LOCUS       NZ_BNBM01000001        26451 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000001
VERSION     NZ_BNBM01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1203604)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 972087
            Orig. end                         :: 998538
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26451
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="butyrolactone"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..26451
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22160
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22160
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12160](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12160)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(336..887)
                     /locus_tag="IE325_RS04295"
                     /old_locus_tag="GCM10018780_08710"
     CDS             complement(336..887)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062766.1"
                     /locus_tag="IE325_RS04295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08710"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_190068277.1"
                     /transl_table=11
                     /translation="MTSSFEFNTYPARLSDAERDKALKVLRDGVAMGRLSHDTFVRRME
                     LALAARRSDELAVLTADLPSESKLSRLVFGTVEAVSGFTVRLRRAWQAERLPKLLLPHP
                     ATGHPLRIGRDPANGLRLTHETVSRVHAELSHQGGLWVLRDLGSTNGTTVNGRRVIGAV
                     VVREGDQVGFGRMSFRLAAT"
     gene            1020..2765
                     /gene="treZ"
                     /locus_tag="IE325_RS04300"
                     /old_locus_tag="GCM10018780_08720"
     CDS             1020..2765
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431956.1"
                     /locus_tag="IE325_RS04300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08720"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_190068278.1"
                     /sec_met_domain="Alpha-amylase (E-value: 4.4e-12, bitscore:
                     42.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLHCEGATRALERDTDRAGWWWGEADARDGTR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHESHEWRTEWAGRPLPGAVLYELHVGTY
                     TCEGTLDAAAGRLEHLAELGVTHVELMPLSPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHELGLGVVLDVVHNHFGPSGNYLPLFGPYLTDTHQTPWGAAVNLDAPGSDEVR
                     AYLVQSALAWLRDYRIDGLRLDAVHALKDTRACHFLEELSTAVDALSADLGRPLSLIAE
                     SDLNDPRLITAREEGGLGLHAQWNDDFHHTLHTALTGESQGYYADFGRAPLAGLAKTLT
                     GGYFHDGTYSTFRGRRHGRPLDRTRVAAHRLLGYGQTHDQVGNRAQGDRLAATLSPGLL
                     ACAATLTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDPELADAVRRGRRREFAAHGWAEE
                     DVPDPQDPATRERSCLDWSELDGEPHARVLAWYRRLIALRHEQPDLTDPDLADTKVAYD
                     EQQRWLAFRRGDVRVAVNLAKEPAAIPLGPRKAAVLAAWEPVEAPGADGVLEVPGESGV
                     VLLQG"
     gene            complement(2817..3743)
                     /locus_tag="IE325_RS04305"
                     /old_locus_tag="GCM10018780_08730"
     CDS             complement(2817..3743)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996925.1"
                     /locus_tag="IE325_RS04305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08730"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_190068279.1"
                     /sec_met_domain="APH (E-value: 3.2e-16, bitscore: 56.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLKDGVDDSAGPEVRPAAPGAQPATWW
                     VGTRHVLRLAPDREATARQRRELRLRDLVRPHVPVALPTSVAYGEWAPGLTYTLDSKVP
                     GGSGTRYDVSAVGEADLAGLLTGLREVPVRQAEALGVPRTAPRSLEALRRAAERPAARL
                     ADADEFDATRLRQLTQPGAVQLAAQPGTAVLVHHALTADHLVVSADGRVRGILGWADTV
                     LGDPAEDIAGLALAVGSPAAVRAATLAGYGARPCLRGLWLARCDAVLDLAARLDGTGET
                     PLPLLRQRLGHAWEAILLERVTELRED"
     gene            complement(3805..4932)
                     /locus_tag="IE325_RS04310"
                     /old_locus_tag="GCM10018780_08740"
     CDS             complement(3805..4932)
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="IE325_RS04310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08740"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_190068280.1"
                     /transl_table=11
                     /translation="MTGTAPAPFTADDYRARMERAARAAADAGLAGLLVAPGPDLVWLT
                     GYAPTAETERLTLLVLVPGRDPILIVPALEAPDAAKASGAPGLNLRDWTDGKDPYAATA
                     ALLDPSGRFGISDNAWAMHLLALQRALPGTSYASLTDALPMLRAVKDAAELELLAAAGA
                     AADATFEEIRKVPFGGRRESEVAADLAHLLRRFGHSQVDFTIVASGPNGANPHHEVGDR
                     AIERGDMVVLDFGGLKDGYGSDTSRTVHVGEPTDEERRVHDLVREAQEAGFRAVRPGVA
                     CQEVDRAARAVIADAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGV
                     YLPGRFGVRIEDIVTVTEDGGRRLNDTTRELVIVD"
     gene            complement(5040..5660)
                     /locus_tag="IE325_RS04315"
                     /old_locus_tag="GCM10018780_08750"
     CDS             complement(5040..5660)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657042.1"
                     /locus_tag="IE325_RS04315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08750"
                     /product="LysE family translocator"
                     /protein_id="WP_190068281.1"
                     /transl_table=11
                     /translation="MPTTLIAFLGACTLVAASPGPSTVLIIKQSLQSRRSGFLTVLGNE
                     TGVFIWGLVAAFGLTALLTASEMAYDVIRVVGAVVLVGFGVQALRQARRANGAGETTWE
                     STPKSGWASYRGGLLLNLANPKAAVFAMSFLPQFVPQGAPHLPTMIGLAALWAVYEVGY
                     YGLYVWFVGRLRSVLSRAGVRRRLEQVSGGVLLLLGVRMALEG"
     gene            complement(5768..6346)
                     /locus_tag="IE325_RS04320"
                     /old_locus_tag="GCM10018780_08760"
     CDS             complement(5768..6346)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657043.1"
                     /locus_tag="IE325_RS04320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08760"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_190068282.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQGPGEGATSDPGARRPHAAPRRRGRRLTTLWC
                     ALLAGLVLLLSGVGLGTVGATVIGMSRLAELQRQAGHRAPGNPATPSHSPAPVSSPSPA
                     VVATLGVEAVDDDGPGALIVGVHVPGPGYTAGLVRGDLLLAFGRTRIDSAADLARAVAR
                     SRPGDGINLTVRHRSGGYQQLTVVPGVVT"
     gene            complement(6456..8336)
                     /gene="phsA"
                     /locus_tag="IE325_RS04325"
                     /old_locus_tag="GCM10018780_08770"
     CDS             complement(6456..8336)
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675701.1"
                     /locus_tag="IE325_RS04325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08770"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_190068283.1"
                     /transl_table=11
                     /translation="MTDIIERFTDSDAKAETEQPLHTGELTPYVAPLPVPTVLRPASGD
                     VLRETEIALRPTWVRLHPQLPPTLMWGYDGRVPGPTIEVRRGQRVRIAWTNRIPKDSEY
                     PVTSVEVPLRTDGRPQSTTEPGREGVEPNKDVAALPAWSVTHLHGAQTGGGNDGWADNA
                     VGFGDAQLSEYPNDHQAVQWWYHDHAMNITRWNVMTGLYGTYLVRDDEEDALHLPRGER
                     EIPLLLADRNLDTDEDGRLNGRLLHKTVIVQDKNPETGKPVSIPFTGPYTTVNGRIWPY
                     ADVDAAWHRFRLVNASNARTYDLVLIDEDDNPVPGVVHQIGSDGGLLPRPVPVDFDGAL
                     PTLTAAPAERFDLLVDFRGLAGRTLRLVNKGANQPPGVPDPAGDVRYPAVMEFRVRETC
                     EADTFELPEVLSGSFRRLTHDIEHGHRLIVLTPPATKGGGGHPEIWEMTEIEGADIQVP
                     TEGVIQVTGPDGKTKTYRRTARTFNDGLGFTIAEGSHEQWSFLNLAPIVHPMHIHLADF
                     QLLGRDAYDVSGFDPAIGGTRGPIRHDAGTTIPLAPNERGYKDVFRVPGNQMLRVMGRF
                     DGAYGRFMYHCHLLEHEDMGMMRPFVVMPPEALKFDHGGGHGGHGGGHTG"
     misc_feature    complement(8220..8222)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8323..8336)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     gene            8501..9979
                     /locus_tag="IE325_RS04330"
                     /old_locus_tag="GCM10018780_08780"
     CDS             8501..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071448.1"
                     /locus_tag="IE325_RS04330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08780"
                     /product="hypothetical protein"
                     /protein_id="WP_190068284.1"
                     /transl_table=11
                     /translation="MTDRALRLLRQHQHLAELAAFPFNFDLARAAHGHVEEVRLASGGP
                     LEVVAGDDTGGTYFVCADGSVLHADSEGSAGIIGSSVAEALEIMIGLAEVEDEDDEEGS
                     DGRDELEQARAELRAAFGFPQRSVAELEAMLRAALLRTEPDFVLLNDLEHNAYQLLDTY
                     PRPPLWEPVLATGRADLAMLRSGGRTAWEEVAEDALRRRLALRAAQFDRAEGDLELLRH
                     LLRQEARSSMTEELRLAAVLVGLHGDPADLSLLHEVRETDFDTACGLGGMPEPGASSEE
                     LRDWAVELDESLFGTDPSDEPVSTWTDLARDQGMTELARVTLIRELDEIFMDQSRLRRP
                     DAPRALATAPLRALARDFEELGDLPQALRAQRLYAALQETAWDRASALHTQALLERESG
                     QLSEATGTLAAVRDALATPGDDSLRHWQSVNLGRFLTEEHYRLTRALADANRPEDARAL
                     LAAADAILGELSENAANGIRELAEETAARVREVG"
     gene            complement(10001..12160)
                     /gene="cyc2"
                     /locus_tag="IE325_RS04335"
                     /old_locus_tag="GCM10018780_08790"
     CDS             complement(10001..12160)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133697.1"
                     /locus_tag="IE325_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08790"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_190068285.1"
                     /sec_met_domain="T1TS (E-value: 1.9e-79, bitscore: 264.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQPFELPHFYMPYPARLNPHVDEARAHSTEWAREMGMLEGSGI
                     WEQADLEAHDYGLLCAYTHPECDGPALSLITDWYVWVFFFDDHFLETFKRTQDRAGGKA
                     YLDRLPLFMPMDLSAPMPEPQNPVEAGLADLWTRTVPTMSADWHRRFSVATEHLLNESL
                     WELSNINEGRIANPVEYIEMRRKVGGAPWSSGLVEYATAEVPASVAESRPLRVLMETFS
                     DAVHLRNDLFSYQREVEDEGELSNGVLVLETFFDCTTQQAADLVNDVLTSRLHQFEHTA
                     LTEVPAVALEHGLTPAEVAAVASYAQGLQDWQSGGHEWHMRSSRYMNARAEPTTPWRGL
                     TGPGTSAADVGALLASAGAERLRAYTHVPFQKVGPSLLPDFHMPYQCELSPHLAATRVR
                     LTDWMHRMGMLQEGVWDEDKLAAYDLALCSAGLDPDGTPEALDLSARWLAWGTYGDDYY
                     PLVFGHRRDLAAARLTTQRLSDCMPLDGEPPIVPANGMERGLIDLWAHTTAGMTADERR
                     AVKDSVDVMTESWVWELSNQLQNRIPDPVDYLEMRRATFGADLTLSLCRMGHGPAVPSE
                     VYRSGPVRSLENAAVDYACLLNDVFSYQKEIEYEGEIHNSILVVQNFFGVDYPTALHVV
                     HDLMTQRMQQFEHVAAHELPIVYEDFGLSEEAREIMENYVVDLQNWMAGILNWHRTVPR
                     YKAEYLARRAHGFLPDRAPAVPVLG"
     misc_feature    complement(12266..12277)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            12342..13583
                     /locus_tag="IE325_RS04340"
                     /old_locus_tag="GCM10018780_08800"
     CDS             12342..13583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996933.1"
                     /locus_tag="IE325_RS04340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08800"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_190068286.1"
                     /transl_table=11
                     /translation="MTPTGSLSRRTALASLAGAALATTAALPASASERHGRRSVRFATF
                     NASLNRGTQGALITDLSTPDNVQARNVAETIQRVDPDVLLINEFDYDEQGSAVRLFLRN
                     YLAVGQRGAAPVRFPYHYTGPVNTGVATGVDLDGKNGAVTTPGSDAYGQDAYGYGWFPG
                     QYGMVVLSKFPIDTRAVRTFQRFLWKDMPGNIMPPGYYSDEARAILRLSSKSHWDVPVC
                     IGHDTVHFLVSHPTPPTFDGTEDRNGRRNHDEIRLWADYVGGRRRGSYLYDDKGRRGGL
                     RVGARFVIAGDNNADPYDGDSYDHAILQLLDHPAMNLPAVPPASAGGVEAARVQGGANA
                     AHRGDPAYDTSDFGDTAPGNLRVDYVLPSKGLVPGGNGVFWPTSDDPLYRLVGDGVSVP
                     TSDHRMVWQDVRVG"
     gene            complement(13722..14471)
                     /locus_tag="IE325_RS04345"
                     /old_locus_tag="GCM10018780_08810"
     CDS             complement(13722..14471)
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118853.1"
                     /locus_tag="IE325_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08810"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_190068287.1"
                     /transl_table=11
                     /translation="MLRLDEVGQHYGDHQVLHDITLTVPDGQLLCVVGPSGCGKSTLLR
                     TVAGLLPTYDGTITLDGTPVRGVPDNLAVVFQDYARSLYPWLTVRENVALPLRRRGLPR
                     NERRAEADRILARVGLTDTARRHPWQLSGGMQQRVAIARALVCRPSLLLMDEPFGSLDA
                     QTREDLEDLLLEVHRTDGATIVFVTHDIDESVYLGDRVVVLSPGPAAKIVLDLPVELPD
                     TRDQITTRGLTEFVTLRSEVGRAVRKR"
     gene            complement(14509..15288)
                     /locus_tag="IE325_RS04350"
                     /old_locus_tag="GCM10018780_08820"
     CDS             complement(14509..15288)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071443.1"
                     /locus_tag="IE325_RS04350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08820"
                     /product="ABC transporter permease"
                     /protein_id="WP_229911666.1"
                     /transl_table=11
                     /translation="MRHALLRWTVLVLAVVVWQLVAGAHGSVYFPPPVEIAGHALDLWF
                     SGPARHVFLTEAAVGDILPSLGRMAAGFGIAAVAGIALGVAIGRSRRVYALCDPVLQFA
                     RAVPPPALVPVFVVILDFGTPMQIASIVFSAIWPVLINTAEGARDTDPLRIEVAAVLRL
                     TPVERLRFLILPSALPRIFAGLRLSLSLSLILMVFSELLPGTANGIGFTLTDAQSRSDL
                     LTVWSALVLLGALGYLLNTGLLAVEKRLIGKGRTTTV"
     gene            complement(15383..16162)
                     /locus_tag="IE325_RS04355"
                     /old_locus_tag="GCM10018780_08840"
     CDS             complement(15383..16162)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058066.1"
                     /locus_tag="IE325_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08840"
                     /product="ABC transporter permease"
                     /protein_id="WP_190068289.1"
                     /transl_table=11
                     /translation="MKARQEQFLLGGLGVLLAVGACEAVSRSGLVRRSYLPPASEVLAR
                     AVELAGDSVFLDGIAATLRAWALGLALAIGIAVPVGLVLGSVPVVDAAVRAIVEFLRPL
                     PSVALIPLVSLLLGSGTETKVALVTYASVWPILFNTIYGLAETDPLAKDTLRAFGFGRV
                     GVLLRVELPGTAPFIAAGIRISAAVALILAVATEILSGFGEGLGIFIAQAGLATDGTRD
                     VLAGVVWAGGLGLVINGVLVWGERRLFPWTPGRRGVG"
     cand_cluster    15501..26451
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    15501..26451
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[20500:21451](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(20501..21451)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     gene            complement(16164..17072)
                     /locus_tag="IE325_RS04360"
                     /old_locus_tag="GCM10018780_08850"
     CDS             complement(16164..17072)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431983.1"
                     /locus_tag="IE325_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08850"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_229911639.1"
                     /transl_table=11
                     /translation="MAVTACGGDGDSSSGAGGRETVRVAALPLIDCAALYIAQERGLFE
                     KEGLDVRIQQIQQSLQALPALAKGQIDMVASANYVTYLQAHEKGTLDIRIVAEAIRAAP
                     RMMEVLVPEDSDIKSVADLAGKKLAVNVLNNVQSLTFDEIVEKQGVGKPVYRAIPFPQM
                     GAALDKGQVDAVHAVEPYDSAIQDELNARVLVDGSSAPVEAIPLSGYISTGAYADGHGR
                     TLAAFQRAIKAAVEIAEKDPSVVRDTLPTYTKVTEEQARSIDLPVFPPAMDAAQLTRLT
                     DLMKKQGMLKKPIDPATLLVK"
     gene            17229..18527
                     /locus_tag="IE325_RS04365"
                     /old_locus_tag="GCM10018780_08860"
     CDS             17229..18527
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645378.1"
                     /locus_tag="IE325_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08860"
                     /product="cytochrome P450"
                     /protein_id="WP_190068291.1"
                     /sec_met_domain="p450 (E-value: 1.3e-18, bitscore: 63.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASSPVPDTPAPDSPALDTPAPDVFDPRQYATGVPYPAYRILRDH
                     HPVARQDEYEVLGWPAGPGFWAVTRHADVVRVLKDSATYSSRLGATQIRDPDPEDLPFI
                     RRMMLNQDPPGHGRLRRLVSRAFTPGRVDRFVGVAEERARSLLAQALDTARATDGTVDL
                     VTAVTDDYALLNLADLLGVPEADRGLLLHWTQRVIGYQDPDEAGPQVLDGEGRPVNPRS
                     PAMLRDMFAYARQLAAHKRRFPADDVMTTLANDPELDGPELEMFFFLLTVAGNDTVRSA
                     APGGLLALAEHPKSYERLRTRDVELPAAVDELLRWHPPVLTFRRTATRDAELAGQRIRA
                     GDKVVVFHASANRDERVFADPDRLDLSRSPNPHVSFGDGPHVCLGAHFARLQLRVLYRE
                     TVRAAPVLRKAGEPKRLVSNFINGIKSLPMHVT"
     gene            complement(18561..19748)
                     /locus_tag="IE325_RS04370"
                     /old_locus_tag="GCM10018780_08870"
     CDS             complement(18561..19748)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981894.1"
                     /locus_tag="IE325_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08870"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_190068292.1"
                     /transl_table=11
                     /translation="MPERSDTPPASVLLGNEPGSFPHSVLAERHPAIISQVRDSFPYDP
                     ERHRALDALLASCTKGVIEPLPADAHDRDRWAAWGAEAYTGRSWFDVPWLWSESFFYRQ
                     LLEAVGYFTPGPWLGIDPFRPSKLAELNAPETDEELAALDPLAERPTDEQDRALLHGSL
                     WGNRADLGFRLSAAQAATASDTPPLVSDDSETLWSLLPPSGTATLCLIADNAGRELIPD
                     LLLIAHLLTQGRIGRAVLHIKPYPYYVSDATHADVLDALRRLTSAPGAAADYGRTLWSA
                     ITDGRLAVRAHPFSSAPLPYAEMPADLRGELATATLTVLKGDLNYRRLVGDRLWPPTTP
                     FLDVTAYFPGSVAALRTLKSDVITGLDARTEAALVAAEGQKWRTGGTHALIQVRG"
     gene            complement(19780..20427)
                     /locus_tag="IE325_RS04375"
                     /old_locus_tag="GCM10018780_08880"
     CDS             complement(19780..20427)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996936.1"
                     /locus_tag="IE325_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08880"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190068293.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRTTILTAAAELFDRHGYESTSLSDIVEHAQVTKGA
                     LYFHFAAKEDLAQAIMELQSRASRQVAGEMEARGHTSLEALIRTTFGITRLAVEGPITR
                     AGLRLATGGVVIRPPLRHPFNELLDIATRRLHGAAREADIHPDVDTEAAAHALVCFFVG
                     TRVVGRSLEPVARQPRRVAEMWHLMIRGLVPVPRRARYLALATQLEREIKTV"
     misc_feature    complement(20413..20415)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20501..21451)
                     /locus_tag="IE325_RS04380"
                     /old_locus_tag="GCM10018780_08890"
     CDS             complement(20501..21451)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133701.1"
                     /locus_tag="IE325_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08890"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_190068294.1"
                     /sec_met_domain="AfsA (E-value: 1.2e-22, bitscore: 75.9,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPRHLSTAPLAATPEAPHGLTATVPRQLVHRASLAETFLTGVT
                     SIDTDRFTVFAEWPRAHQLHVSPDRSAYEPLLVAETARQAGALLAHTAYDVPLGHQFVL
                     RELRIATRPERLALGPAPAAPVLRITVTDVEHRGGRPAGFRYDTDVLLDDERVATAQVA
                     VAWTSAAVYRRLRGGRNATTVSALPVPRGLAPAVVDRALPGDVVLAPTGRTDRWQLRVD
                     TAHAVFFDHPLDHVPGMLLLEAARQAVRARPGSGRRTPASFRAVFHRYAELDLPAWIET
                     AGKEEANGGDGSDVQVLGRQGKSTVFECEVGTVDG"
     misc_feature    complement(21260..21262)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21646..22323
                     /locus_tag="IE325_RS04385"
                     /old_locus_tag="GCM10018780_08900"
     CDS             21646..22323
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996938.1"
                     /locus_tag="IE325_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08900"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_190068295.1"
                     /transl_table=11
                     /translation="MARQERAIRTRRVILEAAGAVFDEHGYTATTISMVLERAEVTKGA
                     LYFHFPSKESLAQAVLDVQIPLGAVPPQPCKLQELVDVTFVFGRRLLHNSLLKGSVRLA
                     VDQCAPPGVDHSGPFRQWADHLVVVLEQARDQGELLPTVEPRQTVELLVGAFAGVQLMS
                     RALTDRADLAERISVLWGHLLPSIAVPGVLTGIDRDPDRGLRVLAAIGESDDEQADLDL
                     FCR"
     gene            complement(22465..24273)
                     /locus_tag="IE325_RS04390"
                     /old_locus_tag="GCM10018780_08910"
     CDS             complement(22465..24273)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122073.1"
                     /locus_tag="IE325_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08910"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_190068296.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.9e-51, bitscore:
                     171.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSTSLRRKLISVAAVSAALFTAATTTAAVAQDSPAPEAAVPVA
                     QAEAAPGTPAERLIVGYKSGAAEAKSNKAAEADAAAKGGEAGENLDFQRRLGSGAALVD
                     LGANLTRADVADVVAEYQADPQVAYVVPDRLNKPLATPNDTEYSKQWDLFESTAGMNVP
                     GAWDVATGSGVTVAVIDTGYVTHSDLGANIVAGYDFISDATVGNDGNGRDSNPADPGDW
                     TAANECQAGAPATTSSWHGTHVAGTIAAVTNNGKGVAGIAHGAKVSPVRVLGKCGGYDS
                     DIIDAITWASGGTVSGVPANANVAKVINMSLGGGGACSTATQSAINAAVNRGTTVVVAA
                     GNSNDNAANYSPASCGNVVSVAAADRQGNRSYYSNYGSIVDIAAPGGETNSVTSNGILS
                     TLNSGGQGPSSESYQYYQGTSMAAPHIAGLAALMKSANTSLTPAQIESAIKTNSRTLPG
                     TCSGGCGAGLADAAKTVQAVSGGSGGSTGGTTFTSTSAVSIPDNGSAIESPITVSGRSG
                     NAPSALQVGVDITHTYRGDLVVDLVAPDGTTYRLKSASSSDSADNISTTYTVNASGEIA
                     NGTWKLRVQDTAAQDTGRLNSWKLTF"
     misc_feature    complement(24270..24283)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            24651..25583
                     /locus_tag="IE325_RS04395"
                     /old_locus_tag="GCM10018780_08920"
     CDS             24651..25583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062782.1"
                     /locus_tag="IE325_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08920"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_190068297.1"
                     /transl_table=11
                     /translation="MPWMRSHRSALAAAAVTPLLLTVWAAVPARAHGAPTDPVSRVYAC
                     SPEGGSASDSTACRAAVAANGTPFTAWDNLRIANVNGRDRQVVPDGKLCSGGLPAYRGL
                     DLARADWPSTRLAPGASLTMRYVSTIPHTGTFRLYLTKPGYDPAKPLTWSDLPDRPFAE
                     VKDPALTDGAYRLTAKLPSDRSGRHVLFTIWQNSSTPDTYYSCSDVVFPDRESAGKEAD
                     GDADRDNGRTAAASSPAKEPRTSEPRTADPTPTASAPAETARTQGDSTPVASTGAADSG
                     PSTPLLAGGAAAVLVLTGGAALALRLRRR"
     gene            complement(25602..26255)
                     /locus_tag="IE325_RS04400"
                     /old_locus_tag="GCM10018780_08930"
     CDS             complement(25602..26255)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="IE325_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_08930"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_190068298.1"
                     /transl_table=11
                     /translation="MRTRTLLTLAGTVAALTLPLAGPASAADGAVLTTGSVGGTAVAAG
                     EVLTAPLASGTAATFYSSATGTSGISCTSSQFTASVTDNPGAPGTATESVSAHTFDAAS
                     CTTNVVGVLGVTSITVNNLPYSAAVASDGTVTVTPAAGSTIQTTVVLRTLLGSINCVYQ
                     APSLTGTASNDDNTINFNRAAFAKVSGSSLCFANGYFTAKYAPVTASGAAVYVN"
ORIGIN
        1 gcggtcctgc cacgacgagg gcctggcggc tgccgtggcc cacggacagc agccacaggg
       61 gggtgcccgc gcgggaggtc ccgacccggc gcagccgggt gtctcggggg cggcgggcga
      121 ctagcgcggc cgcccgggca cccagctcgt cgacggtcgg gtagcggagg agtggcggca
      181 gggcacacct ccacaaatgt ggtgccgtcg gttcacctga tgtgcatggt gtacgcacag
      241 tcagtcacga cttgacgact acgtcaacac cgtagaaggc aaagggactt gcctcgatcc
      301 gtccacgtac ggccgaggcc agggccggga ttggctcagg tggcggcgag ccggaacgac
      361 atccggccga agcccacctg gtcgccctcg cggaccacca cggcgccgat gacgcgccgg
      421 ccgttcacgg tggtgccgtt ggtggagccg aggtcgcgca ggacccacag gccgccctgg
      481 tgactgagtt cggcgtgcac ccgggacacc gtctcgtggg tgagtcgcag cccgttggcg
      541 gggtcgcgcc ctatgcgcag cggatgtccg gtcgcggggt ggggcagcag cagcttgggc
      601 agccgctcgg cctgccaggc cctgcgcagc cgtacggtga agccggagac cgcctccacg
      661 gtgccgaaca ccagacgcga cagcttgctc tcggagggca ggtcggcggt gagcacggcg
      721 agctcgtccg agcggcgggc cgcgagggcc agctccatgc ggcgtacgaa cgtgtcgtgc
      781 gacagcctgc ccatggcgac gccgtcacgc agcaccttca gcgccttgtc gcgctccgcg
      841 tcggacagcc gcgcggggta cgtgttgaac tcgaaagacg acgtcacggt gctgattgtc
      901 ggtcagtgaa cctcgggtgt ccagaaaacg gggaaacggc cgccacgtgc gcgtgcccgg
      961 cctgtttgaa gcaccatgga cgggctacat cacggtgagc cgacgaaggg gaaccgtccg
     1021 tgcagttcga ggtgtgggca ccgcaggccg accgtgtgac gctccattgc gagggcgcca
     1081 cgcgtgcgtt ggagcgcgat accgatcgcg cgggatggtg gtggggggag gcggacgcgc
     1141 gggacgggac acggtacggc ttcgcgctcg acgacggccc cgtcctgccc gatccacgct
     1201 cgcgccggca accggacggc ccggacgggc tgagcgcggt cgtcgaccac gagagccacg
     1261 agtggcgtac cgagtgggcg ggccggccgc tgcccggagc ggtgctgtac gagctgcatg
     1321 tgggcacgta cacgtgtgaa ggcacgctgg acgcggcggc cgggcggctg gagcatctcg
     1381 ccgaactggg ggtcacccac gtcgagttga tgccgctgag ccccttcccc ggccgccacg
     1441 gctggggcta cgagggcgtc tcgctgtggg ccgtgcacga gccgtacggc gggcccgagg
     1501 cgctgaaacg cttcgtcgac cgggcgcacg aactcggcct gggcgtggtc ctcgatgtcg
     1561 tccacaacca cttcggcccg tccgggaact atctaccgct cttcggcccc tacctcacgg
     1621 acacccatca gacgccctgg ggtgccgccg tcaacctgga cgcgcccggc tcggacgagg
     1681 tgcgcgcgta tctcgtccag agcgcgctgg cctggctgcg ggactaccgg atcgacgggc
     1741 tgcgcctcga cgcggtgcac gcgctgaagg acacacgcgc gtgccacttc ctggaggagc
     1801 tgtcgacagc cgtcgacgcg ctctccgccg acctgggccg cccgctgtcg ttgatcgccg
     1861 agtcggacct gaacgaccct cggctcatca ccgcgcgcga ggagggcggc ctcggactgc
     1921 acgcccagtg gaacgacgac ttccaccaca ccctgcacac cgcgctgacc ggcgagtccc
     1981 agggctacta cgcggacttc gggcgagcgc ccctggcagg cctcgccaag accctcaccg
     2041 gcggctactt ccacgacggc acgtactcga cgttccgggg ccggcgccat ggacgccccc
     2101 tggaccgcac gcgggtcgcg gcgcaccgcc tcctcggcta cggccagacc cacgaccagg
     2161 tcggcaaccg ggcccagggc gaccggctcg cggccaccct ctcccccggg ctgctggcct
     2221 gcgcggccac gctgacgctg accgcgccgt tcacgccgat gctgttcatg ggcgaggagt
     2281 gggccgcggg cacgccctgg cagttcttca ccgaccacac cgatccggag ctggccgacg
     2341 cggtacggcg tggcagacgg cgggagttcg cggcgcacgg ctgggccgag gaggacgtgc
     2401 ccgacccgca ggacccggcg acccgggagc gctcctgtct ggactggtcc gagctcgacg
     2461 gcgagcccca cgcgcgcgtg ctcgcctggt accgccggct gatcgccctg cgccacgaac
     2521 agcccgacct gaccgatccc gacctcgccg acaccaaggt ggcctacgac gagcagcagc
     2581 gctggctcgc cttccgccgc ggggacgtac gcgtggccgt caacctcgcc aaggaaccgg
     2641 cggcgatccc gctgggtccg cgcaaggcgg ccgtactggc ggcgtgggag ccggtggagg
     2701 cgccgggggc ggacggggtg ctggaggtgc ccggggagtc gggggtggtg ttgttgcagg
     2761 ggtgacgaga gcaagcgacc tcacagggcg atgggctctc agatcccctc cccgtcctag
     2821 tcctccctca gctccgtgac ccgctccaac aggatcgcct cccacgcatg cccaaggcgt
     2881 tgcctcagca gcggcagcgg cgtctccccc gtgccgtcga gccgggccgc gaggtcgagc
     2941 accgcgtcgc agcgggccag ccacaggccg cgcaggcagg ggcgggcgcc gtagccggcg
     3001 agggtggcgg cgcggacggc ggccggggag cccacggcga gcgcgagacc ggcgatgtcc
     3061 tccgccgggt cgccgaggac ggtgtcggcc cagccgagga tgccgcgcac ccggccgtcg
     3121 gcgctgacga cgaggtggtc ggcggtgagg gcgtggtgga cgaggacggc ggtgccgggc
     3181 tgggcggcga gctggacggc acccggctgg gtcagctggc gcagccgggt cgcgtcgaac
     3241 tcgtcggcgt cggcgaggcg cgcggccggg cgttcggcgg cgcggcgcag ggcctccagg
     3301 gagcgtggcg cggtgcgcgg cacaccgagc gcctcggcct gccgtacggg gacctcgcgc
     3361 agccccgtga gcagcccggc cagatcggcc tcgccgaccg ccgagacgtc gtaccgggtg
     3421 cccgaaccgc cgggcacctt gctgtcgagg gtgtaggtca gcccgggcgc ccactcgccg
     3481 tacgccacgc tcgtcggcag cgcgacgggg acgtgcgggc ggaccaggtc gcgcaggcgc
     3541 agctcgcggc gctggcgggc ggtggcctcg cggtcggggg cgaggcgcag cacatgccgg
     3601 gtgccgaccc accaggtggc gggctgggcg ccgggggccg cggggcggac ctcggggccc
     3661 gccgagtcgt ccacgccgtc cttgagcagg gaacggacca gtcggcggac ggtgtccgcg
     3721 gtgggtgtcg gtgcctgggt catggtcgcg ccgctgtcgc tcgggggtct acgggggctc
     3781 cttgcgccgg gatcggtcgg ccgctcagtc gactatgacc agctcgcggg tcgtgtcgtt
     3841 gaggcgccgg ccgccgtcct cggtgacggt gacgatgtcc tcgatgcgca ctccgaagcg
     3901 gccgggcaga tagacgccgg gctccacgga gaagcacatg ccgggcacca ggggctgctc
     3961 ctcgccctcg atcatgtagg gcggctcgtg ggtggtgacg ccgatgccgt gcccggtgcg
     4021 gtggatgaag tactccccgt agccggcgtc cgcgatgacc gcgcgggcgg cccggtcgac
     4081 ctcctggcag gcgacgccgg gccggaccgc tcggaagccc gcctcctggg cctcgcgcac
     4141 caggtcgtgg acccggcgct cctcgtcggt gggttcgccg acgtggacgg tgcgggaggt
     4201 gtcggagccg tagccgtcct tcagaccgcc gaagtcgagg accaccatgt cgccgcgttc
     4261 gatcgcgcgg tcgcccacct catggtgcgg gttggcgccg ttgggcccgg aggcgacgat
     4321 ggtgaagtcg acctgggagt gaccgaagcg gcgcagcaga tgggcgaggt cggcggcgac
     4381 ctcggactca cggcgaccgc cgaagggaac cttccggatc tcctcgaacg ttgcgtcagc
     4441 ggccgctccc gcggccgcca acagctccag ctcggcggcg tccttgacgg cgcgcagcat
     4501 cggcagggcg tcggtgaggg aggcgtacga ggtgccgggc agcgcccgct gcagggccag
     4561 cagatgcatc gcccaggcgt tgtcgctgat gccgaaccgg ccgctcgggt cgaggagggc
     4621 ggcggtggcg gcgtaagggt ccttgccgtc ggtccagtcg cgcaggttca gaccgggcgc
     4681 gccggaggcc ttcgcggcgt ccggggcctc cagggcgggg acgatcagga tgggatcccg
     4741 gccggggacg aggaccagca gggtgagccg ctcggtctcg gcggtgggcg cgtagccggt
     4801 gagccacacc aggtcggggc cgggtgccac caggagcccg gccagccccg cgtcggcggc
     4861 cgcccgcgcg gcacgctcca tacgggcccg gtagtcgtcg gcggtgaagg gcgcgggtgc
     4921 ggtgccggtc atccgggcct ccctgggcgc gtgaagggac tacgggcagc atcctgcccg
     4981 ccctgagggg gcggcgcgag ccgatcggcg ggtctggcgg gcggccgctg gggcacggct
     5041 cagccctcca gtgccatacg gacgccgagg aggagcagta cgcccccgga gacctgttcc
     5101 aggcgtctgc gcacgcccgc gcgggacagc accgacctca gccggccgac gaaccacacg
     5161 tacaggccgt agtagccgac ctcgtagacc gcccacagcg cggcgaggcc gatcatcgtc
     5221 ggcaggtgcg gggcgccctg cgggacgaac tgcggcagga aggacatggc gaacacggcc
     5281 gccttggggt tggcgaggtt gagcagcagt ccgccccggt aggaggccca gccgctcttc
     5341 ggtgtgctct cccaggtggt ctccccggcg ccgttggcgc ggcgggcctg gcgcagggcc
     5401 tggacgccga agccgacgag gacgaccgcg ccgacgacgc ggatcacgtc gtacgccatc
     5461 tcggaggccg tcagcagcgc ggtcaggccg aacgcggcga ccaggcccca gatgaagaca
     5521 cccgtctcgt tgcccagcac ggtcaggaag cccgagcgcc tgctctgcag cgactgcttg
     5581 atgatcagca cggtgctcgg gccgggtgag gcggcgacga gggtgcaggc tccgaggaag
     5641 gcgatgaggg tggtcggcat gggggtcatc gtggccctgt cggcggaacg tgaccagtgg
     5701 ttttcacgga ctcgtccaac gggcccggcc gacggtctcc gccggcggcc tcgtccggcg
     5761 gccgggctca ggtgacgacg cccgggacca ccgtcagctg ctgatagccg ccgctgcggt
     5821 ggcgcacggt caggttgatg ccgtcgcccg ggcgggacct ggcgacggct cgtgcgaggt
     5881 cggcggccga gtcgatacgg gtccggccga aggcgaggag caggtcgccg cggaccagac
     5941 cggcggtgta ccccggtcct ggcacatgga cgccgacgat cagggccccc ggcccgtcgt
     6001 cgtccacggc ctccacaccg agggtggcga cgacggccgg ggacggcgag gagaccggag
     6061 ccggggagtg cgaaggtgtt gccgggtttc cgggtgcccg gtgcccggcc tgccgctgca
     6121 gctcggcgag tcggctcatg ccgatcaccg tggcacccac ggtgccgagt ccgaccccgg
     6181 acagaagcag gaccagtcct gccagcaggg cgcaccacag ggtcgtgagc cgtcggccac
     6241 ggcgccgggg cgcggcgtgc ggccgtcgtg cgccggggtc ggacgtggca ccttcgccgg
     6301 gcccctgacc aggcatgggc ttgggtcgca acgcagtctg ttccatcgga tcgcctccgg
     6361 ctggtgacta ccctgcgcac cggcgcacaa cgatccacga acgagtgaga ctgacccgtg
     6421 gtcaggggcg ggaagccata gccgtcacac gcgcgtcagc ctgtgtggcc gcccccgtgg
     6481 ccgccgtggc cgccgccgtg gtcgaacttc agggcctccg gcggcatgac gacgaacggc
     6541 cgcatcatgc ccatgtcctc gtgctcgagg aggtggcagt ggtacatgaa ccggccgtac
     6601 gcgccgtcga acctgcccat cacgcgcagc atctggttcc ccggcacccg gaagacgtcc
     6661 ttgtagcccc gctcgttggg cgccagcggg atcgtggtgc ccgcgtcgtg gcggatcggg
     6721 ccgcgggtgc cgccgatcgc ggggtcgaag ccggagacgt cataggcgtc ccggccgagc
     6781 agctggaagt cggccaggtg gatgtgcatg gggtggacga tcggcgcgag gttgaggaag
     6841 ctccactgtt catggctgcc ctcggcgatc gtgaagccca ggccgtcgtt gaaggtgcgg
     6901 gccgtgcgcc ggtaggtctt ggtcttcccg tccggtccgg tgacctggat gacgccctcg
     6961 gtggggacct ggatgtcggc gccttcgatc tccgtcatct cccagatctc cgggtggccg
     7021 ccgcctccct tggtggcggg cggggtgagg acgatcagcc ggtggccgtg ctcgatgtca
     7081 tgggtcagcc ggcggaagga gccggagagc acctcgggca gctcgaaggt gtccgcctcg
     7141 cacgtctccc ggacccggaa ctccatgacc gccggatagc gcacgtcacc ggccgggtcg
     7201 ggcacgccgg gcggctggtt ggcgcccttg ttcaccaggc ggagcgtccg gcccgcgagg
     7261 ccgcggaagt cgacgagcag atcgaaacgc tcggccggcg cggcggtcag ggtgggcagc
     7321 gcgccgtcga agtcgaccgg gaccgggcgc ggcagcagtc cgccgtcgct gccgatctgg
     7381 tggacgacgc ccgggaccgg gttgtcgtcc tcgtcgatca ggacgaggtc gtaggtgcgc
     7441 gcgttggacg cgttgaccag ccggaagcgg tgccaggcgg cgtccacgtc ggcgtacggc
     7501 cagatgcggc cgttgaccgt ggtgtacggc ccggtgaacg ggatggagac cggcttgccc
     7561 gtctccgggt tcttgtcctg gacgatcacc gtcttgtgca gcagcctgcc gttgagcctg
     7621 ccgtcctcgt cggtgtcgag attgcggtcg gcgagcagca gcgggatctc ccgctccccg
     7681 cggggcagat gcagggcgtc ctcctcgtcg tcacggacga ggtaggtgcc gtacaggccc
     7741 gtcatcacgt tccaccgcgt gatgttcatc gcgtggtcgt ggtaccacca ctgcaccgcc
     7801 tggtggtcgt tcggatactc ggacagctgg gcgtcgccga agcccaccgc gttgtcggcc
     7861 cagccgtcgt tgccaccgcc cgtctgggcg ccgtgcagat gggtgaccga ccaggcgggc
     7921 agggcggcga cgtccttgtt cggctcgacg ccctcgcggc cgggctcggt ggtggactgc
     7981 gggcggccgt cggtgcgcag tggcacctcc accgaggtga ccgggtactc gctgtccttc
     8041 gggatgcggt tggtccaggc gatgcgcacg cgctgtccgc gccgcacttc gatggtcggg
     8101 cccggcaccc ggccgtcgta tccccacatc agggtcggcg gcagctgcgg gtgcaggcgc
     8161 acccaggtcg ggcgcagggc gatctcggtc tcgcgcagga cgtcgccgga cgccgggcgt
     8221 aagacggtgg ggacgggcag cggggccacg tacggcgtga gctcgccggt gtggagcggc
     8281 tgctccgtct cggccttcgc gtcgctgtcc gtgaacctct cgatgatgtc ggtcaaggtc
     8341 gaacaccccc gtgtgttctc gttgtctgtt cccctcacct cagaagactc gcgacgcacc
     8401 ggggaagttc cctgaatatc ccattccgca cgaaaagttt cggaaacggc atccggaggc
     8461 gggaagtccg ttgtcagtgg ccgctgttac gttctgtgac atgaccgatc gcgcgctgcg
     8521 gctgctccgg cagcaccaac atctggccga actggccgcg ttccccttca acttcgacct
     8581 ggcccgcgcg gcccacggcc atgtcgagga ggtccgcctc gcctcgggtg ggccgctgga
     8641 ggtggtggcc ggggacgaca ccggcggtac gtatttcgtg tgcgcggacg ggtcggtgct
     8701 ccacgccgac tcggagggct cggccgggat catcggctcc agcgtcgccg aggccctgga
     8761 gatcatgatc ggtctggcgg aggtcgagga cgaggacgac gaggagggat ccgatgggcg
     8821 ggatgaactc gagcaggcgc gggcggagct gcgtgccgcg ttcggctttc cgcagcgctc
     8881 cgtcgcggag ctcgaagcca tgctccgggc cgcgctcctg cgcaccgaac ccgacttcgt
     8941 cctgctgaac gacctggagc acaacgccta tcaactgctc gacacctacc cccgcccgcc
     9001 tctgtgggag ccggttctcg cgaccggtcg cgccgatctg gcgatgctgc gttcgggcgg
     9061 gcgcacggcg tgggaggagg tggccgagga tgccctacga cgccgactcg ccctgcgggc
     9121 cgcgcagttc gaccgtgccg agggcgatct ggagctgctg cggcatctgc tgcggcagga
     9181 ggcgcggtcg tcgatgacgg aggaactgcg gctggccgcc gtactggtgg ggctgcacgg
     9241 tgacccggcg gacctgtcgc tgctgcacga ggtgcgggag acggacttcg acaccgcgtg
     9301 cggcctcggc gggatgccgg aacccggggc gagctcggag gagttgcggg actgggcggt
     9361 cgagctcgac gagtcgctgt tcggcacgga cccctcggac gagccggtga gtacctggac
     9421 cgacctcgcc cgggaccagg gcatgaccga gctggcccgg gtgacgctga tccgggaact
     9481 cgacgagatc ttcatggacc agagcagact ccgccgcccc gacgccccac gcgcgttggc
     9541 caccgccccg ctgcgcgcgc tcgcccgtga cttcgaggaa ctcggcgatc tgccccaggc
     9601 gctgcgcgcc cagaggctgt acgccgccct tcaggagacg gcatgggacc gggcctcggc
     9661 gctgcacacc caggcccttc tggaacggga gtcgggccaa ctgtcagagg cgacagggac
     9721 cttggccgcc gttcgggacg ccctggccac ccctggagac gactcgctgc gccactggca
     9781 gagcgtgaac ctcggccgct tcctcaccga ggagcactac cggctcaccc gcgccctggc
     9841 cgacgcgaac cggccggagg acgcccgcgc gctcctcgcg gcggccgacg cgatactcgg
     9901 cgagctctcg gagaacgccg cgaacggcat acgggagctc gccgaggaga ccgcggcacg
     9961 ggtgcgcgag gtcggctgag gacgggcggg cgccgggggg tcagccgagg accgggaccg
    10021 cgggagcgcg gtcgggcagg aagccgtggg cgcggcgggc caggtactcg gccttgtagc
    10081 gggggacggt ccggtgccag ttcaggatgc ccgccatcca gttctggagg tcgacgacat
    10141 agttctccat gatctcccgg gcctcttccg agaggccgaa gtcctcgtac acgatgggca
    10201 gttcatgcgc ggccacatgc tcgaactgct gcatgcgctg tgtcatcaga tcgtggacga
    10261 catggagcgc ggtcgggtag tcgacgccga agaagttctg cacgacgagg atcgagttgt
    10321 ggatctcgcc ctcgtactcg atctccttct ggtaggagaa gacgtcgttg aggaggcagg
    10381 cgtagtcgac ggcggcgttc tccagtgagc ggacggggcc gctgcggtac acctccgacg
    10441 gtacggcggg gccgtggccc attcggcaca ggctgagggt gaggtcggcg ccgaaggtgg
    10501 cgcggcgcat ctccaggtag tcgaccgggt cggggatgcg gttctggagc tggttggaca
    10561 gctcccacac ccagctctcg gtcatgacgt ccaccgagtc cttcacggcg cgccgttcgt
    10621 cggcggtcat gccggcggtg gtgtgcgccc acaggtcgat caggccgcgt tccatgccgt
    10681 tggccgggac gatcggcggc tcgccgtcga ggggcatgca gtccgagagg cgctgggtgg
    10741 tgagccgggc ggcggccagg tcgcggcggt ggccgaagac gagagggtag tagtcgtcgc
    10801 cgtaggtgcc ccaggcgagc caccgggcgc tgaggtcgag ggcctcgggg gtgccgtcgg
    10861 ggtcgaggcc cgccgagcac agcgcgaggt cgtaggcggc gagtttgtcc tcgtcccaga
    10921 cgccctcctg gagcatgccc atgcggtgca tccagtcggt caggcgcacc cgcgtggcgg
    10981 cgaggtgcgg gctgagctcg cactggtacg gcatgtggaa gtcgggcagc agggaggggc
    11041 cgaccttctg gaacggcaca tgggtgtacg cccgcaggcg ttcggcgccg gccgaggcga
    11101 ggagtgcgcc cacgtcggcg gcggaggtgc cgggtccggt caggccgcgc cagggtgtgg
    11161 tcggctcggc gcgtgcgttc atatagcggc tggagcgcat gtgccattcg tggccgccgg
    11221 actgccagtc ctggagcccc tgggcgtacg aggcgacggc ggcgacctcc gcgggggtga
    11281 gtccgtgctc cagtgccacg gccgggactt cggtgagggc ggtgtgctcg aactggtgga
    11341 ggcgggaggt gaggacgtcg ttgaccaggt cggcggcctg ctgggtggtg cagtcgaaga
    11401 aggtctccag caccaggacg ccgttgctga gttcgccctc gtcctcgacc tcgcgctggt
    11461 aggagaacag gtcgttgcgc aggtgcacgg cgtcggagaa cgtctccatc agcaccctga
    11521 gcggcctgga ctcggcgacg gacgcgggga cttcggcggt cgcgtactcc acgaggcccg
    11581 aggaccaggg ggcgccgccg accttgcggc gcatctcgat gtactcgacg gggttggcga
    11641 tacgcccctc gttgatgttg gacagctccc acagggactc gttgaggagg tgctcggtcg
    11701 ccacggagaa gcggcggtgc cagtcggcgg acatcgtggg caccgtgcgc gtccacaggt
    11761 cggcgaggcc cgcctcgacc ggattctgcg gctccggcat cggggccgag aggtccatcg
    11821 gcatgaacag gggcagccgg tcgaggtagg ccttgccgcc ggcgcggtcc tgggtgcgct
    11881 tgaaggtctc caggaagtgg tcgtcgaaga agaagaccca cacgtaccag tcggtgatga
    11941 gggagagggc ggggccgtcg cactcgggat gggtgtaggc gcagagcagg ccgtagtcat
    12001 gcgcttccag gtcggcctgc tcccagatcc cggacccctc cagcatgccc atctcgcgcg
    12061 cccactcggt cgaatgggcg cgggcctcgt cgacatgtgg gttcagccgc gcgggatacg
    12121 gcatgtagaa gtgcgggagt tcgaagggct gctgcgtcat ggccgggccc tacccctggg
    12181 ctccgggagg catccgcggc gcgggacatg atcacaccat cgcgtgaatc gcgggtgaag
    12241 tcgggagttc tcggcgggcc ttgtggcgtt catctctacg cgcgcagact tttcgagcct
    12301 caagtgaatc cccctttgtc ccctcccgca ccggagtcgc gatgaccccc accggatccc
    12361 tctcccgccg tacggcactg gcctccctcg ccggggcggc gctggccacg accgcggcgc
    12421 tccctgcctc ggcttccgag cggcatggcc gccggtccgt ccggttcgcc accttcaacg
    12481 cctccctgaa ccgcggcacc cagggcgcgc tgatcaccga cctgtccacg ccggacaacg
    12541 tccaggcgcg caatgtcgcc gagaccatcc agcgggtcga cccggacgtc ctgctgatca
    12601 acgagttcga ctacgacgag cagggcagcg cggtccggct gttcctgcgc aactacctgg
    12661 ccgtggggca gcgcggtgcc gcgccggtcc gtttcccgta ccactacacc ggtcccgtga
    12721 acacgggcgt cgccaccggt gtcgacctcg acgggaagaa cggcgcggtc accacgcccg
    12781 ggtcggacgc gtacggccag gacgcatacg ggtacggctg gttcccgggg cagtacggca
    12841 tggtcgtgct gtcgaagttc ccgatcgaca cgcgcgcggt gcgcaccttc cagcgcttcc
    12901 tgtggaagga catgccgggc aacatcatgc cgcccggcta ctacagcgac gaggcccgcg
    12961 cgatcctgcg cctgtcctcc aagagccact gggacgtgcc ggtgtgcatc gggcacgaca
    13021 ccgtgcactt cctcgtctcg cacccgacgc cgcccacctt cgacggcacc gaggaccgga
    13081 acgggcggcg caaccacgat gagatccggc tgtgggccga ctatgtcggt gggcgtcggc
    13141 gcggttccta tctgtacgac gacaaggggc ggcggggtgg gctgcgggtg ggggcgcggt
    13201 tcgtgatcgc gggtgacaac aatgccgatc cgtacgacgg ggacagctac gaccacgcga
    13261 ttctgcagtt gctggaccac cctgcgatga accttcccgc tgtgccgccg gccagtgcgg
    13321 ggggtgtgga ggccgcgcgg gtccaagggg gcgccaatgc ggcgcatcgc ggtgatccgg
    13381 cgtatgacac ctccgacttc ggggacaccg cgccggggaa tctgcgggtc gactatgtgc
    13441 tgccgtccaa ggggctggtg ccggggggca acggggtctt ctggccgacg tccgacgatc
    13501 cgttgtatcg gctggtgggg gatggggtga gtgtgccgac ttctgaccat cggatggttt
    13561 ggcaggacgt gcgggtgggg tgagtcgggg agggggcggc ggccggtggg cggggcgtgt
    13621 ttcgcccccg ccgcccctac ccgtcccatc ctcgagaggc tccgcccctt cgaccccagg
    13681 ccctctctgg gggctgcgcc cccagacccc cgctgccggc cctatctctt gcggaccgcc
    13741 ctgcccacct ccgacctcaa ggtcacgaac tccgtcaggc cgcgggtcgt gatctggtcc
    13801 cgggtgtcgg ggagttcgac cgggaggtcg aggacgatct tggcggcggg gcccggggag
    13861 aggactacga ctcggtcgcc caggtagacg ctctcgtcga tgtcgtgggt gacgaagacg
    13921 atggtcgcgc cgtcggtgcg gtggacctcc agcaggaggt cctccaagtc ctctcgggtc
    13981 tgggcgtcga gggagccgaa gggttcgtcc atgaggagga gggaggggcg gcagaccagg
    14041 gcgcgggcga tggccacgcg ctgctgcatg ccgcccgaca gctgccaggg gtggcggcgg
    14101 gccgtgtcgg tgaggcctac tcgggccagg atgcggtcgg cctcggcccg gcgttcgttt
    14161 ctcggcaggc ctctgcggcg cagtgggagg gccacgttct cgcggaccgt gagccagggg
    14221 tagagggagc gggcgtagtc ctggaagacc acggccaggt tgtcggggac gccgcgcaca
    14281 ggagtgccgt ccagggtgat cgtcccgtcg tacgtcggca gcaggcccgc gacggtgcgc
    14341 agcagtgtgg acttgccgca gccggacggg cccacgacac acaggagttg gccgtccggc
    14401 acggtgaggg tgatgtcgtg caggacctgg tggtcgccgt agtgctggcc gacctcgtct
    14461 aggcggagca tggctgtccc tgggcggagg tgataggggg cgtacgggtc atacggtcgt
    14521 cgtcctcccc ttgccgatca gtcgcttctc gaccgccagc aggccggtgt tgaggaggta
    14581 gccgagtgcg ccgagcagga ccagtgccga ccagacggtc agcaggtcgg agcgggactg
    14641 ggcgtcggtg agggtgaagc cgatgccgtt ggcggtgccg gggaggagtt ccgagaacac
    14701 catgaggatg agggagaggg agaggctcag ccgcaggccc gcgaagatgc ggggcagcgc
    14761 ggagggcagg atcaggaagc ggagccgttc gacgggggtg aggcgcagca cggcggcgac
    14821 ctcgatgcgc aaggggtccg tgtcacgggc gccctcggcc gtgttgatca gcaccggcca
    14881 gatcgcactg aagacgatcg acgcgatctg catcggcgta ccgaagtcca ggatcacgac
    14941 gaacacgggg accagagcgg gcggcgggac ggcgcgagcg aactgcagaa ccgggtcgca
    15001 caaggcgtac acgcgtcgcg agcggccgat cgcgacgccg agcgcgatcc cggcgacggc
    15061 ggcgatcccg aacccggcgg ccatccggcc gaggctcggc aatatgtctc cgaccgccgc
    15121 ctccgtgagg aacacatgcc gcgcgggccc cgagaaccag agatcgagcg cgtgccccgc
    15181 gatctcgacg ggcggcggga agtacacgct gccatgagcc ccggcgacca actgccagac
    15241 caccacggcg agcacaagca ccgtccagcg gagcagggcg tggcgcacgg ccaaccggcc
    15301 cgcaccaccg gcaccagccg cacgacctac acgacccgca ccacccatac gcgccccaag
    15361 accgaccccc ctcaccccac cctcacccaa ccccccgccg ccccggcgtc cacggaaaca
    15421 gcctccgctc gccccacacc aacaccccgt tgatgaccag ccccagaccc cccgcccaca
    15481 ccacccccgc cagcacatcg cgtgtgccgt ccgtggccag gcccgcctgg gcgatgaaga
    15541 tgccgaggcc ctcgccgaag ccggagagga tctccgtggc gacggcgagg atgagggcga
    15601 ccgcggccga gatgcggatg ccggcggcga tgaagggggc cgtgcccggg agttcgaccc
    15661 ggagcaggac accgacgcgg ccgaagccga aggcacggag ggtgtccttg gccagggggt
    15721 ccgtctcggc gaggccgtag atggtgttga agagaatcgg ccagaccgac gcgtacgtca
    15781 ccagcgcgac cttggtctcc gtgcccgagc cgagcagcag cgagaccagg gggatcagcg
    15841 cgacggacgg cagcggccgc aggaactcca cgatcgcgcg tacggcggcg tcgacgaccg
    15901 gcacgctccc gaggaccagg ccgaccggga cggcgatccc gatggcgagg gcgaggccga
    15961 gcgcccaggc ccgcaacgtg gcggcgatgc cgtccaggaa gacggagtcg cccgccagtt
    16021 ccacggcccg cgcgaggact tccgaggccg gcgggagata gctgcgccgt acgagcccgg
    16081 agcgggagac ggcttcgcag gccccgacgg ccagcagtac ccccagacca cccagaagga
    16141 attgttcctg acgggccttc acgtcacttg accagcaacg tcgccggatc gatcggcttc
    16201 ttcagcatcc cctgcttctt catgaggtcg gtgagccggg tgagctgcgc ggcgtccatg
    16261 gcgggcggga agacgggcag gtcgatggac ctggcctgct cctcggtcac cttggtgtac
    16321 gtcggcaggg tgtcccgcac gacggacgga tccttctcgg cgatctccac ggccgccttg
    16381 atggcccgct ggaacgcggc cagcgtcctg ccgtgtccgt cggcgtaggc acccgtgctg
    16441 atgtagccgc tcagcggaat ggcttccacg ggggccgacg agccgtcgac gaggaccctg
    16501 gcgttcagct cgtcctggat ggcgctgtcg tagggctcga ccgcgtgcac ggcgtcgacc
    16561 tgccccttgt cgagggcggc gcccatctgc gggaagggaa tcgcccggta gaccggcttg
    16621 cccacgccct gtttctccac gatctcgtcg aaggtcagcg actggacgtt gttcaggacg
    16681 ttgaccgcga gcttcttccc cgcgagatcg gcgacgctct tgatgtccga gtcctcgggc
    16741 accagcacct ccatcatgcg cggcgccgcc ctgatcgcct cggcgacgat ccggatgtcg
    16801 agggtgccct tctcatgggc ctggagatag gtcacgtagt tcgcgctggc gaccatgtcg
    16861 atctggccct tggccagtgc gggcagcgcc tggaggctct gctggatctg ctggatacgg
    16921 acgtcgagcc cctccttctc gaacaggccc cgctcctgcg cgatatagag ggcggcgcag
    16981 tcgatcaaag gcagggccgc caccctgacg gtctcccgcc cgccggcccc ggacgaggag
    17041 tccccgtcgc cgccgcaggc cgtgaccgcc accaatatga gggtggccgc ggcggccctc
    17101 gttcccgagc gcaattgacg taagggcatg acgtcatgac tagcaagaat ttgtcatgat
    17161 caccacatac ggcgatacgg agatgtgtcg acctgtcgat ctccaccgac ttacgccacc
    17221 ttggtcacat ggcttcctcc cccgtccccg atacccctgc ccccgactcg ccagctctcg
    17281 atacccccgc ccccgatgtc ttcgaccccc gccaatacgc caccggcgtg ccctaccccg
    17341 cctaccgcat cctgcgcgac caccaccccg tcgcccggca ggacgagtac gaggtgctgg
    17401 gctggcccgc cgggcccggg ttctgggcgg tgacgcggca cgcggacgtg gtgcgggtgc
    17461 tcaaggactc ggcgacgtac tcctcgcgtc tcggcgcgac acagatccgc gatcccgatc
    17521 cggaggacct gccgttcatc cggcgcatga tgctcaacca ggatccgccg gggcacggac
    17581 gattgaggcg gctggtcagc cgggccttca ctcccggacg cgtggaccgt ttcgtcgggg
    17641 tcgcggagga gcgggcgcgc tcactcctgg cgcaggccct cgacacggcc cgcgccacgg
    17701 acggcaccgt ggacctggtc accgccgtga ccgacgacta cgcactgctc aatctcgccg
    17761 acctgctggg cgtgccggag gccgaccgcg ggctgctcct gcactggacg cagcgggtca
    17821 tcggctacca ggatcctgac gaggccggtc cccaggtgct ggacggggag ggcaggccgg
    17881 tcaatccgcg gtcgcccgcg atgctgcggg acatgttcgc ctacgcccgc caactggccg
    17941 cacacaaacg gcggttcccg gccgacgacg tgatgaccac tctcgccaac gatcccgaac
    18001 tcgacggacc cgaactggag atgttcttct tcctgctcac cgtcgccggc aacgacaccg
    18061 tccgcagcgc ggcgccgggc gggctgctgg cactcgccga gcacccgaag tcgtacgagc
    18121 gactgaggac ccgtgacgtc gaactacccg ccgccgtcga tgagttgctg cgctggcacc
    18181 ccccggtcct caccttccga cgcaccgcca cgcgagacgc ggaactcgcg gggcaacgca
    18241 tccgcgccgg tgacaaggtg gtcgtcttcc acgcctccgc caaccgcgac gagcgcgtct
    18301 tcgccgaccc ggaccggctg gacctgtccc gcagccccaa tccgcatgtg tccttcggcg
    18361 acggcccgca cgtctgcctg ggcgcgcact tcgcacggct tcagctgcgc gtgctctatc
    18421 gggagaccgt ccgggcggcg cccgtactgc ggaaggcggg cgagccgaag cggctggtgt
    18481 cgaacttcat caacggcatc aagtccttgc cgatgcacgt cacttgagcc gagcgacgac
    18541 cgggcccgcc gcccgagcgg tcacccccgt acctgaatca gcgcatgcgt cccgccggtg
    18601 cgccacttct ggccctccgc cgccaccagc gccgcctccg tacgggcgtc caggccggtg
    18661 atcacgtcgg acttgagggt acgcagggcg gcgaccgagc cggggaagta ggcggtgacg
    18721 tcgaggaagg gcgtggtggg cggccagagc cggtcgccga ccagacggcg gtagttgagg
    18781 tcgcccttga ggacggtgag ggtggcggtg gcgagttccc cgcgcaggtc ggcgggcatc
    18841 tcggcgtacg gcagcggggc gctggagaag gggtgcgcgc ggacggcgag gcggccgtcc
    18901 gtgatcgccg accagagggt acggccgtag tccgcggcgg cgccgggtgc ggacgtcagc
    18961 cggcgcaggg cgtcgagcac atcggcgtgc gtggcgtcgg agacgtagta ggggtacggc
    19021 ttgatgtgca ggacggcccg gccgatccgc ccctgggtga ggagatgggc gatgaggagc
    19081 aggtcgggga tgagttcgcg gcccgcgttg tcggcgatca ggcagagggt ggcggtgccg
    19141 gagggcggga gcagggacca gagggtctcg ctgtcatcgg acaccagggg cggggtgtcc
    19201 gaggcggtgg cggcctgcgc ggcggacagc cggaagccga ggtccgcgcg attgccccac
    19261 agcgaaccgt gcagcagggc ccggtcctgt tcgtcggtgg gccgctcggc gagggggtcg
    19321 agggcggcca gttcctcgtc cgtctccggg gcgttcagtt cggccagttt ggaggggcgg
    19381 aaggggtcga tgcccagcca ggggccgggg gtgaagtagc cgacggcttc gaggagttgg
    19441 cggtagaaga agctctccga ccacagccac ggtacgtcga accaggagcg gccggtgtac
    19501 gcctcggcgc cccacgcggc ccagcggtcc cggtcgtgcg cgtcggcggg gagcggttcg
    19561 atcacgcctt tggtgcagct cgcgaggagc gcgtccaggg cgcggtgccg ctcggggtcg
    19621 tacgggaagg agtcccgcac ctggctgatg atcgcgggat gccgttcggc gagcacgctg
    19681 tgcgggaacg agccgggttc gttcccgagg agcacggacg cgggcggggt gtcggacctc
    19741 tcgggcatgc ggctcacggt accgcccgtg tcatggggct catacggtct tgatctcccg
    19801 ctccagctgt gtcgccagcg cgagatagcg ggcccggcgg ggcaccggga ccaggccgcg
    19861 gatcatgagg tgccacatct cggccactct gcggggctgg cgtgcgacgg gttcgaggga
    19921 gcggccgacg acccgggtgc cgacgaagaa gcagaccagg gcgtgggccg cggcctcggt
    19981 gtcgacgtcc gggtggatgt cggcttccct ggcggcgccg tggagtctgc gggtggcgat
    20041 gtcaagcagt tcgttgaagg ggtgccgcag cggcggccgt atcaccactc ccccggtcgc
    20101 caggcgcagg ccggcccggg tgatcgggcc ctcgacggcg aggcgggtga tgccgaacgt
    20161 cgtgcgtatc agcgcctcca gcgaggtgtg gccgcgggcc tccatctcac cggccacctg
    20221 ccgggacgcc ctggactgga gctccatgat cgcctgcgcc agatcctcct tggccgcgaa
    20281 gtggaagtac agcgcgccct tggtgacctg ggcgtgttcg acgatgtcgc tcaggctcgt
    20341 cgattcatag ccgtgacggt cgaacagctc ggctgcggcc gtgaggatcg tggtgcgggt
    20401 ctgttccgcg cgtaactgcc tcgccatcgg ctggactctc ctgggctacg ggaaaagaac
    20461 gggtcatgcc gtttgtttct tactccccgt acacgatagc tcacccgtcc acggtgccca
    20521 cctcgcactc gaagaccgtc gacttcccct gccgccccag gacttgtacg tcggatccgt
    20581 cgccgccgtt cgcctcttcc ttgccggcgg tctctatcca tgcgggcagg tcgagttcgg
    20641 cgtaccggtg gaagacggca cggaacgagg cgggtgtgcg ccggccgctc cccgggcggg
    20701 cccgcaccgc ctggcgggcg gcctccagca ggagcattcc gggcacatgg tcgagtgggt
    20761 ggtcgaagaa aacagcatgg gcggtatcga ctcgcaactg ccagcggtcg gttcggccgg
    20821 tcggggcgag gacgacgtcc ccgggcaggg cgcggtccac gacggcgggg gccagcccgc
    20881 gcgggaccgg cagcgcggac acggtcgtgg cgttgcggcc accgcgaagt cggcggtaga
    20941 cggccgcact tgtccaggca acggccacct gcgcggtcgc gacgcgttcg tcgtcgagga
    21001 gtacgtcggt gtcgtagcgg aatccggcgg ggcggccgcc gcggtgctcg acatcggtga
    21061 cggtgatccg gagaaccggt gcagcggggg cggggcccag ggccaaccgc tcgggacgcg
    21121 tggcgatccg cagttcccgg aggacgaact ggtggcccag cgggacgtcg taggcggtgt
    21181 gcgcgagcaa tgcgccggcc tggcgggcgg tttccgcgac cagcaggggt tcatacgccg
    21241 accggtcggg cgacacgtgt aactggtggg cacgcggcca ctccgcgaag accgtgaacc
    21301 ggtcggtgtc gatgctggtc accccggtga gaaacgtttc cgccagcgag gcgcggtgca
    21361 cgagttggcg cggtacggtg gccgtcaggc cgtgcggcgc ctcgggggtc gcggcgagcg
    21421 gggccgtgct gaggtggcgc ggatgagaca tgtcccctcc atgggtcccc cgtatgtgcg
    21481 cgcttgacat acggcgaggt gcccgtgccg cgagcgttag agtacgagcc gaccggtttg
    21541 ttttcaatgc ggcctggggt cgcccggccc tgcccgaact gctccggcgt acgccgagcg
    21601 cgcaggtctc gactcggcgc ggccggaaac atacggaggg ctgtcatggc gaggcaggag
    21661 cgcgccatca gaacgcggag ggtgatcctg gaggccgcgg gcgcggtctt cgacgagcac
    21721 ggttacaccg cgacgaccat ctcgatggtg ctggagcggg ccgaggtgac caagggcgcc
    21781 ctgtatttcc atttcccctc gaaggaatcc ctcgcccagg ccgtgctgga cgtgcagatc
    21841 ccgctgggcg cggtgccgcc acagccgtgc aagctccagg aactcgtcga cgtcaccttc
    21901 gtgttcggcc gacggctgct gcacaactcg ctcctgaagg gcagtgtgcg gctggcggtg
    21961 gaccagtgcg cgccgcccgg tgtcgaccac tccggtccgt tccgacagtg ggccgaccat
    22021 ctggtggtcg tcctcgaaca ggcccgggac cagggcgagt tgctgcccac ggtggagccg
    22081 cggcagacgg tcgagctgct ggtcggcgcc ttcgccggcg ttcagctgat gtcgcgggcg
    22141 ctgaccgacc gggccgatct ggcggagcgg atctcggtcc tgtgggggca tctgctgccg
    22201 agcatcgcgg taccgggggt gctgaccggc atcgaccgcg atcccgaccg ggggctgcgg
    22261 gtgctggcgg cgatcggtga gagcgacgac gagcaggcgg acctggacct gttctgtcgc
    22321 tgagcgtttc gcgcacagac cggagtggcg gtttccaagg cctgtttcca gcccttcgcg
    22381 gcatacacac gacgggccgg ccgatgcccc atccgcatcg gccggcccgc ccgtttgtgg
    22441 tacgcgcccg ctgggggcgc gcgttcagaa ggtcagcttc cagctgttga gccggcccgt
    22501 gtcctgggcc gcggtgtcct ggacgcgcag cttccaggtg ccgttggcga tctcgccgga
    22561 ggcgttgacc gtgtaggtgg tgctgatgtt gtccgcggag tccgaggagc tggcggactt
    22621 cagccggtag gtcgttccat ccggcgcgac caggtcgacg accaggtcac cgcggtaggt
    22681 gtgggtgatg tccacgccta cctggagggc cgagggggcg ttgccgctgc ggccgctgac
    22741 ggtgatcggg gactcgatgg cggagccgtt gtccgggatg gagaccgcgg aggtgctggt
    22801 gaaggtggtg ccccccgtgg agccgccgga gccgccgctc accgcctgca ccgtcttggc
    22861 cgcgtccgcg agtcccgcac cgcagccgcc cgagcaagtg ccgggaagag tacgcgagtt
    22921 ggtcttgatc gcggactcga tctgggccgg ggtcagcgag gtgttcgccg acttcatcag
    22981 cgcggccagg cccgcgatgt gcggggcggc catgctggtg ccctggtagt actggtagct
    23041 ctcggacgag gggccctggc cgccggagtt cagcgtggac aggatgccgt tggacgtgac
    23101 cgagttggtc tcaccgccgg gagcggcgat gtcgacgatc gagccgtagt tggagtagta
    23161 ggagcggttc ccctggcggt cggcggccgc cacgctgacg acgttgccgc agctggccgg
    23221 cgagtagttc gccgcgttgt cgttgctgtt gcccgccgcg acgacgaccg tggtgccgcg
    23281 gttcactgcg gcgttgatgg cgctctgggt cgcggtggag caggcaccgc cgccgcccag
    23341 gctcatgttg atgaccttgg cgacattggc gttcgccggg acaccggaga cggtgccgcc
    23401 ggacgcccag gtgatggcgt cgatgatgtc ggagtcgtag ccaccgcact tgccgagcac
    23461 ccgcaccggg gagaccttcg caccgtgcgc gatgcccgcg acgcccttgc cgttgttggt
    23521 gacggcggcg atggtgccgg cgacgtgcgt gccgtgccag gaggaagtgg tggcgggggc
    23581 gccggcctgg cactcgttcg cggcggtcca gtcgcccggg tcggccgggt tgctgtcacg
    23641 gccgttgccg tcgttgccga ccgtcgcgtc ggagatgaag tcatagcccg cgacgatgtt
    23701 ggcgccgagg tcggagtggg tgacatagcc ggtgtcgatg acggcgacgg tcaccccgct
    23761 gccggtggcg acgtcccagg cgcccggcac gttcatgccc gcggtgctct cgaacaggtc
    23821 ccactgcttg ctgtactcgg tgtcgttggg cgtggccagc ggcttgttca gccggtccgg
    23881 tacgacatag gcgacctgcg ggtcggcctg gtactcggcg acgacgtcgg cgacgtccgc
    23941 cctggtgagg ttcgcgccca ggtcgacgag ggcggcgccg gagccgaggc ggcgctggaa
    24001 gtcgaggttc tcgccggcct ccccgccctt ggcggcggcg tcggcctcgg cggccttgtt
    24061 cgacttggcc tcggcggcgc cggacttgta gccgacgatg aggcgctcgg ccggggtgcc
    24121 gggcgcggcc tcggcctggg ccacggggac ggccgcttcc ggggcagggg aatcctgggc
    24181 gacggcggcc gtggtggtgg cggccgtgaa gagcgcggcg gagaccgcgg cgacggatat
    24241 cagcttccgt ctgagggagg ttgaggttcg caaggggagt gcctttcgtg gccggccgaa
    24301 ctccgggcag cgcggagcgg cggacgtttt cgcttcgtcc tcgaagcggc ggggggtgtt
    24361 tcgaaagtgc ggggtgcgga gtggggggcg ttgcgaccgg cctggcacga gcagcgaccc
    24421 gttcggggtt acctgtgggt cggctgtggt cgaacgatag gcaaagaaaa ggtcaccggg
    24481 atacagggga aaccctagat ccggccggaa acccaccctc tacgtcggcc gttcgaccgg
    24541 tatcgacggg ctctgcccgg ttcgtcgggc ggtgaacgcg ccgggcccgt cccccgtact
    24601 ggacgaggac ccttcccacg ccggccgagg agacgttccg gatgccccgg atgccctgga
    24661 tgagatcgca tcgctccgcc ctggcggccg ccgccgtcac gccgttgctg ctcacggtgt
    24721 gggcggcggt cccggcccgt gcgcatggcg ccccgacgga tccggtgagc cgggtgtacg
    24781 cctgctcgcc ggagggcggc agcgcgtcgg actcgacggc gtgccgggcg gccgtcgcgg
    24841 ccaacggcac ccccttcacg gcctgggaca atctgcggat cgcgaacgtg aacggccggg
    24901 accggcaggt cgtcccggac ggcaagctgt gcagcggcgg actgcccgcc taccgcggcc
    24961 tcgacctcgc ccgcgccgac tggccgtcga cccggctggc cccgggtgcg tccctgacca
    25021 tgcgctatgt ctcgacgatc ccgcacaccg gcacgttccg gctctatctc accaagcccg
    25081 gctacgaccc ggcgaagccg ctcacctggt ccgacctccc ggaccggccg ttcgcggagg
    25141 tgaaggaccc ggcgctgacg gacggggcgt accggctgac ggcgaagctc ccgtccgacc
    25201 gctcgggcag gcatgtgctg ttcacgatct ggcagaacag cagcacgccg gacacctact
    25261 actcgtgctc cgacgtggtg ttcccggacc gcgagagcgc cgggaaggag gccgacgggg
    25321 acgcggaccg cgacaacggc cgtacggccg cggcctcttc gcccgcgaag gagccgcgca
    25381 cgagcgagcc gcgtacggcc gaccccacgc ccaccgcttc cgcccccgcc gagaccgcgc
    25441 gcacccaggg cgacagcacg ccggtggctt ccaccggggc cgccgactcg gggccgtcga
    25501 cgccgttgct ggcgggcggc gccgccgcgg tgctggtgct caccgggggc gccgccctgg
    25561 cgctgcgctt gcgcaggagg tgaactccgg cgcggtgggg gtcagttgac gtagaccgcc
    25621 gcgccgctcg cggtcaccgg ggcgtacttg gcggtgaagt agccgttggc gaagcagagg
    25681 gaggagccgg agaccttggc gaacgccgcc ctgttgaagt tgatcgtgtt gtcgtcgttg
    25741 ctcgccgtgc cggtcaggct gggggcctgg tagacgcagt tgatgctgcc gagcagggtg
    25801 cgcaggacga ccgtggtctg gatggtggag cccgcggccg gggtgacggt cacggtgccg
    25861 tccgaggcca cggcggcgct gtacggcagg ttgttgaccg tgatgctggt gacgccgagc
    25921 acgccgacca cgttggtggt gcagctggcg gcgtcgaagg tgtgcgcgga gaccgactcc
    25981 gtcgcggtgc cgggcgcacc ggggttgtcc gtcacggagg ccgtgaactg ggacgacgtg
    26041 caggagatgc cgctcgtgcc ggtggcgctg gagtagaacg tggcagcggt gccgctcgcc
    26101 agcggtgcgg tgagcacctc gccggccgcg accgccgtac cgccgacgga gccggtggtc
    26161 aggacggcgc cgtcggccgc cgatgcgggg ccggccagcg ggagggtgag ggcggcgacg
    26221 gtgccggcga gggtgaggag ggtgcgggtg cgcatggggg tgtacctcgt ctttcgttgc
    26281 ggggagtgcg ccgttgccgg tccgtgccgc cttctccgta cggcacggac cggcaacgac
    26341 aggggcggcc gacacggacc gaggggggaa gcgaccgtga cggcgggtgg agggacccca
    26401 gggaggagat cccaggaaaa ggaaatgtga aggacatcag gtccgggaac g
//
