LOCUS       NZ_BNAU01000002        27025 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000002
VERSION     NZ_BNAU01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1346353)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 955612
            Orig. end                         :: 982637
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27025
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="3"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..27025
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27025
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:17025]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17025
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(697..1632)
                     /locus_tag="IE290_RS12860"
                     /old_locus_tag="GCM10017786_26210"
     CDS             complement(697..1632)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416724.1"
                     /locus_tag="IE290_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26210"
                     /product="SMP-30/gluconolactonase/LRE family protein"
                     /protein_id="WP_191244763.1"
                     /transl_table=11
                     /translation="MREIASGLRFPEGPVALDDGSVLVVEVERGTLSRVWPDGSVTVVA
                     DCGGGPNGAAIGPGGAIYVCNSGGFTWHRRGGVTMPGEQPPDYRGGCIQRVSWDGVVTQ
                     LYTSVDGRPLRGPNDLVFDAHGGFYFTDLGKDRPRDSDRGGLYYARADGSGIEEIAYGF
                     TGLNGVGLSPDGSRVYAAETVTGRVWFWNVDGPGRISRPAGAVGPAGAKLLHGFGGYQL
                     LDSLAVDSAGNICVATIITGGISVLSPAGELLEVVRPPSPDRFVTNICFGGPDLRTAYI
                     TSSGVGKLWAAEWPRPGLRLNHADAAPADR"
     gene            complement(1629..2924)
                     /locus_tag="IE290_RS12865"
                     /old_locus_tag="GCM10017786_26220"
     CDS             complement(1629..2924)
                     /EC_number="2.7.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416723.1"
                     /locus_tag="IE290_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26220"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_191244764.1"
                     /sec_met_domain="APH (E-value: 5e-37, bitscore: 124.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLAEALGRRLGAKITGLRRLSGGASRETWAFTAEPGGRLVLRR
                     DPPGECRPEEMAREAALIRAAHEAGVPVPRLVDHGADLLGSPYLITEHVDGETIPRRLL
                     REPEFADVRPKLAAELGRVAARIHAMTAVPGLSSVDPLHSLVELYDSLGQPLPSLEIGL
                     RWLRAHRPEPAGDTVVHGDFRNGNLIVGPDGLAAVLDWELAHRGDPLEDLGWLCVKAWR
                     FGSPLPVGGFGSREELLDGYAEVAGFRPDPAAVHWWEVFGTVRWAVLCLRQADRHLSGR
                     IRSVELAAVGRRVCEQEHDLLTALGVPAVPVDAAADPVPDLHGRPSAAELVEAVGEFLR
                     AEVVPGTEGRLSFQARVAANVLAMVSRELRYGASQEARHGERLAALGFSSHAELARAVR
                     SRAVVVADVVGVVRADVTDRLLVANPKYLESV"
     gene            complement(2921..4174)
                     /locus_tag="IE290_RS12870"
                     /old_locus_tag="GCM10017786_26230"
     CDS             complement(2921..4174)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416722.1"
                     /locus_tag="IE290_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26230"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_191244765.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 9.7e-12, bitscore:
                     41.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1e-20, bitscore:
                     70.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.8e-42, bitscore:
                     140.3, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFELPAALRQLLTDLDQFLEDEIWPLQRQDDNERFFDHRREYAR
                     TDFEAGGTPRREWEELLKEMFRRADRAGWLRYGLPKSVGGGGGSNLDMAVIREHLAAKG
                     LGLHNDLQNESSVVGNFPFVHMFLAAGTPEQQSEFVEDMITGRKRVAFGLTEPDHGSDA
                     TWLETTAVRDGDDWILNGAKRFNSGLHSATHDVIFARTSGEGGDPRGITAFIVPTDTPG
                     FSVDFHWWTFNMPTDHAEVTLTDVRVPGAAVFGEVGGGLALAQHFVHENRIRQAASGVG
                     AAQYCIDRSVDYARARRTFGRPLAERQAIQWPLVELQTEAELVRTLVRKTAWELDHTDH
                     MLISDKVSMCNYRANRLVCDAADRAMQVHGGLGYTRHTPFEHIYRHHRRYRITEGAEEI
                     QMRKIAGYLFGFAGPDKR"
     gene            4222..4989
                     /locus_tag="IE290_RS12875"
                     /old_locus_tag="GCM10017786_26240"
     CDS             4222..4989
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (12-173). E-value: 2.3e-15.
                     Score: 48.9. Matches aSDomain:
                     nrpspksdomains_IE290_RS12875_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416721.1"
                     /locus_tag="IE290_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26240"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_191244766.1"
                     /sec_met_domain="adh_short (E-value: 3.2e-32, bitscore:
                     108.2, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.8e-31, bitscore:
                     105.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNPFDLTGHASVVTGGNSGIGLAMAGALAAAGADVAIWGTNTER
                     NDAAVAELSRHGTKVLAVRCDVGDEDEVESAMARSVEALGRLDSCFVNAGVGGAGSRFT
                     ETSLEEFRRVTRVDLDGAFLTLRAAARVMLAQGTGGSLVGTSSVAAVQGQPRGQAYAAS
                     KAGLTAMIKSIAVELARHGIRANAVLPGWVHTPLAAPALDSEGFQRRVLPRMPVGRWGR
                     PDDFGALAVYLASPASAFHTADTITVDGGYLSF"
     CDS_motif       4258..4323
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS12875_0001"
                     /evalue="9.70E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE290_RS12875"
                     /protein_end="34"
                     /protein_start="12"
                     /score="15.0"
                     /tool="antismash"
                     /translation="VVTGGNSGIGLAMAGALAAAGA"
     aSDomain        4258..4740
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12875_PKS_KR.1"
                     /evalue="2.30E-15"
                     /label="IE290_RS12875_PKS_KR.1"
                     /locus_tag="IE290_RS12875"
                     /protein_end="173"
                     /protein_start="12"
                     /score="48.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVTGGNSGIGLAMAGALAAAGADVAIWGTNTERNDAAVAELSRHG
                     TKVLAVRCDVGDEDEVESAMARSVEALGRLDSCFVNAGVGGAGSRFTETSLEEFRRVTR
                     VDLDGAFLTLRAAARVMLAQGTGGSLVGTSSVAAVQGQPRGQAYAASKAGLTAMIKS"
     gene            complement(5003..5881)
                     /locus_tag="IE290_RS12880"
                     /old_locus_tag="GCM10017786_26250"
     CDS             complement(5003..5881)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (11-226). E-value: 6.7e-48. Score:
                     155.1. Matches aSDomain:
                     nrpspksdomains_IE290_RS12880_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416720.1"
                     /locus_tag="IE290_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26250"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_191244767.1"
                     /transl_table=11
                     /translation="MGGAVSYDEIIYEVSDGIATITLNRPARLNAFTLEMAHELVAAFD
                     EADADDSVRVVVVTGAGRGFCAGADLERGAGTFNKDVIGEVEGFGEIDGVPRDAGGAVA
                     LRIAACKKVVIGAFNGPAVGIGVTMSLPMDIRIASENAKFGFVFARRGILLEAASSWFL
                     PRVVGISQAMEWVATGRVFDAAEARAGGLVSRVVAPDELIPTALSIAREVADNTSAVSV
                     AVSRQLLWGMLGSPTPWDAHRADSRALLQLGAGKDAMEGVMAFLEKRSPNFPGRVSADY
                     PDGVPPFPGTP"
     aSDomain        complement(5204..5848)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12880_ECH.1"
                     /evalue="6.70E-48"
                     /label="IE290_RS12880_ECH.1"
                     /locus_tag="IE290_RS12880"
                     /protein_end="226"
                     /protein_start="11"
                     /score="155.1"
                     /tool="antismash"
                     /translation="YEVSDGIATITLNRPARLNAFTLEMAHELVAAFDEADADDSVRVV
                     VVTGAGRGFCAGADLERGAGTFNKDVIGEVEGFGEIDGVPRDAGGAVALRIAACKKVVI
                     GAFNGPAVGIGVTMSLPMDIRIASENAKFGFVFARRGILLEAASSWFLPRVVGISQAME
                     WVATGRVFDAAEARAGGLVSRVVAPDELIPTALSIAREVADNTSAVSVAVSR"
     gene            complement(5866..6648)
                     /locus_tag="IE290_RS12885"
                     /old_locus_tag="GCM10017786_26260"
     CDS             complement(5866..6648)
                     /NRPS_PKS="Domain: ECH (10-247). E-value: 7.8e-52. Score:
                     167.9. Matches aSDomain:
                     nrpspksdomains_IE290_RS12885_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416719.1"
                     /locus_tag="IE290_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26260"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_191244768.1"
                     /transl_table=11
                     /translation="MTDQPVLLDRAGAVLTVTLNRPHRKNAIDLPMWDGLYQAFHDAER
                     DDDVRVVVVTGAGGDFCGGADLSTDVEDHPLTRMHRVNDVALALNEISKPTIAKVDGVA
                     VGAGWNLALGCDLVVATERARFSQIFARRGLSLDFGGSWLLPRLVGLQQAKRLALRAEM
                     IGAAEAHDLGLVTWTTPADELDSFVDSLAAELAEAPPIALALSKRLLEEGASRTLREAL
                     EGEARAQTINFATEDAPAAFEAFLDKTEAKYTGRWAVR"
     aSDomain        complement(5908..6618)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12885_ECH.1"
                     /evalue="7.80E-52"
                     /label="IE290_RS12885_ECH.1"
                     /locus_tag="IE290_RS12885"
                     /protein_end="247"
                     /protein_start="10"
                     /score="167.9"
                     /tool="antismash"
                     /translation="AGAVLTVTLNRPHRKNAIDLPMWDGLYQAFHDAERDDDVRVVVVT
                     GAGGDFCGGADLSTDVEDHPLTRMHRVNDVALALNEISKPTIAKVDGVAVGAGWNLALG
                     CDLVVATERARFSQIFARRGLSLDFGGSWLLPRLVGLQQAKRLALRAEMIGAAEAHDLG
                     LVTWTTPADELDSFVDSLAAELAEAPPIALALSKRLLEEGASRTLREALEGEARAQTIN
                     FATEDAPAAFEAFLD"
     gene            complement(6645..7700)
                     /locus_tag="IE290_RS12890"
                     /old_locus_tag="GCM10017786_26270"
     CDS             complement(6645..7700)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981334.1"
                     /locus_tag="IE290_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26270"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_191244769.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.1e-19, bitscore:
                     64.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-23, bitscore:
                     80.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLVLDTEQQQLRSTVRKLLADHNNVRSVVDGDDTYDAALWRHLA
                     ELGLTGLVVPEEQGGAGAGHVERCIVLEELGRALAPVPFFASAVLAVDALAALGDTEVL
                     PALAAGEKIGALAVSPEWGPAPVSATERDGGWVLDGHVPFVISGDVADVFVVCTESGWF
                     VAEDARRTALTTLDPTRGQARLDFAGTPARRLDTADPAAVLEKVRDLASVALAAEQVGG
                     IAKVLETTVEYAKVRVQFGRAIGSYQAVKHACADLYSTSERAESLLRHAAWAADHDPDA
                     LPLAAATTQVFTGPAYFAAAASGLQLHGGIGYTWEHDAHLYYKRAKSSELLFGGHDEQL
                     ARLAGRLDGAS"
     gene            complement(7714..8886)
                     /locus_tag="IE290_RS12895"
                     /old_locus_tag="GCM10017786_26280"
     CDS             complement(7714..8886)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981333.1"
                     /locus_tag="IE290_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26280"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_191244770.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.4e-24, bitscore:
                     81.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.5e-23, bitscore:
                     77.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-17, bitscore:
                     60.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEFREKVRAWLAEHVPGDEELETAKRFQAALYDAGLAGITWPKE
                     FGGQGLTAAEQQIFDQESANYDLPNSVFRIGMGMCGPTILDLGTPEQKARYIPPLLRGE
                     EIWCQLFSEPGAGSDVASLQTRAVRDGDGWVVNGQKVWTTVAHLADFGALLARTDPDVP
                     KHQGLTMFLIDMHDPAVTVRPLKDMTGRAPFNEVYFENLRLPADAVLGQVGQGWLAAVT
                     MLGHERVSIGGFVRKRHDPLAHANLAETARRYGRDSDPVVRAELAKLYAAERALALFNT
                     RLRQEAEAGSPPGARGSVAKLAGAQLQQQAVAVAGLIAGPRATAWEPGDAAGDELALAI
                     NQTPSSSIAGGTDQIQRTIIGDRILGLPREPVVDRDVPFRELRVGTQRPA"
     gene            complement(8883..10016)
                     /locus_tag="IE290_RS12900"
                     /old_locus_tag="GCM10017786_26290"
     CDS             complement(8883..10016)
                     /EC_number="2.3.1.16"
                     /GO_function="GO:0003985 - acetyl-CoA C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416716.1"
                     /locus_tag="IE290_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26290"
                     /product="acetyl-CoA C-acyltransferase"
                     /protein_id="WP_191244771.1"
                     /transl_table=11
                     /translation="MRDAVIVEAVRTPVGKREGGLSGVHPVDLSAHVLRGLAERAGIDP
                     AEIDDVVWGCVSQAGEQTGDIGRNAVLAAGWPESVTGVTVDRQCGSSQQSVHFAAAGLI
                     AGHYDVVVAGGVESMSRVPMGFPAQGRNPLGEQVLARYGGVRPNQGIGAEMIVDRWGFS
                     RTQVDEFSLASHEKAAAAQDAGAFDDQLLPIAGVTADEGVRRGGSLEKLAGLKPAFRED
                     GVITAGNSSQISDGAAALLMTTSEKAAQLGLRPIARVHTAVLAGDDPVIMLTAPIPATR
                     KALQRSGLSISDIGVFEVNEAFAPVPMAWLAETGADAKSLNPHGGAIALGHPLGASGAR
                     IMTTLVHHMRAAGIRYGLQTMCEGGGQANATILELVA"
     gene            complement(10001..11575)
                     /locus_tag="IE290_RS12905"
                     /old_locus_tag="GCM10017786_26300"
     CDS             complement(10001..11575)
                     /NRPS_PKS="Domain: AMP-binding (5-411). E-value: 4.7e-80.
                     Score: 261.1. Matches aSDomain:
                     nrpspksdomains_IE290_RS12905_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416715.1"
                     /locus_tag="IE290_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26300"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_191244772.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-81, bitscore:
                     270.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYPGTHADADPEKPAVIMAGSGERLTYGELDERSTRLADALTRAG
                     LGRGDTVALLSDNSVRAYEVYWAALRSGRYLAAVNSHLSPAEVAYIVTDSGAKALVVSA
                     ALGPLAAEVAELLPDVLVKLVYGGAADGYADFDAFLATGSPERPADQPAGADMLYSSGT
                     TGRPKGIKVDLPDRQVDEPGDVLTPVLQHMYGFGPDTVYLSPAPVYHAAPLRFGATAQR
                     LGGTVVMMERFDAEAALRAIETHRVTHSQWVPTMFVRMLKLPPAVRGRYDLSSHRVAVH
                     AAAPCPVEVKRAMIDWWGPVLYEYYASTEGAGMTFIDSEQWLARPGSVGRAVVGVAHIC
                     DDAGKLLPAGDIGTVYFERDEVPFTYHGDPDKTREAQHPEHETWTTTGDVGYLDEDGFL
                     YLTDRKAFMIISGGVNIYPQEVEDALALHPAVFDVGVIGVPDEEMGEAVKAFVQPAPGV
                     TPGPELEAELLAYVRERIAHYKAPRSVDFVDELPRTPTGKLVKRRLKEKYVAAATANQK
                     EEPCETR"
     aSDomain        complement(10343..11560)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12905_AMP-binding.1"
                     /evalue="4.70E-80"
                     /label="IE290_RS12905_AMP-binding.1"
                     /locus_tag="IE290_RS12905"
                     /protein_end="411"
                     /protein_start="5"
                     /score="261.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HADADPEKPAVIMAGSGERLTYGELDERSTRLADALTRAGLGRGD
                     TVALLSDNSVRAYEVYWAALRSGRYLAAVNSHLSPAEVAYIVTDSGAKALVVSAALGPL
                     AAEVAELLPDVLVKLVYGGAADGYADFDAFLATGSPERPADQPAGADMLYSSGTTGRPK
                     GIKVDLPDRQVDEPGDVLTPVLQHMYGFGPDTVYLSPAPVYHAAPLRFGATAQRLGGTV
                     VMMERFDAEAALRAIETHRVTHSQWVPTMFVRMLKLPPAVRGRYDLSSHRVAVHAAAPC
                     PVEVKRAMIDWWGPVLYEYYASTEGAGMTFIDSEQWLARPGSVGRAVVGVAHICDDAGK
                     LLPAGDIGTVYFERDEVPFTYHGDPDKTREAQHPEHETWTTTGDVGYLDEDGFLYLTDR
                     KAFMIIS"
     CDS_motif       complement(11060..11107)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS12905_0001"
                     /evalue="7.30E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="IE290_RS12905"
                     /protein_end="172"
                     /protein_start="156"
                     /score="15.6"
                     /tool="antismash"
                     /translation="MLYSSGTTGRPKGIKV"
     misc_feature    complement(11661..11681)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.22"
                     /tool="antismash"
     gene            11669..12298
                     /locus_tag="IE290_RS12910"
                     /old_locus_tag="GCM10017786_26310"
     CDS             11669..12298
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981330.1"
                     /locus_tag="IE290_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26310"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_229874448.1"
                     /transl_table=11
                     /translation="MVTETRNRQDRAAGTRTLILDAAVACLVELGYAGASTLAIQAKAG
                     VSRGRLLHHFPSRDELLVAASQHLTATRLAQTEVRVAEQLADEPEGPRRVERCIELLWT
                     TFHEPPFWAAVELWTAARTNAALAAALRPEERALRDAIREVGDRIWGPAVCAHPNYPEL
                     RELLFTSMRGAALPYTFERRRDPSNDPHVPLWKSLAHRLLFADGQC"
     gene            12361..13953
                     /locus_tag="IE290_RS12915"
                     /old_locus_tag="GCM10017786_26320"
     CDS             12361..13953
                     /EC_number="6.2.1.3"
                     /NRPS_PKS="Domain: AMP-binding (21-425). E-value: 1.6e-110.
                     Score: 361.5. Matches aSDomain:
                     nrpspksdomains_IE290_RS12915_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154623.1"
                     /locus_tag="IE290_RS12915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26320"
                     /product="long-chain-fatty-acid--CoA ligase"
                     /protein_id="WP_229874449.1"
                     /sec_met_domain="AMP-binding (E-value: 3.7e-116, bitscore:
                     384.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGVVEVPRLLGRGMTMGDQLARHARTQGGRPAFSFEGATLTYSQ
                     FDTRVSRLANALRERGVGYGDRVVVLGLNTLEVLETYFASTRLGAICVPVNFRLVADEI
                     AYVLADSGARASVVHAPLAPALAKAREQVDDPGPCLVFGGAFEGMADYEEALAAASPEF
                     DEITVDEQDPAFIMYTSGTTGRPKGAVLTHHNLLMHAFSNMASLGTGPEDKVWLAAAPL
                     FHIAGLSGMLPNLLLGGRTVLLPSGQFDPVAVVDLMERERVSSVFLVPAQWQAIVNVPG
                     IRERDLSALSKISWGAAPASTTLLRTMIEVFPQAEVTTAFGQTECSPVTTLLRGEDSIR
                     KIGSVGKPMLNVEVRVVDDDMNDVPRGEVGEIVYRSPMVMKEYWNKPAETAEAFRGGWF
                     HSGDLVRQDEDGYYFVVDRKKDMIISGGENIYCAEVENVLAAHPKIGEVALIGMPDDKW
                     GETPLAVISPRTPGDAPTAAELEEWCLDRLARYKRPRRIAVVPALPRNPSGKVLKTQLR
                     ADREAGKLPIESA"
     aSDomain        12424..13635
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12915_AMP-binding.1"
                     /evalue="1.60E-110"
                     /label="IE290_RS12915_AMP-binding.1"
                     /locus_tag="IE290_RS12915"
                     /protein_end="425"
                     /protein_start="21"
                     /score="361.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARHARTQGGRPAFSFEGATLTYSQFDTRVSRLANALRERGVGYGD
                     RVVVLGLNTLEVLETYFASTRLGAICVPVNFRLVADEIAYVLADSGARASVVHAPLAPA
                     LAKAREQVDDPGPCLVFGGAFEGMADYEEALAAASPEFDEITVDEQDPAFIMYTSGTTG
                     RPKGAVLTHHNLLMHAFSNMASLGTGPEDKVWLAAAPLFHIAGLSGMLPNLLLGGRTVL
                     LPSGQFDPVAVVDLMERERVSSVFLVPAQWQAIVNVPGIRERDLSALSKISWGAAPAST
                     TLLRTMIEVFPQAEVTTAFGQTECSPVTTLLRGEDSIRKIGSVGKPMLNVEVRVVDDDM
                     NDVPRGEVGEIVYRSPMVMKEYWNKPAETAEAFRGGWFHSGDLVRQDEDGYYFVVDRKK
                     DMIIS"
     CDS_motif       12880..12939
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS12915_0001"
                     /evalue="1.00E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="IE290_RS12915"
                     /protein_end="193"
                     /protein_start="173"
                     /score="27.3"
                     /tool="antismash"
                     /translation="AFIMYTSGTTGRPKGAVLTH"
     CDS_motif       13453..13542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS12915_0002"
                     /evalue="1.60E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="IE290_RS12915"
                     /protein_end="394"
                     /protein_start="364"
                     /score="23.7"
                     /tool="antismash"
                     /translation="PRGEVGEIVYRSPMVMKEYWNKPAETAEAF"
     gene            complement(<13965..>14090)
                     /locus_tag="IE290_RS12920"
                     /pseudo=""
     CDS             complement(<13965..14090)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611567.1"
                     /locus_tag="IE290_RS12920"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MWSWVVVGRPRSGAPWRGLPERYGPWKTAHERLWTADGTWQK"
     gene            complement(14122..15342)
                     /locus_tag="IE290_RS12925"
                     /old_locus_tag="GCM10017786_26330"
     CDS             complement(14122..15342)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019845.5"
                     /locus_tag="IE290_RS12925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26330"
                     /product="alcohol dehydrogenase catalytic domain-containing
                     protein"
                     /protein_id="WP_229874450.1"
                     /sec_met_domain="ADH_N (E-value: 3.7e-20, bitscore: 68.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATDRPIPPRNALAHYAAMLTPNALNAAALALWRDAPARWTRIVG
                     AVRGRRRASMRGLVVLPGGGPRWRSVPAPSLPGPAGALVRPLAVATCDLDRAMMLGRTP
                     FPLPLHLGHECVAEVLEVGDFVRSVRPGQRVVVPFQISCGACPPCRHGFTGSCTAVPPA
                     SMYGFGLAGGLWGGALADRLAVPFADAMLVPLPEGIDPAAAAGVADSVSDAYRQVAPHL
                     PALLAREPDAEVLIVGRTTRRDPLTSSTVLYAGLIARALGARRVSVADSRPGVRELAAG
                     LGLGALDARRPREWPTAPLTVDATGTPAGLRQVLRHTAPDGVCTCVWSLHRRAAVPLAA
                     AYVRNVTVHIGRSHVRTLIPEVLALMADGRLRPEVVTSNTAPFSAAPAALREHCHDDAI
                     KTVLVAD"
     misc_feature    15337..15347
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            15407..16048
                     /locus_tag="IE290_RS12930"
                     /old_locus_tag="GCM10017786_26340"
     CDS             15407..16048
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="IE290_RS12930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26340"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_191244774.1"
                     /transl_table=11
                     /translation="MAVVQPPSRPYRGTPAQDRVTARRDRLIKAGIDVFGTIGYRAATV
                     QRVCAGAGLTKRYFYESFADSEALLLACYERAADQIHAAMVGAVTGAPATLADRLHAAL
                     AGYYGAIADDQRLARLTLLEILGVSPAVDAAYQAQTERFARSVELLAVEAFQASGLTPV
                     RRHLVAQGIIGAITTTATQWLLTGRRTPLGDVVAASETLVLAVLDHLRGA"
     gene            complement(16087..17025)
                     /locus_tag="IE290_RS12935"
                     /old_locus_tag="GCM10017786_26350"
     CDS             complement(16087..17025)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416712.1"
                     /locus_tag="IE290_RS12935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26350"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_191244775.1"
                     /sec_met_domain="HMGL-like (E-value: 5.7e-47, bitscore:
                     156.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASVRELGLPQREASRNELPDRITIWEVGARDGLQNEQTVVSLDT
                     KLEFLDRLAAAGLTTLEATSFVHPKWVPQLADADDLLAKLDRRPGTNYPVLVPNERGLD
                     RALALGVESIAIFGSATETFARKNLNRSFDEQFAMFEPVVRRARHEGLEVRAYLSMCFG
                     DPWEGAVPVEQVATAGRRLLDMGCFQLSLGDTIGVATPGHVEAVLAGFGDVSQLAVHFH
                     DTYGQALSNTLAALRAGVTTVDSSAGGLGGCPYAKAATGNLATEDLVWMLDGLGVEHGV
                     DLDALVRTSAWMAQQLGRPSPSRVVKALTGG"
     gene            complement(17433..18548)
                     /locus_tag="IE290_RS12940"
                     /old_locus_tag="GCM10017786_26360"
     CDS             complement(17433..18548)
                     /EC_number="1.1.99.36"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (20-288). E-value: 1.8e-11.
                     Score: 35.7. Matches aSDomain:
                     nrpspksdomains_IE290_RS12940_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019812534.1"
                     /locus_tag="IE290_RS12940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26360"
                     /product="NDMA-dependent alcohol dehydrogenase"
                     /protein_id="WP_191244776.1"
                     /sec_met_domain="ADH_N (E-value: 3.6e-30, bitscore: 100.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.5e-23, bitscore:
                     78.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVKAAVLTDFKTPFEITELDLDGPKEGEVLIRYVAAGLCHSDLH
                     LSDGDLPPRFPIVGGHEGAGIIEEVGPGVTKVKPGDHVVCSFIPNCGTCRYCATGHQSL
                     CDMGATILEGSFPDGSFRFHSGGVDYGQMCMLGTFAEYSTISQHSVVKVDESVPLETAV
                     LVGCGVPTGWGTAVYAGDVRPGETVVIYGIGGIGINSVQGAAHAGAKNVVVVDPLAFKR
                     DTALKLGATHAFATAAEAHEVVTELTRGQGADKALVTVGVVDEEVMSAAFDVVGKGGVV
                     VVTGLADPAKATIHVSGAVLTLWEKTIKGSLFGSGNPQRDILKMLDLYQAGSLKLDELV
                     TNRYRLEDVNQGYEDLVAGKNIRGVVVHGQG"
     aSDomain        complement(17685..18488)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS12940_PKS_ER.1"
                     /evalue="1.80E-11"
                     /label="IE290_RS12940_PKS_ER.1"
                     /locus_tag="IE290_RS12940"
                     /protein_end="288"
                     /protein_start="20"
                     /score="35.7"
                     /tool="antismash"
                     /translation="DLDGPKEGEVLIRYVAAGLCHSDLHLSDGDLPPRFPIVGGHEGAG
                     IIEEVGPGVTKVKPGDHVVCSFIPNCGTCRYCATGHQSLCDMGATILEGSFPDGSFRFH
                     SGGVDYGQMCMLGTFAEYSTISQHSVVKVDESVPLETAVLVGCGVPTGWGTAVYAGDVR
                     PGETVVIYGIGGIGINSVQGAAHAGAKNVVVVDPLAFKRDTALKLGATHAFATAAEAHE
                     VVTELTRGQGADKALVTVGVVDEEVMSAAFDVVGKGGVVVVTGLAD"
     gene            complement(18560..20059)
                     /locus_tag="IE290_RS12945"
                     /old_locus_tag="GCM10017786_26370"
     CDS             complement(18560..20059)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981326.1"
                     /locus_tag="IE290_RS12945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26370"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_191244777.1"
                     /sec_met_domain="Aldedh (E-value: 1.1e-178, bitscore:
                     590.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVAEQAVHPAVREFVSGTKRLLIGGQWVNAASGRTFPTFDPAT
                     GEKITEVAHGAAEDVDRAVAAARRAFEDGPWSRTTPSERQRLIWRVGDLLLERAEQFAQ
                     LEALDNGKSVAVAQGVDVAWSADIFHYYAGWATKIEGRTITPSVPWIPGSQWHAYTLRE
                     PVGVCAQIIPWNFPLVMAAFKLAPALAAGNTVILKPAEQTPLTALLLGELFCEAGFPDG
                     VVNILTGFGDAGAALAAHDDVDKVAFTGSTEVGKKIVDAAKGNLKKVSLELGGKSPNIV
                     FADADLEAAIPGSANAWLFNHGQCCVAGTRLFVEESIFDEFTQGVAEFASQVKIGPGLD
                     PTTQLGPLVSQEQLDRVTSYLRQGLADGARALTGGGRHGDSGYYVEPTVLVDVREDMSV
                     VREEIFGPVVAAIPFSAEDGLAAAANDTEYGLAAGIWTRDISKAHRVAKQIKAGSVWVN
                     CYNGFDTAIPFGGYKQSGWGRELGAEAIDLYTQTKAVNVAL"
     misc_feature    complement(20102..20119)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     gene            20174..20518
                     /locus_tag="IE290_RS12950"
                     /old_locus_tag="GCM10017786_26380"
     CDS             20174..20518
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416709.1"
                     /locus_tag="IE290_RS12950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26380"
                     /product="DoxX family protein"
                     /protein_id="WP_191244778.1"
                     /transl_table=11
                     /translation="MNITLWIIAGLLAAVFLASGSQKLAQPAEKLAATGLTVGAGKTVG
                     ALEVLAAAGLILPAALDVAPVLTPLAAAGLVLLMAAAAVFHVRRHEWKTLPVPLVLLAL
                     AVVVAVGRFA"
     gene            complement(20521..22128)
                     /locus_tag="IE290_RS12955"
                     /old_locus_tag="GCM10017786_26390"
     CDS             complement(20521..22128)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54
                     dependent trancsriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981323.1"
                     /locus_tag="IE290_RS12955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26390"
                     /product="sigma-54-dependent Fis family transcriptional
                     regulator"
                     /protein_id="WP_191244779.1"
                     /transl_table=11
                     /translation="MESAALRPEIASSWRRAELSGLRPDAAVDRLTVEDIDRRSRLVLA
                     AEPVLDQATRELADTAFGLVLADRDAWIVDRRFGERRLEATFDRIGVVPGTRFTEENTG
                     TNSIATVFELRQGLAVHGHEHFIDSFKPFACYGHPITHPVTRRLEGVLDITCLADHANP
                     LLGPFLRRAVADIEQRLLEGSRAAEQRMLAAYQAAALNRLRPVLVLGDDVVLANAAATD
                     LLDAADHAVLRGLAMDAPFGVRQARSVRLSSGRVADVSFERITGASGVLFELEPPAVQA
                     IPRRVTPRPVQRDFATYREQRTHVLISGEPGTGRSTVARELAGESALAVLDAVDAQHWA
                     PTLDQLVASHTGLLVVENIALLPPDAAARLAAIMDRGDCWVALTGPSPPELTGPAADLA
                     SRCIARRELPPLRSRRDELPALVAAMLAEIGSTLRFVPRTLEVLAAQPWPGNLRELKAL
                     LRHIAAGRACGDVLPRDLPEAYQGSPKARHLTPIEQLEHDAIAAALRDCGGNKAHAAKL
                     LGISRSTLHRRVRSLGLS"
     gene            complement(22172..22789)
                     /locus_tag="IE290_RS12960"
                     /old_locus_tag="GCM10017786_26400"
     CDS             complement(22172..22789)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637608.1"
                     /locus_tag="IE290_RS12960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26400"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_229874451.1"
                     /transl_table=11
                     /translation="MTERKDLLRPDRPKERADAARNRARVLAAAEELFSRQRSVTMEDI
                     ARAAGVGRGTLYRRYPDVPSIALALLDEHERRVQEQLLRGEPPLGPGAPPHERLAAFYG
                     AMVGLLERHGHLALGAEIGRARFTTGAYGFWQAHVRALVTEAGHDPDALTDLLLAPIAP
                     DVYDYQRHQLGLSPEKVTAALTRIAHGVLGTPGRGQVLDPPR"
     misc_feature    complement(22845..22859)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.69"
                     /tool="antismash"
     gene            22880..23533
                     /locus_tag="IE290_RS12965"
                     /old_locus_tag="GCM10017786_26410"
     CDS             22880..23533
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033781.1"
                     /locus_tag="IE290_RS12965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26410"
                     /product="FMN-dependent NADH-azoreductase"
                     /protein_id="WP_191244781.1"
                     /transl_table=11
                     /translation="MTTLLHVDSSARRDSFSRRLGQAFAGAWRDAAPDGRYIHRDLAAA
                     PVRPIGQAWTEICDNLLRDGITEIGRYPEAVRTPAQEAAWAVVAPLLDEVVTADVVLIG
                     APMYNFSIPAALKAWLDQITFPRMSLRGKRFVVVGARGGSYAPGTPRAPFDHHERYLRD
                     FFSGHFGVDDPVFVNAELVNSTVDPHLRHLRDRHEESAANALRAAADLGKELAL"
     gene            23530..23856
                     /locus_tag="IE290_RS12970"
                     /old_locus_tag="GCM10017786_26420"
     CDS             23530..23856
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560960.1"
                     /locus_tag="IE290_RS12970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26420"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_191244782.1"
                     /transl_table=11
                     /translation="MSWVLLVLAGLVEVAWSQSIKPTDNFTRPWPTVLCFLLAATAVYL
                     LSRAMNTLPVGTAYAVFTGIGAVGAVVLGVVVHRDPVTLGRGLALALILGGVVLAYATD
                     TGGA"
     gene            complement(23829..24329)
                     /locus_tag="IE290_RS12975"
                     /old_locus_tag="GCM10017786_26430"
     CDS             complement(23829..24329)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102351.1"
                     /locus_tag="IE290_RS12975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_26430"
                     /product="DinB family protein"
                     /protein_id="WP_191244783.1"
                     /transl_table=11
                     /translation="MPDNRITDGAERAIIEDMLDRNRAALIVTVRGLSEADARRRLVAS
                     LTTPLSLIKHAAAAERIWFQRFWAGLDASECDGYSERDEGTFAVADEESVADVIAEFER
                     ASRRSREIAARFDLGDTKHNPREGTVSMRWTLLSMIEEFARHAGHGDILREQIDHAPPV
                     SVA"
     misc_feature    complement(24490..24504)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.13"
                     /tool="antismash"
ORIGIN
        1 gcaccccgca ggaacggcgc gacgtcccgt tccgcggtta caagctggcg tacccgatgc
       61 tctccgcgga cggcaccgaa gccgggttca ccggggtgtc gctcggacgc acgcacgcct
      121 accgggtgat cgccgaggcg aagtgcgcgc agagcagccg ccaccagagc ccgtcccgcc
      181 tgtgcgactg cgggttctac tgcttccacg aactcgccga cgcccgcgcc ctggcgtgcg
      241 atccgcagta ccagcagagc gtgctgctgg aggtggacgc cgcggggcgg tacttcctgt
      301 acgagcgggg cgtgcggtac tcgaagcaga cggtgacggc cgtgcacgcc gggttgtgcg
      361 cgtgcgggtg gccggcgcag gtgttcgtgg cgaccggcac cggggtcgtg gggtggcgca
      421 agctgctgcc ggtgtgctcg acgtgcgcgg gcaaccggcc gccgctgacg ctggagcact
      481 tcagccgcct ggccggggtg cccgtgcacc gcgacgaccg cgcggtggcg ttcaccaccg
      541 gcgcgacggc cgccgggccg gagctggtgc cgctgctgtc cgcggaggtc gctctgctgc
      601 acgcccggct ggatgaactg cagacgcagc tggacaagct gacgaagggc agctgaggcc
      661 gtccgcgggt ggctcgtccg ggtgaattct tgcccgtcag cggtccgccg gagccgcgtc
      721 cgcgtggttc agtcgcagcc ccggtcgcgg ccactccgcc gcccagagtt tgcccacccc
      781 tgacgacgtg atgtacgccg tccgcaggtc ggggccgccg aagcagatgt tcgtcacgaa
      841 gcggtccggc gacggcggcc gcacgacctc cagcagctcc cccgcggggc tgagcacgct
      901 gatcccgccg gtgatgatcg tcgccacgca gatgttgccc gccgaatcca ccgcgagtga
      961 gtcgagcagc tggtagccgc cgaaaccgtg cagcagcttc gcccccgccg ggcccaccgc
     1021 gccggccgga cgcgaaatcc ggcccggccc gtcgacgttc cagaaccaca cccgcccggt
     1081 caccgtctcc gccgcgtaca cccgcgaacc gtccggggac aggcccaccc cgttcagccc
     1141 ggtgaacccg taggcgatct cctcgatccc cgaaccgtcc gcccgcgcgt agtacaaacc
     1201 gccgcgatcg ctgtcccgcg gccggtcctt gcccaggtcc gtgaagtaga acccgccgtg
     1261 cgcgtcgaac accaggtcgt tcggcccgcg caacggccgc ccgtccaccg acgtgtacag
     1321 ctgcgtcacc acgccgtccc acgacacccg ctggatgcac ccgccgcggt agtccggcgg
     1381 ctgctcgccg ggcatcgtca ccccgccgcg ccggtgccag gtgaacccgc cgctgttgca
     1441 cacgtagatc gccccgcccg gcccgatcgc cgcgccgttc ggcccgccgc cgcagtccgc
     1501 gaccaccgtg acggacccgt ccggccacac ccgcgacaac gtgccgcgct cgacctccac
     1561 gaccagcacc gaaccgtcgt ccagcgcgac cggcccctcc gggaaccgca gcccgctcgc
     1621 gatctccctc ataccgactc caggtacttc gggttcgcca ccagcaaccg gtcggtcacg
     1681 tcggcccgca ccaccccgac cacgtccgcc accaccacgg cccgggaccg caccgcccgc
     1741 gccagctccg cgtgcgacga gaaccccagc gccgccagcc gttccccgtg ccgcgcctcc
     1801 tgggaggcac cgtaacgcaa ctcccgcgag accatcgcca gcacgttcgc cgccacccgc
     1861 gcctggaacg acaaccgccc ctcggtgccc ggcacgacct cggcgcgcag gaactccccc
     1921 accgcctcga ccagctcggc cgcgctcggc cggccgtgca ggtcgggcac cggatccgcc
     1981 gccgcatcga ccgggacagc gggcacgccg agcgcggtca gcaggtcgtg ctcctgctcg
     2041 cacacccgcc gcccgaccgc cgccagctcg accgaccgga tccgcccgct caggtgccgg
     2101 tccgcctgcc gcaggcacag cacggcccac cggaccgtcc cgaacacctc ccaccagtgc
     2161 accgcggccg gatcgggccg gaacccggcc acctcggcgt agccgtccag cagctcctcc
     2221 cggctcccga acccgcccac cggcagcggc gagccgaacc gccacgcctt gacgcacaac
     2281 cagcccaggt cctccagcgg gtcgccgcgg tgcgccagct cccagtccag gacggcggcg
     2341 agcccgtccg ggccgacgat caggttgccg ttgcggaagt ccccgtgcac gaccgtgtca
     2401 cccgccggct ccggccggtg cgcccgcagc caccgcaacc cgatctccag cgacggcaac
     2461 ggctggccga gcgagtcgta cagctccacc agcgaatgca gcggatccac agaggacagt
     2521 ccaggcacgg cggtcatcgc gtggatgcgc gccgccaccc gccccaactc ggcggcgagt
     2581 ttcggccgca cgtccgcgaa ctccggttcc cgcagcaagc gacggggaat cgtctcgccg
     2641 tcgacgtgct cggtgatcag gtacggcgaa cccagcaggt ccgcgccgtg gtccaccagc
     2701 cgcggcacgg gcacaccggc ctcgtgcgcg gcccggatca acgcggcctc ccgcgccatc
     2761 tcctccggtc ggcactcccc cggcggatcc cgccgcagca ccagccgccc gcccggctcg
     2821 gcggtgaacg cccaggtctc ccggctcgcg ccaccgctga gccgccgcag cccggtgatc
     2881 ttcgcgccca gccgccgccc cagcgcctcc gccagcccgg tcatcgcttg tccggccccg
     2941 cgaacccgaa caggtacccg gcgatcttgc gcatctggat ctcctcggcg ccctcggtga
     3001 tccggtagcg gcggtggtgc cggtagatgt gctcgaacgg cgtgtgccgg gtgtagccga
     3061 gcccgccgtg cacctgcatc gcgcggtcgg cggcgtcgca caccagccgg ttggcgcggt
     3121 agttgcacat cgacaccttg tcgctgatca gcatgtggtc ggtgtggtcg agctcccacg
     3181 ccgtcttgcg caccagcgtg cgcaccagct cggcctcggt ctgcagctcg accagcggcc
     3241 actggatcgc ctgccgctcg gccagcgggc ggccgaacgt gcggcgcgcc cgggcgtagt
     3301 ccacgctgcg gtcgatgcag tactgcgccg cgccgacccc ggaggcggcc tgccggatgc
     3361 ggttctcgtg cacgaagtgc tgcgccagcg ccagcccgcc gccgacctcg ccgaacaccg
     3421 ccgccccggg cacgcggacg tcggtgagcg tgacctcggc gtggtcggtg ggcatgttga
     3481 acgtccacca gtggaagtcg accgagaacc cgggcgtgtc agtgggcacg atgaacgcgg
     3541 tgatgccgcg gggatcgccg ccctcgcccg aggtgcgcgc gaagatgacg tcgtgggtcg
     3601 ccgagtgcag gccggagttg aaccgcttgg cgccgttgag gatccagtcg tcgccgtcgc
     3661 gcaccgcggt ggtctccagc caggtcgcgt cgctgccgtg gtccggttcg gtcagtccga
     3721 acgcgacccg tttgcggccg gtgatcatgt cctcgacgaa ctcgctctgc tgctcgggcg
     3781 tgccggcggc gaggaacatg tgcacgaacg ggaagttgcc caccaccgac gactcgttct
     3841 ggaggtcgtt gtgcaggccc aggcccttcg cggcgaggtg ctcgcggatc acggccatgt
     3901 cgaggttgct gccgccgcca ccgccgaccg acttcggcag gccgtagcgc agccagcccg
     3961 cgcggtcggc gcgccggaac atctccttca gcagctcctc ccactcgcgc cgaggggtgc
     4021 cgccggcctc gaagtcggtg cgcgcgtact cgcggcggtg gtcgaagaag cgttcgttgt
     4081 cgtcctggcg ttgcaggggc cagatctcgt cttcgaggaa ctggtcgagg tcggtgagca
     4141 gctgccgcag cgccgcgggc aactcgaagt ccatcaggcg actccttgcg tggcgggaga
     4201 aacgtggggc actatccgcg gatgaccaac ccgttcgacc tcaccgggca cgcgtccgtc
     4261 gtcaccggcg gcaattccgg gatcggcctc gcgatggccg gcgcgctcgc cgccgccggc
     4321 gcggacgtcg ccatctgggg caccaacacc gaacgcaacg acgcggccgt cgccgagctg
     4381 tcccggcacg gcaccaaggt cctcgccgtc cgctgcgatg tgggcgacga ggacgaagtc
     4441 gagtccgcga tggcccgcag cgtggaagcg ttggggcgcc tggattcctg cttcgtcaac
     4501 gccggggtcg gcggcgcggg cagccgcttc accgagacgt cgctggagga gttccgccgc
     4561 gtcacccggg tggacctgga cggcgcgttc ctgaccctgc gcgcggcggc gcgggtgatg
     4621 ctggcgcagg gcaccggcgg cagcctggtc ggcacgtcga gcgtggcggc cgtgcagggt
     4681 cagccgcgcg ggcaggcgta cgcggcgagc aaggccgggc tgaccgcgat gatcaagtcg
     4741 atcgcggtcg agctggcccg gcacggcatc cgcgccaacg cggtcctgcc cggctgggtg
     4801 cacacgccgc tggcggcccc ggcgctggac tccgaggggt tccagcgccg ggtgctgccg
     4861 cggatgccgg tcggccgctg gggcaggccg gacgacttcg gcgcgctcgc cgtgtacctg
     4921 gcgagcccgg ccagcgcctt ccacaccgcc gacacgatca ccgtggacgg cggctacctc
     4981 agcttctgac cgggccaccg gttcacgggg tcccggggaa gggcgggacc ccgtcggggt
     5041 agtcggcgct gacccggccc gggaagttcg gtgatcgctt ctccaggaag gccatcacgc
     5101 cctccatcgc gtccttgccc gcaccgagct gcaggagcgc gcgggagtcc gcgcggtggg
     5161 cgtcccacgg cgtcggcgaa cccagcatgc cccacagcag ctgccgggac accgcgaccg
     5221 acaccgccga cgtgttgtcg gcgacctccc gggcgatcga caacgcggtc gggatcagct
     5281 cgtccggcgc gaccacgcgc gacaccagtc ctccggcgcg agcctcggcg gcgtcgaaca
     5341 cccggccggt cgcgacccac tccatggcct gcgagatgcc gacgacccgc ggcaggaacc
     5401 acgacgacgc ggcctccagc aggatcccgc gccgcgcgaa cacgaacccg aacttggcgt
     5461 tctcgctggc gatccggatg tccatcggca gcgacatcgt cacgccgatc cccaccgcgg
     5521 gcccgttgaa cgcgccgatg accaccttct tgcacgccgc gatccgcagc gccaccgcgc
     5581 caccggcgtc gcgtggcaca ccgtcgatct cgccgaaccc ctcgacctcg ccgatcacgt
     5641 ccttgttgaa cgtgcccgcg ccccgctcca ggtccgcgcc cgcgcagaac ccgcgccccg
     5701 cgccggtcac caccaccacg cgcaccgagt cgtccgcgtc ggcctcgtcg aacgccgcga
     5761 ccagctcgtg cgccatctcc agcgtgaacg cgttgagccg cgccggccgg ttcagcgtga
     5821 tcgtggcgat cccgtcggag acctcgtaga tgatctcgtc gtaactcacc gcaccgccca
     5881 tcgtcccgtg tatttcgctt cggtcttgtc gaggaacgcc tcgaacgcgg ccggcgcgtc
     5941 ctcggtcgcg aagttgatcg tctgtgcccg cgcctcgccc tccagggctt cgcgcagcgt
     6001 ccggctggcg ccttcttcga gcagcctctt gctcagcgcc agggcgatcg gcggcgcctc
     6061 ggccagttcc gcggccagcg agtccacaaa ggagtccagc tcgtccgccg gtgtggtcca
     6121 ggtgaccagg ccgaggtcgt gcgcctcggc cgcgccgatc atttcggccc gcaacgcgag
     6181 ccgtttcgcc tgctgcagcc cgacgagccg gggcagcagc cacgagccgc cgaagtcgag
     6241 cgacagcccg cggcgggcga agatctggct gaaccgcgcc cgctcggtgg ccaccacgag
     6301 gtcgcagccg agcgcgaggt tccagcccgc cccgaccgcc acgccgtcga ccttcgcgat
     6361 cgtcggtttc gagatctcgt tcagggcgag cgcgacgtcg ttcacccggt gcatccgcgt
     6421 cagcgggtgg tcctcgacgt cggtggagag gtcggcgccc ccgcagaagt cgccgccggc
     6481 accggtgacc accacgaccc gcacgtcgtc gtcccgctcg gcgtcgtgga aggcctggta
     6541 cagcccgtcc cacatgggca ggtcgatcgc gttcttgcgg tgcggccggt tcagggtcac
     6601 ggtcagcacc gcgcccgccc ggtcgagcag caccggctgg tccgtcacga agcaccgtcc
     6661 agtcgcccgg cgagccgggc cagttgctcg tcgtggccgc cgaacagcag ctcgctgctc
     6721 ttggcgcgct tgtagtacag gtgcgcgtcg tgctcccacg tgtagccgat gccgccgtgc
     6781 aactgcagac cggacgccgc cgccgcgaag taggcgggcc cggtgaacac ctgcgtggtg
     6841 gccgcggcca gcggcagcgc gtccgggtcg tggtcggcgg cccacgcggc gtgccgcagc
     6901 agggattccg cgcgctcgct ggtgctgtag aggtccgcgc aggcgtgttt gaccgcctgg
     6961 taggagccga tggcgcggcc gaactgcacc cgcaccttcg cgtactccac ggtggtctcc
     7021 agcactttcg cgatcccgcc gacctgctcc gcggccagcg ccaccgatgc gaggtcccgc
     7081 accttctcca gcaccgcggc cggatcggcg gtgtccagcc gccgcgccgg ggtgcccgcg
     7141 aagtcaagcc tcgcctgccc gcgcgtgggg tccaaagtgg tcaacgcggt gcgccgcgcg
     7201 tcctcggcca cgaaccaccc ggactccgtg cacaccacga agacgtcggc gacgtcaccg
     7261 gagatcacaa agggcacgtg cccgtcgagc acccagccgc cgtcccgctc ggtcgcgctc
     7321 accggcgccg ggccccactc cggcgaaacc gccagcgcgc cgatcttctc ccccgccgcc
     7381 agcgcgggca gcacctcggt gtcccccagc gccgccagcg cgtcgaccgc cagcaccgcg
     7441 gaggcgaaga acggcaccgg cgccagcgca cggcccagtt cctcgagcac gatgcaccgt
     7501 tcgacgtgac ccgcgcccgc gccgccctgc tcctcgggca cgaccagacc ggtcaggccg
     7561 agttcggcca ggtgccgcca cagcgcggcg tcgtaggtgt cgtcaccgtc caccacggac
     7621 cggacgttgt tgtggtcggc gagcagtttg cgcaccgtcg accgcagttg ctgctgttcg
     7681 gtgtcgagca ccagctgcac gatccctctc ctctcaggcg ggccgctgcg tgcccacccg
     7741 cagctcgcgg aagggcacgt cgcggtcgac gacgggttcg cggggcaggc cgaggatccg
     7801 gtcgccgatg atggtgcgct ggatctggtc ggtgccaccg gcgatgctcg acgacggcgt
     7861 ctggttgatc gccagcgcca gctcgtcccc ggccgcgtcg cccggttccc acgccgtggc
     7921 ccgcggcccg gcgatcagcc cggcgaccgc gacggcctgc tgctgcagct gcgcaccggc
     7981 gagcttcgcc accgacccgc gcgcgcccgg cggcgacccg gcttcggcct cctggcggag
     8041 ccgcgtgttg aacagagcca gcgcccgctc cgccgcgtac agcttcgcca gctcggcacg
     8101 cacgaccggg tcggagtcgc gcccgtaccg gcgcgcggtc tcggcgaggt tcgcgtgggc
     8161 cagcgggtcg tgccgcttgc gcacgaaccc gccgatcgac acgcgctcgt ggccgagcat
     8221 ggtgaccgcg gcgagccagc cctgcccgac ctgcccgagc acggcgtccg cgggcaggcg
     8281 caggttctcg aagtacacct cgttgaacgg cgcccgcccg gtcatgtcct tcagcggccg
     8341 cacggtcacc gccgggtcgt gcatgtcgat gaggaacatc gtcaggccct ggtgcttggg
     8401 cacgtccggg tccgtgcggg cgagcagcgc gccgaaatcg gccaggtgcg cgacggtcgt
     8461 ccacaccttc tgcccgttga ccacccatcc gtcgccgtcc cggacggcgc gcgtctgcag
     8521 gctcgccacg tccgatcccg cgcccggctc ggagaacagc tggcaccaga tctcctcgcc
     8581 acgcagcagc ggcgggatgt agcgggcctt ctgctccggt gtgcccaggt cgaggatcgt
     8641 cggcccgcac atgcccatcc cgatccggaa caccgagttg ggcaggtcgt agttggccga
     8701 ctcctggtcg aagatctgct gctcggccgc ggtgaggccc tggccgccga actccttcgg
     8761 ccaggtgatg ccggccagcc cggcgtcgta caacgcggcc tggaaccgct tggcggtctc
     8821 cagctcctcg tcacccggga cgtgctcggc gagccacgcc cggaccttct cgcggaactc
     8881 gctcatgcga cgagctccag gatggtcgcg ttggcctggc cgccgccctc gcacatggtc
     8941 tgcaggccgt agcggatccc ggcggcgcgc atgtggtgca cgagcgtggt catgatccgg
     9001 gcgccgctcg cgccgagcgg gtggccgagc gcgatcgcac cgccgtgcgg gttgagggac
     9061 ttggcgtcgg cgccggtctc ggccagccac gccatcggca ccggcgcgaa cgcctcgttg
     9121 acctcgaaca cgccgatgtc ggaaatcgac aggccgctgc gctgcaacgc tttccgcgtg
     9181 gccgggatgg gcgcggtcag catgatcacc ggatcgtcgc ccgcgagcac cgcggtgtgc
     9241 acccgcgcga tcggccgcag gcccagctgg gcggccttct cgctggtcgt catcaacagg
     9301 gcggccgcgc cgtcgctgat ctgcgagctg ttgccggcgg tgatgacgcc gtcctcgcgg
     9361 aacgcgggct tgagcccggc cagcttctcc agcgacccgc cgcggcgcac gccctcgtcg
     9421 gcggtaaccc cggcgatggg cagcagctgg tcgtcgaacg cgcccgcgtc ctgtgcggcg
     9481 gccgccttct cgtgcgaggc cagggagaac tcgtcgacct gggttcggct gaaaccccac
     9541 cggtcgacga tcatctccgc gccgatgccc tggttgggcc gcacgccgcc gtagcgggcc
     9601 agcacctgct cgcccagcgg gttcctgccc tgggcgggaa agcccatcgg cacccggctc
     9661 atcgactcga ccccgccggc caccaccacg tcgtagtgcc cggcgatcag cccagcggcg
     9721 gcgaagtgca cgctctgctg cgacgagccg cactgccggt cgacggtcac gccggtcacg
     9781 ctctccggcc agcccgcggc gagcacggcg ttgcggccga tgtcgccggt ctgctcaccg
     9841 gcctggctca cgcaccccca cacgacgtcg tcgatctcgg ccgggtcgat cccggcccgc
     9901 tcggccaggc cgcgcagcac gtgcgccgac aggtccaccg ggtgcacgcc ggacaggccg
     9961 ccctcacgct tgcccacggg ggtgcgcacc gcttccacga tcaccgcgtc tcgcacggct
    10021 cctccttctg gttcgccgtg gccgcagcca cgtacttctc cttgagccgc cgcttgacca
    10081 gcttcccggt cggcgtgcgg ggcagttcgt cgacgaaatc cacgctgcgt ggcgccttgt
    10141 agtgggcgat ccgctcgcgg acgtaggcca gcagctcggc ctccagctcc gggccgggcg
    10201 tgacaccggg cgcgggctgg acgaacgcct tgaccgcctc gcccatctcc tcgtccggca
    10261 cgccgatcac cccgacgtcg aacaccgcgg ggtgcagcgc gagcgcgtcc tcgacctcct
    10321 gcgggtagat gttcaccccg ccggagatga tcatgaacgc cttgcggtcg gtcaggtaga
    10381 ggaatccgtc ctcgtcgagg tagccgacgt cgccggtggt cgtccaggtc tcgtgctcgg
    10441 ggtgctgcgc ctcgcgggtc ttgtccggat caccgtggta ggtgaacggg acctcgtcgc
    10501 gttcgaagta gacggtgccg atgtccccgg ccggcagcag cttgcccgcg tcgtcgcaga
    10561 tgtgcgcgac gccgaccacc gcgcggccca ccgagccggg tcgcgcgagc cactgctcgc
    10621 tgtcgatgaa cgtcatcccg gcgccctcgg tggacgcgta gtactcgtag aggaccggcc
    10681 cccaccagtc gatcatcgcg cgcttgacct cgaccgggca cggcgccgcg gcgtgcaccg
    10741 cgacgcggtg gctggacagg tcgtagcggc cgcgcaccgc tggcggcagc ttgagcatcc
    10801 ggacgaacat cgtcggcacc cactggctgt gcgtgacgcg gtgggtctcg atggctcgca
    10861 gggcggcctc ggcgtcgaag cgctccatca tcaccaccgt gccgccgaga cgctgcgcgg
    10921 tcgcgccgaa ccgcagcggc gcggcgtggt agaccggcgc cggggacagg tacaccgtgt
    10981 ccgggccgaa gccgtacatg tgctgcagca cgggggtgag cacgtcgccc ggctcgtcca
    11041 cctggcggtc gggcaggtcg accttgatgc ccttcggacg gccggtcgtc ccggacgagt
    11101 agagcatgtc cgcgcccgcc ggctggtccg ccgggcgctc gggcgagccg gtggcgagga
    11161 aggcgtcgaa gtcggcgtac ccgtcggccg cgccaccgta gacgagcttg accagcacat
    11221 ccggcagcag ctcggcgacc tcggcggcca gcgggcccag cgcggcggag accaccaggg
    11281 ccttggcgcc ggagtcggtg acgatgtagg cgacctcggc cggggacagg tggctgttca
    11341 ccgcggccag gtagcggccg gagcgcagag cggcccagta gacctcgtac gcgcgcacgg
    11401 agttgtcgct gagcagggcg acggtgtcgc cacggccgag gccggcgcgg gtcagggcgt
    11461 cggcgaggcg ggtggagcgc tcgtcgagct cgccgtaggt cagccgctcg cccgaccccg
    11521 ccatgatcac ggcgggcttc tcgggatcgg cgtcggcgtg ggtacccggg tacatgtggc
    11581 tcctcttcga accgtggact cccctgcgag agtgcaagga ttcggcgtaa cagtcaacac
    11641 cgactgttat cgggttatgg tgatcggcgt ggtgaccgaa acccggaacc ggcaggaccg
    11701 cgcggcgggc acgcgcacgt tgatcctgga cgccgccgtg gcgtgcctgg tcgagctggg
    11761 ctacgcgggc gcgtccacgt tggccatcca ggccaaggcc ggtgtgtcgc ggggccggct
    11821 gctgcaccac ttcccgtccc gggacgagct gctggtcgcg gcctcgcagc acctgacggc
    11881 gacgcggctc gcccagaccg aggtgcgggt cgccgagcag ctggcggacg agccggaggg
    11941 cccgcggcgg gtcgagcggt gcatcgagct gctgtggacg accttccacg agccgccgtt
    12001 ctgggccgcg gtcgagttgt ggaccgcggc gcggaccaac gcggcgctcg cggcagcgct
    12061 gcggccggag gagcgggcgc tgcgggacgc gatccgcgag gtcggcgacc ggatctgggg
    12121 accggcggtg tgcgcgcacc cgaactaccc cgagctgcgg gaactgctgt tcacgagcat
    12181 gcggggcgcg gcgctgccct acaccttcga acgccgccgg gacccgtcga acgacccgca
    12241 cgtcccgctg tggaagtcgc tggcgcaccg cctgctcttc gccgacggtc agtgttgact
    12301 gtttcgctcc gcgcacggta gaaacgcggt acctgaccca ccggatcgcc gaggttgccg
    12361 atgtccggag ttgtcgaagt accgcgcctg ctcgggcgcg ggatgacgat gggcgaccag
    12421 ctcgcccgcc acgcacgcac ccagggcggc cggcccgcct tctcgttcga gggcgccacc
    12481 ctcacctaca gccagttcga cacgcgcgtg agccggctgg cgaacgcgtt gcgcgagcgg
    12541 ggcgtcggct acggcgaccg cgtcgtcgtg ctcggcctga acacgctgga agtgctggaa
    12601 acctacttcg cgtcgacgcg ccttggcgcg atctgcgtgc cggtgaactt ccggctcgtg
    12661 gccgacgaga tcgcctacgt gctcgccgac agcggggccc gggccagcgt ggtgcacgcg
    12721 ccgctcgccc cggcgctggc caaggcacgc gagcaggtcg acgacccggg cccgtgcctg
    12781 gtgttcggcg gcgcgttcga gggcatggcg gactacgagg aggcgctggc cgcggcgtcg
    12841 ccggagttcg acgagatcac ggtggacgag caggacccgg cgttcatcat gtacacctcg
    12901 ggcaccaccg ggcggccgaa gggcgccgtg ctcacccacc acaacctgct gatgcacgcg
    12961 ttcagcaaca tggcgtcgct gggcaccggg ccggaggaca aggtgtggct ggccgccgcg
    13021 ccgctgttcc acatcgccgg gctgtccggg atgctgccga acctgctgct cggcgggcgg
    13081 acggtgctgc tgccgagcgg ccagttcgac ccggtggcgg tggtggatct gatggagcgc
    13141 gagcgggtgt cgtcggtgtt cctggtgccg gcgcagtggc aggcgatcgt gaacgtgccg
    13201 gggatccgcg agcgggatct gtcggcgctg tcgaagatct cgtggggcgc ggcgccggcg
    13261 tcgacgaccc tgctgcgcac gatgatcgag gtgttcccgc aggcggaggt gacgacggcg
    13321 ttcgggcaga ccgagtgcag cccggtgacc acgctgctgc gtggcgagga ctcgatccgc
    13381 aagatcgggt cggtcggcaa gccgatgctc aacgtcgagg tgcgcgtggt cgacgacgac
    13441 atgaacgacg tgccgcgggg cgaggtgggc gagatcgtct accgcagccc gatggtgatg
    13501 aaggagtact ggaacaagcc ggccgagacg gcggaggcgt tccgcggcgg ctggttccac
    13561 tccggtgacc tggtgcggca ggacgaggac ggctactact tcgtggtgga ccgcaagaag
    13621 gacatgatca tctccggtgg cgagaacatc tactgcgccg aggtggagaa cgtcctggcg
    13681 gcgcacccga agatcggtga ggtcgcgttg atcggcatgc cggacgacaa gtggggcgag
    13741 acgccgctgg cggtgatctc accccggaca cccggcgacg cacccacggc ggccgagctg
    13801 gaggagtggt gcctcgaccg gttggcccgg tacaagcggc cgcgccggat cgcggtggtg
    13861 ccggcgctgc cgcggaaccc gagcgggaag gtgctgaaga cccagctgcg cgcggaccgg
    13921 gaggcgggca agctgccgat cgagtcggct tagccggcgt gccccttctg ccaggtgcca
    13981 tccgcagtcc acaaccgttc atgcgcggtc ttccaaggac cgtaacgttc gggcaagcca
    14041 cgccatggcg ccccggaccg cggccggccc accacaaccc aagaccaacc cagccctacc
    14101 agctagatca atcacaagac actagtcggc gacgaggacg gtcttgatcg cgtcgtcgtg
    14161 gcagtgctcg cgcagcgccg cgggcgccgc gctgaacggg gcggtgttcg aggtcaccac
    14221 ttcgggccgg agccggccgt cggccatgag ggcgaggacc tccgggatca gggtgcgcac
    14281 gtgactgcgt ccgatgtgga ccgtcacgtt ccggacgtac gcggcggcca gcgggacggc
    14341 ggcccgccgg tgcaacgacc acacgcacgt gcacacgccg tccggagcgg tgtgccggag
    14401 aacctggcgc agcccggccg gcgtgccggt ggcgtcgacg gtcagcgggg cggtgggcca
    14461 ctcgcgcggc cgccgggcgt cgagcgcacc gagcccgagc ccggctgcca gctcgcgcac
    14521 gccgggccgg ctgtcggcga cgctgacccg gcgcgcgccg agtgcccgcg cgatgagtcc
    14581 ggcgtagagc actgtgctgg aggtcaacgg atcccgccgg gtggtccggc cgacgatgag
    14641 cacctcggcg tcgggttcgc gcgcgagcag cgcgggcagg tggggcgcga cctgccggta
    14701 cgcgtcgctg acgctgtcgg ccacgccggc cgccgcggcc gggtcgatgc cctccggcag
    14761 cgggacgagc atggcgtcgg cgaacggaac cgcgagccgg tcggccagcg cgccgcccca
    14821 cagcccgccg gcgagcccga agccgtacat cgacgccggc ggtaccgcgg tgcagctgcc
    14881 cgtgaaaccg tgccggcacg gtgggcacgc cccgcagctg atctggaacg gcaccaccac
    14941 gcgctgcccc ggccgcaccg accgcacgaa gtcgccgact tcgagcacct cggcgacgca
    15001 ctcatggccg aggtgcaatg gcagcgggaa cggcgtccgc cccagcatca tcgcccggtc
    15061 caggtcgcag gtggcgacgg ccagcggccg cacgagcgcg cccgccggcc cgggtagcga
    15121 cggcgcggga accgatcgcc agcgcggacc gccgccgggc aagaccacca gtccccgcat
    15181 cgaggcccgt cgccgcccgc gcaccgcgcc gacgatgcgt gtccaccggg ccggggcgtc
    15241 ccgccacagc gcgagtgcgg ccgcgttcag cgcgttcggg gtgagcatcg cggcgtagtg
    15301 cgcgagcgcg ttccgcggcg ggatcggccg gtccgtggcc atgtcactcc cccaggacag
    15361 aaaccatgtg gttcccagtc ttgaacggga accggcgggt gtcaagatgg cggttgtgca
    15421 gccaccctcc cgcccgtacc ggggcacccc ggcgcaggac cgcgtcaccg cgcggcgcga
    15481 ccggctcatc aaggccggga tcgacgtctt cggcaccatc ggctaccgcg ccgccaccgt
    15541 gcagcgtgtg tgcgccgggg cggggctgac caagcgctac ttctacgagt ccttcgccga
    15601 cagcgaagcg ctgctgctcg cctgctacga gcgggcggcc gaccagatcc acgccgcgat
    15661 ggtgggtgcc gtgaccgggg cgccggccac gctcgcggac cggctgcacg ccgcgctggc
    15721 cgggtactac ggcgcgatcg ccgacgacca gcgcctcgcc cgcctcacac tgctggagat
    15781 cctgggcgtg agcccggccg tggacgcggc gtaccaggcc cagaccgaac gcttcgcccg
    15841 ttcggtcgaa ctcctcgccg tcgaagcgtt ccaggccagt ggcttgacgc cggtccggcg
    15901 gcacctcgtc gcgcagggga tcatcggcgc gatcaccacc accgcgacgc agtggctgct
    15961 caccgggcgg cgcacaccct tgggtgacgt cgtcgcggcg tccgagacgc tggtgctcgc
    16021 cgtcctcgat cacctcaggg gcgcttgacg accccgcgct tggaccgcgg gagggcgcgc
    16081 gaagccctag ccgccggtga gggccttcac gacgcgcgac gggctggggc ggccgagctg
    16141 ctgcgccatc caggcgctgg tgcgcaccag cgcgtccagg tccacgccgt gctcgacgcc
    16201 caggccgtcg agcatccaga cgaggtcctc ggtggcgagg ttgccggtgg cggccttggc
    16261 gtaggggcag ccgccgaggc cgcccgcgga ggagtccact gtggtcactc cggcccggag
    16321 cgcggcgagc gtgttggaca gcgcctggcc gtaggtgtcg tggaagtgca cggcgagctg
    16381 ggagacgtcg ccgaagcctg cgaggaccgc ctcgacgtgc cccggggtgg cgacgccgat
    16441 cgtgtcgccg agggagagct ggaagcagcc catgtcgagg agccgtcgcc cggcggtcgc
    16501 gacctgctcg acgggcacgg cgccctccca cgggtcgccg aagcacatgg agaggtaggc
    16561 gcgcacctcc agtccttcgt ggcgggcccg ccgcacgacc ggctcgaaca tcgcgaactg
    16621 ctcgtcgaag gagcggttga ggttcttgcg cgcgaaggtc tcggtggcgc tgccgaagat
    16681 cgcgatcgat tccacgccca gcgccagggc ccggtccagg ccgcgctcgt tggggaccag
    16741 gacggggtag ttcgtgcccg ggcgccggtc gagcttggcg agcaggtcgt cggcgtcggc
    16801 cagctgcgga acccacttgg ggtggacgaa actggtcgcc tcgagggtcg tcaggcccgc
    16861 cgcggcgagc cggtcgagga actcgagctt ggtgtccagg ctgaccacgg tctgctcgtt
    16921 ctggagcccg tcacgcgccc cgacctccca gatcgtgatt cgatcgggca gctcgttccg
    16981 ggacgcctcc cgctggggca gccccagctc acgcacacta gccacaccca caggttaacg
    17041 ctgactaacg cggacgtcca gcggcgcgca ctgaacccag cgaccacctc gccaaggtga
    17101 cgggcgtgct gttccgtcat cccggagcct gcccgtccgg cgaggacatc tcttgatctt
    17161 taaaccggcg ccgccttcgg caggcgaaga gcccgcccta cgggcggagg cgccttacgg
    17221 cgccgaacgg tcaccttacg accacccccg cccccgattc ctgattgtgt ttcggtcgcc
    17281 gatcaggcgt gtcaaggcgg gaaagagtac cttgacacgc ctgatcggcg accaaaagca
    17341 ggctgtggat cgggggcggg ggaggtctgg ggcgtagtcg gtctccttgc gtcgccggct
    17401 gcctgcccgt tctctctccc ccgccacctg tcctaacctt ggccgtgcac caccacgccc
    17461 cggatgttct tgcccgccac caagtcttcg tacccctggt tcacatcctc caggcggtac
    17521 cggttggtca ccagctcgtc cagcttcagg ctgccggcct ggtacaggtc cagcatcttg
    17581 aggatgtccc gctgcgggtt gccgctgccg aacaggctgc ccttgatcgt cttctcccac
    17641 agggtcagca ccgcgccgga gacgtggatc gtcgccttcg cggggtccgc caagcccgtc
    17701 accacgacga ccccgccctt gccgacgacg tcgaacgcgg ccgacatgac ctcctcgtcc
    17761 accacgccga ccgtgaccag cgccttgtcg gcaccctgcc cccgggtcag ctcggtgacc
    17821 acctcgtgcg cctcggccgc ggtggcgaac gcgtgcgtgg cgcccagctt caacgcggtg
    17881 tcccgcttga acgccaacgg atcgaccacc acgacgttct tcgccccggc gtgggccgcg
    17941 ccctgcaccg agttgatgcc gatcccgccg atcccgtaga tcaccacggt ttcgcccggc
    18001 cgcacgtcac ccgcgtacac cgccgtgccc cacccggtcg gcacgccaca gccgacgagc
    18061 accgccgtct ccagcggcac gctttcgtcc actttgacca ccgagtgctg cgaaatcgtg
    18121 gagtactcgg cgaacgtgcc gagcatgcac atctgaccgt agtccacgcc accggagtgg
    18181 aaccggaaac tgccgtccgg gaagctgccc tccaggatcg tcgcgcccat gtcgcacagg
    18241 ctctggtgcc cggtggcgca gtagcggcag gtgccgcagt tcgggatgaa cgagcacacc
    18301 acgtggtccc cgggcttgac cttcgtcacc cccggcccga cctcctcgat gatcccagcg
    18361 ccctcgtgcc cgccgacgat cgggaaccgc ggtggcaggt caccgtcgga caggtgcagg
    18421 tccgagtggc acaacccggc ggcgacgtag cggatgagga cctcgccctc cttcgggccg
    18481 tccaggtcca gctcggtgat ctcgaacggg gtcttgaaat cagtcagtac agcagccttg
    18541 accttcatgg gaactctcct cagagcgcga cgttgacggc tttggtctgg gtgtagagat
    18601 cgatggcctc ggcgccgagc tcgcggcccc agccggactg cttgtacccg ccgaacggga
    18661 tcgcggtgtc gaagccgttg tagcagttga cccacaccga accggccttg atctgcttgg
    18721 ccacccggtg cgccttggag atgtcccgcg tccaaatgcc ggcggccagg ccgtactcgg
    18781 tgtcgttcgc cgccgcggcg agaccgtcct cggccgagaa cgggatcgcg gccaccaccg
    18841 ggccgaagat ctcctcgcgc accacgctca tgtcctcgcg cacgtccacc agcaccgtcg
    18901 gctcgacgta gtagccggag tcgccgtgac ggccgccgcc ggtcagggca cgggcgccgt
    18961 cggcgaggcc ctgccgcagg tagctggtga cgcggtcgag ctgctcctgc gacacgagcg
    19021 ggccgagctg cgtcgtcggg tccaggcccg ggccgatctt gacctggctg gcgaactcgg
    19081 cgacgccctg cgtgaactcg tcgaagatgg actcctcgac gaacaaccgc gtgccggcca
    19141 cacagcactg gccgtggttg aacagccagg cgttggccga gccggggatc gcggcctcca
    19201 ggtcggcgtc ggcgaacacg atgttggggc tcttgccgcc cagctccagc gacaccttct
    19261 tcaggttgcc cttggccgcg tccacgatct tcttgcccac ctcggtggag ccggtgaacg
    19321 cgaccttgtc gacgtcgtcg tgcgcggcca gcgcggcgcc cgcgtcaccg aacccggtga
    19381 ggatgttgac cacgccgtcc gggaacccgg cctcgcagaa cagctcgccc agcagcagcg
    19441 cggtgagcgg ggtctgctcg gccggcttga ggatgaccgt gttgccggcc gcgagcgcgg
    19501 gcgcgagctt gaacgcggcc atcaccagcg ggaagttcca cgggatgatc tgcgcgcaca
    19561 cgccgaccgg ttcccgcagc gtgtacgcgt gccactggct gcccgggatc cacggcaccg
    19621 aaggggtgat cgtgcggccc tcgatcttgg tggcccaccc cgcgtagtag tggaagatgt
    19681 cggccgacca ggcgacgtcg accccctgcg cgacggccac ggacttgccg ttgtcgagcg
    19741 cctccagctg cgcgaactgc tcggcgcgct ccagcagcag gtcacccacg cgccagatca
    19801 ggcgctgccg ctccgacggg gtggtgcgcg accacggccc gtcctcgaac gcgcgccgcg
    19861 ccgcggccac cgcgcggtcg acgtcctcgg cggcgccgtg cgccacctcg gtgatcttct
    19921 cccccgtggc ggggtcgaac gtggggaacg tccggcccga cgccgcgttc acccactgcc
    19981 cgccgatcag cagccgcttg gtcccggaca cgaactcccg caccgccgga tgcacggcct
    20041 gctccgctac cgcagtcaca ccaacctcct cgtcgtggac gtggcggtaa tggtgacctg
    20101 cgcaacagcg agctaactgt gtcaagttga cacagtggcc tcacaccgcg cggcgctgcg
    20161 tcgtcggaag ggcatgaaca tcacactgtg gatcatcgcc ggactgctgg ccgctgtctt
    20221 cctcgccagt gggtcgcaga aactcgccca gcccgcggag aagctggccg ccaccgggct
    20281 caccgtcggc gcgggcaaga cggtcggcgc cctggaggtc ctggccgcgg cgggcctcat
    20341 cctgcccgcc gcgctggacg tcgcgccggt gctgacaccg ctcgccgcgg ccgggctggt
    20401 gctgctgatg gccgccgcgg ccgtcttcca cgtgcgccgc cacgagtgga aaaccctgcc
    20461 cgtgccgctg gtcctgctgg cgctggccgt ggtcgtcgcc gtgggacggt tcgcgtgagc
    20521 tcagctcagc ccgaggctgc gcacccggcg gtgcagggtc gagcggctga tgccgagcag
    20581 cttcgcggcg tgggccttgt tcccgccgca gtcccgcagc gcggcggcga tcgcgtcgtg
    20641 ttcgagttgc tcgatcggcg tcaggtgacg tgctttcggg ctgccctggt aggcctccgg
    20701 gaggtcacgc ggcagcacgt caccacaggc ccggccggcc gcgatgtgcc gcagcagcgc
    20761 cttcagctca cgcaggttgc ccggccacgg ctgcgcggcc agcacctcca gcgtgcgcgg
    20821 cacgaaccgg agcgtggacc cgatctccgc cagcatcgcc gcgaccaggg ccggcagctc
    20881 gtcccggcgg gaccgcagcg gaggcagctc gcggcgggcg atgcagcggc tggcgaggtc
    20941 cgcggcgggg ccggtcagct cgggcggcga cgggccggtg agcgcgaccc agcagtcgcc
    21001 gcggtccatg atcgcggcga gccgggcggc ggcgtcgggc ggcagcagcg cgatgttctc
    21061 gaccaccagc agcccggtgt gggaggcgac gagctggtcg agggtgggcg cccagtgctg
    21121 ggcgtcgacg gcgtcgagca ccgccagtgc cgactcgccg gcgagctcgc gggccacggt
    21181 cgagcggccg gtgccgggtt cgccgctgat caacacgtgc gtgcgctgct cgcggtaggt
    21241 cgcgaagtcg cgctgcaccg ggcgcggggt gacgcggcgc ggaatcgcct gcaccgcggg
    21301 cggttccagc tcgaacagca cgccggaggc gccggtgatg cgctcgaacg acacgtccgc
    21361 gacccggccg gaggacagcc gcacgctgcg cgcctgccgt acgccgaacg gcgcgtccat
    21421 cgcgagcccg cgcagcacgg cgtggtcggc ggcgtcgagc aggtcggtgg ccgcggcgtt
    21481 ggcgagcacg acgtcgtcgc ccagcacgag gaccgggcgc aggcggttga gggcggcggc
    21541 ctggtaggcg gcgagcatgc gctgctcggc ggcgcgcgag ccctccagca ggcgctgctc
    21601 gatgtcggcg accgcgcggc gcaggaacgg gcccagcagc gggttcgcgt gatcggccag
    21661 gcaggtgatg tcgaggacgc cttcgagccg gcgggtcacc gggtgggtga tcgggtggcc
    21721 gtagcaggcg aagggcttga agctgtcgat gaagtgctcg tgcccgtgca cggccaggcc
    21781 ctggcgcagc tcgaacacgg tcgcgatcga gttggtgccg gtgttctcct cggtgaagcg
    21841 ggtgccgggc accacgccga tgcggtcgaa ggtggcttcc agccggcgct caccgaagcg
    21901 gcggtcgacg atccaggcgt cacgatcggc caggacgagg ccgaacgcgg tgtcggcgag
    21961 ctcgcgggtg gcctggtcga ggacgggttc ggcggcgagg acgagcctgc tccgacggtc
    22021 gatgtcctcg acggtcagcc ggtcgacggc ggcgtccggc cgcagcccgg acagctcggc
    22081 ccgccgccac gacgacgcga tctcgggccg cagcgctgcg ctctccatcc cgcctccctt
    22141 ggcgccgatg accgagccac gctagcaacg gtcaacgagg tgggtcgaga acttgccccc
    22201 gtccgggggt gcccagcacg ccgtgggcga tccgggtgag cgcggcggtg accttctccg
    22261 ggctcaggcc gagctggtgc cgctggtagt cgtagacgtc cggggcgatc ggggcgagca
    22321 gcaggtcggt cagggcgtcc gggtcgtggc cggcttcggt caccagcgcg cgcacgtgcg
    22381 cctgccagaa gccgtaggcg ccggtggtga agcgggcccg gccgatctcc gcgccgagtg
    22441 cgaggtggcc gtgccgctcc agcaggccga ccatcgcgcc gtagaaagcg gcgagccgct
    22501 cgtgcggcgg tgccccgggg ccgagcgggg gctcgccacg cagcaactgc tcctgcaccc
    22561 gccgctcgtg ctcgtcgagc aaggcgagcg cgatcgaggg gacgtccggg taccggcggt
    22621 acagggtgcc ccggcccacc cccgcggcgc gggcgatgtc ctccatcgtg accgaccgct
    22681 ggcggctgaa cagctcctcc gcggcggcga gcacgcgggc ccggttgcgc gccgcgtcgg
    22741 cccgttcctt cggccggtcc gggcgcagca ggtccttccg ttccgtcacc accccagcct
    22801 accgaactgg acacggcgtc cgcttgtggt accgtcgcaa taagtggaca tgatgtccag
    22861 ttcattcggg aggatcgcca tgaccacgtt gctgcacgtc gactccagcg cgcggcgcga
    22921 ctcgttctca cgccggctgg gccaggcctt cgccggtgcc tggcgcgacg cggcgccgga
    22981 cgggcgttac atccaccgcg acctcgccgc ggctccggtg cggccgatcg gccaggcgtg
    23041 gacggaaatc tgcgacaacc tgctgcgcga cggcatcacc gagatcggcc gctacccgga
    23101 ggcggtgcgc acaccggcgc aggaggcggc gtgggcggtc gtggcgcccc tgctggacga
    23161 ggtcgtcacc gccgacgtcg tgctgatcgg ggcgccgatg tacaacttct cgatcccggc
    23221 ggcgctgaag gcgtggctcg accagatcac ctttccgcgg atgtcgttgc ggggcaagcg
    23281 gttcgtcgtc gtgggtgccc gcggcggctc gtacgcgccg ggcacacccc gcgcgccatt
    23341 cgaccaccac gagcggtacc tgcgggactt cttcagcggc cacttcggcg tcgacgaccc
    23401 ggtcttcgtc aacgctgagc tggtcaactc cacggtggat ccgcacctgc ggcacctgcg
    23461 cgaccggcac gaggagtccg ccgcgaacgc actccgggcg gccgcggacc tcggcaagga
    23521 gctggcgctg tgagctgggt tctgctggtg ctcgccgggc tggtcgaggt ggcgtggtcg
    23581 cagagcatca aaccgaccga caacttcacc cggccgtggc cgaccgtgct gtgcttcctg
    23641 ctcgcggcga ccgcggtgta cctgttgtcc cgggcgatga acacgctgcc ggtcggcacc
    23701 gcctacgcgg tgttcaccgg aatcggcgcg gtcggggccg tcgtgctcgg cgtggtggtg
    23761 caccgcgatc ccgtgacgct gggccggggc ctcgcgctgg ccctcatcct gggtggcgtg
    23821 gtgctcgcct acgccacgga cacgggcggg gcgtgatcga tctgttcgcg gaggatgtcg
    23881 ccgtgccccg cgtgccgggc gaattcctcg atcatcgaga gcagcgtcca ccgcatgctg
    23941 accgtgccct cacggggatt gtgcttggtg tcgcccaggt cgaagcgggc ggcgatctcg
    24001 cgggatcgcc ggctcgcgcg ttcgaactcg gcgatcacgt cggccacgga ctcctcgtcc
    24061 gcgacggcga aggtgccctc gtcccgttcc gagtacccgt cgcattcgga cgcgtcgagc
    24121 cccgcccaga accgctggaa ccagatccgc tcggcggccg cggcgtgttt gatcagggag
    24181 aggggtgtgg tgagggaagc gaccagccgg cgccgggcgt cggcttcgga aaggccgcgc
    24241 acggtcacga tcagggccgc ccggttgcgg tcgagcatgt cctcgatgat cgcccgttcg
    24301 gcgccatcgg tgattctgtt gtcgggcatg ggtgtttgat ccgttcgtga ggctggagca
    24361 tcagagggat gtcacacggt cgagcggccc gggctgatcg ccgaacgggc gcgacgtgga
    24421 gaggtgaacc cggccaggac gccggtggcg gtactgaccc gggccggcag taccacggac
    24481 gtacccagcg cttgtctgac aaatcgcccg cgcatccgga aacggcaggg ggaaccacgg
    24541 gctggaccgc tcacggggtg agctgtcggc caagactcat gagctcgtcg acgggcacgg
    24601 ccggccgctg gtggtgctgc tgaccgcggg acaggccggg gactcgccga tgttcctgcc
    24661 cctgatgcgc cacctgtccg tgccgtgtct ggccggagga ccgccgcgga cacggccgaa
    24721 cggggccccg ggcgtgtttc aaagccggca gctcggacga tgcccgcagg ccggccgtgg
    24781 gggcgcgccg acctgaccgc cgcgatcggc gagtggctac ccccgcgtgt gcggtgggca
    24841 acccggtcgg ctttaggcgt catcgccgtc cagtgctcgc gccagtacct gcgccaggtg
    24901 cagcgcctgc cgtccggtga ggtcgtcgat ctgggtgcgg cagctgaagc cgtccgcgag
    24961 gaccatcgtg tcctccggcg cggcctccac ctccggcacc agcacccgcc gcgccgcggc
    25021 gaccgacacc tcgtagtgcc ccttctccac gccgaagttc ccggccagcc cgcagcaccc
    25081 ggagtccagc gtccggttgt ccacccccac ccgccgcaac aaccgctcgt ccgccgcatt
    25141 gcccatcacc gcgtgttgat ggcagtgctg ttgcgtgatc gccgacgcct cgaccgccgg
    25201 gaactccaca tccggcgcgt acttctccag gaactccgcc agcgtgaaca cctgcgacgg
    25261 cagcccgtgc agctcgccgt cgtccagcag ctcccgcgag tcgtgccgga acaccgccag
    25321 gcagctcggc tccaggccca cgatcggcgt gcccgcctcg agttccggcc gcagcacccg
    25381 caacgtccgc cgcagcaccc gccgcgccac gtcgagctgc ccggtcgaga tccaggtcag
    25441 cccgcagcac accgacgacg acggcagcac gacgtcgaac ccggcgtgct ccagcacccg
    25501 caccgcgtcg tgcccgacct cgggcgacag gaagttcgtg aacgtgtccg gccacagcac
    25561 cacgcgcggc cgcccctgct cccgcgcaga gaatccgcgc cggaacgtcc gcggcgcgaa
    25621 ccgcggcagc gaccgctccg gcgtgatccc gcccgccttc ttcaccagcc cggacaaccg
    25681 cccgcccagc acccggttcg ccagccgcgg cgccgccgac gccagccgcg ccagcaccgg
    25741 caggaaaccg agcgtgtagt ggctcgccgg gcgcagccgt cccttgtagt gctggtgcag
    25801 gaactccgcc ttgtacgagg ccatgtccac attgaccgga cagtcggaca ggcatccctt
    25861 gcacgccagg cacaaatcca gtgcctcgag cacctcggtc gaccgccacc cgtcggtgac
    25921 cgtctccccg cgcatcatct cgaacaacag gtgcgaccgc ccgcgcgtgg agtgctcctc
    25981 gcgcccggtg accatgtagc tcgggcacat cacgccggac gatttgtcga cacaggcccc
    26041 gacgccgacg caccgccggg tcgcggtcgc gaggctgccg ccgtcgtgcg ggtacttcag
    26101 cgtgatcggc agcgaccgca ccggcccgtc gaaccgcagg tccgcgtcga gtttccgggg
    26161 ccgcaccagg ttgccggggt tgagcaggtc gccggggtcc cagatcgcct tgaaccgctc
    26221 gaacagcgcc aggatctccg gcgggtacat ccgggacagc agctcggcac gcgcctgccc
    26281 gtcgccgtgc tcgccggaca gcgaaccgcc gtgccgcacc acgagatccg ccgcgtcctc
    26341 catgaacgcc cggaactgcc gccggccgtc ctcggtggtc aggccgaagt tgatgcgcac
    26401 gtgcacgcag ccctcgccga agtgtccata cgggacaccc cgcagcccgt acttccccag
    26461 cagggtccgg aaatcccgga ggtacacgcc gaggttcgcg ggcggcacag cggagtcctc
    26521 ccaccccggc cacgcctcgg acccgtccgg catgcgggtc acgatcccgg ccgcggcctc
    26581 gcgcaccgac cacagcaccc gctggtcggc cggccgcgtc tccaccacgg tcgccgcgcc
    26641 ggtgtcccgc tccaggacag ccgcgacctc ggccgcccgc gccgccgcct cggccggatc
    26701 cgctcccccg acctcgacga acaaccatcc gcgcccggcg ggcagcaggt cgaccgccgg
    26761 gtgggaccgc cgcgtcagca gcgagtcgat caggtcgcgg cccatgccct cgacggtcag
    26821 cggcttcaac ggcagcaccg acggcaccgc gtcggcggcc gcgatgtcgt cggcgtagcc
    26881 cgcgacgacc agcgcacgag ccgcgggagc gggcaccagt cgcacggtga tctcggtcag
    26941 cagcacgcac gtgccctcgg tgccgaccag cgcgcgcacc aggttggtgc cgttctccgg
    27001 cagcagctgg tccagcgcgt acccg
//
