcccct acggtcccgt cgccgcgctg ctcgtgctgc 5941 tgccgatgtg cgtgtcgtgg tgggccttcg cccagtacca ccgggagcgc gcggcccatc 6001 aggcgaccat ccgggccctc gtccaggccg tcgacatcaa ggacggctac acccgaggcc 6061 acagcgagcg cgtcggacag gcctccatga tgatcgcccg tgagctgggc ctcgccggcg 6121 aacgcgtcga ggtgctccgc ttcgccggga tcctgcacga cgtcggcaag ctgggcgtgc 6181 ccacgcggct gctgcgcaag aacgggccgc tgacgcccga ggagcggcgg gtgatcgagc 6241 tgcaccccga gtacgggcac gagatggtcc gcgggatctc cttcctcggc gaggcccggg 6301 ccgccgtact gcaccatcac gagcggctgg acggcagcgg ctacccctac gggctgagcg 6361 ggagtcagat cccggagtcg gcacgggtgg tggccgtcgc ggacgccttc gacgccatga 6421 cgtcgacccg gtcctactcg cgggcccggc ccgtctccga ggcgctgcgg gagctggaga 6481 aatgcgcggg ctcacacttc gacccccgga tggtcacggc cctcgccggc gccctcgacc 6541 agcacggctg gcatcccgcg gtgaccgccg acgagcccgc gccgccgacc gccgggcctt 6601 cggccgaccg tgttcccggg gcgcgtcgat gagggccccg ggtgtggcgg ccaagggggt 6661 cgtgtcgatg agcgccccga ggccacccgt cctgctcacc ctgatccacg cctgcgccgc 6721 gctcctcgcc acgggatgtg tgctcggcat cctggccggg ggcctcgccg agcgggccac 6781 ggccctcgcc ttcggggtcc tcatcaccct cggcgagctc acccggtggg ccggggccga 6841 gggcagggag gccgcgccgc tcggtgccgc cgccgcactg tcgtacgccc tgctcggcga 6901 caacggctcg gagcccacac agcacggcgc cgtgcaggtc gtcggagtcg tcctggccgc 6961 ctcgctgctg ggcagcgtgc cgcacatcgc gcgcgggcgc cccgtgctcg accacctcac 7021 ccggcgcgtg ctcaccgtcg gcttcgcggc cgtctgcttc caacccctgt ccaaccaggg 7081 cacgttcgac ggctggggca cctcctacgc gctgctcctg ctggcgatcc tcaccctcac 7141 cgccctgtgc gacgccctgc tcgccgccgc gctggcgcac acgcgcaccc ggtggccctt 7201 cgggccgctg ctgcgggacg agctgcgggc gaccctcggg atcgggtcgg cggtctgcgc 7261 gacgggcgcg gtgatggcgc tggcggtagc cgtgatcggg ctgtgggcgc tgcccgtgtt 7321 ctcggtgccc ctgctgctga cccagctgtc cgtccgccgc tacagcgccg tgcggaccac 7381 ctaccggcag accatcgcct ccctcgcccg cgccaccgag atcgccgggt acaccccggc 7441 cggacacgcc cggcgggtcg ccgcgctcag ccgggacgtg gggcgggacc tgggcctcac 7501 cgaggccgag ctcaccgtgc tggagtacgc ggccctcatg cacgacatcg gtcagctcag 7561 cctcgtcgac ccggtgccgg acggggccac cgccgtgctg cccgtagaga aacagcggcg 7621 gatcgcgctg ctcggagggg ccgtcgtacg gcagaccggc gtgaacccgc aggtcgcgct 7681 ggtcgtggag cggctcgccg acccctgccc cgagcagccg ctgcccgcgc ggatcgtgcg 7741 ggcggtgaac gcctacgagg agatggcgcg cgatgccggg ccgggagggc cgctgaaggc 7801 gctcgaagag ctgcgactgg gtaccgcggg ggagtactcg gcggaggtgg tggaatcgct 7861 ggcccaggtg ctgtccaggg agggtctggc aacgcccttg gctgggtaac ccatgggtaa 7921 tgagcgccct tccagccgta cgtggttgga tgcgaatgag agtgtgtccg ggggcgagca 7981 ctagccagcc cactccacgg aactggcagg cgggaatcgt gaggatcttc ggcaagggac 8041 ggcaccggcc ctccgcctcc tggcggcagg ccaccgaccg ggcgttcacg ctcatcggcg 8101 acggccggta cgaggacgcg ggcgcgctgc tgacacgtgc cgccgatctg gagccctggc 8161 tttcggagtc ctggttcaat ctcgcgctgc tgcacaagtt ccggcacgac tgggagcagg 8221 cccgggccgc cggactgcgt gccgtggcgc tgctcgaccg ggagaccggg gcgcccgact 8281 ggtggaacgt cggcatcgcc gcgaccgcgc tgcaggactg gccgctggcc cggcgggcct 8341 ggcaggcgta cgggctgcgg gtacccggcg gggccaccga ctccggcgag ccggtcggca 8401 tggacctggg cagcgctgcc gtacggctgt ccccggaggg ggaggccgag gtcgtgtggg 8461 ggcgtcgtct cgaccccgcg cggatcgagg tgctgtcgat tccgctgccg tcgtccgggc 8521 ggcgctgggg cgaggtcgtg ctgcacgacg gcgtcccgca cggcgagcgg accacgacgt 8581 ccgggcacgc ctaccccgtc ttcgacgaga tcgagctgtg ggcgccttcg ccggtgccga 8641 cctgggtggt gctgctggag gcggcgaccg aggccgaccg ggacgcgctg gagcagctcg 8701 ccgcggacgc ggggttcgcc gcggaggact ggtcctcgtc ggtgcggctg ctgtgccgga 8761 tgtgttccga gtcgcggatg ccgtccgatg agggggacgg ggagcatctg gatccgcacg 8821 atcacagtga gccggggcat ccggggccgc tcggccatcg gaccgatggg cagctgtggg 8881 tgccggagcg ggagtgcggg gtggctgcgc cggctgcgtt ggtccggggg ctgctggacg 8941 gatgggttgc cgacagtcct gattccaggg attggcggga cttggaagag gtctgctagg 9001 cgccgtaggg gcggggtcgt cggcaggctg cgggctgtgt gtggttgatc gcgcagttcc 9061 ccgcgcccct atcggggcgc tccccgtacc ctgtatcagg attcaccctc tttctttgtg 9121 caggaaggca tacgtcggtc atggcccagc aggacaccga gcagcagcac gcgggcgtgc 9181 tccccgtgga cgacgagggg ttcgtcgtcg acaccgagga cgcggaggag cgcgagaacg 9241 cctggcgtga gcgcggcacc tcgcggccga tcaccgtggt ggggaacccg gttctgcaca 9301 aggagtgcaa ggacgtcacc gagttcggcg ccgagctgga gcagctggtg gcggacatgt 9361 tcgcctcgca gcgcaccgcc gagggcgtgg gcctggccgc caaccagatc ggcgtcgacc 9421 tgaaggtctt cgtctacgac tgccaggacg accagggcga gcggcatgtc ggcgtcgtct 9481 gcaacccgaa gctcgtcgag ctgcccgccg agcagcgccg gctggacgac agcaatgagg 9541 gctgtctgtc ggtgccgacc gcgtacgcgg cgctcgcccg ccccgactac gccgaggtga 9601 ccgggcagga cgagaagggc aacccgatca aggtccgcgg caccggctac ttcgcccggt 9661 gtctgcagca cgagacggac catctgtacg gctacctcta catcgaccgt ctctccaagc 9721 gcgagcgcaa ggacgcgctg cggcagatgg ccgagaacga gccccgctac gccgtggttc 9781 ccaacgactg aggtccactg accgaggtcc tcatacgctc ctggcgctcg gcgcctggtc 9841 aggttcccca cccggccagg cgccgttcgc atgttcgtcg catgttcgat cgcgtacgcg 9901 cgaaatgaag caaatacgtt cccagaacgg tcagttgtgg tgctgaatgg aggtgcgggg 9961 atacgcgact gcacaactgg cggctgagag gagtttgttc gtgcatgctt tctcggacag 10021 caccacagcg acatcgacgg cggtccaggt tccaccgtcg ctctctctcc cggtgatcga 10081 agcggcgttt cccaggcgac ttcatcccta ttggccccgg ctccaggaca agacccgggc 10141 ctggttgctc cagaagcgac tgatgccggc cgacaaggtc gaggaatatg ccgacggcct 10201 gtgctacacc gacctcatgg ccgggtacta cataggcgcc ccggacgatg tcctccaggc 10261 gatcgcggac tacagcgcgt ggttcttcgt ctgggacgac cggcacgacc gggacatcgt 10321 ccaccgccgc ccggcggcct ggcggcggct gagattccgg ctgcacacgg cgctcgactc 10381 ccccgaggac catctgcacc acgaggatcc gctggtggcg gcgttcgcgg acagcgtggg 10441 acggctgttc tcgttcctgc ccggcacctg gaacgcgcgg ttcgcccggc acttccacgc 10501 cgtgatcgag gcgtacgacc aggaattcca caaccgaatg gaagggaagg tccccaccgt 10561 cgaggaatac ctcgaactgc gccggctcac cttcgcacac tcgatctgga ccgatctgct 10621 ggagccgagc gtcggaatgg aacttccgga atccgtgcgc aaatatccgg catatcgacg 10681 ggcggcactg ctgagccagg aattcgccgc ctggtacaac gatctctgct cattcccgaa 10741 ggaaatagcg ggcgacgagg tccacaatct cggtatcagt ctcatcaccc acaaggggct 10801 gactctcgaa gagacgatcg cggaagtcag acgacgcgtc gaggactgca tctccgattt 10861 cctggtggcc gagcgcgagg ccctggaatt cgccggcctg ctggccgacg gcacaccgcg 10921 gggcgcggaa ctcggcaccg ccgtgcgcgc ctgcgtcggc aatatgcgca actggttcag 10981 ctcggtctac tggttccacc acgagtccgg ccgttaccgc gtcgacagct gggacgaccg 11041 gtccacaccc ccgtacgtca acaacgaagc ggcaggtgag ctatgaccac ggtcctggaa 11101 ctgcgtgaac cgcccctcgc cggcggggga gtcccgctgc tgggccacgg ctggaggatg 11161 gtccgcgatc cgctggcctt cgtggcggcg ctgcgcgacc acggcgacgt cgtacggatc 11221 aaactggggc cgaagacggt gtacgccgtc accacacccg acctcaccgg cgcgctcgcg 11281 ctgagcaccg acttcgagat cgccgggccg ctgtgggagt ccctggagag cctgctcggc 11341 aaggagggcg tggccaccgc caatgggccc cggcaccggc ggcagcggcg caccatccag 11401 cccgccttcc ggctcgacgc catccccggg tacgggccga tcatggccga ggaggcgcat 11461 gcgctgaccg agcgctggcg gcccggcgag accgtcgact gcaccgccga gtccttccgg 11521 atcgccgtgc ggatcgtggc ccgctgtctg ctgcgcggcg cgtacatgga cgagcgggcc 11581 gaccggctgt gcgccgccct cgacaccctg ttccgcggca tgtaccggcg gatggtgatc 11641 cccctcgggc cgctctacga cctgccgctc ccggccaacc gccgattcaa tggcgccctg 11701 gccgattttc atctcctggt cgacgaggtc atcgccgaac gcagggcatc cggtcaaaag 11761 ccggacgatt tgctgacggc attgctgcac gcgaaggacg agaatggtga ccccatcggg 11821 gagcaggaga tccatgacca ggtcgtcgcg atattcaccg ccggcaccga aacggtggcg 11881 tccacgatct tgtggctgct ccatgtgctc gcggaacatc cggaacacgc cgacaaggta 11941 agcgcagagg tcgaatccgt caccggcggt cgccccgtgg cattcgagga cgtccgtgcg 12001 ctgcggcaca ccaacaatgt cgtcgtggaa gcgatccgtt tgcgccccgc gatctggatt 12061 ctgacgcgcc gggcggtggc cgacacatca ctcggtggct atcgcattcc ggccggagcc 12121 gacatcgtct acagccccta cgccgtccag cgcgatccga agtcgtacgt gcgccacctc 12181 gacttcgacc ccgaccgctg gcttcccgag cgcgtcaagg aggtgccgaa atacgccatg 12241 agccccttcg gggtcggcaa ccgcaagtgc ccgagcgacc acttctccat ggcgatgctg 12301 tcgctgatca cggcggccct ggccggccgg taccgcttcg agcaggcgtc cggctcgaac 12361 gactcgaccc gggtggggat caccctgcat ccgcacaccc tgctgctgac gccggtcgag 12421 cgggagtagc tcaggccgcc tcggggccct ggaacgtccg ccggtaggcg ttcggtgtcg 12481 tccccagcgt ccgtacgaac tgatggcgca gcgcggccgc ggtgccgaac ccggtccggc 12541 ccgcgatcgc gtccacggtc tcgtccgtcg cctccagcaa ccgctgggcc agcagcacac 12601 gttggcgcag gatccagcgg tagggagtcg tgccggtctc ctgctggaag cggcgggcga 12661 aggtgcgcgg tgacatgagc gcgcgctcgg cgagctgctc gacggtgacg tcctcgtcga 12721 ggtggcgctc catccaggcc agcacctcgc cgacagtgtc gcactgggag cgcggcagcg 12781 ggcgctcgat gtactgggcc tgtccgccgt cccggtgcgg cggcaccacc atgcgccggg 12841 cgatcttgtt ggcgacctcg ggcccctgct cctggcgcac gatgtgcaga caggcgtcga 12901 tcccggcggc ggtgccggcg ctggtgatca ccgggccctc gtcgacgtac agcacatcgg 12961 gctcgacgat cgcccgcggg tgctgtcggg tcagttcccc ggcgtgcttc cagtgcgcac 13021 tgcaccgccg cccgtcgagc agcccggccg cgcccagcac gaagacgccg gagcacacgc 13081 tgagcacccg cgcgccccgc tcgaccgctc tgaccaggga gtccaacagc tcgggcggat 13141 agtcgcgcac gacatagtcg ctgcccgcgg gcaccgcgat caggtcggcc tcctcaagcc 13201 gctccagacc gtagggcgtg gagacggaga gtccgccgac atgggtgccc agcgtcggcc 13261 cctccgccga tacgacggcg aagtcgtacg tgggcagccc ctcgtcactg cggtcgatgc 13321 cgaacacctc gcagacgacg ccgagttcga agggatgcac gccgttgagc aggacggccg 13381 ccacgttctt cagcatgctg ccagtgtgcc tcggaagtgg cagtaaatcg agggtgtacg 13441 gcagtcctgc cactgtcagg agtgtcttgc cggtatgaga cttacctcat gaacgcaatc 13501 ctcgaatacg tcgccgtagt gattctcttc ctgatcctcg cgggtccggc gctcgtggga 13561 catctccacg agcgccggat cgaccgccag ctgaaggcgg tggaatccaa gaagactcag 13621 aagtcctcgt ccaggtcgac ggtgccctcc accgccacct ggtacgccga gggacgccgc 13681 tcgaagaagt tggtgagctc ctgaacaccc tgcagctcca tgaagctgaa ggggttctcg 13741 gagccgtaca ccggagcgaa gccgaggcgc gtcaggcgct gatcggcgac acactccagg 13801 tactgccgca tcgagtcggt gttcatgccc gggaggccgt caccgcacag gtcgcgcgcg 13861 aactgcagct cggcctcgac ggcctccctc agcatgtcgg tgacttcctg ctggagctgg 13921 tcgtcgaaga gctccggctc ctccttgcgg acggtgtcga ccacatcgaa ggcgaacgac 13981 atgtgcatcg tctcgtcgcg gaacacccag ttggtgccgg tggccagacc gtgcagcagg 14041 ccccggctgc ggaaccagta gacgtaggcg aaggcaccgt agaagaacag gccctcgatg 14101 cacgcggcga agcagatcag gttcagcagg aagcgacgcc ggtcggcctg ggtctgcagg 14161 ctctccagct tctcgacctc gttgatccac ttgaagcaga actcggcctt ctcgcggatc 14221 gaggggatgt tctcgacggc gtcgaaggcg gccgccctgt cctccgggtc ggggaggtag 14281 gtgtcaagga gcgtcagata gaactggacg tgcacggcct cctcgaagag ctggcgcgac 14341 aggtacaggc gcgcctccgg ggagttgatg tgcttgtaca gcgtcagcac caggttgttc 14401 gccacgatcg agtcgcccgt cgcgaagaac gcgaccagcc ggccgatcat gtgctgctca 14461 ccctcggaca gcttggcgag atcggcgacg tccgagtgga ggtcgacctc ctccacggtc 14521 caggtgttct tgatggcgtc ccggtagcgc tcgtagaagt ccgggtagcg catggggcgc 14581 agggtcagct cgaagcccgg gtcgaggaga ttggcgttac gggtactcat tactggcagg 14641 cctcgcagga ctcggggttt tccagggagc aggcgacggc gtcttcgggc gccggctgct 14701 gggcggggat ggcggcttgg gcctgggcgg cgcgggcgat gcgggtcgcc gggcgcgagc 14761 gcaggtagta cgtcgtcttc aggcccgact tccaggcgta cgcgtacatc gaggagagct 14821 tgccgatggt cggcgtctcc aggaacaggt tcagggactg cgactggtcc aggaacgggg 14881 tccgggcggc ggccatgtcg atgagcccgc gctgcgggat ctcccacgcc gtgcggtaca 14941 gcgcccgtac gtccgccggg atccaggcga agtcctgcac cgagccgttc gattcgcgca 15001 gcgcctcacg ggtgcgggcg tcccacacgc cgagcgcctt cagctcgtcg accaggtagg 15061 agttgacctg gaggaactca ccggagagcg tctcgcgctt gaacaggttg gagacctgcg 15121 gctcgatgca ctcgtagaca ccggcgatgg acgcgatggt ggcggtgggc gcgatggcga 15181 gcagcaggga gttgcgcaga ccggtggtgg cgatacggcc gcgcagggcc gcccagcgct 15241 ccggccaggt cagctcggcg tccgggtagt ggtcggggtg caggacgccc tgggcggtac 15301 gggtcttctc ccaggcaggc agcgggccgc tgcgctcggc gaggtcggcg gacgcctcgt 15361 acgcggcgag catgatgcgc tcggcgatcc gcgtggagag cgccttcgcc tcgggcgagt 15421 cgaagggcag ccgcagcttg aagaacacgt cctgcagacc catcgcgccg aggcccaccg 15481 gccgccactt ggcgttggag cggcccgcct gctcggtcgg gtagaagttg atgtcgacga 15541 cacggtccag gaaggtgacg gcggtgcgga cggtggcgtc gaggcgctcc cagtcgatgt 15601 ccccgttgtc cacgaacgcg ccgaggttga ccgagcccag gttgcagacc gccgtctccc 15661 cgtcgtcggt gacctccagg atctccgtgc agaggttgga cgagtggacg acatggcccg 15721 gcagcgccgt ctggttggcg gtgcggttgg cggcgtcctt gaacgtcatc cagccgttgc 15781 cggtctgcgc gagggtgcgc atcatacggc cgtacagatc acgcgccggg atggtcttct 15841 tggcgagccc ggcggcctcg gccttgcggt aggccgcgtc gaactcctcg ccgtgcagat 15901 cgaccagctc gggcacgtcg gcgggggaga acagcgacca tacggcgtcc gcgttcaccc 15961 ggcgcatgaa ctcgtccggg atccagtgcg cgaggttcag attgtgcgta cggcgggcgt 16021 cctcaccggt gttgtcgcgc agctccagga actcctcgat gtcggagtgc caggtctcca 16081 ggtacaccgc ggcggccccc ttgcgccggc cgccctggtt caccgcggcg acggaggcgt 16141 cgagggtctt caggaacggg acgatgccgt tggagtgccc gttggtgccg cggatcagcg 16201 aaccgcggct gcggatgcgg gagtacgcga tgccgatacc gccggcgtgc ttcgagagcc 16261 gggcgacctg gtggtagcgg tcgtagatgg agtccagctc gtcgagcggg gagtccagga 16321 ggtagcagga cgacatctgg gggtgccggg tgccggagtt gaacagggtg ggggaggagg 16381 ggaggtagtc gaggcggctc atgagcccgt agagcgcggc gacttcgtcc agtgcgcgga 16441 cactgtcgtc ctcggcgaga ccggcggcga cccggagcat gaagtactgc ggagtctcga 16501 tcacgcgacg ggtgatcggg tgccggagca ggtaccggct gtgcagggtg cgcaggccga 16561 agtagccgaa gcggtcgtcg gcgccggtgt cgaccagggc gtcgagacgg gccgcgtgga 16621 tccgcgcgaa ctccgcggtg cggtcggcga tgaggccctc gcggtggccg acggcgaccg 16681 acccggtgaa ggacgtgacg ccctgcgagg cggcctcggc ggcgatggag agggtcagca 16741 gcctggccgc cagcctgctg taggcggggt cctcggagat gagaccggcg gccgcctcgg 16801 tggccagctc gcgcagctcc gcctcgtccg cgcgcgcgga ccggccccgc agcgcggcgg 16861 cggcgacccg gccggggtcg gcgtcgagga ggtcggcggt cagctcggtg agggtccgca 16921 gcagtgcggt accgggaccg tcggtcttca gctcggtgac tgaaaccggg tcggctggcg 16981 cgatggtcac gtgggggctc tccctcgctc ggcacggggc ctcgccgagg gcagggggcg 17041 gtacacgagc gcacggggcg tcgcgtccac cggcccattc cacgaggccc ggacgtcagg 17101 gcgcaccggc cgggtggccg ggcgcgctgt cggcaggtcc tcggactgac tctcatatgt 17161 gtgcgaacac gcatgagtac accgttgcgg gacagttccg gattcgcacc ggattcccct 17221 gcgacgacag cgagcacgag catacatctt gtgccgggct gtcgtatcac ccccagatgt 17281 tgtgtcgcgc tggtttcaga gcgtcaactc gtaggtgaga agagtgatgt cgtcgaggtg 17341 cgggatcgga ttccagtccc gctccggtgt gcggacgaag cccagccgtt catagatgcg 17401 gtgggctccg tgcatggtgc gctgggtcga caggacgatc ctcgcgcagc cctcggtggc 17461 ccgcgcccga tcgacgcagg cgcggacgag ggcctcgccg gcgccacggc cccgtccgtc 17521 gtgcgcgacc gccagcatgc ggatctccgc ctccgagggg cgggctatgt cggccatggg 17581 gccgccggac gggacgaagg tcacgccgcc cagcagccgg ccgttctcga cggccaccag 17641 cacctcggcg gcggccgcgc gccccgccac gtccttcagt tcgctcaggt attcgtcgct 17701 ctcgccgaag tcgaggaggc cgtcctggag ataggcccgg gcggtgatct caccgagggg 17761 ctcgtactcg ccgggttccg cccgccggat cacgatgtcc atggggccga gtctgccgga 17821 cgcgacgagc ggcgggccgc cggatttctc cgnnnnnnnn nnnnnnnnng tatcgctcgg 17881 tatcgctcag tgggtcttgc ccgcggtcgc cggaggcagt tccgcctcga cgcccgggtc 17941 gcccgcgtcc gccgtgtagt cctccggcct ggtctcgtcc acgccctccg gggccttcgc 18001 ggccttcagg acgaaggtga ggaccaccgt gaccaccacg ttcagcacga acgccgtgag 18061 gccgatgtag ccgatctcgc cgatgcccgg gatctccttc gccgacccgc cgaagtgctt 18121 ctgggtcggg gaggcgacgc cgtacgcggc gaccgtgccg tagatcatgc cgaccgccca 18181 gccggccagc agggcccagc ggtggaacca gcgggtgaac aggccgccga ccagggccgg 18241 gaaggtctgc aggatccaga tgccgcccag cagctggaag ttgatggcga ccgtcttgtc 18301 catggtcagg acgaagacca gtgcgccgac cttcaccagc agggacacga tcttggagac 18361 cttggtctcc tgcgcgggcg tcgcgtccgg cttgatgaag tccttgtaga tgttgcgggt 18421 gaagagattc gcggccgcga tggacatgat ggccgccggc acgagggcgc cgatgccgat 18481 cgctgcgaag gccacgcccg cgaaccagtc cgggaacatg ttctcgaaca gctgcgggat 18541 cgccagctgg ccgttctgca ccttgatgcc ggccgcgatc gccatgaagc ccagcagcgc 18601 cagcaggccc agcatcaggg agtacagcgg caggatcgtg gtgttgcggc ggatcacctc 18661 acggctgcgc gaggacagcg tcgcggtgat cgagtgcggg tacatgaaca gcgcgagcgc 18721 ggagcccagc gccagcgtgg cgtacgtcca ctgcccggcc tcggccggca ccagcgcacc 18781 gcgcggcgcg cccgtcgccg ggttggtctg gctgtacgcc tcgcccgcct tggcgaagat 18841 ctcgtcgaag ccgcccagct tgatcgggat gtagatgatc gccaccgcga tgacgatgta 18901 gatcagcgtg tccttcacga acgcgatcag cgcgggggcg cgcagaccgg acgagtaggt 18961 gtacgcggcc agcacaccga aggcgatgag cagcggcagg tccttgatga accagttggt 19021 gttctcgccg ccgccgacgc ccatcacgtc gagcacggcc tggatgccga cgagctggag 19081 cgcgatgtac ggcatcgtcg ccaggatgcc ggtgaccgcg acggccagcg acaggccctt 19141 ggagccgaag cggccgcgca cgaagtccga ggtcgtcaca tagccgtgct tgtgggacac 19201 cgaccacagg cggggcagga acgtgaagat caacgggtag acgaggatcg tgtacggcac 19261 cgcgaagaag cccgccgccc cggccgcgta gatcgccgcc gggaccgcca cgaacgtata 19321 cgccgtgtac aggtcgccgc cgagcaggaa ccaggtgacc caggtgccga acgaccgtcc 19381 gcccaggccc cattcgtcga ggctgtgctc gttctcggcc ttgcgccagc gcgcggccag 19441 gaagcccatg accgtgacgg ccaggaagaa gaagatgaag acgccgagcg cgacgccgtt 19501 cacgccgtcg ttcacttgct acctccacgg cgtccgcgct ggtcacgctg ccacaacttg 19561 tacgcgatca tcgtcagcgc ggtggagatc agcacccaga gcatctggta ccagtagaag 19621 aacgggatac cggcgatcgc cgggtcggtc ttggcgtacg agccgaccca cagcatcgcc 19681 acgaagggcg cgacgagaca gagcgcgatg acgacccgta cgggcgtcac caccggccct 19741 ctgttcactt ccgaggcatc tgacatctga cggctccgtc ccctcactga tcacctgaga 19801 aacgcccggg caatgtaggt gacggtgcaa cgacagcgga agaccctgtc cgcatatcgg 19861 atgtggagga ttggtgtagg cggcaacggc atgctcagca gcagcggaac ccctggcgcg 19921 ggtcggtctc ctgacggtcc gtccgcatcc gttcgaagtc acgccgggag ggcacccggg 19981 cgtccggatg cccttgccgt acatgcgcga catagcggtc gtacgccgat tcgtcggtca 20041 gctcccgcag ataccagcgg acgctacgga gtacgcgccg aagcgagcgc atcgcgctcc 20101 tcctccttct cctccttggt cgggatcagc cccgccggag cgatgatctt cgactcgaca 20161 tacggcgcct cgctcagcgt ggacagcgcc gggcggcgga tgtgccggac gcagacgcgg 20221 gtggcgtcgg cgatcacgac gacgatcagg atcgcgaggg ccgcggtgag gacgccgtcc 20281 accgtggagt tggtgaccac ggtgtgcatg tcgtccatgg acttggcggg cggcaggacc 20341 tcgccgcggt cgatggcgtc ctggaagacc tggcgctgct tgaagaagcc gaccttgggg 20401 tcgctggaga acaccttctg ccagctggcg gtcagggtga ccgtcgcgtc ccagaccagc 20461 ggaaccccgg tgatccaggc ccacttgagg cgcccggact tcaccagcag ggtcgtgcag 20521 acggcgaggg cgacggccgc gagcaactgg ttggagatgc cgaagatcgg gaagagctgg 20581 ttgatgccgc cgaggggttc gtggacgccg acccacagga agtagcccca gaggccgcac 20641 acgatggcgc tggtgatggc cagacccggc ttccaactga cgttcttgaa gggccggtag 20701 acgttgccca gcatgtcctg gagcatgaac cggcccaccc gggtgccggc gtccagcgcg 20761 gtcaggatga acagcgcctc gaacatgatg gcgaagtggt accagaaggc acgcaggccg 20821 cccccggtga cctgcgagaa gatctccgag acgccgatgg cgagggtcgg cgcaccgccg 20881 gtccgggaga gcagcgacgc ctcctcgacg ttctccgccg cccgcgcgag cgcctccggg 20941 gagatctggt aaccccaact gcccaccacc tgcgaggcgt tctgcaccgt gtcgccgatg 21001 accccggcgg gcgcgttcat cgcgaagtac aggcccgggt cgatgatgct cgccgcgacc 21061 agcgccatca cggcgaccga cgactc //