LOCUS       NZ_BNAU01000001        21533 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000001
VERSION     NZ_BNAU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1754180)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1467603
            Orig. end                         :: 1489136
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21533
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21533
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21533
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11533](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11533
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            201..776
                     /locus_tag="IE290_RS07190"
                     /old_locus_tag="GCM10017786_14700"
     CDS             201..776
                     /EC_number="3.6.1.55"
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003986 - acetyl-CoA hydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008413 - 8-oxo-7,8-dihydroguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_function="GO:0010945 - coenzyme A diphosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0035539 - 8-oxo-7,8-dihydrodeoxyguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0015938 - coenzyme A catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987993.1"
                     /locus_tag="IE290_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14700"
                     /product="CoA pyrophosphatase"
                     /protein_id="WP_191243642.1"
                     /transl_table=11
                     /translation="MRTDVIEAFPRVAVPLDGRRAAAVAIVVAGDEPVIWVTRRASRMR
                     AHPGQFALPGGRVDPGEDAIGAALRELEEELGVAAERADCVGVLDDYPTRSGYVITPVV
                     VRLPGAVRLRPNPDEVARVHVVGLRELAVEPRFLTIPESDRPVIQLPLAGHLVHAPTAA
                     VLYQFREAALYGRTTRVAHLEQPVFAWR"
     gene            complement(1086..1259)
                     /locus_tag="IE290_RS07195"
                     /old_locus_tag="GCM10017786_14710"
     CDS             complement(1086..1259)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987992.1"
                     /locus_tag="IE290_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14710"
                     /product="hypothetical protein"
                     /protein_id="WP_191243643.1"
                     /transl_table=11
                     /translation="MAYKITHVSRAQEIRFPTQAAAEHYADRLGGGLENWQVREAGAEP
                     PTAPAAEAPQHG"
     misc_feature    1325..1340
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.04"
                     /tool="antismash"
     misc_feature    complement(1326..1339)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.25"
                     /tool="antismash"
     misc_feature    complement(1374..1387)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.86"
                     /tool="antismash"
     misc_feature    1375..1384
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.35"
                     /tool="antismash"
     gene            complement(1407..2399)
                     /locus_tag="IE290_RS07200"
                     /old_locus_tag="GCM10017786_14720"
     CDS             complement(1407..2399)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227551.1"
                     /locus_tag="IE290_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14720"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_191243644.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.8e-12, bitscore:
                     42.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6e-09, bitscore:
                     33.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDHTVLLDSVIESTIAPQADQVDRAGCFPRSGISALGEVGLLGL
                     ASAPAVGGGGAGLAETARVVERVAGVCGSTAMVLLTHYAATALVEAHGPPEVRGAIARG
                     EHLITLALGAPSDRCTVRAAELDGVKSWVVAAGEADSYVWTCDSGAVLVGGAVPGLRIG
                     APFDGVGLRGSAATSVTADHVAIPAGSVVADGLAVALPGFLVLGTAFTLGLIEAMLAAG
                     HVPGRPEFTALRTRTDLLRAFFDDTVAAVTTGRPDAMVRAVQARLVAAETATEVGDRLL
                     RLCGFAAARKDVSVERHFRDALTARVMTPTGESLEEIIGRDAVGQPLFR"
     gene            2504..3496
                     /locus_tag="IE290_RS07205"
                     /old_locus_tag="GCM10017786_14730"
     CDS             2504..3496
                     /NRPS_PKS="Domain: PKS_KR (1-169). E-value: 8.7e-17. Score:
                     53.5. Matches aSDomain:
                     nrpspksdomains_IE290_RS07205_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659562.1"
                     /locus_tag="IE290_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14730"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_191243645.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-34, bitscore:
                     115.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVVVVTGASGGVGRATARAFAERGDDVALLARGEAGLRAAAREV
                     EEAGRRALPIQVDVADFAAVDRAASRAEAELGPVDVWVNAAFSGVFAPFTEVAPEEFRR
                     VTEVTYLGFVHGTRAALDRMRPRDRGVIVQAGSALAYRGIPLQSAYCGAKHAIQGFTES
                     LRCELLHERSGVRVTMVQLPGMNTPQFDWVLSRLPRRAQPVAPVYQPEVAARAIVHAAE
                     HPGRREYWVGGSTVATLLGDKFAPGLLDRYLARTGYGSQQAEQRRDPRQPANLWTPADE
                     RRDFGAHGRFDRRAVRRMVQPWASRHHGLLGAAGLLLATVGGVLARARR"
     aSDomain        2507..3010
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE290_RS07205_PKS_KR.1"
                     /evalue="8.70E-17"
                     /label="IE290_RS07205_PKS_KR.1"
                     /locus_tag="IE290_RS07205"
                     /protein_end="169"
                     /protein_start="1"
                     /score="53.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GVVVVTGASGGVGRATARAFAERGDDVALLARGEAGLRAAAREVE
                     EAGRRALPIQVDVADFAAVDRAASRAEAELGPVDVWVNAAFSGVFAPFTEVAPEEFRRV
                     TEVTYLGFVHGTRAALDRMRPRDRGVIVQAGSALAYRGIPLQSAYCGAKHAIQGFTESL
                     RCELL"
     CDS_motif       2513..2581
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE290_RS07205_0001"
                     /evalue="9.60E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE290_RS07205"
                     /protein_end="26"
                     /protein_start="3"
                     /score="21.5"
                     /tool="antismash"
                     /translation="VVVTGASGGVGRATARAFAERGD"
     gene            complement(4017..5309)
                     /locus_tag="IE290_RS07210"
                     /old_locus_tag="GCM10017786_14740"
     CDS             complement(4017..5309)
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987990.1"
                     /locus_tag="IE290_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14740"
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="WP_191243646.1"
                     /transl_table=11
                     /translation="MPFTDRRDAGRRLAARLDRWRGSDVVVLGLPRGGVPVAAEVARVL
                     GAPLDVVLVRKLGLPFQPELALGAIGEGGLRLVDPDLVRRFGISAAELAAVEAAERSEL
                     DRRAARFRAGRAPVPLAGRTAIVVDDGMATGASARVAVAAARAAGARRVVVAVPVAARQ
                     AVAALREDADDVVCLECPAAFTAVGQWYDDFTQTPDEEVARLLAGEPGDPDPATSDEEV
                     TVFVGAVPLGGRLTVPECAAGIVVFAHGSGTGRYSPRARSAAEPLHRAGIATLLVDLLT
                     PSEEADRARVFAVELLASRLVEVTRWVRARTGLPVGYFGTGTGAAAALLAATDYRVEVA
                     AVVARGGRPDLAAKRLGWVRTPTMLIAGARDAAEVELHRTAHTQLRGEAHLAVVPGATH
                     LFEEPGTLDAAACLARDWFRRHLTPVTIEGG"
     gene            complement(5430..6752)
                     /gene="hmgA"
                     /locus_tag="IE290_RS07215"
                     /old_locus_tag="GCM10017786_14750"
     CDS             complement(5430..6752)
                     /EC_number="1.13.11.5"
                     /GO_function="GO:0004411 - homogentisate 1,2-dioxygenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006559 - L-phenylalanine catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006572 - tyrosine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hmgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019920929.1"
                     /locus_tag="IE290_RS07215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14750"
                     /product="homogentisate 1,2-dioxygenase"
                     /protein_id="WP_191243647.1"
                     /transl_table=11
                     /translation="MTSTIEPGVRAGTELAYLTGFGNEHHSEAVPGALPVGRNSPQRAP
                     LGLYAEQHSATAFTEPRAHNRRSWVYRIRPSAAHPPFHPIEHPTLRSAPVIDGVPDPNR
                     MRWDPVPFPDEPADFVDGLYTVGATGNVLQRAGIGIHVYRANRSMTDRCFVDADGELLV
                     VPELGGLMVHTEYGRLRVEPGEIAVIGRGVRFRVDLLGDRARGYVCENYGQPFTLPELG
                     PIGANGLANPRDFQYPVAAFEDREATVEVVQKFGGRLWAAEYDHSPLDVVAWHGNHAAY
                     KYDTARFNVMGTVSYDHPDPSIYTVLTSPSELPGQANADFVVFAPRWLVGEDTFRPPWY
                     HRNVMSEFMGLVKGVYDAKAEGFVPGGASLHNMWSAHGPDAATYAKASTQELVPQKIDD
                     TLAFMFETRWPVVTTGFAASAAHRQPDYDAVWRGIRREFTG"
     gene            complement(6846..8177)
                     /locus_tag="IE290_RS07220"
                     /old_locus_tag="GCM10017786_14760"
     CDS             complement(6846..8177)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420676.1"
                     /locus_tag="IE290_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14760"
                     /product="carboxylesterase/lipase family protein"
                     /protein_id="WP_191243648.1"
                     /transl_table=11
                     /translation="MDTVVAAGRGKLRGFVTADGLAEFRGIPFARAPRFAPPEPAEPWT
                     GVRDATRHGPVSPQPPVRPDGVMGVPAEVPDQDEDCLNLTVITPAPDDRKRPVMVWLHG
                     GAYVTGANSFGFYGGHRLVTEGDVVFVAPNYRLGALGYLRLPGVSPGNLGLLDQLAALR
                     WVRENAAAFGGDPDDVTVFGQSAGAHSIACLMALPEARGLFRRAILQSAPLGLRLAGAR
                     TAARTARLFTTALGGDPRTAPVAEILRAQNETIVKAAGPGGLYSVPPFCPVADAPPLPS
                     VTHWLSQRARFAPDVDVLIGTTAAEMNSFLTGKPGFARLERIPVTARGVAAVKAGITRW
                     MFGAPSRAFADQLAARGGRVYSYVFDWGAPDSPYGAGHCVELPFLLGDETAWRAAPMLA
                     GAEWTTLSELGRELRAAWLSFARTGVPSPGWPRHTPKRAPHRLP"
     gene            complement(8239..8841)
                     /locus_tag="IE290_RS07225"
                     /old_locus_tag="GCM10017786_14770"
     CDS             complement(8239..8841)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013964.5"
                     /locus_tag="IE290_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14770"
                     /product="HNH endonuclease"
                     /protein_id="WP_191243649.1"
                     /transl_table=11
                     /translation="MVRTTGGNAAGYPDVLHDVVRALIRQDRAAADARMGAIAEPIRPP
                     VPRRTPSIRVRAGIFERDRYQCRYCGVPTVLTPVMRLVSTAYPREFPYHRNWKAGEVHP
                     AIETISATHDHVIPVTRGGDPLDPGNIVTACWVCNSAKGNLPLDALGWTLRAPADDGWH
                     GLADRYADLWEALGRPPLGADEAHWMAATRRLYPRPS"
     gene            complement(8878..9786)
                     /locus_tag="IE290_RS07230"
                     /old_locus_tag="GCM10017786_14780"
     CDS             complement(8878..9786)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420677.1"
                     /locus_tag="IE290_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14780"
                     /product="proteasome assembly chaperone family protein"
                     /protein_id="WP_191243650.1"
                     /transl_table=11
                     /translation="MVFDPTDLYEVDSELPELSGAVLLHQLDGFMDAGQAGTLVSEHLK
                     TNWDNRVVARFDVDRLIDYRARRPVMTFDTDHWESYDTPELAVRLFHDEAGTPFLLLSG
                     PEPDAMWERYAAAVRTLVERWDVRMTVSFHGIPMGAPHTRPLGVTAHATRRELIGDYEP
                     VLNRLEVPGSALNLTEFRLGEAGHDAVGFAAHVPHYLAQSRYPAAALTVLGSITRLAGL
                     SLPDEALRAASRRTDAEIARQVAESDEVADVVHALERQYDLFVEAMDGKKTLLADESSM
                     PTAEELGAEFERFLAEQDRRD"
     gene            10001..11533
                     /locus_tag="IE290_RS07235"
                     /old_locus_tag="GCM10017786_14790"
     CDS             10001..11533
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987985.1"
                     /locus_tag="IE290_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14790"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_191243651.1"
                     /sec_met_domain="T2TS (E-value: 7.5e-93, bitscore: 308.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADLAEHAHHLLRAMVTDPYGDFSPSVYETARLVSLLPALAGHA
                     DRVAFLLGQQAADGGWGGPEGYGLLPTLSATEALLTEFRRTGAPAAAAAAEQGLRALFT
                     RWGPDLRVRLPDTVAVEILVPSLVSELNAHLDALTADDIVLAGGRRLPHPEGTHPALLE
                     ELRRLAEAGQALPDKILHSLEALGPAAHGAGFARPGENGLGCSPAATAAWLGGDVAAGR
                     PGVRYLENVQARHGGAVPVAAPLTVFERSWVLSTFADAGLAVTVPDEVLDGLAAEIGPH
                     GLAGGAGLPPDADDTSTALYALAAQGRPHPLDCLREYHVDGHFCTYPDERTPSVTTNAH
                     VLQALCANGPSEVAGRVASWIVDQQHPDGSWTDKWHASPYYATARCFLALAGSGRGVTA
                     RERALRWIATTQRPDGSWGRWQGTFEETAYAVQVLARAGEPWADEAAARGCAFLLSWPE
                     AAHPPLWHDKDLYTPGRIVRAEGIAALHLARRRPRIAALLTRLEPAPAERTA"
     gene            11534..12766
                     /locus_tag="IE290_RS07240"
                     /old_locus_tag="GCM10017786_14800"
     CDS             11534..12766
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420679.1"
                     /locus_tag="IE290_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14800"
                     /product="cytochrome P450"
                     /protein_id="WP_191243652.1"
                     /sec_met_domain="p450 (E-value: 4e-50, bitscore: 167.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVELALAATPLRFLDAHADDPAAMLDVRTGEAPKILVWHHDAL
                     TSLFRQDAHLRHPGSRSLAPLLGPKSMLWADGTRHAAYRKLLGAPLRGRRLRDYHGLIA
                     QAAAAAIDALDAGTVFGLAAWTRRLALDIVARIILGAADPVLLRDVTAWLDHALGSRRR
                     TLAHRFLRGGLPASGAELDARLVAAAKSDRRNLVSPLLTGNGPLGPVPDDELRDQVVSL
                     LFAGHETTASATAWTLYWLTRRADLREAVLSELAATTGDGSDPAEVPVLQAVISEALRL
                     HPPVEVAGNRTLPEPVELLGRTLPAGTVLTPAIYLAHHRSEYFPSPHSFDPGRFLGRRG
                     VPEGYLPFGGGTRFCLGSQLGQLEIRMVTAALLRRRVLRCVNPRAGVAKLRGHAMAPSA
                     RLRVEVVACRD"
     gene            12754..13641
                     /locus_tag="IE290_RS07245"
                     /old_locus_tag="GCM10017786_14810"
     CDS             12754..13641
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420680.1"
                     /locus_tag="IE290_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14810"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_191243653.1"
                     /transl_table=11
                     /translation="MPGLTWWQDVVLVHRLHFPLPLSYLAYACWGAAFADPRHLLGGPV
                     LLSVAATLLVLLAALALNTAADLRTDEQDRDKTALAGAARRIGSGRIFAWAAAEAAAAI
                     ALGAAVAVWLGRWAALLVITAALAAHLAYNLEPVRLKRRGFAGPAVFGAGFLAVPGLAS
                     YFAVRPALERSMVPVLAGLCVLAFGRTAWFSAPDHAADARSGVRTPGARYGPRRTLVIS
                     CGVVVAGLAVLGCGLWWRYGPGWAVAGVVAEGAFLTGMVALAGPRGSFSRMRKLATPAV
                     LAGDLTLVAIPLLA"
     gene            complement(13610..14488)
                     /gene="mmuM"
                     /locus_tag="IE290_RS07250"
                     /old_locus_tag="GCM10017786_14820"
     CDS             complement(13610..14488)
                     /EC_number="2.1.1.10"
                     /GO_function="GO:0047150 - betaine-homocysteine
                     S-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mmuM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420681.1"
                     /locus_tag="IE290_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14820"
                     /product="homocysteine S-methyltransferase"
                     /protein_id="WP_191243654.1"
                     /transl_table=11
                     /translation="MTVVLDGGLATELEARGHDLSGELWSARLLADDPGAIVAAHRAFF
                     RAGARIATTASYQASLGGFAELGLDRDESVRLLELSVELAREARLTGDELVAASIGPYG
                     ATLADGSEYRGHYGLSVAELTAFHRPRAEILAAAGPDLLGCETVPDVDEAEAILLAIEG
                     LGVPAWLSYTIEGESTRAGQPLTEAFSVVRGNDQIVAVGVNCCDPRDVAVAAEIAREAS
                     GKPVIVYPNSGETWDARTRGWTGQARFSPEAVRDWLAAGVEYVGGCCRVSPDDIAALAA
                     VVTPGAGSPPA"
     gene            complement(14485..15108)
                     /locus_tag="IE290_RS07255"
                     /old_locus_tag="GCM10017786_14830"
     CDS             complement(14485..15108)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987981.1"
                     /locus_tag="IE290_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14830"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_191243655.1"
                     /transl_table=11
                     /translation="MTGISTPARNTFREQQWREAHDRYLECAREVFARLGYHAATVADI
                     VAAANGSRATFYAHFRDKADIAAALFERILPDTAALYRMLAHFPELTRDRVRTWLDEHV
                     LAFWTRYAVEIDVLTQAVADDPRVAARHYQWGVDAARELAPYLTQWTGEHEQAGLTRAL
                     LLVLQLEQACYHWLIRGVGHDRALVLDVLADVWWRELTFLRTGP"
     misc_feature    complement(15093..15107)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
     misc_feature    complement(15228..15243)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            15355..16446
                     /locus_tag="IE290_RS07260"
                     /old_locus_tag="GCM10017786_14840"
     CDS             15355..16446
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420683.1"
                     /locus_tag="IE290_RS07260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14840"
                     /product="DNA-binding transcriptional regulator"
                     /protein_id="WP_191243656.1"
                     /transl_table=11
                     /translation="MAAGTNPPGAATAQQWTGREARLLRHALRLSVRGFAAYLGVAART
                     VAKWESGGTSTVPRPDTQAILDTALARADAGARTRFEVLVTQAQEAGRAPEPAPRYDYE
                     AWTDDLDRTVACLGRQEFRLARTLLDRWLARFEPNSSDRQGMYLYGRSLRLLGEVRQDQ
                     GALRGPLSAEHVYRQALRVFTELESPRRVAQLELQLVVIDEMSGQLDAAAARYESLTAD
                     ERLSPHDRTRARLWVGTALSKRGLHETATHHIVPAIREFEALEEPADWSIAHQKLALAH
                     RGAGDLTAAGRAIDVALTNRVDDTPLQQVRLETAHAHILLSDTATADSGLAILDRTARI
                     STRYGLMHQLRSIDSIRRRFESR"
     gene            16454..17107
                     /locus_tag="IE290_RS07265"
                     /old_locus_tag="GCM10017786_14850"
     CDS             16454..17107
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987979.1"
                     /locus_tag="IE290_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14850"
                     /product="YdcF family protein"
                     /protein_id="WP_191243657.1"
                     /transl_table=11
                     /translation="MRKALLDTVWADAELVWEFHRLRHRPKPCSAAVALGCNDLGVAAH
                     AAELYHRGLFPVVVFSGGNSRETARAFPRGEGVHYRERALELGVPDEAILVEPHATNTG
                     ENITLSREVLAAAGIEVSSLMLVSMPYMERRAFATTRKVWPEVEPVCASAPVSLTEYAL
                     RTQHGTELIDMIVGDFQRLIEYPRKGFAIPQKIPPIVYSAYRRLVVAGFRSRML"
     gene            17121..17837
                     /locus_tag="IE290_RS07270"
                     /old_locus_tag="GCM10017786_14860"
     CDS             17121..17837
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987978.1"
                     /locus_tag="IE290_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14860"
                     /product="WbqC family protein"
                     /protein_id="WP_191243658.1"
                     /transl_table=11
                     /translation="MPETLSCAVHQPNLFPRLSTLGKLVRADVWVVLDDVQFNARDYQH
                     RARLAAPADPEAQRWLTVPVHRPRGRDSRIGELLLADPAGTHRTVSRLVRQYYGRCAHW
                     PETGELVEEVLAALALNERPAVVAEVSVRAMLHRLGWRGAVVRSSDLPSREGRSQRLAD
                     LTAAVGAGTYLCGPGGAKYLSEGPFLERGLQVRYPPPPPLTRERGMRTASALWAFAQRG
                     AAGVRDALAVDCVPAR"
     gene            17918..20023
                     /locus_tag="IE290_RS07275"
                     /old_locus_tag="GCM10017786_14870"
     CDS             17918..20023
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420686.1"
                     /locus_tag="IE290_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_14870"
                     /product="transglycosylase domain-containing protein"
                     /protein_id="WP_191243659.1"
                     /transl_table=11
                     /translation="MRLSRGVPRFLAFCAVAGVLVAGVAAPVALGAGVLSNQVADAVDG
                     LSATLANSEQPLVTTVTDRDGTPIATLFDQYRLPVTAGQIAPAMKAAIVSIEDRRFYDE
                     GGVDVKGMVRAALHDSSGGSTQGGSTITQQYVKNYLINVVDRNDRAAQLADQADTIARK
                     LREAKIAVQLGQTVSKEDILTGYLDVVEFTGNIYGVGAAAHAYFGTTPDKLTVPQAALL
                     AGMVNNPNLFNPYTHPDQALQRRNLVIDAMVSTKTLTAADGATAKAAPLGVLPDGPDVP
                     SSTCLGAAPDAGFFCQYAESYLIQSGFTADQLETGGYVIRTTLDPRVSRIAKAAVDANV
                     PTTQDGVANTFAVIRPGQTTHEVLAMVANRDYGTDPARGETSTNIVAGASNVFGAGSSF
                     KIFTSAAALESGKAGLDTPLPNQAGQCFAQPGANKYTPPYCVQNDGVNYPDPISLRDGL
                     ATSPNVAFVNLEQQVGMPAVLDMARRLGLRNTLTTNDAGAKPDPSSPNPQYSQPQSQYF
                     QDKLSFTLGNSPVSPLEMANVSATLMSGGTWCPPDPILSVTDRYGHDVPVRQQACEQVV
                     PPGLADSLLNGLSQDTVSGTSAAAAAAAGWHHADFGKTGTTQQSESVAFVGGVDDYAVS
                     SMVFADGPHPAEICPGTPVHLGSCGHGAFGGTVAAPPYFHAMNQILGGRPDTPIPAADP
                     AYLRARG"
     misc_feature    20890..20905
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.23"
                     /tool="antismash"
     misc_feature    20927..20941
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
ORIGIN
        1 gtcgacgccg ccggagatcc ggccgagcca cacgtggtag acgaccacga ggacgcaggc
       61 gagcgcgcgc aggccgtcga tctcggggcg gtaccgggta cgggggtggg gcggggtcat
      121 cggcaccttt cctcactcgg cgttcccggc gagatcgaga ttacccacgg ccgtggcgcg
      181 ctccggctag ggtcggcggg gtgcggaccg acgtgatcga ggcgttcccg cgggtggccg
      241 tgccgctgga cgggcgccgc gcggcagcgg tcgcgatcgt ggtggccggg gacgagccgg
      301 tgatctgggt gacccgccgg gcgagcagga tgagggcgca tcccgggcag ttcgcgttgc
      361 cgggcggccg ggtcgacccg ggtgaggacg cgatcggggc ggcgctgcgc gagctcgagg
      421 aggagctggg ggtggccgcg gagcgcgcgg actgcgtcgg cgtgctcgac gactacccga
      481 cgcgctcggg gtacgtgatc acgccggtgg tcgtgcggtt gccgggcgcg gtgcggctgc
      541 gcccgaaccc ggacgaggtg gcgcgggtgc atgtggtggg actgcgggag ctggcggtgg
      601 agccgcggtt cctgacgatc ccggagtcgg accggccggt gatccagctg ccgctcgcgg
      661 gccacctggt gcacgccccg acggcggcgg tgctgtacca gttccgggag gccgcgctgt
      721 acggccgcac cacgagggtc gcgcacctgg agcagccggt gttcgcgtgg cggtgaggcc
      781 gccgttccgg cggtggagcg ccgggcggca ggcgcccacg gccaccggct ggtcccggca
      841 atgacgttgg atcgatccca ccttgaggaa aaggccggat gtccacgggc acgaacccgc
      901 ctgaggcggg cccagccgcg gcgcccggcg cctcagtcgg cagagccgca ttccgcgccg
      961 cgggctgagc gggcgcctac gcgccgcccg cgcgggctca gcgcgggcgc ccactccgcg
     1021 atcgtgccga tgcctcagcg cccgggagag ccgcggctca gcaccctggg cgccaacccc
     1081 cggcgtcagc cgtgctgggg ggcctccgcc gccggcgcgg tgggcggctc cgcacccgct
     1141 tcgcggacct gccagttctc cagtccgccg ccgaggcggt cggcgtagtg ctccgccgcc
     1201 gcctgggtcg ggaaccggat ctcctgcgcg cgcgacacgt gcgtgatctt gtaggccatc
     1261 accactcccc tgcccctgtc gttctttcgc ggcccgtcac tccccgaccg gccgcgtcga
     1321 acagtagaac acctgttcga cgacacgcaa gccgacacgc cggtctccgg cagggaattt
     1381 ttgatcgtcc actcaggaca ttcacctcag cggaatagtg gctggccaac ggcatcccgg
     1441 ccgatgatct cctccagcga ctcacccgtg ggggtcatca ccctcgcggt gagcgcgtcc
     1501 cggaagtggc gctcgacgct cacgtccttg cgcgccgccg cgaagccgca cagccggagc
     1561 agccggtcgc cgacctcggt ggccgtctcc gcggcgacca gccgcgcctg caccgcgcgc
     1621 accatcgcgt cggggcggcc ggtggtgacc gcggcgacgg tgtcgtcgaa gaacgcgcgc
     1681 agcaggtcgg tccgcgtgcg cagcgcggtg aactccggcc gtcccggaac gtgcccggcc
     1741 gcgagcatcg cctcgatcag gccgagtgtg aacgcggtgc cgagcaccag gaagcccggc
     1801 agcgcgaccg ccagaccatc cgcgaccacg gagccggccg ggatcgcgac gtggtccgcg
     1861 gtcaccgagg tcgcggcgct gccgcgcagg ccgaccccgt cgaacggcgc gccgatccgc
     1921 agacccggca cggcgccgcc gaccagcacg gccccggagt cacaggtcca cacgtagctg
     1981 tccgcctcgc ccgcggccac cacccagctc ttgaccccgt ccagctcggc ggcccgcacg
     2041 gtgcaccggt cgctgggagc gccgagtgcg agcgtgatca gatgctcccc gcgggcgatc
     2101 gcgccgcgca cttcgggcgg gccgtgcgcc tccaccagcg cggtggcggc gtagtgggtg
     2161 aggagcacca tcgcggtcga gccgcacacc ccggcgacgc gttcgaccac gcgcgcggtc
     2221 tcggcgagac cggcgccccc gccgcccacc gctggcgcgc tggccaatcc cagcagcccg
     2281 acctcaccga gcgcgctgat ccccgaccgc gggaagcacc cggcgcggtc gacctggtcg
     2341 gcctgcgggg cgatcgtcga ctcgatcacc gaatcgagca gaacggtgtg gtcgagcatc
     2401 ggccaccacc tagcgtgcgg ggatgcggac actgcgttac tacccggcgg ccgccccgga
     2461 aaaccaccgg atagggccgc ccccgcccgg gtagccggga ggcatgggag tcgtggtggt
     2521 gacgggagcc agcggcgggg tcggccgggc gacggcgcgg gcgttcgccg aacggggtga
     2581 cgacgtcgcg ctgctcgccc gcggcgaggc ggggttgcgg gccgccgcgc gggaggtcga
     2641 ggaggccggg aggcgggcgc tgccgatcca ggtcgacgtg gccgacttcg cggccgtcga
     2701 ccgcgcggcg agccgggccg aggcggagct ggggcctgtc gacgtgtggg tcaacgcggc
     2761 gttcagcggg gtgttcgcgc cgttcacgga ggtggcgccg gaggagttcc gccgggtcac
     2821 ggaggtgacc tacctggggt tcgtgcacgg cacgcgggcg gcgctggacc ggatgcggcc
     2881 gcgggaccgg ggcgtgatcg tgcaggccgg gtcggcgctg gcctaccgcg gcatcccgct
     2941 gcagtcggcc tactgcgggg cgaagcacgc gatccagggg ttcaccgagt cgctgcggtg
     3001 cgagctgctg cacgagcggt ccggggtgcg ggtgacgatg gtgcagctgc ccgggatgaa
     3061 cacgccgcag ttcgactggg tgctctcgcg gctgccgcgg cgggcgcagc cggtcgcgcc
     3121 ggtgtaccag ccggaggtcg cggcgcgggc gatcgtgcac gccgccgagc accccgggcg
     3181 gcgcgagtac tgggtcggcg gctcgacggt ggccaccctg ctcggcgaca agttcgcgcc
     3241 cgggctgctg gaccgctacc tggcccgcac gggctacgga tcgcagcagg cggagcagcg
     3301 gcgcgacccg cggcagccgg cgaacctgtg gaccccggcc gacgagcgcc gcgacttcgg
     3361 cgcgcacggc cgtttcgacc gccgcgccgt gcggcggatg gtgcagccgt gggcctcccg
     3421 gcaccatggc ctgctgggcg cggccgggct gctgctcgcc accgtgggtg gggtgctcgc
     3481 tcgcgcgcgc cgctgaccgc cgtgctgggg ggtgcggcag gtgcctgatc gctcgcgccg
     3541 cggtgggagc cgcctggcgg caccacaggg ggcaggactg ctgctcgcca ccttgggcgg
     3601 tagtcgctcg cgcgccgctg accgcgccca cgcggcgccg cccgccgcag gcgccacccg
     3661 acggcaccgc tgccccgacc gccgcgccgt gcggcggatg gtgcagccag gggcttcccg
     3721 gcaccacggc ccgctcagcg cggccggact gctgctcgcc accctgggcg gcagtcactc
     3781 gcgcgccgct gaccgcgccc acgccgcgcc gcccgccgca ggcgccaccc ggcggcaccg
     3841 ctgcccgacc gccgcgccgt gcggcggatg gtgcagccag gggcttcccg gcaccacggc
     3901 ctgctcggcg cggccgggct gctgctcgcc accctgcgtg gggtgctcgc ccgcgcccgc
     3961 cgctgacgcg agtccaccgc ctgccgcagc agagggcctc gccccggacg ccccagttaa
     4021 ccgccctcga tggtcaccgg cgtcaagtgc cttcggaacc agtcgcgagc caggcaggcc
     4081 gccgcgtcga gcgtgcccgg ctcctcgaac aggtgcgtcg ccccggggac gaccgccagg
     4141 tgcgcctcgc cgcggagctg ggtgtgcgcg gtccggtgca gctccacttc ggcggcgtcg
     4201 cgggcgcccg cgatcagcat cgtcggcgtg cggacccatc ccaggcgctt cgccgccagg
     4261 tcgggccgtc cgccgcgcgc caccaccgcc gccacctcca cccggtagtc cgtcgccgcc
     4321 agcagcgccg ccgcggcccc ggtgcccgtg ccgaagtacc cgaccggcag gcccgtccgc
     4381 gcgcgcaccc accgcgtcac ctccaccagc cggctcgcca gcagttcgac ggcgaacacc
     4441 cgcgcccggt cggcctcctc gctcggcgtc agcaggtcca ccagcagcgt cgcgatcccc
     4501 gcccggtgca gcggttccgc cgccgaccgc gcccgcgggc tgtaccggcc ggtgccactg
     4561 ccgtgcgcga acaccacgat ccccgccgca cactccggca ccgtcagccg cccgccgagg
     4621 ggcaccgccc cgacgaacac ggtgacctcc tcgtcgctcg tcgccgggtc cggatcaccg
     4681 ggctcgcccg ccagcagccg cgcgacctcc tcgtccgggg tctgcgtgaa gtcgtcgtac
     4741 cactgcccca ccgcggtgaa cgccgccggg cactccaggc acaccacgtc gtcggcgtcc
     4801 tcgcgcagcg ccgccaccgc ctgccgcgcc gcgaccggca ccgcgaccac gacccgccgc
     4861 gcccccgccg cccgcgcggc cgccaccgcg acccgcgcgc tggctccggt cgccatcccg
     4921 tcgtcgacga cgatcgcggt gcgtcccgcc agcggcaccg gcgcccgccc ggcccggaac
     4981 cgcgcggcgc gacggtccag ttcggaccgt tccgccgcct ccaccgccgc cagctccgcc
     5041 gcgctgatcc cgaaccgccg caccagatcg gggtccacca ggcgcagccc gccctcgccg
     5101 atcgcgccca gcgcgagctc cggctggaac ggcaggccca gcttgcgcac caggaccacg
     5161 tccagcggcg cgccgagcac gcgggccacc tcggccgcga ccggcacacc cccacggggc
     5221 agcccgagca ccaccacgtc gctgcctcgc caccggtcca gtcgcgccgc gaggcggcga
     5281 ccggcgtccc tccggtcggt gaacggcatc ggagtacctc ctccgcgaag ttctccggcg
     5341 accgtatcgg cgccgccggt ccgcggcgag agtcctaggg ccccactggg ccgaacggcg
     5401 gcacggcaac cgccgcgcac cgtccgtgct cagccggtga actcacgccg gatcccgcgc
     5461 cacacggcgt cataatcggg ttgccggtgc gcggccgacg cggcgaagcc cgtcgtcacc
     5521 acgggccagc gcgtctcgaa catgaacgcg agcgtgtcgt cgatcttctg cggcaccagc
     5581 tcctgcgtgc tggccttggc gtaggtggcg gcgtccgggc cgtgcgccga ccacatgttg
     5641 tgcaggctcg ccccgcccgg cacgaaccct tcggccttgg cgtcgtagac gcccttgacc
     5701 aggcccatga actcgctcat cacgttgcgg tggtaccagg gcggccggaa ggtgtcctcg
     5761 ccgacgagcc agcgcggcgc gaagaccacg aagtccgcgt tggcctgccc gggcagttcc
     5821 gacggcgagg tcagcaccgt gtagatcgac gggtcggggt ggtcgtagct gacagtgccc
     5881 atcacgttga accgcgcagt gtcgtacttg taggcggcgt ggttgccgtg ccaggccacg
     5941 acgtccagcg gcgagtggtc gtactcggcc gcccacagcc ggccgccgaa cttctgcacc
     6001 acctcgacgg tcgcctcgcg gtcctcgaac gccgcgaccg ggtactggaa gtcgcgcggg
     6061 ttggccagtc cgttggcgcc gatcggcccg agctcgggca gggtgaacgg ctggccgtag
     6121 ttctcgcaca cgtagccgcg cgcgcggtcg ccgagcaggt cgacgcggaa ccggacgccg
     6181 cggccgatca ccgcgatctc ccccggttcg acgcgcagcc tgccgtattc ggtgtggacc
     6241 atcagtccac cgagttccgg caccaccagc agttccccgt ccgcgtcgac gaagcagcgg
     6301 tcggtcatgg agcggttcgc gcggtagacg tggatgccga tgccggcgcg ctgcaggacg
     6361 ttgccggtgg cgccgacggt gtagaggccg tcgacgaaat cggccggctc gtccgggaac
     6421 ggcaccgggt cccagcgcat ccggttcggg tcgggcacgc cgtcgatcac cggcgcgctg
     6481 cgcagcgtcg gatgctcgat cgggtgaaac ggcggatgcg cggcggaggg ccggatgcgg
     6541 tagacccagc tgcgccggtt gtgcgcgcgc ggctcggtga aggcggtggc gctgtgctgt
     6601 tcggcgtaga gcccgagcgg cgcgcgctgc ggggagttgc ggccgaccgg cagggcgccg
     6661 gggaccgcct cgctgtggtg ctcgttgccg aagcccgtca ggtacgccag ctccgtgccc
     6721 gcccggacgc ccggctcgat cgtgctcgtc atcgtgcaca ccccaccctg gtcggctgct
     6781 gagctgacta ccagcgtcgt cgggtggcgc acgcgggtca acttcggcgg cgcgcttgcc
     6841 ggtggtcagg gcagccggtg cggggcgcgc ttcggtgtgt gccgcggcca ccccggggac
     6901 gggacgccgg tgcgggcgaa ggacagccac gccgcccgca gctcgcggcc cagctcgctc
     6961 agcgtcgtcc actccgcgcc cgccagcatc ggcgccgcgc gccacgccgt ctcgtcgccg
     7021 agcaggaacg gcagctccac gcagtgcccg gcgccgtacg gcgagtccgg cgcgccccag
     7081 tcgaacacgt agctgtacac ccgcccgccc cgcgcggcga gctggtcggc gaaggcccgc
     7141 gagggcgcgc cgaacatcca ccgcgtgatg ccggccttca ccgccgccac cccgcgcgcg
     7201 gtgaccggga tccgttccag ccgggcgaaa cccggcttgc cggtgaggaa cgagttcatc
     7261 tcggccgccg tggtgccgat cagcacgtcc acgtccgggg cgaaccgcgc ccgctgcgac
     7321 agccagtgcg tcacgctcgg cagcggtggc gcgtcggcga ccgggcagaa cggcggcacc
     7381 gagtacagcc cgcccggccc ggcggccttg acgatggtct cgttctgggc ccgcaggatc
     7441 tccgccaccg gcgccgtccg cgggtccccg cccagggcgg tggtgaacaa ccgcgccgtg
     7501 cgcgcggcgg tgcgggcgcc ggccagccgc aggcccagcg gcgcgctctg caggatcgcc
     7561 cgccggaaca ggccgcgcgc ctcgggcagt gccatcaggc acgcgatcga atgcgccccc
     7621 gccgactgcc cgaacacggt gacgtcgtcc gggtcgccgc cgaaggccgc cgcgttctcc
     7681 cgcacccagc gcagcgcggc gagctggtcc agcaggccga ggttgcccgg cgaaaccccg
     7741 ggcaggcgca ggtagccgag cgcgccgagc cggtagttgg gcgccacgaa caccacgtcg
     7801 ccctcggtga ccagccggtg tccaccgtag aacccgaacg agttggcccc ggtgacgtac
     7861 gcgccgccgt gcagccacac catgaccggc cgcttgcggt cgtcgggggc gggcgtgatc
     7921 acggtgaggt tgaggcaatc ctcgtcctgg tcgggcacct ccgccgggac gcccatgacg
     7981 ccgtccggcc gcaccggcgg ctgcgggctg accgggccgt ggcgggtcgc gtcgcggaca
     8041 ccggtccacg gctcggcggg ctcgggcggg gcgaaccggg gcgcgcgggc gaaggggatg
     8101 ccgcggaact cggccaggcc gtcggccgtg acgaatccgc gaagcttgcc gcgcccggcg
     8161 gccaccacgg tgtccacacc accactgtaa ccgcgggcag cgggcgatga tcgcggtgcg
     8221 gatttcgccg cgcgccactc aggacgggcg cgggtagagc cgccgggtcg ccgccatcca
     8281 gtgcgcttcg tccgccccca gcggcgggcg gccgagggcc tcccacaggt cggcgtagcg
     8341 gtcggccagg ccgtgccagc cgtcgtccgc cggggcgcgc agcgtccaac cgagcgcgtc
     8401 cagcggcagg tttcccttcg cgctgttgca cacccagcag gcggtgacga tgttgcccgg
     8461 atcgagcggg tcaccaccgc gcgtgaccgg gatgacgtgg tcgtgggtgg ccgagatcgt
     8521 ctcgatcgcc gggtgcacct caccggcctt ccagttccgg tggtacggga actcccgcgg
     8581 gtacgcggtc gacacgagac gcatgacggg cgtgaggacg gtcgggacgc cgcagtagcg
     8641 gcactggtag cggtcgcgct cgaagatccc ggcccgcacg cggatcgagg gcgtccgccg
     8701 ggggacgggc ggccggatgg gctcggcgat ggctcccatc ctcgcgtccg ccgcggcgcg
     8761 gtcctgccgg atgagcgccc ggaccacgtc gtgcagcaca tcggggtagc cggcggcgtt
     8821 cccgcccgtc gtcctcacca cgaacccctt cgttcctccg cccgggcccg gcgggcgtca
     8881 gtcgcggcgg tcctgttcgg ccaggaagcg ttcgaactcc gcgccgagct cctcggcggt
     8941 cggcatcgag ctttcgtcgg ccagcagcgt cttcttcccg tccatcgcct cgacgaacag
     9001 gtcgtactgc cgctccagcg cgtgcaccac gtcggccacc tcgtcggatt cggccacctg
     9061 ccgcgcgatc tcggcgtcgg tccggcggga ggccgcccgc agcgcctcgt ccggcagcga
     9121 caggcccgcc agccgcgtga tcgagcccag cacggtcagc gccgccgccg ggtagcggga
     9181 ctgcgccagg tagtgcggca cgtgcgcggc gaacccgacg gcgtcgtgcc cggcctcgcc
     9241 cagccggaac tcggtcaggt tcagcgcgct gcccggcacc tccagccggt tgagcaccgg
     9301 ctcgtagtcg ccgatcagct cgcgccgcgt cgcgtgcgcg gtcaccccga gcgggcgcgt
     9361 gtgcggcgcg cccatcggga tcccgtggaa cgacacggtc atccgcacgt cccaccgctc
     9421 cacgagcgtc cgcaccgcgg ctgcgtagcg ctcccacatc gcgtccggct ccggcccgct
     9481 cagcaacagg aacggcgtgc cggcctcgtc gtggaacagc cgcaccgcca gctcgggtgt
     9541 gtcgtagctc tcccagtggt cggtgtcgaa cgtcatcacc ggccgccgcg cgcggtagtc
     9601 gatcagccgg tccacatcga accgggccac cacccggttg tcccagttcg tcttgaggtg
     9661 ctcgctgacc agcgtccccg cctggccggc gtccatgaag ccgtcgagct ggtgcaacag
     9721 caccgccccg ctcaactccg ggagctccga gtccacctcg tagagatccg tcggatcgaa
     9781 caccacagcc tcctgcctgt tccgggcacc tctctcctcg acactcaacg tagcgagggc
     9841 ggagatccat tccgtcgaag ggcttagttc caccgggtta ctgcgccact cgggcgaaac
     9901 tggttaagaa cagtgttcag ggatgctagg ttggatctct ccgtcacggc cggtacaccg
     9961 agcgtgatca acgtcgccgc tggaccacga gggaccaccc atgaccgccg acctggccga
    10021 gcacgcgcac cacctgctgc gcgccatggt caccgatccg tacggggact tctccccgtc
    10081 ggtgtacgaa accgcgcgcc tcgtctcgct gctgcccgcg ctggccgggc acgccgaccg
    10141 cgtcgcgttc ctgctggggc agcaggcggc cgacggcggc tggggcgggc cggagggcta
    10201 cggcctgctc cccacgctga gcgccaccga agctctgctg accgagttcc gccgcaccgg
    10261 cgccccggcg gccgcggccg ccgccgaaca ggggctgcgg gcgctgttca cgcggtgggg
    10321 tccggacctg cgggtgcgcc tcccggacac ggtcgcggtc gagatcctgg tgccctccct
    10381 ggtgtccgag ctcaacgcgc acctggacgc gctgacggcc gacgacatcg tgctcgccgg
    10441 cggccgccgc ctgccgcacc ccgagggcac gcacccggcg ctactggagg agctgcgccg
    10501 gctcgccgag gccgggcagg cgctgccgga caagatcctg cactcgctgg aggcgctggg
    10561 accggccgcg cacggggccg gtttcgcccg tcccggcgag aacgggctgg gctgctcccc
    10621 cgccgccacc gcggcgtggc tcggcggcga cgtcgccgcc ggccgccccg gtgtgcggta
    10681 cctggagaac gtccaggcgc gtcacggcgg agcggtgccg gtcgccgcgc cgctgacggt
    10741 gttcgaacga tcctgggtgc tgtccacgtt cgccgacgcg ggcctggcgg tgaccgtccc
    10801 ggacgaggtg ctggacggcc tggccgcgga gatcggcccg cacggtctcg ccggcggcgc
    10861 cggcctgccg cccgacgccg acgacacctc caccgccctg tacgccctgg ccgcgcaggg
    10921 ccggccgcat ccgctggact gcctgcgcga gtaccacgtg gacggtcact tctgcaccta
    10981 cccggacgag cgcacgccgt cggtcaccac caacgcccac gtgctgcagg cgctgtgcgc
    11041 gaacggaccg tccgaagtgg ccggacgggt cgcgtcgtgg atcgtggacc agcagcaccc
    11101 ggacggcagc tggaccgaca agtggcacgc ctccccctac tacgcgaccg cgcggtgctt
    11161 cctcgcgctg gccggcagcg ggcgcggcgt gacggcccgc gaacgggcgc tgcggtggat
    11221 cgcgacgacg cagcgcccgg acggctcgtg gggtcgctgg cagggcacgt tcgaggaaac
    11281 cgcctacgcg gtccaggtcc tggcccgcgc cggggagccg tgggcggacg aggccgcggc
    11341 gcgcggctgc gcgttcctgc tgtcctggcc ggaggccgcg catcccccgc tgtggcacga
    11401 caaggacctc tacaccccgg gccggatcgt gcgcgccgag gggatcgccg cgctgcacct
    11461 ggcccgccgc cgtccgcgga tcgcggcgct gctgacgcgg ctcgagccgg cgccggccga
    11521 gcggacggcg tgaatgaacc gggtggaact cgcgctcgcc gccacacccc tgcgcttcct
    11581 cgacgcgcac gccgacgacc cggccgcgat gctggacgtg cgcaccggag aagcgccgaa
    11641 gatcctggtg tggcaccacg acgcgctcac ctcgctgttc cggcaggacg cgcacctgcg
    11701 gcacccgggc agccgctcgc tcgccccgct gctcggcccg aagtcgatgc tgtgggccga
    11761 cggcacgcgc cacgccgcgt accggaagct gctcggcgcg ccgctgcgcg gacggcgcct
    11821 gcgggattac cacggcctca tcgcgcaggc ggccgcggcg gcgatcgacg cgctcgacgc
    11881 gggcacggtg ttcggcctgg cggcgtggac gcggcggctg gcgctggaca tcgtcgcccg
    11941 gatcatcctg ggtgcggcgg atccggtgct gctgcgcgat gtcacggcgt ggctggacca
    12001 cgcgctgggg tcgcgccgcc gcacgctcgc gcaccggttc ctgcgcggcg gcctgcccgc
    12061 ctcgggcgcg gagctggacg ccaggctggt cgccgccgcg aagtcggatc ggcggaacct
    12121 ggtgtcaccg ctgctgaccg gaaacggccc gctcggcccg gtgccggacg acgagctgcg
    12181 cgaccaggtg gtgtcgctgc tgttcgccgg gcacgagacg accgcgtcgg cgaccgcgtg
    12241 gacgctgtac tggctcacgc gccgggcgga cctgcgcgag gccgtgctgt ccgaactcgc
    12301 cgccacgacc ggcgacggtt ccgatccggc ggaggtcccg gtgctgcagg cggtgatctc
    12361 cgaggcgctg cggctgcacc cgccggtaga ggtcgccggg aaccggacgc tgccggagcc
    12421 ggtggagctg ctcggccgga cactgcccgc cgggacggtg ctcacccccg cgatctacct
    12481 ggcgcaccac cggtccgagt acttcccgtc cccgcacagc ttcgatcccg gccgattcct
    12541 gggccgccgc ggcgtgcccg agggctacct gcccttcggc ggcggcaccc ggttctgcct
    12601 gggcagccag ctcgggcagc tggagatccg gatggtcacc gcggccctgc tgcgccgtcg
    12661 cgtgctgcgg tgcgtcaacc cgcgcgccgg ggtggcgaag ctgcgcgggc acgcgatggc
    12721 gccctcggcc cggctgcgcg tggaagtcgt ggcgtgccgg gactgacctg gtggcaggac
    12781 gtggttctcg tgcaccgcct gcacttcccg ctgccgctga gctatctggc ctacgcctgc
    12841 tggggcgctg cgttcgcgga tccgcggcac ctgctcggcg gaccggtgct gctcagcgtg
    12901 gcggccacgc tgctggtgct gctggccgcg ctggcgctga acaccgcggc cgatctgcgc
    12961 accgacgagc aggaccgtga caagaccgcc ctggcgggcg cggcgcggcg gatcggcagc
    13021 gggcggatct tcgcctgggc ggcggccgag gcggcagccg cgatcgcgct gggcgcggcg
    13081 gtggcggtgt ggctgggccg ctgggcggcg ctgctggtga tcacggcggc gctggccgcg
    13141 cacctggcgt acaacctgga gccggtgcgg ttgaagcggc gcgggttcgc cgggcccgcg
    13201 gtgttcgggg ccgggttcct cgcggtgccg gggctggcgt cgtacttcgc ggtgcggccg
    13261 gcgctggagc ggtcgatggt gccggtgctg gcggggctgt gcgtgctcgc gttcggccgc
    13321 acggcctggt tttccgcgcc ggaccacgcc gccgacgcgc gcagcggcgt gcgcaccccg
    13381 ggcgcgcggt acggtccacg gcggacgctg gtgatctcct gcggggtcgt ggtggccggg
    13441 ctggcggtgc tgggctgcgg gctgtggtgg cggtacggcc cgggctgggc ggtcgccggg
    13501 gtggtcgccg aaggcgcttt cctcaccggg atggtcgcgc tggccggccc ccgcggatcc
    13561 ttctcgcgca tgcgcaagct cgccacgccg gccgtgctgg ccggtgacct cacgctggtg
    13621 gcgatcccgc tcctggcgta accaccgcgg ccagcgcggc gatgtcgtcc gggctcacgc
    13681 ggcagcatcc gcccacgtac tcgaccccgg cggcgagcca gtcgcgcacc gcctccggcg
    13741 agaaccgcgc ctgcccggtc cagccgcggg tccgcgcgtc ccaggtctcc ccgctgttgg
    13801 gatagacgat caccggtttc ccgctcgcct cccgcgcgat ctccgcggcc acggcgacat
    13861 cccgcggatc gcagcagttc acgcccacag ccacgatctg gtcgttgccg cgcacgaccg
    13921 agaacgcctc ggtcaggggc tgcccggcgc gcgtgctctc gccctcgatc gtgtaggaca
    13981 gccacgccgg gacgcccagc ccctcgatgg cgagcaggat ggcttcggct tcgtccacat
    14041 cgggcaccgt ctcgcagccc agcaggtccg gcccggccgc ggcgaggatt tccgcgcggg
    14101 gccggtggaa cgcggtcagc tccgccacgg acagcccgta gtggccgcgg tactccgacc
    14161 cgtcggcgag cgtggcgccg tagggcccga tcgacgcggc gaccagctcg tcgccggtca
    14221 ggcgcgcctc ccgggcgagt tcgacgctca gctccagcag acgcaccgac tcgtcgcggt
    14281 ccagacccag ttcggcgaag ccgccgaggc tcgcctggta gctcgcggtg gtcgcgatcc
    14341 gcgcgccggc gcggaagaac gcgcggtgcg ccgcgacgat cgcgcccggg tcgtcggcga
    14401 gcagccgggc cgaccacagc tcgccggaca ggtcgtgccc gcgcgcctcc agctcggtgg
    14461 ccagcccacc gtccagcacg acagtcacgg gccggtgcgc aggaaggtca gctcgcgcca
    14521 ccacacgtcg gcgagcacgt ccagcacgag cgcgcggtcg tggccgacgc cgcggatcag
    14581 ccagtggtag caggcctgtt ccagctgcag caccagcaac agcgcgcggg tcagcccggc
    14641 ctgctcgtgc tcgccggtcc actgtgtcag gtacggcgcc agctcccgcg ccgcgtccac
    14701 accccactgg tagtgccgcg ccgcgacgcg cgggtcgtcg gcgaccgcct gcgtcagcac
    14761 gtcgatctcc accgcgtagc gcgtccagaa cgccagcacg tgctcgtcca gccaggtccg
    14821 cacgcggtcg cgggtcagct ccgggaagtg cgcgagcatc cggtagagcg cggcggtgtc
    14881 cggcaggatc cgttcgaaca gcgctgccgc gatgtcggcc ttgtcgcgga agtgcgcgta
    14941 gaaggtggcc cggctgccgt tggcggccgc cacgatgtcg gcgaccgtgg cggcgtggta
    15001 gccgagacgg gcgaagacct cgcgggcgca ctcgaggtaa cggtcgtgcg cctcccgcca
    15061 ctgctgctcg cggaacgtgt tccgggcagg cgtggaaatg ccggtcatca ccccatcgta
    15121 gtgcgccgtc cgggggacga cacctccgcg cgggcggttt cccctgccgc agcgcgggat
    15181 ccgcggcagg ggaaggtgga gcggcacccg gcgccgggga tcggcccggg acaaaggagt
    15241 caacccggcg acgagtgcct cgctctagcc tgaacgagcg aactcgtgac ggaaacgaac
    15301 caccgttgca ctttcggtgt acttaccgga ccccgatgtg gttaccctga tcgtgtggcc
    15361 gccgggacga accctccggg agccgcgacc gcccagcagt ggacggggcg ggaggcgcgg
    15421 ctgctgcggc acgccctccg cctgtccgtg cgggggttcg cggcctacct cggcgtcgcg
    15481 gcgcgcacgg tcgccaagtg ggaaagcggc ggcacttcga cggtgccgcg gccggacacc
    15541 caggccatcc tcgacaccgc gctggccagg gccgacgccg gcgcccgcac ccggttcgag
    15601 gtgctggtga cccaggcgca ggaggccggc cgcgcgccgg aaccggcccc gcgctacgac
    15661 tacgaggcct ggaccgacga cctggaccgc acggtggcgt gcctggggcg ccaggagttc
    15721 cggctcgcgc gcacgctgct ggaccgctgg ctggcccggt tcgagccgaa cagctccgac
    15781 cggcaaggca tgtacctcta cggccggtcg ctgcggctgc tcggcgaggt gcggcaggac
    15841 cagggcgcgc tgcgcggccc gctgtccgcc gagcacgtct accggcaggc gctgcgcgtg
    15901 ttcaccgaac tggagtcccc gcgccgcgtg gcccagctgg aactgcagct ggtcgtcatc
    15961 gacgagatgt ccgggcagct ggacgcggcc gccgcgcgct acgaaagcct caccgccgac
    16021 gagcggctca gcccgcacga ccgcacgcgc gcccggcttt gggtgggcac cgcgctgagc
    16081 aaacgcggcc tgcacgagac cgccacacac cacatcgtgc cggccatccg cgagttcgaa
    16141 gccctggagg agcccgcgga ctggtcgatc gcgcaccaga aactggcgct ggcccaccgc
    16201 ggcgcgggcg atctcaccgc ggccggccgg gccatcgacg tggcactgac caaccgggtc
    16261 gacgacaccc cgctgcagca ggtgcggctg gagaccgcgc acgcgcacat cctgctctcc
    16321 gacaccgcca ccgcggattc cgggctcgcc attctggacc ggaccgcccg catttccacc
    16381 cgctacgggc tcatgcacca attgcgcagc atcgacagca ttcgccggcg tttcgagtcc
    16441 cggtaagaaa cccatgcgga aagcactact cgacacggtg tgggccgacg ccgaactcgt
    16501 ctgggagttc caccggctgc gccaccgccc gaaaccgtgc tcggcggccg tggcactggg
    16561 ctgcaacgac ctcggtgtcg ccgcgcacgc ggccgaactc taccaccgcg ggctgttccc
    16621 ggtcgtggtg ttcagcggcg gcaacagccg cgagaccgcg cgcgccttcc cacgcggcga
    16681 gggcgtgcac taccgggagc gcgcgctgga actgggggtg cccgacgagg ccatcctcgt
    16741 cgagccgcac gccaccaaca ccggtgagaa catcacgctg tcacgggagg ttctcgccgc
    16801 cgcgggcatc gaggtgtcgt cgttgatgct ggtctcgatg ccctacatgg agcggcgggc
    16861 gttcgccacg acgcgcaagg tgtggcccga ggtcgagccg gtgtgcgcct cggccccggt
    16921 gtcgctgacc gagtacgcgc tgcggacgca gcacggcacc gaactgatcg acatgatcgt
    16981 gggcgatttc cagcgcctca tcgagtatcc ccgaaagggt ttcgcaattc cgcagaaaat
    17041 tcccccgatc gtgtattcgg cgtatcggag actggtggtc gccggattcc gcagccgcat
    17101 gctgtgattc catacggccc gtgcccgaga cgctttcctg cgccgtccat caaccgaatc
    17161 tcttcccccg gctgtccaca ctgggcaaac tggtccgggc cgacgtgtgg gtcgtgctcg
    17221 acgacgtcca gttcaacgcc cgcgactacc agcaccgcgc ccggctcgcc gcgccggccg
    17281 acccggaggc ccagcgctgg ctgaccgtgc cggtgcaccg cccccgcggc cgggacagcc
    17341 ggatcggcga actgctcctg gccgatccgg ccggcaccca ccgcacggtg tcccgcctgg
    17401 tgcggcagta ctacggccgc tgcgcacact ggccggagac cggcgaactg gtcgaggagg
    17461 tgctcgccgc gctggccctg aacgagcggc cggcggtcgt ggccgaggtg tcggtgcgcg
    17521 cgatgctgca ccggctcggc tggcgcggcg cggtggtgcg cagcagcgac ctgccctcgc
    17581 gggagggccg gtcgcagcgg ctggccgacc tcaccgccgc ggtcggcgcc ggcacctacc
    17641 tgtgcgggcc gggcggggcg aagtacctgt cggagggccc gttcctggag cgcggtctcc
    17701 aggtgcgcta cccgccgcca cccccgctga cccgcgagcg cgggatgcgc acggccagcg
    17761 cattgtgggc gttcgcgcag cgcggtgcgg ccggtgtccg cgacgcgctc gccgtggact
    17821 gcgtgcccgc gcgctgaccc ccaagagccg ttctacacaa ggtaaagacc attccggcaa
    17881 ccgggtcttc acggcggccc ggttaccgtc gcctcccgtg cgtctgtctc gtggtgtgcc
    17941 ccggttcctc gccttctgcg cggtcgcggg ggtgctcgtc gccggggtgg ccgcgcccgt
    18001 cgcgctcggc gcgggggtgc tgtcgaacca ggtcgccgac gccgtggacg ggctctccgc
    18061 cacactcgcc aacagcgagc agccgctggt gaccaccgtg accgaccggg acggcacccc
    18121 gatcgcgacg ctgttcgacc agtaccgcct gccggtcacc gccgggcaga tcgcgcccgc
    18181 gatgaaggcc gcgatcgtgt cgatcgagga ccggcgcttc tacgacgagg gcggcgtcga
    18241 cgtgaagggc atggtgcgcg ccgcgctgca cgactcctcc ggcggcagca cgcagggcgg
    18301 gtcgacgatc acccagcagt acgtcaagaa ctacctcatc aacgtcgtcg accgcaacga
    18361 cagggcggcg cagctggccg accaggccga cacgatcgcc cgcaagctgc gtgaggccaa
    18421 gatcgccgtc cagctcggac agacggtgtc caaggaggac atcctcaccg gctacctcga
    18481 cgtggtggag ttcaccggca acatctacgg cgtcggcgcc gccgcgcacg cgtacttcgg
    18541 caccacgccg gacaagctga cggtgccgca ggccgcgctg ctggccggga tggtgaacaa
    18601 ccccaacctc ttcaacccct acacccaccc ggaccaggcc ctgcagcgtc gcaacctggt
    18661 gatcgacgcg atggtcagca cgaagacgct caccgcggcc gacggggcca ccgcgaaggc
    18721 cgcgccgctc ggcgtcctgc ccgacgggcc ggacgtcccg tccagcacgt gcctgggcgc
    18781 cgcgccggac gccgggttct tctgccagta cgcggagagc tacctcatcc agtccgggtt
    18841 caccgccgac cagctggaga ccggcgggta cgtcatccgc accacgctgg acccgcgggt
    18901 gagccggatc gcgaaggccg ccgtggacgc gaacgtgccg accacgcagg acggcgtggc
    18961 gaacaccttc gcggtgatcc ggccgggcca gaccacccac gaggtgctcg cgatggtcgc
    19021 caaccgcgac tacggcaccg acccggcgcg gggcgagacg tcgaccaaca tcgtcgcggg
    19081 tgcgagcaac gtgttcggcg ccggatcgtc cttcaagatc ttcacctcgg ccgccgcgct
    19141 ggaaagcggc aaggcgggac tggacacgcc gctgcccaac caggccggcc agtgcttcgc
    19201 ccagcccggt gcgaacaagt acacgccgcc gtactgcgtg cagaacgacg gcgtgaacta
    19261 cccggacccg atctcgctgc gggacggcct ggccacctcg ccgaacgtcg ccttcgtcaa
    19321 cctggagcaa caggtcggga tgccggccgt gctggacatg gcgcggcggc tgggtctgcg
    19381 caacacgctg accacgaacg acgcgggcgc caagcccgac ccgtcgtcgc cgaacccgca
    19441 gtacagccag ccgcagtcgc agtacttcca ggacaagctg tcgttcacgc tgggcaacag
    19501 cccggtgagc ccactggaga tggcgaacgt gtcggcgacg ctgatgagcg gcggcacgtg
    19561 gtgcccgccg gacccgatcc tgtcggtcac cgaccggtac gggcacgacg tgccggtgcg
    19621 gcagcaggcg tgcgagcagg tggtgccgcc ggggctggcg gattcgctgc tgaacgggct
    19681 gagccaggac acggtgtcgg gcacgtcggc ggcggcggcc gcggcggcgg gctggcacca
    19741 cgcggacttc ggcaagaccg gcaccacgca gcagagcgag tcggtggcgt tcgtcggcgg
    19801 ggtcgacgac tacgccgtgt cgtccatggt cttcgccgac ggcccccacc cggccgagat
    19861 ctgccccggc acgccggtgc acctgggctc gtgcgggcac ggcgcgttcg gcggcacggt
    19921 ggccgcgccg ccgtacttcc acgcgatgaa ccagatcctg ggcggccgcc cggacacgcc
    19981 gatccccgcg gccgatccgg cgtacctgcg cgcccgcggg tagatgtcgc tggtcgcgcg
    20041 cgcaggcgat ggcgatctct cgcagatgtg cctcgccatc cccgcccgcg cgggtggctt
    20101 cccaggagtc agtcgctcaa cgagttgacg tggatcgggg cggcgtgtcg gcctgcgcgg
    20161 ccggtaccgc caattcggcg aaggcggcgg caccggacaa cgctacctcg tgaccgacag
    20221 cctggtgaca acctagccac gcaacgccgt cgtgtcgtaa cctccggtga gtgggcctcg
    20281 aggaggaaga gcccccggaa gccgccgggc tcggtccggg tgagctggtc gccgggcagt
    20341 acgaggtcga ccggtgcttc gcccgcggcg cgttcggctt cgtctacctc gcccgcgacc
    20401 ggaacctgca gggcaagcag gtggtgctca agggcctgac ccgcccgcac gacacggccg
    20461 cgatcaagct ggccgcgcac gagagccgcg tgctcaccgc gctcgagcac cccaacatcg
    20521 tccgcatcgt caacgtcgtc acccaccgcg gcctgcgcta cttggtgatg gaccacgtcg
    20581 acgggccgtc gctgcggagt gtgcgcgacg cgggcggcat gacgatcgcc gacgcgctcg
    20641 cgtgtgccgt cgacgtgctg ggcgcgctgg cctacctgca cggcaagggc ctgctgtact
    20701 gcgacatgaa gccggacaac gtgatccgca cgcgccggtc ggccaagctg atcgacttcg
    20761 gcgcgatccg ccgcaccggc gaccgggaga gcccgatcct cggcaccacg ccctacctgg
    20821 tcggccacac cgagatccgc gagcacgggc tgaccgagcg ggccgacatc cacgcggtcg
    20881 gggtcatgct cgacgagctg gtcgagtgcg gcgacgacga cccgggggcc gagtcgttcc
    20941 gccgcttggt cgcccgcgcg accgccgact acgaccggcg cttcgccgac gtgccggaga
    21001 tgctcaacca ggtgcgcggg gtgctgcgcg aggtgcggtg cctgaccgac ggcaagtcgc
    21061 ggccggcgcg gtcggcggtg ttcgccgaat ccgcggcgct gctggacgac gggctcagcc
    21121 tggccccgcc gctgaccacc tggaccggcg gcggcagcac gaccctggcc gacgggcggc
    21181 cgtccccggc ggacgtggcg accggcctgc ccgtgccgtt ccccgatccg gacgatccgc
    21241 gcacgccgct gctgcacacc gtgcgcgcgc cggacccgcg gcggttgctc accaagctcg
    21301 cgagcatccc cgggtcggtg gaggtggact tccaccgggc tcgtgcgcac ctggaggcag
    21361 gcaacctgac cgcggccggg cacagcctgc gctcggcgga gcggcagctg ggctggcggg
    21421 cgcaccacga ctggcgcacc agctggcacc gcggcctgct ggcgctggcc gagggccggg
    21481 tgcgcgaggc cgaggagctg ttcgacgagg tctaccggtc cacacccggt gag
//
