LOCUS       NZ_BNBM01000001        30723 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000001
VERSION     NZ_BNBM01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1203604)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1172881
            Orig. end                         :: 1203604
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..30723
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /product="betalactone"
                     /region_number="7"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..30723
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="neighbouring"
                     /product="terpene-precursor"
                     /product="betalactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21038
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21038
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11038](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11038)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(302..316)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     misc_feature    303..317
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.83"
                     /tool="antismash"
     gene            complement(826..2724)
                     /locus_tag="IE325_RS05140"
                     /old_locus_tag="GCM10018780_10400"
     CDS             complement(826..2724)
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552431.1"
                     /locus_tag="IE325_RS05140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10400"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_190068434.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 1.6e-83,
                     bitscore: 276.0, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.3e-08, bitscore:
                     28.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPPQLPCHDTHPAPPAPTARTGRPRSPDLTTLGGPHDVRALPAG
                     QLAALARDIRTFLIEKVCASGGHLGPNLGMVELTIALHRVFDSPRDAILFDTGHQAYVH
                     KILTGRAADFDRLRQAGGLSGYPSRAESAHDWSENSHASASLSYADGLAKAHELRGHRD
                     RSVVAVIGDGAMTGGMAWEALNNIGAGELPVVVVLNDNGRSYAPTTGALTNQLDALKHS
                     GAVSDGAGANLFTRIGFTYLGPVDGHDTAALEAVLEQARRLRRPVLVHAVTVKGWGFAP
                     AEDDEADCLHAVGTVDAATGMPAPAPASGPPAVSWTSLFGQALLELAGEREDLVAITAS
                     MLRPTGLYSMAVKYPERVFDVGIAEQHAVTSAAGLAMGGFHPVVALYSTFLTRAADQVL
                     MDVALHRLPVTFVLDRAGITGPDGASHHGMWDASLLGIVPGLRLAVPRDGGQLRSLLRE
                     ATAHEGPTALRFPKGRAGQDLAAVRSAGSVDVLSESGVRDVLLVSYGPLAPMCLKAAAR
                     LTEQGIGVTVADPRWATPVAPELLDMAARHRLVVTVEDNSRTGGVGSTLAQTLRDHAIT
                     VPVHNLGLPRAFLTHGPRDQLLADAGLTPSQIAHAVLRARAGKPLKQTASTGGSPQ"
     gene            complement(2865..4955)
                     /gene="pabB"
                     /locus_tag="IE325_RS05145"
                     /old_locus_tag="GCM10018780_10410"
     CDS             complement(2865..4955)
                     /EC_number="2.6.1.85"
                     /GO_function="GO:0046820 - 4-amino-4-deoxychorismate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008153 - para-aminobenzoic acid
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pabB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982616.1"
                     /locus_tag="IE325_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10410"
                     /product="aminodeoxychorismate synthase component I"
                     /protein_id="WP_190068435.1"
                     /transl_table=11
                     /translation="MRVLLIDNYDSYTYNLYQLLAKVYGSTPVVVRNDAAAWSHLDLDG
                     FDAAVISPGPGHPAVPRDFGRSRDILADTRLPVLGVCLGHQGMGLLADARITPAPQPRH
                     GHLSTIRHSGDGLFAGIPQEFTAVRYHSLSIAEPVPAHLEITARAEDGVVMGLAHRDRP
                     WWGVQFHPESICTEHGALLVANFRDLALAPGTRQGGGIGTNGVRVSDAPTTPLPRPVRL
                     QAQIGTLDRAVDTEAAFQALYGADARSFWLDSSHVEPGLARFSFFGSAAAPGAEMLTYR
                     VEDKHVVVDPAGGVPRLETGTIFDALDRRTGRMVEGAEELPFDFLGGYVGYFGYELKAD
                     LGAQHPHRSKTPDAVWLQADRFIAVDHAENRTYIVAVCEQQDLVAAEKWISTVIPVLAE
                     LPTAQSDTSPPPRAENHEASRRLARSRTQYLADIRECDRRLREGVSYEICLTNKLHLPA
                     PANDFAYYQRLRRLNPAPYAAFLRLGEVTVLSSSPERFLKVDAARTVETKPIKGTAPRH
                     PDPRTDDERRRSLQMDPKTRAENLMIVDLLRNDLGRICEVGSVTVPSLMATESYATVHQ
                     LVSTVTGTLRDGKSAVDAVRACFPGGSMTGAPKLRTMEIIDTLEGEARGVYSGALGFIG
                     YTGTTDLSIVIRTAVSHDGELTIGAGGAIVLDSDPDAEYEEMLLKAESTLRALPKARVS
                     GS"
     gene            complement(5036..6055)
                     /locus_tag="IE325_RS05150"
                     /old_locus_tag="GCM10018780_10420"
     CDS             complement(5036..6055)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AurF"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602546.1"
                     /locus_tag="IE325_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10420"
                     /product="diiron oxygenase"
                     /protein_id="WP_229911652.1"
                     /sec_met_domain="AurF (E-value: 8.7e-61, bitscore: 201.6,
                     seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEMLDEGEFGALPVAERLRSLPEHDPNDPVENAVISRLADNWYR
                     RATVKRREETLDDVFERDRPDFPVALLPFRNHPTYLGLDDEIKARLLAWGWVAFNKNVM
                     DIEQFVVNPGFSLIAKDAFGTGLGDSMTIAVTQAMVDEQYHTLMHLNASAVTRRQRGWR
                     MPETALPRGYKTRRHTHRLAAAETPEQQALVSLAFTTVAEISINAHLDLIAEDHEIQPV
                     NRMTAVLHNRDEYCHASIANTVVQEAWKRFTAEQRGCFLTELADGMEAFAAHDFTTWAR
                     IMELLEVEGGAEMLRDIKNTSGSGRLLQDFSGLRQLCQELDVFDSVPFDWSTVKTETP"
     gene            complement(6036..6851)
                     /locus_tag="IE325_RS05155"
                     /old_locus_tag="GCM10018780_10430"
     CDS             complement(6036..6851)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009339754.1"
                     /locus_tag="IE325_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10430"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_190068436.1"
                     /transl_table=11
                     /translation="MTDSIWQGADVDLDAYLSRVGYEAEVAPDLGTLRGLHAAHVEAIA
                     FENIDAVLGRAVPLDLDSVQEKIVRRGRGGLCLEQVVLMAAVLDRIGFTFSAFAARSRI
                     RTGNKLGPAVHIALCVTLDDERWLFDVSFGGYGLHEPIRLAEGARLDGDWPFDVVREPH
                     GEYVLRFLRAEGPAELYGFTTDARYPADFEVLNHYCLTHPRSPFNHRVILQRTQPKVRH
                     VLIGNTLTEIRPGEPATFRELDDDEALSAPGKIFGITLDHKDHYGRDAR"
     gene            complement(6887..7825)
                     /locus_tag="IE325_RS05160"
                     /old_locus_tag="GCM10018780_10440"
     CDS             complement(6887..7825)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358735.1"
                     /locus_tag="IE325_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10440"
                     /product="4-hydroxybenzoate octaprenyltransferase"
                     /protein_id="WP_229911653.1"
                     /sec_met_domain="ubiA (E-value: 4e-37, bitscore: 124.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTPAAVSRDNSPMLQRISAHMVKKSPDSIRSYLILMRLHAPTG
                     VVLYLLPGLWSLTLATEQRPDLLAVVWLALAAVLVRGASCAVNDVVDKDIDAQVARTAS
                     RPVAAGTISVGKALLFGAAQAVASLAILALINTETALVVGASYPFLVAYPYMKRISPWP
                     TAWLALVISVYPMAGWTAVTGSVDYPPTVYGLYACAFFWTLFHDTVYSHQDKEYDRSIG
                     VKSSALMFGESSKAWLTVFIVLSVAGALWAGIEAETGWAFYPLVVGAGALLSYQVVRVN
                     LDDPQSCWDTFVTNRYFGWIILAATIAGQFT"
     gene            complement(7822..8991)
                     /locus_tag="IE325_RS05165"
                     /old_locus_tag="GCM10018780_10450"
     CDS             complement(7822..8991)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009339637.1"
                     /locus_tag="IE325_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10450"
                     /product="cytochrome P450"
                     /protein_id="WP_190068437.1"
                     /sec_met_domain="p450 (E-value: 4.2e-20, bitscore: 67.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPAQLPFEQTHLLHVAPLLRTLQSEGTVHRVRTPEGDEAWLVT
                     GHAEVQRLLDDDRLSRSNPDPGAARDSGAALLDSLLGGFATDHARLRALLEPHFAPERM
                     RALRSHVETLTERLLDELAGQAPPVDLRQALALPLPILVMCEWLGVPHEDKDRFGSWTQ
                     DAANVGDRIRSKQGMAELFGYCQKLIAHKRQNPGDDAISRLCATEGISDTEVVGLTALL
                     LFGGYETTVARIGTGALLLLTNPEQRQALLDDPGLVPGAVEEILRRSMPNPHNGGMPRY
                     ALTDLEIDGTTIRTGELVLLNIIAANHDQTVFTDPERVDVTRETAGSLTFGHGTHYCVG
                     APLARMQLQVALARLVARFPTMRLAVDVAELKLRHDTLLGGLVELPVTW"
     misc_feature    complement(8581..8583)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8984..8995)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(9076..9954)
                     /locus_tag="IE325_RS05170"
                     /old_locus_tag="GCM10018780_10460"
     CDS             complement(9076..9954)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (88-255). E-value: 2.2e-13. Score:
                     41.0. Matches aSDomain: nrpspksdomains_IE325_RS05170_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640631.1"
                     /locus_tag="IE325_RS05170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10460"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_190068438.1"
                     /transl_table=11
                     /translation="MTTTQDTSVRPVIRSEFERRAQAHYETKTQDPINLLLGEEDGLYH
                     HHYAVGPYDKSVLEVPRPERDAAILAEMTRMENEQVELVLHGLAPLSPDARVMDGGSGR
                     GGTAFLVNRRFGCEVVGVNFCAHHIEFAERLAKEKHGCDDKVSFKYANMCDTGLPADSF
                     DAVYTNETTMYVDPAEAFAEFARVLRPGGRYVCVTWCANDAVSTTSEAVKAIDDHYDCH
                     INNRSDYFKALADNHLVPSQVWDLTQEAIPHWELRSHWGLATGVEQPFLDAHRSNELNY
                     IVVVAEYTPPA"
     aSDomain        complement(9190..9690)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS05170_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.20E-13"
                     /label="IE325_RS05170_oMT.1"
                     /locus_tag="IE325_RS05170"
                     /protein_end="255"
                     /protein_start="88"
                     /score="41.0"
                     /tool="antismash"
                     /translation="APLSPDARVMDGGSGRGGTAFLVNRRFGCEVVGVNFCAHHIEFAE
                     RLAKEKHGCDDKVSFKYANMCDTGLPADSFDAVYTNETTMYVDPAEAFAEFARVLRPGG
                     RYVCVTWCANDAVSTTSEAVKAIDDHYDCHINNRSDYFKALADNHLVPSQVWDLTQEAI
                     PHWE"
     gene            complement(10001..11038)
                     /locus_tag="IE325_RS05175"
                     /old_locus_tag="GCM10018780_10470"
     CDS             complement(10001..11038)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358733.1"
                     /locus_tag="IE325_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10470"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_190068439.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-55, bitscore:
                     184.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTHVTSSTRPQALFSPGVARSAVFPVMRHQVSTLEPSLARICGY
                     HLGFLDEHGDPASGGYGKLTRASLMMAVAEGVGLRPEDVRSQAAAVELLHNATLVHDDI
                     ADADDLRRGRRAAWKVFGTGQAIHAGNALQILGLRMVVDDSGPGHREIASTFTEAIGLV
                     HAGQARELTIRPGSDAGIAAYEQMVKEKASALLECSLATPAMRAERPENVLAALRDSGR
                     HLGIALQIFNDVEDIWGDPAVTGKPIRGDIRRRNPTFPVLVAMATDNPAANRLSRAWHA
                     ESTTDAHLQAMADLIDEAGGRHTAERLSRHHLDSAVEHLGRAGLSPTATTELTTLFDRI
                     VNRTT"
     gene            11389..11661
                     /locus_tag="IE325_RS05180"
                     /old_locus_tag="GCM10018780_10480"
     CDS             11389..11661
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE325_RS05180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10018780_10480"
                     /product="hypothetical protein"
                     /protein_id="WP_190068440.1"
                     /transl_table=11
                     /translation="MRAPTVLAAVALTGAVLFGGAGQALADDTDNTSSAGFDFGTSAPA
                     TPGSGQDEPSFGQDASGFGQDASGFGDDASGFGQDESGFGQSADD"
     gene            complement(11735..12394)
                     /locus_tag="IE325_RS05185"
                     /old_locus_tag="GCM10018780_10490"
     CDS             complement(11735..12394)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132714.1"
                     /locus_tag="IE325_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10490"
                     /product="response regulator transcription factor"
                     /protein_id="WP_190068441.1"
                     /transl_table=11
                     /translation="MIRVLVADDEPLIRAGIRMILTSADDIDVVAEAGNGREAVDLVRA
                     HTVDVALLDIQMPVLDGLSALAELRRAAPSVRPLILTTFGERENVLRALSHGGAGFLLK
                     DSAPGELIQAVRAAAAGDAYLSPAATRHVVDSLASGQAAARAEAARRRLESLSARELEV
                     LALLGEGLSNADAGERIHVSEATVKTYVSRILTKLECENRVQAALLARDAGLGTAP"
     gene            complement(12503..14206)
                     /locus_tag="IE325_RS05190"
                     /old_locus_tag="GCM10018780_10510"
     CDS             complement(12503..14206)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056317.1"
                     /locus_tag="IE325_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10510"
                     /product="sensor histidine kinase"
                     /protein_id="WP_229911668.1"
                     /transl_table=11
                     /translation="MARDVREHLVVAGMWSRRRIVGEAILAPFLALMATLGVLGDGVFA
                     IVAVAVVAVALSLLRRAFPTTVLVLTGAIAAVSGGFWALLMLAGWSAGPRIKAPRRALA
                     AFAISYALYAGLSALQEHSGLTAMQTLVFTTLAFLATTVVPGLAARYRTQRRTLMHALH
                     EHNAQLLREREIIASHTRLRERQRIAQDMHDSLGHQLALIAVHTGALEVDRTLTDGQRE
                     AVAVLRQASVAAMHELREAVGILRDGTYAQEHESESAAATRGVPGIDGLVEASRAAGAD
                     VKLRQEGETRSLAPAADHAAYRIVQEALTNALKHAQGASITVELRYEPDSLVVEVANGP
                     APVPADGGSRVVVSGGQGLTGLQERARLVGGMVHAGPVAGGGFRVAGVLPYSGRGGTPD
                     ASPTTFVDGGSDFRGQSERASNGDGGEVIDWSGSPDRQKELDRAMGNKKKGVVIGCGIA
                     AAVVVGLVVLAVVAVVALVNESDNAMIEPSVYKSMKVGEAEADVRDKLPDGDSFLTEGL
                     DSDGPAEPKGANCLVLMSTEIPDSLDDEPVFRFCFKDGKLIEKRSYTIKS"
     gene            complement(14304..15296)
                     /locus_tag="IE325_RS05195"
                     /old_locus_tag="GCM10018780_10520"
     CDS             complement(14304..15296)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662919.1"
                     /locus_tag="IE325_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10520"
                     /product="VOC family protein"
                     /protein_id="WP_190068442.1"
                     /transl_table=11
                     /translation="MNVFGSVRLGHIVIETNRFTDWRRFGTDAIGMHRDDLDTGLMRFR
                     LDDNQCRFLLRRGSAEDVVALGWHLADHTAFEQIEARVRAHGVPCVEGTAEEAGLRGVE
                     RLLRFPGPKGITQEICTAPVRSPQPLTMLTSGWVTGDAGMGHVAITSARPTLLRGYFTN
                     VLDARLTDVIEETISGVKLQIRFLRVNERHHSLAIAAVRGLPVDPVRTRVQHLNIQAAT
                     LDDLARSYDRVHELGFDMALTVGQHTNDKELSYYARTPSGFEWEVGWNSVVIDESTWEP
                     STHQGISIWGHTPVGQTIVGKLDQFRLAARSLARRERTVPALSGGAPLS"
     cand_cluster    14488..30723
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    14488..30723
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[24487:29766](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      24488..29766
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="2"
     gene            complement(15293..16129)
                     /locus_tag="IE325_RS05200"
                     /old_locus_tag="GCM10018780_10530"
     CDS             complement(15293..16129)
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-262). E-value:
                     6.8e-34. Score: 109.5. Matches aSDomain:
                     nrpspksdomains_IE325_RS05200_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549625.1"
                     /locus_tag="IE325_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10530"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_190068443.1"
                     /sec_met_domain="PF00561 (E-value: 7.1e-30, bitscore:
                     100.5, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.5e-26, bitscore:
                     88.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRESLIDVHGRRIFVTETGDGPPVLLLHGGGPGASGVSNYARNIA
                     ELAKEYRVIVPDLPGYGRSSKGVDRADPFGHLATGVRGLLDELGLDKAHLVGNSYGGAC
                     ALRLALDTPDRVDRMVLMGPGGIGTTRALPTPGLNSLLDYYSGDGPSRLKLERFIRTHL
                     VFNAADVPDSVIESRYRDSIDPEVVADPPLRRPKTLKALWRMDFTRDRRLSRLPVPTLV
                     LWGAADKVNRPSGGRMLADRMPNCDLYEVAGTGHWVQFERAELFNRMCADFLAGRR"
     aSDomain        complement(15344..16066)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS05200_Abhydrolase_1.1"
                     /evalue="6.80E-34"
                     /label="IE325_RS05200_Abhydrolase_1.1"
                     /locus_tag="IE325_RS05200"
                     /protein_end="262"
                     /protein_start="21"
                     /score="109.5"
                     /tool="antismash"
                     /translation="PPVLLLHGGGPGASGVSNYARNIAELAKEYRVIVPDLPGYGRSSK
                     GVDRADPFGHLATGVRGLLDELGLDKAHLVGNSYGGACALRLALDTPDRVDRMVLMGPG
                     GIGTTRALPTPGLNSLLDYYSGDGPSRLKLERFIRTHLVFNAADVPDSVIESRYRDSID
                     PEVVADPPLRRPKTLKALWRMDFTRDRRLSRLPVPTLVLWGAADKVNRPSGGRMLADRM
                     PNCDLYEVAGTGHWVQFER"
     gene            complement(16126..17691)
                     /locus_tag="IE325_RS05205"
                     /old_locus_tag="GCM10018780_10540"
     CDS             complement(16126..17691)
                     /EC_number="1.14.13.127"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837586.1"
                     /locus_tag="IE325_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10540"
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_190068444.1"
                     /transl_table=11
                     /translation="MTGTGEDAYDVAVIGYGPTGVTAANLLGAAGLKVVVLERDAEIYS
                     RARAISTDEEVLRIWQRTGLAERLKQDMLPDRPLDFVDARGRAFISARPTPRGHGHPPQ
                     MFLYQPALEQILRDGVDRYPEVEVLLRHECVRLRQEADGVELTVVGTADDAVRRLRAKY
                     VVAADGGSSLTRAQLNVGYEGRTYEDRWVVVDTRMIEPWPDHDRLRFRCDPARPAVDCP
                     TPLGHHRWEFPILPGDDETYLTTDDAIHSMVARYGIGPDQIEILRATVYSHHVRFAARF
                     RVGRVFLAGDAAHAMPPWIGQGMAAGVRDVANLCWKLEAVLRGELPESVLDSYEAERKP
                     HVKEVTARAVFVGRVITERRPAVTRLRDLLLPALNRVPGFGDWLQGSNWIPAAHYAEGL
                     QARPRAKASGHQLPQPRVTAPDGTRARLDDVLDGRWLLLHRGRLTPQPAWDRSGVPSLT
                     VLPAGSLPAEGAVVDDEGVLLPWLTEHRAAALALRPDAYVYAAAPAGAQLPPPPTGFTL
                     QGAS"
     misc_feature    17717..17734
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.38"
                     /tool="antismash"
     gene            17811..18458
                     /locus_tag="IE325_RS05210"
                     /old_locus_tag="GCM10018780_10550"
     CDS             17811..18458
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662910.1"
                     /locus_tag="IE325_RS05210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10550"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190068445.1"
                     /transl_table=11
                     /translation="MTRPRAARRMRANGVESRQRILDAAVEIAGERGYEGTSIAAVSAK
                     CGLPASSIYWHFEDKDHLIAAVIERSFAAWLTAVELPGPEAGTPLERVTAMAARVARSL
                     VEAPDFLRLGLMLALERRPAEPRGRAVFLQVRDLSRQRVADMIRALFPTLDEDVVHTLT
                     TYAVAGADGLFVHREIGGDSVDLVAMFELHARLVYEAARGMTPTHCPKEAKA"
     gene            18455..19504
                     /locus_tag="IE325_RS05215"
                     /old_locus_tag="GCM10018780_10560"
     CDS             18455..19504
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071159.1"
                     /locus_tag="IE325_RS05215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10560"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_190068446.1"
                     /transl_table=11
                     /translation="MTTAPRRIDVHQHLIPSLYRDALAASGITEAGGRALPDWSPEAAL
                     ESMDLLGTETAILSVSTPGTGFLTDPDEAAGLARRLNDHCAELTAQHPARFGWFATLPM
                     PDVAASAREAGRALAELGADGVTLLANNRGAYLGAEGQDALWEVLDEHGAVVFVHPAEL
                     PAPAVDGILPFAADFLLDTTRAAYLLVRNGVPRRYPNIRFILSHGGGFVPYASHRMAVA
                     IAGDIGRGPHDVLDDFRGFHFDTALSSSPAALPTLLAFARPGHVLFGSDWPFAPAAAGQ
                     YFAAGLDSGVDPDTLATINRTAAEALFPRLAGSRPAPPEPRPLAVRLRRSVRRAGARAV
                     FKLIQPGSD"
     gene            complement(19554..21734)
                     /locus_tag="IE325_RS05220"
                     /old_locus_tag="GCM10018780_10570"
     CDS             complement(19554..21734)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126615.1"
                     /locus_tag="IE325_RS05220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10570"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_190068447.1"
                     /transl_table=11
                     /translation="MEPTPGGLLSRAAHELGSRTDELTADVEQRLRRELPALWENPDVA
                     RTAAENVVEHTAAALFGIEHAIEPSLIELPPADVERARVLARHGTPLSTMLRAFRLAQE
                     IVSDRLFAELPRLSDDAEQVSVAARQLTALATTYVDRVAEQGVVAFQEERDRRLRWRSA
                     MVNEASMCIGTTLDIARTTQELADFAVQQFADLVTVDLLDTVLRGRDAAGEGPLMLRRM
                     AEGPTGGAGPEPAIAPRQLHTCPDGSPCAQALSSGRPSRQRQGGAWGAPSDGSTLVVPL
                     RARDTTLGVAQFHRYGPARHYDDEDLLLAQEIVARAAVAVDNARRYTHARATALTLQRS
                     LLPRAAPRQSAVDVAYRYLPAGSETGVGGDWYDVIPLSGARVALVVGDVVGHGIRAAAT
                     MGRLRTAVRTLADIDLPPDELLTHLDDVVLRLATEAGTDPDAEPEADVGRDNGATCLYA
                     VYDPVARRCTLARAGHVPPAVVVRDGTADVLELPPGPPLGIGGLPFEALEVDLPEGSLI
                     ALCTDGLIEARAAEGVDDVSPAPDTPAPDTPAPDTPDIEVGLTTLCRILARPAPSLETA
                     CDTVLEALLPSRPDDDIALLLARTRALGADRVVTWELDADPAVVARARADVSRQLAAWG
                     LEELAFVAELVVSELVTNAIRYGRSPISLRLIHDRALLCEVSDAGGTTPHLRRARVFDE
                     GGRGLLLVAQLAGQWGTRHARHGKTVWAALSE"
     gene            complement(21816..22538)
                     /locus_tag="IE325_RS05225"
                     /old_locus_tag="GCM10018780_10580"
     CDS             complement(21816..22538)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523020.1"
                     /locus_tag="IE325_RS05225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10580"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_190068529.1"
                     /transl_table=11
                     /translation="MLDKAATILESFSPSGGPYRLSELSERTGLPKATVHRLAADLVRL
                     GWLERSGTRYRLGAKLFELGSLVPHRLDLREAALPFLQDLFEATRETVHLGIREGMDVV
                     YLERIHGHEALQLPSRIGGSLPLTCTGVGKALLAFSGAELTEEVLSRPLPSLTPHSITD
                     PNRLRMALEKTRVSGLAYEEQEAALGVSCIAAPVFAGGTTVAALSVAVPRARFSPAQLA
                     PAVRTAALGLSRVLRGGG"
     gene            22705..23553
                     /locus_tag="IE325_RS05230"
                     /old_locus_tag="GCM10018780_10590"
     CDS             22705..23553
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070181.1"
                     /locus_tag="IE325_RS05230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10590"
                     /product="2-keto-4-pentenoate hydratase"
                     /protein_id="WP_190068448.1"
                     /transl_table=11
                     /translation="MPTAPDGVRPDAAPPAVVQAADLLAEAARTGAACPPVRELFDGGG
                     DLATAYAVQQLGVRRGLDAGRRIVGRKIGLTSVAVQRQLGVDRPDFGALFADMAVPDGG
                     EVAAGRLLQPKVEAEVALVLGRDLPERACTVVDVLRAVDFALPALEIVDSRIAGWDISL
                     VDTVADNASCGLYVLGATPVPLTAVDLRTVTMTMTRGGDSVSEGTGADCLGSPLNAAVW
                     LASTLAERGDPLRAGDLVLTGALGPMVPAVPGDVFEAHISGLGSVRVGFAKESAEEGGE
                     L"
     gene            23550..24491
                     /locus_tag="IE325_RS05235"
                     /old_locus_tag="GCM10018780_10600"
     CDS             23550..24491
                     /EC_number="1.2.1.10"
                     /GO_function="GO:0008774 - acetaldehyde dehydrogenase
                     (acetylating) activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552483.1"
                     /locus_tag="IE325_RS05235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10600"
                     /product="acetaldehyde dehydrogenase (acetylating)"
                     /protein_id="WP_190068449.1"
                     /transl_table=11
                     /translation="MSTKVAIIGSGNIGTDLMIKVLRLSESLEIAALAGIDPASDGLAR
                     ARRLKVATTHEGVEGLVALDEFADVEIVFDATSAGAHRHHDAVLRPLGRTLVDLTPAAL
                     GPYVVPPVNGDAHLDAPNVNMVTCGGQATIPIVAAVGAVTPVHYGEIVASLASRSAGPG
                     TRANIDEFTETTSSAIEQVGGAARGKAIIVLNPAEPPLIMRDTVHCLVSDCATEAVTAS
                     VEEMVGRVQAYVPGYRLKQKVQYERVAADDPLSTLAPSGGDLLKVSVFLEVEGAAHYLP
                     SYAGNLDIMTSAALRTAERMAARPIAPKVASR"
     gene            24488..25507
                     /gene="dmpG"
                     /locus_tag="IE325_RS05240"
                     /old_locus_tag="GCM10018780_10610"
     CDS             24488..25507
                     /EC_number="4.1.3.39"
                     /GO_function="GO:0008701 - 4-hydroxy-2-oxovalerate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009056 - catabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dmpG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009296206.1"
                     /locus_tag="IE325_RS05240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10610"
                     /product="4-hydroxy-2-oxovalerate aldolase"
                     /protein_id="WP_190068450.1"
                     /sec_met_domain="HMGL-like (E-value: 4.5e-60, bitscore:
                     199.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLYVQDVTLRDGMHAVRHRYTTGQARAIASALDAAGVAAIEIA
                     HGDGLAGSSINYGIGAHTDWEWIEAVVDVAHQAIPTTLLLPGIGTLHDLRQAHTLGIRS
                     VRVATHCTEADIAAQHMAAARELGMDVAGFLMMSHMAEPAELARQAKLMESYGAHCVYV
                     TDSGGRLTMDGVRDRFRAYRDVLSPETELGIHAHHNLALGVANTVVAVESGAVRVDASL
                     AGQGAGAGNCPLEAFIAVADLMGWDHMCELFPLMDAADDLVRPLQDREVRVDRETLSLG
                     YAGVYSSFLRHAETAAERYGLDTRGILVEVGRRRMVGGQEDMITDIALDLVARAGTVS"
     gene            complement(25560..26012)
                     /locus_tag="IE325_RS05245"
                     /old_locus_tag="GCM10018780_10620"
     CDS             complement(25560..26012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007496992.1"
                     /locus_tag="IE325_RS05245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10620"
                     /product="DUF6299 family protein"
                     /protein_id="WP_190068451.1"
                     /transl_table=11
                     /translation="MHLRPALATAVGAALLLLVAAPSAPADSDTKAEPEETVTVDTAAV
                     MAADGTVTVSGTYKCVDSAGPTFVSASVGQKASTNRYAIGGTVAECDGKEHRWQNKSKP
                     SPSTLKHGKADVEATIVELRPMDVLGGLPLPHFHAVLKKNVTLSKA"
     gene            26251..26448
                     /locus_tag="IE325_RS05250"
                     /old_locus_tag="GCM10018780_10630"
     CDS             26251..26448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973034.1"
                     /locus_tag="IE325_RS05250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10630"
                     /product="DUF5999 family protein"
                     /protein_id="WP_190068452.1"
                     /transl_table=11
                     /translation="MCSYQPSCPSSSDDRSAHVVAAHPEQGWSLLCSGAIVFDDSGELL
                     PDGRVVAPHRVPAARLAMAA"
     misc_feature    complement(26297..26311)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            complement(26456..26854)
                     /locus_tag="IE325_RS05255"
                     /old_locus_tag="GCM10018780_10640"
     CDS             complement(26456..26854)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523541.1"
                     /locus_tag="IE325_RS05255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10640"
                     /product="RidA family protein"
                     /protein_id="WP_190068453.1"
                     /transl_table=11
                     /translation="MSTERVNPPDLSPPTGFSHAVVATGSRVVFLAGQTALDSDGKVVG
                     ESLPEQFERALTSLLTALAAAGGTPADLARVTVYATDVAAYRAQAAELGAIWRKLAGRT
                     YPAMAVVGAVRLWDEAAMVELDGFAVLP"
     gene            complement(26851..27996)
                     /locus_tag="IE325_RS05260"
                     /old_locus_tag="GCM10018780_10650"
     CDS             complement(26851..27996)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432111.1"
                     /locus_tag="IE325_RS05260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10650"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_190068454.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 9.1e-12, bitscore:
                     41.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.3e-21, bitscore:
                     72.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.2e-46, bitscore:
                     154.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFSLDPAQTARCAELRTLAAERLRPLAEKGEPGHVNRPLVTEL
                     GRLGLLERLFTSGAVDLCLMRESLAHACTEAETALALQGLGAHPVHAYGTPAQRERWLP
                     GVAEGSTVAAFALSEPGAGSDAAALELRAEPEPAGDGGPVRWRLTGEKCWISNAPEADF
                     YTVFARTTPDAGARGVTAFLVPADRPGLTGTGLDMLSPHPIGALTFDAVPVTADDMLGE
                     PDRGFRVAMGTLNLFRPSVGAFAVGMAQAALDATLAHTAERDAFSGKLKDLQTVAHQVA
                     EMALRTEAARLMVYAAAAAYDEGSRDVPQRAAMAKLLATETAQYVVDKAVQLHGARALR
                     HGHLLEHLYREVRAPRIYEGASEVQRGIIAKELYATMEAGQ"
     gene            28153..29766
                     /locus_tag="IE325_RS05265"
                     /old_locus_tag="GCM10018780_10660"
     CDS             28153..29766
                     /NRPS_PKS="Domain: AMP-binding (52-436). E-value: 1.2e-79.
                     Score: 259.7. Matches aSDomain:
                     nrpspksdomains_IE325_RS05265_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997095.1"
                     /locus_tag="IE325_RS05265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10660"
                     /product="AMP-binding protein"
                     /protein_id="WP_229911654.1"
                     /sec_met_domain="AMP-binding (E-value: 6.1e-90, bitscore:
                     297.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGLHRSAHVDTFAREHLPPPEEWPELRFDLPGLHYPDRLNAAAE
                     LLDGPDDDRPVFHTPSGPTWTYGTLRAHVDRLAHVLTTHLGVVPGNRVLLRGPTTPWLA
                     ACWLAVLKAGAVAVTVLAQQRPHELRTMCEIAQVRHALCDIRAVDDLAKAEIPGLRLAT
                     YGGDAPDDLLRLPAPDTPYPAADTASDDVALIAFTSGTTGRPKGCMHFHRDVLAIADTF
                     SEHVLQPHMGDVFAGSPPLGFTFGLGGLVIFPMRAGASSLLLEQAGPKQLLPAIAEHRV
                     SVLFTAPTAYRAMLDELDSGDISSLRRCVSAGENLPAATWRAWHERTGLRVINGIGATE
                     LLHIFISAADEHIRPGTTGVPVPGWHARVVDAEGHDLPDGEPGLLAVRGPVGCRYLTDP
                     RQREYVRHGWNITGDTYVRESDGYFRYVARADDMIISAGYNIAGPEVEEALLRHPDVLE
                     TAVVGRPDEARGQVVVAYAVLREGARRDAEVLRTFVKAELAPYKCPREFVFLDALPRTA
                     TGKLQRFRLRDGGRPQGAQQ"
     aSDomain        28309..29460
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS05265_AMP-binding.1"
                     /evalue="1.20E-79"
                     /label="IE325_RS05265_AMP-binding.1"
                     /locus_tag="IE325_RS05265"
                     /protein_end="436"
                     /protein_start="52"
                     /score="259.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DRPVFHTPSGPTWTYGTLRAHVDRLAHVLTTHLGVVPGNRVLLRG
                     PTTPWLAACWLAVLKAGAVAVTVLAQQRPHELRTMCEIAQVRHALCDIRAVDDLAKAEI
                     PGLRLATYGGDAPDDLLRLPAPDTPYPAADTASDDVALIAFTSGTTGRPKGCMHFHRDV
                     LAIADTFSEHVLQPHMGDVFAGSPPLGFTFGLGGLVIFPMRAGASSLLLEQAGPKQLLP
                     AIAEHRVSVLFTAPTAYRAMLDELDSGDISSLRRCVSAGENLPAATWRAWHERTGLRVI
                     NGIGATELLHIFISAADEHIRPGTTGVPVPGWHARVVDAEGHDLPDGEPGLLAVRGPVG
                     CRYLTDPRQREYVRHGWNITGDTYVRESDGYFRYVARADDMIIS"
     CDS_motif       28729..28788
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS05265_0001"
                     /evalue="7.40E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IE325_RS05265"
                     /protein_end="212"
                     /protein_start="192"
                     /score="21.7"
                     /tool="antismash"
                     /translation="ALIAFTSGTTGRPKGCMHFH"
     gene            29782..30594
                     /locus_tag="IE325_RS05270"
                     /old_locus_tag="GCM10018780_10670"
     CDS             29782..30594
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122498.1"
                     /locus_tag="IE325_RS05270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_10670"
                     /product="PaaX family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_190068455.1"
                     /transl_table=11
                     /translation="MINVSDQHAPRSLIVTLYGAYGRHMPGPVPVAELIRLLAAVGVDA
                     PSVRSSVSRLKRRGLLLPARTAQGAAGYELSPDARQLLDDGDQRIYATVPPDDEGWVLA
                     VFSVPESERQKRHVLRSRLAGLGFGTAAPGVWIAPARLYEEARHTLARLRLAEYVDFFR
                     GEHLGFTPTVEAVARWWDLAAIAKEHDAFLDRHARVLHEWERRADTPPEEAYRDYLLAL
                     DSWRHLPYTDPGLPSRLLPEDWPGARSAAVFRGLHERLRDAGATYAGL"
ORIGIN
        1 cgatctccag ccggcgggcg cgcagtccca gcgactgcag gatctgcagg ccggtcttga
       61 cctcttcgac ggggggtgcg gtgagggaga cgcggatggt gtcgccgatg ccctcgttca
      121 ggaggatcgc gaaggcggtc gcggatttga cggtgccctg gggtggcggg ccggcttcgg
      181 tgacgcccag gtgcaggggg tagtcgcagg cggcggcgag gtggcggtag gcggcgacca
      241 tggtcatggg gtcgtggtgc ttgacggaga tcttcaggtc ggtgaagccg tgctcctcga
      301 acagggagca ctcccacagc gcggactccg tcagcgcctc gggggtggcc ttgccgtact
      361 tggccagcag ccgccggtcc aggctgcccg cgttgacacc gatgcggatg ggtaccccgg
      421 ccgcggcggc ggccgtcgcg atctccttga ccttgtcgtc gaaggccttg atgttgccgg
      481 ggttgacgcg gaccgcggcg cagccggcgt ccagggcggc gaagacgtag cggggctgga
      541 agtggatgtc ggcgacgacg gggatcttcg acttcgcggc gatcgcgggc agggcgtcgg
      601 cgtcgtcctg ggacggcacc gcgacgcgta cgatctcgca gccggccgcg gtcagttcgg
      661 cgatctgctg gagcgtcgcg tccacgtcgg cggtgggggt ggtggtcatg gactggacgg
      721 agaccggtgc gtcgccgccc accgggacac cggcgacatg gatctgccgg ctgctgcgcc
      781 gcgccggcgc gggcggaaca gcgggaaggg ggaggtccac ggctgtcatt gggggctccc
      841 accggtggag gcggtctgct tgaggggttt tccggcccgg gcgcgcagca ccgcgtgggc
      901 gatctgcgag ggcgtcaggc cggcgtcggc cagcagctgg tcgcgtgggc cgtgggtgag
      961 gaaggcgcgc ggcagcccca gattgtggac ggggacggtg atcgcgtggt cgcggagggt
     1021 ctgggcgagg gtgctgccga caccgccggt gcgggagttg tcctcgacgg tgactaccag
     1081 ccggtgccgg gcggccatgt cgagcagttc gggtgcgacg ggtgtcgccc agcgcgggtc
     1141 ggcgacggtc acaccgatcc cctgctcggt gagccgggcg gcggccttca ggcacatggg
     1201 ggccagcggg ccgtaggaga ccaggaggac gtcacggacc ccggactccg acaggacgtc
     1261 cacgctcccg gcgctgcgta cggccgccag gtcctgcccg gccctgccct tggggaagcg
     1321 gagggcggtg ggcccctcgt gcgcggtggc ttcccgcagc agcgaccgca gttggccgcc
     1381 gtcccggggc accgccagcc gcaggccggg cacgatgccg aggagggagg cgtcccacat
     1441 gccgtggtgc gaggcgccgt cgggtcctgt gatgccggcc cggtccagga cgaaggtgac
     1501 cggcagccgg tgcagggcga cgtccatgag gacctggtcg gcggcgcggg tgaggaaggt
     1561 ggagtagagg gcgacgacgg ggtggaagcc gcccatggcc agtccggccg cggaggtgac
     1621 ggcgtgctgc tcggcgattc cgacgtcgaa gacccgctcg gggtacttca ccgccatcga
     1681 atacaggccg gtggggcgga gcatggaggc ggtgatggcc accaagtcct cgcgttcacc
     1741 ggccagttcg agcagggcct gcccgaagag gctggtccac gacacggcgg gcggcccgga
     1801 ggcgggggcg ggtgcgggca tgccggtggc cgcgtccacg gtgcccaccg cgtgcagaca
     1861 gtcggcctcg tcgtcctcgg ccggcgcgaa tccccagcct ttgacggtca ccgcgtggac
     1921 gagtacgggc cggcgcaggc ggcgggcctg ctccagtacg gcctccaggg ccgcggtgtc
     1981 gtggccgtcg acggggccca ggtaggtgaa gccgatccgg gtgaacagat tcgcgcccgc
     2041 cccgtccgat acggccccgg agtgcttcag ggcgtccagt tggttggtga gggcgccggt
     2101 ggtgggggcg taggagcggc cgttgtcgtt gaggaccacg acgaccggga gctccccggc
     2161 gccgatgttg ttgagcgctt cccaggccat gccgccggtc atggctccgt cgccgatgac
     2221 ggcgaccacc gaccggtccc ggtgtccgcg cagttcatgg gccttggcca ggccgtcggc
     2281 gtaggagagg gaggcggagg cgtgggagtt ctcgctccag tcgtgcgcgg actcggcgcg
     2341 cgagggatag ccggagagtc cgccggcctg gcgcagccgg tcgaagtcgg cggcgcgtcc
     2401 ggtcaggatc ttgtggacat aggcctggtg gccggtgtcg aagaggatcg cgtcgcgtgg
     2461 tgagtcgaag acgcggtgca gggcgatggt cagttccacc atgcccaggt tggggcccag
     2521 atggccgccc gacgcacaga ccttctcgat gaggaacgta cggatgtccc gggccagggc
     2581 ggcgagttgc ccggccggca gggcacgcac gtcgtggggg ccgccgagcg tggtcaggtc
     2641 cgggcttcgc gggcgaccgg tccgtgcggt gggcgcgggc ggtgccgggt gggtgtcgtg
     2701 gcagggcagt tgtggtgggg gcatgagcat ccttccgccg cagacgagcg cagcaggtgg
     2761 tcgcaaggac tgtggtggct gcgtggctgt cgtggggggg gagcgggaca cccgcccggc
     2821 cgagccggcg gccgacggcc gggtcgcccg ccgggccgcg gcagctacga gcccgagacc
     2881 ctcgccttcg gcagtgcccg cagggtcgat tcggccttga gcagcatttc ctcgtactcc
     2941 gcgtcgggat cggagtcgag gacgatggct ccacccgcac cgatggtcag ttcgccgtcg
     3001 tggctcaccg cggtgcggat gacgatgctg aggtcggtgg tcccggtgta tccgatgaaa
     3061 ccgagggctc cggaatagac tccgcgggcc tcaccctcca aggtgtcgat gatttccatg
     3121 gtgcgcagct tcggtgctcc cgtcatggat ccgccgggaa agcaggcgcg tacggcgtcc
     3181 acggcggact ttccgtcgcg cagggtcccg gtgaccgtgg agaccaattg gtgcacggtg
     3241 gcgtacgact ccgtcgccat cagcgagggg acggtgacgc tgccgacctc gcagatccgt
     3301 ccgaggtcgt tgcggagcag gtccacgatc atgaggttct cggcgcgcgt cttgggatcc
     3361 atctgcaatg agcgccgcct ctcgtcatcg gttcgtggat ccgggtgacg gggcgctgtt
     3421 cctttgatcg gtttggtctc caccgtgcga gcggcgtcca ccttgaggaa tcgctcgggt
     3481 gacgagctga ggaccgtgac ctcgccgagg cgcaggaatg cggcgtaggg agcggggttg
     3541 aggcggcgca ggcgctggta ataggcgaag tcattggccg gcgcgggcag atggagttta
     3601 ttggtgaggc atatctcgta gctcacgccc tcccgcagtc ggcgatcgca ctcacggatg
     3661 tcggcgaggt actgggtgcg cgatcgggcc agtcgccgcg acgcctcatg gttctcggcg
     3721 cggggtggtg gagacgtgtc ggactgggcc gtgggcagct cggccaggac ggggatgacc
     3781 gtactgatcc atttctcggc ggcgaccagg tcctgctgct cgcacacggc gacgatgtac
     3841 gtgcggttct cggcgtggtc cacggcgatg aaacggtcgg cttgaagcca cacggcgtcc
     3901 ggggtcttcg accggtgcgg gtgctgggcg ccgagatcgg ccttcaattc atagccgaaa
     3961 tagccgacgt agccgccgag gaaatcgaag ggcaattcct cggctccctc gaccattcgg
     4021 ccggtgcggc ggtcgagggc gtcgaagatc gtgccggtct ccagacgggg aacgcctccc
     4081 gcgggatcca cgacgacatg cttgtcctcc acccggtagg tgagcatctc ggctccgggc
     4141 gccgccgcgg agccgaagaa ggagaagcgg gccagcccgg gttcgacatg tgagctgtcg
     4201 agccagaagg agcgtgcgtc ggcgccgtac agggcctgga acgcggcctc ggtgtcgacg
     4261 gctcggtcca gggtgccgat ctgcgcctgg agtcgcacgg ggcgcgggag cggggtcgtc
     4321 ggtgcgtcgg acacgcgtac gccattggtg ccgatgccgc cgccctggcg ggtgcccggg
     4381 gcgagggcca ggtcacggaa gttcgccacg aggagggcgc cgtgctccgt gcagatcgac
     4441 tccgggtgga actgcacgcc ccaccagggc cgatcgcggt gggccaggcc catgaccacg
     4501 ccgtcctcgg cgcgggcggt gatctccagg tgggcgggca cgggttccgc gatgctcagc
     4561 gagtggtagc gcacggcggt gaactcctgc gggatgcccg cgaagaggcc gtcgccgctg
     4621 tgccggatcg tggacaggtg gccgtgccgg ggctgcggtg ccggggtgat ccgcgcgtcc
     4681 gccagcagtc ccatgccctg gtgtcctagg cacacgccca ggaccggaag ccgggtgtcc
     4741 gccaggatgt cgcgggagcg gccgaagtca cgggggacgg ccgggtgccc gggtcccggt
     4801 gagatgaccg cggcatcgaa gccgtccaga tcgaggtggc tccaggccgc agcatcgttc
     4861 cgtacgacga cgggcgtgct gccgtacacc ttcgccagga gctggtacag gttgtaggtg
     4921 taggagtcgt aattgtcgat gagcagcacg cgcatgagtc aacaccaggt ggttgtcgga
     4981 ggcggaggaa tggagagtgc gggaatctcc cggtgcgcag cgtgaggggc gggcgtcagg
     5041 gggtttcggt cttcaccgtc gaccagtcga aggggaccga gtcgaataca tccagttcct
     5101 ggcacaactg ccgcaatccg ctgaagtcct gaaggagccg cccgctgccg gaggtgttct
     5161 tgatgtcgcg cagcatctcc gcgcctccct ccacttcgag caattccatg atccgcgccc
     5221 aggtcgtgaa gtcatgggcg gcgaacgcct ccatcccgtc ggccagttcg gtcaggaagc
     5281 agccgcgctg ttctgcggtg aatcgcttcc atgcttcttg gacgacggtg ttggcgatcg
     5341 aggcgtgaca gtattcgtcg cggttgtgca ggacggccgt catgcggttg acgggctgga
     5401 tctcgtggtc ctccgcgatg aggtccagat gggcgttgat ggagatttcc gcgaccgtgg
     5461 tgaaggcgag tgagaccagc gcctgctgct caggggtttc ggcggcggcg agccggtgcg
     5521 tatgccggcg tgtcttgtag ccgcggggaa gcgcggtctc gggcatacgc cagccgcgtt
     5581 gccgacgcgt caccgcgctg gcgttcagat gcatcagcgt gtggtactgc tcgtcgacca
     5641 tggcctgtgt gaccgcgatg gtcatggaat cgcccagccc tgtaccgaag gcgtccttgg
     5701 cgatcagact gaaccccggg ttgaccacga actgctcgat gtccatgacg ttcttgttga
     5761 acgccaccca gccccacgcg agaagcctgg ccttgatttc gtcgtcgaga ccgagatagg
     5821 tggggtgatt ccggaaaggc agcagggcca ctggaaagtc cggcctgtcc cgctcgaaca
     5881 cgtcgtccag ggtctcctcc cgccgcttca ccgtggcgcg ccggtaccag ttgtcggcga
     5941 gcctgctgat gacggcgttc tccaccgggt cattcggatc gtgttccggg agcgaccgca
     6001 gccgttccgc cacgggcaat gccccgaact ccccttcatc gagcatctcg tccatagtga
     6061 tccttatggt ccaaggtgat cccgaagatc ttcccgggag cggaaagtgc ctcgtcgtcg
     6121 tcgagttccc ggaaggtcgc cggctctccg ggccgtattt ccgtgagggt gttgccgatg
     6181 aggacgtgcc gcaccttcgg ctgagtgcgc tggaggatca cccggtggtt gaacggtgag
     6241 cgagggtggg tcaggcagta gtggttcagg acctcgaagt ccgccggata gcgcgcgtcg
     6301 gtggtgaatc cgtagagttc cgccggtccc tcggcccgca ggaatcgcag tacgtattcg
     6361 ccgtgcggtt cccgcaccac atcgaaaggc caatcgccgt ccagccgggc gccctcggcg
     6421 aggcggatcg gctcatgcag cccgtatccg ccgaaactca cgtcgaagag ccaccgttcg
     6481 tcgtccagcg tgacgcacag ggcgatatgg acggcgggac ccaacttgtt tccggtgcgg
     6541 atccgggagc gggccgcgaa cgccgagaag gtgaacccga tccggtccag cacggccgcc
     6601 atcaggacga cctgttccag acacaggccg ccacggccac gtcgaacgat cttctcctgg
     6661 acgctgtcca ggtccaacgg caccgcccgc ccgagcaccg cgtcgatgtt ctcgaaggcg
     6721 atcgcctcga catgagcggc atgcaggccc cgtagcgtgc cgagatccgg agccacttcg
     6781 gcctcgtatc ccacacggga gagataggcg tccaggtcta catcggcgcc ctgccatatc
     6841 gaatctgtca ttgtatccca tccttcgatc cgcggattca gctctgtcag gtgaactgtc
     6901 cggcgatcgt cgccgcgaga atgatccagc cgaagtagcg gttggtgacg aaggtgtccc
     6961 agcaggattg cggatcgtcc aggttcactc gtacgacctg ataggacagc agcgcccccg
     7021 cacccacgac gagcgggtag aaggcccagc ccgtctccgc ctcgataccg gcccacaaag
     7081 cgccggcgac gctcagcacg atgaagacgg tcagccatgc cttgctggat tcgccgaaca
     7141 tcagagcaga ggacttgacg ccgatgctcc ggtcgtactc cttgtcctgg tgggagtaga
     7201 cggtgtcgtg gaaaagggtc cagaagaaag cgcaggcgta aaggccgtac acggtaggcg
     7261 gatagtccac gctcccggtc accgccgtcc agcccgccat cggatagacg ctgatcacca
     7321 acgccagcca tgccgtgggc cacggagata tgcgcttcat gtaggggtac gcgacaagga
     7381 acggatacga ggcgcccacg accagcgccg tttccgtgtt gatcagcgcc aggatcgcaa
     7441 gagaagccac agcctgtgcg gcgccgaaca gcagagcctt tccgacactg atcgtgccgg
     7501 cggcgacggg acgcgacgcc gtgcgggcga cctgggcgtc gatgtccttg tcgacgacgt
     7561 cgttgaccgc gcagctcgct ccccgtacca gtacggccgc gagggcgagc cataccaccg
     7621 ccagcagatc cgggcgttgc tcggtggcga gggtgagact ccacaatcct ggaaggaggt
     7681 agagcacgac gcctgtgggc gcgtggagcc gcatcaatat gagataggag cgaatcgaat
     7741 ccgggctctt cttgaccatg tgcgcggata tccgctgcag catgggggaa ttgtcgcggc
     7801 tcaccgccgc cggggtgctg ctcaccacgt caccggaagt tcgaccaggc cgccgagcaa
     7861 cgtgtcgtga cgcagtttca gttccgccac gtcgacggcg agccgcatgg tcgggaagcg
     7921 tgcgacgagt cgggcgagcg ccacctggag ctgcatccgg gccagcgggg cgccgacaca
     7981 gtagtgcgtg ccatggccga aggtgaggct gcccgcggtt tcgcgggtga catcgacccg
     8041 ctcggggtcg gtgaacaccg tctggtcgtg gttggccgcg atgatgttca gcagcacgag
     8101 ttcgccggtc cggatggtgg ttccgtcgat ctccaggtcc gtcagcgcat agcggggcat
     8161 tccgccgttg tgcgggttcg gcatcgaccg acggaggatt tcctccaccg cgcccgggac
     8221 gaggcccggg tcatccagca aagcctgccg ttgctcgggg ttggtcagca gcagcaacgc
     8281 tcccgtgccg atgcgggcca ccgtggtctc gtatccgccg aacagcaaca acgcggtcag
     8341 gcccacgact tccgtgtcgc tgatgccctc ggtcgcgcac agcctggaga tcgcgtcgtc
     8401 gccggggttc tgccgcttgt gcgcgatgag tttctggcag tagccgaaca gctcggccat
     8461 gccttgcttg gatcggatcc ggtcccccac attggcggcg tcctgggtcc agctgccgaa
     8521 ccggtccttg tcctcgtggg gcacgccgag ccattcgcac atcaccagaa tcggcagcgg
     8581 taatgccagt gcctggcgca gatccaccgg cggcgcctgc ccggccaact cgtcgagcag
     8641 ccgctcggtg agtgtctcga cgtgggagcg cagcgcccgc atgcgctcgg gtgcgaagtg
     8701 cggctccagc agcgcacgca gccgggcgtg gtcggtggcg aagccgccca gcaggctgtc
     8761 gagcagcgcg gccccgctgt ctcgggccgc gcccgggtcg ggattggagc ggctgagccg
     8821 gtcgtcgtcc aacaaccgct gtacctcggc atggccggtg accagccatg cctcgtcccc
     8881 ctcgggggta cgaacgcgat ggaccgtgcc ctcggactgg agcgtgcgca gcagtggcgc
     8941 gacatgcaac aggtgcgtct gctcgaaggg caattgagct ggtgcgttca ctgacaacct
     9001 ccacatcgtt gtgacccggc cctggcgggc gggcgccact cgggcgaggg cacccgccgt
     9061 gcgcgatgag ggcgactacg ccggcggcgt gtactcggcg accacgacta tgtagttgag
     9121 ttcgttgctc cggtgcgcgt cgaggaacgg ctgctccaca ccggtggcca ggccccagtg
     9181 ggatcgcagc tcccagtggg ggatggcctc ctgggtcagg tcccagacct gcgagggcac
     9241 gaggtggttg tcggcgagcg ccttgaagta gtcgctgcgg ttgttgatgt ggcagtcgta
     9301 gtggtcgtcg atggccttca ccgcctcgct ggtggtcgac acggcgtcgt tggcgcacca
     9361 ggtgacgcag acgtagcggc ctcccgggcg cagcacccgg gcgaactccg cgaaggcctc
     9421 cgcggggtcg acgtacatgg tggtctcgtt ggtgtacacg gcgtcgaacg agtcggcggg
     9481 cagaccggtg tcgcacatgt tggcgtactt gaaggacacc ttgtcgtcgc agccgtgctt
     9541 ctccttggcg aggcgctcgg cgaactcgat gtggtgggcg cagaagttga ccccgaccac
     9601 ctcgcacccg aaccgccggt tgacgaggaa ggccgtgccg ccgcggcccg atccgccgtc
     9661 catcaccctc gcgtcgggcg agagcggggc cagcccgtgc agtaccagct cgacctgctc
     9721 gttctccatg cgggtcatct ccgcgaggat cgccgcgtcc cgctcgggcc ggggaacctc
     9781 cagcacggac ttgtcgtagg gaccgacggc gtagtggtgg tggtacagcc cgtcctcctc
     9841 gcccagcagc aggttgatcg ggtcctgggt cttggtctcg tagtgagcct gcgcccggcg
     9901 ctcgaactcg ctgcggatga cggggcgaac cgaggtgtcc tgggtggtgg tcatgatggt
     9961 gaactccaat caacatgccg cttctgtggg gcggcgcggg tcatgttgtg cgattgacga
    10021 tgcggtcgaa cagcgtggtc agttcggtgg tcgcggtcgg ggacagtccg gctcgtccga
    10081 ggtgttcgac agccgagtcg agatggtggc gggacagccg ctcggccgtg tgccggccgc
    10141 cggcctcgtc gatgaggtcg gccatcgcct gcagatgcgc gtccgtggtg ctctcggcgt
    10201 gccacgcacg gctcagccgg ttcgcggccg ggttgtcggt ggccatggcg accagcacgg
    10261 ggaaggtcgg attacgccgc cggatatctc cccggatcgg ttttccggtc accgccggat
    10321 cgccccagat gtcctccacg tcattgaaga tctgcagagc gatgcccagg tgccggcctg
    10381 aatcacgcag cgccgccagg acattttccg gccgttccgc gcgcattgcc ggcgtcgcca
    10441 gtgagcactc cagcagtgcc gaagccttct ccttcaccat ttgttcgtac gccgcgattc
    10501 cggcgtccga accgggccga atggtgagtt cgcgagcttg acccgcgtgc accaatccga
    10561 tggcctcggt gaacgtactg gcgatttccc tgtggccggg tccggagtcg tccacgacca
    10621 tccgcagccc gagaatctgc agcgcgttcc cggcgtgtat cgcctggccc gtgccgaaca
    10681 ccttccacgc cgcccggcgg ccgcggcgca ggtcgtccgc atcggcgatg tcgtcgtgca
    10741 ccagcgtcgc gttgtgcagc aactccaccg ccgccgcctg ggaccgtacg tcctccggcc
    10801 gcaggccgac cccttcggcc accgccatca tgaggctggc gcgggtgagt ttgccgtatc
    10861 ccccacttgc ggggtcacca tgttcgtcga ggaaacccag gtgataaccg cagatccggg
    10921 ccaaggaggg ctccagcgtg gaaacctgat gccgcatcac aggaaatacc gcggatcgcg
    10981 ccacccccgg cgaaaagagg gcctggggcc tggtggacga ggtgacgtgc gtactcatcg
    11041 cgattctcct ccagtcgcgc gagcaaatcc gattcccgat ttcggatttg agtctgggtg
    11101 atctcgctca gcggcgtcaa cgaggcatcg atgaggacta gggaaaccac taggggggcc
    11161 actaaggaat tcactagggg cgctggaggg cactaaggaa atcactagga gagtcaccac
    11221 gggcgtcatg acggggggca ccaagcgggt caccgaaagc gatgcggtgc gagcccgggt
    11281 gcgtcatgtg cgccacctgt tcgggtgctt gtgtgcacgc caccgctact cgtgcgtggg
    11341 tcgacggcat acctctgggc gagcacacac ctaccgaagg agacgctcat gcgtgcaccc
    11401 accgtgctgg ccgccgtcgc tctcaccggg gccgtcctgt tcggcggcgc gggccaggcc
    11461 cttgccgacg acaccgacaa cacgagcagc gccggattcg atttcgggac cagcgcaccg
    11521 gccacgcccg gctccggcca ggacgagccc agcttcggcc aggacgcctc cggcttcggc
    11581 caggacgcct ccggcttcgg cgacgacgct tccggcttcg gccaggacga gtccggcttc
    11641 ggtcagtccg ccgacgactg atcgccgcgc cacggttgtc gttccccgcc ccgcaccgtc
    11701 gaccttcgtg tcctcggtgc ggggcgggtg cgattcaggg cgccgtcccc agccccgcgt
    11761 ccctggccag cagcgcggcc tggacccggt tctcgcactc cagcttggtc aggatgcggc
    11821 tgacgtaggt cttcaccgtg gcctcgctga cgtggatccg ctcgccggcg tcggcgttcg
    11881 agaggccctc gccgaggagg gcgaggacct ccagttcgcg ggcgctgagg gattcgaggc
    11941 ggcgccgggc cgcttcggcg cgggcggctg cctggcccga ggcgagggag tcgacgacgt
    12001 gccgggtggc ggccggcgac agatacgcgt ccccggccgc ggcggcccgt accgcctgga
    12061 tcagttcgcc cggtgccgag tccttgagca ggaagcccgc gccgccgtgg ctgagggcgc
    12121 gcagtacgtt ctcgcgttcg ccgaaggtcg tcaggatcag cgggcgtacg gaaggtgcgg
    12181 cccggcgtag ttcggcgagg gcggagaggc cgtcgaggac cggcatctgg atgtcgagca
    12241 gggcgacgtc gacagtgtgc gcccggacca ggtcgacggc ctcacgtccg ttgccggcct
    12301 cggccacgac gtcgatgtcg tcggcggagg tgaggatcat cctgatgccc gcccggatga
    12361 gcggttcgtc atccgcgacg aggaccctga tcacaactct cccgcaggct ttcgtgaacg
    12421 cgtggctttc ggtggacgca tgacgttcgg tggacgcgtg gaacgcgaca accatactca
    12481 cggccccggc acctgacgtt cgctacgact tgatcgtgta ggaccgcttc tcgatcagct
    12541 ttccgtcctt gaagcagaac cggaagacgg gttcgtcgtc caggctgtcc ggtatctccg
    12601 tcgacatcag caccaggcag ttggcgccct tcggttccgc cggtccgtcg ctgtccagcc
    12661 cctcggtgag gaaggagtcg ccgtccggga gcttgtcgcg tacgtccgcc tcggcctcgc
    12721 cgaccttcat cgacttgtag acggacggtt cgatcatggc gttgtcgctc tcgttcacca
    12781 gcgcgacgac ggccacgacg gcgagcacca ccagaccgac gacgacggcc gccgcgatgc
    12841 cgcatccgat cacgacgccc ttcttcttgt tccccatggc gcggtcgagc tccttctgtc
    12901 tgtccggcga tccggaccag tcgatgacct caccaccgtc gccgttcgac gccctctcgc
    12961 tctgcccccg gaagtcgctg cccccgtcta cgaaggttgt cggcgaggca tccggcgtac
    13021 cgccccgccc gctgtacggc agcacacccg ccacccggaa gccgcccccg gccacgggcc
    13081 cggcgtgcac cattccgccg accagccggg cgcgttcctg cagcccggtc agcccctgcc
    13141 caccgctcac cacgacccgc gaaccaccgt cggccggtac cggcgcgggg ccgttggcga
    13201 cctcgaccac cagcgagtcc ggctcgtacc gcagttccac ggtgatcgag gcgccctggg
    13261 catgcttcag ggcgttggtc agggcctcct gcacgatcct gtacgccgcg tggtcggcgg
    13321 cgggtgcgag tgaccgtgtc tcgccctcct gtcgcagctt cacgtccgca cccgcggccc
    13381 gcgacgcctc caccaggccg tcgatgcccg gtacgccccg ggtcgcggcc gccgattcgc
    13441 tctcgtgctc ctgcgcgtag gtgccgtcgc gcaggatgcc gacggcctcg cgcagttcgt
    13501 gcatcgcggc cacggaggcc tgccgcagca ccgcgaccgc ctcgcgctga ccgtccgtca
    13561 gcgtccggtc cacctccagc gcgcccgtgt gcaccgcgat cagcgccagc tgatggccga
    13621 ggctgtcgtg catgtcctgg gctatccgct gccgctcgcg cagcctggtg tgggacgcga
    13681 tgatctcgcg ttcgcgcagc agttgggcgt tgtgctcgtg cagcgcgtgc atgagggtgc
    13741 ggcgttgggt gcggtagcgg gcggcgaggc cgggcacgac ggtcgtcgcc aggaacgcca
    13801 gtgtggtgaa caccagcgtc tgcatcgcgg tgagcccgga gtgttcctgg agggcggaca
    13861 ggcccgcgta gagggcgtac gagatcgcga acgccgcgag cgcccgccgc ggtgccttga
    13921 tcctcgggcc cgccgaccag ccggcgagca tcagcagggc ccagaatccg ccggacacgg
    13981 cggcgatggc gccggtcagc acgagaacgg tcgtcgggaa cgcccgccgc agcagggaca
    14041 gcgcgacggc gaccaccgcc accgcgacga tcgcgaacac gccgtcgccc agcacgccca
    14101 gggtcgccat cagcgccagg aagggcgcca ggatcgcctc gccgacgatc cgccgccggg
    14161 accacatccc cgccacgacc aggtgttctc ggacgtctcg cgccatcgtc gtcagattca
    14221 cacgccaacg gtagggggcg gcgccccggc ccacagcatc cgttcgtcgc accggtgtac
    14281 gacgaaagtc gcatccggcg cgctcaggag aggggcgcgc ccccgctgag ggcggggacc
    14341 gtccgttccc ggcgggcgag ggagcgggcg gcgaggcgga actggtcgag cttgccgacg
    14401 atggtctgcc cgaccggtgt gtggccccag atgctgatgc cctggtgggt gctgggttcc
    14461 caggtgctct cgtcgatgac gacggagttc cagccgacct cccactcgaa gccggagggc
    14521 gtgcgggcgt agtaggagag ttccttgtcg ttggtgtgct gtccgaccgt gagggccatg
    14581 tcgaagccga gttcgtgcac gcggtcgtag ctgcgggcca ggtcgtcgag tgtggcggcc
    14641 tggatgttga ggtgctggac gcgggtgcgg accgggtcga cgggcaggcc ccgtacggct
    14701 gcgatcgcga gggagtggtg gcgttcgttg acgcgcagga agcggatctg gagcttgacg
    14761 ccgctgatcg tctcttcgat gacgtcggtg aggcgggcgt cgaggacgtt ggtgaagtag
    14821 ccccgcagga gggtgggtct cgcggaggtg atggccacgt ggcccatgcc cgcgtcgccc
    14881 gtgacccagc cggaggtgag catggtcagg ggctggggcg agcggaccgg ggcggtgcag
    14941 atctcctggg tgatgccctt ggggccgggg aaccgcagca ggcgttccac gccacgcagc
    15001 cccgcctcct cggcggtgcc ctccacgcag ggcacgccgt gggcgcggac ccgggcctcg
    15061 atctgctcga aggcggtgtg gtcggcgagg tgccagccta gggcgacgac gtcctcggcg
    15121 gacccgcgcc ggaggaggaa gcggcactgg ttgtcatcca ggcggaagcg catcaggccg
    15181 gtgtcgaggt cgtcgcggtg catgccgatc gcatcggtgc cgaagcggcg ccagtcggtg
    15241 aagcggttgg tctcgatgac gatgtggccg agacggacgg agccgaagac gttcatcggc
    15301 ggcccgccag gaagtcggcg cacatccggt tgaacagctc ggcgcgctcg aactgcaccc
    15361 agtgcccggt gcccgcgacc tcgtacagat cgcagttggg catacggtcg gccagcatcc
    15421 ggcccccgga cggccggttc accttgtcgg ccgcgcccca gagcaccagc gtgggcaccg
    15481 gaagccggga cagtcgccgg tcgcgggtga agtccatcct ccacagggcc ttcagcgtct
    15541 tcgggcgcct cagcggcggg tccgcgacga cctccgggtc gatgctgtcc cggtagcgcg
    15601 actcgatgac gctgtccggc acgtccgccg cgttgaagac gaggtgggtg cggatgaacc
    15661 tctccagctt cagccgcgaa ggcccgtccc cggagtagta gtcgagcagg ctgttcaggc
    15721 cgggggtcgg cagcgcgcgg gtggtgccga tgccgccggg gcccatcagg accatgcggt
    15781 cgacccggtc gggggtgtcc agggcgaggc gcagggcaca ggcgccaccg taggagttgc
    15841 cgaccaagtg cgccttgtcc aggccgagtt catcgagcag accacggacg ccggtggcga
    15901 ggtgaccgaa ggggtcggcg cggtccacgc ccttgctgct gcggccgtag ccgggcaggt
    15961 cggggacgat gacgcggtac tccttggcca actcggcgat gttccgggcg tagttggaga
    16021 ccccggaggc gccggggccg ccgccgtgca gcagcagtac gggcggtccg tcgccggtct
    16081 ccgtgacgaa gatccggcga ccgtggacat cgatcaggga ctctctcatg acgctccttg
    16141 gagggtgaat ccggttgggg gcggcgggag ttgggcgccc gcgggggcgg cggcatagac
    16201 gtacgcgtcg gggcgcagcg cgagggcggc ggcacggtgc tcggtcagcc acggcagcag
    16261 cacaccctcg tcgtccacga ccgcgccctc cgccgggagc gagcccgccg gcaggaccgt
    16321 cagggagggg acaccggagc ggtcccacgc gggctgcggg gtgagccgtc cgcgatgcag
    16381 cagcagccac cgaccgtcga gtacgtcgtc caggcgggcc cgcgtgccgt cgggggcggt
    16441 gacccggggc tgaggcagct gatgcccgga ggccttggcg cgagggcggg cctggaggcc
    16501 ttcggcgtag tgggcggcgg ggatccagtt ggagccctgg agccagtcgc cgaagcccgg
    16561 gacccggttc agggccggaa gcagcaggtc ccggagccgg gtgacggcgg gccgccgctc
    16621 ggtgatgaca cggccgacga acaccgcccg cgcggtgacc tccttgacgt gcggcttgcg
    16681 ctcggcctcg tagctgtcga gcaccgactc gggcagctcg ccgcgcagca cggcctccag
    16741 cttccagcac aggttggcca cgtcacgcac cccggcggcc atgccctgcc cgatccacgg
    16801 cggcatcgca tgggcggcgt caccggcgag gaagaccctg cccacccgga agcgggcggc
    16861 gaagcggaca tggtggctgt agacggtggc gcgcaggatc tcgatctggt ccgggccgat
    16921 cccgtaccgc gccaccatcg agtggatcgc gtcgtcggtc gtcagatagg tctcgtcgtc
    16981 gcccggcagg atcgggaact cccagcggtg gtgaccgagc ggggtcgggc agtcgaccgc
    17041 cgggcgggcc gggtcgcagc ggaagcgcag ccggtcgtgg tccggccagg gctcgatcat
    17101 cctggtgtcg acgacgaccc agcggtcctc gtacgtccgt ccctcgtacc ccacgttgag
    17161 ctgcgcacgg gtgaggctgg agccgccgtc ggccgcgacg acgtacttgg cgcgcagacg
    17221 tcgtacggcg tcgtcggcgg ttcccacgac ggtgagctcg accccgtccg cctcctggcg
    17281 cagccgcacg cactcgtgcc gcagcaggac ctccacctcg gggtagcggt cgacgccgtc
    17341 gcgcaggatc tgctcaaggg cgggctggta gaggaacatc tgcggcgggt ggccgtggcc
    17401 gcgcggggtg gggcgggcgc tgatgaaggc gcggccgcgc gcgtcgacga agtcgagcgg
    17461 ccggtcgggg agcatgtcct gcttcagccg ctcggcgagg ccggtgcgct gccagatccg
    17521 caggacctcc tcgtcggtgg agatcgcgcg ggcccgcgag tagatctcgg cgtcgcgctc
    17581 cagcacgacg accttcaggc cggccgcgcc cagcaggttc gcggcggtca ctcccgtggg
    17641 gccgtagccg atcaccgcca cgtcgtacgc atcctcgccg gtccctgtca tcggcccacc
    17701 tcactgtcgt cccggattct taccgtagtg ttcactccaa ttggaatgga cgctacggta
    17761 agctcggctt cagggtcggt caagtgccgg accgacagga aggggcgccg atgaccaggc
    17821 ctcgggcggc gcgcaggatg cgggcgaacg gcgtggagtc gcggcagcgc atcctcgacg
    17881 ccgccgtcga gatcgcgggc gagcgcggct acgagggcac gtcgatcgcg gcggtcagcg
    17941 ccaagtgcgg gctgcccgcg tcctcgatct actggcactt cgaggacaag gaccatctga
    18001 tcgccgcggt catcgagcgc agcttcgcgg cctggctcac ggccgtcgaa ctgcccggcc
    18061 ccgaggcggg caccccactg gagcgggtga cggcgatggc ggcgcgggtc gcgagatcac
    18121 tggtcgaggc gccggacttc ctgcgtctgg gcctgatgct cgccttggag cgacgccccg
    18181 ccgagccccg gggccgggcg gtgttcctcc aggtgcgcga cctctcccgg cagcgggtcg
    18241 cggacatgat ccgcgccctg ttcccgaccc tcgacgagga cgtcgtccac accctgacga
    18301 cctacgccgt ggccggagcc gacggactgt tcgtgcaccg cgagatcggc ggcgactcgg
    18361 tcgacctggt ggcgatgttc gagctgcacg cacggctcgt ctacgaggcc gcgcgcggga
    18421 tgacaccgac ccattgcccc aaggaggcca aggcatgacc accgcacccc gccgtatcga
    18481 cgtccaccag cacctcatcc cctccctcta ccgcgacgcc ctcgccgcgt ccggcatcac
    18541 ggaggcgggc ggccgtgccc tgcccgactg gagtcccgag gcggccctgg agtcgatgga
    18601 cctgctcggc accgagactg cgatcctctc ggtctccacc cccggcaccg gcttcctcac
    18661 cgaccccgat gaggccgccg gcctggcccg gcgcctcaac gaccactgcg ccgagctcac
    18721 cgcccaacac cccgcccgct tcggctggtt cgccacgctg cccatgcccg atgtcgccgc
    18781 gtcggcgcgg gaggccgggc gtgcgctggc cgagctgggg gccgacgggg tgacgctgct
    18841 ggccaacaac cggggcgcct acctcggcgc cgagggccag gacgccctgt gggaggtcct
    18901 cgacgagcac ggtgccgtcg tcttcgtgca tccggccgaa ctccccgcgc ccgccgtcga
    18961 cggcatcctg ccgttcgccg ccgacttcct cctcgacacc acccgcgccg cgtatctcct
    19021 cgtacgcaac ggcgtcccgc gccgctaccc caacatccgg ttcatcctca gccacggcgg
    19081 cggcttcgtc ccgtacgcct cccatcgcat ggccgtcgcc atcgccggtg acatcggacg
    19141 cggcccccat gacgtcctgg acgacttccg gggtttccac ttcgacaccg cgctgtcctc
    19201 cagccccgct gccctgccca cgctgctcgc cttcgcccgt cccgggcacg tcctgttcgg
    19261 cagcgactgg ccgttcgcgc cggccgcggc gggacagtac ttcgcggccg ggctcgacag
    19321 cggtgtcgac cccgacaccc tcgcgacgat caaccgcacg gccgccgagg cgctcttccc
    19381 gcgcctggcc gggagcaggc ccgcgccgcc ggagccgcgt cccctcgcgg tgcgtctgcg
    19441 gcggtccgtg cggcgcgccg gggcccgtgc cgtgttcaag ctcatccagc ccgggagcga
    19501 ctgaggccgg gaccggctga ggccgggacc ggctgagggc cgtgggcggc ggcctattcg
    19561 ctcagtgccg cccagaccgt cttgccgtgc cgggcgtggc gggtgcccca ctgcccggcg
    19621 agctgggcga ccaggagcag accgcggcca ccctcgtcga agacccgggc ccggcgcaga
    19681 tgcggggtgg tgccgcccgc gtcggagacc tcgcacagca gggcgcggtc atggatgaga
    19741 cgcagactga tcggggaacg cccatagcgg atggcgttgg tgacgagttc gctgaccacc
    19801 agctcggcga cgaaggcgag ttcctccagg ccccaggcgg ccagttgccg ggagacgtcc
    19861 gcacgggcac gcgccacgac cgccgggtcg gcgtccaact cccaggtgac gacccggtcg
    19921 gcgcccagcg cacgggtacg ggcgaggagc agggcgatgt cgtcgtccgg ccgggacgga
    19981 agcagggcct ccagcacggt gtcgcaggcg gtctccaggg acggggccgg gcgggcgagg
    20041 atccggcaca gggtggtgag gccgacttcg atgtcggggg tgtctggagc gggggtgtcg
    20101 ggagccgggg tgtcgggagc cggggacacg tcgtcaacgc cctccgccgc cctcgcctcg
    20161 atcaggccgt cggtgcacag ggcgatcagg ctgccctcgg gcaggtcgac ctccagcgcc
    20221 tcgaacggca gcccgccgat gcccagcgga ggaccgggcg gcagttccag gacgtccgcc
    20281 gtgccgtccc ggaccaccac ggcaggcggc acatgccccg cgcgggccag ggtgcagcgg
    20341 cgcgcgacgg ggtcgtagac ggcgtagagg caggtggcac cgttgtcccg gcccacgtcg
    20401 gcctcgggtt cggcgtccgg gtccgtgccc gcctcggtgg ccaggcgcag gacgacatcg
    20461 tccaggtggg tgaggagctc gtccggcggc agatcgatgt cggccagggt gcgtacggcg
    20521 gtccgcagcc ggcccatggt ggcggcggcg cggatgccgt gaccgacgac atcgcccacc
    20581 accaacgcca cccgcgcgcc ggacagcggg atgacgtcgt accagtcacc gcccaccccg
    20641 gtctcggagc cggccgggag atagcggtag gcgacgtcca cggccgactg ccgcggtgcc
    20701 gcccggggga gcaggctgcg ctggagggtg agggcggtgg cacgcgcgtg tgtgtagcgg
    20761 cgggcgttgt cgacggctac ggcggccctg gcgacgatct cctgggcgag cagcagatcc
    20821 tcgtcgtcgt agtgccgggc ggggccgtag cggtggaact gggcgacgcc cagcgtggtg
    20881 tcccgggcgc gcagcggcac gaccagggtg gaaccgtcgc tcggggcgcc ccacgccccg
    20941 ccctgccgct gccggctggg ccgtccgctg ctcagtgcct gcgcgcacgg cgatccgtcc
    21001 gggcaggtgt gcagctgcct cggtgcgatc gccggttccg ggccggcccc gcccgtcggc
    21061 ccctcggcca tccggcgcag catcagcggg ccctcccccg ccgcgtcccg tccgcgcagc
    21121 acggtgtcga gcaggtcgac ggtgaccagg tcggcgaact gctggacggc gaagtccgcc
    21181 agttcctggg tggtgcgggc gatgtcgagg gtggtgccga tgcacatact ggcctcgttc
    21241 accatggccg accgccaccg cagccgccgg tcccgttcct cctggaacgc gacgacaccc
    21301 tgctccgcca cccggtccac ataggtggtc gccagcgcgg tgagctgccg cgccgccaca
    21361 ctgacctgct cggcgtcgtc gctgagccgg ggcagttccg cgaacagccg gtcgctgacg
    21421 atctcctgcg ccagccggaa ggcacgcagc atggtgctga gaggtgtgcc gtgccgggcc
    21481 agcacccgcg cacgctccac atcggcgggc ggcagttcga tcaggctcgg ctcgatcgcg
    21541 tgttcgattc cgaacagggc ggcggcggtg tgctcgacga cgttctcggc ggccgtcctg
    21601 gcgacgtccg ggttctccca cagcgcgggg agttcgcgcc gcaggcgttg ttccacgtcg
    21661 gccgtgagct catcggtccg cgagccgagc tcatgcgccg cacgcgagag aagaccgccg
    21721 ggcgtgggct ccacacagac gacgttacgc cgctctcatg gatgcctcag accggacggg
    21781 ccgcctcctg tccaccgtcg tacgggccgc acccgtcacc cgcccccgcg cagcacccga
    21841 gacagtccga gcgccgccgt ccgtacggcg ggtgccagct gggcggggct gaagcgggcg
    21901 cgcggcacgg ccaccgagag ggcggcgacc gtggtgccgc ctgcgaagac gggcgccgcg
    21961 atgcagctca cgccgagggc ggcctcctgc tcctcgtagg cgaggccgga gacccgggtc
    22021 ttctccaggg ccatgcgcag ccggttcggg tcggtgatgg agtgcggggt gaggctcggc
    22081 agcggccggg acagcacctc ctcggtgagc tcggcgccgg agaaggcgag cagggccttg
    22141 ccgaccccgg tgcaggtcag cgggaggctg ccgccgatac gggagggcag ctggagtgcc
    22201 tcgtggccgt ggatgcgctc caggtagacc acgtccatgc cctcgcggat gccgaggtgg
    22261 acggtctcgc gggtggcctc gaacaggtcc tggaggaacg gcagggccgc ctcgcgcaga
    22321 tcgagccggt gcggcaccag cgagcccagc tcgaacagct tcgcgccgag ccggtaccgg
    22381 gtgcccgagc gctccagcca gcccagccgc accaggtccg ccgccagccg gtgcaccgtg
    22441 gccttgggca gcccggtgcg ctcggaaagt tccgacagac ggtacggtcc gccgctcggg
    22501 ctgaagctct ccaggatggt cgcggccttg tccagcatgt tgctgccgcc cacgttgttc
    22561 cgcgtcacgg aacaaagttt ggcgctcttg ctcagggcct gtctatatcg gaagcggcag
    22621 ccgcatcgaa ggcggcagcc acatcgaagg cagccatcac atcgaaggcg gcaaccgccc
    22681 gttcccctgc cctggaggta tcccgtgccg accgcacccg acggtgtccg tccggacgcc
    22741 gccccaccgg ccgtcgtcca ggccgccgac ctgctggcgg aggccgcccg gaccggggcc
    22801 gcgtgtcctc cggtgcgtga gctgttcgac ggcggcggcg atctggcgac cgcgtacgcc
    22861 gtgcaacagc tgggcgtccg gcgtggcctg gacgccggcc gccggatcgt gggccgcaag
    22921 atcggtctga cctcggtggc cgtgcagcgc caactcggcg tggaccggcc ggacttcgga
    22981 gcgctgttcg cggacatggc cgtaccggac ggcggtgagg tggccgccgg gcggctgctc
    23041 cagcccaagg tggaggccga ggtggcgctc gtcctcgggc gggacctgcc ggagcgggcg
    23101 tgcacggtcg tggatgtgct gcgggcggtg gacttcgcgc tgcccgcgct ggagatcgtg
    23161 gacagccgta tcgccggctg ggacatctcc ctggtcgaca cggtcgcgga caacgcctcc
    23221 tgcggcctgt acgtcctggg cgcgaccccc gtaccgctca ccgccgtcga tctgcggacg
    23281 gtgacgatga ccatgacccg gggcggcgac tccgtctccg agggcaccgg cgccgactgt
    23341 ctcggcagcc cgctcaacgc ggccgtgtgg ctggcctcca cgctcgccga gcggggcgat
    23401 ccgctgcggg ccggcgacct ggtgctgacc ggcgcgctcg gccctatggt gcccgccgtg
    23461 ccgggggatg tgttcgaggc acatatctcg gggctgggct ctgtgcgggt cggcttcgcc
    23521 aaggaatccg ccgaggaagg gggcgagctg tgagcaccaa ggtcgcgatc ataggttccg
    23581 gcaacatagg gaccgacctc atgatcaagg tcctgcgcct gtcggagtcg ctggagatcg
    23641 ccgcgctggc cggcatcgac ccggcctcgg acggcctggc ccgcgcccgg cgcctcaagg
    23701 tcgccacgac ccacgagggc gtcgaagggc tcgtcgcgct ggacgagttc gccgatgtgg
    23761 agatcgtctt cgacgcgacc tcggccggtg cccaccgcca ccacgacgcg gtgctgcgcc
    23821 cgctgggccg caccctcgtc gacctcaccc cggccgccct cggcccgtac gtcgtcccgc
    23881 cggtcaacgg cgacgcccat ctcgacgccc cgaacgtcaa catggtcacc tgcggcggcc
    23941 aggccaccat cccgatcgtc gccgccgtgg gcgcggtcac cccggtccac tacggcgaga
    24001 tcgtcgcgtc cctcgcctcc cgctccgccg gaccgggcac ccgcgccaac atcgacgagt
    24061 tcaccgagac cacctcctcc gccatcgagc aggtcggcgg cgcagcgcgc ggcaaggcga
    24121 tcatcgtcct caacccggcc gaacccccgc tgatcatgcg ggacaccgtg cactgcctgg
    24181 tctccgactg cgccaccgag gcggtcacgg cgtcggtcga ggagatggtc gggcgggtcc
    24241 aggcgtacgt ccccggctac cggctcaagc agaaggtgca gtacgagcgc gtcgccgccg
    24301 acgacccgct gagcaccctc gccccgagcg gcggcgatct cctgaaggtg tccgtcttcc
    24361 tggaggtcga gggtgccgcg cactacctcc cgtcctacgc cgggaacctc gacatcatga
    24421 cctcggccgc cctgcgcacc gcggaacgca tggccgcccg ccccatcgct ccgaaggtgg
    24481 cctcccgatg acccggctct acgtccagga cgtgaccctg cgggacggca tgcacgccgt
    24541 ccgccaccgc tacaccaccg gccaggcccg cgccatcgcc tccgcgctcg acgccgccgg
    24601 agtggccgcg atcgagatcg cccacggcga cggcctggcc ggctccagca tcaactacgg
    24661 catcggcgcc cacaccgact gggagtggat cgaggcggtg gtggacgtcg cgcaccaggc
    24721 gatccccaca accctgctcc tccccggcat cggcaccctc cacgacctgc ggcaggcgca
    24781 caccctgggc atccgctcgg tgcgcgtcgc cacacactgc accgaggccg acatagcggc
    24841 ccagcacatg gccgccgcgc gggagctggg catggacgtc gccgggttcc tgatgatgtc
    24901 ccacatggcc gagcccgccg aactcgcccg ccaggccaag ctgatggagt cctacggcgc
    24961 ccactgcgtc tacgtcaccg actccggcgg ccgtctcacc atggacggcg tccgcgaccg
    25021 cttccgcgcc taccgcgacg tcctgtctcc ggagacggag ctgggcatcc acgcccatca
    25081 caacctcgcc ctgggcgtgg ccaacacggt cgtcgccgtg gagagcggcg cggttcgcgt
    25141 cgacgcctcc ctggccgggc agggcgcggg ggcgggcaac tgtcccctgg aagccttcat
    25201 agcggtcgcc gacctcatgg gctgggacca catgtgtgaa ctgttccccc tgatggacgc
    25261 cgccgacgat ctcgtacggc cgctccagga ccgcgaggtg cgggtggacc gcgagaccct
    25321 gagcctcggc tacgcgggcg tgtactccag cttcctgcgc cacgcggaga ccgccgccga
    25381 acggtacggc ctggacaccc gcggcatcct cgtcgaggtg ggacggcggc gcatggtcgg
    25441 cgggcaggag gacatgatca ccgacatcgc gctggacctg gtggcccgtg cggggaccgt
    25501 gtcctgacgc cgtgtcatga cggcgcgccc tgacgccggt ccccgcgcgg gcaccggcgt
    25561 cacgccttcg acagggtgac gttcttcttc agtacggcgt ggaagtgcgg cagcggcagg
    25621 ccgccgagga cgtccatggg ccggagttcg acgatggtgg cctcgacgtc ggccttgccg
    25681 tgcttgagcg tggacgggga gggcttgctc ttgttctgcc agcggtgttc cttgccgtcg
    25741 cactcggcga cggtgccgcc gatggcgtac cggttggtgg aggccttctg gcccacggag
    25801 gcgctcacga acgtgggccc cgcgctgtcg acgcacttgt aggttccgga gacggtgacg
    25861 gtgccgtccg ctgccatgac ggccgcggtg tcgacggtca ccgtctcctc gggctcggcc
    25921 ttggtgtcgg agtcggcggg ggccgagggc gcggcgacca gcaggagcag ggcggcgccg
    25981 acggcggtgg cgagagcggg acgcaggtgc atgggatgac ctcccgggtg ggcggagtgg
    26041 ggcctcccac tggtacccgg cgggtgcgcc caggagcgtg atcgtcaccc cttcggtggc
    26101 gagtccgccc cgaccttcgt ggatcggtca gagagttgtc cgcgtgttgt cacggttcac
    26161 ggcgggccgt tccgatgagt tcgtggcggg agcatggtct acccatatgg acgacccgta
    26221 cggctcgtcc gccctatgtg gaggtgcgcc atgtgttcct accagccttc gtgcccttcc
    26281 tcctcggacg accgcagcgc acatgtggtg gccgcacacc ccgagcaggg ctggagcctg
    26341 ctgtgcagtg gcgcgatcgt gttcgacgac agcggcgagc tgctgcccga cggccgtgtg
    26401 gtggccccgc accgggtgcc ggccgcgcgc ctcgcgatgg cggcgtgacc gggatctacg
    26461 gcagcaccgc gaacccgtcg agctccacca tcgccgcctc gtcccagagg cgcacggccc
    26521 cgacgaccgc catcgccgga taggtacggc ccgccaactt ccgccagatg gcgccgagtt
    26581 cggccgcctg ggcacgatac gccgcgacgt cggtcgcgta gacggtgacc cgggcgagat
    26641 cggccggtgt gccgccggcc gccgccagcg cggtcagcag actggtgagc gcccgctcga
    26701 actgctccgg cagtgactcc ccgaccacct tgccgtcgga gtccagcgcg gtctgcccgg
    26761 cgaggaacac gacgcgcgag ccggtggcga cgaccgcgtg ggagaagccg gtgggcgggg
    26821 agaggtcggg tgggttgacg cgctcggtgc tcactggccg gcctccatgg tggcgtacaa
    26881 ctccttggcg atgatgccgc gttgcacctc gcttgcgccc tcgtagatac gtggcgcgcg
    26941 cacctcgcgg tagaggtgtt cgagcagatg gccgtggcgc agggcgcggg cgccgtgcag
    27001 ttggacggcc ttgtcgacga cgtactgcgc ggtctcggtg gcgaggagct tcgccatcgc
    27061 ggcacgttgg gggacgtccc gggatccttc gtcgtacgcc gcggccgccg cgtacaccat
    27121 gagccgggcc gcctccgtgc gcagggccat ctcggcgacc tggtgggcga ccgtctgaag
    27181 gtccttcaac ttgccgctga aggcgtcccg ttcggcggtg tgggcgaggg tcgcgtccag
    27241 ggcggcctgt gccatgccga cggcgaaggc gccgacgctg ggccggaaga ggttgagggt
    27301 gcccatggcg acccggaagc cgcggtcggg ttcgccgagc atgtcgtcgg cggtgacggg
    27361 gacggcgtcg aaggtgaggg cgccgatggg gtgcggggac agcatgtcga ggcccgttcc
    27421 ggtgagtccg ggccggtcgg cggggaccag gaacgcggtg acgccgcggg cgccggcgtc
    27481 gggggtggtg cgggcgaaga cggtgtagaa gtcggcctcg ggagcgttgg agatccagca
    27541 cttctcgccg gtgaggcgcc agcggacggg gcccccgtcc cccgcaggct ccggctccgc
    27601 gcgcagctcc agtgccgccg cgtccgaccc ggcccccggc tcgctcagcg cgaacgccgc
    27661 caccgtgctg ccctcggcca ccccgggcag ccagcgttcc cgctgggccg gggtgccgta
    27721 cgcgtggacg gggtgtgcgc ccaggccctg cagggcgagg gcggtctcgg cctcggtgca
    27781 ggcgtgggcg agggactccc gcatcaggca caggtcgacc gctccggagg tgaacagccg
    27841 ctccagcagg cccagtcggc cgagttcggt gacgagcggg cggttgacat gcccgggttc
    27901 gcccttctcc gcgagtgggc gcagccgttc ggcggcgagg gtgcgcagct cggcacaccg
    27961 ggcggtttgc gccggatcga gtgagaatgc gggcattgcc gacctccctg ggggccgagg
    28021 acgatccctc tcgaagatat cgcgctccat tgactgtcgt caccaacacg atacgctccc
    28081 tgtgcgagcc caccacgacg cccacaagca cgacgcccat aaggcagcca caaggcaagg
    28141 gggcgaaccg ccatggccgg tctgcaccgc tccgcccacg tcgacacctt cgcccgcgag
    28201 catctgccgc cgcccgaaga gtggcccgag ctccgcttcg acctgccggg gctgcactac
    28261 cccgatcggc tcaacgccgc cgccgaactg ctggacggcc ccgacgacga ccggcccgtc
    28321 ttccacaccc cgtccggccc cacatggacg tacggcacac tgcgtgccca cgtcgaccgg
    28381 ctcgcacatg tgctgaccac ccacctcggc gtcgtcccgg gcaatcgggt gctgctgcgt
    28441 ggcccgacca caccatggct ggcggcctgc tggctggcgg tgctgaaagc gggcgcggtc
    28501 gccgtcaccg tgctggccca gcagcggccg cacgagctgc ggaccatgtg cgagatcgcc
    28561 caggttcggc acgcgctgtg cgacatccgc gccgtcgacg acctcgccaa ggccgagatc
    28621 cccggcctgc gcctcgccac gtacggcggt gacgcaccgg acgacctgct gcgcctgccg
    28681 gcccccgaca ccccgtaccc cgccgcggac acggcgtccg acgacgtggc cctcatcgcc
    28741 ttcacctcgg ggaccaccgg tcgcccgaag ggctgtatgc acttccaccg ggatgtgctc
    28801 gcgatagcgg acaccttctc ggaacatgtg ctgcaaccac atatgggcga tgtcttcgcc
    28861 ggcagtcccc cgctcggctt caccttcggc ctcggcggac tcgtgatctt cccgatgcga
    28921 gccggcgcca gctccctcct cctggaacag gcgggtccca agcagctgtt gcccgcgatc
    28981 gccgagcacc gggtgtccgt gctgttcacg gccccgacgg cataccgcgc gatgctcgac
    29041 gagctcgact cgggcgacat ctcctccctg cgccgctgcg tctccgcggg cgagaacctt
    29101 cccgcggcca cctggcgggc ctggcacgag cggaccgggc tgcgcgtcat caacggcatc
    29161 ggcgccaccg aactgctgca catcttcatc tcggcggccg acgaacacat caggccgggg
    29221 acgaccgggg tgccggttcc gggctggcac gcgcgcgtgg tcgacgccga gggccacgac
    29281 ctgcccgacg gggagcccgg actgctcgcc gtccgcgggc ccgtcggctg ccgctatctc
    29341 accgaccccc ggcaacgcga gtacgtgcgc cacggctgga acatcaccgg cgacacctac
    29401 gtccgggaga gtgacggcta cttccgctat gtcgcccgcg cggacgacat gatcatctcg
    29461 gccggttaca acatcgcggg ccccgaggtc gaggaagcgc tgctgcgtca tccggatgtg
    29521 ctggagaccg cggtggtggg gcggcccgac gaggcgcgcg gccaggtcgt ggtggcatac
    29581 gccgtgctca gggagggtgc gcgacgggac gcggaggtgc tgcggacgtt cgtcaaggcg
    29641 gagctggcgc cgtacaagtg cccgcgtgag ttcgtcttcc tggacgcgct gccgcgcacc
    29701 gcgaccggca agctccagcg gttccggctg cgcgacggcg gtcgtccaca gggcgcccag
    29761 cagtgatccg tacgaactaa gatgatcaac gtgtccgacc agcatgcacc acggtctctc
    29821 atcgtcacgc tctacggcgc gtacggccgc catatgcccg gcccggtgcc ggtcgccgag
    29881 ctgatcagac tgctggccgc ggtcggcgtg gacgccccct ccgtgcggtc gtcggtgtcc
    29941 cggctgaagc ggcgcgggct gctgctgccg gcccgtacgg cgcagggcgc ggccggctat
    30001 gaactgtcgc cggacgcccg ccagttgctc gacgacggcg accagcgcat ctacgccacc
    30061 gtgccgcctg acgacgaggg gtgggtgctc gcggtgttct cggtgccgga gtcggagcgg
    30121 cagaagcgcc atgtgctgcg ctcccggctg gccgggctcg gcttcggcac ggcggccccg
    30181 ggcgtgtgga tcgcgcccgc gcggctctac gaggaggcca ggcacaccct cgcgcggctg
    30241 cgcctggcgg agtacgtcga cttcttccgc ggcgagcacc tgggtttcac accgaccgtg
    30301 gaggccgtcg cccgctggtg ggacctggcg gcgatcgcca aggagcacga cgccttcctc
    30361 gaccgccacg cgcgcgtgct gcacgaatgg gagcgccggg ccgacacccc gcccgaggag
    30421 gcctaccgcg actacctcct cgccctggac tcctggcgcc acctccccta caccgacccc
    30481 ggcctcccgt cccggctgct gcccgaggac tggcccggcg cacgctcggc cgccgtcttc
    30541 cgaggactgc acgagcgcct gcgggacgcg ggagcgacat acgcgggcct atgacatcgg
    30601 gcacagtttg cgcccctaac ggaaccctca ggttcctctg cgcctcttct caagtttctt
    30661 acctagaggt tgtcccgtaa ccggtggggc ggttggtgcg ttggttgggc atgggtgggg
    30721 tga
//
