LOCUS NZ_BNBM01000001 11329 bp DNA linear CON 02-SEP-2024 DEFINITION Streptomyces lanatus strain JCM 4588 sequence01, whole genome shotgun sequence. ACCESSION NZ_BNBM01000001 VERSION NZ_BNBM01000001.1 KEYWORDS WGS; RefSeq; STANDARD_DRAFT. SOURCE Streptomyces lanatus ORGANISM Streptomyces lanatus Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Wu,L. and Ma,J. TITLE The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing project: providing services to taxonomists for standard genome sequencing and annotation JOURNAL Int J Syst Evol Microbiol 69 (4), 895-898 (2019) PUBMED 30832757 REFERENCE 2 (bases 1 to 1203604) AUTHORS Sun,Q. and Ohkuma,M. TITLE Direct Submission JOURNAL Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL :http://www.wdcm.org/ COMMENT ##Genome-Assembly-Data-START## Assembly Method :: gcType assembly pipeline Genome Coverage :: 61X Sequencing Technology :: Illumina HiSeq X Ten ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_014655715.1-RS_2024_09_02 Annotation Date :: 09/02/2024 05:46:35 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.8 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 9,254 CDSs (total) :: 9,172 Genes (coding) :: 8,973 CDSs (with protein) :: 8,973 Genes (RNA) :: 82 rRNAs :: 2, 2, 2 (5S, 16S, 23S) complete rRNAs :: 2 (5S) partial rRNAs :: 2, 2 (16S, 23S) tRNAs :: 73 ncRNAs :: 3 Pseudo Genes (total) :: 199 CDSs (without protein) :: 199 Pseudo Genes (ambiguous residues) :: 0 of 199 Pseudo Genes (frameshifted) :: 83 of 199 Pseudo Genes (incomplete) :: 153 of 199 Pseudo Genes (internal stop) :: 16 of 199 Pseudo Genes (multiple problems) :: 50 of 199 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 03:57:39 NOTE :: This is a single region extracted from a larger record! Orig. start :: 1090677 Orig. end :: 1102006 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to BNBM01000001.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..11329 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="6" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..11329 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..11329 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:6329](+)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core 5001..6329 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" misc_feature 1082..1095 /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 18.58" /tool="antismash" misc_feature complement(1396..1409) /note="TFBS match to PsrA, Oleic acid responsive regulator, confidence: weak, score: 19.11" /tool="antismash" misc_feature 1399..1414 /note="TFBS match to RutR, Regulator of the pyrimidine and purine metabolism, confidence: weak, score: 20.03" /tool="antismash" misc_feature complement(1406..1419) /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 13.08" /tool="antismash" gene 1429..2289 /locus_tag="IE325_RS04820" /old_locus_tag="GCM10018780_09750" CDS 1429..2289 /GO_function="GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Evidence IEA]" /GO_process="GO:0005975 - carbohydrate metabolic process [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1235: polysaccharide deacetylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_011030618.1" /locus_tag="IE325_RS04820" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09750" /product="polysaccharide deacetylase family protein" /protein_id="WP_190068373.1" /transl_table=11 /translation="MITLVRRVTALCALGAALSVLASCAGPEEMTRAPLPAPSATASVS PSLRAPTLAPGPGGTAPVFEHGPRSGDKAVALTFDADMTADQGPRAAQGERFDNPGLIV ALRELKVPATVFMTGRWAEEYPEQARSIGRDPLFEVANHSYSHHSFTDDCYGLPTIAEE RMRADVERAYAVFRKVGVRDAMPYFRFPGGCYDRRALRALTPVGVTAVQWDVVSGDAFA TDAGAVARGVLDEVRPGSVVVLHCTRSAAPTTERVVRGVVPELRREGFRFVKVSELIRA SGTRR" gene 2308..2517 /locus_tag="IE325_RS04825" /old_locus_tag="GCM10018780_09760" CDS 2308..2517 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007503632.1" /locus_tag="IE325_RS04825" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09760" /product="hypothetical protein" /protein_id="WP_190068374.1" /transl_table=11 /translation="MSEDYCTIADAVKPPWGSPHALKAVGEDGPPYAECVLCREPTEYP ESYKGITLCPVCEWQEAQRTACSG" gene complement(2509..3180) /locus_tag="IE325_RS04830" /old_locus_tag="GCM10018780_09770" CDS complement(2509..3180) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997023.1" /locus_tag="IE325_RS04830" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09770" /product="ABC transporter" /protein_id="WP_190068375.1" /transl_table=11 /translation="MTALLRYQAALLVRSQRWLPPFLLYVVFLGIGVQGGQPILDSLGY TAAALLPVTAWLVRICVTNEPPAARSCVSAAVGPGRAHLAALLVALGTAVALGVVATVV VTLISNPASADLQTRVPRLPAGAAGLLAVLACALLGTAVGALTTWPLLRSTGRAIPAML LAALLSVVVTGSPAQAAVSGLVTGSNSGRVPMPVLPLAAAALLTAAAIAVACALTSRRS P" gene complement(3177..4052) /locus_tag="IE325_RS04835" /old_locus_tag="GCM10018780_09780" CDS complement(3177..4052) /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1000: ABC transporter ATP-binding protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997024.1" /locus_tag="IE325_RS04835" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09780" /product="ATP-binding cassette domain-containing protein" /protein_id="WP_190068376.1" /transl_table=11 /translation="MQRDLRLDNVGRRYGLRGPWVLRGIHLTVPPGTLIRIEGPNGTGK STLLRLLARIDAPSEGRVSGAPRTAYVPERFPTALPFTALGYLTHLGTVHGLSRPAATR AALEWLDRFGAAPYARTPMAQLSKGSSQKVAVVQALLAEPELLVLDEAWTGLDSDARAE LERAVAERTAGGTAVVFVDHDPRRLAGVPDATYTVRDSGLDLRTEQPPEEAAGPRVTVV AQGPSGGQLPGDAQRAVVAAEEPAPGTHRLTVPASHSDILLRALLTARPPWHVVSVRQE PAGPDTESRR" misc_feature complement(3987..3989) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene 4051..4806 /locus_tag="IE325_RS04840" /old_locus_tag="GCM10018780_09790" CDS 4051..4806 /EC_number="3.1.1.29" /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003997025.1" /locus_tag="IE325_RS04840" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09790" /product="aminoacyl-tRNA hydrolase" /protein_id="WP_373315086.1" /transl_table=11 /translation="MGASSPTARVGRLDRVNSDPSIDSPFRSEPSTRDEAPQFVLPLVV RIERSAPPARTDALETSARAVLTILSDERSLGDGEWAEAMRDWQDARIRKVVRRARGAE WRRAEELPGITVTGKSAEVRVFPPVPLDGWPKELAKLQVSGTDLDDPEPPVDADPSGPV LWLNPELDMSAGKTMAQTGHAAQLAWWELSDEERAAWRDAGFPLAVRTAQPGPWRELTG GGLPLVRDAGFTEIAPGSCTVVADHPALR" gene 5001..6329 /locus_tag="IE325_RS04845" /old_locus_tag="GCM10018780_09800" CDS 5001..6329 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: DUF692" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020122140.1" /locus_tag="IE325_RS04845" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09800" /product="DUF692 domain-containing protein" /protein_id="WP_190068378.1" /sec_met_domain="DUF692 (E-value: 1.2e-98, bitscore: 325.6, seeds: 7, tool: rule-based-clusters)" /transl_table=11 /translation="MERLGTGIGWRPEIADAVERMPGIDWVETVAENVCPGHLPESLVR LRERGVTVIPHGVSLGLGGADRPDADRLAALAERVAALGAPLVTEHIAFVRAGGPLTAS PRLEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLAVENIAALIAWPGEEMSEGQFLY ELADRTGVKLLIDVANLYTNHVNRGEDPAKALAELPLEAIAYVHVAGGFERDGVWHDSH AHPVPQPVLDILTDLASRVSPPGVLLERDENFPEPAELEGELGAIRRALEKGAAERRAS ASGNRATSADRLPSPHESSAPDLAPARQRLALAQAALLSALVAGTPVPEGFDRVRVGVQ ARALAGKRADVVAKVAPELPVILGGGYRRAFLAYANGQPMTDGYRRDALDFAGYLLAEG RCEDVGTRAELREWWLERSGPKPRSRRPGVRLARATRRVLLRR" misc_feature complement(6548..6564) /note="TFBS match to HexR, Glucose-responsive regulator, confidence: weak, score: 17.02" /tool="antismash" misc_feature 6594..6610 /note="TFBS match to GnfM, Regulator of nitrogen-fixation genes, confidence: weak, score: 20.35" /tool="antismash" gene 6613..7392 /locus_tag="IE325_RS04850" /old_locus_tag="GCM10018780_09810" CDS 6613..7392 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020133764.1" /locus_tag="IE325_RS04850" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09810" /product="DUF4142 domain-containing protein" /protein_id="WP_190068379.1" /transl_table=11 /translation="MRPRPRPPIKGRGIFSGTGLIITGLAATLLAMIFPIWSYADRSGT GLDVLNAETVSTGYGPLSALDRDFLTKVRLAGLWELPAGEQARTKGTTPAVRTAGEHLI EGHAFLDERVRDVAAKLSLALPNEATEQQRQWLATLDSAQGVEYDRQFANILRLAHGKV FSVVAQVRASTRNSLVRKLADDANTTVLDHITVLEATGYVDFDALARDMVADSTPPLTA PPAPPGPTADPAPAVPMTPPPSPTYTLPPAATSPRPS" misc_feature complement(7412..7426) /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 19.38" /tool="antismash" gene 7496..8287 /locus_tag="IE325_RS04855" /old_locus_tag="GCM10018780_09820" CDS 7496..8287 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019073953.1" /locus_tag="IE325_RS04855" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09820" /product="TIGR04222 domain-containing membrane protein" /protein_id="WP_190068380.1" /transl_table=11 /translation="MFWVLLLLLAWAVAGTACTRLCLAAVQTAAMERKEATTARDHDLT LYEAAFLSGGPRRVADLTLVSMARQQRLLLAHTGWATVVDPRGRDEMERSVIGAIGPEG QSRIEPVRDAAAAAEAVGSLADRLVSAGLAVPDAARDGIGSAIRQVRLAAAVVLALGAV ALLAPAQSDMPAHLVALWFALPFVLTLSCLAIARVEIHPYAQWASPAGQRLLSGLIRRS GGGDDRTYLTFVAVRGVRAVGEPELRAAFAHRAHGASHWPD" gene 8429..10075 /locus_tag="IE325_RS04860" /old_locus_tag="GCM10018780_09830" CDS 8429..10075 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (109-483). E-value: 1.5e-21. Score: 69.0. Matches aSDomain: nrpspksdomains_IE325_RS04860_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019981759.1" /locus_tag="IE325_RS04860" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09830" /product="alpha/beta hydrolase" /protein_id="WP_190068381.1" /sec_met_domain="PF00561 (E-value: 7.5e-25, bitscore: 84.0, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MRAAALYSAAGAMLLSALSLAPAGHAGAAPAADEQRGTAVAAARA RAAGIDFDRCPKDQGLPGHVRCGTVSVPLDYARPDGKQIRLLVSRAPATHKDPHNSKHR VPGKGPLVYNPGGPGASGLQFPLIGVLPAWKRLAAAYDLVGYAPRGVGPSARLSCQDPK HYLKGPAQAPTYPSESYKKERVARAKAYARGCAERAGSALQYYNSLNNARDLDVLRAAL GQSKLTFMGASYGTYFGALYAHLFPSHVRRMVFDSAVNPDPKQIWYHNNLAQSAAFEGR WADFREWVAEHDDVYGLGITAAEVLDNYDEVRTRLASEPAGGKIGPGQLQEAFLQAGYY DDYWPSRAHALSAYLKGDTKPLVELASPATEAAAEEENTNAVYTAVECNDAPWPTDWAV WDRDNTRLARVAPFETWDNAWMNLPCAFWQAPRQQPLDVRTGPGELPPTLILAAERDAA TPYDGALEMHRRLAGSVLVTERDAGTHGIAYGPNKCVNGYVDAYLLEGRLPTRHASCEG HPEPKPQRAGERKTKKSAAQHKDRHETAARP" aSDomain 8756..9877 /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_IE325_RS04860_Abhydrolase_1.1" /evalue="1.50E-21" /label="IE325_RS04860_Abhydrolase_1.1" /locus_tag="IE325_RS04860" /protein_end="483" /protein_start="109" /score="69.0" /tool="antismash" /translation="PLVYNPGGPGASGLQFPLIGVLPAWKRLAAAYDLVGYAPRGVGPS ARLSCQDPKHYLKGPAQAPTYPSESYKKERVARAKAYARGCAERAGSALQYYNSLNNAR DLDVLRAALGQSKLTFMGASYGTYFGALYAHLFPSHVRRMVFDSAVNPDPKQIWYHNNL AQSAAFEGRWADFREWVAEHDDVYGLGITAAEVLDNYDEVRTRLASEPAGGKIGPGQLQ EAFLQAGYYDDYWPSRAHALSAYLKGDTKPLVELASPATEAAAEEENTNAVYTAVECND APWPTDWAVWDRDNTRLARVAPFETWDNAWMNLPCAFWQAPRQQPLDVRTGPGELPPTL ILAAERDAATPYDGALEMHRRLAGSVLVTERDAG" gene complement(10143..10874) /gene="hemQ" /locus_tag="IE325_RS04865" /old_locus_tag="GCM10018780_09840" CDS complement(10143..10874) /EC_number="1.3.98.5" /codon_start=1 /gene="hemQ" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018564417.1" /locus_tag="IE325_RS04865" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="GCM10018780_09840" /product="hydrogen peroxide-dependent heme synthase" /protein_id="WP_190068382.1" /transl_table=11 /translation="MSDDAPTTEPGRIPNKGKLAKDLNEVIRYTLWSVFKLKDVLPEDR AGYADEVQELFDQLAAKDVTIRGTYDVSGLRADADLMIWWHAETADQLQEAYNLFRRTK LGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRR MLADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARMHVR EEVPFYTGRRKSVAELVAGLA" ORIGIN 1 gctcaaggcg gtccgctccg acgcggacac ggtcggtctg gtgcgtgagc gtgtgatgcg 61 ggaggcgcgg gcgctggccc ggctcagcca cccccatgtg gtgacggtcc atcagatcgt 121 ggacgcggag ccgcacccgt ggatcgtgat ggagctggtc ccgggcatct cgctccaaca 181 gcacctggac aacggcccgt tgacgccgcc cgcggcggcc cggctgggcc gtcaggtgct 241 cgccgcgctg cgtgccgcgc acgcggcggg catccagcac cgggacgtca agcccgccaa 301 catcctgctg cgccccgacg gcagcgccgt actcaccgac ttcggcatcg ccgccctcca 361 gggcacgacg ggtctgacgg ccacgggcga gttcgtcggg tcgcccgagt acatggcccc 421 ggagcggatc aggggccatg acgacggccc ggccgccgac ctctggtcgc tgggcgtggt 481 cctgtacgtc tgcacggagg gcgtcagtcc cctgcgccgc ccgacgaccc tcgccaccct 541 ggccgccgta ctcgacgacc cgctccccgc accgtcccgc tcgggcccgc tgaccccggt 601 gctcgaagcc ctgctggtcc gggaccctgc ggcccgcccg gacgccgccc gcctggacat 661 gatgctggcg caggtggagt cggggacgac accgcagtgg gccgcccagc cgacgatgac 721 cgcgaccgcg ccgcagccga cgcccactca gctggacacg ccgcgcccca cgactccgga 781 agcactgacc aggccccggc gccgtacacc cctggtggtg gccggcaccg cggtactggc 841 gatcgcggcg gccacggcgc tggtcctagc cctccgcgca ggcgacacgg ccgcggacaa 901 caaggccgac gcgacgccga aacccccggc caccacgacc gccggtccct cgaccccggg 961 gaacgagctg gaggctcccc cgacacccct ccccaccggc cccgccccgg ccggccgctg 1021 gatcgcccag ctccactccg aaccggtctc cgccggcatc gccaaccgcg accgcagact 1081 cgccaccctc cgcgagacca ttccggggac caaggtcctg cgcagcggcg actacgcctc 1141 cctgcgcgcc ggctactggg tcttctacgc ccccggcccc ttcgccaacg gccgcgcggc 1201 cctcaccttc tgcgccaagc acgaccgcac cacggcgaac acctgcatgg gccgctatct 1261 gagcaacgac gcgaccgagt tcctcctcca gtgccgccca ccggccgacg cgcctacggg 1321 ccgctgcacc cgcaagggct gagcgatccg gcggccgggt gggtgacacc ggcccggcgc 1381 acccgccgat acaccgaaat gaccgtttga tcatcatatc ttcatgcggt gatcactctc 1441 gtacgacgcg tcaccgccct ctgtgccctg ggcgcggcgc tcagtgtgct cgcctcgtgt 1501 gcggggcccg aggagatgac ccgggctccg ttgccggcgc ccagtgccac ggcctccgtc 1561 tccccctcgc tcagggctcc gacgctcgcc ccggggcccg gcggcacggc cccggtcttc 1621 gagcacggtc cccgcagcgg ggacaaggcc gtcgcgctga ccttcgacgc cgatatgacc 1681 gccgatcagg ggccacgggc ggcgcagggc gaacggttcg acaatccggg gctcatcgtg 1741 gcgctgcggg agttgaaggt gccggcgacc gtgttcatga cggggcgatg ggccgaggag 1801 tatccggagc aggcccggtc catcgggcgg gatccgctct tcgaggtcgc caaccactcc 1861 tacagccacc actccttcac cgacgactgc tacgggctgc cgaccatcgc cgaggaacgc 1921 atgcgggcgg atgtggagcg ggcgtacgcg gtgttccgga aggtgggggt gcgggacgcg 1981 atgccgtact tccggtttcc gggcgggtgc tacgaccggc gggcgctgcg ggcgctgacc 2041 ccggtcgggg tcacggcggt gcagtgggac gtggtgagcg gggacgcgtt cgcgacggat 2101 gcgggcgcgg tcgcgcgggg ggtgctggac gaggtgcggc ccgggtcggt ggtcgtgctg 2161 cactgcacgc gcagtgccgc tccgacgacg gagcgggtgg tccgcggtgt ggtgccggag 2221 ctgcgtcgtg aaggcttccg gttcgtgaag gtgtcggagc tgatccgggc ctcgggcacc 2281 cggcggtgag cgtcctacgc tggaggtatg agcgaggact actgcacgat cgccgacgcg 2341 gtgaagccgc cctgggggtc cccccacgcc cttaaggcag tgggggagga cgggccgccg 2401 tatgccgagt gtgtgctgtg ccgggagccg accgagtacc cggagtccta caaggggatc 2461 accctctgcc ccgtctgcga gtggcaggag gcacagcgca ccgcctgctc agggtgatct 2521 gcgggaggtg agcgcgcagg ccacggcgat cgccgccgcc gtgagcaggg ccgccgcagc 2581 caggggcagt acgggcatcg ggacccggcc cgagttggag ccggtgacca ggccgctcac 2641 cgccgcctgc gccggggagc ccgtcaccac caccgacagc agggccgcga gcagcatcgc 2701 cgggatcgca cggccggtgg agcgcagcag cggccaggtg gtgagcgcgc cgacggccgt 2761 gccgagcagg gcgcaggcca gtacggcgag cagcccggcc gcgcccgccg gaaggcgcgg 2821 tacgcgcgtc tggagatccg cgctcgcagg gttgctgatc agcgtcacga cgacggtggc 2881 gaccacgccc agggccaccg cggtacccag cgccaccagc agcgcggcga ggtgggcgcg 2941 cccggggccg accgccgcgg agacacaact gcgggcggcg ggcggctcgt tggtgacgca 3001 gatccgcacc agccaggcgg tgacgggcag cagcgccgcg gccgtgtagc cgagcgagtc 3061 gaggatgggc tggccgccct gcacgccgat cccgaggaac acgacgtaca ggaggaacgg 3121 cggcagccag cgctgcgagc ggacgagcag ggcggcctgg tatctgagca gggcggtcat 3181 cggcggctct cggtgtcggg gccggccggc tcctggcgca cgctcaccac gtgccagggc 3241 ggccgcgcgg tcagcagggc gcgcagcagg atgtcggagt gggacgcggg cacggtgaga 3301 cggtgggtgc cgggggccgg ttcctcggcc gcgacgacgg cgcgctgcgc gtcgccgggt 3361 agctgcccgc cgctcggccc ctgggcgacg acggtcacgc gcggcccggc ggcctcctcg 3421 ggcggttgtt cggtacggag gtcgagtccc gagtcccgca cggtgtacgt cgcgtcgggc 3481 acccccgcga gccgacgcgg atcgtggtcc acgaagacga cggcggtgcc gcccgcggtg 3541 cgttcggcga cggccctctc cagctccgcg cgggcgtcgg agtcgaggcc cgtccacgcc 3601 tcgtccagga cgagcagctc cggttcggcg aggagggcct ggacgacggc gaccttctgg 3661 ctgctgcctt tggacagctg ggccatgggg gtacgggcgt agggggcggc gccgaagcgg 3721 tcgagccact ccagggcggc acgggtggcc gcgggccgcg acaggccgtg gacggtgccg 3781 aggtgggtca gatagccgag ggcggtgaag gggagggcgg tggggaagcg ttcggggacg 3841 taggcggtac ggggcgctcc gctgacgcgg ccctcgctgg gggcgtctat gcgggccagg 3901 aggcgcagga gggtggactt gccggtgccg ttggggcctt ctatgcgaat gagggtgccg 3961 gggggcacgg tgaggtggat gccgcgtaag acccatgggc cccgtaggcc gtagcggcgg 4021 cccacgttgt ccagacgaag atcgcgttgc atgggggcat cctctcctac cgcccgggtt 4081 ggcagactgg accgtgtgaa cagtgatccc tcgatcgaca gccccttcag gtccgagccc 4141 agcacccggg acgaggcccc gcagttcgtc ctgcccctgg tcgtacgcat cgaacggtcc 4201 gctcccccgg cccgcaccga cgccctggag acctccgccc gtgccgtcct gaccatcctc 4261 agcgacgagc ggtccctcgg cgacggcgag tgggccgagg ccatgcgcga ctggcaggac 4321 gcgcggatcc gcaaggtcgt gcggcgggcc cgcggggccg agtggcggcg ggcggaggag 4381 ctgcccggga tcacggtgac cgggaagtcg gccgaggtgc gggtcttccc gccggtgccg 4441 ctggacggct ggcccaagga actggccaag ctccaggtct ccggcaccga tctcgacgac 4501 ccggaaccgc ccgtcgacgc cgatccctcc ggccccgtcc tctggcttaa ccccgagctc 4561 gacatgtcgg ccggcaagac gatggcgcag accggacacg cggcgcagct cgcctggtgg 4621 gaactgtccg acgaggagcg ggccgcctgg cgcgacgcgg ggttcccgct ggccgtacgc 4681 accgcgcagc ccgggccctg gcgtgagctg acgggcggtg ggctgccgtt ggtgcgggac 4741 gcggggttca cggagatcgc gcccgggtcg tgcacggtgg tcgcggatca tccggcgctg 4801 cggtaggcgc ggccatgcgt cttcctcctg aacgctcccg ccgtcccgcg cgtatccccc 4861 ggtacgggtc tgatgtccgg gcgggtccca acctcaaatg ttgctctgaa ggtggccccc 4921 gaggggttcg ggccgagccc gcggggccat acccccgtca cgcggaacag gcgggggcgg 4981 aagaggccga ggaggggacg atggagcgac tgggtacggg aatcggatgg cgtccggaga 5041 tcgcggacgc ggtggagcgc atgccgggca tcgactgggt cgagaccgtc gccgagaacg 5101 tctgtcccgg gcatcttccg gagtccctgg tacggctgcg tgagcgcggg gtgaccgtga 5161 tcccgcacgg cgtctcgctg ggcctgggcg gcgcggaccg ccccgacgcc gaccggctgg 5221 ccgcgctcgc cgagcgggtg gcggcactgg gggcgccgct ggtcaccgag cacatcgcgt 5281 tcgtacgggc gggcgggccg ctgacggcgt ccccgcgtct ggaggcgggg catctgctgc 5341 cggtcccccg cacccgggac gccctggacg tgctgtgcga gaacgtccgt atcgcccagg 5401 acgcgctgcc cgtgccgctc gccgtggaga acatcgccgc gctgatcgcc tggcctggcg 5461 aggagatgag cgagggacag ttcctgtacg agctggccga ccgcaccggc gtgaaactcc 5521 tcatcgacgt cgccaacctg tacaccaacc acgtcaaccg cggcgaggac ccggccaagg 5581 cgctcgccga gctgccgctg gaggccatcg cgtacgtcca tgtcgcgggc ggcttcgaac 5641 gcgacggcgt ctggcacgac agccacgccc accccgtccc ccagccggtc ctcgacatcc 5701 tgacggacct cgcgtcccga gtgtccccgc cgggagtcct cctggagagg gacgagaact 5761 tccccgaacc ggcagagctg gagggggagt tgggggcgat ccggagggcc ttggagaagg 5821 gggcggccga gcggcgcgcg tcggcgtccg ggaaccgggc cacgtcagcg gaccggcttc 5881 cgtcacccca cgagtcctcc gcacccgacc tcgcccccgc ccgtcagcgg ctcgccctcg 5941 cgcaggccgc gttgctctcc gcgctcgtcg ccgggacgcc cgtgcccgag gggttcgacc 6001 gggtgcgggt cggggtgcag gcgcgggcgc tcgcggggaa gcgggcggac gtcgtggcga 6061 aggtcgcgcc ggagttgccg gtgatcctcg gtggcgggta tcggcgggcg ttcctcgcgt 6121 acgcgaacgg gcagccgatg accgacggct atcggcgcga cgcgctggac ttcgcagggt 6181 atctgctggc cgaggggcgt tgcgaagacg tagggacgcg cgcggagttg cgggagtggt 6241 ggctggagcg gtcggggccg aagccgcggt cgcggcggcc gggggtgcgg ctggcccgtg 6301 ccacgcgtcg ggtgctgctg cgacgctgag cgggtgtcgg atacgtcagc ttccgtccca 6361 ccggtggacg cgggtggcgg cggtgagtgt gccggggtta acacctcggt ccgggacgcg 6421 ggcgacctgc ccgcttcgcc ccataatgcc gacttgagcg gcccgtcgaa cctccccgtt 6481 cgcccgtatc caccccgctt gcaaccattc cctcctgtac ggcggttggc gtaggcgccg 6541 aagcgagccg aagtaatatg ccaaccccac ccccgaagcg cactaacgtg cggtgccgca 6601 acaggaggca ccatgcgacc gcgaccgcga cccccgatca aaggccgagg catcttcagc 6661 ggcaccgggc tcatcatcac cggcctggcg gcgacgctgc tggcgatgat cttcccgatc 6721 tggtcgtacg ccgaccggtc cgggaccggt ctggacgtgc tgaacgcgga gaccgtctcg 6781 accggctacg ggccgctgtc cgccctcgac cgcgacttcc tcaccaaggt ccggctggcc 6841 gggctgtggg agctgcccgc cggtgagcag gcccggacga agggcacgac tccggccgta 6901 cggaccgccg gggagcatct catcgagggg cacgcgttcc tggacgagcg ggtgcgcgac 6961 gtcgccgcca agctcagcct cgcgctgccc aacgaggcca ccgaacagca gcggcagtgg 7021 ctggcgaccc tggactcggc ccagggcgtg gagtacgacc ggcagttcgc caacatcctg 7081 cgcctggcgc acggcaaggt gttctccgtc gtcgcccagg tccgggccag tacccgcaac 7141 tccctggtgc gcaagctcgc cgacgacgcc aacaccaccg tcctcgacca catcacggtc 7201 ctggaggcca ccggctacgt cgatttcgac gcgctggccc gggacatggt cgccgacagc 7261 acgccgccgc tcaccgcgcc gcccgccccg ccgggtccga ccgccgaccc cgctccggcc 7321 gtcccgatga ccccgccccc gtcgccgacc tacaccctgc ctccggccgc gaccagcccg 7381 cgcccgtcct gacgccccgc tcggccggat ccggaacgtc acatcccggc aactctcggt 7441 ccgcattgtg aacaaggcat ggtgttcgac ggagcatctg gcatagaaac acggcatgtt 7501 ctgggtgctt cttctgctgc tggcctgggc cgtcgccggc acggcgtgca cgcggctgtg 7561 cctggccgcc gtgcaaaccg cggccatgga aaggaaagag gcgaccacgg cccgggacca 7621 cgatctgacg ctgtacgagg ccgcgttcct gtccggcggc ccccgccggg tcgccgatct 7681 gaccctcgtc tccatggccc ggcagcagcg gctgctgctc gcgcacaccg gctgggcgac 7741 ggtcgtcgat ccgcgcggcc gggacgagat ggagcgctcg gtgatagggg ccatcgggcc 7801 ggagggccag tcccggatcg agccggtgcg ggacgccgcg gccgccgccg aggccgtggg 7861 cagcctcgcc gaccggctgg tcagcgcggg gctcgcggtg cccgacgcgg cgcgtgacgg 7921 catcggttcc gcgatccgcc aggtgcggct cgccgcggcg gtcgtcctgg cgctcggcgc 7981 cgtcgcgctg ctggcgcccg cccagtcgga catgccggcc catctggtcg ccctctggtt 8041 cgcgctgccc ttcgtcctca ccctgagctg tctggccatc gcccgcgtcg agatccaccc 8101 gtacgcgcag tgggcctccc cggccgggca gcggctgctg agcggcctga tccggcgctc 8161 cgggggcggg gacgaccgta cgtatctgac cttcgtcgcc gtacggggcg tgcgagcggt 8221 cggcgaaccg gaactgcgtg cggccttcgc acatcgcgcg cacggggcgt cgcactggcc 8281 cgactgacgc ggctccgggg cgggccgggt cgcggagttg gtgacgcata gggggcaatg 8341 cggcaacttc ggcgaggcgg tgcttgcctt catcaacaga cgaacgaaat atcccttttg 8401 ttgctgccgt gcaccgaagg gatacccgat gagagctgcc gccctctact cggccgcggg 8461 ggccatgctc ctgtccgccc tctccctggc cccggccggc cacgccggtg ccgcaccggc 8521 cgccgacgaa cagcgcggca cggcggtggc cgccgcgcgc gccagggccg ccggcatcga 8581 cttcgaccgg tgccccaagg accaggggct gccgggccat gtgcggtgcg gcacggtgtc 8641 cgtcccgctg gactacgcgc ggcccgacgg caagcagatc cggctcctgg tcagccgggc 8701 gccggccacg cacaaggacc cgcacaacag caagcaccgg gtgcccggca agggcccgct 8761 ggtctacaac ccgggcggac cgggcgcgtc cggccttcag ttcccgctga tcggggtcct 8821 cccggcgtgg aagcggctgg ccgcggccta cgacctggtg ggctacgccc cgcgcggggt 8881 ggggccgtcc gcccggctgt cctgccagga ccccaagcac tacctcaagg ggcccgcgca 8941 ggcaccgacg tacccctcgg agtcgtacaa gaaggagcgc gtcgcccgcg ccaaggccta 9001 cgcacgcggc tgcgccgagc gcgccgggag cgccctgcag tactacaact ccctcaacaa 9061 cgcccgtgac ctggacgtcc tgcgggccgc gctgggccag tcgaagctga cgttcatggg 9121 cgcgtcgtac ggcacctact tcggggcgct gtacgcgcac ctgttcccgt cgcatgtacg 9181 gcggatggtg ttcgactcgg cggtgaaccc ggaccccaag cagatctggt accacaacaa 9241 cctggcccag tcggccgcgt tcgaggggcg ctgggcggac ttccgggagt gggtcgccga 9301 gcacgacgac gtgtacgggc tcggcatcac ggccgccgag gtgctggaca actacgacga 9361 ggtgcgcacc cggctggcct cggagccggc gggcgggaag atcgggccgg ggcagctgca 9421 ggaggcgttc ctgcaggccg gttactacga cgactactgg ccctcgcggg cgcacgcgct 9481 gtcggcgtat ctgaagggcg acacgaagcc gctggtcgag ctggcctcgc cggcgacgga 9541 ggcggcggcc gaggaggaga acacgaacgc ggtctacacg gccgtggagt gcaacgacgc 9601 gccctggccg acggactggg cggtctggga ccgggacaac acccggctcg cgcgcgtggc 9661 gccgttcgag acctgggaca acgcctggat gaatctgccg tgcgccttct ggcaggcgcc 9721 caggcagcag ccgctggatg tgcggaccgg gccgggtgag ctgccgccga cgctgatcct 9781 ggccgccgag cgggacgccg ccacccccta cgacggggcg ctggagatgc accggcggct 9841 cgcgggctcg gtactggtga ccgagcggga cgccgggacg cacggcatcg cgtacgggcc 9901 gaacaagtgc gtgaacggct acgtcgacgc gtatctgctg gagggccgtc tgccgacgcg 9961 gcacgcgtcg tgcgaggggc accccgagcc gaagccgcag cgggcgggcg agcgcaagac 10021 gaagaagtcg gccgcgcagc acaaggaccg gcacgagacc gcggcccgtc catagccgtc 10081 cgggctcaca cggcgaagcc ccgcaccccg tcgaggggtg cggggcttcg tcgtacgtcg 10141 gtctaggcga gcccggcgac cagctcggcc acggacttgc ggcggccggt gtagaacggc 10201 acctcctcgc ggacgtgcat ccgggcctcg gaggcacgca ggtgacgcat gaggtcgacg 10261 atgcggtaca gctcgtcggc ctcgaaggcg aggatccact cgtagtcgcc cagcgagaac 10321 gaggcgaccg tgttggcgcg gacgtccggg tagccgcggg ccatcttgcc gtggtcggcg 10381 agcatacggc ggcggtcctc gtcgggcagc aggtaccagt cgtaggagcg cacgaagggg 10441 tagacgctga cgtagttgcg cggcgtctcg tcggcgagga acgccgggat gtgcgagcgg 10501 ttgaactcgg cggggcggtg cagcgccatg ttcgaccaga cgggctcaag ggcccggccc 10561 agcttggtgc ggcggaagag gttgtacgcc tcctggagct ggtcggcggt ctcggcgtgc 10621 caccagatca tgaggtcggc gtcggcgcgc aggcctgaca cgtcgtaggt gccgcggatc 10681 gtcacgtcct tggcggcgag ctggtcgaag agctcctgga cctcgtcggc gtagcccgcg 10741 cggtcctcgg ggagcacgtc cttcagcttg aagacggacc agagggtgta gcggatgacc 10801 tcgttgaggt ccttggccag cttgcccttg ttcgggatcc gaccgggctc ggtggtgggg 10861 gcgtcgtcac tcatgtccct attctcctgc tcctccgtgg agactctgca ccgggttggc 10921 ggtgaggtcc tgcacaccgc tcaggtctcc gtccagctgg tccacggcgg cgtacgcgct 10981 cgcgatgcac gccgggatgc ccacgccgtc gtactgcgcg ccgcacacgg cgaggcccgg 11041 caccttggcg atgtgctcgc ggacgcgggc cacgcgcgcg tggtggccga ccgggtactg 11101 gggcagaccg tcggtccagc gggtgacgcg ggtccggacg ggggtggcgt cgaggccggt 11161 ggcctgcttc aggtcgcggc gtgagacgtc gacgaggtgg gcgtcgtcgc ggcccaggat 11221 gtccgtctcg ccgtaccgtc cgacggaggt gcgcaggacc agcgtgtccg ggtcctcgtc 11281 ggcgatccag ccccacttct gggaggcgaa cgtcgatgcc ttgatggtg //