LOCUS       NZ_BNBM01000003        21086 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000003
VERSION     NZ_BNBM01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 687919)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 325816
            Orig. end                         :: 346902
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(361..1680)
                     /gene="aroA"
                     /locus_tag="IE325_RS10450"
                     /old_locus_tag="GCM10018780_21090"
     CDS             complement(361..1680)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522882.1"
                     /locus_tag="IE325_RS10450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21090"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_190069510.1"
                     /transl_table=11
                     /translation="MAQNPAAHPALWPAPQASGPVDATVHVPGSKSVTNRALVLAALAS
                     EPGWLRRPLRSRDTLLMAGALRTMGVGIEEGVGPEGTGEAWRVLPAGLRGPATVDVGNA
                     GTVMRFLPPVAALADGPVRFDGDPRSYERPLHGVIDALRALGARIDDDGRGALPLTVHG
                     GGALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSSLPSMPHIRMTVDMLRAV
                     GAQVDTPESGGEPNVWRVTPGALLGRDLTIEPDLSNAQPFLAAALVTGGKVLIPDWPAR
                     TTQPGDRLREIFTEMGGSCELTEYGLVFTGSGAVHGIDVDLSEVGELTPGIAAVAAVAD
                     SPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYEDHR
                     MATAGAIIGLAVEGVRIENVATTAKTLPDFPELWTGMLGA"
     gene            complement(1766..2488)
                     /locus_tag="IE325_RS10455"
                     /old_locus_tag="GCM10018780_21100"
     CDS             complement(1766..2488)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998067.1"
                     /locus_tag="IE325_RS10455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21100"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_190069511.1"
                     /transl_table=11
                     /translation="MDSTASASLASLWDEVSGTQPDPDLWVVIAALVVALAFVVPHVLW
                     RLSRNAITIAHEGGHGLIALLTGRTLTGIRLHSDTSGLTVSRGKPHGIGMILTAAAGYT
                     APPLLGLGGAALLAAGRITLLLWLATVLLVAMLVMIRNAYGALTVFVTGGTFVLVSWFT
                     GPQVQAAFAYVVVWFLLVGGVRPAFELQAKRARGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSLCSLIGGGRWLLEV"
     gene            2539..3354
                     /locus_tag="IE325_RS10460"
                     /old_locus_tag="GCM10018780_21110"
     CDS             2539..3354
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="IE325_RS10460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21110"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_190069512.1"
                     /transl_table=11
                     /translation="MCGRYAASRRPEDLAGIFEIETWEPEESLEADYNVAPTKEVLVVL
                     DRPLKDVDDPAPVRQLRKLKWGLVPSWSKTPESAFKMINARAETVHEKPSYKRAFSSRR
                     CIIPADGYYEWVTGKQERDLEVEGKKKRPRKQPYFVLPADGTVFAMAGLYEFWRDKTLP
                     DEHPQAWWVTCSVITTEAETTPLAVAPEEGPHTLAEIHPRMPLMLTPDRWDAWLDPSRK
                     DPEELRTLLDPPPAGLMRAYPVSTLVSNVRNNGPELLKELDGPEEGTLF"
     gene            3365..3994
                     /locus_tag="IE325_RS10465"
                     /old_locus_tag="GCM10018780_21120"
     CDS             3365..3994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998051.1"
                     /locus_tag="IE325_RS10465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21120"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_190069802.1"
                     /transl_table=11
                     /translation="MTTEIIGTEAGDARITWHPAKKARLVLAASHGAGGGIGARDLVAL
                     AEALPAHGVTVALVEQPWRVAGKKVAPAPKTLDIGWRGLWPALAVPGLPVIAGGRSAGA
                     RVACRTAVELGAHAVLALSFPLHPPGKPEKSRAEELLGSGVPTLVVQGGNDPFGKPEEF
                     PDGDFELVEVPYGDHGLAVPKRAPLDQDEAVALVTDAVMKWAGSLG"
     gene            4252..4935
                     /gene="sigR"
                     /locus_tag="IE325_RS10470"
                     /old_locus_tag="GCM10018780_21130"
     CDS             4252..4935
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="IE325_RS10470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21130"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_190069513.1"
                     /transl_table=11
                     /translation="MGPVPGTDAGTDNGQAEQPEGLGTSAESTAERSARFERDALEFLD
                     QMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKK
                     QREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEFRIAV
                     YLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGESNEA
                     KGSGS"
     gene            4932..5234
                     /gene="rsrA"
                     /locus_tag="IE325_RS10475"
                     /old_locus_tag="GCM10018780_21140"
     CDS             4932..5234
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="IE325_RS10475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21140"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_190069514.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFKQHFQECSPCL
                     EKYGLEEAVKKLVKRCCGHDDVPTDLRAKVLGRLDLIRSGQAVPEHDVTATPQES"
     gene            5343..6632
                     /locus_tag="IE325_RS10480"
                     /old_locus_tag="GCM10018780_21150"
     CDS             5343..6632
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491202.1"
                     /locus_tag="IE325_RS10480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21150"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_190069515.1"
                     /transl_table=11
                     /translation="MEATPAPARGYVLCVALGALYCVHTLPADAVPWWAVALLAALYAG
                     GERLSGSFYPVLLAGAFLLPPSAAALVAVPGALLAPAGGRPRLLRRVWRAAQLVVVVWV
                     AARVHGELGEHDAVVAADFPHALLPVGAAVLAFCLALSLLDTGILALAERVPPWRAWRE
                     QFPRSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWAFAQYHRERAAHQAT
                     IRALVQAVDIKDGYTRGHSERVGQASMMIARELGLAGERVEVLRFAGILHDVGKLGVPT
                     RLLRKNGPLTPEERRVIELHPEYGHEMVRGISFLGEARAAVLHHHERLDGSGYPYGLSG
                     SQIPESARVVAVADAFDAMTSTRSYSRARPVSEALRELEKCAGSHFDPRMVTALAGALD
                     QHGWHPAVTADEPAPPTAGPSADRVPGARR"
     gene            6668..7909
                     /locus_tag="IE325_RS10485"
                     /old_locus_tag="GCM10018780_21160"
     CDS             6668..7909
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998047.1"
                     /locus_tag="IE325_RS10485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21160"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_190069516.1"
                     /transl_table=11
                     /translation="MSAPRPPVLLTLIHACAALLATGCVLGILAGGLAERATALAFGVL
                     ITLGELTRWAGAEGREAAPLGAAAALSYALLGDNGSEPTQHGAVQVVGVVLAASLLGSV
                     PHIARGRPVLDHLTRRVLTVGFAAVCFQPLSNQGTFDGWGTSYALLLLAILTLTALCDA
                     LLAAALAHTRTRWPFGPLLRDELRATLGIGSAVCATGAVMALAVAVIGLWALPVFSVPL
                     LLTQLSVRRYSAVRTTYRQTIASLARATEIAGYTPAGHARRVAALSRDVGRDLGLTEAE
                     LTVLEYAALMHDIGQLSLVDPVPDGATAVLPVEKQRRIALLGGAVVRQTGVNPQVALVV
                     ERLADPCPEQPLPARIVRAVNAYEEMARDAGPGGPLKALEELRLGTAGEYSAEVVESLA
                     QVLSREGLATPLAG"
     gene            8019..8999
                     /locus_tag="IE325_RS10490"
                     /old_locus_tag="GCM10018780_21170"
     CDS             8019..8999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="IE325_RS10490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21170"
                     /product="hypothetical protein"
                     /protein_id="WP_190069517.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLRVPGGATDSGEPVGMDLGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTTSGHAYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPAALVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9141..9791
                     /gene="def"
                     /locus_tag="IE325_RS10495"
                     /old_locus_tag="GCM10018780_21180"
     CDS             9141..9791
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="IE325_RS10495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21180"
                     /product="peptide deformylase"
                     /protein_id="WP_190069518.1"
                     /transl_table=11
                     /translation="MAQQDTEQQHAGVLPVDDEGFVVDTEDAEERENAWRERGTSRPIT
                     VVGNPVLHKECKDVTEFGAELEQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD
                     QGERHVGVVCNPKLVELPAEQRRLDDSNEGCLSVPTAYAALARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYAVVPND"
     gene            10001..11086
                     /gene="cyc1"
                     /locus_tag="IE325_RS10500"
                     /old_locus_tag="GCM10018780_21190"
     CDS             10001..11086
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190552.1"
                     /locus_tag="IE325_RS10500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21190"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_190069519.1"
                     /sec_met_domain="T1TS (E-value: 2.5e-61, bitscore: 203.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFSDSTTATSTAVQVPPSLSLPVIEAAFPRRLHPYWPRLQDKT
                     RAWLLQKRLMPADKVEEYADGLCYTDLMAGYYIGAPDDVLQAIADYSAWFFVWDDRHDR
                     DIVHRRPAAWRRLRFRLHTALDSPEDHLHHEDPLVAAFADSVGRLFSFLPGTWNARFAR
                     HFHAVIEAYDQEFHNRMEGKVPTVEEYLELRRLTFAHSIWTDLLEPSVGMELPESVRKY
                     PAYRRAALLSQEFAAWYNDLCSFPKEIAGDEVHNLGISLITHKGLTLEETIAEVRRRVE
                     DCISDFLVAEREALEFAGLLADGTPRGAELGTAVRACVGNMRNWFSSVYWFHHESGRYR
                     VDSWDDRSTPPYVNNEAAGEL"
     gene            11083..12429
                     /locus_tag="IE325_RS10505"
                     /old_locus_tag="GCM10018780_21200"
     CDS             11083..12429
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058302.1"
                     /locus_tag="IE325_RS10505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21200"
                     /product="cytochrome P450"
                     /protein_id="WP_190069520.1"
                     /sec_met_domain="p450 (E-value: 5.8e-71, bitscore: 234.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVLELREPPLAGGGVPLLGHGWRMVRDPLAFVAALRDHGDVVR
                     IKLGPKTVYAVTTPDLTGALALSTDFEIAGPLWESLESLLGKEGVATANGPRHRRQRRT
                     IQPAFRLDAIPGYGPIMAEEAHALTERWRPGETVDCTAESFRIAVRIVARCLLRGAYMD
                     ERADRLCAALDTLFRGMYRRMVIPLGPLYDLPLPANRRFNGALADFHLLVDEVIAERRA
                     SGQKPDDLLTALLHAKDENGDPIGEQEIHDQVVAIFTAGTETVASTILWLLHVLAEHPE
                     HADKVSAEVESVTGGRPVAFEDVRALRHTNNVVVEAIRLRPAIWILTRRAVADTSLGGY
                     RIPAGADIVYSPYAVQRDPKSYVRHLDFDPDRWLPERVKEVPKYAMSPFGVGNRKCPSD
                     HFSMAMLSLITAALAGRYRFEQASGSNDSTRVGITLHPHTLLLTPVERE"
     gene            complement(12431..13396)
                     /locus_tag="IE325_RS10510"
                     /old_locus_tag="GCM10018780_21210"
     CDS             complement(12431..13396)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998042.1"
                     /locus_tag="IE325_RS10510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21210"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_190069521.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLNGVHPFELGVVCEVFGIDRSDEGLPTYDFAVVSAE
                     GPTLGTHVGGLSVSTPYGLERLEEADLIAVPAGSDYVVRDYPPELLDSLVRAVERGARV
                     LSVCSGVFVLGAAGLLDGRRCSAHWKHAGELTRQHPRAIVEPDVLYVDEGPVITSAGTA
                     AGIDACLHIVRQEQGPEVANKIARRMVVPPHRDGGQAQYIERPLPRSQCDTVGEVLAWM
                     ERHLDEDVTVEQLAERALMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETV
                     DAIAGRTGFGTAAALRHQFVRTLGTTPNAYRRTFQGPEAA"
     gene            complement(13617..14630)
                     /locus_tag="IE325_RS10515"
                     /old_locus_tag="GCM10018780_21230"
     CDS             complement(13617..14630)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="IE325_RS10515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21230"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_190069522.1"
                     /transl_table=11
                     /translation="MSTRNANLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLAKLSEGEQHMIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPEDRAAAFDAVENIPSIREKAEFCFKWINEVEKLESLQTQAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPELFDDQLQQEVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14630..16990)
                     /locus_tag="IE325_RS10520"
                     /old_locus_tag="GCM10018780_21240"
     CDS             complement(14630..16990)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657909.1"
                     /locus_tag="IE325_RS10520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21240"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_190069523.1"
                     /transl_table=11
                     /translation="MTIAPADPVSVTELKTDGPGTALLRTLTELTADLLDADPGRVAAA
                     ALRGRSARADEAELRELATEAAAGLISEDPAYSRLAARLLTLSIAAEAASQGVTSFTGS
                     VAVGHREGLIADRTAEFARIHAARLDALVDTGADDRFGYFGLRTLHSRYLLRHPITRRV
                     IETPQYFMLRVAAGLAEDDSVRALDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPLDELDSIYDRYHQVARLSKHAGGIGIAYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE
                     FMRRVNADAVWSLFSPADVPELVDLHGEEFDAAYRKAEAAGLAKKTIPARDLYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTALPGHVVHSSNLCTEILEVTDDGETAVCNLGSVNLGA
                     FVDNGDIDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVFF
                     KLRLPFDSPEAKALSTRIAERIMLAAYEASADLAERSGPLPAWEKTRTAQGVLHPDHYP
                     DAELTWPERWAALRGRIATTGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETL
                     SGEFLQVNSYLVDELKALGVWDARTREALRESNGSVQDFAWIPADVRALYRTAWEIPQR
                     GLIDMAAARTPFLDQSQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIAR
                     AAQAQAAIPAQQPAPEDAVACSLENPESCEACQ"
     regulatory      complement(17114..17260)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17240..17254)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 24.21"
                     /tool="antismash"
     misc_feature    complement(17271..17285)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17296..17802)
                     /locus_tag="IE325_RS10525"
                     /old_locus_tag="GCM10018780_21250"
     CDS             complement(17296..17802)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019326961.1"
                     /locus_tag="IE325_RS10525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21250"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190069524.1"
                     /transl_table=11
                     /translation="MDIVIRRAEPGEYEPLGEITARAYLQDGLLDFGESDEYLSELKDV
                     AGRAAAAEVLVAVENGRLLGGVTFVPSGGPMADIARPSEAEIRMLAVAHDGRGRGAGEA
                     LVRACVDRARATEGCARIVLSTQRTMHGAHRIYERLGFVRTPERDWNPIPHLDDITLLT
                     YELTL"
     assembly_gap    17853..17869
                     /estimated_length=17
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(17887..19515)
                     /gene="mctP"
                     /locus_tag="IE325_RS10530"
                     /old_locus_tag="GCM10018780_21260"
     CDS             complement(17887..19515)
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="IE325_RS10530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21260"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_190069525.1"
                     /transl_table=11
                     /translation="MNDGVNGVALGVFIFFFLAVTVMGFLAARWRKAENEHSLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGAAGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFIKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFAKAGEAYSQTNPATGAPRGALVPAEAGQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGIKVQNGQLAIPQLFENMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPAQETKVSKIVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMIYGTVAAY
                     GVASPTQKHFGGSAKEIPGIGEIGYIGLTAFVLNVVVTVVLTFVLKAAKAPEGVDETRP
                     EDYTADAGDPGVEAELPPATAGKTH"
     gene            complement(19512..19766)
                     /locus_tag="IE325_RS10535"
                     /old_locus_tag="GCM10018780_21270"
     CDS             complement(19512..19766)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384611.1"
                     /locus_tag="IE325_RS10535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21270"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_190069526.1"
                     /transl_table=11
                     /translation="MSDASEVNRGPVVTPVRVVIALCLVAPFVAMLWVGSYAKTDPAIA
                     GIPFFYWYQMLWVLISTALTMIAYKLWQRDQRGRRGGSK"
     gene            complement(19895..20092)
                     /locus_tag="IE325_RS10540"
                     /old_locus_tag="GCM10018780_21280"
     CDS             complement(19895..20092)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657905.1"
                     /locus_tag="IE325_RS10540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_21280"
                     /product="YbdD/YjiX family protein"
                     /protein_id="WP_190069527.1"
                     /transl_table=11
                     /translation="MRSLRRVLRSVRWYLRELTDESAYDRYVAHVRQGHPDARVPSRRD
                     FERMRTDRQETDPRQGFRCC"
ORIGIN
        1 ccacgacccg ctcgtaggga tcgtcgtcgt cggcggtacg gcgcagcagc gacgaccgct
       61 tctcgatccg cacgatccgc gcgagggtgt ccttcttgcc ggacagatcg ccgacgaggg
      121 ccacccggtc gccgaccacc gccgccttgc ggccgagttc gcgggccttc atcgccagca
      181 cgatccggtc ctcgacgaga caggtcagcc gcccccggtc gacggtgagg accatgccct
      241 cggcggcgtc ctcgtgcttg ggccggatgt tcgtacgggg ccgggtgttg cgtcggccgg
      301 gacgggtgcg gatgtcgtcc tcgtcggtgt gcttgccgta gcggcgcatg gcgtgagtcc
      361 ctacgccccg agcatcccgg tccacagttc ggggaagtcc ggcagggtct tcgccgtcgt
      421 cgccacgttc tcgatgcgta caccctcgac cgcgaggccg atgatcgcgc cggcggtcgc
      481 catgcggtgg tcctcgtagg tgtggaagac gccgccgtgc agccggcgcg ggcggatgtg
      541 cagaccgtcg gcggtctcgg tgacatcacc gccgagttcg ttgatctcct tggtgagcgc
      601 ggccagccgg tccgtctcgt gcagccgcag atgggcgaca ccgcgcaggg tggaggggga
      661 gtccgcgacc gccgcgaccg ccgcgatgcc cggggtgagt tcgccgacct cgctcaggtc
      721 cacgtcgatg ccgtggaccg cgcccgaacc ggtgaacacc agcccgtact cggtgagttc
      781 gcaggagccg cccatctccg tgaagatctc ccgcagccgg tcaccgggct gcgtggtgcg
      841 ggccggccag tccgggatga gcaccttgcc gccggtcacc agcgcggcgg ccaggaacgg
      901 ctgggcgttc gacagatccg gctcgatcgt cagatcacgg ccgagcaggg cgcccggcgt
      961 gacccgccag acgttcggct cgccgcccga ctccggggtg tccacctggg cgccgacggc
     1021 acgcagcatg tcgacggtca tccggatgtg cggcatggag ggcagcgagg agccggtgtg
     1081 ccggacctcc acaccctggt tgaagcgcgg cccggagagc agcagagcac tcacgaactg
     1141 ggacgacgac gaggcgtcga tctccaccgg gccgccctcc agcgcacccc cgccgtgcac
     1201 cgtcagcggc agcgcgcccc ggccgtcgtc gtcgatccgc gcaccgaggg cgcgcaaggc
     1261 gtcgatcaca ccgtgcaggg ggcgctcgta cgaccggggg tcgccgtcga agcggacggg
     1321 accgtcggcc agcgcggcga ccggcggcag gaagcgcatc accgtgccgg cattgccgac
     1381 atcgaccgtg gccgggccgc gcagccccgc ggggagcaca cgccacgcct caccggtgcc
     1441 ctccgggccg acgccctcct cgatgccgac gcccatggtg cgcagggcgc ccgccatcag
     1501 cagggtgtcg cgggagcgga gggggcggcg cagccaaccg ggttccgagg cgagggcggc
     1561 gaggacgagg gcacggttgg tgaccgactt ggaccccggc acgtggaccg tcgcgtcgac
     1621 gggtccgctc gcttgggggg cgggccagag ggcggggtgt gcggcggggt tttgggccat
     1681 gggttcactt tataaggagc gtgtggttcg ggtgcggcgc cgttggggct ggtcgcgcag
     1741 ttccccgcgc ccctgaggtg ggctgtcaca cctccagcag ccagcggccg ccacctatca
     1801 atgagcagag cgacaccgcg tggaacagga acaaccacag ccccgccggc acatgcgtca
     1861 gccgcgacag ctgatccgcg tccgagtccc ccgcccctcc ccgcgcccgc ttcgcctgca
     1921 gctcgaacgc cggccgtacc ccgcccacca gcaggaacca caccaccaca tacgcgaacg
     1981 ccgcctgcac ctgcggcccc gtgaaccagc tgaccagtac gaacgtgccg cccgtgacga
     2041 acacggtcag ggcgccgtac gcgttgcgga tcatgaccag catcgccacc agcaggaccg
     2101 tcgccagcca cagcaggagc gtgatgcggc ccgcagccag cagtgcggcg ccgcccaggc
     2161 ccagcagcgg gggagcggtg tagcccgcgg ccgcggtgag gatcatgccg atgccgtgcg
     2221 gcttgccgcg gctgacggtg aggccgctgg tgtcggagtg cagacgtatg ccggtcaggg
     2281 tccggccggt cagcagcgcg atcaggccgt ggccgccctc gtgggcgatg gtgatggcgt
     2341 tgcgtgagag gcgccacagg acgtgcggga cgacgaaggc gagtgcgacg accagggcgg
     2401 cgatcacgac ccacagatcg gggtcgggct gggtgccgga gacctcgtcc cagagggagg
     2461 cgagcgaggc ggatgcggtg ctgtccatgt aaggcgatgg ctccctgtgg tcggctggaa
     2521 tctggcagtg tggcacgcat gtgcggacgg tatgcagcga gtcgtaggcc cgaggatctc
     2581 gcaggaatct ttgagatcga gacgtgggag ccggaggagt cccttgaggc ggattacaac
     2641 gtggctccga ccaaagaggt cctcgtcgtt ctcgaccgtc ccttgaaaga cgtggacgac
     2701 cccgcgccgg ttcggcaatt gcgcaagctg aagtggggct tggtgcccag ctggtccaag
     2761 actcccgaga gcgccttcaa gatgatcaat gctcgggccg agacggtgca tgagaagccg
     2821 tcgtacaagc gggcgttctc ctcccggcgc tgcatcatcc ccgccgacgg ctactacgag
     2881 tgggtcaccg gcaagcagga gcgggacctg gaggtcgagg ggaagaagaa gcggccgcgc
     2941 aagcagccct acttcgtgct gcccgccgac gggacggtgt tcgcgatggc ggggctgtac
     3001 gagttctggc gggacaagac cctgcccgac gagcacccgc aggcctggtg ggtcacctgc
     3061 tcggtcatca ccacggaggc cgagacgacc ccgctggccg tcgcgcccga ggaaggcccg
     3121 cacacgctcg ccgagatcca cccccggatg ccgctgatgc tgacgccgga ccgctgggac
     3181 gcctggctcg acccctcccg caaggacccc gaggaactgc gcaccctcct cgaccctccg
     3241 cccgccggac tgatgcgcgc ctaccccgtc tccacgctcg tcagcaacgt ccgcaacaac
     3301 ggcccggagc tgctgaagga gctggacggg cccgaagagg gcacactctt ctgatgtgac
     3361 gaccgtgacg accgagatca ttggtacgga ggcgggggac gcccgcatca cctggcaccc
     3421 ggcgaagaag gccaggctgg tcctcgccgc cagtcatggc gccggcggcg gcatcggggc
     3481 ccgggacctt gtggcgctcg ccgaggccct ccccgcccac ggggtgaccg tcgccctcgt
     3541 ggagcagccc tggcgcgtgg ccggcaagaa ggtggcgccc gcgccgaaga ccctggacat
     3601 cggctggcgg ggcctgtggc ccgcgctcgc cgtacccggg ctgcccgtga tcgcgggcgg
     3661 gcgcagcgcg ggggcccgtg tcgcctgccg tacggccgtg gagctcggcg cccatgccgt
     3721 gctcgcgctc agcttccccc tgcacccgcc gggcaagccg gagaagtccc gcgccgagga
     3781 actgctcggg tccggggtgc cgaccctcgt cgtacagggc gggaacgatc ccttcggcaa
     3841 gcccgaggag ttcccggacg gtgacttcga gctggtcgag gtgccctacg gcgaccatgg
     3901 cctcgccgtg cccaagcggg cgcccctcga tcaggacgag gccgtggcgc tcgtcacgga
     3961 cgcggtgatg aagtgggccg ggtcactcgg gtaaagcttg gggaatgtcg gaggcccggc
     4021 cttggttgtg gcggacacag gtgctgaagc accagcgccg acgccgtacg agaggaagtc
     4081 cgccgcatgg gttcgaccca ctgccagagc cgcagcagcc gcgccgacct ggactggacg
     4141 gtgctgcacg cggccaggac cgccactatt cgaggggcgg cgggtacggc aggtcgtcta
     4201 tcctccgatt caggcgggac cggtttcggc cctgcccgga atcttgagga ggtgggtccg
     4261 gttcccggta ccgacgcagg gaccgacaac ggccaggcgg agcagcccga gggcctgggc
     4321 acgagcgcgg agtcgaccgc ggagcgcagc gcgcgcttcg agcgggacgc gctcgaattc
     4381 ctcgaccaga tgtattcggc cgcgctgcgt atgacgcgca acccggccga tgcggaggac
     4441 ctggtgcagg agacgtacgc caaggcgtac gcgtcgttcc accagttccg cgagggcacc
     4501 aacctcaagg cgtggctgta ccggatcctc accaacacct tcatcaactc ctaccgcaag
     4561 aagcagcgtg agccgcagcg ttcggcggcg gaggagatcg aggactggca gctcgcccgc
     4621 gccgagtcgc acatgtcgac gggtctgcgc tccgcggagt cgcaggcgct cgaccatctg
     4681 ccggactcgg acgtgaagga agcgctccag gccatccccg aggagttccg catcgccgtg
     4741 tatctggccg acgtagaggg ctttgcgtac aaggagatcg cggacatcat ggggacaccc
     4801 atcggtacgg tgatgtcccg gctgcaccgg ggccgccgtc aactgcgcgg catgctcgag
     4861 gactacgccc gcgagcgcgg actggtcccg gccggcgccg gagagtcgaa cgaagcgaaa
     4921 ggctcgggct catgagctgc ggagagccgc acgagacgga ctgctccgag gtactcgatc
     4981 atctctacga gttcctcgac agcgagatgc cggacgtcga ccgcgacaag ttcaagcagc
     5041 acttccagga gtgctcgccg tgcctggaga agtacgggct cgaagaggcc gtgaagaagc
     5101 tggtcaagcg gtgctgcgga catgacgacg tgccgaccga cctgcgcgcc aaggttctgg
     5161 ggcggctcga tctgatccgc tcgggacagg ccgtgcccga gcacgacgtc acggcgacac
     5221 cgcaggaatc ctgaacgcac agtcgtcact cgaacgtgct aatcccccgg tcttaggacc
     5281 gcgcacctcc ccctgcccgc cctaggctcc tctgcctgaa gcgcgtggcc tgggaggggc
     5341 gtatggaggc gacacccgca ccggcacgtg gctacgtcct ctgtgtcgcc ctcggcgcgc
     5401 tgtactgcgt gcacacgctg ccggcggacg ccgtcccctg gtgggcggtg gcgctgctgg
     5461 ccgcgctcta cgccgggggc gagcggttgt ccggctcgtt ctatcccgtg ctcctcgccg
     5521 gggccttcct gctgccgccg tccgccgccg cgctggtcgc ggtgccgggc gcgctgctcg
     5581 ccccggccgg cgggcgcccg cgtctgctgc gccgggtgtg gcgggcggcg cagctcgtgg
     5641 tcgtggtgtg ggtggccgcc cgggtgcacg gggaactcgg cgagcacgac gccgtggtgg
     5701 ccgccgactt cccgcacgcg ctgctgccgg tcggcgccgc cgtgctggcg ttctgcctgg
     5761 ccctgagcct gctggacacc gggatcctgg cgctcgccga gcgcgtaccc ccgtggcgcg
     5821 cctggcgtga gcagttcccg cgctccctcg cgccgatcgc cgtgcacggt ctggccggtc
     5881 tgatgatggc cgtgctgtgg cgcagcccct acggtcccgt cgccgcgctg ctcgtgctgc
     5941 tgccgatgtg cgtgtcgtgg tgggccttcg cccagtacca ccgggagcgc gcggcccatc
     6001 aggcgaccat ccgggccctc gtccaggccg tcgacatcaa ggacggctac acccgaggcc
     6061 acagcgagcg cgtcggacag gcctccatga tgatcgcccg tgagctgggc ctcgccggcg
     6121 aacgcgtcga ggtgctccgc ttcgccggga tcctgcacga cgtcggcaag ctgggcgtgc
     6181 ccacgcggct gctgcgcaag aacgggccgc tgacgcccga ggagcggcgg gtgatcgagc
     6241 tgcaccccga gtacgggcac gagatggtcc gcgggatctc cttcctcggc gaggcccggg
     6301 ccgccgtact gcaccatcac gagcggctgg acggcagcgg ctacccctac gggctgagcg
     6361 ggagtcagat cccggagtcg gcacgggtgg tggccgtcgc ggacgccttc gacgccatga
     6421 cgtcgacccg gtcctactcg cgggcccggc ccgtctccga ggcgctgcgg gagctggaga
     6481 aatgcgcggg ctcacacttc gacccccgga tggtcacggc cctcgccggc gccctcgacc
     6541 agcacggctg gcatcccgcg gtgaccgccg acgagcccgc gccgccgacc gccgggcctt
     6601 cggccgaccg tgttcccggg gcgcgtcgat gagggccccg ggtgtggcgg ccaagggggt
     6661 cgtgtcgatg agcgccccga ggccacccgt cctgctcacc ctgatccacg cctgcgccgc
     6721 gctcctcgcc acgggatgtg tgctcggcat cctggccggg ggcctcgccg agcgggccac
     6781 ggccctcgcc ttcggggtcc tcatcaccct cggcgagctc acccggtggg ccggggccga
     6841 gggcagggag gccgcgccgc tcggtgccgc cgccgcactg tcgtacgccc tgctcggcga
     6901 caacggctcg gagcccacac agcacggcgc cgtgcaggtc gtcggagtcg tcctggccgc
     6961 ctcgctgctg ggcagcgtgc cgcacatcgc gcgcgggcgc cccgtgctcg accacctcac
     7021 ccggcgcgtg ctcaccgtcg gcttcgcggc cgtctgcttc caacccctgt ccaaccaggg
     7081 cacgttcgac ggctggggca cctcctacgc gctgctcctg ctggcgatcc tcaccctcac
     7141 cgccctgtgc gacgccctgc tcgccgccgc gctggcgcac acgcgcaccc ggtggccctt
     7201 cgggccgctg ctgcgggacg agctgcgggc gaccctcggg atcgggtcgg cggtctgcgc
     7261 gacgggcgcg gtgatggcgc tggcggtagc cgtgatcggg ctgtgggcgc tgcccgtgtt
     7321 ctcggtgccc ctgctgctga cccagctgtc cgtccgccgc tacagcgccg tgcggaccac
     7381 ctaccggcag accatcgcct ccctcgcccg cgccaccgag atcgccgggt acaccccggc
     7441 cggacacgcc cggcgggtcg ccgcgctcag ccgggacgtg gggcgggacc tgggcctcac
     7501 cgaggccgag ctcaccgtgc tggagtacgc ggccctcatg cacgacatcg gtcagctcag
     7561 cctcgtcgac ccggtgccgg acggggccac cgccgtgctg cccgtagaga aacagcggcg
     7621 gatcgcgctg ctcggagggg ccgtcgtacg gcagaccggc gtgaacccgc aggtcgcgct
     7681 ggtcgtggag cggctcgccg acccctgccc cgagcagccg ctgcccgcgc ggatcgtgcg
     7741 ggcggtgaac gcctacgagg agatggcgcg cgatgccggg ccgggagggc cgctgaaggc
     7801 gctcgaagag ctgcgactgg gtaccgcggg ggagtactcg gcggaggtgg tggaatcgct
     7861 ggcccaggtg ctgtccaggg agggtctggc aacgcccttg gctgggtaac ccatgggtaa
     7921 tgagcgccct tccagccgta cgtggttgga tgcgaatgag agtgtgtccg ggggcgagca
     7981 ctagccagcc cactccacgg aactggcagg cgggaatcgt gaggatcttc ggcaagggac
     8041 ggcaccggcc ctccgcctcc tggcggcagg ccaccgaccg ggcgttcacg ctcatcggcg
     8101 acggccggta cgaggacgcg ggcgcgctgc tgacacgtgc cgccgatctg gagccctggc
     8161 tttcggagtc ctggttcaat ctcgcgctgc tgcacaagtt ccggcacgac tgggagcagg
     8221 cccgggccgc cggactgcgt gccgtggcgc tgctcgaccg ggagaccggg gcgcccgact
     8281 ggtggaacgt cggcatcgcc gcgaccgcgc tgcaggactg gccgctggcc cggcgggcct
     8341 ggcaggcgta cgggctgcgg gtacccggcg gggccaccga ctccggcgag ccggtcggca
     8401 tggacctggg cagcgctgcc gtacggctgt ccccggaggg ggaggccgag gtcgtgtggg
     8461 ggcgtcgtct cgaccccgcg cggatcgagg tgctgtcgat tccgctgccg tcgtccgggc
     8521 ggcgctgggg cgaggtcgtg ctgcacgacg gcgtcccgca cggcgagcgg accacgacgt
     8581 ccgggcacgc ctaccccgtc ttcgacgaga tcgagctgtg ggcgccttcg ccggtgccga
     8641 cctgggtggt gctgctggag gcggcgaccg aggccgaccg ggacgcgctg gagcagctcg
     8701 ccgcggacgc ggggttcgcc gcggaggact ggtcctcgtc ggtgcggctg ctgtgccgga
     8761 tgtgttccga gtcgcggatg ccgtccgatg agggggacgg ggagcatctg gatccgcacg
     8821 atcacagtga gccggggcat ccggggccgc tcggccatcg gaccgatggg cagctgtggg
     8881 tgccggagcg ggagtgcggg gtggctgcgc cggctgcgtt ggtccggggg ctgctggacg
     8941 gatgggttgc cgacagtcct gattccaggg attggcggga cttggaagag gtctgctagg
     9001 cgccgtaggg gcggggtcgt cggcaggctg cgggctgtgt gtggttgatc gcgcagttcc
     9061 ccgcgcccct atcggggcgc tccccgtacc ctgtatcagg attcaccctc tttctttgtg
     9121 caggaaggca tacgtcggtc atggcccagc aggacaccga gcagcagcac gcgggcgtgc
     9181 tccccgtgga cgacgagggg ttcgtcgtcg acaccgagga cgcggaggag cgcgagaacg
     9241 cctggcgtga gcgcggcacc tcgcggccga tcaccgtggt ggggaacccg gttctgcaca
     9301 aggagtgcaa ggacgtcacc gagttcggcg ccgagctgga gcagctggtg gcggacatgt
     9361 tcgcctcgca gcgcaccgcc gagggcgtgg gcctggccgc caaccagatc ggcgtcgacc
     9421 tgaaggtctt cgtctacgac tgccaggacg accagggcga gcggcatgtc ggcgtcgtct
     9481 gcaacccgaa gctcgtcgag ctgcccgccg agcagcgccg gctggacgac agcaatgagg
     9541 gctgtctgtc ggtgccgacc gcgtacgcgg cgctcgcccg ccccgactac gccgaggtga
     9601 ccgggcagga cgagaagggc aacccgatca aggtccgcgg caccggctac ttcgcccggt
     9661 gtctgcagca cgagacggac catctgtacg gctacctcta catcgaccgt ctctccaagc
     9721 gcgagcgcaa ggacgcgctg cggcagatgg ccgagaacga gccccgctac gccgtggttc
     9781 ccaacgactg aggtccactg accgaggtcc tcatacgctc ctggcgctcg gcgcctggtc
     9841 aggttcccca cccggccagg cgccgttcgc atgttcgtcg catgttcgat cgcgtacgcg
     9901 cgaaatgaag caaatacgtt cccagaacgg tcagttgtgg tgctgaatgg aggtgcgggg
     9961 atacgcgact gcacaactgg cggctgagag gagtttgttc gtgcatgctt tctcggacag
    10021 caccacagcg acatcgacgg cggtccaggt tccaccgtcg ctctctctcc cggtgatcga
    10081 agcggcgttt cccaggcgac ttcatcccta ttggccccgg ctccaggaca agacccgggc
    10141 ctggttgctc cagaagcgac tgatgccggc cgacaaggtc gaggaatatg ccgacggcct
    10201 gtgctacacc gacctcatgg ccgggtacta cataggcgcc ccggacgatg tcctccaggc
    10261 gatcgcggac tacagcgcgt ggttcttcgt ctgggacgac cggcacgacc gggacatcgt
    10321 ccaccgccgc ccggcggcct ggcggcggct gagattccgg ctgcacacgg cgctcgactc
    10381 ccccgaggac catctgcacc acgaggatcc gctggtggcg gcgttcgcgg acagcgtggg
    10441 acggctgttc tcgttcctgc ccggcacctg gaacgcgcgg ttcgcccggc acttccacgc
    10501 cgtgatcgag gcgtacgacc aggaattcca caaccgaatg gaagggaagg tccccaccgt
    10561 cgaggaatac ctcgaactgc gccggctcac cttcgcacac tcgatctgga ccgatctgct
    10621 ggagccgagc gtcggaatgg aacttccgga atccgtgcgc aaatatccgg catatcgacg
    10681 ggcggcactg ctgagccagg aattcgccgc ctggtacaac gatctctgct cattcccgaa
    10741 ggaaatagcg ggcgacgagg tccacaatct cggtatcagt ctcatcaccc acaaggggct
    10801 gactctcgaa gagacgatcg cggaagtcag acgacgcgtc gaggactgca tctccgattt
    10861 cctggtggcc gagcgcgagg ccctggaatt cgccggcctg ctggccgacg gcacaccgcg
    10921 gggcgcggaa ctcggcaccg ccgtgcgcgc ctgcgtcggc aatatgcgca actggttcag
    10981 ctcggtctac tggttccacc acgagtccgg ccgttaccgc gtcgacagct gggacgaccg
    11041 gtccacaccc ccgtacgtca acaacgaagc ggcaggtgag ctatgaccac ggtcctggaa
    11101 ctgcgtgaac cgcccctcgc cggcggggga gtcccgctgc tgggccacgg ctggaggatg
    11161 gtccgcgatc cgctggcctt cgtggcggcg ctgcgcgacc acggcgacgt cgtacggatc
    11221 aaactggggc cgaagacggt gtacgccgtc accacacccg acctcaccgg cgcgctcgcg
    11281 ctgagcaccg acttcgagat cgccgggccg ctgtgggagt ccctggagag cctgctcggc
    11341 aaggagggcg tggccaccgc caatgggccc cggcaccggc ggcagcggcg caccatccag
    11401 cccgccttcc ggctcgacgc catccccggg tacgggccga tcatggccga ggaggcgcat
    11461 gcgctgaccg agcgctggcg gcccggcgag accgtcgact gcaccgccga gtccttccgg
    11521 atcgccgtgc ggatcgtggc ccgctgtctg ctgcgcggcg cgtacatgga cgagcgggcc
    11581 gaccggctgt gcgccgccct cgacaccctg ttccgcggca tgtaccggcg gatggtgatc
    11641 cccctcgggc cgctctacga cctgccgctc ccggccaacc gccgattcaa tggcgccctg
    11701 gccgattttc atctcctggt cgacgaggtc atcgccgaac gcagggcatc cggtcaaaag
    11761 ccggacgatt tgctgacggc attgctgcac gcgaaggacg agaatggtga ccccatcggg
    11821 gagcaggaga tccatgacca ggtcgtcgcg atattcaccg ccggcaccga aacggtggcg
    11881 tccacgatct tgtggctgct ccatgtgctc gcggaacatc cggaacacgc cgacaaggta
    11941 agcgcagagg tcgaatccgt caccggcggt cgccccgtgg cattcgagga cgtccgtgcg
    12001 ctgcggcaca ccaacaatgt cgtcgtggaa gcgatccgtt tgcgccccgc gatctggatt
    12061 ctgacgcgcc gggcggtggc cgacacatca ctcggtggct atcgcattcc ggccggagcc
    12121 gacatcgtct acagccccta cgccgtccag cgcgatccga agtcgtacgt gcgccacctc
    12181 gacttcgacc ccgaccgctg gcttcccgag cgcgtcaagg aggtgccgaa atacgccatg
    12241 agccccttcg gggtcggcaa ccgcaagtgc ccgagcgacc acttctccat ggcgatgctg
    12301 tcgctgatca cggcggccct ggccggccgg taccgcttcg agcaggcgtc cggctcgaac
    12361 gactcgaccc gggtggggat caccctgcat ccgcacaccc tgctgctgac gccggtcgag
    12421 cgggagtagc tcaggccgcc tcggggccct ggaacgtccg ccggtaggcg ttcggtgtcg
    12481 tccccagcgt ccgtacgaac tgatggcgca gcgcggccgc ggtgccgaac ccggtccggc
    12541 ccgcgatcgc gtccacggtc tcgtccgtcg cctccagcaa ccgctgggcc agcagcacac
    12601 gttggcgcag gatccagcgg tagggagtcg tgccggtctc ctgctggaag cggcgggcga
    12661 aggtgcgcgg tgacatgagc gcgcgctcgg cgagctgctc gacggtgacg tcctcgtcga
    12721 ggtggcgctc catccaggcc agcacctcgc cgacagtgtc gcactgggag cgcggcagcg
    12781 ggcgctcgat gtactgggcc tgtccgccgt cccggtgcgg cggcaccacc atgcgccggg
    12841 cgatcttgtt ggcgacctcg ggcccctgct cctggcgcac gatgtgcaga caggcgtcga
    12901 tcccggcggc ggtgccggcg ctggtgatca ccgggccctc gtcgacgtac agcacatcgg
    12961 gctcgacgat cgcccgcggg tgctgtcggg tcagttcccc ggcgtgcttc cagtgcgcac
    13021 tgcaccgccg cccgtcgagc agcccggccg cgcccagcac gaagacgccg gagcacacgc
    13081 tgagcacccg cgcgccccgc tcgaccgctc tgaccaggga gtccaacagc tcgggcggat
    13141 agtcgcgcac gacatagtcg ctgcccgcgg gcaccgcgat caggtcggcc tcctcaagcc
    13201 gctccagacc gtagggcgtg gagacggaga gtccgccgac atgggtgccc agcgtcggcc
    13261 cctccgccga tacgacggcg aagtcgtacg tgggcagccc ctcgtcactg cggtcgatgc
    13321 cgaacacctc gcagacgacg ccgagttcga agggatgcac gccgttgagc aggacggccg
    13381 ccacgttctt cagcatgctg ccagtgtgcc tcggaagtgg cagtaaatcg agggtgtacg
    13441 gcagtcctgc cactgtcagg agtgtcttgc cggtatgaga cttacctcat gaacgcaatc
    13501 ctcgaatacg tcgccgtagt gattctcttc ctgatcctcg cgggtccggc gctcgtggga
    13561 catctccacg agcgccggat cgaccgccag ctgaaggcgg tggaatccaa gaagactcag
    13621 aagtcctcgt ccaggtcgac ggtgccctcc accgccacct ggtacgccga gggacgccgc
    13681 tcgaagaagt tggtgagctc ctgaacaccc tgcagctcca tgaagctgaa ggggttctcg
    13741 gagccgtaca ccggagcgaa gccgaggcgc gtcaggcgct gatcggcgac acactccagg
    13801 tactgccgca tcgagtcggt gttcatgccc gggaggccgt caccgcacag gtcgcgcgcg
    13861 aactgcagct cggcctcgac ggcctccctc agcatgtcgg tgacttcctg ctggagctgg
    13921 tcgtcgaaga gctccggctc ctccttgcgg acggtgtcga ccacatcgaa ggcgaacgac
    13981 atgtgcatcg tctcgtcgcg gaacacccag ttggtgccgg tggccagacc gtgcagcagg
    14041 ccccggctgc ggaaccagta gacgtaggcg aaggcaccgt agaagaacag gccctcgatg
    14101 cacgcggcga agcagatcag gttcagcagg aagcgacgcc ggtcggcctg ggtctgcagg
    14161 ctctccagct tctcgacctc gttgatccac ttgaagcaga actcggcctt ctcgcggatc
    14221 gaggggatgt tctcgacggc gtcgaaggcg gccgccctgt cctccgggtc ggggaggtag
    14281 gtgtcaagga gcgtcagata gaactggacg tgcacggcct cctcgaagag ctggcgcgac
    14341 aggtacaggc gcgcctccgg ggagttgatg tgcttgtaca gcgtcagcac caggttgttc
    14401 gccacgatcg agtcgcccgt cgcgaagaac gcgaccagcc ggccgatcat gtgctgctca
    14461 ccctcggaca gcttggcgag atcggcgacg tccgagtgga ggtcgacctc ctccacggtc
    14521 caggtgttct tgatggcgtc ccggtagcgc tcgtagaagt ccgggtagcg catggggcgc
    14581 agggtcagct cgaagcccgg gtcgaggaga ttggcgttac gggtactcat tactggcagg
    14641 cctcgcagga ctcggggttt tccagggagc aggcgacggc gtcttcgggc gccggctgct
    14701 gggcggggat ggcggcttgg gcctgggcgg cgcgggcgat gcgggtcgcc gggcgcgagc
    14761 gcaggtagta cgtcgtcttc aggcccgact tccaggcgta cgcgtacatc gaggagagct
    14821 tgccgatggt cggcgtctcc aggaacaggt tcagggactg cgactggtcc aggaacgggg
    14881 tccgggcggc ggccatgtcg atgagcccgc gctgcgggat ctcccacgcc gtgcggtaca
    14941 gcgcccgtac gtccgccggg atccaggcga agtcctgcac cgagccgttc gattcgcgca
    15001 gcgcctcacg ggtgcgggcg tcccacacgc cgagcgcctt cagctcgtcg accaggtagg
    15061 agttgacctg gaggaactca ccggagagcg tctcgcgctt gaacaggttg gagacctgcg
    15121 gctcgatgca ctcgtagaca ccggcgatgg acgcgatggt ggcggtgggc gcgatggcga
    15181 gcagcaggga gttgcgcaga ccggtggtgg cgatacggcc gcgcagggcc gcccagcgct
    15241 ccggccaggt cagctcggcg tccgggtagt ggtcggggtg caggacgccc tgggcggtac
    15301 gggtcttctc ccaggcaggc agcgggccgc tgcgctcggc gaggtcggcg gacgcctcgt
    15361 acgcggcgag catgatgcgc tcggcgatcc gcgtggagag cgccttcgcc tcgggcgagt
    15421 cgaagggcag ccgcagcttg aagaacacgt cctgcagacc catcgcgccg aggcccaccg
    15481 gccgccactt ggcgttggag cggcccgcct gctcggtcgg gtagaagttg atgtcgacga
    15541 cacggtccag gaaggtgacg gcggtgcgga cggtggcgtc gaggcgctcc cagtcgatgt
    15601 ccccgttgtc cacgaacgcg ccgaggttga ccgagcccag gttgcagacc gccgtctccc
    15661 cgtcgtcggt gacctccagg atctccgtgc agaggttgga cgagtggacg acatggcccg
    15721 gcagcgccgt ctggttggcg gtgcggttgg cggcgtcctt gaacgtcatc cagccgttgc
    15781 cggtctgcgc gagggtgcgc atcatacggc cgtacagatc acgcgccggg atggtcttct
    15841 tggcgagccc ggcggcctcg gccttgcggt aggccgcgtc gaactcctcg ccgtgcagat
    15901 cgaccagctc gggcacgtcg gcgggggaga acagcgacca tacggcgtcc gcgttcaccc
    15961 ggcgcatgaa ctcgtccggg atccagtgcg cgaggttcag attgtgcgta cggcgggcgt
    16021 cctcaccggt gttgtcgcgc agctccagga actcctcgat gtcggagtgc caggtctcca
    16081 ggtacaccgc ggcggccccc ttgcgccggc cgccctggtt caccgcggcg acggaggcgt
    16141 cgagggtctt caggaacggg acgatgccgt tggagtgccc gttggtgccg cggatcagcg
    16201 aaccgcggct gcggatgcgg gagtacgcga tgccgatacc gccggcgtgc ttcgagagcc
    16261 gggcgacctg gtggtagcgg tcgtagatgg agtccagctc gtcgagcggg gagtccagga
    16321 ggtagcagga cgacatctgg gggtgccggg tgccggagtt gaacagggtg ggggaggagg
    16381 ggaggtagtc gaggcggctc atgagcccgt agagcgcggc gacttcgtcc agtgcgcgga
    16441 cactgtcgtc ctcggcgaga ccggcggcga cccggagcat gaagtactgc ggagtctcga
    16501 tcacgcgacg ggtgatcggg tgccggagca ggtaccggct gtgcagggtg cgcaggccga
    16561 agtagccgaa gcggtcgtcg gcgccggtgt cgaccagggc gtcgagacgg gccgcgtgga
    16621 tccgcgcgaa ctccgcggtg cggtcggcga tgaggccctc gcggtggccg acggcgaccg
    16681 acccggtgaa ggacgtgacg ccctgcgagg cggcctcggc ggcgatggag agggtcagca
    16741 gcctggccgc cagcctgctg taggcggggt cctcggagat gagaccggcg gccgcctcgg
    16801 tggccagctc gcgcagctcc gcctcgtccg cgcgcgcgga ccggccccgc agcgcggcgg
    16861 cggcgacccg gccggggtcg gcgtcgagga ggtcggcggt cagctcggtg agggtccgca
    16921 gcagtgcggt accgggaccg tcggtcttca gctcggtgac tgaaaccggg tcggctggcg
    16981 cgatggtcac gtgggggctc tccctcgctc ggcacggggc ctcgccgagg gcagggggcg
    17041 gtacacgagc gcacggggcg tcgcgtccac cggcccattc cacgaggccc ggacgtcagg
    17101 gcgcaccggc cgggtggccg ggcgcgctgt cggcaggtcc tcggactgac tctcatatgt
    17161 gtgcgaacac gcatgagtac accgttgcgg gacagttccg gattcgcacc ggattcccct
    17221 gcgacgacag cgagcacgag catacatctt gtgccgggct gtcgtatcac ccccagatgt
    17281 tgtgtcgcgc tggtttcaga gcgtcaactc gtaggtgaga agagtgatgt cgtcgaggtg
    17341 cgggatcgga ttccagtccc gctccggtgt gcggacgaag cccagccgtt catagatgcg
    17401 gtgggctccg tgcatggtgc gctgggtcga caggacgatc ctcgcgcagc cctcggtggc
    17461 ccgcgcccga tcgacgcagg cgcggacgag ggcctcgccg gcgccacggc cccgtccgtc
    17521 gtgcgcgacc gccagcatgc ggatctccgc ctccgagggg cgggctatgt cggccatggg
    17581 gccgccggac gggacgaagg tcacgccgcc cagcagccgg ccgttctcga cggccaccag
    17641 cacctcggcg gcggccgcgc gccccgccac gtccttcagt tcgctcaggt attcgtcgct
    17701 ctcgccgaag tcgaggaggc cgtcctggag ataggcccgg gcggtgatct caccgagggg
    17761 ctcgtactcg ccgggttccg cccgccggat cacgatgtcc atggggccga gtctgccgga
    17821 cgcgacgagc ggcgggccgc cggatttctc cgnnnnnnnn nnnnnnnnng tatcgctcgg
    17881 tatcgctcag tgggtcttgc ccgcggtcgc cggaggcagt tccgcctcga cgcccgggtc
    17941 gcccgcgtcc gccgtgtagt cctccggcct ggtctcgtcc acgccctccg gggccttcgc
    18001 ggccttcagg acgaaggtga ggaccaccgt gaccaccacg ttcagcacga acgccgtgag
    18061 gccgatgtag ccgatctcgc cgatgcccgg gatctccttc gccgacccgc cgaagtgctt
    18121 ctgggtcggg gaggcgacgc cgtacgcggc gaccgtgccg tagatcatgc cgaccgccca
    18181 gccggccagc agggcccagc ggtggaacca gcgggtgaac aggccgccga ccagggccgg
    18241 gaaggtctgc aggatccaga tgccgcccag cagctggaag ttgatggcga ccgtcttgtc
    18301 catggtcagg acgaagacca gtgcgccgac cttcaccagc agggacacga tcttggagac
    18361 cttggtctcc tgcgcgggcg tcgcgtccgg cttgatgaag tccttgtaga tgttgcgggt
    18421 gaagagattc gcggccgcga tggacatgat ggccgccggc acgagggcgc cgatgccgat
    18481 cgctgcgaag gccacgcccg cgaaccagtc cgggaacatg ttctcgaaca gctgcgggat
    18541 cgccagctgg ccgttctgca ccttgatgcc ggccgcgatc gccatgaagc ccagcagcgc
    18601 cagcaggccc agcatcaggg agtacagcgg caggatcgtg gtgttgcggc ggatcacctc
    18661 acggctgcgc gaggacagcg tcgcggtgat cgagtgcggg tacatgaaca gcgcgagcgc
    18721 ggagcccagc gccagcgtgg cgtacgtcca ctgcccggcc tcggccggca ccagcgcacc
    18781 gcgcggcgcg cccgtcgccg ggttggtctg gctgtacgcc tcgcccgcct tggcgaagat
    18841 ctcgtcgaag ccgcccagct tgatcgggat gtagatgatc gccaccgcga tgacgatgta
    18901 gatcagcgtg tccttcacga acgcgatcag cgcgggggcg cgcagaccgg acgagtaggt
    18961 gtacgcggcc agcacaccga aggcgatgag cagcggcagg tccttgatga accagttggt
    19021 gttctcgccg ccgccgacgc ccatcacgtc gagcacggcc tggatgccga cgagctggag
    19081 cgcgatgtac ggcatcgtcg ccaggatgcc ggtgaccgcg acggccagcg acaggccctt
    19141 ggagccgaag cggccgcgca cgaagtccga ggtcgtcaca tagccgtgct tgtgggacac
    19201 cgaccacagg cggggcagga acgtgaagat caacgggtag acgaggatcg tgtacggcac
    19261 cgcgaagaag cccgccgccc cggccgcgta gatcgccgcc gggaccgcca cgaacgtata
    19321 cgccgtgtac aggtcgccgc cgagcaggaa ccaggtgacc caggtgccga acgaccgtcc
    19381 gcccaggccc cattcgtcga ggctgtgctc gttctcggcc ttgcgccagc gcgcggccag
    19441 gaagcccatg accgtgacgg ccaggaagaa gaagatgaag acgccgagcg cgacgccgtt
    19501 cacgccgtcg ttcacttgct acctccacgg cgtccgcgct ggtcacgctg ccacaacttg
    19561 tacgcgatca tcgtcagcgc ggtggagatc agcacccaga gcatctggta ccagtagaag
    19621 aacgggatac cggcgatcgc cgggtcggtc ttggcgtacg agccgaccca cagcatcgcc
    19681 acgaagggcg cgacgagaca gagcgcgatg acgacccgta cgggcgtcac caccggccct
    19741 ctgttcactt ccgaggcatc tgacatctga cggctccgtc ccctcactga tcacctgaga
    19801 aacgcccggg caatgtaggt gacggtgcaa cgacagcgga agaccctgtc cgcatatcgg
    19861 atgtggagga ttggtgtagg cggcaacggc atgctcagca gcagcggaac ccctggcgcg
    19921 ggtcggtctc ctgacggtcc gtccgcatcc gttcgaagtc acgccgggag ggcacccggg
    19981 cgtccggatg cccttgccgt acatgcgcga catagcggtc gtacgccgat tcgtcggtca
    20041 gctcccgcag ataccagcgg acgctacgga gtacgcgccg aagcgagcgc atcgcgctcc
    20101 tcctccttct cctccttggt cgggatcagc cccgccggag cgatgatctt cgactcgaca
    20161 tacggcgcct cgctcagcgt ggacagcgcc gggcggcgga tgtgccggac gcagacgcgg
    20221 gtggcgtcgg cgatcacgac gacgatcagg atcgcgaggg ccgcggtgag gacgccgtcc
    20281 accgtggagt tggtgaccac ggtgtgcatg tcgtccatgg acttggcggg cggcaggacc
    20341 tcgccgcggt cgatggcgtc ctggaagacc tggcgctgct tgaagaagcc gaccttgggg
    20401 tcgctggaga acaccttctg ccagctggcg gtcagggtga ccgtcgcgtc ccagaccagc
    20461 ggaaccccgg tgatccaggc ccacttgagg cgcccggact tcaccagcag ggtcgtgcag
    20521 acggcgaggg cgacggccgc gagcaactgg ttggagatgc cgaagatcgg gaagagctgg
    20581 ttgatgccgc cgaggggttc gtggacgccg acccacagga agtagcccca gaggccgcac
    20641 acgatggcgc tggtgatggc cagacccggc ttccaactga cgttcttgaa gggccggtag
    20701 acgttgccca gcatgtcctg gagcatgaac cggcccaccc gggtgccggc gtccagcgcg
    20761 gtcaggatga acagcgcctc gaacatgatg gcgaagtggt accagaaggc acgcaggccg
    20821 cccccggtga cctgcgagaa gatctccgag acgccgatgg cgagggtcgg cgcaccgccg
    20881 gtccgggaga gcagcgacgc ctcctcgacg ttctccgccg cccgcgcgag cgcctccggg
    20941 gagatctggt aaccccaact gcccaccacc tgcgaggcgt tctgcaccgt gtcgccgatg
    21001 accccggcgg gcgcgttcat cgcgaagtac aggcccgggt cgatgatgct cgccgcgacc
    21061 agcgccatca cggcgaccga cgactc
//
