LOCUS       NZ_BNAU01000001        21616 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Amycolatopsis deserti strain CGMCC 4.7677 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BNAU01000001
VERSION     NZ_BNAU01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Amycolatopsis deserti
  ORGANISM  Amycolatopsis deserti
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 1754180)
  AUTHORS   Sun,Q. and Zhou,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 82X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014653945.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:43:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,561
            CDSs (total)                      :: 7,498
            Genes (coding)                    :: 7,407
            CDSs (with protein)               :: 7,407
            Genes (RNA)                       :: 63
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 91
            CDSs (without protein)            :: 91
            Pseudo Genes (ambiguous residues) :: 0 of 91
            Pseudo Genes (frameshifted)       :: 32 of 91
            Pseudo Genes (incomplete)         :: 64 of 91
            Pseudo Genes (internal stop)      :: 8 of 91
            Pseudo Genes (multiple problems)  :: 12 of 91
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:49:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 948910
            Orig. end                         :: 970526
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BNAU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21616
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21616
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21616
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11616](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11616)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            145..987
                     /locus_tag="IE290_RS04505"
                     /old_locus_tag="GCM10017786_09240"
     CDS             145..987
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987836.1"
                     /locus_tag="IE290_RS04505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09240"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_191243188.1"
                     /transl_table=11
                     /translation="MTTTVAPQAQVLPDGEAATYADWFACLAEPTRVRLLHAVATAPRG
                     ITVGALTDLLGISQSTCSHHVRKLADVGFVQVRKEGTATIVTVNAACCAGLPHAADAVM
                     GLLAPRPCCPEDVPADVTVRALRDDDWPAVRRIYGEGVDTGVATFETTVPSRATLDAKW
                     IDGQRWVAEIDGTVVGWAAATPVSTRECYSGVAETSIYVADGHRGRGIGKALIRRQVIA
                     LDEAGYWTLQTSIFTENRASLALHHSAGYRTIGIRERIAQRDGTWHDTVLLERRNNIS"
     gene            1109..1915
                     /locus_tag="IE290_RS04510"
                     /old_locus_tag="GCM10017786_09250"
     CDS             1109..1915
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE290_RS04510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10017786_09250"
                     /product="hypothetical protein"
                     /protein_id="WP_191243189.1"
                     /transl_table=11
                     /translation="MPQKERPNERMAREIVADTLRVPVTCHDDNTQGSMVDALIHYPDG
                     SLGAMEIVADHDDRFNKMWDALEKAGHSLPVGGLRRSWNVVLGHAADLRRVRAELPDLL
                     RGMEDLEHSDLRRVGRKRNPEVTDRAAALGVRMAYVVDHTPPGTVHLRAEGWSGFIETV
                     SLANWVRDVLARHPGKQNKLLAHDGARERHIFIWATMGSNFSIQDLLMRREQAAIAEQA
                     APNLPEGISHVWVAGSMSSQGVAGWSADRGWWWTPWRFPRRVDDAE"
     misc_feature    complement(2388..2403)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     misc_feature    complement(2527..2543)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 24.28"
                     /tool="antismash"
     gene            2655..4310
                     /locus_tag="IE290_RS38470"
                     /old_locus_tag="GCM10017786_09270"
     CDS             2655..4310
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.5"
                     /locus_tag="IE290_RS38470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09270"
                     /product="recombinase family protein"
                     /protein_id="WP_373300414.1"
                     /transl_table=11
                     /translation="MSTEDQQDPEASRNWQRARAQALIDRHGKLVAEFFDIGQSRSIPW
                     KRRPEAARLLEAMRDPDRGFDAVVIGEPQRAFYGNQYGLTFPVFVHYGVELWVPEVGGA
                     VDPESEAHDLVMSVFGGMSKGERNRIKIRVRSAMAAQASVEGRFLGGRPPYGYRLADAG
                     PHPNPAKAAEGKRLRRLEPDPVTAPVVQRIYREYLGGRGMFAIAEGLTRDDVPSPSAHD
                     RARNRHRSGIAWSKGAVRVILSNPRYTGRQVWNKQRKDEVLIDVEDVALGHETRMRWNA
                     RDKWILSDDLVHEALIDAETFERAQQVLGARGAGRTTRERQRTRHRYVLRGLVRCGLCG
                     RRMQGQQSREVLFYRCRFPAEYGLANKVEHPRNVYLAERDLLGPLDAWLAKSFAPHRLK
                     DTVDTLYEAQAADDDEHAALAAMRVVEECDQALRRHRAALEAGADPQLVTRWMAETQAR
                     RAETLAKARPAARPQRLSKDEIQGLIDSLGDLRRTLIHAAPEDKAAVYQQLGLQMIYHP
                     GKRTVRVETNLDPHSWGYGTCPRGDLNPHALYGH"
     tRNA            complement(4266..4349)
                     /anticodon=(pos:complement(953224..953226),aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="IE290_RS04520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="GCM10017786_t00040"
                     /product="tRNA-Leu"
     gene            complement(4266..4349)
                     /locus_tag="IE290_RS04520"
                     /old_locus_tag="GCM10017786_t00040"
     gene            4506..4931
                     /locus_tag="IE290_RS04525"
                     /old_locus_tag="GCM10017786_09280"
     CDS             4506..4931
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419101.1"
                     /locus_tag="IE290_RS04525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09280"
                     /product="YkvA family protein"
                     /protein_id="WP_191243190.1"
                     /transl_table=11
                     /translation="MPGWLTGVLIAAGVVLASWVLLILLARLLPPGLARDLARFLPDCV
                     ITVKRLRTDPRVPRGAKLAVVFAGLWVLSPVDLIPEFLPVIGPLDDVVVVALALRYAAR
                     RVPPDVLHDAWPGNPGLLDRLIGRRGEKSPDTDTSGA"
     gene            4954..5832
                     /locus_tag="IE290_RS04530"
                     /old_locus_tag="GCM10017786_09290"
     CDS             4954..5832
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017987845.1"
                     /locus_tag="IE290_RS04530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09290"
                     /product="DMT family transporter"
                     /protein_id="WP_191243960.1"
                     /transl_table=11
                     /translation="MDRRAMVAALTTVVLWASAFVAIRAAGEYFAPGALALGRLAAGTL
                     TLLVFLLIRREGLPKREAWPGIAGAGVLWFGAYMVVLNWGEQLVDAGTAAMLVNVGPIL
                     IALLGGWLLREGFPGRLLAGLAVSFAGAVVVGLSMSGRGHAPVLGVVLCLLAAITYAGG
                     VVSQKPALKHASALQVTTFGCLIGTVACLPFTGQLLDGLATAPAGATLSMLYLGVFPTA
                     LAFTTWAYALARTTAGKMGSTTYAVPAVVVLMAWAVLGEVPGWLSLAGGVLCLAGVAVS
                     RTRRKREPVLT"
     gene            5873..6316
                     /locus_tag="IE290_RS04535"
                     /old_locus_tag="GCM10017786_09300"
     CDS             5873..6316
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419103.1"
                     /locus_tag="IE290_RS04535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09300"
                     /product="hypothetical protein"
                     /protein_id="WP_191243191.1"
                     /transl_table=11
                     /translation="MTDARLDDDHPEADRYDRATVEAVGKLTEALETLEVARGHLYQFH
                     RMTGTTDFAVGEAVELLRKAGHDELADRIARELVGRNVLPGRWTFQVVEDFDDTYYQPF
                     RAFERQARELTGGRRHLFEAELKRERRTRGVAGHEATPDERVG"
     gene            6318..6800
                     /locus_tag="IE290_RS04540"
                     /old_locus_tag="GCM10017786_09310"
     CDS             6318..6800
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419104.1"
                     /locus_tag="IE290_RS04540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09310"
                     /product="MSMEG_6728 family protein"
                     /protein_id="WP_191243192.1"
                     /transl_table=11
                     /translation="MQTFLPFPGFADTARVLDARRLGKQRVETLQVLRALTVPNYGWRH
                     HPAAKMWTGYEEVLTRYGLEVCRVWCAAGRTDTCATKLTDDLARAIGVTEPRDEQALRE
                     AGEMPPWLGDPEFHRSHQSALLHKDPEHYRRFFDGVPDDLPYVWPASDRPSRLVHS"
     gene            complement(6752..7777)
                     /locus_tag="IE290_RS04545"
                     /old_locus_tag="GCM10017786_09320"
     CDS             complement(6752..7777)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419105.1"
                     /locus_tag="IE290_RS04545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09320"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_191243193.1"
                     /transl_table=11
                     /translation="MAPRWSRKWPREWPLQPIPRTPWARQEPTYREAKPSLIEAALKRA
                     EARPSGNWYVFAASRDVRGDRPYGFSVAEIELVAWRDRAGKLLVGPGACPHLGAPMALG
                     RVDDGGLRCRWHGLRLDERSCRPAFDDGVLAWVRLDHVGGEEPLPSPIVPARPAGGVDS
                     VARLEGVCEPRDIIANRLDPWHGSWFHPYSFTRLKVLSAPAEVDVAESDDRFVVSVTFR
                     VTPTLGVPVEAEFTCPGPRTIVMRITDGEGVGSVVETHATPLGPGRDGRPRTAVIEAVV
                     AASERPGFRVARAAAPALRPLMRRAAARLWKDDLAYAERRYRLRGQEWTSREGRSEAGH
                     T"
     gene            complement(7780..9273)
                     /locus_tag="IE290_RS04550"
                     /old_locus_tag="GCM10017786_09330"
     CDS             complement(7780..9273)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647219.1"
                     /locus_tag="IE290_RS04550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09330"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_191243194.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3e-07, bitscore:
                     26.6, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 4.8e-16, bitscore: 55.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRRAVRHRAPAGALSPGVPRSVVVVGGGIAGLTAATGLAERGV
                     AVTVVERENELGGRVSAWTDRLADGSTVSMSRGFHAFFRQYYNLRALLRRTDPDLARLR
                     PVDDYPLVDAEGRRDTFRGLPRTPPWNALAFALRSPTFRLADLFRLNARAAAPLAAVSV
                     PGTYERLDDVDAATFLEHINFPPAARHLAFEVFSRSFFAPPSRMSAAELATMFHLYFLG
                     SSEGLVFDVPDSAYDTALWEPLRAYLAGLGVRFRTGTEVGGLERDGSRWAVDGVAADGV
                     VLAADVAGLQSIVSASPDLADDEWRSRVLRLRIAPPFLVHRLWLDRPVAPDRPAFLATG
                     GLDPLDNISVLNRYEREAASWAARHGGSVVELHAYACADEVTVLRNQLVDRLHQLYPET
                     AGARVVGELVQWRRDCPLFGVGDFARRPRVRTPFDGVVLAGDGIRIDLPVALMERAAAT
                     GWHAANCLLARWGLAGHELTTVPVRGRFAPLRALAALGG"
     gene            complement(9270..10004)
                     /locus_tag="IE290_RS04555"
                     /old_locus_tag="GCM10017786_09340"
     CDS             complement(9270..10004)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419107.1"
                     /locus_tag="IE290_RS04555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09340"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_191243195.1"
                     /transl_table=11
                     /translation="MSPDRTGLARHEVPGAFDTGAAAYDRLVGANPGYHEHLRLSARRM
                     RLPGGGRGLRLLDAGCGTGASTAALLAAAPRAEIVAFDASAEMLAQARRKSWPPTVHFV
                     HSHVEDLASSGIAGPFDAIFAAYLIRNLADPDGQLRALRALLKPGGTFAAHEYSVRDSP
                     VARAVWHAVCWSIIIPAGRLATGDATLYRHLWRSVLSFDGAARFRQRLAEAGFTAVHSE
                     TMTGWQRGVVHTFLATNPEETA"
     gene            complement(10001..10321)
                     /locus_tag="IE290_RS04560"
                     /old_locus_tag="GCM10017786_09350"
     CDS             complement(10001..10321)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019814772.1"
                     /locus_tag="IE290_RS04560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09350"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_191243196.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 1.3e-17,
                     bitscore: 60.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGLGYTLPAVLAVLAVCGWELAYLRTGLFGKPAYWISMAIVVGF
                     QIPVDGWLTKLSAPIVLYAPEHTSGLRFPWDIPVEDFLFGFALVTAVLLLWERRTARQE
                     DA"
     gene            complement(10318..10653)
                     /locus_tag="IE290_RS04565"
                     /old_locus_tag="GCM10017786_09360"
     CDS             complement(10318..10653)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419109.1"
                     /locus_tag="IE290_RS04565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09360"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_191243197.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 2.7e-22,
                     bitscore: 75.7, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRYQYLLVLAGCLAITLPLEFLGARVYRRPVALARAVLPVALVF
                     LVWDAIAIAGGVWWYNPAYVTGVRLPFAIPLEELMFFLVIPVCGVLTYGCVQAMLGRLR
                     TLRKVRR"
     gene            complement(10654..11616)
                     /locus_tag="IE290_RS04570"
                     /old_locus_tag="GCM10017786_09370"
     CDS             complement(10654..11616)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982252.1"
                     /locus_tag="IE290_RS04570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09370"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_191243198.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.4e-121,
                     bitscore: 400.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.3e-60,
                     bitscore: 201.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGALDAAGITEPRLRAAYVRCRRLNAEHGRTYYLATRLLTKAQR
                     PAVHALYGFARFADDIVDTAAPGTDPATRLEALSADLFAGLERGHSDDPILAAVVDTAA
                     RYGIRRDLFAAFLDSMRMDLTVTGYADRAALDRYVYGSAEVIGLQMLPVLGTVGEPGEA
                     APYAAALGKAFQLTNFLRDVAEDLDRGRVYLPADELAAFGVDRDLLLWCRRHGRTDPKV
                     RAALAAQHAATREIYAYARAGIDRLHPVSRPCIATALVLYSEILDRIEAAGFAVFAHRA
                     RVGRGRRARLAVTGLARAMWARRGRRAADLTGAATERWA"
     gene            complement(11613..13112)
                     /gene="crtI"
                     /locus_tag="IE290_RS04575"
                     /old_locus_tag="GCM10017786_09380"
     CDS             complement(11613..13112)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423228.1"
                     /locus_tag="IE290_RS04575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09380"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_191243199.1"
                     /sec_met_domain="DAO (E-value: 5.5e-21, bitscore: 72.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVTGPAERIVVVGAGLSGLAAALHLAGRGRQVTVVEREPVPGG
                     RTGRLDLDGYRIDTGPTVLTMPDLVDETLAAVGDSLADRLDLVPVTPAYRARFADGSSL
                     DVHSDPEAMAEAVRSFAGPSEADGYRRLREWLTRLYRTEFDRFIAANFDSPLALVTPHL
                     ARLVAMGAFGPLDRKIGRFLRDERLRRVFSFQSLYAGQSPQHALAVYAVIAYMDTVAGV
                     FFPRGGLRALPDALAAAAADAGVEFRYGTEVTALARSGARVTAVETTGGSLPADAVVLT
                     TELPAAYALLGRTPRRPVPLRPAPSAVVVHVGTRQRCDTAHHTILFGAAWRRTFHELIS
                     QGRLMSDPSLLVTRPTATDPALAPDGRDLLYVLAPAPNLRRGPVDWDRVGDAYADEILG
                     HVAERLLPGLDGSIEARHVVTPADWARQGMLAGTPFALAHTVAQTGPFRPRNLVRGTEN
                     VVLAGGSTAPGVGVPTALVSGRLAADRITGARVTRPLVAAP"
     gene            13249..14151
                     /locus_tag="IE290_RS04580"
                     /old_locus_tag="GCM10017786_09390"
     CDS             13249..14151
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonatesMeIsocitrateLyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010224463.1"
                     /locus_tag="IE290_RS04580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09390"
                     /product="oxaloacetate decarboxylase"
                     /protein_id="WP_191243200.1"
                     /sec_met_domain="phosphonatesMeIsocitrateLyase (E-value:
                     1.3e-87, bitscore: 290.2, seeds: 9, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7.1e-57, bitscore:
                     189.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDLLGHGSAPRKRLRELLAAPGPLVAPGAYDALTARLIEQAGFD
                     VVYMTGFGTTASLIGRPDVGLLTGTEMVDNARRIVAAVDVPVIADADTGYGNALNVVRT
                     VQAYEQAGVAGIHLEDQVSPKKCGHLSGKAVIPREEMVGKLRAAVAARRDPDFVLIART
                     DAAAVHGLADAIDRARAYAEAGADLLFVEAPTSEADLATVARELSGVAPLVFNWAEGGR
                     TPPLSLQRIRELGFSLVLYPIGTLLAATAGVRALLDTVRRDGTPAAALPGLPLFGEFTD
                     LIGLPEVSDLEARFAGESG"
     gene            complement(14148..15068)
                     /locus_tag="IE290_RS04585"
                     /old_locus_tag="GCM10017786_09400"
     CDS             complement(14148..15068)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982255.1"
                     /locus_tag="IE290_RS04585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09400"
                     /product="glycoside hydrolase family 43 protein"
                     /protein_id="WP_229874187.1"
                     /transl_table=11
                     /translation="MTCLGILLSSALLPGAVAQAAPAPRVLLDQDFPDPDVLKIGTDYH
                     AFATTGPSGRIPVAVAKDADGPWQVTGDALAADPSWVDPKGGYWAPDVTRRADGTFLMY
                     YSAVSKADGHRCIGAAVGNSVAGPYQPTGDAPLICDPGDRGDIDPQTFQTRDGTRYLLY
                     KGEHPGGGASAIFVQKMTQDGTAPAGPRTEILRADRPEEKGIVEAPVITQRGGQYVLFY
                     SADDFRNAGYQTRYATAPALTGPYTKADQPLLTTDSIGHAAEGPGGADIVGGRIYFHGW
                     LGGQRVARGLFGMNLEFVKGVPQVS"
     gene            15226..16137
                     /locus_tag="IE290_RS04590"
                     /old_locus_tag="GCM10017786_09410"
     CDS             15226..16137
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010239481.1"
                     /locus_tag="IE290_RS04590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09410"
                     /product="NAD(+)/NADH kinase"
                     /protein_id="WP_191243961.1"
                     /transl_table=11
                     /translation="MTGESRTLGLVIHPTRSVESSVRTVTEHAWTRGVEVIVREADAAR
                     VPGVAAVSEADFVARVGAVLSLGGDGTMLGAMRLVMARPVPVLGVNHGHLGFLVEIAPE
                     QLPDALDRLVRGEYTIEPHSCLVASAGEAVLAGFNDVVLARAGRAGAVSVDLVVNGRQY
                     GYYKCDALILATPTGSTAYNYAAGGPVLSPSAEAIAVTPVAPMAGISRPIVLGPQDEIR
                     LHVAPDSAPVAVEVDGTAAGALGPDAVLTTVLRPEAAQVVRLAAGEHASRSRVKLSLLD
                     LPLRPDQLLELIPEHLRRRLDP"
     gene            16341..16937
                     /locus_tag="IE290_RS04595"
                     /old_locus_tag="GCM10017786_09420"
     CDS             16341..16937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423231.1"
                     /locus_tag="IE290_RS04595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09420"
                     /product="HdeD family acid-resistance protein"
                     /protein_id="WP_191243202.1"
                     /transl_table=11
                     /translation="MAVHQPSGAFRVSFGEGMARELRRVTGRWWMVALLGVATLVLGVL
                     LLANLATAVGTLAVLVALALLFEGFDEILTAERHRTRWPSYLLGLVWIAVGVIALAWPG
                     ITLLTLAVVVGAGFVLAGVGQIAASVAWRARLPMWGLWLGLGVVTLLIGLVALVWPDLT
                     ILTLAIWLGLALVMRGLGALWFGLQLRRAHRAVEA"
     gene            complement(16939..17334)
                     /locus_tag="IE290_RS04600"
                     /old_locus_tag="GCM10017786_09430"
     CDS             complement(16939..17334)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982262.1"
                     /locus_tag="IE290_RS04600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09430"
                     /product="DUF5313 family protein"
                     /protein_id="WP_191243203.1"
                     /transl_table=11
                     /translation="MTERRRPNPIQWLWYALGGRLPEEHREWVLHDVTAKTWIWRHAAR
                     AAVLLLPLMLVWLLLPGPLTLRLSLVLMAGLVGFFYSLVYSEESCENRLRKHGYPYGTG
                     RAMRRAAKDKAEQDVRERYIARYRQVE"
     gene            17396..17848
                     /locus_tag="IE290_RS04605"
                     /old_locus_tag="GCM10017786_09440"
     CDS             17396..17848
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423240.1"
                     /locus_tag="IE290_RS04605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09440"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_191243204.1"
                     /transl_table=11
                     /translation="MTAIDLGEDPLALDRQVCFALSVASRSVIGIYRPLLKPYGLTHPQ
                     YLVLLALWDRAPRSVKDLSETLRAEPATLSPLLKRLEALGYLTRERNRSDERALMVDLT
                     ESGRALRAEAEKIPYRVVETLGMEVAELEQLHAALARVIAATDRLG"
     gene            complement(17876..19579)
                     /locus_tag="IE290_RS04610"
                     /old_locus_tag="GCM10017786_09450"
     CDS             complement(17876..19579)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003084484.1"
                     /locus_tag="IE290_RS04610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09450"
                     /product="L-lactate permease"
                     /protein_id="WP_191243205.1"
                     /transl_table=11
                     /translation="MYRQVLDPVAGSLAWSSLVAAIPLLTLFVLLGILRMTAWLAALIS
                     LAVAVVVAIVVYPMPAGPAFLAASEGAAFGFFPILWIVINAIWIYNMTVATGHFDVLRR
                     SFARVSDDQRIQGVIIAFSFGALLEALAGFGTPVAITSVMLIALGFRPIKAAAVALVAN
                     TAPVAFGALAVPITTLATVTGLPLHDLSSMVGRQTPLLGVFVPLALVFIIDGRRGLRQT
                     WPAALVCGVVFALAQFATSNYVSAPLTDIVASLLSAGAVVAFLRVWHPAESYVEGSGVR
                     TTTAGAAAAAGTERAGGSTTTMERPPRPPAGGAGNGGERDRGVEVFRAYAPYLIIIAVF
                     ALAQIPAIKDALTSVTKTFNWPGLHIQSSSGKTSTLSQFKFDWLDAAGTLLIIAGLLTI
                     PVIGIRPARALRAYLSTYRQLATAIVTVMAVLALAYVMNASGQTATLGTWMAGAGGVFA
                     LISPVLGWLGVAVTGSDTSSNSLFGALQVVAANKAGLSATLLAAANSSGGVLGKMISPQ
                     NLAIAAAAVGMAGREGDLFRRVLVWSLVFVAVMCLLVYLQSTAVLGWMVP"
     gene            complement(19588..20913)
                     /locus_tag="IE290_RS04615"
                     /old_locus_tag="GCM10017786_09460"
     CDS             complement(19588..20913)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982779.1"
                     /locus_tag="IE290_RS04615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10017786_09460"
                     /product="(Fe-S)-binding protein"
                     /protein_id="WP_191243206.1"
                     /transl_table=11
                     /translation="MTGPAFDDHHPPSADLLDDCVHCGFCLPTCPTYQLWGEEMDSPRG
                     RIYLMGLGVEGEPMTPEMVQHFDACLGCMACVTACPSGVQYDKLIEATRAQVERRHPRS
                     RRDRLLRRAIFSVFPYPRRLHALRGPLRAYQASGLGGPVRRVLGRALPRLAALESLAPP
                     LGPFQRVPERIPARGTRRGTVGMVLGCVQREFFPGVNAATARVLAAEGFDVVAPAVQGC
                     CGALSVHNGREDEAQSFARKLIDAFDGSGADWIAVNAAGCGSAMKEYGDLLADDPAYAQ
                     RAREFTARVRDVSELLAEQGPVARRHPLPVTIAYHDACHLAHAQGIRAQPRRLLRDIPG
                     LTLREIPEPEICCGSAGIYNVLNPGAGGELGERKARNVLATGAPLLVTANPGCLMQVAA
                     ALDALGEPVRLAHTIEVLDASIRGLPADGVGWARSRRHAPHP"
ORIGIN
        1 ggcccggccc ccaccaccac gacgggcagc tcgctcatcc cgaccccttt catcgatcca
       61 gctcgattga gcaccgttcc gccagactct atcgaccggt gtcgattgaa gcaaccatcg
      121 attcgggtcg atacactcgt gggcatgacc acgactgtcg cgccccaggc ccaggtcctg
      181 ccggacgggg aagccgccac ctacgccgac tggttcgcct gcctggccga acccacccgg
      241 gtgcgactcc tgcacgccgt cgccaccgcg ccccgcggca tcaccgtcgg cgccctgacc
      301 gacctgctcg ggatcagcca gtccacctgc tcccaccacg tgcgcaaact cgccgacgtc
      361 gggttcgtgc aggtgcgcaa ggagggcacc gccaccatcg tcaccgtcaa cgcggcctgc
      421 tgcgccggcc ttccgcacgc cgccgacgcg gtcatggggc tgctcgcgcc gcgcccgtgc
      481 tgcccggaag acgtccccgc cgacgtcacc gtccgggccc tgcgcgacga cgactggccc
      541 gcggtccgcc gcatctacgg cgaaggcgtg gacaccggcg tcgccacgtt cgagaccacc
      601 gtccccagcc gcgccaccct cgacgcgaag tggatcgacg gacagcggtg ggtcgccgag
      661 atcgacggca ccgtggtcgg gtgggccgcc gccaccccgg tctcaacccg cgagtgctac
      721 tccggcgtcg ccgaaacctc gatctacgtc gcggacggcc accgcggccg gggtatcggc
      781 aaggccctca tccgccggca agtcatcgcc ctcgacgagg ccggctactg gaccctgcaa
      841 acctccatct tcaccgaaaa ccgcgccagc ctcgccctgc accactcagc cggctaccgc
      901 accatcggca tccgcgaacg catcgcccaa cgcgacggca cctggcacga caccgtcctc
      961 ctcgaacgcc gcaacaacat cagctaacag ccggccgccg gggacgagca acgcgttcga
     1021 ctacgcgaca gcgcgcggca cgatgcgggt gctgcagttg gcgcacgacc ggtggcggga
     1081 gatcgggcat gatcagccac aatgagtcat gccccagaag gagcggccga acgagcgcat
     1141 ggctcgggag atcgtcgctg acacgttgcg cgtccccgtg acctgtcacg acgacaacac
     1201 gcaaggctcg atggtggacg cgctgatcca ctacccggac ggcagcctgg gtgcgatgga
     1261 gatcgtcgcc gatcatgacg accgcttcaa caagatgtgg gacgctttgg agaaggcggg
     1321 ccactcgctt ccggtcggcg gtctgcgcag gagctggaac gtagtgctcg gccacgccgc
     1381 cgatcttcgc cgtgtgaggg ctgaactgcc ggacctcctc cgcggcatgg aggatctcga
     1441 gcattccgac ctccgccggg tgggccggaa gcggaacccc gaggtgaccg atcgagcggc
     1501 tgcgctcgga gtgcggatgg cctacgtcgt cgaccacacg cctccaggaa cagtgcatct
     1561 tcgcgccgaa gggtggtcag ggttcatcga aacggtctcg ctcgccaact gggtgcgcga
     1621 tgtcctggca aggcacccgg gcaagcagaa caagctcctt gcgcatgacg gggcccgcga
     1681 acggcacatc ttcatctggg cgaccatggg cagcaacttt tcgatccagg acctgctgat
     1741 gcggcgcgag caggcagcga tcgcagagca ggcggctccg aaccttcctg agggaatcag
     1801 ccacgtgtgg gtcgccggtt cgatgtcctc tcagggggtc gcgggctggt cggctgatcg
     1861 tgggtggtgg tggacgccct ggcggttccc tcggcgcgtt gacgacgctg agtgacgccg
     1921 cgtccttcac tgcctgatga tcatcgttgt tggaggtgct gccgggcacc ctcggggagc
     1981 aggtcgggag cagcacggtg agttgggacg gccccaaccg tcgagcaggg gcgcgaaggt
     2041 ggggccgcgg atattccgct tgggccgctg cgccgagcat gcacgttctg cgagtgtcat
     2101 gattggccat tggtgtgagt tggccgggtg aagttccggg ctagatgtcc cctcagcgcc
     2161 ttgaatccgg agttccaggg tgtcgcgatt ctgtctacac tccggaggtc ttcggatgtc
     2221 ttcgtctctt cctggttcgc tgtaccaccg cttgactatt gcgcattttg gagcgtggat
     2281 acatgcgtgc ggaatgtggt cagatgttca gtcgtgttct ggatcgggcc ggccggtggc
     2341 gggattcgag cgccgtcgtc tggtatccac ggttggcctt tccggctgtg gaaaagttgg
     2401 cagcttcggc cggcagtcgc gggtttcgca ttgagtggcc acgagcggga gcgcctgcac
     2461 gtcgatgtgg atgtgcgttt gccatccgat tgtccagagc tgacgcacgg cgctgcgcgg
     2521 gggatgttgc gtctgctgtg caaggctgct gacgtcagta cggacgacca atcggatggc
     2581 gcagagtccg ggcgaggaga aattgggcag ttcgggaggg cggcgtagtg gtcaggtttg
     2641 ccttctacgg gcgggtgtcg actgaggatc agcaggatcc ggaggcttct cggaactggc
     2701 agcgggctcg tgcacaggcg ttgatcgacc ggcacggaaa gctggtggcg gagttcttcg
     2761 atatcgggca gtcgcggtcg attccgtgga agcgtcgccc ggaggcggcg cgcctgctgg
     2821 aggctatgcg tgatccggac cggggtttcg atgctgtggt gatcggcgag ccgcagcgtg
     2881 cgttctatgg caaccagtac ggactgacgt tcccggtgtt cgttcactac ggggtcgagc
     2941 tctgggtgcc ggaggttggc ggggcggtcg atcccgagtc cgaggcgcat gatcttgtga
     3001 tgtcggtgtt cggtgggatg agcaaggggg agcgcaatcg catcaagatc cgggtgcggt
     3061 cggcgatggc ggcgcaggcg agcgtggagg gccgtttcct ggggggacgc ccgccgtacg
     3121 ggtaccggtt ggcggatgcc ggtccgcacc ctaatccggc gaaggccgct gagggtaagc
     3181 ggctgcgccg gttggagccg gatccggtta cggctccggt ggtgcagcgg atctatcgcg
     3241 agtacctggg tgggcggggg atgtttgcga tcgcggaggg cttgacgcgt gacgatgtgc
     3301 cttcgccgtc agcccacgat cgagcacgca atcggcatcg gtcgggcatc gcgtggtcga
     3361 agggtgcggt gcgggtgatc ctgtcgaacc cgcgctatac cggtcgtcag gtgtggaaca
     3421 agcagcgcaa ggacgaggtc ctgatcgacg tcgaggacgt cgcgttgggt cacgagacgc
     3481 ggatgcggtg gaacgcgagg gacaaatgga tcttgtcgga tgaccttgtg catgaggcgc
     3541 tgatcgatgc ggagacgttc gagcgggcgc agcaggttct tggggccagg ggagcgggcc
     3601 gcacgacgcg ggagcggcag cgcacgcgcc accggtacgt cctgcgcggg ttggtgcggt
     3661 gcggattgtg cggtcggcgc atgcaggggc agcagagccg ggaagtgttg ttctaccggt
     3721 gccggtttcc cgctgagtac ggtttggcga acaaggtgga gcatccgcgc aacgtctatc
     3781 tcgccgagcg tgacctgctc ggaccgctcg atgcgtggct cgcgaagtcc ttcgcgccgc
     3841 atcggctcaa agacacggtc gacacgctgt atgaagccca ggccgcggac gatgacgaac
     3901 acgcagcttt ggcggctatg cgggtcgtcg aggagtgcga ccaggcgctc cggcgtcacc
     3961 gagccgcgct ggaagcgggg gccgaccccc aactggtcac tcggtggatg gccgagactc
     4021 aagcacgccg cgccgaaaca ctcgccaagg cgcggccggc tgctcggccg cagcggctga
     4081 gcaaggacga gatccagggc ctgatcgaca gtctgggcga cctccggcgc accctgatcc
     4141 acgccgcgcc cgaagacaag gcagccgtct accagcagct cggcctgcag atgatctacc
     4201 accccggtaa acgaactgtg cgggtcgaga cgaatctcga cccgcacagt tggggttatg
     4261 gaacgtgtcc gaggggggac ttgaaccccc acgcccttta cgggcactag cacctcaagc
     4321 tagcgcgtct gccattccgc cactcggact tgctcttctc ttgtgcgcac aagagtagcc
     4381 catccacgga ggctcggtga cggggggtgg gtcaccgcgg gtgatcaaca gtgcgctata
     4441 agcccgggcg gtcacacagg gtgagccagt aggctgcccg gtgggactcg agaaggagca
     4501 ggtcggtgcc ggggtggctc acgggtgtgc tcatcgccgc cggggtggtt ctcgcctcct
     4561 gggtgcttct catcctgctc gcccggctgc tgccgccggg gctggcccgc gatctcgccc
     4621 gcttcctgcc ggactgtgtg atcaccgtca aacggctccg cacggatccc cgcgtgccgc
     4681 gcggcgccaa gctcgccgtc gtcttcgcgg ggttgtgggt gctctcgccg gtcgacctga
     4741 tccccgagtt cctgccggtc atcgggccgc tcgacgacgt cgtggtcgtg gcgctggccc
     4801 tgcggtacgc cgcgcggcgg gtgccgcccg acgtgctcca cgacgcctgg cccggcaacc
     4861 ccggcctgct ggaccggctc atcgggcgtc gtggcgaaaa atcgccggac accgatacgt
     4921 cgggcgcata acgtccgggg cgtggatctc agcatggacc gccgcgcgat ggtcgcggcc
     4981 ctgaccaccg tcgtcctctg ggcgtcggct ttcgtggcca tccgggcggc gggggagtac
     5041 ttcgcgccgg gcgcgctcgc cctgggcagg ctcgccgccg gcaccctcac cctcctcgtc
     5101 ttcctgctca tccgccgcga gggcctgccc aagcgcgagg cgtggccggg catcgccggc
     5161 gcgggggtgc tctggttcgg cgcctacatg gtcgtcctga actggggtga acagctcgtc
     5221 gacgcgggca cggcggcgat gctggtcaac gtcggcccga tcctgatcgc cctgctcggc
     5281 ggctggctgc tgcgcgaggg cttccccggc cggctgctcg cgggcctggc cgtgtcgttc
     5341 gccggcgccg tcgtcgtggg gctgtcgatg tccggccgcg ggcacgcccc ggtgctcggc
     5401 gtggtgctgt gcctgctcgc cgccatcacc tacgcgggtg gcgtggtgag ccagaagccg
     5461 gccctcaagc acgcctcggc gctgcaggtg accacgttcg gctgcctcat cggcaccgtc
     5521 gcctgcctgc cgttcaccgg gcagctcctc gacggcctcg cgaccgcccc cgccggggcc
     5581 accctgagca tgctctacct cggcgtcttc ccgaccgctc tggcgttcac cacctgggcg
     5641 tacgcgctgg cccgcaccac cgccgggaag atggggtcga ccacctacgc cgtccccgcg
     5701 gtcgtggtgc tgatggcctg ggccgtgctc ggcgaggtgc cgggctggct gtcgctggcg
     5761 ggtggcgtgc tgtgcctggc cggggtggcg gtgtcgcgca cgcgccggaa acgcgaacca
     5821 gtgctcactt agcaacggtt gtgaaacggt ttgttctggg tatccgtgcc ccatgaccga
     5881 cgcccgtctc gacgacgacc accccgaggc cgaccggtac gaccgcgcga ccgtcgaggc
     5941 ggtcggcaag ctcaccgagg ccctggagac cctggaggtc gcccgcgggc acctctacca
     6001 gttccaccgc atgaccggca ccaccgactt cgccgtcggc gaggccgtgg agctgctgcg
     6061 caaggccggc cacgacgagc tggccgaccg catcgcccgc gagctggtgg gccgcaacgt
     6121 gctgccgggg cggtggacgt tccaggtggt cgaggacttc gacgacacct actaccagcc
     6181 gttccgcgcg ttcgagcggc aggcgcggga gctgaccggc ggtcggcggc acctgttcga
     6241 ggccgagctg aagcgggaac ggcgcacgcg cggggtggcc gggcacgaag cgaccccgga
     6301 cgagcgggtg gggtgacgtg cagacgttcc tgcccttccc cgggttcgcc gacaccgcgc
     6361 gggtgctcga cgcgcgccgc ctgggcaagc agcgcgtcga gacgctgcag gtgctgcggg
     6421 cgctgacggt gccgaactac gggtggcggc accacccggc ggcgaagatg tggaccggct
     6481 acgaggaggt gctcacccgc tacggcctgg aggtgtgccg ggtgtggtgc gcggccgggc
     6541 gcaccgacac gtgcgcgacc aaactgaccg acgacctggc ccgcgcgatc ggcgtcaccg
     6601 agccccgcga cgagcaggcg ctgcgggagg cgggggagat gccgccctgg ctcggcgacc
     6661 cggagttcca ccgcagccac cagtcggcgc tgctgcacaa ggatccggag cactaccggc
     6721 ggttcttcga cggcgtcccg gacgatctgc cctacgtgtg gccggcctcg gaccggccct
     6781 cgcggctggt ccactcctga ccgcggagcc ggtagcggcg ctcggcgtag gcgaggtcgt
     6841 ccttccacaa ccgggcggcc gcgcggcgca tcaggggccg cagcgcgggg gcggcggccc
     6901 gcgcgacccg gaagcccggg cgctccgagg cggccaccac ggcttcgatg accgcggtcc
     6961 gcggacggcc gtcacgaccg ggacccagtg gcgtggcgtg ggtttccacc acgctgccga
     7021 cgccctcccc gtcggtgatg cgcatgacga tcgtccgcgg cccggggcag gtgaactccg
     7081 cctcgaccgg cacccccagc gtcggcgtga cgcggaaggt caccgacacc acgaaccggt
     7141 cgtcggactc ggccacgtcg acctcggccg gcgccgacag gaccttcagg cgcgtgaacg
     7201 agtaggggtg gaaccacgag ccgtgccacg ggtcgagccg gttggcgatg atgtcccgcg
     7261 gctcgcacac cccctccagg cgcgccaccg agtccacgcc cccggccggc cgggccggga
     7321 cgatgggtga cggcaacggc tcctcgccgc cgacgtggtc cagccgcacc cacgccagca
     7381 ccccgtcgtc gaaggcgggg cggcacgaac gctcgtccag acgcaggccg tgccaccggc
     7441 agcgcaggcc gccgtcgtcg acccggccga gcgccatcgg ggcgcccagg tgcgggcacg
     7501 ccccgggccc gaccagcagt ttcccggccc ggtcccgcca cgcgaccagc tcgatctcgg
     7561 ccaccgagaa cccgtacggc cggtccccgc gcacatcccg gctggcggcg aacacgtacc
     7621 agttccccga cggccgcgcc tcggcccgtt tgagcgcggc ctcgatcagc gacggcttcg
     7681 cctcccggta ggtgggctcc tgacgcgccc acggcgtgcg cgggatcggt tgcagcggcc
     7741 actcccgggg ccacttccgg gaccaacgcg gtgccatcct caccctccca gcgcggccag
     7801 ggcccgcagc ggcgcgaacc gcccgcggac cggcacggtg gtcagttcgt gcccggccag
     7861 cccccaccgc gcgagcaggc agttcgcggc gtgccagccg gtcgcggccg cgcgctccat
     7921 cagcgcgacc ggaagatcga tgcggatccc gtcgccggcc agcacgaccc cgtcgaacgg
     7981 ggtgcgcaca cgggggcggc gggcgaagtc gccgacgccg aacagcgggc agtcgcgccg
     8041 ccactggacc agctcgccga cgacccgcgc gcccgcggtc tccgggtaga gctggtgcag
     8101 ccggtccacc agctggttgc gcagcaccgt gacctcgtcg gcacaggcgt aggcgtgcag
     8161 ttcgacgacg gaaccgccgt gccgcgccgc ccacgacgcg gcctcgcgtt cgtagcggtt
     8221 caggacgctg atgttgtcca gcggatcgag cccgccggtg gcgaggaacg cgggccggtc
     8281 cggggcgacc gggcggtcca gccacagccg gtgcaccagg aacggcggcg cgatccgcag
     8341 cctgagcacc cgcgagcgcc actcgtcgtc ggccagatcg ggcgaggccg acacgatcga
     8401 ctgcagcccg gcgacgtcgg cggcgagcac gaccccgtcg gccgcgacac cgtcgaccgc
     8461 ccaccgcgaa ccgtcccgct ccaggccgcc cacctcggtg ccggtgcgga accgcacgcc
     8521 cagccccgcc aggtacgccc gcagcggctc ccacagcgcc gtgtcgtagg ccgagtccgg
     8581 cacgtcgaac accaggccct cggacgatcc gaggaagtac aggtggaaca tcgtcgccag
     8641 ctcggcggcc gacatccgcg acggcggcgc gaagaagctc cgggagaaca cctcgaacgc
     8701 caggtgccgg gcggccggcg ggaagttgat gtgctccagg aacgtcgccg cgtccacgtc
     8761 gtcgagccgc tcgtaggtgc cgggcaccga caccgcggcc agcggcgccg cggcgcgcgc
     8821 gttgagccgg aacagatccg cgagccgaaa ggtggggctg cgcagcgcga aggcgagcgc
     8881 gttccacggc ggtgtgcggg gcaggccgcg gaaggtgtcc cggcggccct cggcgtcgac
     8941 gagcgggtag tcgtcgaccg gccgcagccg cgccaggtcc gggtcggtgc gccgcagcag
     9001 ggcccgcagg ttgtagtact gccggaagaa cgcgtgaaaa ccccggctca tcgacacggt
     9061 gctgccgtcg gcgagccggt cggtccaggc ggacacgcgt ccacccagct cgttctcccg
     9121 ctcgacgacg gtgaccgcga cgccgcgctc ggccagcccg gtggccgcgg tgagcccggc
     9181 gatcccgccg cccaccacga cgaccgaacg gggaaccccg ggggacagcg cgccggcggg
     9241 ggcgcggtgc cggacggcgc ggcggtcggt cacgcggtct cctcggggtt ggtggccagg
     9301 aaggtgtgca cgacgccgcg ctgccagccg gtcatcgtct cgctgtgcac cgcggtgaac
     9361 ccggcctcgg ccagccgctg ccggaaccgc gcggcaccgt cgaaggacag gacactgcgc
     9421 cacaggtgcc ggtagagcgt cgcgtcgccg gtcgccagcc gtccggcggg gatgatgatg
     9481 ctccagcaca ccgcgtgcca cacggcgcgc gccaccggcg aatcccgcac ggagtactcg
     9541 tgggcggcga aggtgccgcc cggcttcagc aacgcccgca acgcacgcag ctgcccgtcc
     9601 gggtcggcga ggttgcggat caggtacgcc gcgaagatcg cgtcgaacgg cccggcgatc
     9661 ccggaggagg ccaggtcttc gacgtggctg tggacgaagt ggacggtcgg gggccaggac
     9721 ttccgccgcg cctgggcgag catctccgcg gaggcgtcga aggcgacgat ctcggcgcgc
     9781 ggcgcggcgg ccagcagcgc ggcggtggag gcgccggtgc cgcagcccgc gtcgagcagc
     9841 ctcaggccgc ggcccccgcc gggcaggcgc atccggcgcg ccgacagccg caggtgctcg
     9901 tggtacccgg ggttcgcgcc gaccagccgg tcgtaggcgg cggcgccggt gtcgaacgcg
     9961 ccgggcacct cgtgccgggc caggccggtg cggtccgggc tcatgcgtcc tcctgcctgg
    10021 ccgtgcgccg ttcccacagc agcagcacgg cggtgaccag cgcgaacccg aacaggaagt
    10081 cctcgaccgg gatgtcccac gggaagcgca ggccgctggt gtgctcgggc gcgtagagca
    10141 cgatcggcgc gctcagcttg gtgagccagc cgtcgaccgg gatctggaac ccgaccacga
    10201 tcgccatcga gatccagtac gcgggcttgc cgaacaaccc ggtgcgcagg tatgccagct
    10261 cccacccgca cacggcgagc accgcgagca cggcgggcag cgtgtacccc agcccggtca
    10321 ccggcgcacc ttccgcagcg tgcgcagccg gccgagcatc gcctgcacac atccgtaggt
    10381 cagcaccccg cacaccggga tgaccaggaa gaacatcagc tcctcgagcg ggatcgcgaa
    10441 cggcagccgc accccggtga cgtaggcggg gttgtaccac cacacgccgc cggcgatcgc
    10501 gatcgcgtcc cagaccagga acaccagcgc caccggcagc accgcgcgcg ccagggccac
    10561 cgggcgccgg tagacgcggg cgcccaggaa ctccaggggc agggtgatcg ccaggcaccc
    10621 ggccaggacg agcaggtact ggtaacggtc cattcacgcc cacctttccg tcgcggcccc
    10681 ggtcagatcc gccgcacgcc ggccccgccg cgcccacatc gcccgcgcca gcccggtgac
    10741 cgccagccgc gcccggcggc cgcggccgac ccgggcccgg tgggcgaaca ccgcgaaccc
    10801 ggccgcctcg atccggtcca ggatctccga gtacagcacc agcgcggtcg cgatgcacgg
    10861 ccgggacacc gggtgcagcc ggtcgatccc ggcgcgggcg taggcgtaga tctcccgggt
    10921 ggcggcgtgc tgggcggcca gcgccgcgcg caccttcggg tcggtgcgcc cgtggcggcg
    10981 gcaccacagc agcaggtcgc ggtcgacgcc gaacgcggcg agctcgtcgg cgggcaggta
    11041 aacccggccg cggtcgaggt cctcggcgac gtcgcgcagg aagttggtca gctggaacgc
    11101 cttgcccagc gccgccgcgt acggcgcggc ttccccgggt tcgccgacgg tgcccagcac
    11161 gggcagcatc tgcagcccga tcacctcggc ggatccgtac acgtaccggt ccagggcggc
    11221 gcggtcggcg taaccggtga cggtgaggtc catccgcatc gagtcgagga acgcggcgaa
    11281 cagatcgcgc cggatgccgt agcgcgcggc ggtgtccacc accgcggcca ggatcgggtc
    11341 gtcgctgtgg ccgcgttcca gtccggcgaa caggtcggcg gaaagcgctt ccagccgcgt
    11401 ggccgggtcg gtgcccgggg cggcggtgtc gacgatgtcg tcggcgaagc gggcgaaccc
    11461 gtagagcgcg tgcacggccg ggcgctgcgc cttggtgagc aggcgggtgg ccaggtagta
    11521 ggtgcggccg tgttcggcgt tgaggcggcg gcagcggacg taggccgcgc gcaggcgcgg
    11581 ttcggtgatc ccggcggcgt ccagggcccc ggtcatggcg ccgccaccag cggacgggtc
    11641 acgcgggcgc cggtgatccg gtcggcggcc agccgcccgg acaccagcgc ggtcggcacc
    11701 cccaccccgg gcgcggtgct gccgccggcc agcaccacgt tctcggtgcc gcgcaccagg
    11761 ttgcgcgggc ggaacgggcc ggtctgcgcg acggtgtgcg ccagcgcgaa cggggtgccg
    11821 gccagcatgc cctgccgggc ccagtcggcc ggggtgacga cgtgccgggc ctcgatgctg
    11881 ccgtccagtc cgggcagcag ccgctcggcg acgtgcccga ggatctcgtc ggcgtaggcg
    11941 tcgccgacgc ggtcccagtc caccggcccg cgccgcaggt tgggcgcggg cgcgagcacg
    12001 tagagcaggt cgcgcccgtc cggggcgagc gcggggtcgg tggccgtcgg ccgggtcacc
    12061 agcagggagg ggtcgctcat cagccgtcct tgcgagatca gctcgtggaa cgtccgccgc
    12121 cacgccgcgc cgaacaggat ggtgtggtgc gcggtgtcgc accgctgccg cgtgccgacg
    12181 tgcacgacga ccgcggacgg ggccggccgc agcggcaccg gccggcgcgg ggtccggccg
    12241 agcagcgcgt aggcggccgg cagttcggtg gtgagcacga cggcgtcggc gggcaggctg
    12301 ccgccggtgg tctcgaccgc ggtcacccgc gcgccggacc gcgccagcgc ggtgacctcg
    12361 gtgccgtagc ggaactccac cccggcgtcc gcggcggccg cggccagggc gtcgggcagg
    12421 gcacgcagcc cgccgcgcgg gaagaacacc ccggcgacgg tgtccatgta ggcgatcacc
    12481 gcgtacacgg ccagcgcgtg ctggggcgac tgcccggcgt agagcgactg gaaggagaac
    12541 acccggcgca gccgctcgtc gcgcaggaac cggccgatct tgcggtccag cgggccgaac
    12601 gcgcccatcg cgaccaggcg ggccaggtgc ggcgtgacca gcgccagcgg cgagtcgaag
    12661 ttggcggcga tgaaccggtc gaactcggtg cggtacaggc gggtgagcca ttcgcgcagg
    12721 cgccggtagc cgtccgcttc ggacggtccg gcgaaggagc gcaccgcctc ggccatcgcc
    12781 tcggggtcgc tgtgcacgtc gaggctgctg ccgtcggcga agcgggcgcg gtaggcgggt
    12841 gtgaccggga cgaggtccag gcggtcggcc aggctgtcgc cgacagcggc gagcgtctcg
    12901 tcgacgagat cgggcatggt cagcaccgtg gggccggtgt cgatccggta gccgtccagg
    12961 tccaggcgcc cggtccggcc gccgggcacc ggctcgcgct ccacgacggt gacctgccgt
    13021 ccgcgcccgg ccaggtgcag cgcggccgcc agcccggaca gccccgcccc caccacgacg
    13081 atccgctccg ccgggcccgt cacggtccgc atccgcccac ccctcactcg gccactcgcg
    13141 ggccaaccgt tgcacgaacg ttgcgctgtt gtccactcgg tgagcccgcc acgctgcgga
    13201 ctagcgtagg tgacgcacgg ggagacgacc ggatgcgagg aggacgcggt gggagacctg
    13261 ctgggccacg ggtcggcacc gaggaagcgg ctgcgggagc tgctggccgc gcccggaccg
    13321 ctggtggcgc ccggcgccta cgacgcgctg accgcccgcc tgatcgagca ggccgggttc
    13381 gacgtggtct acatgaccgg gttcggcacc accgcgtcgc tgatcggacg gcccgacgtc
    13441 ggcctgctga ccggcacgga gatggtggac aacgcccggc ggatcgtcgc cgcggtggac
    13501 gtgccggtga tcgccgacgc cgataccggc tacggcaacg ccctcaacgt ggtgcgcacc
    13561 gtgcaggcct acgagcaggc cggggtcgcg ggcatccacc tggaggacca ggtcagcccc
    13621 aagaagtgcg ggcacctgtc cggcaaggcc gtcatcccgc gcgaggagat ggtgggcaag
    13681 ctgcgggcgg cggtggcggc ccggcgggac ccggacttcg tgctgatcgc ccgcaccgac
    13741 gccgcggccg tgcacgggct cgccgacgcg atcgaccggg cccgcgccta cgccgaggcc
    13801 ggggcggacc tgctgttcgt ggaggcgccg accagcgagg ccgacctcgc caccgtcgcg
    13861 cgggagctgt ccggggtggc cccgctggtc ttcaactggg ccgagggcgg ccgcaccccg
    13921 ccgctgtccc tgcagcggat ccgcgagctg ggcttctcgc tcgtgctcta cccgatcggc
    13981 acgctgctgg ccgcgaccgc gggcgtgcgc gcgctgctgg acaccgtgcg ccgcgacggg
    14041 acgcccgcgg ccgcgctgcc cgggctgccc ttgttcggcg agttcaccga cctcatcggg
    14101 ctgcccgagg tgtccgatct ggaggcgcgg ttcgccgggg agtccggtta ggacacctgc
    14161 ggcacgccct tgacgaactc caggttcatg ccgaacaggc cgcgcgcgac gcgctggccg
    14221 cccagccagc cgtggaagta gatccgccca ccgacgatgt ccgccccgcc cggtccttcg
    14281 gcggcgtggc cgatcgagtc cgtggtcagc agcggctggt cggccttggt gtaggggccg
    14341 gtcagcgcgg gcgccgtggc gtagcgggtc tggtagccgg cgttgcggaa gtcgtcggcg
    14401 gagtagaaca gcacgtactg gccgccgcgc tgggtgatca ccggcgcctc gacgatgccc
    14461 ttctcctccg gacggtccgc gcgcaggatc tcggtgcgcg ggccggcggg cgcggtgccg
    14521 tcctgggtca tcttctgcac gaagatcgcc gaggcgccgc cgcccgggtg ctcgcccttg
    14581 tagagcaggt agcgggtgcc gtcgcgggtc tggaaggtct gcggatcgat gtcgccccgg
    14641 tcgccggggt cgcagatcag cggcgcgtcg ccggtgggct ggtaggggcc ggccaccgag
    14701 tttcccacgg cggcgccgat gcagcggtgc ccgtccgctt tggacaccgc cgagtagtac
    14761 atcaggaacg tgccgtcggc gcggcgggtg acgtccggcg cccagtagcc gcccttcggg
    14821 tccacccagg acggatccgc ggcgagcgcg tcgccggtga cctgccacgg cccgtcggcg
    14881 tccttggcga cggcgacggg gatccggccg gacgggccgg tggtggcgaa ggcgtggtag
    14941 tcggtgccga tcttgagcac gtcggggtcc gggaagtcct ggtcgagcag cacgcgcggg
    15001 gcgggcgcgg cttgcgccac ggcgcccggc agcagtgccg aggagagcag gattcccagg
    15061 caagtcaacg ctctcagggt cttcgggcgc cgtcgcgggc ggggcgggtc gtcgggttcg
    15121 cgggctcggg tgatcttgcc tgccgtagtc acggcgcagg agttacccgt ggcgcggcgg
    15181 gactaatctc ctcccttcgg gccgcgtatc gtgcccggtg tggtgatgac gggggagtcg
    15241 cggacactgg gcctggtgat ccacccgacc aggtcggtgg agtcgtcggt gcggacggtc
    15301 accgagcacg cgtggacgcg cggcgtcgag gtgatcgtgc gcgaggcgga cgccgcgcgc
    15361 gtgcccggcg tggcggcggt gtccgaagcg gacttcgtgg cgcgggtggg cgcggtgctc
    15421 agcctcggtg gcgacgggac gatgctcggc gcgatgcggc tggtgatggc gcggccggtg
    15481 ccggtgctcg gcgtcaacca cgggcacctg ggttttctgg tggagatcgc gccggagcag
    15541 ctgccggacg cgctggaccg gctggtgcgc ggcgagtaca cgatcgaacc gcacagctgc
    15601 ctggtggcgt cggcaggcga ggcggtgctg gccgggttca acgacgtggt gctggcacgg
    15661 gccgggcggg ccggcgcggt gtcggtggat ctggtggtca acggccgcca gtacggctac
    15721 tacaagtgcg acgcgctgat cctggccacc ccgaccgggt cgacggccta caactacgcg
    15781 gcgggcgggc cggtgctgtc gccctcggcc gaggcgatcg ccgtgacccc ggtggcgccg
    15841 atggccggca tcagccgccc gatcgtgctc ggcccgcagg acgagatccg gctgcacgtc
    15901 gcgccggaca gcgccccggt ggcggtggag gtcgacggca ccgcggcggg agcgctgggg
    15961 ccggacgcgg tgctgacgac ggtcctgcgc ccggaggccg cgcaggtggt ccgcctggcg
    16021 gccggcgagc acgcgagccg cagccgggtg aagctgagcc tgctcgacct gccgctgcgg
    16081 ccggaccagc tgctggagct gatcccggaa cacctgcgcc gccgcctgga cccctgaccc
    16141 cgcgccccac actcccgcgc gcgttccacg ctgggggcgg tgagttccgc gttcgcggct
    16201 gcggccgggc ggcgggctgt ccggtggacg gcgtgcgaac gcaggactcg cgggtgtcgg
    16261 tgtgggggtc gcgctggggt ggcggtgggc ggcggacccg cctaccgtgg cttgccgggg
    16321 ccgcggaaag gggaaccggt atggccgtgc accagccctc gggggcgttc cgggtcagtt
    16381 tcggcgaggg catggcccgc gagctgcggc gggtgaccgg ccggtggtgg atggtcgcgc
    16441 ttctcggcgt cgccaccctg gtgctcgggg tgctcctgct ggccaacctc gcgaccgcgg
    16501 tcggcacgct cgccgtcctc gtcgcgcttg cgctgctgtt cgaggggttc gacgagatcc
    16561 tcaccgccga gcggcaccgc acccgctggc cgtcctacct gctggggctc gtgtggatcg
    16621 ccgtcggggt gatcgccctg gcctggcccg gcatcacgct gctgacgctg gccgtggtgg
    16681 tcggggcggg gttcgtcctc gccggggtcg gccagatcgc ggcgtcggtg gcgtggcggg
    16741 ctcggctgcc gatgtggggg ctgtggctcg gcctgggtgt cgtgaccctg ctgatcgggc
    16801 tggtcgccct cgtgtggccg gacctgacga tcctcacgct ggccatctgg ctcggcctcg
    16861 ccctggtgat gcgcggcctg ggcgccctgt ggttcgggct gcagctgcgc cgcgcgcacc
    16921 gcgcggtcga agcctgactc actccacctg gcggtaccgc gcgatgtagc gctcccgcac
    16981 gtcctgctcg gccttgtcct tcgccgcgcg ccgcatcgcg cggccggtgc cgtacgggta
    17041 gccgtgcttg cggaggcggt tctcgcagct ctcctcggag tagaccagcg agtagaagaa
    17101 cccgacgagc ccggccatca gcaccaggct cagccgcagc gtcagcgggc cgggcagcag
    17161 cagccacacc agcatcaggg gcagcagcag caccgcggcg cgggccgcgt gccgccagat
    17221 ccaggtcttc gcggtcacgt cgtgcaggac ccactcccgg tgctcctccg gcaggcggcc
    17281 gccgagggcg taccagagcc actggatcgg gttggggcgt cggcgctcgg tcaccggtcc
    17341 acagtaccct aatgattagt gcgttaaata tcagcgcgag gagtagtctc accccatgac
    17401 cgcgatcgac ctcggcgagg acccgctggc cctggaccgg caggtgtgct tcgccctgtc
    17461 cgtggcctcc cgcagcgtca tcgggatcta ccgcccgctg ctcaagccct acgggctcac
    17521 ccacccgcag tacctcgtgc tgctcgcgct gtgggaccgc gcgccccggt cggtgaagga
    17581 cctctccgag acgttgcgcg cggagcccgc cacgctgtcg ccgctgctca agcggctgga
    17641 ggcgctcggg tacctgaccc gcgagcgcaa ccggtcggac gagcgggcgc tgatggtcga
    17701 cctcaccgag tccggccgcg ccctgcgcgc cgaggccgag aagatcccgt accgggtcgt
    17761 ggagacactc ggtatggagg tcgccgagct cgaacagctg cacgccgcgc tcgcgcgcgt
    17821 gatcgcggcg accgaccggc tcggctgaac cggcgcacct cggccgcgag tcgtctcagg
    17881 gcaccatcca gccgagcacc gccgtggact gcaggtacac gagcaaacac atcaccgcga
    17941 cgaacaccag gctccagacc agcacccggc ggaacaggtc gccctcgcgg ccggccatcc
    18001 cgaccgccgc ggccgcgatc gcgaggttct gcgggctgat catcttgccg agcaccccgc
    18061 cggaggagtt cgcggcggcc agcagcgtgg ccgacagccc ggccttgttg gccgcgacca
    18121 cctgcaacgc tccgaacagc gagttcgacg aggtgtccga accggtcacg gcgacaccca
    18181 gccagccgag gaccggcgag atcagcgcga agaccccgcc cgcgccggcc atccaggtgc
    18241 ccagggtcgc ggtctggccg ctcgcgttca tcacgtaggc cagggcgagc acggccatca
    18301 cggtgacgat cgccgtcgcc agctgccggt aggtggacag gtacgcgcgc agtgcgcggg
    18361 ccggccggat gccgatcacc gggatggtga gcaacccggc gatgatcagc agcgtgccgg
    18421 cggcgtccag ccagtcgaac ttgaactgcg acagcgtcga ggtcttccca ctggaggact
    18481 ggatgtgcag gccgggccag ttgaacgtct tcgtcacgct cgtcagggcg tccttgatcg
    18541 ccgggatctg cgcgagcgcg aacaccgcga tgatgatcag gtacggcgcg taggcgcgga
    18601 agacctcgac cccgcggtcc cgctcaccgc cgttcccggc tccgccggcg ggcggccgcg
    18661 gtgggcgctc catggtggtg gtggacccgc cggcccgctc ggtgcccgcc gccgcggccg
    18721 cgccggcggt ggtcgtccgg accccgctgc cttccacata ggactcggcc gggtgccaca
    18781 cgcgcaggaa cgccaccacc gcgccggcgg acagcagcga ggcgacgatg tcggtcagcg
    18841 gtgcgctgac gtagttggag gtggcgaact gggcgagtgc gaacaccacg ccgcacacca
    18901 gcgcggccgg ccaggtctgg cgcaggccgc gcctgccgtc gatgatgaac accagcgcga
    18961 gcggcacgaa cacgccgagc agcggggtct ggcgcccgac catcgaggac aggtcgtgca
    19021 gcggcaggcc ggtcacggtc gccagcgtgg tgatcggcac ggccagcgcc ccgaaggcca
    19081 ccggcgcggt gttggcgacc agggcgacgg cggcggcctt gatcggccgg aaacccagcg
    19141 cgatcagcat gacgctggtg atcgccaccg gggtgccgaa cccggcgagc gcctccagca
    19201 gcgcgccgaa ggagaacgcg atgatgacac cctggatccg ctggtcgtcg ctgacgcggg
    19261 cgaacgagcg ccgcagcacg tcgaagtgcc cggtcgccac cgtcatgttg tagatccaga
    19321 tcgcgttgat cacgatccac aggatcggga agaacccgaa cgccgcgccc tcggacgcgg
    19381 cgaggaacgc gggcccggcg ggcatcgggt agaccacgat cgcgaccacc acggcgaccg
    19441 ccagcgagat cagcgcggcc agccacgcgg tcatgcgcag gatgccgagc agcacgaaca
    19501 gcgtgagcag cgggatcgcc gcgacgagcg acgaccacgc gagcgacccg gcgaccgggt
    19561 cgagaacctg ccggtacatc gatcacctca cggatgtgga gcgtgccggc gcgaacgcgc
    19621 ccacccgacc ccgtcggccg ggagtccccg gatcgaggcg tcgagcacct cgatcgtgtg
    19681 ggcgagccgc acgggctcgc cgagagcgtc gagcgcggcg gccacctgca tcaggcaccc
    19741 cgggttggcg gtgaccagca gcggcgcgcc ggtggcgagc acgttgcgcg ccttgcgttc
    19801 gccgagttca cccccggctc ccgggttgag gacgttgtag atccccgcgg agccgcagca
    19861 gatctcgggt tcggggatct cgcgcaacgt caggccgggg atgtcgcgca gcaaccggcg
    19921 tggctgcgcg cggatcccct gggcgtgcgc gaggtggcag gcgtcgtggt aggcgatggt
    19981 gaccgggagg gggtgccgcc gcgccaccgg tccctgctcg gcgagcagtt cggacacgtc
    20041 ccggacgcgg gcggtgaact cacgcgctcg ctgcgcgtag gcggggtcgt cggcgagcag
    20101 gtcgccgtac tccttcatcg ccgaaccgca cccggcggcg ttgaccgcga tccagtcggc
    20161 gccggagccg tcgaaggcgt cgatcagctt gcgggcgaag gactgcgcct cgtcctcgcg
    20221 tccgttgtgg acactgagcg cgccgcagca cccctggacg gcaggcgcga cgacgtcgaa
    20281 accctcggcg gcgagcacgc gcgcggtggc cgcgttgacg ccggggaaga actcgcgctg
    20341 cacgcacccg agcaccatgc ccacggtgcc ccgccgcgtg ccgcgggcgg ggatccgttc
    20401 cgggacgcgc tggaacggcc ccagcggagg ggcgagcgat tccagcgcgg ccagtcgggg
    20461 cagggcgcgg cccagcacgc ggcggaccgg gccgccgagg ccgctggcct ggtaggcccg
    20521 caacggcccg cgcagggcgt gcagccgccg cgggtagggg aagacgctga agatcgcgcg
    20581 gcgcagcagg cggtcgcgcc gcgagcgcgg gtgacggcgc tcgacctggg cgcgggtcgc
    20641 ttcgatcagc ttgtcgtact ggacgccgga ggggcaggcg gtcacgcacg ccatgcagcc
    20701 gaggcaggcg tcgaagtgct gcaccatctc cggtgtcatc ggctcgccct cgacgccgag
    20761 gcccatcagg tagatccggc cgcgcggcga gtccatctcc tcgccccaca gctggtaggt
    20821 cgggcaggtg ggcaggcaga acccgcagtg cacgcagtcg tccaagaggt ccgccgaggg
    20881 cgggtggtgg tcgtcgaacg cgggcccggt catctcagat ccctcctgcg aaccgtccgg
    20941 gtgccatccg gtgagccggg tcgaactggt ccttgacgcg gcgcatcagc gtgagcccgc
    21001 ggaccggtcc ccacacgtcg agcgtggcct tgacccgcgg tggcgcgtcc agcacgacga
    21061 cgtccccgct ccacgacggc gaaagctcgc gcagccgggt gacgaacgcg ggaaccgcat
    21121 cgggggcccc ggtgaccccg gcgtgcagga ccccgacacc ggccgagccg cgcacggccg
    21181 cactcaggcc gcaccgccgt gccgtgtcgt cgacggcgtc gagcagccgc ggcagcccgg
    21241 cgatctcgtg ggtgagccgc agggccacgc cgtccaccgc ccacggtgcg cggcaccacc
    21301 acgcgggtgg ctcgccggcg acctcggcat ccccgccgag caggtcgagc agggtgtgca
    21361 cgcggccgtc gacgccctcg gggatgcctt cgacgagcac cgccagcgcg gcgggctcga
    21421 cggtggggcg gtcgagttcg accgcgctcg ccaccacctg cgagtgcacc acgcgctgga
    21481 ccttgtcgtg cgcgtcagcc gcggacgcga cggggacgac gacccaccgc gccgcctgcg
    21541 gcagcgggtg caggcggaac acggcctcgg tcaccagccc gagcgttccc cacgagccgg
    21601 tgagcagctt gccgag
//
