LOCUS       NZ_BNBM01000001        22234 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces lanatus strain JCM 4588 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNBM01000001
VERSION     NZ_BNBM01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces lanatus
  ORGANISM  Streptomyces lanatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1203604)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 61X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014655715.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 05:46:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,254
            CDSs (total)                      :: 9,172
            Genes (coding)                    :: 8,973
            CDSs (with protein)               :: 8,973
            Genes (RNA)                       :: 82
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 199
            CDSs (without protein)            :: 199
            Pseudo Genes (ambiguous residues) :: 0 of 199
            Pseudo Genes (frameshifted)       :: 83 of 199
            Pseudo Genes (incomplete)         :: 153 of 199
            Pseudo Genes (internal stop)      :: 16 of 199
            Pseudo Genes (multiple problems)  :: 50 of 199
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 452457
            Orig. end                         :: 474691
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNBM01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22234
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22234
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22234
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12234](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12234)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(1607..1621)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     gene            1887..2690
                     /locus_tag="IE325_RS01965"
                     /old_locus_tag="GCM10018780_04000"
     CDS             1887..2690
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640019.1"
                     /locus_tag="IE325_RS01965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04000"
                     /product="serine protease"
                     /protein_id="WP_190067859.1"
                     /transl_table=11
                     /translation="MTAPEYWVDLHRAGQRLGGGFLLNRTFVLTALHCLRGLALEDQVD
                     IELCDGERVEGRICRQDEKADLALVEISADQRVGLPVPAADRARDGGRWRGPYRPTTTD
                     VHLSGLVSGTAHHLCVGGATIEALQLTADQHLGDYSGYSGGPVEGVPDDRAGMPTMLGI
                     LIEQTPDRADPTRAANVLIAATIGEAMSRFDQFDVGHLIDVVRPPRSRQRKEPTAPARY
                     ADAEKLLLQFDDWADRGLIDPVSAAEMKAEAVRRLIDRELGGGDV"
     gene            2687..4381
                     /locus_tag="IE325_RS01970"
                     /old_locus_tag="GCM10018780_04010"
     CDS             2687..4381
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="IE325_RS01970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04010"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_190067860.1"
                     /transl_table=11
                     /translation="MTERPEAWDTALCLAEQARDGDTAARDQLHDAVQRLCGDPELLSY
                     RDPGQTVAHLTGLLDDLGEPEIAQSLLRQCVSRLTAKGTDGGSPRAALNHIAVALAERG
                     QLPAAQRVSSTAATLGRPSSRADFTDLTITFANLAAVELGLDDPETAARSAERAAGFLR
                     MSPVDGRPEALLELRLRVVSLLTAAARARNDHAKADAHLDDLGDIARALVAELGAEHPK
                     SLSALVTLALAECESATAAGDRERSERAVDVLLIAAQKAAAFAGRRHPLAVSALASLAA
                     AEGLVAAGSGDGERLTRARALMAARVRAESRPAVRHAAVPAPRTFSLLGPVRARRDDRT
                     VALASDRERLLLAKLLLNAGRVVPTDELMRAAWGDDFQVSPLRLLLFHMARLQRDLGPD
                     VLVNEPSGYLIRLTPGSLDLHEARELVERSRRAQGSEQARELLNQALALWTGDPLAGLP
                     GPYAREQRALLRAWHVDLVEARLELDLELGRDHDELITELADRVAGNPQSQRLLELLLA
                     TLDREAASDEAPDRYAGARRVLADALGVAPSASLRDLARRIHEEETP"
     gene            complement(4385..6454)
                     /locus_tag="IE325_RS01975"
                     /old_locus_tag="GCM10018780_04020"
     CDS             complement(4385..6454)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075870.1"
                     /locus_tag="IE325_RS01975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04020"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_190067861.1"
                     /transl_table=11
                     /translation="MHVTPTRRRSYRGVLTAALGGLLLSLLTASPPSGAAAAAASDHQA
                     ETATISQGTVATNHSGYTGTGFVDYTNVTGSYVEFTVRADAAGGASLALRYANGTGADR
                     PMDISVGGKVIASKVSFPPTANWTTWATKTVNADLTAGTNKIRATATTTAGGPNLDKLT
                     VGTTADTQTPTRPGAPTCSAITEDGLTLTWGAATDDVAVTAYDIYEHGNKIGEAAGSAT
                     TSKLTGLTPATTYNLTVIARDAAGNASPASPAVDCTTKTSSDTSPPTGPGTLSYTDVTA
                     NSAKLSWGAATDDKAVTAYDIRSGSTVYKTVTGTPPATSATLTGLACDSPYNLNVVARD
                     AAGNASPQSNAVTFTTRACATDGGVPSSIGTVSTGWSIPWGTYWMPDGNSALVTERDSF
                     KVFKLTKDGTRTQVGKVPNAVTTDGEGGLLGVAVDPDWATNHRVYFMHTASEGNRIARM
                     TYDGSSLSGYTVLLQGIKKNRYHNGGRLAFGPDGLLYASTGDAQTSSLAQDKNSLNGKI
                     LRLTTDGKAAPGNPFGSYVYSLGHRNPQGLAFDKNGRLWEAEFGNSSFDELNLIKPGAN
                     YGWPICEGTCSNAGMTNPKKTWRVSEASPSGIAIIRNVIYMAALRGERLWRIPIDGDTE
                     NVGSATAYYVGTYGRLRTVTRVPGADQLWLSTTNSDNNGGEPDGADKIFRVSIS"
     gene            complement(6515..8014)
                     /locus_tag="IE325_RS01980"
                     /old_locus_tag="GCM10018780_04030"
     CDS             complement(6515..8014)
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058227.1"
                     /locus_tag="IE325_RS01980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04030"
                     /product="glycoside hydrolase family 28 protein"
                     /protein_id="WP_190067862.1"
                     /transl_table=11
                     /translation="MRPVRPLLPALLGFLVALGLSQPPAVATTAAPPVFDVRSYGAEGD
                     GSANDTPAIQRAIDAAHAVGGGTVLVPAPGVYKSKNTIRMKSHVTLKVDRGATVQGAGA
                     DTYDPPEPNPYDEYQDYGHSHFHNAMIHGDRLTDIAFTGGGVIDGGGNLITGTPKSGEA
                     DKIISLTRCDGLRLGDGLTLRRGGHFAALINGCRDVTSDRLTIDTASDRDGWNIISTTD
                     VTVTNAHFEANDDALAFKSDYALGAKLPNGHARVGDSYLSARCCNALMFGSETCGDFTD
                     YRFERIRIEGSDKSGLGMVSMDGAKISDVHYRDITMTGVRSPIMQKIGTRKRCGNDPGV
                     GSISDITYDDITATGTDPSFSPTLWGEPGPHRIRNVRFTHVDLTVPGGHDPMDTGVPSN
                     DPKNYNPNSIGTRPAYGWYLHHTDGITFTDSSVRLAADDSRPAVIANNGSSLRFTRFTA
                     QRGSGSPYDMGFQTVTGACVTDSHTTTGGALRVTGTGSDDC"
     gene            complement(8027..8815)
                     /locus_tag="IE325_RS01985"
                     /old_locus_tag="GCM10018780_04040"
     CDS             complement(8027..8815)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385910.1"
                     /locus_tag="IE325_RS01985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04040"
                     /product="heparin lyase I family protein"
                     /protein_id="WP_190067863.1"
                     /transl_table=11
                     /translation="MGTSRRVLLGAALGGVASAAVGLPAATHARAASWQLKWSPSASSD
                     GMRAFETIEDDRADSHPGGQPHIYATGDNWRFNMHMSDRDTSTDRQRQEVTGLRTSGSS
                     YLKWTQGQTWRITYSMYIPSSLKATTSFTHIMQMKQPGSGSSPIVVQSLRRVNGAQTIE
                     LKLFDSDTLVGRTDLAPLHDKWTDVDFQIKVGNGSAGSVRWILKSGGTTVIDKSKSGVD
                     TFLADRVRPKWGIYRSLGDTSGSLQDCHLLLTNLRGYQLV"
     gene            complement(8820..10004)
                     /locus_tag="IE325_RS01990"
                     /old_locus_tag="GCM10018780_04050"
     CDS             complement(8820..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119200.1"
                     /locus_tag="IE325_RS01990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04050"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_190067864.1"
                     /transl_table=11
                     /translation="MRRLHALLTTTVLAAATLTAVPTAAAEPAPAMAMPVTAPVTTADW
                     SVAMVDSTTARYTPTTIGGWSYPVGLYLYGQYLVFRRTHNPQYLAYIKSYVDRFVAADG
                     SMSQSFNNLDSMQAGRLLTILHHETGDDRYRIAARKIRERLDTYPRTEDGGFWHADTAS
                     RAHQLWADGVYMVNPFLVEYGKEFDDSSYANDEAAKQLYLYGSHLQVGNGLLRHAYDES
                     RTATWSDQATGLAPEHWCRAVGWYSMAMVNVLDAIPGDHPRRQALLRILRKLAKGLERT
                     QDPSTGRWFQVIDKGDRADNWTETSCSSMFTYALSRGAQQGYLDRHYATVAERGYQGVL
                     KKVSLGADGRTDLTDISIGTNVGDYAYYIARTRATNDFHGLGAFLIMNEQLRSD"
     gene            complement(10001..11083)
                     /gene="pqqE"
                     /locus_tag="IE325_RS01995"
                     /old_locus_tag="GCM10018780_04060"
     CDS             complement(10001..11083)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669244.1"
                     /locus_tag="IE325_RS01995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04060"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_190067865.1"
                     /sec_met_domain="PF04055 (E-value: 7.9e-25, bitscore: 84.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.8e-07, bitscore: 26.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.9e-10, bitscore:
                     35.0, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDPPWALLAELTHRCPLRCGYCSNPVELVGRSTELTAGEWAGV
                     FRQAADLGVVQTHLSGGEPLLRRDLPDIVAAAERAGLYTQLVTSGVGLGERRLDELVAA
                     GLHSVQLSVQHADPDASDRIAGARSFAAKERAARLIRAAGLPFGLNIVLHRTNIDALDD
                     LIALGVAWGADRIELAHTQFHGWALRNRATLLPTRNQVDRARTTLTRWRERPGPAPELI
                     WVTPDHIDGVAKPCMGGWGALSLTVAPDGTVLPCPAAAALPGLDPPNVRDRQLDWIWRE
                     SRAFNAYRGDSWMRDPCRSCGLSSTDHGGCRCQAFALTGDATRTDPACRLSPDHALIRD
                     LVDSPRPAATPVHAYREGAP"
     gene            complement(11080..11334)
                     /gene="pqqD"
                     /locus_tag="IE325_RS02000"
                     /old_locus_tag="GCM10018780_04070"
     CDS             complement(11080..11334)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645346.1"
                     /locus_tag="IE325_RS02000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04070"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_190067866.1"
                     /sec_met_domain="PqqD_RRE (E-value: 5.2e-20, bitscore:
                     67.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-10, bitscore: 37.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWRPTLARSVVLRHDRVRGTDLLLLPERVVVLHGNAGGVLRLCD
                     GSREVEDIVAELAARFPGAPVAGEVPEFLETLRKEGWLR"
     aSDomain        complement(11086..11325)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE325_RS02000_PqqD_RRE.1"
                     /evalue="1.40E-21"
                     /identifier="RREFam006.1"
                     /label="IE325_RS02000"
                     /locus_tag="IE325_RS02000"
                     /protein_end="83"
                     /protein_start="3"
                     /score="67.0"
                     /tool="antismash"
                     /translation="RPTLARSVVLRHDRVRGTDLLLLPERVVVLHGNAGGVLRLCDGSR
                     EVEDIVAELAARFPGAPVAGEVPEFLETLRKEGWL"
     gene            complement(11515..12234)
                     /gene="pqqC"
                     /locus_tag="IE325_RS02005"
                     /old_locus_tag="GCM10018780_04080"
     CDS             complement(11515..12234)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079177.1"
                     /locus_tag="IE325_RS02005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04080"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_373315072.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.3e-84, bitscore:
                     279.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATRVHAHGAAAPWTTTEFTGRLRAVTAARYHDRHPFNLRMHKG
                     ELTPAELRRWIANRFHYQRHIPVKDALILAKLERPAPRRAWLRRIRDHDGTAEGEGGIE
                     RWLRLGEAAGLDREELWDASRVLPGVRLAVDGYVNFCRLSPVVEAVAASLTELSAPDLM
                     RTRIDAFETHYPWIDPAGLAYFRTRVDQGARDGEEALALVLDQARTREQQERAVGALGF
                     KCDVLWALLDAVDGGGP"
     gene            complement(12257..12406)
                     /gene="pqqA"
                     /locus_tag="IE325_RS02010"
                     /old_locus_tag="GCM10018780_04090"
     CDS             complement(12257..12406)
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_167353750.1"
                     /locus_tag="IE325_RS02010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04090"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_190067867.1"
                     /transl_table=11
                     /translation="MDEKLLRTLPALATEQIIQETSEESVWRSPGYTVVDTALEVTAYA
                     LADR"
     misc_feature    complement(12466..12481)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    complement(12541..12556)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            12718..13548
                     /locus_tag="IE325_RS02015"
                     /old_locus_tag="GCM10018780_04100"
     CDS             12718..13548
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996480.1"
                     /locus_tag="IE325_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04100"
                     /product="aldo/keto reductase"
                     /protein_id="WP_190067868.1"
                     /transl_table=11
                     /translation="MSSKVPPITLNNGVEMPQLGFGVWQVPDGEAEEAVGTALEAGYRS
                     IDTAAIYGNEEGTGKAIATSGLPREDIFVTTKLWNGDQGYDSTLRAFDVSLGKLGLDYV
                     DLYLIHWPAPSRDKYVDTYKAFEKLHADGRIRAIGVSNFLPEHLERLLDETSVVPAVNQ
                     IELHPHLQQHTSRAFHAERGIATEAWSPLGSGKGLLEVPAIVAIAQKHGRTPAQIVLRW
                     HLQIGNIVIPKSVTPSRIKENIEVFDFSLDDEDLAAISALNEDRRIGSDPATVS"
     gene            complement(13656..14267)
                     /locus_tag="IE325_RS02020"
                     /old_locus_tag="GCM10018780_04110"
     CDS             complement(13656..14267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676057.1"
                     /locus_tag="IE325_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04110"
                     /product="hypothetical protein"
                     /protein_id="WP_190067869.1"
                     /transl_table=11
                     /translation="MFVRAIYTTGDPTKIDTAIRALNTEGRDLLEDRPGYRGASVFVDR
                     TLGKLLAASWWESEQARQNSDEVLRERRVSMLEPFLGTVSVDNYEALVFHQARQPQAGG
                     GLRVSRLEFDPRDTDLLADTFRATVVPRLETLPGLARASLLVDRARGRGLVGVIFVDQS
                     SLAASRAGQAAARHEGAAKAHVAVTGLEEFEVVFTDVRGD"
     gene            14470..15165
                     /locus_tag="IE325_RS02025"
                     /old_locus_tag="GCM10018780_04120"
     CDS             14470..15165
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073097.1"
                     /locus_tag="IE325_RS02025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04120"
                     /product="glycoside hydrolase family 75 protein"
                     /protein_id="WP_190067870.1"
                     /transl_table=11
                     /translation="MRIRTLTLIAASGAALLAAGLLPTSASGHPQPPSLQEGSVSAADL
                     LAKVTSCSQISNGKYRTDEETSATVPVCGKNGAVFWKADMDIDCDGQRTAKCNADTDPW
                     YQPDTAFHQSNGKPLRADTLPYVVVPSVSGTWDYSGAGIKGGGVVAVIHDNQVVYAVVG
                     DTGPQRIIGEASYATAERLGIDPDPENGGTDSGVTYILFKNSKVSPIENHGAAVTLGEK
                     LAKEFIQNN"
     gene            complement(15179..15880)
                     /locus_tag="IE325_RS02030"
                     /old_locus_tag="GCM10018780_04130"
     CDS             complement(15179..15880)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-168). E-value: 1.4e-10. Score:
                     33.3. Matches aSDomain:
                     nrpspksdomains_IE325_RS02030_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922768.1"
                     /locus_tag="IE325_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04130"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_190067871.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 9.2e-07,
                     bitscore: 24.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDSPVALITGGGSGIGAAVARQLLDAGHRVTVTGRGEARLRAFA
                     EELGEPEGLLAIVGNAAEYTDVQVAVDATLKAFGRLDTVVANAGFATHDTVAEGDPSGW
                     TEMVLTNVLGPALLIRASIDALKETRGRIVLVGSVAGFVNGPGNIYGATKWAVTGLAEN
                     TRRQVTDWGVGVTHIAPGRVETPFWDSYGSLPPGHLLTADQIADSVVWAVRQPDGVDVN
                     TVVVRPLGQPN"
     aSDomain        complement(15377..15865)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE325_RS02030_PKS_KR.1"
                     /evalue="1.40E-10"
                     /label="IE325_RS02030_PKS_KR.1"
                     /locus_tag="IE325_RS02030"
                     /protein_end="168"
                     /protein_start="5"
                     /score="33.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALITGGGSGIGAAVARQLLDAGHRVTVTGRGEARLRAFAEELGE
                     PEGLLAIVGNAAEYTDVQVAVDATLKAFGRLDTVVANAGFATHDTVAEGDPSGWTEMVL
                     TNVLGPALLIRASIDALKETRGRIVLVGSVAGFVNGPGNIYGATKWAVTGLAENTRRQV
                     "
     CDS_motif       complement(15791..15859)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE325_RS02030_0001"
                     /evalue="3.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE325_RS02030"
                     /protein_end="30"
                     /protein_start="7"
                     /score="16.4"
                     /tool="antismash"
                     /translation="LITGGGSGIGAAVARQLLDAGHR"
     misc_feature    15895..15912
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(16006..16911)
                     /locus_tag="IE325_RS02035"
                     /old_locus_tag="GCM10018780_04140"
     CDS             complement(16006..16911)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007504766.1"
                     /locus_tag="IE325_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04140"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_190067872.1"
                     /transl_table=11
                     /translation="MAHNHHGDHGDHHAGHHHHDHADIDWGEMAPLLEAQAELFTPLYE
                     HAMAWLAKRQTEPGLVVDAGSGPGVVACLLADTFPGARIVAVDGSEPLLERARARAERL
                     GVADRFGTLAGELPEILDDLDYPADLLWASRSLHHLGDQRAALAAFADRLAYGGTLALQ
                     EGGLPTRFLPRDIGFGRPGLHARLDALEAEWFAQMRADLPRSVAETEDWPALMTAAGLR
                     PSGTRTFLLDLPAPTTDRARAYAAAVLTRIREGVAERLDADDRATLDRLLDPEDKASVH
                     HRPDLFVLAAQTVYTAVRTR"
     gene            17012..17818
                     /locus_tag="IE325_RS02040"
                     /old_locus_tag="GCM10018780_04150"
     CDS             17012..17818
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119195.1"
                     /locus_tag="IE325_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04150"
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_190067873.1"
                     /sec_met_domain="PhyH (E-value: 4.9e-10, bitscore: 36.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPTGPSTHDGPMDDEMVERFLRDGFVKIEGAFPPRVAEHCARLL
                     WRETGYDAQDPATWKDPVHWVYDMAQGPFAAAANTPALHEAFDLLVGEDRWQSRYSLGS
                     FPLRFPHEEEPDDAGWHIEASYVPEGAEHPHTNLASKERALLMLFLFSEVTEADAPTRI
                     RVGSHLDVPKVLEPYGEKGASFLELGPKVAEASAHRPLAHATGRPGDVYLCHPFLVHAA
                     QPHHGTRPRFMAQPPLHTSVPLELERPDGNYSAVEFAIRRGLAQEI"
     gene            complement(17929..19647)
                     /locus_tag="IE325_RS02045"
                     /old_locus_tag="GCM10018780_04160"
     CDS             complement(17929..19647)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922770.1"
                     /locus_tag="IE325_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10018780_04160"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_190067874.1"
                     /transl_table=11
                     /translation="MSRTRTAMLAALALVAGASGTALAADPGGIGTAAVPCTVDYKVQN
                     QWDTGFTAAVTVTNQGAAKSNWSVKWSYAGNQKVTSGWNAKIGQSGADVTAANETYNAT
                     LATGGSVSFGFQGTYSGSNAIPATFTLDGVTCNVDDGGGGPTDPPDPDPTGPKVDNPYS
                     GAKVYVNPEWSAKAAAEPGGSRIASQPTGVWLDRIAAINGVNGGMGLRDHLDEALTQKG
                     SGELVVQLVIYNLPGRDCAALASNGELGPTELGRYKTEYIDPIAAILADPKYAALRIVT
                     TIEIDSLPNLVTNTGSRPTATPQCDVMKANGNYQKGVGYALNKLGDVANVYNYIDAGHH
                     GWIGWDDNFAPSATVMKEAATSEGATMNDVHGFIANTANYSALKENNFTINDSVGGKSV
                     RESKWVDWNRYTDELSFAQAFRQQLVTTGFNSGIGMLIDTSRNGWGGSARPAGPGATTD
                     VDTYVNGGRYDRRIHVGNWCNQSGAGLGERPQAAPAAGIDAYVWIKPPGESDGASSEIP
                     NDEGKGFDRMCDPTYTGNPRNGNNMSGALPNAPLSGHWFSAQFQQLMQNAYPPLS"
     misc_feature    complement(19811..19825)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 25.36"
                     /tool="antismash"
     misc_feature    19838..19855
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.87"
                     /tool="antismash"
     misc_feature    complement(19954..19968)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    19955..19969
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    20795..20807
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
ORIGIN
        1 caggaggacc cgttgtatgt cgtcctgggc cgcaaggacg aggacgacca ctggcgggac
       61 gtcaccgccg ccgagttccg cgacgaggtc ctggccctgg ccaagggcct gctcgcccgg
      121 ggcatccggt tcggcgaccg cgtcgcgatc atgtcccgca cccgctacga gtggacgctc
      181 ttcgacttcg ccctgtggac gatcggcgcc caggtggtgc cgatctaccc cacctcctcg
      241 gccgagcagt gcttctggat gctgtacgac gccgagtgct cggcggcgat cgtggagcac
      301 gaggaccacg cgatgacgat cgccaccgtc atcgaccggc tgccccggct gcaccagctg
      361 tggcagctgg actcgggcgc cgtgcaggag ctgtacgacg ccggtgccca cctcgacgac
      421 gacgtcgtcc accgccaccg gcaggcggtc accccggact cggtcgcgac gatcatctac
      481 acctcgggca ccacgggccg ccccaagggc tgtgtgatct cgcacggcaa cttcatgtac
      541 gaggcggaca ccgtcatcga ccgctgggag ccggtgttcc actccaagaa gggcgacgag
      601 gcggcgaccc tgctgttcct gccgctcgcg catgtcttcg gccggatggt ggaggtcgcc
      661 gcgatccgcg gccgggtccg cttcggtcac cagccgcaga tgaacgccgc cgcgctgctg
      721 cccgacctcg ccgcgttcaa gccgacgttc ttcctggccg tgccgtacat cttcgagaag
      781 gtcttcaacg ccgcccgccg caaggccgag aaggagggca ggtcgggcgc cttcgagaag
      841 gccgtcgagg tcgccgtgaa gtacgcggac gccgtggagg ccaaggcgtg gggcatcggg
      901 ccaggaccgt cggcggggct gcggatgcag caccagctct tcgacaagct cgtctactcc
      961 aagatgcggg cggcgatggg cggccgtatc cggcacgcga tgtccggcgg ctcggcgatg
     1021 gaccggcggc tcgggctgtt cttcgccggc gcgggcgtgc acatctacga gggctacggc
     1081 ctcaccgagt ccacggcggc ggcgaccgcc aacccgcccg agcgcacccg ctacggcacc
     1141 gtcggtcggc ccatccccgg cacgaccgtg cacatcgcgg acgacggcga gatctggctg
     1201 cacggcgcca acgtcttcca gggctatctc aacaaccaga aggccaccga cgagtccctg
     1261 cacgacggct ggctggccac cggtgacctg ggctccctcg acgaggacgg cttcctgacc
     1321 atcaccggcc gcaagaagga gatcctggtg acctccggcg gcaagagcgt gtcgccgggc
     1381 ctgctggagg aacgcgtccg cgaccatccc ctggtctccc agtgcatagt cgtcggcaac
     1441 gaccgcccgt acatcgcggc cctggtcacc ctcgaccagg aggccgtgga gcactggctg
     1501 atgatgcgcg acaagcccca gatgacagcg gcccagctgg tgcgcgacgc cgacctggag
     1561 acggaggtgc ggcgcgcggt cgtcgccgcc aacaccctgg tctcgcaggc cgagtcgatc
     1621 cgtaccttcc gtatcctcgc ccagcctttc accgaggagc atggactgct cacgccgtcc
     1681 ctgaagctga agcgcaaggc gatcgagaac gcgtactcgg gcgaggtcga ggccctgtac
     1741 caggcgtgaa ctgcgccccc gcggcactcg cccgcaccaa ttctcccccg atacgcttga
     1801 gttgatatcg gccaccggcg cccagggcgc ccagtgcacg ggggacgaac ggtcatggca
     1861 gacatcgggc gcacaccggg gacgccgtga ccgcaccgga gtactgggtc gacctgcacc
     1921 gggccgggca gcggctcggc ggcgggtttc tgctcaaccg tacgttcgtg ctcacggcac
     1981 tgcactgcct gcgtgggctg gccctcgagg accaggtcga catcgaactc tgcgacggtg
     2041 aacgcgtcga ggggaggatc tgccgccagg acgagaaggc cgatctggcg ctcgtcgaga
     2101 tctccgccga ccagcgggtg ggcctgccgg tgcccgccgc cgaccgcgcc cgggacggcg
     2161 gccgatggcg cggcccctac cgcccgacca cgaccgacgt gcacctcagc ggcctggtga
     2221 gcggtacggc ccatcatctg tgcgtcggcg gcgccaccat cgaggcgctg caactgaccg
     2281 cggaccagca cctgggcgac tactccggct actcgggcgg ccccgtcgag ggcgtcccgg
     2341 acgacagggc cgggatgccg acgatgctgg gcatcctcat cgagcagacc ccggaccgcg
     2401 ccgacccgac ccgcgccgcc aacgtgctca tcgccgccac catcggggag gcgatgagcc
     2461 gcttcgacca gttcgacgtc gggcacctca tcgacgtggt caggccgccc cggtcgcggc
     2521 agcgaaagga gccgacggcc ccggcgcggt acgcggacgc cgagaagctg ctgctccagt
     2581 tcgacgactg ggccgaccgc gggctgatcg acccggtgag cgccgcggag atgaaggccg
     2641 aggcggtcag acggctcatc gaccgggagt tgggcggtgg tgacgtatga cggagcggcc
     2701 cgaggcgtgg gacaccgcgc tctgcctggc cgagcaggcg cgggacggcg acacggcggc
     2761 gcgcgatcag ctccacgacg cggtccaacg gctgtgcggg gaccccgagt tgctgtcgta
     2821 ccgggatcct ggccagaccg tggcgcacct caccggtctc ctcgacgacc tcggcgaacc
     2881 ggagatcgca cagtcgctgc tgcggcagtg cgtgtcccgt ctgacggcga aggggaccga
     2941 tggcgggtcc ccgcgtgcgg cgctcaatca catcgccgtc gcactcgcgg agcgtggtca
     3001 actaccggcc gcccaaaggg tgtcgtccac agcggccacc ctgggccggc cgagctcccg
     3061 cgcggacttc acggacctga cgatcacctt cgccaatctc gcggcggtcg aactcgggct
     3121 ggacgacccc gagaccgccg ccagatccgc cgagcgggct gcggggttcc tccgcatgtc
     3181 ccccgtggac ggccgccccg aagcgcttct cgaactgcgg ctgcgagtgg tctcgttgct
     3241 gacggcggca gcgcgcgccc gcaacgatca cgccaaggcc gacgcccacc tcgacgacct
     3301 cggtgacatc gcccgcgctc tggtggcgga gctcggcgcg gaacatccca agtccctctc
     3361 cgcgctggtg actctggccc tcgccgagtg cgagtcggcg acggcggccg gcgaccgcga
     3421 acggtcggag cgcgccgtgg acgtcctgct catcgccgcg cagaaggcgg cggcgttcgc
     3481 gggtcgtcgt caccctctcg cggtgtccgc gctggcgagt ctcgcggcgg cggagggcct
     3541 ggtggccgcg gggtcgggag acggcgagcg tctcacgcgg gcaagggcgc tgatggccgc
     3601 gagggtgcgg gccgagagcc gacccgcggt gcggcacgcc gccgttcccg caccgcggac
     3661 cttcagcctg ctcggtccgg tccgtgcccg gcgtgacgac aggacggtgg ccctcgcctc
     3721 cgatcgcgaa cgcctgctgc tggccaagct gttgctcaac gcggggcgcg tcgtccccac
     3781 ggacgagctg atgcgcgccg cgtgggggga cgatttccag gtgtcgccgc tcaggctgct
     3841 gctcttccac atggcgcggc ttcagcgtga cctcggtccc gatgtgctgg tgaatgaacc
     3901 ctcgggctat ctgatccggc tcacccccgg gtcactcgat ctccacgagg cgcgggagct
     3961 ggtggagcgg agccgtcggg cccaaggatc ggaacaggcg cgggagttgc tgaaccaggc
     4021 gctggcgctg tggaccggcg accctctggc cggcctgccc ggcccctacg ccagggagca
     4081 gcgggcactg ctgcgggcat ggcatgtgga ccttgtcgaa gctcgtctgg agctcgatct
     4141 ggagctgggc cgcgaccatg acgagctgat caccgaactg gccgaccggg tcgccgggaa
     4201 tccgcagagc cagcgcttgc tggagctgct cctggccacc ctggaccgcg aggcggcgtc
     4261 ggacgaggca ccggaccggt acgccggcgc gcgacgcgtt ctcgcggacg cgctcggggt
     4321 ggccccgagc gcgtcgttgc gggatctggc gcgccgcatc catgaggaag agacgccgtg
     4381 acggtcagct gatgctcacc cggaagatct tgtccgctcc gtccggctca cccccgttgt
     4441 tgtcgctgtt ggtcgtggac agccacagct ggtcggcgcc cggcaccctg gtgaccgtgc
     4501 ggagcctgcc gtaggtaccg acgtagtacg cggtcgccga gccgacgttc tcggtgtcgc
     4561 cgtcgatcgg gatacgccag aggcgttcgc cgcgcagggc ggccatgtag atgacgttgc
     4621 ggatgatggc gatgccgctc ggggaggcct cggagacacg ccaggtcttc ttggggttgg
     4681 tcatgccggc gttcgagcag gtgccttcgc agatcggcca gccgtagttg gcgcccggct
     4741 tgatgaggtt gagctcgtcg aaggagctgt tgccgaactc cgcctcccac aggcggccgt
     4801 tcttgtcgaa ggccaggccc tgggggttgc ggtggccgag ggagtagacg tagctgccga
     4861 aggggttgcc gggggccgct ttgccgtccg tcgtcaggcg caggatcttg ccgttgaggg
     4921 agttcttgtc ctgggcgagg gacgaggtct gggcgtcgcc ggtggaggcg tacagcaggc
     4981 cgtcggggcc gaaggcgagg cggccgccgt tgtggtagcg gttcttcttg atgccctgga
     5041 gcagcacggt gtagccgctc agcgagctgc cgtcgtaggt catgcgtgcg atgcggttgc
     5101 cctcggaggc cgtgtgcatg aagtagacgc ggtggttggt ggcccagtcg gggtcgacgg
     5161 cgacgccgag cagtccaccc tcgccgtccg tggtgaccgc gttgggcacc ttgccgacct
     5221 gtgtcctggt gccgtccttg gtcagtttga acaccttgaa actgtcgcgt tcggtgacca
     5281 gggcgctgtt gccatcgggc atccagtacg tcccccaggg gatgctccag ccggtcgaca
     5341 cggtgccgat ggacgacggg acaccgccgt cggtggcgca ggcccgggtg gtgaaggtga
     5401 ccgcgttgct ctgcggggag gcgttcccgg cggcgtcgcg ggccacgacg ttcaggttgt
     5461 aggggctgtc gcaggccagc ccggtgagcg tggccgaggt ggcgggcggg gtgccggtga
     5521 ccgtcttgta gacggtggag ccgctgcgga tgtcgtacgc cgtgaccgcc ttgtcgtccg
     5581 tcgcggcgcc ccagctcagc ttggcgctgt tcgcggtgac gtcggtgtag gacagggtgc
     5641 cgggtccggt cggcgggctg gtgtcggagc tggtcttcgt cgtgcagtcc acggccgggc
     5701 tggcgggcga ggcgttgcct gcggcgtcgc gggcgatgac cgtgaggttg taggtggtgg
     5761 ccggggtgag cccggtgagc ttcgaggtgg tcgcgctgcc cgcggcctcg ccgatcttgt
     5821 tgccgtgctc gtagatgtcg tacgcggtca ccgccacgtc gtcggtcgcg gcgccccagg
     5881 tcagggtgag gccgtcctcg gtgatggcgg agcaggtcgg tgcgccgggg cgggtcgggg
     5941 tctgggtgtc ggccgtcgtg cccacggtca gtttgtcgag gttggggccg ccggcggtgg
     6001 tggtcgcggt ggcgcggatc ttgttggtac cggcggtgag gtcggcgttg accgtcttgg
     6061 tggcccaggt ggtccagttc gcggtgggcg ggaaggacac cttcgacgcg atgaccttgc
     6121 ccccgaccga gatgtccatg ggccggtcgg cgccggtgcc gttggcgtag cgcagggcca
     6181 gcgaggcgcc gcccgccgcg tccgccctca ccgtgaactc gacgtacgag ccggtcacat
     6241 tggtgtagtc gacgaagccg gtgcccgtgt agccgctgtg gttggtggcc accgtgccct
     6301 gcgagatcgt cgcggtctcg gcctggtggt cactcgcggc ggcggccgcg gcaccggacg
     6361 gtggggaggc ggtgaggagg gacagcagca ggccgccgag ggcggcggtg agcacgcccc
     6421 ggtaggagcg gcgtctggtg ggggtgacat gcatgggggg tccacctcca ggtggggggg
     6481 atgtcctacg ggtgcgggcg cggatgaggg gcggtcagca gtcgtcggag ccggtgccgg
     6541 tgacgcgcag ggcaccgccc gtcgtggtgt ggctgtcggt cacgcaggcg ccggtcaccg
     6601 tctggaagcc catgtcgtac ggcgatccgc tgccgcgctg ggccgtgaaa cgggtgaagc
     6661 gcagcgagct gccgttattg gcgatgaccg cggggcggga gtcgtcggcg gcgaggcgta
     6721 cggagctgtc cgtgaaggtg atgccgtcgg tgtggtggag gtaccagccg taggcggggc
     6781 gggtgccgat gctgttgggg ttgtaattct tggggtcgtt gctcggcacg cccgtgtcca
     6841 tggggtcgtg gccgccgggc acggtgaggt cgacgtgggt gaagcggacg ttcctgatgc
     6901 ggtgcgggcc cggctcgccc cacagggtcg ggctgaacga cgggtcggtg ccggtcgcgg
     6961 tgatgtcgtc gtaggtgatg tcgctgatgg agcccacgcc ggggtcgtta ccgcagcgtt
     7021 ttcgggtgcc gatcttctgc atgatcggtg agcggacgcc ggtcatggtg atgtcgcggt
     7081 agtggacgtc ggagatcttc gcgccgtcca tggagaccat gccgagcccc gacttgtcag
     7141 agccctcgat acggatccgc tcgaaccggt agtcggtgaa gtcgccgcag gtctccgagc
     7201 cgaacatcag ggcgttgcag caccgcgccg atagatagga gtcgcccact ctggcatggc
     7261 cgttgggaag cttggcgccc agcgcgtagt cgctcttgaa ggcgagggcg tcgtcgttgg
     7321 cctcgaagtg ggcgttggtg acggtgacgt cggtcgtgct gatgatgttc cagccgtcgc
     7381 ggtcgctagc ggtgtcgatg gtgagccggt ccgaagtgac gtctcggcag ccgttgatga
     7441 gggccgcgaa gtggcctccg cggcgcagcg tcaggccatc gcccagccgc agtccatcgc
     7501 accgcgtcag cgagatgatc ttgtcggcct cgccggactt aggggtgccg gtgatcaggt
     7561 tgccgccgcc gtcgatgact ccgccgccgg tgaaggcgat gtcggtcaga cggtcgccgt
     7621 ggatcatcgc gttgtggaag tggctgtggc cgtagtcctg gtactcgtcg tacgggttcg
     7681 gctcgggcgg gtcgtacgtg tccgcgccgg cgccctgaac cgtggcgccc ctgtccacct
     7741 tcagcgtcac atggctcttc atccggatcg tgttcttgga cttgtagacg ccgggtgccg
     7801 ggacgaggac ggttcccccg ccgacggcgt gcgcggcgtc gatcgcccgc tggatcgccg
     7861 gggtgtcatt ggcggagccg tcgccctcgg cgccgtagga acgcacgtcg aagacaggcg
     7921 gtgcggcggt cgtcgcgacg gccgggggct gggacaggcc gagtgccacg aggaagccga
     7981 gcagggccgg taggagaggg cgtacgggtc tcatctggcc gtcccctcat acgagttgat
     8041 agccgcggag gttggtgagc agcaggtggc agtcctggag tgagccggag gtgtcgccga
     8101 gggaacggta gatgccccac ttggggcgca cccggtcggc caggaaggtg tcgacgcccg
     8161 acttcgactt gtcgatcact gtggtgccgc cgctcttgag gatccaacgg accgagcccg
     8221 ccgagccgtt gccgaccttg atctggaagt cgacgtccgt ccatttgtcg tgcagcggcg
     8281 ccaggtccgt acggccgacg agggtgtcgc tgtcgaagag cttcagctcg atggtctggg
     8341 cgccgttcac ccggcgcagc gactggacga cgatcgggga ggagccggag ccgggctgct
     8401 tcatctgcat gatgtgggtg aaggaggtcg tggccttcaa cgagctcggg atgtacatgg
     8461 agtaggtgat ccgccaggtc tggccctggg tccacttcag atagctgctt ccggaggtgc
     8521 gcaggcccgt gacctcctgg cgctggcggt cggtggaggt gtcccggtcg gacatgtgca
     8581 tgttgaagcg ccagttgtcg ccggtggcgt agatgtgcgg ctgcccgccc gggtgggagt
     8641 cggcgcggtc gtcctcgatg gtctcgaagg cgcgcatgcc gtcggagctc gcggacggcg
     8701 accacttcag ctgccaggac gcggcccgtg cgtgcgtcgc ggcgggcaac cctacggcgg
     8761 cggaggccac gccgcccagc gcggcgccca gcaggaccct tctggatgtg cccatgacac
     8821 taatcactcc tcagctgttc gttcatgatc aggaaggctc cgaggccgtg gaagtcgttg
     8881 gtggcccggg tgcgggcgat gtagtacgcg tagtcgccga cgttggtgcc gatggagatg
     8941 tcggtgaggt cggtgcgtcc gtccgcgccg agggagacct tcttcaggac gccctggtag
     9001 ccgcgttcgg cgacggtcgc gtagtgccgg tcgaggtagc cctgctgggc gcctcgggac
     9061 agggcgtagg tgaacatgct ggagcaggag gtctcggtcc agttgtcggc gcggtcgccc
     9121 ttgtcgatga cctggaacca gcggccggtg gaggggtcct gggtgcgctc caggcctttg
     9181 gcgagcttgc gcaggatgcg cagcagggct tggcggcggg ggtggtcgcc cgggatggcg
     9241 tccaggacgt tcaccatcgc catcgagtac cagcccacgg cacggcacca gtgctcgggg
     9301 gcgaggccgg tggcctggtc ggaccaggtg gcggtgcggg actcgtcgta ggcgtgccgg
     9361 agaaggccat tgcctacttg cagatggctg ccgtacaggt acagctgctt ggccgcctcg
     9421 tcgttcgcgt acgacgagtc gtcgaactcc ttgccgtact cgaccaggaa cgggttgacc
     9481 atgtagaccc cgtcggccca caactgatgt gcgcggctgg cggtgtcggc gtgccagaag
     9541 ccgccgtcct cggtgcgcgg gtaggtgtcg aggcgttcgc ggatcttgcg ggccgcgatg
     9601 cggtagcggt cgtcgccggt ctcgtggtgc aggatcgtca gcagccgccc ggcctgcatg
     9661 ctgtcgaggt tgttgaagct ctggctcatg gagccgtccg cggccacgaa ccggtcgacg
     9721 tagctcttga tgtacgccag gtactgcggg ttgtgggtgc ggcggaagac caggtactgg
     9781 ccgtagaggt agaggccgac cgggtacgac cagccgccga tggtggtcgg tgtgtagcgg
     9841 gccgtggtgg agtcgaccat ggcgacggac cagtcggcgg tggtgacggg ggctgtgacc
     9901 ggcatcgcca tggctggtgc gggttcggcc gcggccgtgg ggacggcggt gagggtcgcg
     9961 gcggcgagca cggtcgtcgt cagcagcgcg tgcaggcgtc tcatggtgct ccttcgcggt
    10021 aggcgtggac gggggttgcg gccgggcggg ggctgtcgac caggtcgcgg atgagggcgt
    10081 ggtcgggtga gagccggcag gccgggtcgg tgcgggtggc gtcgccggtg agtgcgaacg
    10141 cctggcagcg gcagccgccg tggtcggtgg agctgaggcc gcagcttcgg caggggtcgc
    10201 gcatccagga gtcgccgcgg taggcgttga acgccctcga ctcccgccag atccagtcga
    10261 gttgacggtc cctcacattg ggtgggtcga ggccggggag ggcggccgcg gcggggcagg
    10321 gcaggacggt gccgtcaggg gcgacggtga gggagagggc gccccagccg cccatgcagg
    10381 gtttggcgac gccgtcgatg tggtcggggg tgacccagat caactccggt gcggggcccg
    10441 ggcgttcgcg ccagcgggtg agtgtggtgc gggcgcggtc cacctggttc cgggtgggca
    10501 gcagggtggc gcggttgcgc agggcccagc cgtggaactg ggtgtgcgcg agctcgattc
    10561 ggtcggcgcc ccaggccacg cccagggcga tcaggtcgtc gagggcgtcg atgttggtgc
    10621 ggtgcaggac gatgttcagg ccgaacggca gcccggcggc acggatcagc cgggcggcgc
    10681 gttccttggc ggcgaacgaa cgggcgcccg cgatgcggtc ggaggcgtcg gggtcggcgt
    10741 gctgcacgga cagctggacg ctgtgcagcc cggccgcgac cagctcgtcg agccgccgct
    10801 cccccagtcc gacgccgctg gtgacgagct gggtgtagag gcccgcgcgt tcggctgcgg
    10861 cgacgatgtc cggcaggtct cgccgcaaca gtggctcgcc gcccgacaga tgggtctgta
    10921 cgacgcccag gtcagcggcc tgccggaaca ctccggccca ttccccggcg gtcagctctg
    10981 ttgaccgacc gaccagttcg acggggttgg agcagtaccc gcagcgcagc gggcagcgat
    11041 gggtgagctc cgcgagcagg gcccacggcg ggtcgaccgt catcgcagcc agccctcctt
    11101 ccgcaacgtc tcaaggaact ccggcacttc gccggcgacc ggggcgccag ggaagcgcgc
    11161 ggccagctcg gcgacgatgt cctccacctc gcgactgccg tcgcacagcc gcagtacgcc
    11221 gcccgcgttg ccgtgcagca cgaccacccg ctcgggcagc agcaacaggt cggtgccgcg
    11281 cacccggtcg tgacgcagga cgacggagcg ggcgagggtg gggcgccagg tcatgggggg
    11341 tcacctccgg tggctccggc tcggcttgca gctcgggctc cgtcttggcc gccgcacgcc
    11401 gcgccatggc gtacgccgac cgcacgcgag tgggcagcac cccaggtcat gggccacctc
    11461 cgtccaccga gtcatgccgc agggccgccg cacgggcgag aacaggacgc cggttcatgg
    11521 cccgccccca tccaccgcgt ccagcaacgc ccaaagcaca tcgcacttga accccagcgc
    11581 acccaccgcc cgctcctgct gttcccgggt gcgggcctgg tccaggacca gggcgagggc
    11641 ctcctcgccg tcccgggcgc cctggtcgac ccgggtgcgg aagtaggcga ggccggccgg
    11701 gtcgatccag gggtagtggg tctcgaaggc gtcgatgcgg gtgcgcatca ggtcgggtgc
    11761 ggacagttcg gtcagggacg cggcgacggc ctcgacgacg gggctgagcc ggcagaagtt
    11821 gacgtagccg tcgaccgcga gccgcacccc ggggagcacc cgggaggcgt cccagagttc
    11881 ctcgcggtcc aggccggccg cctcgccgag gcgcagccag cgctcgatgc cgccctcgcc
    11941 ctcggcggtg ccgtcgtggt cgcggatgcg gcgcagccag gcccggcgcg gcgcgggacg
    12001 ctccagtttg gcgaggatca gggcgtcctt gacggggatg tggcgctggt agtggaagcg
    12061 gttggcgatc cagcggcgca gttcggcggg cgtcaactcg cctttgtgca tacggaggtt
    12121 gaaggggtgc cggtcgtggt agcgggccgc ggtgacggcg cgcagccgcc cagtgaactc
    12181 ggtggtcgtc cagggggctg cggcgccgtg cgcgtgcacg cgagtcgcgg tcacgatgct
    12241 ctcgcggtgc ggccggtcag cggtcggcga gggcgtaggc ggtcacttcg agcgcggtgt
    12301 ccacgacggt gtagccgggg ctacgccaga cgctttcctc cgatgtttcc tgaatgatct
    12361 gttccgtcgc gagggccggg agggtacgga gcagcttctc gtccatgtgc gcatacctgc
    12421 tttcctgagg aagtgggggt ctcagagccc agacaggcgg ctgccgttca catgcgtgca
    12481 ccgagttcat cgacacgttc ggtggcggga ttcagagtcg cggcatgacg gcccacggtc
    12541 aatggtccgg accgataacg tcggatgcgt ttccggccaa tctcaccgac gttccgctga
    12601 ctcgccagtc agttgccgcg atttccccgg cggattcggc ggtcaggaat gcatcacgcc
    12661 tcgtgatcgt tgacgatatg agtaccacct gacgacaacc gtaaggatcg agagctcgtg
    12721 agcagcaagg tccccccgat caccctcaac aacggcgtcg agatgcccca gctgggcttc
    12781 ggcgtctggc aggtgccgga cggcgaggcg gaggaggcgg tcggcaccgc gctggaggcc
    12841 gggtaccgca gcatcgacac agcggcgatc tacggcaatg aggagggcac cggcaaggcc
    12901 atcgccacct ccggcctccc ccgcgaggac atcttcgtca ccaccaagct ctggaacggc
    12961 gatcagggct acgactccac gctgcgcgcc ttcgacgtgt cgctcggcaa gctcggcctg
    13021 gactacgtcg acctgtatct catccactgg ccggctccgt cgcgcgacaa gtacgtcgac
    13081 acctacaagg cgttcgagaa gctgcacgcc gacggccgta tccgcgcgat cggtgtctcc
    13141 aacttccttc cggagcacct ggagcggctg ctcgacgaga cgtcggtcgt ccccgccgtc
    13201 aaccagatcg agctgcaccc gcaccttcag cagcacacct cgcgcgcgtt ccacgccgag
    13261 cggggcatcg ccaccgaggc ctggtcgccg ctgggttcgg gcaagggcct gctggaggtc
    13321 ccggcgatcg tcgccatcgc acagaagcac ggccgcaccc cggcccagat cgtgctgcgc
    13381 tggcacctcc agatcggcaa catcgtgatc ccgaagtccg tgacgccgtc ccggatcaag
    13441 gagaacatcg aggtcttcga cttcagcctg gacgacgagg acctggcggc gatcagcgcg
    13501 ctgaacgagg accgccggat cggcagcgac ccggcgaccg tcagctgaga ccacccgacc
    13561 gctcgcccgc gactgctcgc ccgccgctcg accgtccgag cggcgggcga gcgcgtaccg
    13621 gcccttagcg ggatgccgtc ggcgaccgcg acggctcagt cgccgcgcac atcggtgaag
    13681 acgacctcga actcctccag cccggtcacc gccacatgcg ccttggccgc accctcgtgc
    13741 cgggccgccg cctgacccgc gcgggacgcc gccagcgacg actggtcgac gaagatcacc
    13801 ccgaccaagc cgcgtccgcg cgcccggtcg accagcaggg acgccctggc cagccccgga
    13861 agggtctcga gcctgggcac cacggtggcc ctgaatgtgt cggcgagcag atccgtgtcc
    13921 ctggggtcga actccagcct ggagacacgc agcccgccgc ccgcctgcgg ctgccgcgcc
    13981 tggtggaaca ccagcgcctc gtagttgtcg accgagaccg tccccagaaa cggctccagc
    14041 atcgacaccc gccgctcacg cagcacttcg tcactgttct gccgggcctg ctccgactcc
    14101 caccaactcg ccgcgaggag tttgccgagc gtccggtcca cgaagacgct cgccccgcgg
    14161 taccccggac ggtcctccag caggtcccgc ccctcggtgt tcagggccct gatggccgtg
    14221 tcgatcttcg tgggatcgcc ggtcgtgtag atggcgcgta cgaacatgac acctcccggg
    14281 aatccgggct gacatccgaa atcttcggta tgtccagtct tctactgggc gcatgacgtc
    14341 gcaatcagca caccgggccc gagatcgcat cccgagggct tgacggggac acgcaaagag
    14401 gttcacgctg cacgcgatcc agtcaggaaa ctttcctaac agattcctca cgaaagggtc
    14461 ccccccacag tgcgtatccg aacactgacc ctcatcgcgg cctccggcgc cgcgctgctc
    14521 gccgccggtc tgcttcccac cagcgcctcc ggccacccgc aaccgccgtc cctccaggag
    14581 ggctcggtca gtgcggccga cctgctcgcg aaggtgacgt cctgttccca gatctccaac
    14641 ggcaagtacc gcaccgacga ggagacctcg gccaccgtcc cggtgtgcgg caagaacggc
    14701 gccgtgttct ggaaggccga catggacatc gactgcgacg gccagcgcac cgccaagtgc
    14761 aacgcggaca ccgatccctg gtaccagccc gacaccgcct tccaccagtc caacggcaag
    14821 ccgctgcgcg ccgacaccct gccctatgtc gtcgtcccca gcgtcagcgg cacctgggac
    14881 tactccggcg ccggcatcaa gggcggcggc gtggtggccg tgatccacga caaccaggtc
    14941 gtctacgccg tcgtcggcga cacgggcccc cagcggatca tcggcgaggc ctcgtacgcc
    15001 accgccgagc ggctcggcat agaccccgac ccggagaacg gcggcaccga ctccggtgtg
    15061 acctacatcc tcttcaagaa ctccaaggtc tcgcccatcg agaaccacgg cgcggcggtc
    15121 acgctgggcg agaagctggc gaaggagttc atccagaaca actaacagct gcggtacgtc
    15181 agttgggctg cccgagcggc cgtacgacga cggtgttgac gtccacgccg tcgggctgcc
    15241 ggacggccca caccaccgag tcggcgatct ggtcggcggt cagcagatgc ccgggcggca
    15301 ggctgccgta gctgtcccag aagggtgtct cgacccggcc gggcgcgatg tgggtgacgc
    15361 ccacgcccca gtcggtcacc tgtcgccggg tgttctcggc gagccccgtc acggcccact
    15421 tggtcgcccc atagatgttg ccgggcccgt tcacgaaccc ggcgacactg ccgaccagca
    15481 cgatccggcc gcgggtctcc ttgagggcgt cgatggaggc gcggatgagc agggccgggc
    15541 cgaggacgtt ggtcagcacc atctcggtcc agccggacgg gtcaccctcg gcgaccgtgt
    15601 cgtgggtcgc gaaccccgcg ttggcgacca ccgtgtccag tcggccgaac gccttgagcg
    15661 tcgcgtcgac cgccacctgg acgtcggtgt actcggcggc gttcccgacg atggccaaca
    15721 aaccttccgg ttccccgagt tcctcggcga aggcccgcaa ccgcgcctca ccccgaccgg
    15781 tgacggtgac ccggtgcccg gcgtccagca gttgccgcgc gacggcggcg ccgatgccgc
    15841 tgccgccgcc ggtgatgagc gcgaccggag agtcgttcat gaaggttccc cctgtatccc
    15901 ggtgtcccga tatcccggtg tcccgattcg gacgacgggg attccatcac ttggagaact
    15961 ctcgaagtca aggcctctca cccgggctag gtcacccggg cccggtcacc tggtccggac
    16021 cgccgtgtac accgtctgcg ccgccaggac gaacagatcg gggcgatggt ggacgctcgc
    16081 cttgtcctcc gggtcgagga ggcggtcgag ggtcgcgcgg tcgtcggcgt cgaggcgctc
    16141 ggcgacgccc tcccggatgc gggtgaggac ggcggcggcg taggcccggg cgcggtccgt
    16201 ggtgggggcg ggcaggtcga gcaggaaggt gcgggtgccg gagggcctca ggccggcggc
    16261 ggtcatcagc gcgggccagt cctcggtctc ggcgacggag cggggcaggt cggcgcgcat
    16321 ctgcgcgaac cactccgcct ccagtgcgtc gagccgcgcg tggagcccgg gccgcccgaa
    16381 cccgatgtcc cggggcagga accgcgtggg cagcccaccc tcctggaggg ccagggtgcc
    16441 gccgtacgcg agccggtccg cgaacgcggc gagggcggcg cgctgatcgc cgaggtggtg
    16501 caggctgcgg ctggcccaca gcagatcggc cgggtagtcc aagtcgtcga ggatttccgg
    16561 gagttcaccg gcgagggtgc cgaagcggtc ggcgaccccg agccgttcgg cacgcgcccg
    16621 ggcccgctcc aggagcggtt cggatccgtc gacggcgacg atgcgggcgc cggggaaggt
    16681 gtcggcgagc agacaggcga cgacgcccgg gccactgccc gcgtcgacga ccagccccgg
    16741 ctcggtctgc cgcttggcga gccaggccat ggcgtgctcg tacaggggcg tgaacagttc
    16801 cgcctgcgcc tccagcagcg gagccatctc gccccagtcg atgtcggcgt ggtcgtggtg
    16861 gtggtgaccg gcgtggtggt caccgtggtc gccgtggtgg ttgtgcgcca tgctcgtcag
    16921 cctctccctc tggtgacgcc agcgtgcgcc gacgcaccgt cgcggggcca ctgtccttgc
    16981 cgtaacggca aaagcgaggc aaaaaaatcg gatgcggccg acgggtccga gcacccacga
    17041 tggtccgatg gacgacgaga tggtggagcg cttcctccgc gacgggttcg tgaagatcga
    17101 gggcgccttt ccgcctcgtg tcgccgagca ctgcgcgcga ttgctgtggc gggagacggg
    17161 atacgacgca caggacccgg cgacctggaa ggaccccgtg cactgggtgt acgacatggc
    17221 gcagggcccc ttcgcggccg ccgccaacac acccgccctg catgaggcct tcgatctgct
    17281 ggtgggcgag gaccgctggc agtcgcgcta ttcgctgggc agcttcccgc tgcggttccc
    17341 gcacgaggag gaaccggacg acgcgggctg gcacatcgag gccagctatg tgcccgaggg
    17401 cgccgagcac ccgcacacga atctggcctc gaaggagcgc gcgctgctga tgctgttcct
    17461 gttcagcgag gtcaccgagg cggacgcccc gacccgcatc agggtcggct cacatctcga
    17521 cgtaccgaag gtcctggagc cgtacggcga gaagggcgcc tccttcctgg agctcggccc
    17581 gaaggtcgcc gaggcctcgg cccaccgccc gctcgcccac gccaccggac gccccggcga
    17641 cgtctacctc tgccacccct tcctggtcca cgccgcccag ccccaccacg gcacccgccc
    17701 gcgcttcatg gcccagccgc ccctgcacac gtcggtacca ctggagctgg agcgaccgga
    17761 cggcaactac tcagcggtgg agttcgcaat ccgccggggc ttggcccaag agatctgacc
    17821 aaccccggcg aactacgacg ccctaagggg cgcggggctg tatccgattt gcggctccgc
    17881 cgcgtgggcg cgaccagcca cagcgaaccc gcagccgccg tcactcctct acgacaacgg
    17941 cggatacgcg ttctgcatca actgctggaa ctgcgcagag aaccagtgcc ccgacagcgg
    18001 agcgttcggc agcgcaccgg acatgttgtt gccattgcgc ggattacccg tgtacgtcgg
    18061 atcgcacatc cggtcgaagc ccttgccctc gtcgttcggg atctccgagc tggcgccgtc
    18121 ggactcaccc ggaggcttga tccagacgta ggcgtcgatg cccgccgccg gggcggcctg
    18181 cggccgctcg ccgagcccgg cccccgactg gttgcaccag ttgccgacgt ggatgcgccg
    18241 gtcgtagcgc ccgccgttga cataggtgtc gacgtcggtc gtggcccccg gaccggcggg
    18301 ccgggcagag ccaccccacc cgttccgcga tgtgtcgatc agcatgccga taccggagtt
    18361 gaagccggtg gtcaccagct gctggcggaa ggcctgcgcg aaggacagct cgtcggtgta
    18421 ccggttccag tcgacccact tcgactcacg gacggacttg ccgccgacgg agtcgttgat
    18481 ggtgaagttg ttctccttca gcgcgctgta gttcgccgtg ttggcgatga acccgtgcac
    18541 gtcgttcatg gtggcgccct cggaggtggc cgcctccttc atcaccgtgg cgctgggggc
    18601 gaagttgtcg tcccagccga tccagccgtg gtggccggcg tcgatgtagt tgtagacgtt
    18661 ggccacgtca ccgagcttgt tgagggcgta gccgacgccc ttctggtagt tgccgttggc
    18721 cttcatcaca tcgcactggg gcgtggcggt gggacggctg ccggtgttgg tgacgaggtt
    18781 gggcagggag tcgatctcga tcgtggtgac gatccgcagc gcggcgtact tggggtcggc
    18841 gaggatcgcg gcgatcgggt cgatgtactc ggtcttgtac cggccgagct cggtcgggcc
    18901 gagctcgccg ttggaggcga gggcggcgca gtcgcggccc ggcaggttgt agatgaccag
    18961 ctggacgacg agttcgccgg agcccttctg ggtcagggcc tcgtcgaggt ggtcgcgcag
    19021 gcccatgccg ccgttgacgc cgttgatcgc ggcgatccgg tccagccaga cgccggtcgg
    19081 ctggctggcg atccggcttc cgcccggctc ggcggcggcc ttcgcggacc attccgggtt
    19141 cacatacacc ttggcgccgg agtacgggtt gtcgaccttg gggccggtgg ggtcggggtc
    19201 cggcggatcg gtggggccgc caccgccgtc gtcgacgttg caggtcacgc cgtcgagggt
    19261 gaaggtggcg gggatggcgt tgctgccgct gtaagtgccc tggaagccga agctgaccga
    19321 acctccggtc gccagcgtgg cgttgtaggt ctcattggcc gcggtgacat cggcgccgct
    19381 ctggccgatc ttcgcgttcc agccgctggt gaccttctgg ttgccggcgt acgaccactt
    19441 caccgaccag ttcgacttgg cggcgccctg gttggtgacg gtgacggcgg cggtgaagcc
    19501 ggtgtcccac tggttctgca ccttgtagtc gacggtgcag ggcacggcgg ccgtgccgat
    19561 tccgccgggg tccgcggcga gcgcggttcc cgaggccccg gcgaccagcg ccagggcggc
    19621 gagcatcgct gttctggtac gactcatgag tgcgggttcc ttcttggttg cgggtgctga
    19681 cggttcgtcc gtgcagggcg cgcaagaggc aaggaggagg tgccgacgac ggctaaaagt
    19741 actgaacgtg aggggtgtcg catgagcgac tccttgcagc tccggcgcgt cgtgacggac
    19801 gcgtcgactg atggaatcgc tcccactggt gcttttgaag ttagcgccaa gtgacggtaa
    19861 aggacagggg agttactgac ttttgctcaa ctgaactcat cgaatctttt cgactcttca
    19921 agcaccttga ccccttgcac ccccgtcccc actatgggag cgctcccact ggttcaagcc
    19981 ttgacttctc cgagccgcaa ggaggaacca gcacgtgcat cccccacgca gacgcagagc
    20041 cgtacgaagg ttctggacgg ccgcagtcgc ggccctcgct cttcccttga cgatgctggg
    20101 cacgggttcg acacccgcgc aggcagcggc ggttcagtgc agtgtcgact acaagaccaa
    20161 tgactggggc tccggcttca ccgcggagct gacgctcacc aaccgcggta cggacgtcat
    20221 cgacggctgg accctgacgt acggctacac gggcaaccag aagctcggca acggctggaa
    20281 cggcacctgg tcgcagtccg gtcagacggt caccgtgaag gatgccggcc acaacgggcg
    20341 gatcgccgcc ggtgccgcgg tctccaccgg tgcgcagttc acctacagcg gcagcaatgc
    20401 cgcgcccacg aacttcgcca tcaacggcac gagttgcacg ggcgcccacc aaccccccat
    20461 caccgtgctg accagcccgg cggcgggcgc cgtctactcg cagggcgacg ccgtcccgct
    20521 cgcggccacc gcggccgccg cggacaacgc gaccatcggc aaggtggagt tctacgacga
    20581 caccacgctg ctgggcaccg acaccacggc gccgtacgcg ctctcggtct ccagcttgac
    20641 cgtgggcagt cattcgctgc tggccaaggc gtacgacagc ctgggcgcat ccgcggagtc
    20701 cacaccggtc ggcgtcacgg tcgcctcggg tcccgccgtg gtggccacac cggcccaact
    20761 ccccatccag cagggcaagt cggcgaccta tgacgtgaag ctgtcaacgc agccttcggc
    20821 caacgtcacc gtctccaccg cccgggcgag cggcaacacg ggcctgtcgg tgaccggcgg
    20881 cgcctcgctc accttcacgc cctcgaactg gaacaccgcc cagaaggtca ccatcgcagc
    20941 cggcagctcc ggcaccggcg cggcgacctt cgagtcgacg gccggcgggc acgccaaggc
    21001 gtcggtgacg gtcacccaga tcgcggcgac gaaggcgtac gacgcccgct tcctggagct
    21061 gtacggcaag atcaccaacc cggcgaacgg ctacttctcg cccgagggca tcccctacca
    21121 ctcggtcgag acgctgatcg tcgaggcgcc ggaccacggt catgagacca cgtcggaggc
    21181 ctacagctac cttctctggc tgcaggcgat gtacggcaag gtcacgggcg actggtccaa
    21241 gttcaacggg gcctgggaca tcatggagaa gtacatgatc ccgacccacg ccgaccagcc
    21301 gacgaactcc ttctacaacg cctcgaagcc ggcgacgtac gcgcccgagc tggacacgcc
    21361 caacgagtac ccggcgaagc tcgactcgtc ggtctccgtc ggctcggacc ccatcgccgg
    21421 tgagctgaag agcgcgtacg gcaccgacga cgtctacggc atgcactggc tgcaggacgt
    21481 cgacaacgtc tacgggtacg gcaattcgcc gggcaagtgc gaggcggggc cgggtgacac
    21541 cgggccgtcg tacatcaaca ccttccagcg cggcgcgcag gaatcggtgt gggagacggt
    21601 gccgcagccg acgtgcgacc agttcaagta cggcggcagg aacggctacc tggacctctt
    21661 caccggtgac gcgtcgtacg ccaagcagtg gaagttcacc aacgccccgg acgccgacgc
    21721 ccgtgcggtg caggccgcgt actgggcgga caagtgggcc gacgagcagg gcaagggcgg
    21781 cgacatctcc gcgaccgtgt ccaaggctgc gaagatgggc gactatctgc ggtacgcgat
    21841 gtacgacaag tacttcaaga agatcggcag ttgcgtgggg ccgtccagct gcccggccgg
    21901 caccggcaag gacgcctcgc actatctgct ctcctggtac tacgcctggg gcggcgccac
    21961 cgacacctcg gcgggctggg cctggcgcat cggctccagc catacgcacg ggggttacca
    22021 gaacccgatg gcggcgtacg cgctgagctc gtacgcggat ctgaagccca agtcggcgac
    22081 ggggcaggcg gattgggcca agtccctgga gcggcagatc gagttctatc gctggctgca
    22141 gtccagcgag ggcgcgatcg cgggcggggc gaccaacagc tgggcgggcc ggtacgcgac
    22201 accgcccacc ggcaggtcga ccttctacgg catg
//
