LOCUS       NZ_BNAU01000001        22094 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000001
VERSION     NZ_BNAU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1754180)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1314419
            Orig. end                         :: 1336513
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22094
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22094
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22094
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12094](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12094)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            637..1050
                     /locus_tag="IE290_RS06420"
                     /old_locus_tag="GCM10017786_13130"
     CDS             637..1050
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="IE290_RS06420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13130"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_191243508.1"
                     /transl_table=11
                     /translation="MTELDDCGPEVAATFAEFATAMADHGFGFLRQRRDAGYRDGPILV
                     TQAGRRVVGAIGPLTIMPDRSGREMSLPQYFGVLPEHRGHGHGRALWRAVERWSVHHRA
                     HYQLLQARAGGASDRLFQSEGLRPLGYVSTVSA"
     gene            1047..1886
                     /locus_tag="IE290_RS06425"
                     /old_locus_tag="GCM10017786_13140"
     CDS             1047..1886
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS06425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017786_13140"
                     /product="phosphotransferase"
                     /protein_id="WP_191243509.1"
                     /transl_table=11
                     /translation="MSPTPNPSAAHAMTPATLRTQWQQLPAALRAAIEQHTGRVHRAET
                     ISAGLNATFTARLHTETGLIFAKGTPSTRAAGQRREACINPYAQPIAPRLHWHIDIAGW
                     HILGFEHLDGHPAELSPGSDDLPDVTRMLTQLTELKVPTTGCRRIEDRWADAAKQADTD
                     PALLAGNHLLHTDLNPHNILITKRGARLVDWSWPTLGAPWIDTACTALWLIAEGHTPAD
                     AERWASAHPAWSTAQSAAIDTFTATSAALWGQIASNEPRPWKLRVRDAAATWAQHRA"
     gene            complement(1993..2223)
                     /locus_tag="IE290_RS06430"
                     /old_locus_tag="GCM10017786_13150"
     CDS             complement(1993..2223)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155815.1"
                     /locus_tag="IE290_RS06430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13150"
                     /product="DUF2188 domain-containing protein"
                     /protein_id="WP_191243510.1"
                     /transl_table=11
                     /translation="MAKGDVETYYEDGQWKNKIQGNQRASNTANTKAEAQAEGRRMAVE
                     RAVEHVVKRQDGTIGEKNTYPRSRDQHPPKG"
     gene            complement(2484..5303)
                     /locus_tag="IE290_RS06435"
                     /old_locus_tag="GCM10017786_13160"
     CDS             complement(2484..5303)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017539.5"
                     /locus_tag="IE290_RS06435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13160"
                     /product="NACHT domain-containing NTPase"
                     /protein_id="WP_191243511.1"
                     /transl_table=11
                     /translation="MTEPTSLALIVAQAAVKAAAGSATTASLPALRKLLKKVRLDPKIL
                     RGFTAWQEAKIDKAQEEKIVKFVLSREFQGLLELVAYLEYHTSDRWLEERKKLRETFAD
                     EIARRVTLDDHTLHTVTESLWSLAHDSVRLEVDRVRKSGRSRRESNMYVQSLLAAHLFP
                     DDTTLQRAVESRSTLASHYTDVTHARALAAQVREETHRSHSTIQMPHSRENFRPPVHRL
                     YVHRKMLGAGSGAADRFSTEIPDHQVHEYERRVVVLGNPGAGKSTYIRYLTHWLSSDES
                     GREPVTPFLVELKNFGKGGDDLVQMIGSRLRLLLQTEVDLKHIRTILTLGSATVVFDAL
                     DEAGDLTDRREAVEAIERFCRRYPLVQVVVTSRRQGYGSAQLDPSLFAAYILPDFNPAQ
                     IRNYVDSWFRFVAGPDAILPSARATAFLRDSEHIHELRSNPLMLSLLCLLYEYEGWIPE
                     NRLQVYKECANLMFVRWDRARRVNAKETTLGSTHIWFLFQELGYWFFTKDVTTAPTERA
                     VHQVIERFLARELQDHVTADTSIEATDFLEFCAGRAWLLTRVGSTAKGERLFDFTHRTF
                     MEYFAAEYLTRHSDSIDEFVATIWQLIQTGASYVVPQIAIQQFDINVANGLNRTMLGLL
                     KLGSEAPGTLHPFVLDTLHYVQPSASTVETILLAALKHIAAHRDDDLATQLAQLPSRFS
                     AVLEDLSLRELAKATASEDFAAAQFRGAVGFVIAANIPLPPDTSLRPFYSGHRGSRVLA
                     PWRHLARSHPSTVYELYRGKVLDAEEFLAVAGRPALVRAPEFLLLDLLRAGEPADWLLD
                     TIASHPDSLLPLPSPLVEQALPVLTDLAQARPTNLDDTAARRAGWYALFAAFSCAAFEQ
                     GRDWLPLFRAVITKLGHEAELAGMSRVQLGGLARVVGNDAGLRTRWADKLGEWQHGLIS
                     FGTADNQGR"
     misc_feature    complement(3198..3200)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5591..6247
                     /locus_tag="IE290_RS06440"
                     /old_locus_tag="GCM10017786_13170"
     CDS             5591..6247
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS06440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017786_13170"
                     /product="hypothetical protein"
                     /protein_id="WP_191243512.1"
                     /transl_table=11
                     /translation="MTTLLPSASSSPHAERRLNVFGLSTELVHSAFRPGLSRATNRTSK
                     ALGSTPGTDLYHDTMESLHLQLAESGWRLVYVDHQPRLLHPEGLLSFTVASATNVADPD
                     RRRQPRTRRKGKATRDSLTADRTGTSSLFEGLETNQDQELLAAAEATPLWLLLHERTDR
                     GLRLELSRPSDMTEGGIVTKWEDRILIAFLDLDGDLSIFDNPNDSGDIDVRVEPR"
     gene            6267..7298
                     /locus_tag="IE290_RS06445"
                     /old_locus_tag="GCM10017786_13180"
     CDS             6267..7298
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.5"
                     /locus_tag="IE290_RS06445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13180"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_191243513.1"
                     /transl_table=11
                     /translation="MFNPSRLRLARQRLALTLTKLAQLSGVSLRSLTNYETGKLAPNEE
                     NLRKLARTLEVPTAFFERDAVDTIPVEAASFRKLSKTTATRRDAVLAGASLVVEFFGVV
                     EAKFKLPAPDIPTLDKFPPEQAAELLRRRWNLGDKPISNVVHLLESRGVRVAALRHEFD
                     DIDAFCFLRDTTPYVFLNTAKTGERQRFDAAHELAHLVLHGEQDMEPGTSKEREKEANR
                     FAASFLMPASAVLDQSMRNASLDRILAARSYWKVSAMAMTHRLHELHLLSDWQYRSTCA
                     ALSEQGYRTTEPGGIVPETSQLLRKVMFGTMGRVSVHDAAAHLDLSQDEVRQFIRNLVP
                     TVA"
     gene            8107..8655
                     /locus_tag="IE290_RS06450"
                     /old_locus_tag="GCM10017786_13190"
     CDS             8107..8655
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS06450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017786_13190"
                     /product="hypothetical protein"
                     /protein_id="WP_191243514.1"
                     /transl_table=11
                     /translation="MMIDYDVSDDWSEDAPDWLKSLVSSLDRNHGASTVLPLTVIVEEI
                     AEWIELASGTDAWKKTANRDSLQWDLDKSVGAISSSLRAHIPGPLAAFQTAFGNLISSS
                     SAVLSQPPGTRVDAVWTEALSTARNLLNALDSDQAVRASWDDLVAKAQDRTLARREYHP
                     IVELLFEQLQRRGLSVSTS"
     gene            complement(9050..9415)
                     /locus_tag="IE290_RS06455"
     CDS             complement(9050..9415)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS06455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_191243515.1"
                     /transl_table=11
                     /translation="MEQKLSRRASAMVGDDIAAWLRNTPVELFSGVFPELVARYDLKVS
                     GVSDLDIRRRRGVVCGRLSGTILGGFLSISHLRRRFRSSVSHLRASNCFSRAFSCAGQL
                     GILDGVQPGERHPLAPA"
     gene            9449..9988
                     /locus_tag="IE290_RS06460"
                     /old_locus_tag="GCM10017786_13200"
     CDS             9449..9988
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018333391.1"
                     /locus_tag="IE290_RS06460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13200"
                     /product="manganese efflux pump"
                     /protein_id="WP_191243516.1"
                     /transl_table=11
                     /translation="MIWEVLVLGFVLSLDNFRVSIALGTVPFGLKRAVQVALVFGLWDT
                     VMPLVGLLIGRRIGDAFGVVADVVGAAALGGYGLYLLASALRNPEPEELDHPWALFGIP
                     LALSLDNLFAGASLGILGLSPWFSAAVFGVMTAVLSLVGLQLGRAAARLIRIRSDLLSG
                     LTLIVAAATLPVLFGG"
     gene            complement(10001..11098)
                     /gene="pqqE"
                     /locus_tag="IE290_RS06465"
                     /old_locus_tag="GCM10017786_13210"
     CDS             complement(10001..11098)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672942.1"
                     /locus_tag="IE290_RS06465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13210"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_191243517.1"
                     /sec_met_domain="PF04055 (E-value: 5e-25, bitscore: 85.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.1e-06, bitscore: 24.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 7e-10, bitscore: 36.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.3e-09, bitscore:
                     32.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSPFGLLAELTYRCPLACAYCSNPVNLAGYSGELTTDEWRRVLA
                     EARDLGVLQCHLSGGEPLLRRDLVDLVAHAHGLGLYTNLVTSAFGLSRPRAEQLRAAGL
                     DHVQISVQADEPAVSDRIAGTPSFRRKIEAMGVVKELGWPLTVNVVLHRHNIDRVAGVL
                     GLAEEVGADRVELANTQYYGWAWRNRDALLPSRAQLAAAEVVVRAARERLRDRMDVIYV
                     LPDYYSRYPKPCMGGWASRQLTVTPNGDVLPCPAAQSLPLPRASVREESLERIWAGSPV
                     MSAFRGTDWMPEPCRSCARRELDFGGCRCQAFLLTGDAARTDPVCHLSPDHHLVARAVE
                     AANAASPGGDRPLIPRPHRVRRVER"
     gene            complement(11091..11384)
                     /gene="pqqD"
                     /locus_tag="IE290_RS06470"
                     /old_locus_tag="GCM10017786_13220"
     CDS             complement(11091..11384)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010696864.1"
                     /locus_tag="IE290_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13220"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_191243518.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.3e-19, bitscore:
                     66.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.3e-12, bitscore: 43.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPATRPDLSAVDRPRLARHVRLSFCRTRQRPILLLPETVVVLNG
                     SGADILGLCDGRHTVAEIVAELGARYRSVPGDEVRRFLTRLVARRWVEAGDG"
     aSDomain        complement(11106..11354)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE290_RS06470_PqqD_RRE.1"
                     /evalue="2.20E-21"
                     /identifier="RREFam006.1"
                     /label="IE290_RS06470"
                     /locus_tag="IE290_RS06470"
                     /protein_end="93"
                     /protein_start="10"
                     /score="66.4"
                     /tool="antismash"
                     /translation="AVDRPRLARHVRLSFCRTRQRPILLLPETVVVLNGSGADILGLCD
                     GRHTVAEIVAELGARYRSVPGDEVRRFLTRLVARRWVE"
     gene            complement(11390..12094)
                     /gene="pqqC"
                     /locus_tag="IE290_RS06475"
                     /old_locus_tag="GCM10017786_13230"
     CDS             complement(11390..12094)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010241625.1"
                     /locus_tag="IE290_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13230"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_191243519.1"
                     /sec_met_domain="TIGR02111 (E-value: 4.5e-96, bitscore:
                     317.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATSGTTRTDADGFVEALRAHSRRYHDRHPFHVRMNAGRLSRRQ
                     IQGWVANRFYYQENIPRKDAAILANCPDLEVRRRWIRRVVNHDGRHPGEGGVEAWLRLA
                     EAAGLTREEVQDHRHLVPGVRFAVDAYVDFARTRPWVEAVASSLTELFAPDLMAERLAA
                     FERWYSWIEPAGLAYFRARLEEAPRDCEHALEVVTAYCRSPESRARAVDALSFKCDVLW
                     SLMDAIDQAYPE"
     gene            complement(12098..13057)
                     /gene="pqqB"
                     /locus_tag="IE290_RS06480"
                     /old_locus_tag="GCM10017786_13240"
     CDS             complement(12098..13057)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672939.1"
                     /locus_tag="IE290_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13240"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_229874247.1"
                     /transl_table=11
                     /translation="MEWRWTAGPAPSGGPAGEETEGVVLLRVLGSAAGGGSPQWNCGCP
                     VCTAVRSGAGPARTQSSVAVSADRRRWFLINASPDVRTQIEAFPALHPREDRTTPLEAV
                     LLTDAELDHTLGLLVLREARAGLSLYTTPAVHKTLRDGSRLLPALERYCPVQWRAVVPG
                     VGMSLDGGLSCRAFDVPTTKRSRFGPGEDHGRVVGYRLTDERSGGTLVYLPGVQALTRE
                     LAAEMQGCQCLLIDGTCWRDDELVRLGLAGKTSREMGHLPIDGPDGSLALLPALGVGRT
                     IFVHMNNTNPILLEDSPERRVVEGSGMEVARDGLEVEV"
     gene            complement(13064..13159)
                     /gene="pqqA"
                     /locus_tag="IE290_RS06485"
                     /old_locus_tag="GCM10017786_13250"
     CDS             complement(13064..13159)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942740.1"
                     /locus_tag="IE290_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13250"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_027935205.1"
                     /transl_table=11
                     /translation="MESELVVWETPEFEEIGVAPEVTMYVAQMED"
     gene            complement(13206..14906)
                     /locus_tag="IE290_RS06490"
                     /old_locus_tag="GCM10017786_13260"
     CDS             complement(13206..14906)
                     /EC_number="1.1.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942739.1"
                     /locus_tag="IE290_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13260"
                     /product="PQQ-dependent dehydrogenase, methanol/ethanol
                     family"
                     /protein_id="WP_027935204.1"
                     /transl_table=11
                     /translation="MTVEYVDAGEAIDQGRLSGKVAGGEVAPPVVRDVGYERILNARSE
                     PQNWLTYYGAYNGQRYSPLDQINTENVKRLGPAWVFQAGTTGLIAGASTYSFEAAPIVV
                     DGVMFLAGWDGWVWALDAKTGVEIWRYKHAVPFDVSLCCGNVNRGVAVAAGKVFFVTAN
                     AHVLALDATTGKRVWDQTYGDVRAGESATVAPLIVKNKVIVGSSGGEFGVRGHLDAFDL
                     ETGEHQWRCYTVPKPGEPGSDTWPADGEAWARGGANCWITSTFDPETNLLYVGTGNPAP
                     DFDGGVREGDNLYTDSIIAVDVDSGQIRWHHQCTPHDVWDYDSIGECILFESEGRKLLG
                     HFDKNGYFFVLDRTDGALVQVTPFVDRITWGAITRDGKVTAKVYPDEEGVPVHFYPGPA
                     GAKEWTHAAYSPRTELFYVPVQDVGATATRRRREFKESIPYWGAGVQVDIEDMTGSISA
                     FDANGEEKWRWRNELPMCASVLVTGGDLVFAGEPSGEFNALDARTGELLWQFQCGSGHH
                     SNPTTYMVDGRQYVAVPVGWGAWSEGFLPGMLGAGHGSALIVFALPETS"
     gene            complement(14922..15383)
                     /locus_tag="IE290_RS06495"
                     /old_locus_tag="GCM10017786_13270"
     CDS             complement(14922..15383)
                     /GO_process="GO:1901661 - quinone metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242305.1"
                     /locus_tag="IE290_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13270"
                     /product="MSMEG_3727 family PQQ-associated protein"
                     /protein_id="WP_191243520.1"
                     /transl_table=11
                     /translation="MTTAQERVDLLNELGLDAQNKAALGQVLGTGSIGKATERADGRME
                     ATIRIRPDEISWDPSILVMPHGGDIELELVNDDLNTHCALLPSNGDRKFIWLVNHSKGK
                     ATLNLDGPGYYWFSSPTGNDEGRGLTGAIVVLGDVPPEARLDRPDQPRP"
     misc_feature    15407..15422
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.94"
                     /tool="antismash"
     misc_feature    complement(15457..15471)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.3"
                     /tool="antismash"
     misc_feature    15464..15479
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.2"
                     /tool="antismash"
     gene            complement(15599..17830)
                     /gene="katG"
                     /locus_tag="IE290_RS06500"
                     /old_locus_tag="GCM10017786_13280"
     CDS             complement(15599..17830)
                     /EC_number="1.11.1.21"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="katG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013677548.1"
                     /locus_tag="IE290_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13280"
                     /product="catalase/peroxidase HPI"
                     /protein_id="WP_191243521.1"
                     /transl_table=11
                     /translation="MAESADAPAAPATAGGGLGLSVPSEPRTHRAAGARLRDWWPDRLD
                     LTGLRRNHSMAEDFDYAAEFRTLDLDALARDVDAVLTTSQEWWPADFGHYGPLVIRMVW
                     HAAGTYRIDDGRGGPAAGLQRFAPVNSWPDNRNLDKARRLLWPVKQKYGRKVSWADLMI
                     FAGNRALETMGFTTFGFAGGRADVWAPDEDVDWGPEPVWLGDGRHRGVRELERPLAADQ
                     MGLIYVNPEGPNTVPDPLTSARDIRETFRRMGMNDEETVALIAGGHTFGKTHGAADPER
                     HLGPEPEGAPIEEQGLGWKSSYGTGKGADTITSGLEGTWTPTPTRWDNSFFETLFGYAW
                     DLVLSPAGLWQWIPGDGGGAGTVPDAHDPSKRHAPTVLTTDLALRFDPVYERISRRFLD
                     NPDQLADAFARVWFKLTHLDMGPIQRYLGPLVPRERLLWQDPIPAVDHELVDADDVAAL
                     KATILGSGLPVARLVSTAWASASTFRVSDKRGGANGARIRLEPQRGWQVNDPDTLAQVL
                     RRYERIQESFDSTETRGKRISLADLIVLGGCAAVEQAAKAAGFDVEVPFTPGRMDASQE
                     WTDVESFAALEPASDGFRNYRGKGSRLPSEHLLVDRAKLLNLTALEMTALVGGLRVLDA
                     NSGQSPLGVFTSAPGTLTNDFFVNLLDPGIEWTAAAGSVPGAETFVGRDRATGEVRWTG
                     SRVDLVFGSNAELRALAEIYASDDAGERFVRDFVAAWDKVMNLDRYDLA"
     gene            complement(17855..19249)
                     /locus_tag="IE290_RS06505"
                     /old_locus_tag="GCM10017786_13290"
     CDS             complement(17855..19249)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672934.1"
                     /locus_tag="IE290_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13290"
                     /product="DNA-binding protein"
                     /protein_id="WP_191243522.1"
                     /transl_table=11
                     /translation="MRDAHRHEPVAGNPGSGTVLAAWERFVRGEDQVPGVRPVVAISWY
                     RCRDQYRVDPHLREVPVAVAKPDPAPEHDVVFAELGFRAASVAHEVGNLGGVVTVTDAT
                     GRILAEWGDQATLARATDANLAPWFCWSECAAGTNGMGTALEAHGPVLIRGAEHWCQAF
                     HDWFCEGVAVRDVVTREPIAVLNISCWRSQLPASAGSWLANAVTRTQRMLTRRARDSGA
                     ELVAAFSQARARSTAGLAALDNAGKVVIADETAGVLMGVPAATPAVDPTLRWRPGLPEL
                     IGAVRYASRQAARNPDWVGSTQIFTRLADEPTSISIRPVFTSGHLIGNLVSFGDPDGAP
                     VPRADGAAQPRPRPRRVVATRDNRMVLLRLPEVSFAESEGNDVWLCTDQGRLRAASAGL
                     DKFDGELADAGFLRVHRRYVVNLSRVREVERGVKGELSLIMDDGGNTMVPVSRRNVPAV
                     RRALDI"
     gene            complement(19780..20346)
                     /locus_tag="IE290_RS37745"
                     /old_locus_tag="GCM10017786_13300"
     CDS             complement(19780..20346)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="IE290_RS37745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13300"
                     /product="MFS transporter"
                     /protein_id="WP_229874248.1"
                     /transl_table=11
                     /translation="MTSGVRKLPAGFGRLWTARTVSSPGDGVSHAALPLLGLTLTRDPM
                     ALAVVTAAGMVPWLIFGVLGGALVDRWDRRRTMWVVDAARAVLLAVVAFLPGLGGLFFD
                     TSATAYLPDLLGRDPARLERAKARLRGAQTHVRLRGPAGSVLPALGRAVPLRLRPARSP
                     RRPPEACSPRASPPGSAGGSAPAPH"
     gene            complement(20343..21149)
                     /locus_tag="IE290_RS37750"
                     /old_locus_tag="GCM10017786_13310"
     CDS             complement(20343..21149)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005438561.1"
                     /locus_tag="IE290_RS37750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_13310"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_373300398.1"
                     /transl_table=11
                     /translation="MGADTWTALGVSGMGEVDEATFSGLAERHRRELHVHCYRMLGSFE
                     DAEDTVQETFLRAWRRRETFEGRSTFRAWLYRIATNACLDLLAKCGPEPAAGGEVPWLQ
                     PYPDRLLDELPAGGAAADDRRPAHHRRSDHGDHHLPRRPVPAAGTAGAPAGGRHGVARP
                     AAHNRTVGKPLAARSIVLSDPGAGGPGVLMRHAVADLEASPVDGERHVRMAHLRLTDEQ
                     FAVLGARLHALADEYRELSDPSLPDASLVFALFHPAMGERADGDAQ"
ORIGIN
        1 gggcggtgag gggctgctcg ccgtgcaggt cgtgccaggc cagcaggaac gctcgccatt
       61 cggcggcgtc gtcatcgagt tcgcgggcgt gctcggcgtt gcccaggaag ttctcgatgc
      121 cgtggtgggc gaggaacccg ccgaggtgct gggcccagcg ggtgaactgc cgcatctgcg
      181 ggccgactgg atgaggcgag tgctcaccgt cccgtacatc ccggtcctgg gagcgacaca
      241 ccccgacctg tgcacgacgg agatgttcgt cgaggtgttc gctgaggtgc tgaccgccag
      301 ccgagccggc gtcgccctcc cgttagacaa ggaccggcgc tggtcaccga cgaaggcgga
      361 catcgtgctg accgacgaga tcgttcaccg cccggaccac acgatcatcc cggtcctcag
      421 ccagcgcggc ggcggcacgg taagacctac ttctacggcg actcccccga cctcgacgcg
      481 ctacaggcgg cgacacgccg cagctgcatc acccacgcag ccgcacacgg gcgcgtcatc
      541 tggttcagca ccagccccac cggccaagcg aaccacaccc gcgtactcct caaagacttc
      601 aaccacccaa cccccgaacc ttcaacagga ccggcggtga ccgaactgga cgactgcggc
      661 cccgaggttg ccgccacctt cgctgagttc gccacggcga tggctgacca cggcttcggc
      721 ttcctgcgcc agcggcgcga cgccggttac cgggatgggc cgatcctcgt cacccaagct
      781 ggccggcgcg tcgtcggcgc gatcgggccg ctgacgatca tgccggaccg gtccggccga
      841 gagatgtcgc tgccacagta cttcggcgtc ctgcccgaac atcgcggcca cggacacggg
      901 cgcgcacttt ggcgcgctgt cgagcgatgg agcgtgcacc accgcgccca ctaccaactg
      961 ctccaagccc gcgctggagg agcatccgac cgtctattcc agtccgaagg actccgtccg
     1021 ctcggctacg tcagcaccgt ttccgcatga gtcccacacc gaacccgtcc gctgcccacg
     1081 cgatgacccc agccaccctg cgcacccagt ggcagcagct gccggcggcc ctccgcgccg
     1141 cgatcgagca acacaccggc cgggtacacc gcgccgaaac gatcagcgca ggcctcaacg
     1201 ccaccttcac cgcccgcctg cacaccgaaa ccggcctcat cttcgccaaa ggcacaccca
     1261 gcaccagggc tgccggacaa cgccgagaag cctgtatcaa cccctacgcc cagcccatcg
     1321 caccgcgcct gcactggcac atcgacatag ccgggtggca catcctcggc ttcgaacacc
     1381 tcgacggcca ccccgccgaa ctctcccccg gctcggacga cctccccgac gtcacccgga
     1441 tgctcactca actcaccgaa ctgaaggtcc ccacgaccgg atgccgacgc atcgaagacc
     1501 gctgggccga cgccgccaaa caggccgaca ccgatccagc actgctcgcc ggcaaccacc
     1561 tactgcacac cgacctcaac ccccacaaca tcctcatcac gaagcgaggc gcgcggctcg
     1621 tcgactggtc gtggcccacc ctcggcgctc cctggatcga caccgcctgc accgcactct
     1681 ggctcatcgc cgaaggccac acgccggcgg acgcggagcg ttgggcatcc gcccaccccg
     1741 cctggtcgac agcgcagtca gcggcgatcg acacattcac cgcgaccagc gccgcactct
     1801 ggggtcagat cgcctccaat gaaccgcgcc cctggaagct ccgggtacgc gacgccgcag
     1861 caacatgggc acagcaccgt gcgtgaggcg aggccgacgt cataccctgc gcaccaagcc
     1921 caccggcgag taatgacgcg tgcagggcag cggaaatatg acggaggtag cttgtggtag
     1981 cgaggtcttc aatcagccct tcggcgggtg ctggtcacga ctccgcggat aagtgttctt
     2041 ctcgccgatg gtgccgtcct gccgcttgac cacgtgctcg acagctcgtt caacggccat
     2101 tcgtcgacct tccgcctgcg cctcggcctt ggtgttcgca gtattcgacg cccgctggtt
     2161 gccctggatc ttgttcttcc actggccatc ttcgtagtac gtctcaacgt cacccttggc
     2221 cacggctcac tccttcgctc gcttcacacc tcagcgtcga cgctgccacc actaagagca
     2281 agaagacacg ccagagagcg gatcaccact gcgggcctac cggtctttcc ggttcaagtc
     2341 cgacgctcat ctcgctcggt cctcttgact tcaggccgag gcgcccgaga cggcgcagca
     2401 gctctgacat cggtaggtcg ctcaactgct gcgtgaacgg gtgaaagccg ccgaaccgcc
     2461 gcccgcaacc ttgggtgggc cggttaccgg ccctggttgt ccgcagtgcc gaagctgatg
     2521 aggccgtgct gccactcacc gagcttgtct gcccaacggg tgcgtagacc tgcgtcgttg
     2581 ccgacgacgc gcgcgaggcc gccgagttgg acacgcgaca tgccggcgag ctcggcttcg
     2641 tgaccgagct tggtgatgac cgcccggaag agcggcagcc aatcccggcc ctgttcgaag
     2701 gccgcacagc tgaaggcggc gaagagcgcg taccaaccgg cacgccgcgc cgctgtgtcg
     2761 tcgaggttcg tgggacgtgc ctgcgcgagg tcggtcagca ccggcagcgc ctgctcgacc
     2821 aagggggacg gcagcggcag gaggctgtcg ggatgggagg cgatcgtgtc caagagccag
     2881 tcagccggct ctccggcgcg cagcaggtca aggaggagaa actccggcgc ccggaccagc
     2941 gcgggccggc cggccaccgc caggaattcc tccgcgtcga gaaccttccc ccgatacagc
     3001 tcgtaaaccg tgcttgggtg cgagcgggcc aggtgccgcc acggcgccag gacacgggat
     3061 ccgcgatgac ctgagtagaa cggccgcaaa ctcgtatcgg ggggtagtgg gatgttggcc
     3121 gcgatgacga atcccaccgc tccgcggaac tgcgcggcag cgaagtcttc ggaggcggtg
     3181 gctttggcga gctcccgtaa ggacaggtcc tcgagaacgg ccgagaaccg ggatggcagc
     3241 tgagccagct gagtggccag gtcgtcgtcg cggtgggcgg cgatgtgctt gagggccgcc
     3301 agtagaatgg tctcgaccgt ggacgccgac ggctggacgt agtgcagggt gtccaggacg
     3361 aacggatgca gcgttcccgg cgcttctgag ccgagcttga ggagaccgag cattgtgcgg
     3421 ttcagtccgt tcgccacgtt gatgtcgaac tgctggatcg cgatctgggg taccacgtag
     3481 ctggcgccag tctggatgag ctgccagatc gtcgcaacga attcgtcgat gctgtcgctg
     3541 tgccgggtga ggtactcggc cgcgaagtac tccatgaacg tccggtgcgt gaagtcgaag
     3601 agccgttccc ccttcgcggt actgcccact cgggtgagca gccaggcccg gccggcgcag
     3661 aactccagga agtcggtggc ctcgatcgag gtgtccgctg tgacgtgatc ctggagctcg
     3721 cgcgcgagga atctctcgat gacttggtgc acggcccgtt ccgtcggcgc agtcgtcaca
     3781 tccttcgtga agaaccagta accgagttcc tgaaagagga accagatgtg tgtggacccc
     3841 agcgtggttt ccttggcgtt cacccgccgc gcccggtccc agcgcacgaa catcaggttc
     3901 gcgcactcct tgtacacctg cagccggttt tccgggatcc agccttcgta ttcgtagagc
     3961 aggcagagaa gcgacagcat cagtgggttg gaccggagct cgtggatgtg ctcgctgtcc
     4021 cgaaggaacg cggtggcacg tgccgacggg aggatggcat ccgggccggc gacgaaccgg
     4081 aaccagctgt cgacgtagtt gcggatctgc gcgggattga agtcaggaag gatgtaggcg
     4141 gcgaagaggc tcggatcaag ctgggcgctg ccgtagccct gacgcctgct ggtcaccacg
     4201 acctggacga gcggatatcg cctgcagaag cgctcgatcg cctccaccgc ctcccggcgg
     4261 tcggtgaggt ctcccgcctc gtcgagagcg tcaaacacca ccgtggcact gccgagggtg
     4321 agaatggttc gaatgtgctt caggtcgacc tcggtctgca gcaggagccg caggcggctg
     4381 ccgatcatct gcaccaggtc gtccccgccc ttgccgaagt tcttcaactc caccaagaac
     4441 ggcgtcaccg gctcccgacc actctcgtcc gagctgagcc aatgggtcag gtagcggatg
     4501 taggtagact tccccgcacc agggttgccg agcacgacca cccgccgttc gtactcgtga
     4561 acctggtgat cggggatctc cgtcgaaaac ctgtcggcgg cacccgaacc ggccccgagc
     4621 atcttccggt ggacgtacag ccggtggacc ggagggcgaa agttctcgcg cgaatgcggc
     4681 atctggatcg tcgagtgcga acgatgggtc tcttcccgga cttgcgcggc gagcgccctc
     4741 gcgtgcgtca cgtcggtgta atgcgacgcg agggtcgacc ggctctcgac tgcccgctgg
     4801 agggtggtgt cgtcgggaaa caggtgcgcg gcgagcagcg attgaacgta catgttgctc
     4861 tcgcgccggg agcgaccgga cttccgtacc cggtcgacct ccagacgaac cgagtcgtgc
     4921 gcgagtgacc acaggctttc ggtcacagtg tgcagcgtgt ggtcgtccaa ggtcacccgg
     4981 cgcgcgatct cgtccgcgaa ggtctcccgc agcttcttcc gctcttcgag ccacctgtcc
     5041 gaggtgtggt attcaaggta ggcgacgagc tcaagcaagc cctggaactc ccgactcaag
     5101 acgaacttga caatcttctc ttcttgagcc ttgtcgatct tggcttcctg ccacgcggtg
     5161 aacccgcgaa ggatcttggg gtcgaggcga accttcttga ggagtttgcg cagcgcgggg
     5221 agggacgcgg tcgtcgcgct gcccgcggcc gccttgaccg ctgcctgtgc cacgatcaag
     5281 gcgaggctgg tcggctcggt cacctgcgcg ctccggatgg cctggacaac aggacaaccg
     5341 tcagtatcgc cgaagaggtc cagctcgtta cggactgtgc tggccattca cccgagaaac
     5401 acaccgcttg acacgaactg ccctaaccgg caacccgtct gctgaccaca tcctctgacg
     5461 gcacctcctc ctgccgaccc tgcccggcac cgggcgtgtc cgccggcgtt gctgcctcta
     5521 tccacggcgt gttgcgcgaa atccgcccac gattgcggta gcgtctcgcg catcttctgg
     5581 aaggagtgcc gtgacgacct tgctgccctc agcttcgtcc agcccgcacg ccgagcgtcg
     5641 gctcaacgtg ttcggcctgt cgacggaact cgttcacagc gccttcaggc ccggcctgtc
     5701 ccgtgccacc aaccggacat cgaaagcgct gggatcgacg ccgggcaccg acctctacca
     5761 cgacacgatg gagagcctcc acttgcagct ggcggagagc ggttggcggc tggtctacgt
     5821 cgaccaccaa ccccggctcc tgcacccgga gggtctgctg tcgttcactg tggcctccgc
     5881 gaccaacgtc gccgatccag accggcgacg tcaaccgcgc acccgccgca agggcaaagc
     5941 gacgcgagac tctctgacgg cagaccgaac cggaacgagc tcgttgtttg aagggcttga
     6001 aacgaaccag gaccaggaac tgctggcggc cgccgaggcc actccactct ggctcctgct
     6061 gcacgagcgc accgaccgcg gacttcggct ggaactttcg cggccgtcgg acatgacaga
     6121 gggaggcatc gtcaccaagt gggaagaccg catcctcatc gcgttcctcg acttggacgg
     6181 cgacctctcc atcttcgaca atccaaacga cagcggcgat atcgatgtcc gcgtcgaacc
     6241 ccgctgacca tcactcgcaa ggacgaatgt tcaacccatc ccgtctccgc ctggcgcgcc
     6301 agcgcctcgc cctgacgctg accaagctcg cccaactcag tggtgtatcc ctgcgctcgc
     6361 tcaccaatta cgagaccgga aagctcgcgc ccaacgagga gaatctgcgc aagctcgcgc
     6421 gaactttgga ggtaccaacg gcgttcttcg agcgagacgc tgtcgacacg atccccgtcg
     6481 aagccgcgag ctttcgcaag ctcagcaaga ccaccgcgac caggcgggac gccgtgcttg
     6541 ccggagcaag cctggtggtc gagttcttcg gcgtggtcga ggcgaagttc aagctaccgg
     6601 cgcccgacat tcccacgctg gacaagtttc cgcccgagca agccgctgaa cttctacgcc
     6661 gccggtggaa tctcggcgac aagccgatct ccaacgtggt ccacctcctc gaatcacgtg
     6721 gcgtccgcgt cgcagcacta cgccacgagt tcgacgacat cgacgcgttc tgcttcctcc
     6781 gcgacacgac tccgtacgtc ttcctgaaca ccgccaagac cggagagcgg caacgtttcg
     6841 acgccgctca cgaactcgcg catctcgtgc tgcacggcga gcaggacatg gaacccggca
     6901 cctcaaagga acgggaaaaa gaagccaacc ggttcgccgc aagcttcttg atgccggcca
     6961 gcgctgtcct cgaccagtcc atgcgcaacg ccagcctgga ccgcatcctc gccgcgaggt
     7021 cgtactggaa ggtctcggcc atggcgatga ctcatcgcct gcacgagcta cacctgctgt
     7081 ccgattggca gtaccgcagc acctgtgcgg ccctgtcaga gcagggatac cgcaccactg
     7141 aaccaggcgg cattgttccc gagacctctc aactcctgcg caaggtcatg ttcggcacca
     7201 tgggcagggt cagcgtgcac gacgccgctg cccacctcga cctgagccag gacgaggttc
     7261 gccagttcat tcgcaacctc gtgccgacgg ttgcatgatc gagcatgccg tcccggcgct
     7321 gcttccgccc gaatccagct gccgaggtga agctgatcat cgaattcggc gccgcagcga
     7381 acccgggtcc tcgccgacga ccggctggcg ccgcagtagg tcgcgccacc gtactccgcg
     7441 tgcccgccgg cgcagtcccc atgagcgaac gcgggccgca ttcgctcacg ggccaatccg
     7501 ccacacaaga gacagcacgc cgccgggccc gacggccagg tatatggccg tcgccctccc
     7561 tcggcgtttc actgcaacgt ttcgtcgtag aacgatcgga aggaacctgc tcgccgggca
     7621 gggcatcgaa atcccgatgg catgtggagg agcggaggac ctcgccgacg tgactacggg
     7681 tcaatacggt cacttcgcga acacggcgcc accgccgtag gggagcgcac aaacgcgagg
     7741 tccggtccag caaagcccga caaccaggac ccgagtcaat ccattgacgg gatctcctca
     7801 tcgaactctt ccgacgctca atcaccatcg gcacccgcgc ttgagaacaa gcggccgctt
     7861 tcccaggccg ccgaccgcga tgcggcaacg ccacgcgcgc cagcagaata gagtggccac
     7921 gatcgaccct gccgacgccc accaggtccg ccggcgcgcc tacagcccgt ccggcggcat
     7981 gtgaacccgc tacgtctggc acgccgctgg cgtcgacgag gtcatgcaga acccgggtgc
     8041 gtatcctgga gtgaatgacg ctcctccact cgtccctgat ccatccgtcg aataggccga
     8101 ccgtccatga tgatcgacta cgatgtgagc gacgattggt cggaggacgc ccctgactgg
     8161 ctgaagtctt tggtgtcgtc tctcgatcgg aaccacggcg ccagcaccgt cctgcctctc
     8221 acggtcatcg tcgaggagat cgccgagtgg atcgaactcg ccagcggcac cgacgcctgg
     8281 aagaagacag ccaaccggga ctcgctccaa tgggatctcg ataagtcggt gggtgcaatc
     8341 agttcatcgc tccgtgcgca catccctgga ccgctcgccg ccttccagac ggccttcggg
     8401 aacctcatta gtagctcttc ggcggtcctc agccagccac ccggaactcg cgtcgacgcc
     8461 gtctggacgg aagcgctctc gaccgcccgc aacttgttga acgctctcga ctcggaccaa
     8521 gccgtgcgcg cgagctggga cgacctggtc gcgaaagccc aggaccgaac ccttgcccga
     8581 cgcgagtacc acccgatcgt cgaactactg ttcgagcagt tgcagcggcg aggcctcagt
     8641 gtttcaacga gttgaccggt ggtgttgtgg tgcggctccg gggttttcgg cctgttgttg
     8701 atcaaattgg tgaggtctcc ggtagttcga tcaacgtcca agccgatcga gaacaccgga
     8761 gacctggagc cgctgctgcc cgtcggcaag aagccaggcc gcccaccgaa atggaccgaa
     8821 cggcaactca tcgccggcga ttccgtattg gctcgccctg gcatgatgcc ccgcccggct
     8881 acggctggcg tcgctgacgt gttcgcgcca ctcggtttcg gggccctcgg ccggcccctc
     8941 ccacatcgcg atgtgcgtcg ggaagtgctc aggcgcggca ccgtgccagt gccattcccc
     9001 cgggcggcgt gtagaccgtg tcgcccgggc gcatgacgac ccgcggtggt caggccgggg
     9061 cgagagggtg ccgctcgccg ggctgaaccc catccaaaat tccgagctgc ccggcacaag
     9121 agaacgcccg ggaaaagcag ttcgatgccc gcaggtgcga cacggaactg cggaaccgcc
     9181 gccggagatg cgaaatcgaa agaaaaccgc cgagaatggt tccggacaag cgtccgcaaa
     9241 caacaccacg cctgcggcgt atgtccaagt cggacacgcc ggacaccttc agatcatatc
     9301 gggcgaccag ctccgggaaa acgccggaaa acagctcgac aggtgtattt cgcagccagg
     9361 ctgcgatatc atctccaacc atggcggatg ctcgccgcga cagcttctgc tccatcggtg
     9421 atcgtcgtca tcgggtggtg gtgccgccgt gatctgggaa gtgctcgtcc tcggtttcgt
     9481 gctcagtctc gacaatttcc gggtttcgat cgcgctcggc accgtcccgt tcggtctgaa
     9541 gcgcgcggtg caggtggcgc tggtcttcgg gctctgggac acggtcatgc ccctggtggg
     9601 gctgttgatc gggcggcgga tcggggacgc gttcggggtc gttgccgacg tagtgggcgc
     9661 cgccgccctc ggcgggtacg gtctctacct cctcgcgtcc gccctgcgca atcccgagcc
     9721 ggaggaactg gaccatccgt gggcgctgtt cggcatcccg ctggcgctga gcctggacaa
     9781 cctgttcgcc ggggcgagcc tggggatcct cgggctctca ccgtggttct cggccgcggt
     9841 gttcggcgtc atgacggcgg tgctgtcgct ggtcgggctc cagctcgggc gggccgcggc
     9901 gcgcctcatc cgtatccgct cggacctgct gagcgggctc accctgatcg tcgccgccgc
     9961 gacgctgccg gtgctgttcg gcggctagcg ctcaacccgg ctagcgctcg acccggcgaa
    10021 cccggtgcgg gcgcggaatc agcggacgat cgccgccggg cgaggcggcg ttggcggcct
    10081 ccaccgcccg ggcgaccagg tggtggtcgg gcgagaggtg gcacaccggg tcggtgcggg
    10141 cggcgtctcc ggtgagcagg aaggcctggc agcggcagcc accgaaatcc agctcccgcc
    10201 gggcgcagct ccggcacggc tccggcatcc agtcggtccc gcggaacgcg gacatcaccg
    10261 gcgacccggc ccagatccgc tccagcgact cctcccgcac actggcccgc ggcaacggca
    10321 gggactgcgc ggccgggcag ggcagcacgt cgccgttcgg ggtcacggtc agctgccggg
    10381 acgcccagcc acccatgcag ggcttcgggt agcggctgta gtagtcgggc aggacgtaga
    10441 tgacgtccat cctgtcgcgc aaccgctcgc gggccgcccg cacgacgacc tccgccgccg
    10501 cgagctgggc ccggctcggc agcagcgcgt cccggttccg ccaggcccag ccgtagtact
    10561 gggtgttggc cagttccacc cggtcggcgc ccacctcctc ggccagcccg agcactccgg
    10621 cgacgcggtc gatgttgtgc cggtgcagca ccacgttcac ggtcagcggc cagcccagct
    10681 ccttgaccac gcccatcgcc tcgatcttcc gccggaagga cggggttccg gcgatccggt
    10741 cggacacggc cggctcgtcg gcctggacac tgatctgcac gtggtccaga ccggcggccc
    10801 gcagctgctc ggccctcggc cgcgagagcc cgaaggcgct ggtcaccaga ttggtgtaga
    10861 ggccgaggcc gtgggcgtgc gccacgaggt ccaccagatc gcgccgcagc agcggttccc
    10921 cgccggacag atggcactgc agaacaccca ggtccctggc ctcggccagc acccgccgcc
    10981 actcgtcggt ggtcagctcg ccggagtagc cggccaggtt caccgggttg gagcagtacg
    11041 cgcacgccag cgggcagcgg taggtcagct cggcgagcaa cccgaaagga ctatccatcg
    11101 ccggcctcca cccaacggcg ggcgacgagc cgcgtcagga accgccgcac ctcgtcgccc
    11161 gggacgctcc ggtagcgtgc gcccagctcg gcgacgatct cggccaccgt gtgccggccg
    11221 tcgcacagcc cgaggatgtc cgcaccgctg ccgttgagca ccaccaccgt ctcggggagc
    11281 agcaggatcg gacgctgcct ggtccggcag aaggacaacc ggacgtggcg ggcgagcctc
    11341 ggccggtcca ctgcggacag atcgggtcgg gtcgccgggt gcatgacgct cactccgggt
    11401 aggcctggtc gatggcgtcc atcaggctcc acaggacatc gcacttgaac gacaacgcat
    11461 cgacggcacg cgcccgggat tcgggtgacc ggcagtacgc ggtgaccacc tcgagagcgt
    11521 gctcgcagtc gcggggggcc tcctccagac gggcccggaa ataggcgagg cccgccggct
    11581 cgatccagga gtaccaccgc tcgaacgcgg ccagccgctc cgccatcagg tccggtgcga
    11641 acagctcagt gagcgaggag gccaccgcct ccacccacgg gcgggtccgg gcgaaatcca
    11701 cgtaggcgtc gacagcgaac cgcacgccgg ggaccaggtg ccggtggtcc tggacctctt
    11761 cgcgagtcag cccggcggcc tcggcgaggc gcagccacgc ctcgacgccg ccctccccgg
    11821 ggtgacggcc gtcgtggttg acgacccgcc ggatccagcg ccgccggacc tcgaggtcgg
    11881 ggcagttggc gaggatcgcc gcgtccttgc gcgggatgtt ctcctggtag tagaagcggt
    11941 tggccaccca gccctggatc tgccggcggc tcaggcgccc ggcattcatc ctgacgtgga
    12001 acgggtgccg gtcgtggtag cgccgcgaat gggcccgcaa cgcctcgacg aagccgtcgg
    12061 catcggttct cgtcgtcccg ctcgtcgccg tcacggccta cacctcgacc tcgaggccgt
    12121 cccgggccac ttccatgccg ctgccctcca cgacgcgccg ctcgggcgag tcctccagca
    12181 ggatcggatt ggtgttgttc atgtgcacga agatcgtgcg ccccacaccg agtgcgggga
    12241 gcagcgccag actgccgtcg ggcccgtcga tcggcaggtg ccccatctcc cgggacgtct
    12301 tgccggccag cccgagccgc accagctcgt cgtcacgcca gcacgtcccg tcgatcagca
    12361 ggcattggca gccctgcatt tccgcggcga gctcgcgcgt gagcgcctgc actcccggca
    12421 ggtacaccag cgtgcccccg ctgcgctcgt cggtcaggcg gtagcccacg acgcggccgt
    12481 ggtcctcgcc cggcccgaac cggctccgct tggtggtggg cacgtcgaac gcccggcagg
    12541 acagcccgcc gtccagggac atgcccacgc cggggaccac cgcccgccac tgtaccgggc
    12601 agtagcgctc gagtgccggc aacagccgcg agccgtcccg caatgtcttg tgcaccgcag
    12661 gcgtggtgta caacgacagg cccgcgcggg cttcgcgcaa caccagcagg ccgagcgtgt
    12721 ggtccagctc ggcatcggtg agcaacaccg cctcgagcgg cgtcgtccgg tcctcgcgcg
    12781 ggtgcagggc ggggaacgcc tcgatctgtg ttcgcacatc gggtgaggcg ttgatcagga
    12841 accagcgccg gcggtcggcg ctgaccgcga ccgacgactg ggtccgcgcg gggccggccc
    12901 cggagcgcac cgcggtgcac accgggcacc cgcagttcca ctgcggggag ccgcccccgg
    12961 cagccgagcc cagcacccgc agcaacacca cgccctccgt ctcctcaccg gccgggccgc
    13021 cggagggcgc cggacccgcg gtccagcgcc actccacgtc ccgtcagtcc tccatctgcg
    13081 cgacgtacat ggtcacttcg ggcgcgactc cgatctcctc gaactcgggc gtctcccaca
    13141 caacgagctc ggactccatg gatccacctc ctctccgcca cactccggca ggctgtccca
    13201 cggcgctacg acgtctccgg gagagcgaac acgatcagcg cgcttccgtg accggcgccg
    13261 agcatgccgg ggaggaatcc ctccgaccag gcgccccatc cgaccggcac ggcgacgtac
    13321 tgcctgccat cgaccatgta ggtcgtcggg ttgctgtggt gaccgctccc gcactggaac
    13381 tgccacagca gctcccccgt gcgggcgtcg agggcgttga actccccgga gggttcaccg
    13441 gcgaacacca gatcgccacc ggtcaccaac accgaggcgc acatcgggag ttcgttgcgc
    13501 cagcgccact tctcctcgcc gttggcgtcg aacgcgctga tgctgcccgt catgtcctcg
    13561 atgtccacct gaacaccggc gccccaatag ggaatgctct ccttgaactc ccggcgccgc
    13621 cgggtcgcgg tggcaccgac gtcctgcacc gggacgtaga acagctcagt cctggggctg
    13681 taggccgcat gggtccattc cttggcgccg gcgggccccg ggtagaagtg gaccggcacc
    13741 ccctcctcgt cggggtacac cttggccgtc accttgccgt cacgcgtgat cgccccccac
    13801 gtgatccggt ccacgaaggg ggtgacctgg accagcgcgc cgtcggtgcg atccaggacg
    13861 aagaagtagc cgttcttgtc gaagtgaccg agcagcttgc gcccctccga ctcgaacagg
    13921 atgcattcac cgatgctgtc gtagtcccac acgtcgtgcg gggtgcactg gtggtgccag
    13981 cggatctgtc cggagtcgac gtcgacggcg atgatgctgt cggtgtagag gttgtcgccc
    14041 tcgcgcacgc ctccgtcgaa gtcgggcgcc gggttgcccg tgcccacgta cagcaggttg
    14101 gtctccgggt cgaaggtgct ggtgatccag cagttcgcgc cgccacgcgc ccacgcctcg
    14161 ccgtcggcgg gccaggtgtc ggagccgggc tccccgggct tcggaaccgt gtagcagcgc
    14221 cattggtgct cgccggtctc gaggtcgaac gcgtccaggt ggccgcgcac gccgaactcc
    14281 ccgccggagc tgccgacgat gaccttgttc ttcacgatca gcggcgcgac cgtggcgctc
    14341 tcgccggccc gcacgtcacc gtaggtctgg tcccagaccc gtttgccggt ggtggcgtcg
    14401 agcgcgagca cgtgcgcgtt cgccgtcacg aagaacacct tcccggccgc gacggcgacc
    14461 ccgcggttga cgttcccgca gcacagcgac acgtcgaacg ggaccgcgtg cttgtaccgc
    14521 cagatctcga cacccgtctt cgcgtcgagc gcccagaccc agccgtccca gccggcgagg
    14581 aacatgaccc cgtcgacgac gatcggggcg gcctcgaacg agtaggtcga cgcgcccgcg
    14641 atgaggccgg tcgtgccggc ctggaacacc cacgcgggac cgagccgctt gacgttctcg
    14701 gtgttgatct ggtccagcgg gctgtaccgc tggccgttgt aggcgccgta gtaggtgagc
    14761 cagttctggg gctcggaccg ggcgttcagg atgcgctcgt acccgacgtc gcggaccacc
    14821 ggcggcgcga cctctccccc ggcgaccttg ccgctcagcc ttccttggtc gatggcctcg
    14881 cccgcgtcca cgtactcgac cgtcatcgtg tctcctccaa tctagggccg cggctggtcg
    14941 ggacggtcga ggcgagcctc cggcggaacg tctcccagca cgacgatggc gccggtcagt
    15001 ccccggccct cgtcgttgcc cgtgggcgag ctgaaccagt agtagccagg gccgtcgagg
    15061 ttgagtgtcg cttttccttt cgaatggttc accagccaga tgaatttccg gtcgccgttg
    15121 ctcggcagca gcgcgcaatg cgtgttcagg tcgtcgttga cgagttcgag ttcgatatca
    15181 cccccgtgcg gcatgacgag aatggagggg tcccagctga tctcgtcggg ccggatccgg
    15241 atggtcgcct ccatccggcc gtccgcccgc tccgtcgcct tcccgatgct cccggtcccc
    15301 agcacctgac ccagtgccgc tttgttctgc gcgtccaacc cgagctcgtt cagcaggtcg
    15361 acccgttcct gagcggtcgt caccgggctt cacctcctca tccagaatcg caaatcattg
    15421 gcacaagaag cacgcagccc gacatggcga ttactattca cgaattgcga atcaccaacc
    15481 gggaaaaact ctacgcggcg gcaatcgcac cgacaagggc gcgcgcgaag tcgggcgcac
    15541 cacgccgttc gtccgccacc ggctaccgct cgtacccgat tcgccgccgc cggcgggttc
    15601 aggcgaggtc gtaccggtcg aggttcatga ccttgtccca cgcggccacg aagtcgcgca
    15661 cgaacctctc cccggcgtcg tcgctcgcgt agatctcggc gagagcccgc aactcggcgt
    15721 tcgagccgaa cacgaggtcg acgcggctgc cggtccacct gacctcgccc gtggcgcggt
    15781 cacggcccac gaacgtctcc gcgcccggaa cggacccggc cgccgccgtc cactcgatgc
    15841 ccgggtcgag caggttgacg aagaagtcgt tcgtcagcgt ccccggggcc gaggtgaaca
    15901 cgcccagcgg ggactgcccg gagttcgcgt ccagcacgcg caggcccccc accagggcgg
    15961 tcatttcgag cgcggtgagg ttcagcagct tcgcccggtc gacgagcagg tgctccgacg
    16021 gcagccggct gcccttccca cggtagttgc ggaacccgtc ggaggccggt tcgagcgccg
    16081 cgaaggattc cacgtcggtc cactcctgcg aggcgtccat ccgccccggg gtgaagggga
    16141 cctcgacgtc gaagccggcg gccttggcgg cctgctcgac cgcggcgcat ccgccgagca
    16201 cgatgagatc ggccagcgag atccgcttgc ctctggtttc ggtgctgtcg aaggactcct
    16261 ggatcctctc gtacctgcgc agcacctgcg ccagcgtgtc cgggtcgttg acctgccagc
    16321 cgcgctgcgg ctcgaggcgg atgcgcgccc cgttggcccc gccacgcttg tcgctgacac
    16381 ggaacgtcga ggccgacgcc caagcggtgg acaccagccg ggccacgggc agcccggagc
    16441 cgagaatcgt tgccttgagg gcggcgacgt cgtcggcgtc gaccagctcg tggtccacgg
    16501 cggggatcgg gtcctgccac agcagccgct cccgcggcac cagcgggccg aggtagcgct
    16561 ggatcgggcc catgtccagg tgcgtcagct tgaaccagac ccgggcgaag gcatccgcca
    16621 gctggtccgg gttgtcgagg aagcgccgcg aaatccgctc gtagaccggg tcgaaccgca
    16681 gcgcgaggtc cgtcgtcaga accgtcgggg cgtgccgttt cgacgggtcg tgggcgtccg
    16741 gcacggtgcc ggccccgccg ccgtcccccg gaatccactg ccacagaccg gcggggctga
    16801 gcaccaggtc ccacgcgtag ccgaacagcg tctcgaagaa gctgttgtcc catctcgtcg
    16861 gcgtgggtgt ccacgtgccc tcgagcccgc tggtgatggt gtcggcgccc tttccggtgc
    16921 cgtagctgct cttccacccc aggccctgct cctcgatcgg cgcgccctcg ggttcggggc
    16981 cgaggtggcg ttccggatcg gccgccccgt gggtcttgcc gaaggtgtgc cctcccgcga
    17041 tcagcgcgac ggtctcctcg tcgttcatcc ccatgcgccg aaacgtctcg cggatgtccc
    17101 gcgccgaggt gagcgggtcc gggacggtgt tcgggccctc cgggttgacg tagatgaggc
    17161 ccatctggtc ggccgccagg gggcgttcca gctcccggac cccgcggtgg cgtccatcgc
    17221 cgagccagac gggctcggga ccccagtcga cgtcctcgtc gggcgcccac acgtccgcac
    17281 ggccgccggc gaagccgaac gtcgtgaagc ccatcgtctc cagggcgcgg ttgcccgcga
    17341 agatcatcag gtcggcccag gacaccttgc gtccgtactt ctgcttcacc ggccacagca
    17401 gccggcgcgc cttgtcgagg ttccggttgt ccggccagct gttcaccggc gcgaagcgct
    17461 gcaagccggc cgccgggccg ccccggccgt cgtcgatccg gtacgtcccc gcggcgtgcc
    17521 acaccatccg gatcacgagc gggccgtaat ggccgaagtc ggcgggccac cactcctgcg
    17581 aggtcgtcag caccgcgtcg acgtcccgcg ccagggcgtc gaggtcgagc gtccggaact
    17641 ccgcggcgta gtcgaagtcc tcggccatgg agtggtttcg ccgcaggccc gtcaggtcga
    17701 gccggtccgg ccaccagtcg cgcaggcgcg cgcccgcggc ccggtgggtg cgcggctcgg
    17761 acgggacgga gaggccgagg ccgccgccgg cagtcgcggg ggcggcgggg gcgtccgcgc
    17821 tctcagccat gggaatcctt tccgggcacg gagctcagat gtccagcgcg cggcgcacgg
    17881 ccggcacgtt ccgccgggaa accggcacca tcgtgttccc cccgtcgtcc atgatcaggg
    17941 acagctcgcc cttgacgccc cgctcgacct cgcggacgcg gctgaggttg accacgtacc
    18001 ggcggtgcac ccggaggaaa ccggcgtcgg ccagctcgcc gtcgaacttg tccaggcccg
    18061 cggacgcggc acgcaaccgc ccctggtcgg tgcacagcca cacgtcgttg ccttccgact
    18121 cggcgaagga cacctccggc agccgcaaca gaaccatgcg gttgtcgcgc gtcgcgacca
    18181 cgcggcgcgg ccgtggtcga ggctgcgcgg cgccgtccgc ccggggcacc ggcgccccgt
    18241 cgggatcgcc gaaggagacc aggttcccga tcaggtgacc ggaggtgaag acaggccgga
    18301 tgctgatcga ggtcggctcg tcggcgaggc gggtgaagat ctgcgtcgag ccgacccagt
    18361 cgggattgcg ggccgcctgc ctgctggcgt accgcacggc cccgatcagt tccggcagcc
    18421 cgggccgcca ccgcagcgtg gggtcgaccg ccggagtggc ggccgggacg cccatgagca
    18481 cgccggccgt ctcgtcggcg atcaccacct tgccggcgtt gtccagcgcc gcgaggcccg
    18541 cggtcgagcg ggcccgggcc tggctgaacg ccgcgaccaa ttccgcgccg ctgtcccggg
    18601 cgcgcctggt cagcatgcgc tgggtcctgg tgaccgcgtt cgccagccag cttcccgcgg
    18661 aggcgggcag ctggctgcgc cagcaggaga tgttcagcac cgcgatcggt tccctggtca
    18721 ccacgtcccg cacggcgacg ccctcgcaga accagtcgtg gaacgcctgg caccagtgct
    18781 ccgcaccccg gatcagcacc gggccgtgcg cctcgagcgc cgtgcccatg ccgttggtgc
    18841 cggccgcgca ctcggaccag cagaaccagg gcgccaggtt ggcatcggtg gcccgggcga
    18901 gcgtggcctg gtcgccccac tcggcgagga tccggccggt ggcgtcggtg acggtgacga
    18961 cgccaccgag gttgcccact tcatgtgcca cggaggcggc gcgaaaaccc agctccgcga
    19021 acacgacatc gtgctcgggc gcggggtcgg gcttcgcgac ggccaccggg acctccctga
    19081 ggtgggggtc gacccggtac tggtcccggc agcgatacca ggagatcgcc accacgggcc
    19141 ggacaccggg aacctgatcc tcaccccgca cgaaccgttc ccacgccgcg agcacggtgc
    19201 cgctgcccgg gttcccggcc acgggctcgt gccgatgcgc atccctcatc gtggagaacc
    19261 gcccttggtc ccgcccaacg cccggcggcg tgcgcgccgt cccgccacgg ctcgtccggg
    19321 ccgcgcaccg cgtcgtgcgt cctccgcttc accactcgtg tcagggccgg taccggaccg
    19381 gcactgccca gggtaggccc aaattccggc agagctaccc ccgatctcgg cgccggtcag
    19441 ccagaacgtg gagcaactcg cgaatcgtca tgcccatgcc gcccggcttg ctcgacatcc
    19501 ttcacaccaa gccgggtgcg cggtccgcgg acgccggagg tggtcgccag ccagccgccg
    19561 aggaacgccc cgacggcggc ggcgcacatg gccggcatgc gggaggttga cgcgcccctg
    19621 cccatgaggc gggccgggac gatcgcctgc cggagggagg gcccgagcac catcgtggcg
    19681 cccattccgg ccccgcagac ggcgagcgcc aggccacgta cgggttcgag gcggaggcga
    19741 ggctcaggat ggccagtcct ttgaccgcgg ccgtgcaggt cagtgcggtg ccggtgccga
    19801 gcctccggcc gagccgggag gcgatgcccg cggcgagcag gcttccggtg gcctccgcgg
    19861 tgagcgagca ggccggagcc gtagcggaac cgcccgcccg agcgcgggca gcacactgcc
    19921 cgcgggcccg cgaagccgga cgtgggtctg ggctccgcgc aaccgagcct tggcgcgctc
    19981 caggcgtgcg gggtcgcgac cgagcagatc cggcagatag gccgtggcgg aggtgtcgaa
    20041 gaagagtcca ccgaggccgg gcaggaaggc gacgaccgcg agcagcaccg cacgcgccgc
    20101 gtccacgacc cacatcgtcc gccggcggtc ccagcggtcc accagcgcac cgccgagcac
    20161 gccgaagatg agccacggca ccatcccggc ggccgtgacg acggcgagcg ccatcggatc
    20221 ccgcgtcaac gtcagcccga gcaggggcag cgcggcatgc gacaccccgt cgcccggcga
    20281 ggacaccgtc cgcgcggtcc acagccgccc gaacccggcc ggcaacttcc gaacgcccga
    20341 ggtcactggg catccccgtc ggcccgctct cccattgccg ggtggaacag ggcgaagacg
    20401 agtgaggcgt ccggcagcga cggatccgac agttcccggt actcgtccgc cagcgcgtgc
    20461 agccgcgctc ccagcacggc gaactgctcg tcggtgagcc gcaggtgagc catccgcacg
    20521 tgccgttcgc cgtccaccgg cgacgcctcc aggtccgcca ccgcgtgccg catcagcacg
    20581 cccggcccgc ccgcgcccgg atccgacagc acgatcgacc gcgcggcaag gggtttcccg
    20641 actgtccggt tgtgcgctgc cggtcgcgct actccgtgcc gtcccccggc aggcgctccg
    20701 gcagtcccag ccgcgggaac tggtcgtcgt ggaaggtgat gatctccgtg atcgctccgg
    20761 cggtgatgcg caggacgtcg atcgtcagcg gcagcgccgc cggcgggcag ctcgtcgagc
    20821 agccggtccg ggtagggctg cagccacggc acctcgccgc cagccgcggg ctccgggccg
    20881 cacttggcga gcaggtccag gcaggcgttg gtggcgatcc ggtacagcca ggcccggaac
    20941 gtcgaccgcc cctcgaaggt ctcccgccgc cgccacgcgc ggaggaacgt ctcctgcacg
    21001 gtgtcctcgg cgtcctcgaa cgagccgagc atccggtaac agtgcacgtg cagctcccgg
    21061 cggtgccgct ccgccagccc cgagaacgtc gcctcgtcga cctcgcccat cccgctcacg
    21121 cccagcgccg tccacgtgtc cgcacccatc acgtcatcct tccgcctcgt ggtctgccgt
    21181 cgcaggtgtg acggccgcgg gccagaaaac tcatcaccag gtgcgaaagc ctcttctgcg
    21241 cgagcgggcg cggtggcagc gtggagggtc ttccgcaacc gccggccgtg gaggacccga
    21301 tgactctgga ccccaccttt taccgcagcc ccgcggatgc gatcgccgca cccgccgaac
    21361 gcctggccta catcgtcgcg ttcgaccgca gtgcccagcg gccggacgca ctcaccgtgc
    21421 tcgacaccga ccccggatca cctgcctacg gcacgatcgt gggctgggcc gacctgccca
    21481 cacggggcga cgagctgcat cacttcgggt ggaacgcctg cagtagcgcg tacgcgcacg
    21541 ccggacacga caccggcgga ctttcccggc gctacctgct gctgcccggg ctgcgttcgt
    21601 ccaacgtgca tgtctacgac accgaacctg acccgcggca tccgaggctg gtgcggaccg
    21661 tggcggccga cgagctcgcg gcgaaggccg gctactcccg gccacacact ctgcactgcg
    21721 ggccggacgg ggtgtacctg tcctgcctgg gcggggccgg ggaggacggc cccggcggga
    21781 tagcgctgct cgaccatgac acgttcgacg tcgtgcgcgc gtgggagacc gagcgcggac
    21841 cccagtacct ggcctacgac gcgtggtggc acctgaacca gaacacgctg gtcacgagcg
    21901 agtggggcac cccgtcgatg atcgaggacg ggctcaaccc ggaactgctg ctcggcggcg
    21961 agtacggcca cgcgctgcac ttctgggatt tcgatcaagg ccgccacctg cagcgcgtcg
    22021 acctcggcgg gcagtaccag atggtgctgg agctgcggcc gtcgcacgac cccgaggcga
    22081 cctgggggtt cgtc
//
