LOCUS       NZ_BNAU01000008        21041 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence08, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000008
VERSION     NZ_BNAU01000008.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 345420)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 319569
            Orig. end                         :: 340610
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21041
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="3"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..21041
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21041
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:11041](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11041
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     gene            complement(1081..1575)
                     /locus_tag="IE290_RS30775"
                     /old_locus_tag="GCM10017786_62440"
     CDS             complement(1081..1575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422613.1"
                     /locus_tag="IE290_RS30775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62440"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_191248205.1"
                     /transl_table=11
                     /translation="MGGFRFVLPVLVCVAACSAPAPQPPPPPPAECAHYDAGPVDAALG
                     HRGFVLTLTNCGTATRAVSGYPDVQVLGPEGRGLDVPVERGTSYMAIDPGPGTFTLAPG
                     KSLVSVVSWANTVTDGEVLTGSALGVASRPGEAPQRLPVETDLGTTGEITVTAWAEELA
                     R"
     gene            complement(1586..2281)
                     /locus_tag="IE290_RS30780"
                     /old_locus_tag="GCM10017786_62450"
     CDS             complement(1586..2281)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422612.1"
                     /locus_tag="IE290_RS30780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62450"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_191248206.1"
                     /transl_table=11
                     /translation="MDITGSIALVTGANRGLGRVLATALLDRGAKTVYAGARDPRSITD
                     PRLTPVRLDVTDPASVAAAAELASDATLVVNNAGIGSNGSLLTAPDLDAARAVLETNFF
                     GPVHVSRAFAPVLGRNGGGALVNVLSVLSWLAPPITADYSAAKAAAWSFTNSARWELRG
                     QGTLVVGVHVGYLDTDMAAHVNGPKVAPEDLARQILDAVESGQEEVLGDELSRGVKAGL
                     AGPVAAFER"
     gene            complement(2283..3491)
                     /locus_tag="IE290_RS30785"
                     /old_locus_tag="GCM10017786_62460"
     CDS             complement(2283..3491)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0003985 - acetyl-CoA C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983343.1"
                     /locus_tag="IE290_RS30785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62460"
                     /product="thiolase family protein"
                     /protein_id="WP_191248207.1"
                     /transl_table=11
                     /translation="MRDAVIVEAVRTPVAKGKPTGAYAAVHPVELHAHVLRSAVERVPG
                     LDPAEIDDVIGGAVGQVGEQSGNTTRFAALAAGFPESVAGVTVDRQCGSSQQAISFAAQ
                     GIVAGAYDIVLASGVESMSHVPIGSSANVDGVRADVWGPSVDRRYPGGLIPQGVAAELI
                     ARKWNLSRTQLDEFAVTSHQRAAAAWRDGHFAGQVAPLKVTAADGTVTQLDADETIRPG
                     TTLEVLAGLRPAFAHDHWTERFGEIDWKVTAGNSSPVNDGAAALVLTTSEIARQRGWRP
                     RARIHTATVTGDDPVYMLTGIIPATAKVLARAGLSISDIDAFEVNEAFSSVVLAWLAET
                     GADPAKVNVDGGAIAIGHPLGASGARLATTLLGVLERTGGRFGLQTMCEAGGTANATII
                     ERL"
     gene            3607..4191
                     /locus_tag="IE290_RS30790"
                     /old_locus_tag="GCM10017786_62470"
     CDS             3607..4191
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422610.1"
                     /locus_tag="IE290_RS30790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62470"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_191248208.1"
                     /transl_table=11
                     /translation="MARTAAPGTRERILDVAGALFYTEGVRAVGMSRIIGEVGCGKNLL
                     YAHFPSKTDLVAAYLGRFRERRDRAEAQALREAGDDPGEQLVALVAEIAGRLRRPDFRG
                     CPFRNLLTEFPAGDELPERMAREYLAQTRELVGRLAGETGVPDREGLADRIWLIIDGLY
                     ASEFRERAAEVAPAMVREAITAARDARTPTV"
     gene            complement(4279..4692)
                     /locus_tag="IE290_RS30795"
                     /old_locus_tag="GCM10017786_62480"
     CDS             complement(4279..4692)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-133). E-value:
                     2.3e-15. Score: 49.2. Matches aSDomain:
                     nrpspksdomains_IE290_RS30795_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983339.1"
                     /locus_tag="IE290_RS30795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62480"
                     /product="SRPBCC family protein"
                     /protein_id="WP_191248209.1"
                     /transl_table=11
                     /translation="MTEFERERAMPAPAERVFTVAADVNRLDEWLPGVITVHPAEPEGL
                     DVDVHDPAGEYEAPGVLGARREQLRLEWGRRGSADYSGWLQVSSAEGGSSYATLHLSFH
                     GDQPANHGGQAAEDVERRLDESLDKLANLVSAG"
     aSDomain        complement(4294..4692)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS30795_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.30E-15"
                     /label="IE290_RS30795_Polyketide_cyc2.1"
                     /locus_tag="IE290_RS30795"
                     /protein_end="133"
                     /protein_start="0"
                     /score="49.2"
                     /tool="antismash"
                     /translation="MTEFERERAMPAPAERVFTVAADVNRLDEWLPGVITVHPAEPEGL
                     DVDVHDPAGEYEAPGVLGARREQLRLEWGRRGSADYSGWLQVSSAEGGSSYATLHLSFH
                     GDQPANHGGQAAEDVERRLDESLDKLANL"
     gene            complement(4689..5075)
                     /locus_tag="IE290_RS30800"
                     /old_locus_tag="GCM10017786_62490"
     CDS             complement(4689..5075)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422606.1"
                     /locus_tag="IE290_RS30800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62490"
                     /product="YchJ family protein"
                     /protein_id="WP_191248210.1"
                     /transl_table=11
                     /translation="MRCPCGLGETYENCCAPLHRRESAAPTAERLMRSRFSAFAVGEVD
                     YLLASWHPDTRPATIRLDPGQRWTRLEVLATTGGSPFHTHGTVEFRAHYRDAAGPGSLH
                     EDSEFTRVDGRWVYTGPRRVARGT"
     gene            5157..6020
                     /locus_tag="IE290_RS30805"
                     /old_locus_tag="GCM10017786_62500"
     CDS             5157..6020
                     /EC_number="4.1.2.61"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (20-235). E-value: 5.4e-48. Score:
                     155.4. Matches aSDomain:
                     nrpspksdomains_IE290_RS30805_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983337.1"
                     /locus_tag="IE290_RS30805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62500"
                     /product="p-hydroxycinnamoyl CoA hydratase/lyase"
                     /protein_id="WP_191248211.1"
                     /transl_table=11
                     /translation="MSTAVGNGRVRTEPWGDTVLVEFDEGIAWVTLNRPDKRNAMNPTL
                     NDEMVRVLDHLEGDDRCRVLVLTGAGESFSAGMDLKEYFREVDATGSTAVQIRVRRASA
                     EWQWKRLANWSKPTIAMVNGWCFGGAFTPLVACDLAFADEDAQFGLSEVNWGIPPGGVV
                     SRALAATVPQRDALYHIMTGEPFDGRRAAEMRLVNEAVPADRLRERTREVALKLASMNQ
                     VILHAAKTGYKIAQEMPWEQAEDYLYAKLDQSQFADKAGARAKGLTQFLDQKSYRPGLS
                     AFDPEK"
     aSDomain        5217..5861
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS30805_ECH.1"
                     /evalue="5.40E-48"
                     /label="IE290_RS30805_ECH.1"
                     /locus_tag="IE290_RS30805"
                     /protein_end="235"
                     /protein_start="20"
                     /score="155.4"
                     /tool="antismash"
                     /translation="VEFDEGIAWVTLNRPDKRNAMNPTLNDEMVRVLDHLEGDDRCRVL
                     VLTGAGESFSAGMDLKEYFREVDATGSTAVQIRVRRASAEWQWKRLANWSKPTIAMVNG
                     WCFGGAFTPLVACDLAFADEDAQFGLSEVNWGIPPGGVVSRALAATVPQRDALYHIMTG
                     EPFDGRRAAEMRLVNEAVPADRLRERTREVALKLASMNQVILHAAKTGYKIA"
     gene            6020..7495
                     /locus_tag="IE290_RS30810"
                     /old_locus_tag="GCM10017786_62510"
     CDS             6020..7495
                     /NRPS_PKS="Domain: AMP-binding (11-396). E-value: 3.3e-109.
                     Score: 357.1. Matches aSDomain:
                     nrpspksdomains_IE290_RS30810_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422604.1"
                     /locus_tag="IE290_RS30810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62510"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_191248212.1"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-115, bitscore:
                     379.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNQGLGSWPVRRARMSPHAIAVRHGGTELTYGELSRRVARLARG
                     LRGAGVRPGDRVAFLGPNHPAYLETLFACGQAGAVFVPLNFRLTVAELDHALADSGSTV
                     LIHTPEYADTVAALAGDRLLRVPAGELDAEGDEPLDLPVGLDDVCLLMYTSGSTGRPKA
                     AMLTHGNLTWNCVNVLVETDLATGERALVAAPLFHAAALGMVCLPTLLKGGTVILHSAF
                     DPGAVLSTVERDRVTLMFGVPTMYQAMAAHVRWDTTDLSSVRTLLCGGAPVPADLIRRY
                     LDRGLAFVQGYGMTEAAPGALVLDREHVEEKVGSAGVPSFFTDVRLAGPAGEPVRPGEK
                     GEIVVSGPNVMKGYWSRPDATAEVLRDGWFHSGDVATVDGDGYFHVVDRLKDVIISGGE
                     NIYPAEVENELYGYPGVEACAVIGVPDPRWGEVGKAVVVPAPGSRIDPGELLTWLRTRL
                     AGYKVPKSVEFTDALPTTGSGKIRKAEVRRRFG"
     aSDomain        6053..7207
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS30810_AMP-binding.1"
                     /evalue="3.30E-109"
                     /label="IE290_RS30810_AMP-binding.1"
                     /locus_tag="IE290_RS30810"
                     /protein_end="396"
                     /protein_start="11"
                     /score="357.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRARMSPHAIAVRHGGTELTYGELSRRVARLARGLRGAGVRPGDR
                     VAFLGPNHPAYLETLFACGQAGAVFVPLNFRLTVAELDHALADSGSTVLIHTPEYADTV
                     AALAGDRLLRVPAGELDAEGDEPLDLPVGLDDVCLLMYTSGSTGRPKAAMLTHGNLTWN
                     CVNVLVETDLATGERALVAAPLFHAAALGMVCLPTLLKGGTVILHSAFDPGAVLSTVER
                     DRVTLMFGVPTMYQAMAAHVRWDTTDLSSVRTLLCGGAPVPADLIRRYLDRGLAFVQGY
                     GMTEAAPGALVLDREHVEEKVGSAGVPSFFTDVRLAGPAGEPVRPGEKGEIVVSGPNVM
                     KGYWSRPDATAEVLRDGWFHSGDVATVDGDGYFHVVDRLKDVIIS"
     CDS_motif       6233..6274
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS30810_0001"
                     /evalue="1.80E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="IE290_RS30810"
                     /protein_end="85"
                     /protein_start="71"
                     /score="8.9"
                     /tool="antismash"
                     /translation="FACGQAGAVFVPLN"
     CDS_motif       6470..6523
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS30810_0002"
                     /evalue="1.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="IE290_RS30810"
                     /protein_end="168"
                     /protein_start="150"
                     /score="24.0"
                     /tool="antismash"
                     /translation="LMYTSGSTGRPKAAMLTH"
     CDS_motif       6815..6847
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS30810_0003"
                     /evalue="1.50E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="IE290_RS30810"
                     /protein_end="276"
                     /protein_start="265"
                     /score="3.2"
                     /tool="antismash"
                     /translation="LLCGGAPVPAD"
     CDS_motif       7028..7111
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS30810_0004"
                     /evalue="4.30E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="IE290_RS30810"
                     /protein_end="364"
                     /protein_start="336"
                     /score="31.9"
                     /tool="antismash"
                     /translation="PGEKGEIVVSGPNVMKGYWSRPDATAEV"
     gene            7537..8346
                     /locus_tag="IE290_RS30815"
                     /old_locus_tag="GCM10017786_62520"
     CDS             7537..8346
                     /NRPS_PKS="Domain: Abhydrolase_1 (18-125). E-value:
                     7.9e-19. Score: 60.1. Matches aSDomain:
                     nrpspksdomains_IE290_RS30815_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640676.1"
                     /locus_tag="IE290_RS30815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62520"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_308431393.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-15, bitscore: 52.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.7e-17, bitscore:
                     57.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIRARNAVTVAGRPGGQPMLFAHGFGCDQAMWRLITPAFEPDYQ
                     LVLFDHVGAGESDLGAWRPERYWTLDGYADDVLEICAELDLEDVVFVGHSVSSMIGVLA
                     AAREPARFAGLVMVCPSPCYIDDDGYTGGFSRADIDELLESLDSNYLGWSAAMAPVIMG
                     NPDRPALGAELTNSFCRTDPLIAREFARVTFLSDNRDDLARVTVPSLVLQSRHDAIAPL
                     PVGQYVHDRLPDSELVVLEVNGHCPHLSDPDLTTAAIGAFLTGRGTR"
     aSDomain        7591..7911
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS30815_Abhydrolase_1.1"
                     /evalue="7.90E-19"
                     /label="IE290_RS30815_Abhydrolase_1.1"
                     /locus_tag="IE290_RS30815"
                     /protein_end="125"
                     /protein_start="18"
                     /score="60.1"
                     /tool="antismash"
                     /translation="PMLFAHGFGCDQAMWRLITPAFEPDYQLVLFDHVGAGESDLGAWR
                     PERYWTLDGYADDVLEICAELDLEDVVFVGHSVSSMIGVLAAAREPARFAGLVMVCPSP
                     CYI"
     gene            8343..9512
                     /locus_tag="IE290_RS30820"
                     /old_locus_tag="GCM10017786_62530"
     CDS             8343..9512
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422602.1"
                     /locus_tag="IE290_RS30820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62530"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_191248213.1"
                     /transl_table=11
                     /translation="MTEPEAPALTGADAEDLWDNAPCGYLSARPDGTIVRVNATLLGWL
                     GYRAGELVGRRFSDLLTAGGRLYHETHYAPLLRMQSEVREIALDLVAADGSRLPVLVNS
                     TLRAGPDGVTGIRTTVFDARNRRAYERELLRARQEADTERERLARLSRTLQETLLPPGL
                     PEVPGLRAAGYYRAAPTQMIGGDFYDLFPLSADRWAFFIGDVCGKGPEAAVLTSLARYT
                     LRAAAARESDPRAVLHTLNAVLLQDYRAPAGRFCTVLFGLIEPDGDGFRVELAGGGHPP
                     ALRIAADASVRALDTPGGQLMGVLPDASVTAVGTRLGPGDALFLYTDGLTEARDRRGAL
                     VGEGRLACAAAGFAGLDADAIVDRLGQLLSELDDGVADDTAALVLTVPR"
     misc_feature    complement(9697..9708)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     gene            10001..11041
                     /locus_tag="IE290_RS30825"
                     /old_locus_tag="GCM10017786_62540"
     CDS             10001..11041
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_process="GO:0009820 - alkaloid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indole_PTase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005442043.1"
                     /locus_tag="IE290_RS30825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62540"
                     /product="tryptophan dimethylallyltransferase family
                     protein"
                     /protein_id="WP_191248214.1"
                     /sec_met_domain="indole_PTase (E-value: 4.2e-90, bitscore:
                     296.6, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGFPDHDGDPVDVLRELLGVAGARPLTEPPLWPSDVADDATPVE
                     FSVAFDAGGERAVRILGETIPENPGHVANIHAAKRFLTHMAQRFDLRLDRFEAVEDLFL
                     TERPQGKFTLWFSVILRPGRAPALKVYFNPQVRGQCAAPGVVAEGLRRLGLSDAYDTVA
                     EHALRRGAADQFSFFALDLDDGPLSRVKLYISHDSAESSTVEHAAQAVEGVDPLLVREF
                     LTNAGGGTGPYAGRPLISSYSFVEADSGRPGNYSLYLPIRDYVPDDAAAREQVLAHFAR
                     AGLPAAELDRAIAAVTDRPMAAGVGLIAHVSLRLGRFGTGTTVYLSSEAYAVNAPRTRV
                     GATATL"
     gene            11062..12435
                     /locus_tag="IE290_RS30830"
                     /old_locus_tag="GCM10017786_62550"
     CDS             11062..12435
                     /NRPS_PKS="Domain: Beta_elim_lyase (44-422). E-value:
                     6.4e-68. Score: 221.0. Matches aSDomain:
                     nrpspksdomains_IE290_RS30830_Beta_elim_lyase.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663269.1"
                     /locus_tag="IE290_RS30830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62550"
                     /product="tryptophanase"
                     /protein_id="WP_191248215.1"
                     /transl_table=11
                     /translation="MKSFPPYRVQVVKEIPITTRQEREEALARAGYNMFDLPANMVTID
                     LLTDSGTGAVSAAQEAGAAAADRSYAGSDSWFRFKSALEDLTSFPHLFPVHQGRAAERI
                     LFSTALKPGQISLSNTHFDTTRANVELAGAQARDLPCPEAADLDSRDPFKGNIDLGALE
                     ETLSGPDGSRVGQVLITITNNGGGGQPVSMANLKAVRALCDRFGVPFFLDAARFAENSW
                     LITQREEGYAGKTPKEVAQETFALADGFVASLKKDAIAPMGAAIGVRDENLAKQCEAIL
                     IATEGFRTYGGLGGHDLERVAQGLREVVDPNYLRNRAEETAHFARLINEAGVDIVQPAG
                     VHGLYLNAGRLLQHMPPHGFPGHALACELYLAGGIRCAELGSLYLGTFDDEHNLITPAP
                     FELVRLAIPRRTYTLAHLEYVADVLATIAKNPESVPEYRVTHAPQLLRHFNLKLRQVS"
     aSDomain        11194..12327
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS30830_Beta_elim_lyase.1"
                     /evalue="6.40E-68"
                     /label="IE290_RS30830_Beta_elim_lyase.1"
                     /locus_tag="IE290_RS30830"
                     /protein_end="422"
                     /protein_start="44"
                     /score="221.0"
                     /tool="antismash"
                     /translation="DLLTDSGTGAVSAAQEAGAAAADRSYAGSDSWFRFKSALEDLTSF
                     PHLFPVHQGRAAERILFSTALKPGQISLSNTHFDTTRANVELAGAQARDLPCPEAADLD
                     SRDPFKGNIDLGALEETLSGPDGSRVGQVLITITNNGGGGQPVSMANLKAVRALCDRFG
                     VPFFLDAARFAENSWLITQREEGYAGKTPKEVAQETFALADGFVASLKKDAIAPMGAAI
                     GVRDENLAKQCEAILIATEGFRTYGGLGGHDLERVAQGLREVVDPNYLRNRAEETAHFA
                     RLINEAGVDIVQPAGVHGLYLNAGRLLQHMPPHGFPGHALACELYLAGGIRCAELGSLY
                     LGTFDDEHNLITPAPFELVRLAIPRRTYTLAHLEYVAD"
     gene            complement(12969..13571)
                     /locus_tag="IE290_RS30835"
                     /old_locus_tag="GCM10017786_62560"
     CDS             complement(12969..13571)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422599.1"
                     /locus_tag="IE290_RS30835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62560"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_191248216.1"
                     /transl_table=11
                     /translation="MASTSSEEGGVIPTPVKIVIAGGFGAGKTTMVASVSEIVPLSTEE
                     VMTEASTGVDDLTGVERKTTTTVALDFGRITISPQTVLYLFGTPGQDRFWFMWDELALG
                     AIGTVVLVDTRRLDSSFAAIDFFERRKIPFIVAVNCFEDADDYEEDEIRKALAIAPGVP
                     VMFFDARSRESSKLALIRLVRYAMSRLPAESAELARA"
     gene            complement(13552..13917)
                     /locus_tag="IE290_RS30840"
                     /old_locus_tag="GCM10017786_62570"
     CDS             complement(13552..13917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983332.1"
                     /locus_tag="IE290_RS30840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62570"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_017983332.1"
                     /transl_table=11
                     /translation="MADDQWYDEAAGPLIRPYAITRGRIPSVDIKLDVATQVMAIRGNH
                     DPIGLTPEHLTILELCQRPLSVAEIAVYVKVPLAVVKVLCSDLIERGAVIVRSPSQPAK
                     APDRELLQAVLDGLNKL"
     gene            complement(13917..14342)
                     /locus_tag="IE290_RS30845"
                     /old_locus_tag="GCM10017786_62580"
     CDS             complement(13917..14342)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983331.1"
                     /locus_tag="IE290_RS30845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62580"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_017983331.1"
                     /transl_table=11
                     /translation="MNENENSKVDLNWLLDDMVDRVVGAQHAVVLSADGLLMGKSANLS
                     KDDSDQLSAIASSLQSLAKGASKHFQRGPVLQTLIEMAEGYLFVCAAGQGACLAILAEE
                     TVDVEMIAYEMSRLVKRVGDYMTSAPRDAARFVPEHN"
     gene            complement(14364..16697)
                     /locus_tag="IE290_RS30850"
                     /old_locus_tag="GCM10017786_62590"
     CDS             complement(14364..16697)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020486714.1"
                     /locus_tag="IE290_RS30850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62590"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_229874828.1"
                     /transl_table=11
                     /translation="MWIAGSGYFLVDAIYVRTVASSVQDVSIPAVTALGAVQQERQLSL
                     VYLERPQVGLRDLQAQQQSIDKSLTSLRSALAEVKSLVPDEIGQRMNQMESSLDQLPVI
                     RAEINLRTISKEQVNDFYNRLLDTSTDLFDSQARLVPDAESTQGGMTSVDIFRASDQMS
                     RAASLASSAFASGQFAPADHLQFAQLVGSYRAQLAKIAGYMAPEAGQRYRELTSSDEWQ
                     RLAAAENSIITHGPGAFRENVGGLTVRENDWRDLTTQVSGRLINLTVEQSELASGAALD
                     KGNVNLWTVIIGSVAALLAAVASIWVAIRVSRTLVDRTLMTRLERLRTDSLELARTRLP
                     SIVNRLKEGESVDVSAELPRLDHGKDEIGQVAEAFNIAQLTAVQAAASEAKARSGVNNV
                     FLGIAHRNQGLVHRQLQILDRMESREENPEQLKGLFQLDHLATRARRTTENLIILGGKQ
                     PGRRWRKPVWLMDVLRAAVSETEHYSRVEVENVPQVAIIGSAVADTIHLVAELVDNATT
                     FSPPGSQVHMTSTLVARGVVVDVADQGLGMKDDVREWANRMMSEPPEFDAMALKADSSL
                     GLFVVARLAARLGLKVMFDSSRYGGTRATILIPSALLANGDQVAENADPEFRGAPATAG
                     PDSYEQEETGVPAGANGMGRHENNGAPEPARRVPAELPSGRHAEPEPEKAGETTGVRTI
                     SVFEPEPAPSPTPSPRPKRSRAPLPQREPQRNLVAQLRDDPESDATDYHEFSGRTRNTL
                     SAFHKGTRRGRDADAPEDPRATID"
     misc_feature    16917..16931
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.68"
                     /tool="antismash"
     misc_feature    complement(16920..16933)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.93"
                     /tool="antismash"
     misc_feature    17016..17034
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(17066..17077)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            complement(17146..18624)
                     /locus_tag="IE290_RS30855"
                     /old_locus_tag="GCM10017786_62600"
     CDS             complement(17146..18624)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005437911.1"
                     /locus_tag="IE290_RS30855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62600"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_191248218.1"
                     /transl_table=11
                     /translation="MTDYGHDLLFGAVLVPTTARPGEALELARVADRAGLDLVSVPDHP
                     YRPEFTEAWTTLSVIAARTERVRVFPNVANLPLRPPAMLARAVASLDVLSGGRAGLALG
                     AGAYWDAITAEGGPWHAPAEAVSALGEAIAVIRALWTPGGPAHLRGKRYGLDGAEPGPP
                     PREPAIWVGALGPRMLRLTGTLADGWLPSMTRIPPAGLPAANAIIDAAAAHADRDPAAI
                     RRLYNLSPPALGHPRDWPGRLAELALTHGVSAFLLPAEGPDLVRLFATEIAPAVRELVA
                     TARGGHSPSRTPLAPRATPDDSIRVSTERVWDEDTRPSAPEPDPRRRHTERERTAGRRL
                     VEVHDHLRAELARLRDLLTGVAAGTLEPGAARSHLHTLTLRQNNWTLGAYCESYCRVVS
                     VHHHREDSDVFPALRRSEPGLAPVLDRLEDEHHAIQALVDRVDAALVAFVGSDGDIAGL
                     HAALDVLTDALLSHLSYEERELTGPLGRLWGGDG"
     gene            complement(18621..20006)
                     /locus_tag="IE290_RS30860"
                     /old_locus_tag="GCM10017786_62610"
     CDS             complement(18621..20006)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422955.1"
                     /locus_tag="IE290_RS30860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62610"
                     /product="MFS transporter"
                     /protein_id="WP_191248219.1"
                     /transl_table=11
                     /translation="MTRTSAPFAALLIAVLSFSLLQTMPVPALPTLQAEFGRSTTTVSW
                     VLSAFLLTASVATGLLGRLGDMFGKRRVLVACLAVSGAGTLLAALAPSIGVLIAARAIQ
                     GVGAATFPLAFGIVRDEFPRERVPVAIGWISSTFGIGFGAGLVIPGLIVDALSWEWIFW
                     LMFAVIVAGIAAVTAFVRESPVRSPGRVDWAGALLLTGGLVALLLAISEGRVWGWGSAA
                     IIGLFAAAAVLLVVFALVERRLARPLIDIGLLGRPAVLTSNITALIIGFGMYGAFTLVP
                     LLVETPSRAGYGFGASVTEAGLFIIPMAVTMLFASPLAGRIGAQAGFKLPLVLACVVGA
                     AGFVVFAVAHGTRWPIYLGNGILGIGVGFAFASLANLVVGAVDPRQTGEATGVNTIMRT
                     IGGTFGAQIASTIVTGEVIAGTRFPVESGYTTAFVLSAIAMGVAALVALAGPGRLVPAV
                     ASR"
     gene            20061..20531
                     /locus_tag="IE290_RS30865"
                     /old_locus_tag="GCM10017786_62620"
     CDS             20061..20531
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983327.1"
                     /locus_tag="IE290_RS30865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_62620"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_191248220.1"
                     /transl_table=11
                     /translation="MEDRETRPPTLLALPSYLAGHVARIGHRGLVAALSEHDLRLPHFA
                     VLTGLSDFGPLAQHALADRLGLNRSHLVGYLDLLERRGFVRRERDPDDRRRQRAALTDS
                     GMRLVRRLQEVAHRSQEESLGALSTSERQTLVDLMRRVVVADDAARKAVVRD"
ORIGIN
        1 ggtgacgctg ccgctggcga ccccggtcag cgacgcgaaa gtcctcaccg gacggcagaa
       61 accgatgacc gaggtggcga tgctgttcgc cgagatcacc accgagaacg ggctggaggg
      121 cgtcgggttc agctactcga aacgggccgg cgggccgggc cagttcgcgc acgcccgcga
      181 gatcgcgccg gtgctgctcg gcgaggatcc cagcgacatc gccaagatct gggacaagct
      241 ggtgtgggcc ggtgcgtcgg tgggacgcag tggcttgccg gtgcaggcga tcgcggcgtt
      301 cgacgtggcg ctgtgggacc tcaaggcgaa gcgggccggg ctgccgctcg cgaaactgct
      361 gggcgcgcac cgggattcgg tgcgctgcta caacacttcc ggcgggttcc tgcactcgcc
      421 gatcgaggag gtggtcgacc gcgcggccgc ggccgtcgag cggggcatcg gcgggatcaa
      481 gatcaaggtg ggccacccgt cgcacgaggt cgacctggcc cgcgtgacgg cggtgcggga
      541 caagatcggc gacgtcccgc tgatggtcga cgcgaaccag cagtgggacc gcgccgcggc
      601 gcgccgcatg tgccgcgcgc tggagccgct ggacctggtg tggatcgagg agccgctgga
      661 cgcctacgac ttcgaggggc acgcccagct gtcggcggcg ttcgacaccc cgatcgcgac
      721 gggcgagatg ctcgcgagcg cgggggagca cgccgagctg atccgggccc gtggcgcgga
      781 catcgtgcag ccggacgcgc cgcgcgtcgg gggcatcacg cagttcctga aggtcatggc
      841 cctggccgac cacgcgcacc tggggctggc gccgcacttc gcgatggaga tccacatcca
      901 cctggcggct gcctatccgc gcgagccgtg ggtcgagcac ttcgaatggc tggacccgct
      961 gttcgacgag cacctggaaa tcgcggacgg ccgcatgcac ctgtccggac gccccggcct
     1021 gggcgtgacg atcagcgagc aggcccgagc ctggacggtg gcccgcgacg aggtgcacgc
     1081 ttagcgcgcc agctcctcgg cccaggcggt caccgtgatc tcacccgtcg tgccgaggtc
     1141 ggtctccacc ggcaggcgct gcggcgcctc cccgggcctg gaggcgacac cgagcgccga
     1201 gccggtcagc acctcgccgt cggtcaccgt gttcgcccag gacaccaccg agaccaggga
     1261 cttccccggt gccagcgtga aggtcccggg gccggggtcg atcgccatgt aggacgtgcc
     1321 ccgctccacc gggacgtcca gcccccggcc ctccgggccg aggacctgga cgtccgggta
     1381 gccggacacc gcgcgggtgg cggtcccgca gttggtgagc gtgagcacga accctcggtg
     1441 ccccagcgcc gcgtcgaccg ggcccgcgtc gtagtgggcg cactccgcgg gcggcggtgg
     1501 cggaggctgc ggcgcgggcg ccgaacacgc cgcgacgcac accagaacgg gcagcacgaa
     1561 ccggaatccc cccatgcggg ccaggttacc gctcgaacgc ggccaccggt ccggcgaggc
     1621 ccgccttcac cccgcggctc agctcgtcgc ccagcacctc ctcctgcccg ctctccaccg
     1681 cgtccaggat ctgccgcgcg aggtcctccg gcgccacctt cgggccgttc acgtgcgcgg
     1741 ccatgtcggt gtccaggtag cccacgtgca cgccgaccac cagcgtgccc tggccgcgca
     1801 gctcccaccg ggccgagttg gtgaacgacc acgcggccgc cttcgccgcg ctgtagtccg
     1861 cggtgatcgg cggcgcgagc caggacagca ccgacagcac gttgaccagc gcgcccccgc
     1921 cgttgcggcc gaggaccggt gcgaacgcgc gggacacgtg gaccgggccg aagaagttgg
     1981 tctccagcac cgcccgggcc gcgtccaggt ccggcgcggt gagcagcgaa ccgttgctgc
     2041 cgatgcccgc gttgttgacc accagcgtgg cgtcggaagc cagctccgcc gccgcggcga
     2101 ccgacgcggg atcggtgacg tcgagccgga ccggtgtcag gcggggatcg gtgatgctcc
     2161 gtggatcccg ggccccggcg tagacggttt tcgcgccgcg gtcgagcaag gcggtggcga
     2221 gcacgcggcc gaggccgcgg ttggcgcccg tcacgagcgc gatcgaaccg gtgatgtcca
     2281 cgtcagagcc tttcgatgat ggtggcgttg gccgtgccgc ccgcctcgca catggtctgc
     2341 agaccgaacc ggccgccggt gcgctccagc acgccgagca gggtggtggc cagccgcgcg
     2401 ccgctcgcgc ccagcgggtg gccgatggcg atcgcgcccc cgtcgacgtt gaccttcgcc
     2461 gggtcggcgc cggtctcggc gagccaggcg agcacgaccg aggagaacgc ctcgttcacc
     2521 tcgaacgcgt ctatgtctga aatggacagt ccggcgcggg cgagtacctt cgcggtggcc
     2581 gggatgatcc cggtcagcat gtagacggga tcgtcgccgg tgaccgtcgc ggtgtggatc
     2641 cgcgcccggg gccgccaccc gcgctgccgc gcgatctcgc tggtggtgag cacgagcgcg
     2701 gccgcgccgt cgttgaccgg gctggagttg cccgcggtca ccttccagtc gatctcgccg
     2761 aaccgctcgg tccagtggtc gtgcgcgaac gccggacgca acccggccag cacctcgagg
     2821 gtggtgccgg gccggatcgt ctcgtcggcg tcgagctggg tgaccgtgcc gtcggcggcg
     2881 gtcaccttca gcggcgcgac ctggccggcg aagtgcccgt cgcgccacgc ggcggccgcc
     2941 cgctggtggc tggtgacggc gaactcgtcg agctgggtgc gggacaggtt ccacttgcgg
     3001 gcgatcagct cggcggccac cccctgcggg atgagcccgc cggggtagcg ccggtcgacc
     3061 gacgggcccc agacgtcggc gcggacgccg tcgacgttgg ccgagctgcc gatcggcacg
     3121 tggctcatcg actcgacgcc ggaggcgagg acgatgtcgt aggcgccggc gacgatcccc
     3181 tgcgcggcga agctgatcgc ctgctggctg ctgccgcact gccggtcgac ggtgacgccg
     3241 gcgaccgact cggggaagcc cgcggccagc gccgcgaacc gggtggtgtt gccgctctgc
     3301 tcgccgacct ggccgacggc gccgccgatg acgtcgtcga tctcggccgg gtcgaggccc
     3361 ggcacgcgtt ccacggcgct gcgcagcacg tgcgcgtgca gctcgacggg gtgcaccgcg
     3421 gcgtacgcgc cggtcggctt gcccttggcg acgggggtgc ggacggcctc gacgatgacg
     3481 gcgtccctca ttggcgtgct cccttctggc ggaccgatcg gtcccggacc gatcggtccg
     3541 agcatgcgcc gctgatcaca cggctgtcaa cagcgggcgg accgatcggt ccgttatcct
     3601 cgacacatgg cacgcacggc agcaccggga acgcgcgagc ggatcctcga cgtcgcgggc
     3661 gcgctcttct acaccgaagg ggtccgcgcg gtcgggatga gccggatcat cggcgaggtc
     3721 ggctgcggga agaacctgct ctacgcgcac ttcccgagca agaccgacct ggtcgcggcc
     3781 tacctcggcc ggttccgcga gcgacgggac cgcgccgagg cgcaagcgct gcgcgaagcg
     3841 ggcgacgatc cgggcgagca gttggtggcg ctggtggccg agatcgccgg acggctgcgg
     3901 cggccggact tccgcggctg cccgttccgc aacctgctga ccgagttccc ggccggggac
     3961 gagctgccgg agcggatggc gcgcgagtac ctggcccaga cccgcgagct ggtcggacgc
     4021 ctggcggggg agaccggtgt gcccgaccgg gaggggctgg cggaccggat ctggctgatc
     4081 atcgacggcc tctacgcgag cgagttccgg gagcgcgccg cggaagtggc accggcgatg
     4141 gtccgggagg cgatcacggc cgcgcgggat gcccgcacgc cgaccgtata acgacctata
     4201 cccggcgcct caggagcgcg cggtggtcgc cggcctggtg tccgatgtgg agggcgtgca
     4261 ggtgctcaac ggcgacgttc accccgccga caccaggttc gccagcttgt ccagcgactc
     4321 gtccagtcgc cgttcgacgt cttcggccgc ctggccgccg tggttggccg gctggtcgcc
     4381 gtggaaggac aggtgcaggg tggcgtagct ggacccgccc tcggccgaag acacctgcag
     4441 ccacccgctg tagtccgcgc tgccgcggcg gccccactcc agccgcagct gctcgcggcg
     4501 cgcgcccagc accccgggcg cctcgtactc gccggccggg tcgtgcacgt ccacgtccaa
     4561 gccctccggc tcggccgggt ggacggtgat cacgccgggc agccactcgt cgagccggtt
     4621 cacgtcggcg gccacggtga acacccgctc cgccggggcc ggcatggcgc gttcgcgttc
     4681 gaactcggtc atgtcccgcg ggctacccgg cgcggcccgg tgtacaccca gcggccgtcc
     4741 acgcgggtga actcgctgtc ctcgtgcagc gaacccggcc ccgcggcgtc ccggtagtgg
     4801 gcgcggaact cgacggtccc gtgcgtgtgg aacgggctgc cgccggtggt ggcgagcacc
     4861 tccagccgcg tccaccgctg gcccgggtcg agccggatcg tggccgggcg cgtgtccggg
     4921 tgccagctgg cgagcaggta gtccacctcg ccgacggcga acgcgctgaa ccgcgagcgc
     4981 atcagccgct cggcggtcgg cgccgccgac tcgcggcggt gcagtggcgc gcagcagttc
     5041 tcgtacgtct cacccagtcc gcagggacac ctcatgcccg cggattgtcc tcgcttgacg
     5101 tgcgtcggcg gcgcctggta ctcctatatc agaactactg atatagagga gtcttgatga
     5161 gcacagcggt cggcaacggg cgggtccgga cggaaccctg gggcgacacg gttctggtgg
     5221 agttcgacga gggcatcgcc tgggtcacgc tcaaccggcc ggacaagcgc aacgccatga
     5281 accccacgct gaacgacgag atggtgcggg tgctcgacca cctggagggc gacgaccgct
     5341 gccgggtcct ggtcctcacc ggcgccggcg agtcgttctc ggcgggcatg gacctcaagg
     5401 agtacttccg cgaggtcgac gcgaccggca gcacggcggt gcagatccgg gtgcgccggg
     5461 ccagcgcgga gtggcagtgg aagcggctgg cgaactggag caagccgacg atcgcgatgg
     5521 tcaacggctg gtgcttcggc ggtgcgttca ccccgctggt ggcctgcgac ctggccttcg
     5581 ccgacgagga cgcccagttc gggctgtccg aggtcaactg gggcatcccg ccgggcggcg
     5641 tggtctcccg tgcgctcgcg gcgaccgtcc cgcagcgcga cgccctgtac cacatcatga
     5701 ccggcgagcc gttcgacggc cgtcgcgccg cggagatgcg gctggtcaac gaggcggtgc
     5761 cggccgaccg gctgcgagag cgcacccgcg aggtggcgct gaagctggcg tcgatgaacc
     5821 aggtgatcct gcacgcggcc aagaccgggt acaagatcgc ccaggagatg ccgtgggagc
     5881 aggccgagga ctacctctac gccaagctcg accagtcgca gttcgcggac aaggccggcg
     5941 cccgcgccaa gggcctgacg cagttcctcg accagaagtc ctaccgcccc ggcctgagcg
     6001 ccttcgaccc ggagaagtag tgcgcaacca gggcctgggc tcgtggccgg tgcgccgcgc
     6061 caggatgagc ccgcacgcga tcgccgtccg gcacgggggg acggagctga cctacggcga
     6121 gctgtcccgc cgcgtcgcgc ggctggcccg ggggctgcga ggcgccgggg tccgccccgg
     6181 cgaccgggtg gccttcctcg ggcccaacca cccggcctac ctggagaccc tgttcgcgtg
     6241 cgggcaggcc ggcgcggtgt tcgtgccgct gaacttccgg ctgaccgtgg cggaactgga
     6301 ccacgcgctg gccgactccg ggtcgacggt gctgatccac acgccggagt acgcggacac
     6361 ggtcgccgcg ctggccggcg accggctgct gcgcgtgccc gccggcgagc tggacgccga
     6421 aggcgacgag ccgctcgacc tgcccgtcgg cctggacgac gtgtgcctgc tgatgtacac
     6481 ctcgggcagc accggacggc ccaaggcggc gatgctcacc cacggcaacc tcacctggaa
     6541 ctgcgtcaac gtcctggtgg agaccgatct ggcgaccggc gagcgggccc tggtcgccgc
     6601 gccgctgttc cacgccgccg ccctgggcat ggtgtgcctg cccaccctgc tcaagggcgg
     6661 gacggtgatc ctgcactcgg cgttcgaccc cggtgcggtg ctgtccacag tggaacggga
     6721 ccgggtcacg ctgatgttcg gcgtgcccac gatgtaccag gcgatggccg cgcacgtccg
     6781 gtgggacacc accgacctgt ccagcgtgcg gaccctgctg tgcggcggcg cgccggtgcc
     6841 ggccgacctg atccgccggt acctcgaccg cggactggcc ttcgtgcagg gctacgggat
     6901 gaccgaggcc gcgccgggcg cgctggtcct ggaccgcgag cacgtcgagg agaaggtcgg
     6961 ctccgcgggc gtgccgtcgt tcttcaccga cgtccggctg gccggcccgg ccggggagcc
     7021 ggtgcggccc ggggagaagg gcgagatcgt ggtcagcggg ccgaacgtga tgaagggcta
     7081 ctggagccgc ccggacgcga cggcggaggt gctgcgcgac ggctggttcc actccggcga
     7141 cgtggcgacc gtggacggtg acggctactt ccacgtggtc gaccggctca aggacgtgat
     7201 catctcgggc ggcgagaaca tctacccggc cgaggtggag aacgagctgt acggctaccc
     7261 cggggtggag gcgtgcgcgg tgatcggggt gccggacccg cgctggggcg aggtgggcaa
     7321 ggcggtcgtc gtgcccgcac ccggcagccg gatcgacccc ggcgagctgc tgacctggct
     7381 gcgcacgcgc ctggccgggt acaaggtgcc caaatcggtc gagttcaccg atgcgctgcc
     7441 cacgaccggt tccggcaaga tccgcaaggc cgaggtccgc cgccggttcg gctgatcggg
     7501 cggccgtccc ggcgcggggc ggctacgctg gcggcggtgg acatccgggc gaggaacgcg
     7561 gtgaccgtgg ccggacggcc gggcgggcag ccgatgctgt tcgcccacgg tttcggctgc
     7621 gaccaggcga tgtggcggct gatcaccccc gccttcgagc cggactacca gctggtgctg
     7681 ttcgaccacg tcggcgcggg cgaatccgac ctgggcgcgt ggcggcccga gcgctactgg
     7741 acgctggacg gctacgccga cgacgtgctg gagatctgcg ccgagctgga cctcgaggac
     7801 gtggtgttcg tcggccattc ggtcagctcg atgatcggtg tgctggccgc ggcccgcgag
     7861 ccggcccgct tcgccggcct ggtcatggtg tgcccgtcgc cgtgctacat cgacgacgac
     7921 ggctacaccg gcggcttcag ccgggccgac atcgacgagc tgctggagtc cctggacagc
     7981 aactacctcg gctggtcggc ggcgatggcg ccggtcatca tgggcaaccc ggaccgcccc
     8041 gcgctcggcg cggagctgac caacagcttc tgccgcaccg acccgctcat cgcccgcgag
     8101 ttcgcgcgcg tcacgtttct gtccgacaac cgggacgacc tcgcgcgggt gaccgtgccc
     8161 agcctcgtgc tgcagagcag gcacgacgcg atcgcgccgc tgccggtcgg gcagtacgtg
     8221 cacgaccggc tgccggacag cgagctggtg gtgctggagg tcaacgggca ctgcccgcac
     8281 ctgagcgatc cggacctgac gacggcggcg atcggggcgt tcctgaccgg ccgcgggacg
     8341 cggtgaccga gccggaggca ccggcgctga ccggggccga cgccgaggac ctgtgggaca
     8401 acgcgccctg cgggtacctc tcggcccggc cggacgggac gatcgtgcgg gtcaatgcga
     8461 ccctgctcgg ctggctcggc taccgggcgg gcgagctggt cgggcgccgg ttcagcgacc
     8521 tgctcaccgc gggcgggcgg ctctaccacg agacgcacta cgcgccgctg ctgcggatgc
     8581 agtccgaggt gcgggagatc gccctcgacc tggtcgcggc cgacggctcg cggctgccgg
     8641 tgctggtcaa ctcgacgttg cgcgccggcc cggacggggt caccgggatc cggaccacgg
     8701 tgttcgacgc ccgcaaccgg cgggcctacg agcgcgagct gctccgggct cggcaggagg
     8761 ccgacaccga gcgcgagcgg ctggcccggt tgtcccggac cctccaggag accctgctgc
     8821 cgccgggcct gcccgaggtg cccgggctgc gcgccgccgg gtactaccgg gccgcgccga
     8881 cgcagatgat cgggggcgac ttctacgacc tgttcccgct gagcgcggac cggtgggcgt
     8941 tcttcatcgg cgacgtctgc ggcaagggcc ccgaggcggc cgtgctcacc tcgctcgcgc
     9001 gctacacgct ccgggcggcc gcggcgcgcg agtccgaccc gcgtgcggtg ctgcacacgc
     9061 tcaacgccgt gctgctgcag gactaccggg cacccgccgg ccgcttctgc accgtcctgt
     9121 tcggactgat cgaaccggac ggggacgggt tccgggtgga gctggccggt ggtgggcacc
     9181 cgcccgcgct gcggatcgcg gcggacgcct cggtgcgcgc cctggacacg ccgggcggcc
     9241 agctgatggg tgtgctgccg gacgcctccg tgacggctgt cggcacccgg ctcgggccgg
     9301 gggacgcgct gttcctctac accgacgggc tgaccgaggc ccgcgaccgg cgcggcgcgc
     9361 tcgtcggcga gggccggctg gcgtgcgcgg cggccgggtt cgccggcctg gacgcggacg
     9421 cgatcgtcga ccgactcggg cagctgttgt cggagctgga cgacggggtc gccgacgaca
     9481 cggccgcgct ggtgctcacc gtgccgcgct gaccgcgacc ggccgcccac caggcccgat
     9541 tgtggctcat cggggccggt cgtgacactc cgctgatcag gtgaacagtg ttctagacac
     9601 ccgaaggttt ccggctcccg ccgaacggcg gctcgcacgt tgctccggtc ggtcctttgt
     9661 ggacggcacg gcggaaagtg gcgcagatcg catccagaaa gcgttttcgc agttagcgcc
     9721 ggtgtgaacc ggttgctgcg aagcggttcc gggcgtgcga tcagcgaaaa accggtgtcg
     9781 tggcagcgaa ccaggatgac agcgtccggt agtgactgac cgtgcggcca agatcactcc
     9841 tccagcggta cgtctcgccg gaaagatgac gttatgttgg tcggcggtct gtaccccgcc
     9901 tagtcgagca gtcgctcgcc agaccgtcgg agtgagtgtg aacgtcgccc ctgtgaccct
     9961 attcgaccac gccagtagac agctcggaga actctgcagg gtggcaggct ttccggacca
    10021 cgacggcgat cccgtcgacg tcctgcggga actcctcggg gtcgcgggcg ctcgcccgct
    10081 gaccgagccc ccgctgtggc cttcggacgt cgccgacgac gcgacccccg tggagttctc
    10141 cgtcgcgttc gacgccggcg gcgagcgcgc cgtgcggatc ctcggtgaaa cgatcccgga
    10201 gaaccccggc cacgtggcga acatccatgc cgcgaagcgc tttctcaccc acatggcgca
    10261 acggttcgat ctccggctgg accggttcga agcggtcgaa gacctgttcc tcaccgagcg
    10321 gccgcagggg aagttcacgc tctggttctc ggtgatcctg cgtcccggcc gcgccccggc
    10381 gctcaaggtc tacttcaacc cgcaggtgcg cggacagtgc gcggcccccg gggtcgtcgc
    10441 ggaagggctg cggcgcctgg ggttgagcga cgcctacgac acggtcgccg agcacgcgct
    10501 gcggcgtggc gccgccgacc agttctcgtt cttcgcgctc gacctcgacg acggcccgct
    10561 gtcccgggtc aagctctaca tttcacacga ttcggcggaa tcgagcaccg tggagcacgc
    10621 ggcgcaggcg gtcgagggcg tggacccgtt gctggtgcgg gagttcctga ccaacgccgg
    10681 cggcggcacc ggcccgtacg ccgggcgccc gctgatctcc agctactcct tcgtggaggc
    10741 cgactcgggc cgccccggca actacagcct ctacctcccg atccgcgact acgtcccgga
    10801 cgacgcggcg gcgcgtgagc aggtgctcgc ccacttcgcg cgggccgggc tgcccgccgc
    10861 ggagctggac cgggcgatcg cggcggtcac cgaccgcccg atggccgcgg gggtgggcct
    10921 gatcgcgcac gtctccctgc gtctcggccg gttcggcacc ggaacgacgg tatatctttc
    10981 gtcggaggcc tacgccgtga acgcgccccg cacgcgggtc ggcgccacgg ccacgttgtg
    11041 aactgggagg aagaagtcag catgaagtcg ttcccgccgt accgggtcca ggttgtcaag
    11101 gagatcccga tcacgacccg gcaggagcgg gaggaggcgc tggcccgcgc cggctacaac
    11161 atgttcgatc tgccggcgaa catggtcacg atcgacctgc tgaccgactc cggcaccggc
    11221 gcggtgtcgg ccgcgcagga ggccggcgcc gcggcggccg accggtccta cgccggttcg
    11281 gactcgtggt tccggttcaa gtcggcgctg gaggacctga cgtcgttccc gcacctgttc
    11341 ccggtccacc agggccgggc ggcggagcgg atcctgttct ccaccgcgct gaagccgggg
    11401 cagatctcgc tgtccaacac gcatttcgac accacgcggg cgaacgtgga gctggccggc
    11461 gcgcaggcac gcgacctgcc gtgcccggag gcggccgacc tggacagccg ggatccgttc
    11521 aagggcaaca tcgacctcgg cgcgctcgag gaaacgctgt ccggcccgga tggttcccgc
    11581 gtcggccagg tgctcatcac gatcaccaac aacggcggcg gcgggcagcc ggtgtcgatg
    11641 gcgaacctga aggccgtgcg cgcgctgtgc gaccggttcg gggtgccgtt cttcctggac
    11701 gcggcgcggt tcgcggagaa ctcgtggctg atcacccagc gcgaggaggg ttacgcgggc
    11761 aagacgccga aggaggtcgc gcaggagacc ttcgccctcg ccgacggttt cgtcgccagc
    11821 ctgaagaagg acgcgatcgc gccgatgggc gcggcgatcg gcgtgcggga tgagaatctg
    11881 gccaagcagt gcgaggcgat cctcatcgcg accgagggtt tccgcaccta cggcggcctg
    11941 ggcgggcacg acctggagcg ggtggcgcag gggctgcggg aggtcgtgga cccgaactac
    12001 ctgcgcaacc gtgccgagga gaccgcgcac ttcgcccggc tgatcaacga ggccggggtg
    12061 gacatcgtgc agccggccgg ggtgcacggc ctgtacctca acgccgggcg gctgctgcag
    12121 cacatgccgc cgcacggctt ccccgggcac gcgctggcgt gcgagctgta cctggcgggc
    12181 ggcatccggt gcgccgaact gggctcgctg tacctgggca ccttcgacga cgagcacaac
    12241 ctgatcaccc cggcgccgtt cgagctggtc cggctggcca tcccgcggcg gacctacacg
    12301 ctcgcgcacc tggagtacgt ggccgacgtc ctggcgacga tcgcgaagaa cccggagtcg
    12361 gtgccggagt accgggtcac gcacgcgccg cagttgttgc ggcacttcaa cttgaagttg
    12421 cggcaggttt cgtagccgct acgcgggttt ttgcgctgcg cgcggctgga agcgccggct
    12481 tcgcttcgct acgccccgat tgaggccgcc gccccgattt ttcattgttt caacggccga
    12541 gcaggggttg tcaaggcggg aaagagtacc ttgacaaccc ctgatcggcc gcagaactgg
    12601 gctgtggatc gggagcgggg gagggctggt cggcaaggtg gttgcttttc gttgccggct
    12661 tgcggacagg cagccggcaa cgaaaaaaca accaccccac gagccacccc tctcccgcaa
    12721 cccgatcccc agccaaatcg gttgccgagc agtcgggtca aggtactctt tccagccttg
    12781 acgcgacttc tcggcaaccg aacaattgaa gatcgggttc gggaggggca gatccgggcg
    12841 tagcgaagcg aagccggcgc cttcagccgc gcgcagcgca accacgcgcg tagagcaaac
    12901 gcgcgtagcg caaaaaggcc accccctcac caagaagggg tggcctttcc acgtcccgga
    12961 ccgaaacctc aggcgcgcgc cagctccgcg gactcggcgg gcaaccggct catcgcgtac
    13021 cgcaccaacc ggatcagcgc cagcttgctc gactcccgcg accgcgcgtc gaagaacatc
    13081 accggcaccc cgggggcgat cgccagcgcc ttgcggatct cgtcctcttc gtagtcgtcc
    13141 gcgtcctcga agcagttgac cgccacgatg aacgggatct tgcgccgttc gaagaagtcg
    13201 atcgccgcga agctggagtc cagccgccgc gtgtcgacca gcaccacggt gccgatggcg
    13261 cccagcgcga gctcgtccca catgaaccag aaccggtcct gcccgggcgt gccgaacagg
    13321 tacagcacgg tctgcgggga gatggtgatg cggccgaagt ccagcgcgac cgtggtcgtg
    13381 gtcttgcgtt cgacaccggt gaggtcgtcg acgcccgtgc tggcctccgt catcacctcc
    13441 tcggtggaca gcgggacgat ctcgctcacc gacgcgacca tggtggtctt gccggcgccg
    13501 aaaccacccg cgatgacgat cttcaccggc gtcgggatga cgccgccttc ttcagagctt
    13561 gttgaggcca tcgagcaccg cctggagtag ttcgcgatcg ggggccttgg cgggctgcga
    13621 cggcgaacgg acgatcacgg cgccccgttc gatcagatcg ctgcacaaca ccttgaccac
    13681 ggcgaggggg accttgacgt acacggcaat ttcagcgacc gacaacggcc gctggcacaa
    13741 ctcgaggatc gtcaggtgtt ccggggtcaa cccgatcggg tcgtggttgc cccggatggc
    13801 catcacctgc gtcgccacgt cgagcttgat gtcgacggac gggatccggc cccgggtgat
    13861 ggcgtagggc cggatcagcg gtccggccgc ttcgtcgtac cactggtcgt ccgccatcag
    13921 ttgtgctccg gaacgaacct cgcggcatcc cggggagccg acgtcatgta gtcgccgacg
    13981 cgcttgacga ggcggctcat ctcgtaggcg atcatctcga cgtccaccgt ctcctcggcg
    14041 aggatcgcca ggcacgcgcc ctgaccggcc gcgcacacga agaggtagcc ctcggccatc
    14101 tcgatgaggg tctgcagcac cgggccgcgc tggaagtgct tgctggcgcc cttggcgagg
    14161 ctctgcaggc tggaggcgat cgccgacagc tggtcggagt cgtccttgga caggttcgcg
    14221 gacttgccca tgagcagccc gtcggccgag aggaccacgg cgtgctgcgc cccgacgaca
    14281 cggtcgacca tgtcgtcgag cagccagttc aggtcgacct tggagttctc gttctcgttc
    14341 atcgatgagg ttcgacttcc ctctcagtca atggtggccc gggggtcttc cggtgcgtct
    14401 gcgtcgcgcc cgcggcgggt tcccttgtgg aacgccgaga gcgtgttgcg ggtccgcccg
    14461 gagaactcgt ggtaatcggt ggcgtccgac tccgggtcgt cacggagctg ggcgacgagg
    14521 ttgcgctgcg gctcgcgctg cggcagcgga gcccgggagc gcttgggacg cggcgagggg
    14581 gtcggcgacg gcgcgggctc cggctcgaac accgagatcg tccgcacacc ggtggtctcg
    14641 cccgccttct ccggttccgg ctcggcgtgc cgtcccgagg ggagctccgc agggacccgc
    14701 cgagcgggct cgggggcgcc gttgttctcg tgtcgtccca taccgttcgc tccggccggc
    14761 acgccggtct cctcctgctc gtacgagtcg ggcccggcgg tcgccggggc gccgcggaac
    14821 tccggatcgg cgttctcggc gacctggtcg ccgttggcga gcagtgccga cgggatcagg
    14881 atcgtggcgc gggtgccacc gtagcgcgag gagtcgaaca tgaccttgag gccgagccgg
    14941 gccgcgagcc gggcgacgac gaaaaggccc aggctggagt cggctttcag ggccatcgcg
    15001 tcgaactcgg gcggttccga catcatccgg ttggcccatt cccggacgtc gtccttcatg
    15061 cccaggccct ggtcggccac gtccaccacg acgccgcgcg cgaccagcgt ggaggtcatg
    15121 tggacctgcg acccgggcgg ggagaacgtg gtggcgttgt cgaccagctc ggcgaccagg
    15181 tggatggtgt cggccaccgc ggacccgatg atcgcgacct gcgggacgtt ctccacctcg
    15241 acgcgcgagt agtgctcggt ctccgacacc gcggcccgca gcacgtccat cagccacacc
    15301 ggcttgcgcc agcggcggcc cggctgcttg ccgccgagga tgatcaggtt ctcggtggtg
    15361 cggcgggcgc gggtggccag gtggtcgagc tggaacaggc ccttgagctg ctccgggttc
    15421 tcctcgcggc tttccatccg gtccaggatc tgcagctggc ggtgcaccag gccctggttg
    15481 cggtgggcga tgccgaggaa cacgttgttg acaccgctgc gcgccttggc ctcgctggcc
    15541 gcggcctgga cggcggtcag ctgggcgatg ttgaacgcct cggccacctg accgatctcg
    15601 tccttgccgt ggtccagccg gggcagctcg gcgctgacgt cgaccgactc gccctccttg
    15661 agccggttca cgatgctcgg caggcgggtg cgggccagct ccagcgagtc ggtgcgcagg
    15721 cgctccaggc gcgtcatcag ggtcctgtcg accagcgtgc gggacacccg gatggcgacc
    15781 cagatcgagg cgaccgccgc gagcagggcg gcgacgctgc cgatgatcac cgtccacagg
    15841 ttgacgttgc ccttgtccag cgcggcgccg gaggccagct ccgactgctc gacggtcagg
    15901 ttgatcagcc gccccgacac ctgcgtggtg aggtcgcgcc agtcgttctc ccgcacggtc
    15961 aggccgccga cgttctcgcg gaacgcgccc ggcccgtgcg tgatgatcga gttctccgcg
    16021 gcggcgaggc gctgccactc gtcgctggag gtcagttcgc ggtagcgctg cccggcctcg
    16081 ggggccatgt agccggcgat cttcgccagc tgggcgcggt agctgccgac gagctgggcg
    16141 aactgcaggt ggtcggccgg ggcgaactgg ccggaggcga acgcgctgga ggccagcgac
    16201 gcggcgcgcg acatctggtc cgaggcgcgg aagatgtcca ccgaggtcat gccgccctgg
    16261 gtcgactcgg cgtcgggcac caggcgggcc tgcgagtcga acaggtcggt cgaggtgtcc
    16321 agcaggcggt tgtagaagtc gttgacctgc tccttggaga tcgtgcgcag gttgatctcc
    16381 gcgcggatga ccgggagctg gtcgaggctg gactccatct ggttcatccg ctggccgatc
    16441 tcgtccggca cgaggctctt cacctcggcc agcgcggacc ggaggctggt cagcgacttg
    16501 tcgatggact gctgctgcgc ctgcaggtcg cgcaggccga cctgggggcg ttccaggtag
    16561 accagggaca gctggcgttc ctgctggacg gcgccgagcg cggtgacggc ggggatcgac
    16621 acgtcctgca cggaggaggc caccgtgcgc acgtagatcg cgtccaccag gaagtagccg
    16681 gagcccgcga tccacatcac gaggagcgcg atactcggga tcaggacggt tccggtcagg
    16741 cgctttcgaa tcgacttgtg gtggccttcg cctgacttgt catctgtgtt tttcacgacg
    16801 ctccacgaaa tcctggggac cgggacgaag acggcgacgt cacgacagag tcgtatgcaa
    16861 ccacccctgt caagccaggg ctgtcgacaa atgccctccc ggcggctcgg gggtcgttct
    16921 cactctgcgt cacagtcacc gatcactcga tagatgctct ggtcggactg aaatcatgtc
    16981 gtacggcgtc cgccaccgag ccgcgacccc ccggttactg tgcgcaaacc ccgttctccc
    17041 cggtaccggc ggcgcaccgg cccccgaaag cgctttcctc cgcgcggggg agatacgcag
    17101 cgcccatgtc gtcacccgtt cgcggagaac ggcgcccggt gtgcgtcagc cgtcgccgcc
    17161 ccacaaccgg cccaggggcc cggtcagctc acgctcctcg taggacaggt gcgacaggag
    17221 cgcgtcggtg agcacgtcga gcgccgcgtg cagtccggcg atgtccccgt cgctgccgac
    17281 gaacgcgacc agcgccgcgt cgacgcggtc gaccagggcc tggatggcgt ggtgctcgtc
    17341 ctcgaggcgg tcgagcacgg gcgcgagccc gggctcggac cgccgcaggg cggggaacac
    17401 gtcggagtcc tcgcggtggt ggtggacgct gaccacgcgg cagtaggact cgcagtaggc
    17461 gccgagcgtc cagttgttct ggcgcagggt gagggtgtgc aggtgggacc gcgcggcgcc
    17521 gggctcgagg gtgccggcgg cgactccggt gagcaggtcg cgcagccggg cgagctcggc
    17581 gcgcaggtgg tcgtgcacct cgacgagccg ccgaccggcg gtccgttccc gctcggtgtg
    17641 gcggcgccgg ggatccggct cgggagccga ggggcgggtg tcctcgtccc agacccgctc
    17701 ggtgctcacc cggatgctgt cgtccggggt ggcccggggg gccaggggcg tgcgggacgg
    17761 actgtgcccg ccccgcgccg tggcgacgag ttcccggacc gcgggggcga tctcggtggc
    17821 gaagagccgc accaggtccg ggccctcggc cgggagcagg aacgcgctca ccccgtgggt
    17881 gagcgccagc tcggcgagcc gcccgggcca gtcgcgcggg tggccgagcg ccggcgggga
    17941 caggttgtag agccggcgga tcgcggcggg gtcgcggtcc gcgtgcgcgg cggcggcgtc
    18001 gatgatcgcg ttggccgccg ggaggccggc gggcgggatg cgggtcatgc tcggcagcca
    18061 cccgtccgcc agcgtgccgg tcagccgcag catccgcggc ccgagcgcgc ccacccagat
    18121 ggccggctcg cgcggtgggg gaccgggttc ggcgccgtcg aggccgtagc gcttgccccg
    18181 caggtgggcc ggcccgccgg gtgtccacag cgcgcggatc accgcgatcg cctcgccgag
    18241 ggcggaaacc gcctccgcgg gcgcgtgcca cggcccgcct tcggccgtga tcgcgtccca
    18301 gtacgccccg gcgcccagcg ccaggccggc ccggccgccg ctgagcacgt ccaggctcgc
    18361 cacggcgcgg gccagcatcg cgggaggacg cagcggcagg ttggcgacgt tcgggaacac
    18421 ccgcacccgc tcggtccgcg ccgcgatcac cgacagcgtc gtccacgcct cggtgaactc
    18481 cggccggtac gggtggtccg gcacgctcac caggtccagc cccgcgcggt ccgcgacacg
    18541 cgcgagttcc agcgcttcgc cgggccgcgc cgtcgttggc acgaggaccg cgccgaagag
    18601 caggtcgtgg ccgtagtccg tcatcggctc gccaccgcgg gcaccagtcg tcccgggccg
    18661 gcgagcgcga ccagcgccgc cacgcccatc gcgatcgcgg acagcacgaa cgccgtggtg
    18721 tagccggatt cgaccgggaa ccgggtgccc gcgatgacct cgccggtcac gatcgtcgac
    18781 gcgatctgcg cgccgaacgt tccgccgatg gtgcgcatga tcgtgttgac cccggtcgcc
    18841 tcaccggtct gacgcgggtc gaccgcgccc acgacgaggt tggccagcga cgcgaaagcg
    18901 aacccgacgc cgatgccgag gatcccgttg cccaggtaga tgggccaccg cgtgccgtgc
    18961 gcgacggcga acaccacgaa cccggccgcg ccgaccacgc acgccagcac cagcggcagc
    19021 ttgaacccgg cctgcgcgcc gatgcgcccg gcgagcgggc tggcgaacag catggtcacg
    19081 gccatcggga tgatgaacag cccggcctcg gtgaccgacg cgccgaagcc gtacccggcc
    19141 cgcgacggcg tctcgaccag cagcggcacc agcgtgaacg cgccgtacat gccgaagccg
    19201 atgatcagcg cggtgatgtt ggaggtcagc accgcgggac ggccgagcag cccgatgtcg
    19261 atcagcggcc gcgccaggcg cctctccacc agcgcgaaca cgaccagcag gaccgcggcc
    19321 gccgcgaaca ggccgatgat cgccgccgag ccccagcccc acacccggcc ctcgctgatc
    19381 gccagcagca gcgcgaccag gccgccggtg agcagcaggg cgccggccca gtccacccgg
    19441 cccggcgaac gcaccggcga ctcgcgcacg aacgcggtca ccgcggcgat cccggcgacg
    19501 atcaccgcga acatcagcca gaagatccac tcccagctca gcgcgtcgac gatcagcccg
    19561 gggatgacca gcccggcgcc gaacccgatg ccgaaggtcg agctgatcca gccgatcgcg
    19621 accggcaccc gctcccgcgg gaactcgtcg cgcacgatgc cgaacgcgag cgggaacgtc
    19681 gcggcgccga cgccctggat cgcgcgggcg gcgatcagca cgccgatcga cggggccagc
    19741 gcggcgagca gcgtgcccgc cccggacacc gcgaggcacg ccaccagcac gcggcgcttg
    19801 ccgaacatgt cgccgaggcg gccgagcagc ccggtcgcga ccgacgccgt gagcaggaag
    19861 gcgctgagca cccaggacac ggtggttgtc gacctgccga actcggcctg cagggtcggc
    19921 aacgcgggca ccggcatggt ctgcagcaac gagaacgaca gcaccgcgat cagcagcgcg
    19981 gcgaagggtg cggaagttcg tgtcatgacg taatgattac acgacgacat gattacgtcc
    20041 agaagggtag gatcgccgcc atggaagacc gcgagacgcg accgccgacc ctgctcgccc
    20101 tgccctccta cctggccggc cacgtggcgc ggatcgggca tcgcgggctg gttgcggcgc
    20161 tgtccgagca cgacctgcgg ctgccgcact tcgccgtgct gaccgggttg tcggacttcg
    20221 ggccgctcgc gcagcacgcg ctggccgacc gcctcgggct caaccgcagc cacctcgtcg
    20281 ggtatctgga cctgctggag cgacgaggtt tcgtgcggcg cgaacgcgat cccgacgacc
    20341 ggcgccgcca gcgcgccgcc ctgaccgatt cggggatgcg gctggtgcgc cgcctgcagg
    20401 aggtggcgca ccgctcgcag gaggagtcgc tgggcgcgct gtccacttcg gaacgtcaaa
    20461 cgctggtgga cctgatgcga cgggtggtcg tggccgacga cgcggcgcgg aaggctgttg
    20521 tgcgggacta acggtcgggc agccagccga agctgtccac agtggatccg ctcggcgcgt
    20581 actccaagcc cacccagccc gcgtagccgg tcgcggccag gcgttccagc caggccgtca
    20641 cgccgagcgt cccggtgccc ggctcgtgcc ggccgggcgc gtcggccacc tgcacgtgcc
    20701 cggtgcgcgc cagcagcggc ggcgtgagca gcgcgtccag gtcgtcgccg ttggtgccga
    20761 ggtggtagat gtcggtcagc agtgcgatgt tgtccgcgcc gacctcgtcc gccagcgcca
    20821 gtgcgtccgc ggcgcgcagc agcgggtagt ccggcgcgcc ggacagcggt tccagcagca
    20881 ccgtgcccgg caaccgctcc gcggcgtagg cgaggttgtc caacagcacg tcccgcgaac
    20941 cgccggtccg gttgccgggc agcacgttga acaaccggca cccgagctgc tccgcgatcc
    21001 cggccgcgac gtccaccccg tcccggaact cgcccgtccg c
//
