LOCUS       NZ_BNAU01000004        22583 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000004
VERSION     NZ_BNAU01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 638827)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 560218
            Orig. end                         :: 582801
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22583
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22583
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22583
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12583](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12583)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    48..63
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.43"
                     /tool="antismash"
     misc_feature    732..746
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(913..929)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            933..2135
                     /locus_tag="IE290_RS20680"
                     /old_locus_tag="GCM10017786_41950"
     CDS             933..2135
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420287.1"
                     /locus_tag="IE290_RS20680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_41950"
                     /product="hypothetical protein"
                     /protein_id="WP_191246236.1"
                     /transl_table=11
                     /translation="MQASSQTVREPDQAAPGLLLDLEERIWRRRALLLPAAVYLGVRAL
                     GVVVLTVFAALHDTSLLSRIAAWDGQWYLKIAASGYELGPVPDALGHPNPHTPRAFFPA
                     YPFLIRLLAPAFGFTTAALVVSLAAGLVAAYGLARLGRLVRGGSRRAGYVLVALFAATP
                     MSVVLTMAYTEALFCALAVWTLVAVLERRWEFAGVCCLVAGLVRSTALALVVAVVVAAL
                     FALARREGGGRPLAALAVAPVGLFGYLWWTGMRVRPESGFEAQLSTWSDLEWQGWRTRF
                     DGGVSTIRFVAEVLTGSDSAMSVLTVAVILGALAGLALLARRETVLAVYAAGVMVMCLG
                     SSSLMHAKPRLLLPAFTLLVPVAIALAKRRTNTVWWVCSGVALASAWFGAFALTVWQYA
                     I"
     gene            2164..2490
                     /locus_tag="IE290_RS20685"
                     /old_locus_tag="GCM10017786_41960"
     CDS             2164..2490
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS20685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017786_41960"
                     /product="hypothetical protein"
                     /protein_id="WP_191246237.1"
                     /transl_table=11
                     /translation="MTEPGDADSYVSIVEPEMDNGRAVLRFVTTSARDAAAIVAYWCKI
                     GYVYTADFADESVIINFGRVTRAHTHQGSRFRGVGLPTAAWSVKPSAADIARARAALAR
                     QGEL"
     gene            2520..3110
                     /locus_tag="IE290_RS20690"
                     /old_locus_tag="GCM10017786_41970"
     CDS             2520..3110
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420285.1"
                     /locus_tag="IE290_RS20690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_41970"
                     /product="nitroreductase family protein"
                     /protein_id="WP_191246238.1"
                     /sec_met_domain="PF00881 (E-value: 6.8e-12, bitscore: 41.0,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKPAESSVPLTDVIAQRWSPRALDETREVSWDQLRALLEAARWA
                     PSFGNTQPARFLAGRRGDATFRQILGTLTERNQAWAHRAGALLIGIMVSRNEKGEIPYA
                     EYGLGMAAQNLVLQAVAEGLVAHQMAGFDAEAVRERFAVPDDAIPRVAIAVGHAGDPAV
                     LEVDKLIERERAPRKRLPLGEFAYTGEWGTPAF"
     gene            complement(3107..6196)
                     /locus_tag="IE290_RS38285"
                     /old_locus_tag="GCM10017786_41980"
     CDS             complement(3107..6196)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037660.5"
                     /locus_tag="IE290_RS38285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_41980"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_191246239.1"
                     /transl_table=11
                     /translation="MTTGGRPGGVRSLLDEASARRLVVVIGAAGWGKTSAVAAWAESRP
                     AVWARAGEHDRLLRPIARDPEQLRRSGAGELFLIIDDVQALSAENGSAAVVETICQNAP
                     EWLHVMLLSRAELPFSLARLRGRGMVAEIDATHLAVRPAWIEALVQATVGDDPPGLAAM
                     IHQCTAGWPVAVRTVVEMMRDVAPGQRAAVLRRLTAPGERFHGFLTEEVLGQEPPAARA
                     ALRRLAVLGEISAPGPEQERLLTELTRRGLVTRTAGDVLRWSLIRPLAHYFSHEAVLST
                     RERVELHLEAGRRYLSQGAPADALRHLASAGAHSACAALLVEHGDALVMSGHGDAVLEA
                     AGLPTEFLDDPRIHQVLGEAQRTAGHWAAAMESFRRASRFHEEPDAALGWRIGMLAFTQ
                     GEFGNTLDVLGRTRLGEEDTEDEARALALLATTCRMVGETGRARQAMARAEAAATRSGT
                     PGARAAIHQVLAMLAAAEPDRREADVQCLNALHSAQALGDLLQVGWIRVCHAFHACDMG
                     SPRQALAEAKLALRTSEQCGCPFLTGHAHTVRARAHLMLGALDEAAADLHTAVDTFQRL
                     GSRFLAWPLCVLGDLHRTRGQLVRATADYEEALAVAQPHHDLFALGHALIGLARVRAAD
                     DLATARTLADRALAFGEGLLEIPGRLTSGWVALLAQDRDRAAADAARAAKAARLRRDGP
                     GLAEAITLGVLSSPDPAARADLLDEAVDLWHEHGCRLEEAVTRVVAARIGAPVPEADVC
                     LAEETLRQAGVDIGGRRAAGPLAASRPSGPAVFIRALGAFQVVVDGTPVPKTAWQSRKA
                     RDLLKILVTRRRPVPREQLMELLWPSADPVKAGNRLSVLLSLVRDVLRQGQSAGGPLAS
                     DGNAVWLDRSRVRVDLEEFLAAAEAALRAHRTGQADATARLTAAAAACTGEVLEDEPYQ
                     EWAPLLAEEVRATHFAVLRALASRLRQAGDVDGAVRYTLRLLAKDVYDEEAYLMLIATL
                     RDAGRLGEARRYDRIYRTRMKEMGIAPHSSPLAQLRSHPA"
     misc_feature    complement(6259..6273)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.1"
                     /tool="antismash"
     gene            complement(6397..8103)
                     /locus_tag="IE290_RS20700"
                     /old_locus_tag="GCM10017786_41990"
     CDS             complement(6397..8103)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075999.1"
                     /locus_tag="IE290_RS20700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_41990"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_191246240.1"
                     /transl_table=11
                     /translation="MKREIRFGLRALHRRPLLALLAWSVPEALPTTISGLAIAKAMDDG
                     FLAARPVTGLAWLGAFLLAACVGAWGSRQVFRRLGDLVEPFRDDLLRRVVGGALAHAVA
                     GHRDDGAMARVTRQVEIVRDSFAGLIVVTRGFAVTVAGVVLGLLSIDPVIVGLILPPFA
                     LGFGAFVATLGLAAARERATVLAEERVGDTANAVLSATRDVVATGAEGHAAALAAEPIE
                     EQAAAERALAWVAVLRTFCFAAGVWLPLIVLLFAAPWLVGRGLTTGAIMGGLTYILMGL
                     NPALQTLVTGVGSSGLQFVVTLGRILDATAPPERPGPLVSTTPCGHDIALDGVTFAYGP
                     HAEPVLDDLDLVVPEGDHLAIVGPSGIGKSTLAGLVCGLLRPGSGSIRLGGASVTGLTP
                     AQLARLRVLIPQEAYVFSGSVWDNLVYLRPSAEVSQVDRAVAEVGAEHLLARLGGYPAA
                     VVPAELSAGERQLIALVRAYLSDAPVVILDEATCHLDPIAERRAEEAFAARGGTVVVIA
                     HRISSALRAKRVLVLDGTDAVDGDPVALRSVSPLYRELLGYWHAEPPVPVN"
     gene            complement(8100..9749)
                     /locus_tag="IE290_RS20705"
                     /old_locus_tag="GCM10017786_42000"
     CDS             complement(8100..9749)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076000.1"
                     /locus_tag="IE290_RS20705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42000"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_191246241.1"
                     /transl_table=11
                     /translation="MSTTFGAIVRRGGAWLPVIGFAALAGTLSTLALPAVLGRAVDAIV
                     AGDDSGRWLLLAAALVVVGILADLIDASAGIACVAGTTAWLRNRLVRQVLRMGPDRARR
                     FDTGDLVSRISGNAVDAAQAGPSVVTVVAAVLPPAGSLVLLVVIDPWLAVAFVAGLAVV
                     AAVLRAFTVRSTAVFTAYQRTQGRIAARLAESLAGARTIAAAGTAGREESRVLEPLPEL
                     HGHGRQTWQVLSRAAAQGAVAGPLVLVAVLAVGGLALVDGRITAGDLFAASRYAVLGAG
                     LGGLAGVFGQLARARAGAARAAEVLTVPAVEYGSRALPEGTGRLEFRHVTVRSDGTTLL
                     DDVDLTVPGGATVAVVGHSGAGKSVLAALAARLRDPDEGEVLLDGVPLGELSHEALRAA
                     VCAAFERPVLVGATVADAIGSGRDRASVLTAARATHAHDFVSRYPEGYDTPLADAPMSG
                     GEAQRLGLARAWHARRLLVLDDATSSLDMVTEMQISRTLTDDGGRTRLIVTHRVSTAAR
                     ADCVVWLDAGRVRAVAPHHRLWQDAGYREAFG"
     gene            complement(9819..9968)
                     /locus_tag="IE290_RS20710"
                     /old_locus_tag="GCM10017786_42010"
     CDS             complement(9819..9968)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="IE290_RS20710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42010"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_191246242.1"
                     /transl_table=11
                     /translation="MALLDLQGMESAAPEWGGGGSSASGKSCPSNLSVTLCGGTSGLSV
                     LICH"
     CDS_motif       complement(9906..9968)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGMESAAPEWGGGGS"
                     /locus_tag="IE290_RS20710_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9819..9905)
                     /prepeptide="core"
                     /locus_tag="IE290_RS20710_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="6.50"
                     /molecular_weight="2516.9"
                     /monoisotopic_mass="2515.3"
                     /core_sequence="SASGKSCPSNLSVTLCGGTSGLSVLICH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGMESAAPEWGGGGS"
                     /leader_location="[9905:9968](-)"
                     /alternative_weights="2534.9"
                     /alternative_weights="2552.9"
                     /alternative_weights="2570.9"
                     /alternative_weights="2589.0"
                     /alternative_weights="2607.0"
                     /alternative_weights="2625.0"
     gene            complement(10001..12583)
                     /gene="lanKC"
                     /locus_tag="IE290_RS20715"
                     /old_locus_tag="GCM10017786_42020"
     CDS             complement(10001..12583)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="IE290_RS20715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42020"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_191246243.1"
                     /sec_met_domain="micKC (E-value: 3.4e-248, bitscore: 821.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.3e-13, bitscore: 46.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.2e-05, bitscore:
                     17.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEYERFCMADSSFYDAMHSERTAGPSFATARLPLPDGWRRYEQD
                     DWFVLDPGATGLPAQGWKIHVSATPGNAEKILDAVWDYCVPRRIEFKFLRSPAALTARV
                     SKYAPRGYSGKLVTIYPPDLGACETILRELGETLDGEPNPYILSDLRWGRGPLFVRYGA
                     FVNRYMVTENGDVVPAIADGEGRLVPDRRGPVFHVPPWVTLPDFLAPHLEARNAVTVAG
                     LPYTIERVVHFSNGGGIYVGRDNRTGAQVVLKEGRPHAGLDAWGHDAVRRVEHEHDILR
                     RLAGIPGIPEVHDLFWLGEHRFLVMEYVEGDVLGKAIVRRYPLIDPSAGPEDYRDFTDW
                     AMGIQRQIEETMRAVHERGIVYGDLHLFNVMVRADGTIRLLDFEVAAPVAEAARPGLGN
                     QGFAAPRSVTGFDIDRYALACLRLALFLPMTYLFGLHRVKARQFAEIIAEHFPVPRSYL
                     TEAVDVIVPPGTPHLPHPRIEPDPADWPELRDDLVRAIVASATPERDDRLFPGDPEQFA
                     TGGIGLAHGAAGVLYALSATGADPSPVFEKWLVDRATNPPGGTRLGLFDGLHGAAFALD
                     HLGYRQQALDVLDICLRENWEALGPDLGGGLAGAGLNLLHFAGRTGDPTLRRAAHRAVE
                     LVAERVGDAADGPEISGRDGSFAGLMRGGAGKALLLLRAYDDTGDTALLDRAAIALRQD
                     LRQCVVRDSGALEVNEGWRTMPYLDVGSVGIGLVLDEFLARRDDAEFAEANRRIQLAAQ
                     SPMYILPGLFSGRAGILLYLAGRSPDPPRDPSVARQVRALAWHALPFGGGTAFPGTGLL
                     RLSMDLATGTAGVLLALGSVLADPPVHLPLLAPAPAPQTSAPAVGAAG"
     gene            complement(12692..13075)
                     /locus_tag="IE290_RS20720"
                     /old_locus_tag="GCM10017786_42030"
     CDS             complement(12692..13075)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985536.1"
                     /locus_tag="IE290_RS20720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42030"
                     /product="hypothetical protein"
                     /protein_id="WP_191246244.1"
                     /transl_table=11
                     /translation="MAEHAEKRKSDVDEDEPPRPKRQVPWGRVKDQAIGLIAGIVRWVG
                     LIFALILVLHVIFVVGGANPDNGIVSFVRDWSDGLALGFKDLFEPADEKLRVLVNYGIA
                     AIFWLVVSSIVTRIIRRIGGSSV"
     misc_feature    13145..13158
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.75"
                     /tool="antismash"
     gene            13301..15076
                     /gene="leuA"
                     /locus_tag="IE290_RS20725"
                     /old_locus_tag="GCM10017786_42040"
     CDS             13301..15076
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787904.1"
                     /locus_tag="IE290_RS20725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42040"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_191246245.1"
                     /sec_met_domain="HMGL-like (E-value: 7.5e-77, bitscore:
                     253.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSDPTASRIRKPSRPAPADQPAWNPQRGSSMPVHRYQPWYKLV
                     ENIELPDRTWPDKRIERAPLWCAVDLRDGNQALIDPMSPARKRKFFELLVRMGYKEIEV
                     GFPAASQTDFDFVREIIEDGAIPDDVRIQVLTQCRPELIERTFQSLEGAPQAIVHIYNS
                     TSILQRRVVFREEREGIKKIALQAADLVVEYAQKYSDTDFRFQYSPESYTGTELSYAAE
                     VCNAVTDIWQPTPDRPVILNLPATVEMATPNVYADSIEWMGRNLDRRDAVILSLHPHND
                     RGTGIAAAELGYQAGADRIEGCLFGNGERTGNVDLVALGMNMFSQGIDPQIDFSDIDEI
                     KRTVEYCNQLPVHERTPWGGDLVFTAFSGSHQDAINKGFDALHRAAEKAGVPVDEFPWE
                     VPYLPIDPKDVGRSYEAVIRVNSQSGKGGVAYIMKTEHQLDLPRRLQIEFSQVIQRYTD
                     SEGGEVDPRTMWDAFAKEYLEPQTPLQLISQHVTANGDYQLRATVRVDGEEQEITGSGN
                     GPIAAFFDALSTVGYDLRLLDYSEHTLTPGDDARAASYIECAIGDKVFWGIGIDPSIVT
                     ASLRAVVSAVNRAHR"
     gene            complement(15124..15609)
                     /locus_tag="IE290_RS20730"
                     /old_locus_tag="GCM10017786_42050"
     CDS             complement(15124..15609)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985538.1"
                     /locus_tag="IE290_RS20730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42050"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_191246367.1"
                     /transl_table=11
                     /translation="METRFNLMANEVGAKLAKRFAGVAAVLQSTALPQSTQELVSLRAS
                     QINGCALCVDMHTKEAAAAGETATRLNLVAVWREATVFTEAERAALALAEEGTRLADAH
                     EGVSDETWAQVRKHYDDDQTAALITLVAMINAANRMNVIVRNQGGSYQPGMFSAAAH"
     gene            complement(15686..16597)
                     /locus_tag="IE290_RS20735"
                     /old_locus_tag="GCM10017786_42060"
     CDS             complement(15686..16597)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420275.1"
                     /locus_tag="IE290_RS20735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42060"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_191246246.1"
                     /transl_table=11
                     /translation="MDIGRLRVLREFADRGSVTAAAKALHCTPSAVSQQLRALQAEVGL
                     VLTEPAGRGLRLTDAGRALVVRADEVIAAMDRAEAEMDVFRSLPRGRVRVAIFPSAALM
                     LLPGLLHRFAEVEGLDVEVRDVDMTPAEVPELVADFDIVVTHRDEHAEPFPSARLDVVH
                     LLREPLDVALPLGHHLARRRRVDLTELAGEQWISVDVGFPVDDVLRSLAVRTGVRPRVK
                     QRINDFRIIEALVAAGHGIALLPRYTLAGTWSRRIVRRPLAGIRAARLIEAVLRTGAGT
                     RPPVATVLELLHAEAAAVTTKP"
     gene            16669..17577
                     /locus_tag="IE290_RS20740"
                     /old_locus_tag="GCM10017786_42070"
     CDS             16669..17577
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420274.1"
                     /locus_tag="IE290_RS20740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42070"
                     /product="EamA family transporter"
                     /protein_id="WP_191246247.1"
                     /transl_table=11
                     /translation="MPTRDRLLALFVVVLWGLNFIAMHPMLDHFPPLFAGALRFAVIAV
                     PTILFIPRPKVKLRWLIGFGLGFGTGQFAFLFLALTNGMPTGLASLVLQASAPFTVLLG
                     GIFLREPLSARQLTGILAAVAGMGVIAWHRAENAVLLPVVLTLLGALCWAIGNICSRQA
                     KPENPIHLTLWMSVIPPIPMFALSTVFEGPAVQWHSLATLGTGEGLLGLAGFTYVVLVG
                     TVLGSSIWTVLMRRNPANVVAPFSLLVPVVGMSAAFFVLGETPALVEVLAGLVVVAGVL
                     FGSLPRRQRSAGALSAELVSS"
     gene            complement(17532..18176)
                     /locus_tag="IE290_RS20745"
                     /old_locus_tag="GCM10017786_42080"
     CDS             complement(17532..18176)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985541.1"
                     /locus_tag="IE290_RS20745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42080"
                     /product="DedA family protein"
                     /protein_id="WP_191246248.1"
                     /transl_table=11
                     /translation="MHIDAWLETIPPLAVYLAVGLVIGCESLGIPLPGEVVLVSAALLA
                     SHHDGLNPWLIGAVGSGGAIAGDSIGYLIGRKGGQRLFDWAGRRFPKHFGPSHVAAAER
                     MFRKRGMWAVFFGRFVAILRILCGPLAGSLHMHYPRFLLANALGGIVWAGGTTALVYSL
                     GVVAEKWLSRFSYLALAVAVVVGVVVSLVIKKRMARRHEETSSAESAPADR"
     gene            complement(18226..19326)
                     /locus_tag="IE290_RS20750"
                     /old_locus_tag="GCM10017786_42090"
     CDS             complement(18226..19326)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985542.1"
                     /locus_tag="IE290_RS20750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42090"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_191246249.1"
                     /transl_table=11
                     /translation="MSEPLVRVEGMQVHFPIKRGLVLDRTIGHVYAVDGVDLEIQRGET
                     YGLVGESGCGKTTLGRSLLRLVEPTGGRAVFDGVDLSTLKGESLRKMRRRMQMVFQDPL
                     SSLDPRQSVESILIEGMRAHGLDRDRDSTRKRLRELLNAVGLPESSLRKYPHEFSGGQR
                     QRIGIARALAVEPDLIVADEPVSALDVSVQAQVINLLEELQDSLGLTYLVIAHDLAVVR
                     HISDRIGVMYLGSLVEETDSETLYDEPLHPYTRALLSAIPVPDPVVEDGREQILLAGDL
                     PSPANPPSGCRFHTRCPWRQETKCDTERPALRELGAGHRVACHWAEDIQAGRITPHEVK
                     PELVTAQLSPDTAIPQAASVAEMLEP"
     gene            complement(19326..20321)
                     /locus_tag="IE290_RS20755"
                     /old_locus_tag="GCM10017786_42100"
     CDS             complement(19326..20321)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230614.1"
                     /locus_tag="IE290_RS20755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42100"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_191246250.1"
                     /transl_table=11
                     /translation="MSLLQVRDLSVVFSRKGTRPFTAVDGVSFDVEPGRTVGLVGESGS
                     GKSVTALAIMGLLPKRGARVTGEVMFEDTDLLQLSDRQLRDRRGRDLGMVFQDPLSSLN
                     PVIPIGLQITEVLERHRKMERKQARVEAADLLDRVGIPDPNRRLSEYPHQLSGGMRQRA
                     LIAIALACRPRLLIADEPTTALDVTIQAQILALLSELVRETGTALIMITHDLGVVAGLC
                     DEVNVMYGGRVVERAERHALFASARHPYTHGLLASIPRLDAPRGEKLVPIKGSVSDNIP
                     WSQGCAFAPRCPNALELCREVTPELEPDTGGMLRCHNPVDRPVAAGEGVR"
     gene            complement(20326..21252)
                     /locus_tag="IE290_RS20760"
                     /old_locus_tag="GCM10017786_42110"
     CDS             complement(20326..21252)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337932.1"
                     /locus_tag="IE290_RS20760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42110"
                     /product="ABC transporter permease"
                     /protein_id="WP_191246251.1"
                     /transl_table=11
                     /translation="MTSMLRRKAERIDDLAEAGGTSLAADAVRRMARSPVAITGAVITV
                     LFVLLAILAPFLAPKNPYVPYDELRVNLRPDFIPGPMDGFVMGSDHRGYDFFSRLLVGA
                     QQTLIVGVVATLIGLTVGMLIGGLAGALGGWVDTLLMRFTDILLAIPSLLLAISIAALF
                     SQGTQWTVIIAVAVVSVPIFARLLRGAMLSQRSSDHVLAATALGVRRSTIVFRHMLPNS
                     LGPVVVQATLTLATSIIDVAALSFLGLGDNDPSRAEWGLMLAQAQNLLDVKPSLAFYPA
                     IAIVVVALGFTLLGESLREALDPKNRR"
     gene            complement(21249..22253)
                     /locus_tag="IE290_RS20765"
                     /old_locus_tag="GCM10017786_42120"
     CDS             complement(21249..22253)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005166271.1"
                     /locus_tag="IE290_RS20765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_42120"
                     /product="ABC transporter permease"
                     /protein_id="WP_191246252.1"
                     /transl_table=11
                     /translation="MLRFVIRRLLQAIPTLLVLSILVFAWLRLLPGGPATALLGDKATP
                     EKVASLNSVLGLDQPIFVQYFKFLGRVLTGDFGSSLISGDTVLTEIGRAFPATVELSLA
                     ALVLAVGFGIPMGYLAARYRGRLLDNATVLTTLVGVAVPVFFFGVLLKYVFAQKLGVLP
                     PSGRQDVTIDATHITGFFTLDGLLTGELDATWDAIKHLILPAIALASIPFAVIVRITRA
                     SVLDVQQEDFVRTAESKGLTTGTIRQRHVLRNALLPVSTTIGLQTGLLLAGAVLTEKVF
                     NWNGVGALLAQGIERRDYPRLQALLLLAAVVYVLVNLLVDISYAIIDPRVRVR"
     misc_feature    complement(22486..22495)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 ggtgacggtg accttggcct ccgaccggtc gtgcgccaca ccggtgatca acgcttgttc
       61 cacggggatc tcctcaatcg aaccggccac ggtggtgccc ggcttgtcgc tgtaggacga
      121 acggacccgg atcggcacgc cgtagcggcg ggcgtactcg accgagcgca ggtgcaggat
      181 cttcgaaccg ctcgcggcga gttcgagcat ctcctcgtac gggatggtgt cgagcttgcg
      241 tgcgttgggc acgatccgcg ggtcggcggt gtacacgccg tccacatcgg agtagatctc
      301 gcacgcgtcc gcgttgagcg ccgcggccag cgccaccgcg gtggtgtccg aaccgccgcg
      361 gccgagcgtg gtgatgtcct tggtgtcctg cgcgacgccc tggaacccgg cgaccagcgc
      421 gatgtaaccc tggtcgagcg cctcggtgac ccggctgggc gtcacgtcga tgatgcgcgc
      481 gttgccgtgc acgcccgtcg tgaccacgcc cgcctgggac ccggtgaacg accacgcttc
      541 gaaaccgtgt gccgaaatcg ccatcgcgac aagcgcgttg gaaatgcgct ccccagcggt
      601 gagcagcatg tccatctctc gttcgggcgg caccgggttg acctgctggg ccaggtcgag
      661 caactcgtcg gtggtgtcac ccatggcgga gcagacgacg accacgtcgt tgcccgcctt
      721 cttggtggcc acgatccgtt cggccacgcg cttgatgcga tcagcgctct ccagcgacga
      781 accgccgtat ttctggacca cgagcgccac ttgtctgccg acctcctatt tcgcaccttt
      841 cggagcagcc taccggggct tacggccctg gccaccccgt tatgtggctc cggccactgc
      901 ctcggcggga gttcgtggga aaatgaccaa ccgtgcaggc gagcagccaa accgttcgag
      961 aaccggacca agcggcccct ggcctgctgc tggacctgga agaacggatc tggagacgcc
     1021 gggcgctcct gctgcccgcc gccgtctacc tcggtgtccg ggctctcggt gttgtggtgc
     1081 tcacggtctt cgccgcgctg cacgacacga gcctgctgtc taggatcgcc gcctgggacg
     1141 ggcagtggta cctgaagatc gccgcgtccg gctacgaact cgggccggtt ccggacgcgc
     1201 tcggccaccc gaatccgcac acgccgcggg ccttcttccc ggcgtacccg ttcctgatcc
     1261 ggctgctggc gcccgcgttc gggttcacca cggcggcgct ggtcgtgtcg ctggccgcgg
     1321 ggctcgtcgc cgcctacggc ctggcgcggc tcggccgtct cgtgcgcggc ggttcgcggc
     1381 gggccgggta cgtcctggtc gccctgttcg cggcgacgcc gatgagcgtc gtgctgacca
     1441 tggcctacac ggaggcgctg ttctgcgcgc tggccgtgtg gacgctggtt gcggtgctgg
     1501 agcggcggtg ggagttcgcc ggggtgtgct gcctggtggc cgggctggtg cggtcgacgg
     1561 cgctggcgct ggtcgtcgcg gtggtcgtgg cggcgttgtt cgcgttggcg cgccgggagg
     1621 gcggcggccg tccgctcgcc gcgctggcgg tggcgccggt ggggttgttc ggttacctgt
     1681 ggtggaccgg tatgcgggtg cggccggagt ccgggttcga ggcgcagctg agcacgtggt
     1741 ccgacctgga gtggcagggg tggcggaccc ggttcgacgg cggggtgtcg accatccggt
     1801 tcgtggccga ggtgctgacg ggcagcgact cggcgatgag cgtgctgacg gtggcggtga
     1861 tcctgggcgc gctggccggc ttggcgttgc tcgcgcggcg cgagacggtg ctggcggtgt
     1921 acgcggccgg ggtgatggtg atgtgcctcg ggtcgagcag cctgatgcac gccaagccgc
     1981 ggttgttgtt gccggcgttc acgctgctgg tcccggtggc gatcgcgctg gccaaacgcc
     2041 ggacgaacac ggtgtggtgg gtgtgctcgg gcgtcgcgct cgccagcgcc tggttcggcg
     2101 cgttcgcgct gacggtttgg cagtatgcga tttgatgcgc gacgacgcat cgaggagggg
     2161 accatgacgg agccgggcga cgctgacagt tacgtcagca tcgtcgaacc ggagatggac
     2221 aacggccggg ccgtgctccg gttcgtcacg acgtccgcgc gggacgcggc cgcgatagtg
     2281 gcgtactggt gcaagatcgg ttacgtctac acggccgatt tcgccgacga gtccgtgatc
     2341 atcaatttcg gacgggtcac gcgtgcccac acccaccagg gcagccggtt ccggggcgtt
     2401 ggactaccca cggccgcgtg gtcggtcaaa ccctccgccg ccgacatcgc gagggctcgc
     2461 gcggcgctgg cccgccaggg tgaactctga ctccggccgc actggcagta tgcgatttga
     2521 tgcgcaagcc agccgaatcc agcgtgcccc tgaccgacgt gatcgcgcag cggtggagtc
     2581 cgcgggcgct cgacgagacg cgcgaggtca gctgggacca gctgcgcgcg ttgctcgaag
     2641 ccgcgcggtg ggcgccgtct ttcgggaaca cccagccggc tcgcttcctg gccggccggc
     2701 ggggtgacgc gaccttccgg cagatcctcg gcacgctcac cgagcggaac caggcctggg
     2761 cgcaccgcgc gggcgccctg ctgatcggga tcatggtgtc gcgcaacgaa aagggcgaaa
     2821 tcccctatgc cgagtacggg ctcgggatgg ccgcgcagaa cctggtgctg caggccgtcg
     2881 cggaggggct cgtcgcgcac cagatggccg ggttcgacgc cgaggccgtc cgcgagcgat
     2941 tcgcggtgcc cgacgacgcg atcccccgcg tcgcgatcgc cgtcgggcac gccggggatc
     3001 cggcggtgct cgaggtggac aagctgatcg agcgcgaacg ggcgccccgg aaacgcctgc
     3061 cgctgggcga attcgcctac accggcgagt ggggcacgcc cgcgttctag gccgggtgcg
     3121 accggagctg agccagcggc gacgagtgcg gcgcgatgcc catctccttc atccgcgtgc
     3181 ggtagatccg gtcgtaccgg cgggcctcgc cgagacgtcc ggcgtcgcgc agcgtggcga
     3241 tcagcatcag gtacgcctcc tcgtcgtaga cgtccttcgc cagcagccgc agcgtgtagc
     3301 gcaccgctcc atcgacgtcc cccgcctgcc gcaaccggga ggcgagcgcg cgaagcaccg
     3361 cgaagtgcgt cgcgcggacc tcctccgcca gcagcggagc ccactcctgg tacggctcgt
     3421 cctccaggac ctccccggtg cacgcggccg cggccgcggt cagccgggcc gtcgcgtcgg
     3481 cctgcccggt gcggtgcgcc cgcagcgccg cctcggcggc ggcgaggaac tcctccaggt
     3541 cgacccgcac ccgcgaccgg tcgagccaca ccgcgttgcc gtcgctcgcc agcgggccgc
     3601 cggccgactg gccctgccgc agcacgtccc ggaccaggga cagcaggacc gacaaccggt
     3661 tgccggcctt gaccgggtcg gctgacggcc acagcagctc catcagctgt tcgcgcggta
     3721 ccggacggcg acgggtgacg aggatcttca gcagatcccg agccttgcgc gactgccagg
     3781 ccgtcttcgg caccggcgtg ccgtccacca ccacctggaa ggcgccgagc gcacggatga
     3841 acaccgcggg gccggacggg cgtgaagccg ccagcggtcc cgccgcccgg cggcccccga
     3901 tgtcgacgcc cgcctgccgc agggtctcct cggccaggca cacgtcggcc tccggcaccg
     3961 gggccccgat gcgtgccgcc accacccgcg tcaccgcctc ctccaggcgg cacccgtgct
     4021 cgtgccagag gtccaccgcc tcgtcgagca ggtccgccct ggcggccggg tccggcgacg
     4081 acaacacgcc gagcgtgatc gcctcggcga ggccggggcc gtcccgccgg agccgcgcgg
     4141 ccttcgccgc ccgcgccgcg tcggcggcgg cccggtcccg gtcctgggcc agcagcgcga
     4201 cccagccgct ggtgaggcgc cccgggatct ccaacagccc ctcgccaaac gcgagcgcgc
     4261 ggtccgccag cgtgcgggcc gtggcgaggt cgtcggcggc ccggacgcgg gccagcccga
     4321 tcagcgcgtg cccgagggcg aacaggtcgt ggtgcggttg cgccaccgcg agcgcttcct
     4381 cgtagtccgc ggttgcgcgg accagctgtc cgcgcgtgcg gtgcaggtcg ccgagcacgc
     4441 acagcggcca ggccaggaac cgggatccga ggcgctggaa ggtgtccacg gccgtgtgga
     4501 ggtcggccgc cgcctcgtcc agtgcgccga gcatgaggtg cgcccgcgcg cggacggtgt
     4561 gggcgtgccc ggtgaggaac gggcacccgc actgctcgct cgtgcggagc gcgagcttgg
     4621 cctcggcgag cgcctgccgc ggtgacccca tgtcgcacgc gtggaaggcg tggcagaccc
     4681 ggatccagcc gacctgcagg aggtcgccga gcgcctgcgc gctgtgcaac gcgttgaggc
     4741 actgcacgtc ggcttcgcgc cggtccggct cggcggccgc gagcatcgcc agcacctggt
     4801 ggatcgccgc ccgcgcgccc ggggtgcccg accgtgtggc ggcggcttcc gcgcgcgcca
     4861 tcgcctgccg cgcccggccg gtctcgccga ccatccggca cgtcgtcgcc agcagcgcca
     4921 gtgccctggc ctcgtcctcg gtgtcctcct cgcccagccg ggtgcggccc agcacgtcca
     4981 gcgtgttgcc gaactcgccc tgggtgaagg cgagcatgcc gatgcgccag ccgagcgcgg
     5041 cgtcgggctc ctcgtggaac cggctcgcgc ggcggaagct ctccatggcc gccgcccagt
     5101 ggcccgccgt ccgttgcgcc tcaccgagga cctggtggat gcggggatcg tcgaggaact
     5161 cggtgggcag cccggcggcc tccagaaccg cgtcgccgtg gccgctcatc accagggcgt
     5221 cgccgtgctc gaccagcaac gcggcgcagg cggagtgcgc gcccgccgac gcgaggtgcc
     5281 gcagcgcgtc ggccggcgcc ccctggctga ggtagcgccg cccggcttcg aggtgcagct
     5341 cgacccgttc gcgggtggac agcacggcct cgtgggagaa gtagtgcgcc aggggacgga
     5401 tcagcgacca gcggagcaca tcgcccgcgg tgcgcgtgac caggccccgg cgggtcagtt
     5461 cggtcagcag ccgttcctgc tccggccccg gagcgctgat ctccccgagc acggcgagcc
     5521 ggcgcagtgc cgcgcgggcg gccggcggct cctggccgag cacctcctcg gtgaggaacc
     5581 cgtggaaccg ctcgccgggc gcggtcagcc gccgcagcac cgcggcgcgc tgcccgggcg
     5641 cgacgtcccg catcatctcc acgaccgtcc gcaccgcgac cggccagccc gcggtgcact
     5701 ggtggatcat ggcggccagc ccgggcggat cgtcgcccac ggtggcctgg accagcgcct
     5761 cgatccaggc cgggcggacg gccaggtgcg tcgcgtcgat ctccgccacc atcccgcggc
     5821 cgcggagccg ggcgagcgag aacggcagtt ccgcgcggga caacagcatc acgtgcaacc
     5881 attccggcgc gttctggcaa atcgtttcga caaccgcggc ggaaccgttt tccgcactca
     5941 atgcctgaac gtcgtcgatg atcaggaaca gctccccggc gcccgatcgg cgcagctgtt
     6001 ccgggtcccg ggcgatcggg cgcagcagcc ggtcgtgctc cccggcgcgg gcccacaccg
     6061 cgggccgcga ctccgcccac gccgccaccg cactggtttt tccccagccg gcggcgccga
     6121 tcacgaccac caatcgccgc gcggacgcct cgtcgagcag actgcgcacc ccgcccggtc
     6181 gcccccctgt cgtcacggct ggtcctccct ctgcccggcc acgaaccacc gccgaattcg
     6241 ccgcgatcac atccgtggaa ttcaccggat aatccgagat cgaaaacgaa tggccccgga
     6301 cgattctatt ctgcggcgag ggccggaatc aaatcgacga gcgattttcc cgcctgccgc
     6361 gcgggtggaa atacactcgc agggcgcgcc cggttttcaa ttcaccggga ccggcggctc
     6421 ggcgtgccag tacccgagca gctcccggta cagcggcgag accgaccgca gcgccaccgg
     6481 atcgccgtcc accgcgtcgg tcccgtcgag caccagaacc cgcttggcgc gcaaggcgga
     6541 actgatccgg tgcgcgatga ccaccaccgt gccgccgcgg gccgcgaacg cctcctcggc
     6601 gcgccgctcg gcgatcgggt ccaggtggca ggtcgcctcg tccaggatca cgaccggcgc
     6661 gtcggacagg tacgcgcgca cgagggcgat caactgccgt tccccggccg acaactcggc
     6721 cggtaccact gcggccgggt atccgccgag gcgggcgagc aggtgttccg cgccgacttc
     6781 ggccaccgca cggtccacct gggacacctc ggccgacggc cgcaggtaga ccaggttgtc
     6841 ccacaccgag ccgctgaaca cgtacgcctc ctgcgggatc agcacccgca gccgggccag
     6901 ctgggccggg gtcaggccgg tgacggacgc gccgccgagc cggatcgaac cggacccggg
     6961 ccgcagcagt ccgcacacca ggccggccag ggtggacttg ccgattccgc tcggcccgac
     7021 gatcgccagg tgatcccctt ccggcaccac gaggtcgaga tcgtcgagca ccggctcggc
     7081 gtgcggcccg taggcgaacg tgacgccgtc gagggcgatg tcgtgcccgc acggcgtggt
     7141 ggagacgagc gggccgggcc gttccggtgg ggcggtggcg tcgaggatgc ggcccagcgt
     7201 caccacgaac tgcagcccgc tgctgccgac gccggtgacc agcgtctgca gggccgggtt
     7261 gagtcccatc aggatgtagg tcaggccgcc catgatcgcg ccggtggtga gcccgcggcc
     7321 gaccagccac ggcgcggcga acagcaggac gatcagcggc agccacaccc cggcggcgaa
     7381 gcagaaggtg cgcagcaccg cgacccaggc gagtgcgcgc tcggcggccg cctgctcctc
     7441 gatgggctcc gcggcgagcg cggccgcgtg cccctcggcg ccggtcgcga ccacgtcccg
     7501 ggtggcggac agcaccgcgt tcgccgtgtc gcccacccgt tcctcggcca gcaccgtcgc
     7561 ccgctcgcgt gcggcggcca gccccagggt ggcgacgaac gcgccgaacc cgagtgcgaa
     7621 cggcgggagg atcaggccca cgatcaccgg gtcgatggac agcagcccca gcaccacgcc
     7681 ggccacggtg acggcgaacc cgcgggtcac cacgatgagc ccggcgaagg agtcgcgcac
     7741 gatctccacc tgacgcgtca cccgggccat cgccccgtcg tcgcggtggc cggcgacggc
     7801 gtgcgcgagc gctccgccga ccacccggcg gaggaggtcg tcgcggaacg gctcgaccag
     7861 atcgccgagg cggcggaaca cctgccgcga tccccacgcc ccgacgcagg ccgcgagcag
     7921 gaacgcgccc agccaggcca gcccggtcac cggccgcgcc gcgaggaacc cgtcgtccat
     7981 cgccttcgcg atcgccagac cggagatcgt cgtgggcagc gcttccggga ccgaccaggc
     8041 gaggagcgcg agcagcggcc gccggtgcag cgcccgcagc ccgaaccgga tctcccgctt
     8101 catccgaacg cctcccggta gcccgcgtcc tgccagagcc ggtggtgcgg cgcgacggcc
     8161 cgcacgcggc cggcgtcgag ccacacgacg cagtcggccc gggcggcggt cgagacgcgg
     8221 tgggtgacga tcaggcgggt gcggccgccg tcgtcggtca aggtgcggct gatctgcatc
     8281 tccgtgacca tgtcgaggct ggaggtcgcg tcgtccagca cgagcaggcg ccgcgcgtgc
     8341 caggcccggg ccaggccgag gcgctgggct tcaccaccgg acatcggcgc gtcggccagc
     8401 ggggtgtcgt agccctccgg atagcggctc acgaagtcgt gggcgtgggt ggcgcgggcg
     8461 gcggtcaaca ccgaggcacg gtcccgtccc gacccgatcg cgtccgccac ggtcgcgccg
     8521 accagcaccg ggcgttcgaa cgcggcgcac accgcggcgc gcaacgcttc gtggctcagc
     8581 tcccccaggg gaacgccgtc gagcagcacc tcgccctcgt ccgggtcgcg cagccgcgcg
     8641 gcgagcgccg cgagcaccga cttgccggcg ccggagtggc cgaccaccgc cacggtcgcg
     8701 ccaccgggca cggtcaggtc gacgtcgtcg agcagggtgg tcccgtccga ccggacggtg
     8761 acgtggcgga attccagccg gccagtgccc tcgggcagcg cccgcgagcc gtactcgacc
     8821 gcgggcacgg tgagcacctc ggcggcgcgg gcggcgccgg cccgcgccct ggcgagctgc
     8881 ccgaacaccc cggcgagccc gccgagcccc gcgccgagca ccgcgtaccg gctggccgcg
     8941 aacaggtccc cggcggtgat ccggccatcc accagcgcca gcccgccgac cgcgaggacg
     9001 gcgaccagga cgagcgggcc cgcgacggcg ccctgcgcgg ccgcccggga gagcacctgc
     9061 caggtctgcc tgccgtggcc gtgcagctcg ggaagcggtt cgagcacccg gctctcctcc
     9121 cgcccggccg tgccggcggc cgcgatggtc cgcgcccccg ccagcgactc cgcgagccgg
     9181 gccgcgatcc ggccctgggt ccgctggtag gcggtgaaga ccgcggtgct gcggacggtg
     9241 aaggcacgca gcaccgcggc gacgaccgcg agcccggcga cgaacgcgac cgccagccac
     9301 gggtcgatga cgaccagcag caccaggctc ccggccggcg gcagtacggc ggccaccacg
     9361 gtcaccacgc tcggtccggc ctgtgcggcg tcgacggcgt tgccggagat ccggctcacc
     9421 aggtcaccgg tgtcgaagcg gcgggcgcgg tccggcccca tccggagcac ctgccgcacc
     9481 aggcggttgc gcagccacgc ggtcgtgccc gcgacgcagg cgatgcccgc ggaggcgtcg
     9541 atcaggtcgg cgaggatgcc caccacgacg agggcggccg ccagcagcag ccagcggccg
     9601 ctgtcgtccc cggccacgat cgcgtcgacc gcgcgcccga gcaccgcggg cagcgccagc
     9661 gtgctcagcg tgccggccag cgcggcgaaa ccgatcaccg gcagccatgc gccccctcgc
     9721 cgcacgatcg caccgaaggt cgtggacacg taccctcctc ctcaaggccg cggccccgga
     9781 cgaacgccag tcgtccggga ccgcggctgc acccgggatc agtggcagat caggacgctc
     9841 aggccactgg tgccgccgca gagggtgacg ctcaggttgc tcgggcagct cttgccgctc
     9901 gcgctgctgc cgccaccgcc ccactccggg gccgcgcttt ccatgccttg caggtcgaga
     9961 agggccattt ctcctccttg gagagtgggt tggacgggga tcaccctgcc gcgccgactg
    10021 ccggcgcgga ggtctgtggg gccggggcgg gcgcgagcag cggcaggtgg accggcgggt
    10081 cggccagcac cgagcccagc gccaggagca ccccggcggt gccggtggcg aggtccatcg
    10141 acaggcgcag cagtccggtg ccggggaacg ccgtgccacc gccgaaggga agcgcgtgcc
    10201 aggccagcgc gcgcacctgc ctggcgaccg acgggtcgcg cggcggatcg ggcgagcgcc
    10261 cggcgaggta gagcaggatc ccggcgcggc cggagaacag cccgggcagg atgtacatcg
    10321 gcgactgcgc ggcgagctgg atgcgccggt tcgcctcggc gaactcggcg tcgtcgcggc
    10381 gcgcgaggaa ctcgtcgagc accaggccga tgccgacgct gccgacgtcc aggtagggca
    10441 tggtgcgcca gccctcgttg acctccagcg cgccgctgtc gcggacgacg cactgccgga
    10501 ggtcctgccg cagcgcgatc gcggcgcggt cgagcagggc ggtgtcgccg gtgtcgtcgt
    10561 aggcccgcag gagcagcagc gccttgcccg cgccgccgcg catcaggccc gcgaaggagc
    10621 cgtcccggcc gctgatctcc gggccgtcgg cggcgtcacc gacccgctcg gcgaccagtt
    10681 ccaccgcccg gtgcgcggcc cgccggagcg tcggatcgcc ggtgcggccg gcgaagtgca
    10741 ggaggttcag gccggcgccg gccagcccgc cgcccaggtc cggcccgagc gcttcccagt
    10801 tctcgcgcag gcagatgtcc agcacgtcca gcgcctgctg ccggtatccg aggtggtcca
    10861 gggcgaaggc cgcgccgtgc agcccgtcga acaggccgag ccgggtgccg cccggcgggt
    10921 tggtcgcgcg gtcgacgagc cacttctcga agacggggct gggatccgca ccggtcgcgg
    10981 acaacgcgta gagcaccccg gcggcgccgt gggccaggcc gatgccgccg gtggcgaact
    11041 gctccggatc gccggggaag agccggtcgt cccgctccgg cgtcgcgctc gccacgatcg
    11101 cgcgcaccag gtcgtcgcgc agctcgggcc aatccgccgg gtccggttcg atccgcgggt
    11161 gcggcaggtg cggggtaccc ggcggcacga tcacgtcgac cgcctcggtg aggtagctcc
    11221 gcggcaccgg gaagtgctcg gcgatgatct cggcgaactg ccgcgccttc acccggtgca
    11281 ggccgaacag gtaggtcatc ggcaggaaca gcgccaggcg caggcacgcg agcgcgtagc
    11341 ggtcgatgtc gaaaccggtg acgctgcgcg gcgcggcgaa cccctggttg cccaggcccg
    11401 gccgggccgc ctccgcgacc ggggcggcca cctcgaagtc gagcagccgg atcgtgccgt
    11461 ccgcgcgcac catgacgttg aacaggtgca ggtcgccgta gacgatcccg cgctcgtgca
    11521 ccgcacgcat cgtctcttcg atctgccgct ggatccccat ggcccagtcg gtgaagtcgc
    11581 ggtagtcctc cggtccagca ctcgggtcga tgagcgggta ccggcggacg atcgccttgc
    11641 ccagcacgtc gccctcgacg tactccatca ccaggaaccg gtgctcgccg agccagaaca
    11701 ggtcgtgcac ctcggggatc cccgggatgc ccgccagccg ccgcaggatg tcgtgctcgt
    11761 gctcgacgcg ccgcaccgcg tcgtggcccc acgcgtcgag tcccgcgtgc gggcggccct
    11821 ccttgaggac cacctgggcg ccggtgcggt tgtcccggcc gacgtagatc ccgccgccgt
    11881 tggagaagtg cacgactcgc tcgatcgtgt agggcaggcc ggcgacggtg accgcgttgc
    11941 gggcttccag gtgcggcgcg aggaagtcgg ggagcgtcac ccacggcggc acgtggaaca
    12001 ccggcccgcg gcggtccggg accagccggc cttcgccgtc cgcgatggcc ggcaccacgt
    12061 caccgttttc ggtgaccatg taccggttga cgaacgcgcc gtagcgcacg aacagcggcc
    12121 cgcgccccca gcgcaggtcg ctcaggatgt aggggttcgg ctcgccgtcg agcgtctcgc
    12181 cgagttcgcg caggatcgtc tcgcacgcgc cgagatcggg cgggtagatc gtcaccagct
    12241 tgccgctgta cccgcgcggc gcgtacttgg agacccgggc ggtcagcgcg gcgggcgagc
    12301 gcaggaactt gaactcgatc cgccgcggca cgcagtagtc ccacaccgcg tcgaggatct
    12361 tctcggcgtt gcccggcgtg gcggagacgt ggatcttcca cccctgcgcg ggcagcccgg
    12421 tggctcccgg gtcgagcacg aaccagtcgt cctgctcgta ccggcgccag ccgtcgggca
    12481 ggggcagccg cgcggtggcg aaggacgggc cggcggtgcg ctcggagtgc atggcgtcgt
    12541 agaacgacga gtcggccatg cagaatcgct cgtactcgtc catgccacct cgcttggtcg
    12601 ccacggcacc gccgggcaca agctaggtgg caggtcttcc ggtcgcctta gtctccgctt
    12661 agggtccgct ttggcttgac gcgaacgaaa ttcagaccga gctgccgccg atgcggcgga
    12721 tgatccgggt gacgatggac gagaccacca gccagaagat cgccgcgatg ccgtagttca
    12781 ccaggacccg cagcttctcg tcggccggct cgaacaggtc cttgaagccc agcgccagac
    12841 cgtcggacca gtcgcgcacg aacgagacga tcccgttgtc cgggttggcg ccgccgacca
    12901 cgaagatcac gtgcagcacc aggatcagcg cgaagatcag gccgacccag cggacgatgc
    12961 ccgcgatgag cccgatcgcc tggtccttca cgcgccccca cggcacctgc cgcttggggc
    13021 gcggcggctc gtcttcgtcg acgtcgctct tgcgcttctc ggcgtgctcg gccatgccgc
    13081 cgagtttccc acgcccggcc gcgcttggct acctgccagt aaccgagggg gtatcgaccg
    13141 ggtcactttt caacatcatc acgaccgggc tacagtggat ccgtggcgcg tgctctcctg
    13201 cttcgctgcc gcgacggggc ctgatcctga ccggcccccc gtcgcggggc ttcgtcacgc
    13261 cgccggtcgc ccgatcaccc ggcaggagag tttcccagca atgaccagct ccgatcccac
    13321 cgcgagccgt atccgcaagc cgtcgcgtcc cgcccccgcc gaccagcccg cgtggaaccc
    13381 gcagcgcggc agttcgatgc cggtccaccg ctaccagccc tggtacaagc tggtggagaa
    13441 catcgagctg cccgaccgca cctggccgga caagcgcatc gagcgcgccc cgctgtggtg
    13501 cgcggtcgac ctccgcgacg gcaaccaggc cctgatcgac ccgatgtcgc ccgcccgcaa
    13561 gcgcaagttc ttcgagctgc tcgtgcgcat gggctacaag gagatcgagg tcgggttccc
    13621 ggccgcgagc cagaccgact tcgacttcgt ccgcgagatc atcgaggacg gcgcgatccc
    13681 ggacgacgta cgcatccagg tgctgaccca gtgccgtccc gagctgatcg agcgcacctt
    13741 ccagtcgctg gagggcgcgc cgcaggcgat cgtgcacatc tacaactcga cctcgatcct
    13801 gcagcgccgc gtggtgttcc gcgaggagcg cgagggcatc aagaagatcg cgctgcaggc
    13861 cgccgacctg gtggtggagt acgcgcagaa gtactccgac accgacttcc gcttccagta
    13921 ctcgccggag tcctacaccg gcaccgagct gtcctacgcg gccgaggtgt gcaacgcggt
    13981 caccgacatc tggcagccga ccccggatcg cccggtgatc ctgaacctgc cggcgacggt
    14041 ggagatggcg acgccgaacg tctacgccga ctcgatcgag tggatgggcc gcaacctgga
    14101 ccgccgggac gcggtgatcc tgtcgctgca cccgcacaac gaccgcggca ccggcatcgc
    14161 cgccgccgag ctgggctacc aggccggcgc ggaccgcatc gaaggctgcc tgttcggcaa
    14221 cggcgagcgc accggcaacg tcgacctggt cgcgctgggc atgaacatgt tcagccaggg
    14281 catcgacccg cagatcgact tctccgacat cgacgagatc aagcgcaccg tcgagtactg
    14341 caaccagctg ccggtgcacg agcgcacgcc gtggggcggc gacctggtgt tcaccgcgtt
    14401 ctccggcagc caccaggacg cgatcaacaa gggcttcgac gcgctgcacc gcgccgcgga
    14461 gaaggccggg gtgccggtcg acgagttccc gtgggaggtg ccgtacctgc cgatcgaccc
    14521 gaaggacgtc ggccgcagct acgaggccgt catccgggtc aactcgcagt cgggcaaggg
    14581 cggcgtcgcc tacatcatga agaccgagca ccagctcgac ctgccgcgcc gcctgcagat
    14641 cgagttctcg caggtcatcc agcgctacac ggacagcgag ggcggcgagg tcgacccgcg
    14701 cacgatgtgg gacgcgttcg cgaaggagta cctggagccg cagacgccgc tgcagctgat
    14761 cagccagcac gtcaccgcga acggcgacta ccagctgcgc gcgacggtgc gggtggacgg
    14821 cgaggaacag gagatcaccg gctccggcaa cggcccgatc gccgcgttct tcgacgccct
    14881 gtcgaccgtg gggtacgacc tgaggctgct ggactacagc gagcacaccc tgacccccgg
    14941 cgacgacgcc cgcgcggcct cgtacatcga atgcgccatc ggcgacaagg tgttctgggg
    15001 catcggcatc gacccgtcga tcgtgacggc gtcgctgcga gcggtcgtct ccgcggtgaa
    15061 ccgcgcgcac cgctgacgca cgaaggccgg ccgctcccca cgggggcggc cggccttttt
    15121 cgttcagtgc gccgcggccg agaacatccc gggctggtag gagccgccct ggttgcggac
    15181 tatcacgttc atccggttgg ccgcgttgat catcgccacc agggtgatga gcgcggcggt
    15241 ctggtcgtcg tcgtagtgct tgcgcacctg ggcccacgtc tcgtccgaca cgccctcgtg
    15301 cgcgtcggcg aggcgggtgc cctcctcggc cagcgcgagc gccgcccgct cggcctcggt
    15361 gaacaccgtg gcctcgcgcc agaccgcgac caggttgagc cgcgtcgcgg tctccccggc
    15421 ggccgcggcc tccttggtgt gcatgtcgac gcacagcgcg cacccgttga tctggctggc
    15481 ccgcaacgac accagctcct gcgtggactg cggcagcgcc gtcgactgca gcaccgcggc
    15541 cacccccgcg aaccgcttcg ccagcttcgc cccgacctcg ttggccatca ggttgaaccg
    15601 ggtttccacc acttcgtcct cctcggagtc gctctcgtac gaccacaagg caccggccgc
    15661 gcgccggatg tgacagtgac ggccgtcacg gcttggtcgt caccgcggcg gcctcggcgt
    15721 gcaggagctc cagcaccgtg gcgaccggcg ggcgcgtgcc ggcgccggtg cgcaggacgg
    15781 cctcgatcag ccgcgccgcg cggataccgg ccagcggccg ccgcacgatc cgccgcgacc
    15841 aggtcccggc cagcgtgtag cgcggcagca gcgcgatgcc gtgcccggcc gcgaccaggg
    15901 cctcgatgat ccggaagtcg ttgatgcgct gcttgacccg cggccgcacc ccggtgcgca
    15961 ccgcgagcga ccgcagcacg tcgtcgaccg ggaagccgac gtccaccgag atccactgct
    16021 ccccggccag ctcggtgagg tccacgcggc ggcgccgcgc gaggtggtgg ccgagcggca
    16081 gcgccacgtc caacggctcg cgcagcaggt gcaccacgtc cagccgggcg gacgggaacg
    16141 gctcggcgtg ctcgtcccgg tgcgtgacca cgatgtcgaa gtcggcgacc agctccggca
    16201 cctcggccgg cgtcatgtcg acgtcgcgca cctccacgtc caggccctcg acctcggcga
    16261 accggtgcag cagcccgggc agcaacatca acgcggcgga cgggaagatc gccacccgca
    16321 cccggccgcg tggcaggctg cggaacacgt ccatctccgc ctcggcgcga tccatcgcgg
    16381 cgatgacctc gtccgcccgc accaccagcg cccggcccgc gtcggtgagc cgcagcccgc
    16441 gaccggccgg ttcggtgagg accagcccga cctccgcctg cagcgcccgg agctgctgcg
    16501 acaccgcgga cggcgtgcag tgcagggcct tcgccgcggc cgtcacgctg ccgcgatcgg
    16561 cgaactcgcg cagtacccgc aaccggccga tgtccatgaa gcaacgctac acagtaggtg
    16621 caaacaatct cgattgtcct tcatagttgt ggcaggcaag ctgaacaagt gcctactcgc
    16681 gaccgcctcc tcgccttgtt cgtcgtcgtc ctgtggggcc tcaacttcat cgcgatgcac
    16741 ccgatgctcg accacttccc gccgctgttc gccggcgcgc tgcgcttcgc ggtgatcgcg
    16801 gtcccgacga tcctgttcat cccgcggccg aaggtgaagc tgcgctggct gatcggcttc
    16861 gggctcgggt tcggcaccgg gcagttcgcg ttcctgttcc tcgcgctgac caacggcatg
    16921 ccgaccggcc tggcgtcgct ggtgctgcag gcctcggcgc cgttcaccgt cctgctcggc
    16981 gggatcttcc tgcgtgaacc gctgtccgcg cggcagctga ccggcatcct ggccgcggtc
    17041 gccggcatgg gcgtgatcgc ctggcaccgc gcggagaacg ccgtgctgct gccggtcgtg
    17101 ctcaccctgc tcggcgcgtt gtgctgggcg atcggcaaca tctgctcgcg tcaagcgaag
    17161 ccggagaacc cgatccacct caccctgtgg atgtcggtca tcccgccgat cccgatgttc
    17221 gccctgtcca cggtcttcga gggcccggcc gtgcagtggc actcgctggc cacgctgggc
    17281 accggcgagg gcctgctcgg gctggccggg ttcacctacg tcgtgctggt cggcacggtg
    17341 ctcgggtcga gcatctggac cgtgctgatg cgccgcaacc cggccaacgt ggtggcgccg
    17401 ttctcgctgc tcgtgccggt cgtcgggatg tccgcggcgt tcttcgtgct cggcgagacc
    17461 ccggcgctgg tcgaggtgct ggccggcctg gtggtggtgg ccggggtgct gttcggctcg
    17521 ctgccgaggc gtcagcggtc ggccggcgcg ctctccgccg agctggtctc ctcgtgacgg
    17581 cgggccatcc gcttcttgat caccaggctg accaccacgc ccacgacgac ggcgaccgcc
    17641 agcgcgaggt aggagaaccg ggacagccac ttctccgcga ccacgccgag cgagtacacc
    17701 agcgccgtcg tgccgcccgc ccagacgatg ccgccgagcg cgttggcgag caggaaccgc
    17761 gggtagtgca tgtgcagcga cccggcgagc ggaccgcaca ggatgcgcag aatcgcgacg
    17821 aagcggccga agaaaaccgc ccacatcccc cgtttccgga acattcgctc ggcggccgcc
    17881 acgtgcgacg gtccgaaatg cttggggaac ctccgcccgg cccagtcgaa caggcgctgc
    17941 ccgcccttgc gcccgatcag gtagccgatg ctgtccccgg cgatggcgcc gccgctgccg
    18001 acggcgccga tcagccaggg gttcagcccg tcgtggtgcg aggccaggag agccgcgctg
    18061 accagcacga cctctcccgg caacgggatc cccaggcttt cgcacccgat caccagcccg
    18121 accgcgaggt agacggccag cggcgggatc gtctccagcc acgcgtcgat gtgcacgaaa
    18181 aaccccctcg ggtaccccgg cggaattgcc gccagggtac cccggtcagg gctccagcat
    18241 ttcggccacg gaagcggcct gcggaatagc cgtatcgggt gacaactgcg cggtgaccaa
    18301 ttccggtttc acctcgtgcg gggtgatccg gccggcctgg atgtcctccg cccagtggca
    18361 ggcgacccgg tgcccggcgc cgagctcccg cagcgcgggc cgctcggtgt cgcacttggt
    18421 ctcctgccgc cacgggcagc gggtgtggaa ccggcagccc gacggcgggt tggccggcga
    18481 gggcaggtcg ccggcgagca ggatctgctc ccggccgtcc tccaccaccg ggtccggcac
    18541 cgggatcgcc gacagcagcg cccgcgtgta cgggtgcagc ggctcgtcgt acagggtctc
    18601 cgagtcggtc tcctcgacca gcgagcccag gtacatcacg ccgatgcggt cggagatgtg
    18661 ccggacgacc gccaggtcgt gggcgatcac caggtaggtc aggcccagcg agtcctgcag
    18721 ctcctcgagc aggttgatca cctgcgcctg cacggagacg tccagcgcgg acaccggctc
    18781 gtcggcgacg atcaggtccg gttccacggc cagcgcccgc gcgatgccga tgcgctggcg
    18841 ctggccgccg gagaactcgt gcgggtactt ccgcagcgaa ctctccggca ggccgaccgc
    18901 gttgagcagc tcacgcaagc gcttgcgcgt gctgtcccgg tcccggtcca ggccgtgcgc
    18961 ccgcatgccc tcgatgagga tcgactcgac cgactgccgc gggtcgaggc tggacagcgg
    19021 gtcctggaac accatctgca tccgccgccg catcttccgc agcgactcgc ccttgagcgt
    19081 ggacaggtcc acgccgtcga acaccgcgcg gccaccggtc ggctcgacca gccgcagcag
    19141 gctgcggccc agcgtcgtct tgccgcaccc ggactcgccg accaggccgt aggtctcgcc
    19201 acgctggatc tccaggtcga ccccgtccac ggcgtagacg tgaccgatcg tgcggtccag
    19261 caccaagccc cgcttgatcg ggaagtgcac ctgcatgcct tccacgcgca ccagcggttc
    19321 ggacatcagc gcaccccctc gcccgccgcg accggacggt ccaccggatt gtggcaccgc
    19381 agcatcccgc ccgtgtcggg ttcgagctcc ggcgtgacct cgcggcacag ctcgagcgcg
    19441 ttcgggcagc ggggcgcgaa cgcgcacccc tgcgaccacg ggatgttgtc ggagaccgac
    19501 cccttgatcg gcaccagctt ctcgccgcgc ggcgcgtcca gccgcgggat cgaggcgagc
    19561 agcccgtgcg tgtaggggtg ccgggcggag gcgaacaacg cgtgccgctc cgcccgctcg
    19621 accacccggc cgccgtacat gacgttgacc tcgtcgcaca gcccggcgac gacgccgagg
    19681 tcgtgcgtga tcatgatcag cgcggtgccg gtctcgcgca ccagctcgga cagcagcgcc
    19741 aggatctgcg cctggatcgt cacgtccagc gcggtggtcg gctcgtccgc gatcagcaac
    19801 cgcggacggc aggccagcgc gatcgcgatg agcgcgcgct ggcgcatccc gccggagagc
    19861 tggtgcgggt actccgacag ccgccggttc gggtccggga tgccgacgcg gtccagcagg
    19921 tccgctgcct ccacccgggc ttgtttgcgt tccatcttgc ggtgccgttc caggacctcg
    19981 gtgatctgca gaccgatcgg gatcaccggg ttcagcgacg acagcgggtc ctggaacacc
    20041 atgccgaggt cgcggccgcg ccggtcgcgc agctgccggt cggacaactg gagcaggtcc
    20101 gtgtcctcga acatgacctc gccggtgacc cgcgcgccgc gcttgggcag caggcccatg
    20161 atcgccagcg cggtcaccga cttgccgctg ccggactcgc cgaccaggcc gaccgtgcgg
    20221 cccggctcga cgtcgaaact gaccccgtcc accgcggtga acggccgggt tcccttgcgg
    20281 gagaagacga ccgacaggtc gcgtacttgc aggagactca acgcgctacc gcctgttctt
    20341 cgggtcgagc gcctcgcgca gcgactcgcc gagcagcgtg aaccccagcg ccaccacgac
    20401 gatcgcgatg gccgggtaga acgccaggct cggtttgacg tccagcaggt tctgggcctg
    20461 ggccagcatc agcccccact cggcgcggct gggatcgttg tcgccgaggc cgaggaacga
    20521 cagcgccgcc acgtcgatga tcgacgtcgc cagcgtcagc gtggcctgca cgaccaccgg
    20581 cccgagcgag ttcggcagca tgtgccggaa cacgatcgtg ctgcgccgga cgcccagcgc
    20641 ggtcgccgcc agcacgtggt cgctggatct ctgcgacagc atcgcgccgc gcagcagccg
    20701 ggcgaagatc ggcacgctca ccaccgcgac cgcgatgatg accgtccact gtgtcccttg
    20761 cgagaacagc gccgcgatcg agatcgccag cagcagcgag gggatcgcga gcaggatgtc
    20821 ggtgaaccgc atcaacagcg tgtccaccca gccacccagc gcgccggcca gcccgccgat
    20881 gagcatgccg accgtcagcc cgatcagggt ggcgaccaca ccgacgatca gcgtctgctg
    20941 cgcaccgacc agcaggcggg agaagaagtc gtacccgcgg tggtcgctgc ccatcacgaa
    21001 cccgtccatc gggccgggga tgaagtccgg ccgcaggttc acgcgcagct cgtcgtaggg
    21061 gacgtagggg ttcttcggcg ccaggaacgg ggccaggatc gccagcagca cgaacaggac
    21121 ggtgatgacc gcgccggtga tcgccaccgg gctgcgcgcc atccgccgga ccgcgtccgc
    21181 cgcgaggctg gtgccgccgg cctcggccag gtcgtcgatg cgttcggcct tgcgccgcaa
    21241 catggaggtc atcgcacccg caccctcgga tcgatgatcg catacgagat gtcgaccagg
    21301 aggttcacca ggacgtacac cacggcggcc agcagcagca acgcctgcag ccgcgggtag
    21361 tcccggcgtt cgatgccctg cgccagcagc gcgccgacgc cgttccagtt gaacaccttc
    21421 tcggtgagca cggccccggc gagcagcaga ccggtctgca gaccgatcgt ggtggacacc
    21481 ggcaggagcg cgttgcgcag cacgtgccgc tggcggatcg tgccggtggt caggcccttg
    21541 gactccgcgg tgcgcacgaa gtcctcctgt tgcacgtcca gcaccgaggc gcgggtgatc
    21601 cgcacgatca ccgcgaacgg gatgctggcc agcgcgatcg cgggcaggat caggtgcttg
    21661 atcgcgtccc aggtggcgtc cagctcgccg gtgagcaggc cgtccagggt gaagaacccg
    21721 gtgatgtggg tggcgtcgat ggtgacgtcc tggcgcccgg acggcggcag gacgcccagc
    21781 ttctgcgcga acacgtactt gagcagcaca ccgaagaaga acaccgggac cgcgacgccg
    21841 accagcgtgg tgagcacggt ggcgttgtcc aggagccggc cccggtaacg cgcggcgagg
    21901 tagcccatcg ggatgccgaa cccgaccgcg aggaccagtg cggccagcga cagttcgacg
    21961 gtcgcgggga aggcccgccc gatctcggtg agcaccgtgt cgccgctgat cagggacgag
    22021 ccgaagtcac cggtgagaac gcggccgagg aacttgaagt actggacgaa gatcggttga
    22081 tccaggccca gcaccgagtt cagggacgcg accttctccg gcgtcgcctt gtcgccgagc
    22141 agcgcggtgg cggggccacc gggcagcagg cggagccagg cgaagaccag gatggagagc
    22201 acgaggagcg tcgggatcgc ttgcagcaac cgacgaatca cgaatcggag catgtgttgt
    22261 gcctttgact ccgcaccacg gcgggaaagc acgcgcggcg cgctttcccg ccgtcgatgg
    22321 cggaactcag cccttgttgc ccttggtgac cgtgtagaag cgctcgtcgg tcagcggggt
    22381 cgggaccagc ccctggacgt cggaccggac cacgatcccc ggcggcgacg acgagagcgg
    22441 caccgcgggg acgtactgcg agatcagcac gctggcgttc tcgtaggccg ccttcttggc
    22501 atccggggtc gtctgcgcgt ccgcggtgga cagggcgttg aagatctgcg ggttgtcgaa
    22561 cccgaactcc ggcttgggtc ggc
//
