LOCUS       NZ_BMWB01000050        14931 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence50, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000050
VERSION     NZ_BMWB01000050.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 14931)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 14931
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000050.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..14931
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     gene            complement(<1..5275)
                     /locus_tag="IE198_RS34260"
     CDS             complement(<1..5275)
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (3-31). E-value:
                     6e-14. Score: 43.3. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (35-461). E-value:
                     8e-183. Score: 600.1. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (564-841). E-value: 7.7e-106.
                     Score: 345.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1171-1346). E-value: 2.3e-58.
                     Score: 189.1. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1451-1523). E-value: 1.3e-32.
                     Score: 103.9. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_ACP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (1543-1757). E-value:
                     5.6e-85. Score: 277.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS34260_PKS_KS.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174579.1"
                     /locus_tag="IE198_RS34260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I polyketide synthase"
                     /protein_id="WP_189893911.1"
                     /sec_met_domain="mod_KS (E-value: 7.8e-228, bitscore:
                     744.0, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 5.5e-97, bitscore:
                     311.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.9e-107, bitscore:
                     345.7, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3e-61, bitscore:
                     194.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.2e-10,
                     bitscore: 25.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5e-17, bitscore:
                     50.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNDDKLRDYLKRVTVDLRHTRRQLGELEAKDTEPVAVVGMACRY
                     PGGVSSPEDLWHLVSSGGDAVTEFPADRGWDLDAIYDPDPGRTGRTYVREGGFLHDAAD
                     FDPAFFGISPREALVMDPQQRLLLQTSWEAFERAGIDPATARGTRAGVFVGTNGQDHAY
                     LQRQGDSDIEAHLVTANTAAVVSGRISYALGLEGPALTVDTACSSSLVALHLATQALRR
                     GECSLALAGGVTVMATPNTFIAFSAQRGLSPDGRCRAFSSTADGTGMSEGVGVLLLERL
                     SDARRLGHDVLAVIRGSAVNQDGASNGLTAPNGPSQVRVIQQALENARLTASQVDAVEA
                     HGTATTLGDPIETDALLATYGQEHSGDQPLWLGSIKSNIGHTQAASGVAGVIKMVMAIR
                     NGVLPQTLHVDEPTTQVDWTAGGVRLLTEAVPWPESDHPRRAAVSSFGVSGTNAHTIIE
                     QAPALDEETIEATAAGALPWVLSAKSDAALRAQAERLLAFLQSGPGRSPADIGFSLATT
                     RAAWDRRAAVVGESLEELTEGLRSLASGTPSAAVFRSTGRLGDKTGFLFSGQGSQRAGM
                     GRELYNAFPAFAAAYDEVRAHLDVTLDVDSEELNRTGCTQPALFAVEVALFRLLESWGV
                     RPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSARAALMQALPAGGAMVAVQATEDEVLA
                     HLTEQVGIAAVNGPQSVVISGAEDAVTAIAEVFTGQGRKTSRLKVSHAFHSPLMDPMLE
                     DFAEVVRGLSFSEPLIPVVSNLTGRLAESYTPEYWVRHVREAVRFADGVQTLHDLGVST
                     FVEIGPGGVLSALAQGCLDDDVVTVPVLRADRPEQQAVTAALAELHVHGVSPDWKALFP
                     GARKTDLPTYAFQQQRYWLDAPEAEAALVDAVDAEFWASVEREDAESLAATLGLSAEEL
                     DVVVPKLSAWRRQRREQAVVDGWRYQLTWQPLKGLVSGDLSGSTWLFAAPEGDGWAGTV
                     RAALAGRGARLIPLTVGADADRESLAAELTRGAAEAGSLAGILSLLAIDENAPPEHPAL
                     SRGLAQTVALAQALGDAGIDAPLWCATRGAAVTGRSDDAPPSAVQNQVGGFGRALALEH
                     ARRWGGLVDLPETVDDRVAGRLAAVLGQSAEDQVAIRARGVFGRRLTRSAARRDGRAGH
                     QWSPRGTVLITGGTGALGGHVARWLAGAGAEHLVLTSRRGADAPGAAALKTELEELGAR
                     VSLAACDVADRDAVAALLAEHTFTSVFHAAGVEQFAPFDELTPADFARTIAAKAGGAAH
                     LDELLGDRELDAFVLFSSIAGVWGSGLQTAYAAANSFLDGLAARRRAEGLTATAIAWGP
                     WADGGMVTEADEEHLRRRGVISLPAELAVTAVQRALDCDDTAAVVADIDWERFIGPFTL
                     GRPSALLSELPETRRAESAAPAADAAAGTAPLAAQLAGLPEAKRTETLIDLVRAHVAAV
                     LGHASAADVEPDRAFKDLGFDSLTAVELRNKVNTATGLALPPTLVFDYPNATALARFLQ
                     RELLGSQAAAPQDRHAAAADDEPIAIVAMSCHLPGGVDSPEALWDLVASGGDAISEFPS
                     DRGWDVGSLYDPDPERLGKTYARDGGFLYDATDFDASFFGISPREALAMDPQQRLLLET
                     SWEAFERAGITPGQLRGSRTGVFVGMAYQGYGADVRRTPEGVEGHRLVGGASSVVSGRV
                     AYTFGLEGPAVTIDTACSSSLVALHLAVQSLRNGECTMALAGGVTVMAGPTVFVEFSRQ
                     RG"
     source          1..14931
                     /culture_collection="JCM:4863"
                     /db_xref="taxon:68285"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces xantholiticus"
                     /strain="JCM 4863"
                     /submitter_seqid="sequence50"
                     /type_material="type strain of Streptomyces xantholiticus"
     cand_cluster    1..14931
                     /SMILES="C([*])C(-O)C=CCC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14931
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[<0:10781](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..10781)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     aSDomain        complement(5..646)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_PKS_KS.2"
                     /domain_subtypes="Modular-KS"
                     /evalue="5.60E-85"
                     /label="IE198_RS34260_PKS_KS.2"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1757"
                     /protein_start="1543"
                     /score="277.7"
                     /tool="antismash"
                     /translation="IAIVAMSCHLPGGVDSPEALWDLVASGGDAISEFPSDRGWDVGSL
                     YDPDPERLGKTYARDGGFLYDATDFDASFFGISPREALAMDPQQRLLLETSWEAFERAG
                     ITPGQLRGSRTGVFVGMAYQGYGADVRRTPEGVEGHRLVGGASSVVSGRVAYTFGLEGP
                     AVTIDTACSSSLVALHLAVQSLRNGECTMALAGGVTVMAGPTVFVEFSRQR"
     CDS_motif       complement(116..163)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0014"
                     /evalue="9.50E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1720"
                     /protein_start="1704"
                     /score="20.7"
                     /tool="antismash"
                     /translation="GPAVTIDTACSSSLVA"
     CDS_motif       complement(365..391)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0013"
                     /evalue="2.80E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1637"
                     /protein_start="1628"
                     /score="7.6"
                     /tool="antismash"
                     /translation="DPQQRLLLE"
     aSDomain        complement(707..922)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_ACP.1"
                     /evalue="1.30E-32"
                     /label="IE198_RS34260_ACP.1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1523"
                     /protein_start="1451"
                     /score="103.9"
                     /tool="antismash"
                     /translation="DLVRAHVAAVLGHASAADVEPDRAFKDLGFDSLTAVELRNKVNTA
                     TGLALPPTLVFDYPNATALARFLQREL"
     aSModule        complement(707..5170)
                     /complete
                     /domains="nrpspksdomains_IE198_RS34260_PKS_KS.1"
                     /domains="nrpspksdomains_IE198_RS34260_PKS_AT.1"
                     /domains="nrpspksdomains_IE198_RS34260_PKS_KR.1"
                     /domains="nrpspksdomains_IE198_RS34260_ACP.1"
                     /locus_tags="IE198_RS34260"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(1109..1171)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0012"
                     /evalue="1.30E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1389"
                     /protein_start="1368"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="ELAVTAVQRALDCDDTAAVVA"
     aSDomain        complement(1238..1762)
                     /ASF="KR domain putatively catalyzing L-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_PKS_KR.1"
                     /evalue="2.30E-58"
                     /label="IE198_RS34260_PKS_KR.1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1346"
                     /protein_start="1171"
                     /score="189.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: A1"
                     /tool="antismash"
                     /translation="GTVLITGGTGALGGHVARWLAGAGAEHLVLTSRRGADAPGAAALK
                     TELEELGARVSLAACDVADRDAVAALLAEHTFTSVFHAAGVEQFAPFDELTPADFARTI
                     AAKAGGAAHLDELLGDRELDAFVLFSSIAGVWGSGLQTAYAAANSFLDGLAARRRAEGL
                     TATAIAWGPWAD"
     CDS_motif       complement(1286..1396)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0011"
                     /evalue="5.60E-18"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1330"
                     /protein_start="1293"
                     /score="57.5"
                     /tool="antismash"
                     /translation="LDAFVLFSSIAGVWGSGLQTAYAAANSFLDGLAARRR"
     CDS_motif       complement(1661..1759)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0010"
                     /evalue="1.40E-13"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="1205"
                     /protein_start="1172"
                     /score="43.4"
                     /tool="antismash"
                     /translation="TVLITGGTGALGGHVARWLAGAGAEHLVLTSRR"
     aSDomain        complement(2753..3583)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_PKS_AT.1"
                     /evalue="7.70E-106"
                     /label="IE198_RS34260_PKS_AT.1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="841"
                     /protein_start="564"
                     /score="345.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQRAGMGRELYNAFPAFAAAYDEVRAHLDVTLDVDSEEL
                     NRTGCTQPALFAVEVALFRLLESWGVRPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSA
                     RAALMQALPAGGAMVAVQATEDEVLAHLTEQVGIAAVNGPQSVVISGAEDAVTAIAEVF
                     TGQGRKTSRLKVSHAFHSPLMDPMLEDFAEVVRGLSFSEPLIPVVSNLTGRLAESYTPE
                     YWVRHVREAVRFADGVQTLHDLGVSTFVEIGPGGVLSALAQGCLDDDVVTVPVLR"
     CDS_motif       complement(2882..2917)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0009"
                     /evalue="7.10E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE198_RS34260"
                     /protein_end="798"
                     /protein_start="786"
                     /score="16.1"
                     /tool="antismash"
                     /translation="YWVRHVREAVRF"
     CDS_motif       complement(3131..3169)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0008"
                     /evalue="8.50E-05"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS34260"
                     /protein_end="715"
                     /protein_start="702"
                     /score="15.7"
                     /tool="antismash"
                     /translation="AAVNGPQSVVISG"
     CDS_motif       complement(3254..3376)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0007"
                     /evalue="6.40E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE198_RS34260"
                     /protein_end="674"
                     /protein_start="633"
                     /score="73.1"
                     /tool="antismash"
                     /translation="GVRPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSARAALMQ"
     CDS_motif       complement(3386..3445)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0006"
                     /evalue="6.20E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE198_RS34260"
                     /protein_end="630"
                     /protein_start="610"
                     /score="13.0"
                     /tool="antismash"
                     /translation="RTGCTQPALFAVEVALFRLL"
     CDS_motif       complement(3533..3586)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0005"
                     /evalue="5.90E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="581"
                     /protein_start="563"
                     /score="18.6"
                     /tool="antismash"
                     /translation="FLFSGQGSQRAGMGRELY"
     misc_feature    complement(3671..3673)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(3893..5170)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="8.00E-183"
                     /label="IE198_RS34260_PKS_KS.1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="461"
                     /protein_start="35"
                     /score="600.1"
                     /tool="antismash"
                     /translation="VAVVGMACRYPGGVSSPEDLWHLVSSGGDAVTEFPADRGWDLDAI
                     YDPDPGRTGRTYVREGGFLHDAADFDPAFFGISPREALVMDPQQRLLLQTSWEAFERAG
                     IDPATARGTRAGVFVGTNGQDHAYLQRQGDSDIEAHLVTANTAAVVSGRISYALGLEGP
                     ALTVDTACSSSLVALHLATQALRRGECSLALAGGVTVMATPNTFIAFSAQRGLSPDGRC
                     RAFSSTADGTGMSEGVGVLLLERLSDARRLGHDVLAVIRGSAVNQDGASNGLTAPNGPS
                     QVRVIQQALENARLTASQVDAVEAHGTATTLGDPIETDALLATYGQEHSGDQPLWLGSI
                     KSNIGHTQAASGVAGVIKMVMAIRNGVLPQTLHVDEPTTQVDWTAGGVRLLTEAVPWPE
                     SDHPRRAAVSSFGVSGTNAHTIIEQAP"
     CDS_motif       complement(4115..4159)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0004"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE198_RS34260"
                     /protein_end="387"
                     /protein_start="372"
                     /score="11.4"
                     /tool="antismash"
                     /translation="GSIKSNIGHTQAASG"
     CDS_motif       complement(4220..4264)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0003"
                     /evalue="2.80E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE198_RS34260"
                     /protein_end="352"
                     /protein_start="337"
                     /score="10.4"
                     /tool="antismash"
                     /translation="VEAHGTATTLGDPIE"
     CDS_motif       complement(4640..4687)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0002"
                     /evalue="9.20E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE198_RS34260"
                     /protein_end="212"
                     /protein_start="196"
                     /score="20.7"
                     /tool="antismash"
                     /translation="GPALTVDTACSSSLVA"
     CDS_motif       complement(4889..4915)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34260_0001"
                     /evalue="7.30E-02"
                     /label="PKSI-KS_m2"
                     /locus_tag="IE198_RS34260"
                     /protein_end="129"
                     /protein_start="120"
                     /score="6.4"
                     /tool="antismash"
                     /translation="DPQQRLLLQ"
     aSDomain        complement(5183..5266)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34260_PKS_Docking_Nterm.
                     1"
                     /evalue="6.00E-14"
                     /label="IE198_RS34260_PKS_Docking_Nterm.1"
                     /locus_tag="IE198_RS34260"
                     /protein_end="31"
                     /protein_start="3"
                     /score="43.3"
                     /tool="antismash"
                     /translation="DDKLRDYLKRVTVDLRHTRRQLGELEAK"
     gene            complement(5310..10781)
                     /locus_tag="IE198_RS34265"
                     /old_locus_tag="GCM10010381_69720"
     CDS             complement(5310..10781)
                     /EC_number="2.3.1.-"
                     /EC_number="6.4.-.-"
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (2-30). E-value:
                     6.6e-15. Score: 46.4. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (34-457). E-value:
                     9.9e-183. Score: 599.8. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (576-853). E-value: 3.3e-104.
                     Score: 340.4. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (919-1075). E-value: 3.7e-47.
                     Score: 152.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1375-1555). E-value: 4.7e-59.
                     Score: 191.3. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1660-1731). E-value: 1.4e-29.
                     Score: 94.2. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_ACP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (1742-1822). E-value:
                     4.8e-20. Score: 64.2. Matches aSDomain:
                     nrpspksdomains_IE198_RS34265_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981854.1"
                     /locus_tag="IE198_RS34265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_69720"
                     /product="type I polyketide synthase"
                     /protein_id="WP_189893916.1"
                     /sec_met_domain="mod_KS (E-value: 8e-231, bitscore: 753.8,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 4.6e-97, bitscore:
                     312.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.7e-105, bitscore:
                     340.4, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.6e-64, bitscore:
                     203.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.2e-14, bitscore:
                     41.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEEKLRDYLKRATTDLRQARRRVRELEARDQEPIAIVGMSCRFP
                     GGIGSPEALWRLLAEGGDAISQFPEDRGWDVDSLYDPDPEQPGKVYTRQGGFLHDAADF
                     DADFFGISPREALAMDPQQRLLLETAWEAFEHAGIDLAPLKGSRTGVFAGLMYHDYGFT
                     PGVLPDGVEGLLSTGNSGSVASGRIAYTFGFEGPAVTIDTACSSSLVALHLAVQALRSG
                     ECSMALAGGVTVMAGPSAFVEFSRQRGLASDGRCKSFAAAADGASWSEGAGLLLVERLR
                     DARRLGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVILEALADGGLSAEEIDAVEAH
                     GTGTNLGDPIEAQALLATYGQDRERPLLLGSLKSNIGHTQAAAGVAGVIKMVLAMQHGV
                     LPRTLHVDRPTPQVDWSAGSVELLTEAAAWPESDHPRRAGVSSFGISGTNAHVILEQAT
                     ERAAEEPADDTAGGGGAAADEPLRPRTSVLPWVLSGKTGEALREQAQRLLSSVDLAAAS
                     PADVGFSLAATRSALEHRAAVVGADEDELRAGLTALAAGNPAAHVVTGRADAARGKVGF
                     LFSGQGSQRLGMGRELYEAYPAFTAAYDEVCARLDAPVDVDAETLHRTGCTQPALFAVE
                     VALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSARAALMQALPAGGAM
                     VAIQGTEDEVLPHLTGQTGIAAVNGPQSVVVSGAEDAVVEIAEVFAGQGRKTSRLKVSH
                     AFHSPLMDPMLEDFAEVVRGLSFSEPRIPVVSNLTGRLAEPYTPEYWVRHVREAVRFAD
                     GLQTLHDLGVSTFVEVGPGGVLSALTQACLDDDVVTVPVLRTDRPEPQAVTAALAELHV
                     HGVSPDWQALFPGARRVGLPTYAFQRERYWLEGTVAPDVSSAGLDSSGHPLLGAVVETA
                     GGQDVLFTGRLSPADTPWIAEHTVGGVPVLPAAAFVELALGAGRQAGFPHLEQLDMDVP
                     LVLAEQGAVRIQVQVGAGDDTDRRSVRVFSRAAAGGADEAWVCHVTGELTRSAPAAEFD
                     MVIWPPAGAEPVDVENHPSLRAAWRAGDELYAETALPLAERDRADGYRLHPVLLDAVLD
                     TLALDGAGDPGRVLMPYAWSGTSVHAPGAANVRLRIRPAAGDAVAIELADTDGAPVASV
                     ASLRTRTVSPQQLLASRVAQQDWMFEVDWVEHTAPAASAPEAEWAVLGGDGPYADIDAL
                     REAVDDGAAPPAHVLLPCAPSESGAASATRELLAGVLSAVQKWVADERFSDARLVVMTR
                     GAVDLDGAAPDLAHVAVVGLVKSAQSEHPDRLLLVDADDFVADGGVDPALVAALAALDE
                     PQAAVRDGKLFVPRLARIAPSEEPTDHAWDPEGTVLLTGATGGLGRLLARHLVAERGAR
                     RLLMVSRRGPAAEGIGEVVAALSELGAHVDVAACDIADRDALAELLASVPAEHPLVAVV
                     HAAAALDDGVITALTPERLDTVLRPKADGALHLHELTKDLDLSAFVLFSSLAGVLGSAG
                     AASYAAANAFLDGLARQRRAAGLPGSSLAWGLWTDNGGMGDRITDADRNRMGRAGVVPF
                     TSAEGLALFDVALTADRPVIVPVRLDVAGLRSMARAGMMPAVFRGLVGDTGGTAEGAAA
                     AGTPALARRLAGMPEADQEKVLLDLVRNQAAAALGHATAARIEPTTAFRDIGFDSLTSV
                     ELRNRLKAATGLRLKSTLVFDHPNPVAIARLLHKDLVLDLGAATPPVLDELDRLEAQLA
                     ALDLQDAVRDKVTARLKALLWKWTDIQQDTAANSADAGPGTDRDFDRIDAATDDEMFDL
                     IDQELGSL"
     aSDomain        complement(5316..5555)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_Docking_Cterm.
                     1"
                     /evalue="4.80E-20"
                     /label="IE198_RS34265_PKS_Docking_Cterm.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1822"
                     /protein_start="1742"
                     /score="64.2"
                     /tool="antismash"
                     /translation="PVLDELDRLEAQLAALDLQDAVRDKVTARLKALLWKWTDIQQDTA
                     ANSADAGPGTDRDFDRIDAATDDEMFDLIDQELGS"
     aSDomain        complement(5589..5801)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_ACP.1"
                     /evalue="1.40E-29"
                     /label="IE198_RS34265_ACP.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1731"
                     /protein_start="1660"
                     /score="94.2"
                     /tool="antismash"
                     /translation="LDLVRNQAAAALGHATAARIEPTTAFRDIGFDSLTSVELRNRLKA
                     ATGLRLKSTLVFDHPNPVAIARLLHK"
     aSModule        complement(5589..10679)
                     /complete
                     /domains="nrpspksdomains_IE198_RS34265_PKS_KS.1"
                     /domains="nrpspksdomains_IE198_RS34265_PKS_AT.1"
                     /domains="nrpspksdomains_IE198_RS34265_PKS_DH.1"
                     /domains="nrpspksdomains_IE198_RS34265_PKS_KR.1"
                     /domains="nrpspksdomains_IE198_RS34265_ACP.1"
                     /locus_tags="IE198_RS34265"
                     /monomer_pairings="mal -> ccmal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(6117..6656)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_KR.1"
                     /evalue="4.70E-59"
                     /label="IE198_RS34265_PKS_KR.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1555"
                     /protein_start="1375"
                     /score="191.3"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLLTGATGGLGRLLARHLVAERGARRLLMVSRRGPAAEGIGEV
                     VAALSELGAHVDVAACDIADRDALAELLASVPAEHPLVAVVHAAAALDDGVITALTPER
                     LDTVLRPKADGALHLHELTKDLDLSAFVLFSSLAGVLGSAGAASYAAANAFLDGLARQR
                     RAAGLPGSSLAWGLWTD"
     CDS_motif       complement(6165..6269)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0011"
                     /evalue="5.50E-17"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1539"
                     /protein_start="1504"
                     /score="54.3"
                     /tool="antismash"
                     /translation="AFVLFSSLAGVLGSAGAASYAAANAFLDGLARQRR"
     CDS_motif       complement(6552..6653)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0010"
                     /evalue="6.20E-10"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1410"
                     /protein_start="1376"
                     /score="31.7"
                     /tool="antismash"
                     /translation="TVLLTGATGGLGRLLARHLVAERGARRLLMVSRR"
     aSDomain        complement(7557..8024)
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_DH.1"
                     /evalue="3.70E-47"
                     /label="IE198_RS34265_PKS_DH.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="1075"
                     /protein_start="919"
                     /score="152.7"
                     /tool="antismash"
                     /translation="HPLLGAVVETAGGQDVLFTGRLSPADTPWIAEHTVGGVPVLPAAA
                     FVELALGAGRQAGFPHLEQLDMDVPLVLAEQGAVRIQVQVGAGDDTDRRSVRVFSRAAA
                     GGADEAWVCHVTGELTRSAPAAEFDMVIWPPAGAEPVDVENHPSLRAAWRAG"
     CDS_motif       complement(7866..7940)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0009"
                     /evalue="2.30E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="IE198_RS34265"
                     /protein_end="972"
                     /protein_start="947"
                     /score="29.7"
                     /tool="antismash"
                     /translation="WIAEHTVGGVPVLPAAAFVELALGA"
     aSDomain        complement(8223..9053)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_AT.1"
                     /evalue="3.30E-104"
                     /label="IE198_RS34265_PKS_AT.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="853"
                     /protein_start="576"
                     /score="340.4"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQRLGMGRELYEAYPAFTAAYDEVCARLDAPVDVDAETL
                     HRTGCTQPALFAVEVALFRLLESWGIRPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSA
                     RAALMQALPAGGAMVAIQGTEDEVLPHLTGQTGIAAVNGPQSVVVSGAEDAVVEIAEVF
                     AGQGRKTSRLKVSHAFHSPLMDPMLEDFAEVVRGLSFSEPRIPVVSNLTGRLAEPYTPE
                     YWVRHVREAVRFADGLQTLHDLGVSTFVEVGPGGVLSALTQACLDDDVVTVPVLR"
     CDS_motif       complement(8352..8387)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0008"
                     /evalue="7.40E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE198_RS34265"
                     /protein_end="810"
                     /protein_start="798"
                     /score="16.1"
                     /tool="antismash"
                     /translation="YWVRHVREAVRF"
     CDS_motif       complement(8601..8639)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0007"
                     /evalue="1.20E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS34265"
                     /protein_end="727"
                     /protein_start="714"
                     /score="15.2"
                     /tool="antismash"
                     /translation="AAVNGPQSVVVSG"
     CDS_motif       complement(8724..8846)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0006"
                     /evalue="3.80E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE198_RS34265"
                     /protein_end="686"
                     /protein_start="645"
                     /score="73.8"
                     /tool="antismash"
                     /translation="GIRPDYVAGHSVGEIAAAHVAGVLSLEDAARLVSARAALMQ"
     CDS_motif       complement(8856..8909)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0005"
                     /evalue="7.50E-04"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE198_RS34265"
                     /protein_end="642"
                     /protein_start="624"
                     /score="12.8"
                     /tool="antismash"
                     /translation="GCTQPALFAVEVALFRLL"
     CDS_motif       complement(9003..9056)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0004"
                     /evalue="1.60E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="593"
                     /protein_start="575"
                     /score="17.3"
                     /tool="antismash"
                     /translation="FLFSGQGSQRLGMGRELY"
     aSDomain        complement(9411..10679)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="9.90E-183"
                     /label="IE198_RS34265_PKS_KS.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="457"
                     /protein_start="34"
                     /score="599.8"
                     /tool="antismash"
                     /translation="IAIVGMSCRFPGGIGSPEALWRLLAEGGDAISQFPEDRGWDVDSL
                     YDPDPEQPGKVYTRQGGFLHDAADFDADFFGISPREALAMDPQQRLLLETAWEAFEHAG
                     IDLAPLKGSRTGVFAGLMYHDYGFTPGVLPDGVEGLLSTGNSGSVASGRIAYTFGFEGP
                     AVTIDTACSSSLVALHLAVQALRSGECSMALAGGVTVMAGPSAFVEFSRQRGLASDGRC
                     KSFAAAADGASWSEGAGLLLVERLRDARRLGHRVLAVVRGSAVNQDGASNGLTAPNGPS
                     QQRVILEALADGGLSAEEIDAVEAHGTGTNLGDPIEAQALLATYGQDRERPLLLGSLKS
                     NIGHTQAAAGVAGVIKMVLAMQHGVLPRTLHVDRPTPQVDWSAGSVELLTEAAAWPESD
                     HPRRAGVSSFGISGTNAHVILEQA"
     CDS_motif       complement(9630..9674)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0003"
                     /evalue="2.20E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE198_RS34265"
                     /protein_end="384"
                     /protein_start="369"
                     /score="10.7"
                     /tool="antismash"
                     /translation="GSLKSNIGHTQAAAG"
     CDS_motif       complement(9729..9773)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0002"
                     /evalue="4.10E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE198_RS34265"
                     /protein_end="351"
                     /protein_start="336"
                     /score="12.6"
                     /tool="antismash"
                     /translation="VEAHGTGTNLGDPIE"
     CDS_motif       complement(10149..10196)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34265_0001"
                     /evalue="9.90E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE198_RS34265"
                     /protein_end="211"
                     /protein_start="195"
                     /score="20.6"
                     /tool="antismash"
                     /translation="GPAVTIDTACSSSLVA"
     aSDomain        complement(10692..10775)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34265_PKS_Docking_Nterm.
                     1"
                     /evalue="6.60E-15"
                     /label="IE198_RS34265_PKS_Docking_Nterm.1"
                     /locus_tag="IE198_RS34265"
                     /protein_end="30"
                     /protein_start="2"
                     /score="46.4"
                     /tool="antismash"
                     /translation="EEKLRDYLKRATTDLRQARRRVRELEAR"
     CDS             complement(10817..>14927)
                     /EC_number="2.3.1.-"
                     /EC_number="6.4.-.-"
                     /NRPS_PKS="Domain: PKS_AT (111-407). E-value: 3.7e-106.
                     Score: 346.8. Matches aSDomain:
                     nrpspksdomains_IE198_RS34270_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (472-632). E-value: 8.9e-64.
                     Score: 206.8. Matches aSDomain:
                     nrpspksdomains_IE198_RS34270_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (936-1109). E-value: 7.2e-55.
                     Score: 177.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS34270_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1210-1281). E-value: 2.6e-32.
                     Score: 102.9. Matches aSDomain:
                     nrpspksdomains_IE198_RS34270_ACP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (1292-1369). E-value:
                     2.4e-13. Score: 42.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS34270_PKS_Docking_Cterm.1"
                     /codon_start=3
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981855.1"
                     /locus_tag="IE198_RS34270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I polyketide synthase"
                     /protein_id="WP_189893914.1"
                     /sec_met_domain="PKS_AT (E-value: 1.8e-107, bitscore:
                     346.8, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 8.8e-59, bitscore:
                     186.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.4e-17, bitscore:
                     51.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="QAPATAEPPPTPDSGTLVPWVLSGRTEAALRAQAARLASFLADTD
                     TDGDVAATAADAAYSLATTRAAFEHRAVVVADTPEELRQGLAAVADGSTPPGVVTGTAR
                     AGGKTVFVFPGQGSQWAGMAAELLETSQVFRDRIDACERALAPHVDWSLTAVLRGASDV
                     EQDRVDVLQPVLWAMTVALAEVWRSFGVTPDAVVGHSQGEVSAAVIAGAVSLEDAARIV
                     AQRSLAVRELQGRGGMVSVTLPEEEVQVLVGRWAGRLDIGAVNGPGTVVVSGDTDALDE
                     LLAYCGKEGIQARKVAVDYAAHSPQIERVETQAGEGFAGIGPLPGTVPFYSTVTGGKLD
                     AGELGSGYWYRNMRQTVRFHDAIRSALADGHDVFVEVSPHPVQLAGIQDAIEAAEAEAV
                     VVPTLRRGDGGRHRLLLSLAQAHAHGVAIDWNAVLPGARRVDLPTYAFQHERYWLEAGA
                     PAGDVRAAGLDFADHPFLGAAVELPDAGGHLLTGLLSLQAQPWLADHAVLGTVLLPGTA
                     FVELAAHAAAETGCDLVEELTLQAPLLLPEHGGVQIQVLVGAQDDSGRRPLSVHSRAGE
                     GPWIRNATGALATGGTPSGTDLSSWPPADARPVDLDGFYDRLADLGLSYGPLFRGLRAA
                     WRGNDAVYAELAVPDEAHADADAFGVHPALLDSALHALGAGGLVPAADGPLLPFAWSRV
                     TVHGTGAAALRVRLSQAGGHAVRLEAADGTGRPVVSVESLTLRPVSADQLRTSSRDSLF
                     TVEWAPLAAPSEANGPAVRAYDDIALLLRAPETEPGAEAEVDAVVVPCPAGSGSEAERV
                     REVLAEVLGLVQVWLAEDRAARLVLVTRGAVAAGDDPAPADPAQAAVWGLVRSAQSENP
                     DRIVLLDTDENTDRDTDWQQAVATAVPRLLASEEPQAALRGGTLLLPRLARATADAPQG
                     APDFGTGTVLLTGASGALGGLVARHLVAEHGVRSLLLMSRRGADAEGAAELRAELAASG
                     AEVHWAACDVADRDALAGALAGMPVTAVVHTAGVLDDGVIGSLTPERLDAVLRPKVDAV
                     LNLHELTGEVSAFVVFSSLAGTLGTPGQANYAAANAFLDAFAGRRRAQGLPAVSLPWGL
                     WQRTGTMTEDLGGVDRTRLARGGVVPLSDEDGLELLDAALALEEPLVVAARVDIAALRN
                     AAAPVPPLLRTLVGGRPRRTDRAAAVPLAQRVADLPESEREEVVLDLVRSEVAAVLGHS
                     SAKSVQPDQAFGDLGFDSLTAVEFRSRMNKATGLRLPATLVFDHPTPTALAQRVLKDLP
                     GGTGGTVSVFDEIDRLAAALDGAGADSVGNITRIKINMRLQALLARWNGNEPADPGGAG
                     GAEDEDDLSSASDEELYELLDGELGIS"
     gene            complement(10817..>14931)
                     /locus_tag="IE198_RS34270"
     aSDomain        complement(10820..11050)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34270_PKS_Docking_Cterm.
                     1"
                     /evalue="2.40E-13"
                     /label="IE198_RS34270_PKS_Docking_Cterm.1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="1369"
                     /protein_start="1292"
                     /score="42.7"
                     /tool="antismash"
                     /translation="VFDEIDRLAAALDGAGADSVGNITRIKINMRLQALLARWNGNEPA
                     DPGGAGGAEDEDDLSSASDEELYELLDGELGI"
     aSDomain        complement(11084..11296)
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34270_ACP.1"
                     /evalue="2.60E-32"
                     /label="IE198_RS34270_ACP.1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="1281"
                     /protein_start="1210"
                     /score="102.9"
                     /tool="antismash"
                     /translation="LDLVRSEVAAVLGHSSAKSVQPDQAFGDLGFDSLTAVEFRSRMNK
                     ATGLRLPATLVFDHPTPTALAQRVLK"
     aSModule        complement(11084..14593)
                     /complete
                     /domains="nrpspksdomains_IE198_RS34270_PKS_AT.1"
                     /domains="nrpspksdomains_IE198_RS34270_PKS_DH.1"
                     /domains="nrpspksdomains_IE198_RS34270_PKS_KR.1"
                     /domains="nrpspksdomains_IE198_RS34270_ACP.1"
                     /locus_tags="IE198_RS34270"
                     /monomer_pairings="pk -> pk"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(11600..12118)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34270_PKS_KR.1"
                     /evalue="7.20E-55"
                     /label="IE198_RS34270_PKS_KR.1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="1109"
                     /protein_start="936"
                     /score="177.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLLTGASGALGGLVARHLVAEHGVRSLLLMSRRGADAEGAAEL
                     RAELAASGAEVHWAACDVADRDALAGALAGMPVTAVVHTAGVLDDGVIGSLTPERLDAV
                     LRPKVDAVLNLHELTGEVSAFVVFSSLAGTLGTPGQANYAAANAFLDAFAGRRRAQGLP
                     AVSLPWGLWQ"
     CDS_motif       complement(11645..11746)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0010"
                     /evalue="1.70E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="IE198_RS34270"
                     /protein_end="1094"
                     /protein_start="1060"
                     /score="62.4"
                     /tool="antismash"
                     /translation="FVVFSSLAGTLGTPGQANYAAANAFLDAFAGRRR"
     CDS_motif       complement(12014..12115)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0009"
                     /evalue="9.60E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="971"
                     /protein_start="937"
                     /score="21.5"
                     /tool="antismash"
                     /translation="TVLLTGASGALGGLVARHLVAEHGVRSLLLMSRR"
     aSDomain        complement(13031..13510)
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34270_PKS_DH.1"
                     /evalue="8.90E-64"
                     /label="IE198_RS34270_PKS_DH.1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="632"
                     /protein_start="472"
                     /score="206.8"
                     /tool="antismash"
                     /translation="HPFLGAAVELPDAGGHLLTGLLSLQAQPWLADHAVLGTVLLPGTA
                     FVELAAHAAAETGCDLVEELTLQAPLLLPEHGGVQIQVLVGAQDDSGRRPLSVHSRAGE
                     GPWIRNATGALATGGTPSGTDLSSWPPADARPVDLDGFYDRLADLGLSYGPLFRGL"
     CDS_motif       complement(13349..13426)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0008"
                     /evalue="3.40E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="IE198_RS34270"
                     /protein_end="526"
                     /protein_start="500"
                     /score="29.2"
                     /tool="antismash"
                     /translation="WLADHAVLGTVLLPGTAFVELAAHAA"
     aSDomain        complement(13706..14593)
                     /ASF="Neither malonyl-CoA or methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS34270_PKS_AT.1"
                     /evalue="3.70E-106"
                     /label="IE198_RS34270_PKS_AT.1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="407"
                     /protein_start="111"
                     /score="346.8"
                     /specificity="substrate consensus: pk"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: emal"
                     /tool="antismash"
                     /translation="VFPGQGSQWAGMAAELLETSQVFRDRIDACERALAPHVDWSLTAV
                     LRGASDVEQDRVDVLQPVLWAMTVALAEVWRSFGVTPDAVVGHSQGEVSAAVIAGAVSL
                     EDAARIVAQRSLAVRELQGRGGMVSVTLPEEEVQVLVGRWAGRLDIGAVNGPGTVVVSG
                     DTDALDELLAYCGKEGIQARKVAVDYAAHSPQIERVETQAGEGFAGIGPLPGTVPFYST
                     VTGGKLDAGELGSGYWYRNMRQTVRFHDAIRSALADGHDVFVEVSPHPVQLAGIQDAIE
                     AAEAEAVVVPTLRRG"
     CDS_motif       complement(13781..13807)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0007"
                     /evalue="1.10E-02"
                     /label="PKSI-AT-mM_m9"
                     /locus_tag="IE198_RS34270"
                     /protein_end="382"
                     /protein_start="373"
                     /score="8.7"
                     /tool="antismash"
                     /translation="FVEVSPHPV"
     CDS_motif       complement(13850..13897)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0006"
                     /evalue="2.30E-04"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="IE198_RS34270"
                     /protein_end="359"
                     /protein_start="343"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LGSGYWYRNMRQTVRF"
     CDS_motif       complement(14003..14035)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0005"
                     /evalue="3.10E-03"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="IE198_RS34270"
                     /protein_end="308"
                     /protein_start="297"
                     /score="10.5"
                     /tool="antismash"
                     /translation="VDYAAHSPQIE"
     CDS_motif       complement(14105..14140)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0004"
                     /evalue="1.20E-02"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS34270"
                     /protein_end="274"
                     /protein_start="262"
                     /score="9.1"
                     /tool="antismash"
                     /translation="AVNGPGTVVVSG"
     CDS_motif       complement(14249..14359)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0003"
                     /evalue="2.60E-18"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="IE198_RS34270"
                     /protein_end="226"
                     /protein_start="189"
                     /score="57.8"
                     /tool="antismash"
                     /translation="GVTPDAVVGHSQGEVSAAVIAGAVSLEDAARIVAQRS"
     CDS_motif       complement(14363..14431)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0002"
                     /evalue="4.80E-08"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE198_RS34270"
                     /protein_end="188"
                     /protein_start="165"
                     /score="25.5"
                     /tool="antismash"
                     /translation="DRVDVLQPVLWAMTVALAEVWRS"
     CDS_motif       complement(14543..14599)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS34270_0001"
                     /evalue="5.90E-10"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="IE198_RS34270"
                     /protein_end="128"
                     /protein_start="109"
                     /score="30.7"
                     /tool="antismash"
                     /translation="VFVFPGQGSQWAGMAAELL"
ORIGIN
        1 gcccgcgctg gcggctgaac tccacgaaga ccgtcgggcc ggccatgacg gtgacgccgc
       61 cggccagggc catggtgcac tcaccgttgc gcaacgactg gacggccagg tgaagggcga
      121 cgagcgacga cgagcacgcc gtgtcgatcg tgacggcggg gccttcgaga ccgaaggtgt
      181 aggccacccg cccggagacg acgctggacg cgccgccgac caaccggtgt ccttcgacgc
      241 cttccggcgt ccgccgcacg tcggctccat agccctggta ggccatgccg acgaagacgc
      301 cggtccggct gccgcgcagc tgtccggggg tgatcccggc ccgctcgaag gcctcccagg
      361 aggtctccag cagcagccgc tgctgcgggt ccatcgccag ggcctcgcgg gggctgatgc
      421 cgaagaagga ggcgtcgaag tcggtggcgt cgtagaggaa accgccgtcg cgcgcgtacg
      481 tcttgccgag gcgctcggga tcggggtcgt agagcgagcc gacgtcccag ccacggtcgg
      541 acgggaattc cgagatggcg tcaccgccgg acgccaccag gtcccacagg gcctcgggcg
      601 agtcgacgcc gcccggcagg tggcagctca tcgccacgat ggcgatgggc tcgtcgtcgg
      661 cggcggccgc gtgccgatcc tgcggcgcgg cggcctgtga tccgagaagc tcgcgctgca
      721 ggaagcgggc gagcgccgtg gcgttggggt agtcgaagac cagtgtgggc ggcagcgcga
      781 ggccggtcgc cgtgttgacc ttgttgcgga gttcgacggc ggtcagggag tcgaagccga
      841 ggtccttgaa cgcccggtcg ggctcgacgt ctgccgccga ggcgtggccc aggacggccg
      901 cgacgtgtgc gcggaccagg tcgatcaggg tctcggtgcg cttggcctcc ggcagtccgg
      961 cgagctgggc agccaggggt gcggtgcccg cggcggcgtc ggcggccggc gcggcggact
     1021 cggcgcggcg cgtctcgggc agctcggaca gcagtgcgct ggggcggccg agggtgaacg
     1081 gtccgatgaa ccgttcccag tcgatgtcgg ccacaacggc cgcggtgtcg tcgcagtcca
     1141 gggcgcgctg gaccgcggtc acggcgagct cggccggcag ggagatgacg ccgcggcggc
     1201 gcaggtgctc ctcgtcggcc tcggtgacca tgccgccgtc ggcccagggg ccccaggcga
     1261 tcgcggtggc ggtcaggccc tcggccctcc gccgggcggc gagcccgtcg aggaaggagt
     1321 tggcggccgc gtaggcggtc tgcagtccgc tgccccacac gccggcgatc gaggagaaga
     1381 ggacgaaggc gtccaactcc cggtcgccca gcagttcgtc caggtgtgcg gcaccgccgg
     1441 ccttcgccgc gatcgtgcgg gcgaagtcgg ccggggtcag ctcgtcgaag ggggcgaact
     1501 gttccacgcc cgcggcgtgg aacaccgagg tgaaggtgtg ctcggcgagc agcgccgcca
     1561 cggcatcgcg gtcggcgacg tcgcacgccg cgaggctgac gcgtgctccc agctcttcca
     1621 gttcggtctt gagggcagcc gcgccggggg cgtcggcgcc gcggcggctg gtgagcacca
     1681 ggtgctcggc accggcaccg gcgagccagc gggcgacgtg cccgcccagc gcccccgtac
     1741 cacccgtgat gagcacggtg ccgcgcggcg accactggtg tccggcccgg ccgtcgcggc
     1801 gggcggcgct acgggtcagc ctgcggccga acactccacg ggcgcggatc gcgacctggt
     1861 cctcggccga ctggccgagc accgcggcaa gacggccggc gacccggtcg tcgacggtct
     1921 ccggcaggtc gaccagacca ccccagcgcc gggcgtgctc caaggcgagg gcgcggccga
     1981 agccccccac ctggttctgc acagcgctgg gcggtgcgtc gtccgaacgg ccggtgaccg
     2041 ccgcgccccg ggtggcgcac cacagcggcg cgtcgatgcc cgcatcgccg agcgcctggg
     2101 ccagtgccac ggtctgcgcg aggccgcggg agagcgcggg gtgctcgggc ggggcgttct
     2161 cgtcgatcgc gagcagcgac aggatgccgg caagtgatcc ggcttcggcc gcgccccggg
     2221 tcaactcggc ggccagggac tcgcggtcgg cgtccgcgcc gaccgtcagc gggatcaggc
     2281 gcgcgccgcg tccggcgagt gccgcgcgga ccgtcccggc ccacccgtcg ccctcgggcg
     2341 cggcgaacag ccaggtgctg ccggagaggt cgccggagac caggcccttc agcggctgcc
     2401 aggtgagctg gtagcgccag ccgtccacga cggcctgctc gcgccgctgc cgacgccagg
     2461 cggacagctt cgggaccacg acgtccagtt cttcggcgct cagccccagc gtggcggcga
     2521 gcgactcggc gtcctcgcgc tcgacgctcg cccagaactc ggcgtcgacc gcgtccacga
     2581 gggccgcctc ggcctccggg gcatccagcc agtagcgctg ctgctggaag gcgtaggtgg
     2641 gcaggtcggt cttccgtgca ccggggaaga gcgccttcca gtccggggag acgccgtgca
     2701 catgcagttc ggcgagcgcg gcggtgacgg cctgctgctc gggacggtcg gcacgcagta
     2761 cgggcacggt gacgacgtcg tcgtcgaggc agccctgcgc cagggcgctg aggacgccgc
     2821 cggggccgat ctcgacgaag gtgctcacgc ccaggtcgtg cagggtctgc acaccgtcgg
     2881 cgaagcgcac cgcctcgcga acgtggcgga cccagtactc cggcgtgtac gactcggcca
     2941 gacggccggt caggttcgag accaccggaa tcagcggctc gctgaaggac agaccgcgga
     3001 cgacctcggc gaaatcctcc agcatcggat ccatcaacgg cgagtggaac gcatgactga
     3061 ccttcagccg ggacgtctta cgaccctggc cggtgaacac ctcggcgatc gcggtgaccg
     3121 cgtcctcggc accggaaatc accacggact ggggcccgtt gaccgccgcg atacccacct
     3181 gctcggtgag atgcgccagc acctcgtcct cggtcgcctg cacggcaacc atcgcaccgc
     3241 ccgcaggcag cgcctgcatc aacgcagcac gcgccgacac caacctcgcc gcatcctcaa
     3301 gcgacagcac accggccaca tgagcggccg cgatctcacc cacggagtga cccgccacgt
     3361 aatccggccg cacgccccac gactccagca gccggaacaa cgccacctca acagcgaaca
     3421 gcgcaggctg agtacaaccg gtccggttga gctcctcgga gtcgacgtcg agcgtgacat
     3481 cgaggtgggc gcggacctcg tcgtaggccg cggcgaaggc cgggaaggcg ttgtagagtt
     3541 cgcgtcccat accggcccgc tgcgagccct ggccggagaa caggaacccg gtcttgtccc
     3601 cgaggcggcc cgtactccgg aacacggccg ctgacggggt gcccgacgcc agtgaccgta
     3661 ggccttcggt taattcctcc aggctctcgc cgacgacggc cgcccgccgg tcccaggcgg
     3721 cgcgcgtcgt ggcgagggag aagccgatgt cggccggcga ccggccgggg ccgctctgca
     3781 ggaaggcgag caggcgctcg gcctgggccc gcagcgccgc gtcgctcttg gccgagagca
     3841 cccacggcag cgcccccgcg gcggtggcct cgatggtctc ctcgtcgagg gcaggggcct
     3901 gctcgatgat cgtgtgggcg ttggtgccgc tgacgccgaa ggaggagacg gcggcacggc
     3961 gggggtggtc cgactcgggc cacgggacgg cctcggtcag cagcctgacg ccgccggccg
     4021 tccagtcgac ctgggtggtc ggctcgtcga cgtgcagcgt ctgcggcagc acgccgttgc
     4081 ggatggccat caccatcttg atcacaccgg cgacaccgga agccgcctgc gtgtgcccga
     4141 tgttggactt gatggacccc agccacagcg gctggtcacc cgagtgctcc tggccgtacg
     4201 tggcgagcag cgcgtcggtc tcgatcgggt cgccgagggt ggtggccgtg ccgtgcgcct
     4261 ccaccgcatc gacctgggag gcggtcagcc gtgcgttctc cagcgcctgc tggatcacgc
     4321 gcacctgcga cgggccgttc ggggcggtca ggccgttgga cgcgccgtcc tggttgacgg
     4381 cgctgccgcg gatgacggcg agcacgtcgt ggcctagccg gcgggcgtcg gacagccgct
     4441 ccagcaggag cacgccgact ccttcggaca tgcccgtgcc gtcggcggtc gaggagaacg
     4501 cgcggcagcg gccgtcgggc gacaggccac gctgcgcgct gaacgcgatg aacgtgttcg
     4561 gcgtggccat cacggtcacg ccgccggcga gggcgagcga gcactcgccg cggcgcagcg
     4621 cctgggtggc caggtggagc gccaccagcg aggacgagca ggccgtgtcg acggtgaggg
     4681 ccgggccttc gaggccgagg gcgtacgaga tgcggccgga gaccacggcc gcggtgttcg
     4741 cggtgacgag gtgggcctcg atgtcgctgt cgccctgccg ctggaggtag gcgtggtcct
     4801 ggccgttggt gccgacgaac actccggccc gggtgccccg tgcggtggcg gggtcgatgc
     4861 ccgcgcgttc gaaggcctcc caggaggtct gcaggagcag cctctgctgg gggtccatga
     4921 ccagggcctc gcggggggag atcccgaaga acgcggggtc gaagtcggcg gcgtcgtgga
     4981 ggaagccgcc ctcgcgcacg tacgtccggc ccgtccgccc ggggtcgggg tcgtagatcg
     5041 cgtccaggtc ccagccgcgg tcggcgggga actcggtcac ggcgtcgccg cccgaggaga
     5101 ccaggtgcca caggtcctcg ggcgagctga cgccgcccgg gtaacggcag gccatcccga
     5161 cgacggcgac gggctcggtg tccttcgcct ccagctcacc cagctgcctg cgggtgtggc
     5221 gcaggtccac cgtcacgcgc ttgaggtaat ccctgagctt gtcgtcgttc gacatgtttt
     5281 acgtcctctg tagcagtgcg tgagaagagt cagagagacc cgagctcttg gtcgatgagg
     5341 tcgaacatct cgtcgtcggt ggcggcgtcg atccggtcga agtcgcggtc ggtgccgggg
     5401 ccggcgtcgg cggagttggc cgcggtgtcc tgctggatgt cggtccactt ccagagcagc
     5461 gccttgagcc gggcggtgac cttgtcccgt accgcgtcct gcaggtcgag cgcggcgagc
     5521 tgggcttcca gccggtccag ttcgtcgagc accggcgggg ttgcggcgcc gaggtcgagg
     5581 accaggtcct tgtgcaggag ccgggcgatc gcgaccgggt tggggtggtc gaagacgagc
     5641 gtggacttga gccggagccc ggtcgcggcc ttgagccggt tgcggagctc cacgctggtc
     5701 agggagtcga agccgatgtc ccggaaggcc gtggtgggtt cgatccgggc cgcagtggcg
     5761 tggcccaggg cggcggccgc ctggttgcgg accaggtcca gcagcacctt ctcctggtcg
     5821 gcctccggca tcccggcgag gcggcgggcc agggcggggg tgccggcggc cgcggccccc
     5881 tcggccgtgc cgcccgtgtc gccgacgagg ccgcggaaga ccgcgggcat catgccggcg
     5941 cgggccatgg agcgcagccc cgcgacgtcc agccggaccg gcacgatcac cggccggtcc
     6001 gcggtgaggg cgacgtcgaa cagtgccagc ccctccgcgg aggtgaacgg cacgactccg
     6061 gcccggccca tgcggttgcg gtcggcgtcg gtgatccggt cgcccatgcc gccgttgtcc
     6121 gtccacaggc cccatgccag cgaggagccg ggcaggcccg cggcccggcg ctgccgcgcc
     6181 agcccgtcca ggaaggcgtt ggccgctgcg tagctcgccg cgcccgcgct gccgaggact
     6241 ccggcgaggg aggagaagag cacgaacgcg gagaggtcca ggtccttggt cagctcgtgc
     6301 aggtgcagcg ccccgtcggc cttcggccgc agcacggtgt ccaggcgctc gggggtcagc
     6361 gcggtgatca cgccgtcgtc cagggcggcc gccgcgtgca ccacggccac gagcgggtgc
     6421 tcggccggaa ccgaggccag gagctccgcg agggcgtccc ggtccgcgat gtcgcaggcg
     6481 gccacgtcga cgtgcgcgcc gagctcggaa agggcggcga cgacttcgcc gatgccttcg
     6541 gcggcggggc cgcggcggct gaccatgagc agcctccgtg cgccgcgttc cgccacgagg
     6601 tgccgcgcca acaaccgtcc gaggccaccg gtcgcgccgg tgagcagcac ggtcccttcg
     6661 gggtcccacg cgtgatcggt gggctcctct gacggggcga tccgggcgag gcgcggtacg
     6721 aacagcttgc cgtcgcgcac tgcggcctgc ggctcgtcga gggcggcgag cgccgccacc
     6781 agcgcggggt cgacacctcc gtccgcgacg aagtcgtccg cgtcgacgag caggagccgg
     6841 tccgggtgct cggactgggc cgacttcacc aggccgacca ccgcgacgtg tgcgaggtcc
     6901 ggcgccgctc cgtccaggtc gacggctccg cgcgtcatca ccacgagccg cgcatcggag
     6961 aaccgctcgt cggcgaccca cttctggacg gccgacagca caccggccag caactcgcgt
     7021 gtggccgagg cggcaccgct ctcgctcggg gcgcagggca ggagcacatg ggcgggcggg
     7081 gccgcaccgt cgtcgaccgc ctcacggagc gcgtcgatgt cggcgtaggg gccgtcgccg
     7141 ccgagaaccg cccactcggc ctcgggagcg gaagcagcag gggcggtgtg ctcgacccag
     7201 tcgacctcga acatccagtc ctgctgcgcg acgcgcgacg caagcaactg ctgcggagac
     7261 accgtccgcg tccgcaggga ggccaccgag gcgacaggag caccgtcggt gtcggccagt
     7321 tcgatcgcca ccgcgtcgcc ggcagcgggc cggatccgta ggcgcacgtt cgctgctccc
     7381 ggggcgtgca cggacgtgcc gctccaggcg tagggcatga gcacccggcc gggatcgccg
     7441 gcaccgtcga gcgccagggt gtccaggacg gcgtccagca gtacggggtg caggcggtag
     7501 ccgtccgccc ggtcccgctc cgcgagaggc agcgcggtct cggcgtacag ctcgtccccg
     7561 gcgcgccagg cggcgcgcag gctcggatgg ttctcgacgt ccaccggctc ggcgcccgcc
     7621 ggcggccaga tcaccatatc gaactccgcc gccggagcac tgcgggtgag ttctccggtg
     7681 acgtggcaga cccacgcctc gtcggcgcct ccggcggcgg cccggctgaa gaccctcacc
     7741 gaccgccggt cggtgtcgtc gcccgcgccg acctggacct ggatgcggac ggcgccctgt
     7801 tctgccagga ccagcgggac gtccatgtcg agctgttcca gatgcgggaa cccggcctgc
     7861 cggcccgcgc ccagtgcgag ttccacgaac gcggcggcgg ggagcaccgg caccccgccg
     7921 accgtgtgtt ccgcgatcca gggcgtgtcg gccggggaca gccggccggt gaacagcacg
     7981 tcctgtcccc cggcggtctc caccaccgcg ccgagcaggg ggtgaccgga ggagtccagg
     8041 cccgccgagg agacgtcggg cgcgaccgtg ccttcgagcc agtagcgctc gcgctggaag
     8101 gcgtaggtgg gcaggccgac gcggcgagcg ccggggaaga gcgcctgcca gtccggggag
     8161 acgccgtgca cgtgcagttc ggcgagcgcg gcggtgacgg cctgcggttc ggggcggtcg
     8221 gtgcgcagta cggggacggt gacgacgtcg tcgtcgaggc aggcctgggt gagggcactc
     8281 agcacaccgc cgggaccgac ctccacgaag gtgctcacgc ccaggtcgtg cagggtctgc
     8341 aggccgtcgg cgaagcggac ggcctcgcgg acgtggcgga cccagtattc gggcgtgtac
     8401 ggctcggcga gacggccggt caggttggag accaccggaa tccggggctc gctgaaggac
     8461 agaccgcgga cgacctcggc gaaatcctcc agcatcggat ccatcaacgg cgagtggaag
     8521 gcgtgactga ccttcaaccg cgacgtctta cgaccctggc cggcgaacac ctcggcgatc
     8581 tcgacgaccg catcctccgc cccggagacc acgacagact gcgggccatt gaccgccgcg
     8641 ataccggtct gcccggtcaa gtgcgggagc acctcgtcct cagtgccctg gatcgccacc
     8701 atcgcaccgc ccgcaggcag cgcctgcatc aacgcagcac gcgccgacac caacctcgcc
     8761 gcatcctcga gcgacagcac gcccgccaca tgagccgccg cgatctcgcc cacggagtga
     8821 ccggccacgt aatccggccg tatgccccag gattcgagga gccggaacag cgccacctcg
     8881 acggcgaaca acgcgggctg ggtgcacccg gtccggtgaa gcgtttcagc atcgacatcg
     8941 accggcgcgt ccagccgcgc acacacctcg tcataagccg cggtgaacgc ggggtacgcc
     9001 tcgtacagct cgcgccccat gccgaggcgc tgcgaaccct gccccgagaa caagaacccg
     9061 accttgcccc gggcggcatc ggcgcgcccc gtcaccacat gcgccgcggg attgcctgct
     9121 gcgagtgcgg tcagccctgc gcgcaactcg tcctcgtcgg cgccgaccac cgcagcccgg
     9181 tgctccagtg ccgaccgggt ggccgccagc gagaacccca cgtcggccgg cgacgcggcc
     9241 gcgaggtcca cggacgacag cagccgctgc gcctgctcgc gcagcgcctc gccggtcttc
     9301 ccggagagca cccacgggag caccgaggtc cgcggccgca gcggctcgtc ggccgccgca
     9361 cctccacccc cggccgtgtc gtcggccggt tcctccgccg cccgttcggt cgcctgctca
     9421 aggatgacgt gcgcgttggt gccgctgatc ccgaacgagg agaccccggc ccgacgcggg
     9481 tggtccgact ccggccacgc ggccgcctcg gtcagcagct cgaccgagcc ggccgaccag
     9541 tcgacctgcg gggtcggccg gtcgacgtgc agcgtccgcg gcagcactcc gtgctgcatc
     9601 gccagcacca tcttgatcac gccggcgaca cccgccgcag cctgcgtgtg gccgatgttc
     9661 gacttcagcg agccgagcag tagcggccgt tcgcggtctt gcccgtaggt cgccagcagc
     9721 gcctgcgcct cgatcgggtc gccgaggttc gtgcccgtgc catgtgcttc gacggcgtcg
     9781 atctcctcgg cggacagccc gccgtcggcc agcgcctcga ggatcacacg ctgctgcgaa
     9841 ggaccgttcg gcgcggtcag accgttggac gcgccgtcct ggttcaccgc gctgccccgg
     9901 acgacagcca gcacccggtg gccgagccgg cgggcgtccc gcaggcgctc gaccagcagc
     9961 agcccggcgc cttcggacca tgacgccccg tccgcggccg ccgcgaagga cttgcagcgg
    10021 ccgtcggagg cgaggccgcg ctggcggctg aactcgacga acgcgctcgg acccgccatg
    10081 accgtcacac cgccggcgag cgccatggag cactcgccgc tgcgcagtgc ctgcacggcg
    10141 aggtgcaggg cgacgagcga ggacgagcag gcggtgtcga tggtgaccgc ggggccctcg
    10201 aagccgaagg tgtaggcgat gcgcccggag gcgacgctgc cggagttgcc ggtgctgagc
    10261 agcccttcga cgccgtcggg gaggacgccg ggcgtgaagc cgtagtcgtg gtacatcagg
    10321 ccggcgaaga cgccggtgcg gctgcccttg aggggagcga ggtcgatgcc cgcgtgctcg
    10381 aaggcctccc atgcggtctc cagcagcagc cgctgctgag ggtccatcgc cagggcctcg
    10441 cgcggtgaga tcccgaagaa gtccgcgtcg aagtccgccg cgtcgtggag gaatccgccc
    10501 tgccgggtgt agaccttgcc cggctgctcg gggtcggggt cgtagagcga gtcgacgtcc
    10561 cagccgcggt cctcgggaaa ctgcgagatc gcgtcgccgc cctcggccag cagccgccac
    10621 agcgcctcgg gggagccgat gccgccgggg aaccggcagc tcatgcccac gatggcgatc
    10681 ggctcctggt cccgggcctc cagttcgcgc acgcgccgcc gggcctggcg caggtcggtg
    10741 gtggcccgct tgaggtagtc ccggagcttt tcttcgttca tcatcggtgt tgcccgcccc
    10801 ttttggcctg cgcagttcag gagatgccga gttcgccgtc gaggagctcg tacagctcct
    10861 cgtcgctcgc cgagctgagg tcgtcttcgt cctcggctcc gccggcgcct cccggatcgg
    10921 ccggctcgtt cccgttccag cgggcgagca gcgcctggag acgcatgttg atcttgattc
    10981 gggtgatgtt gccgacgctg tccgctccgg cgccgtcgag ggcggcggcg aggcggtcga
    11041 tctcgtcgaa caccgacacc gtcccgcccg tgccgccggg gaggtccttc agcaccctct
    11101 gagcgagcgc cgtcggcgtc gggtggtcga agaccagcgt tgcgggcagt cgcagcccgg
    11161 tggccttgtt catccggctg cggaactcca cggcggtcag ggagtcgaag cccaggtcgc
    11221 cgaaagcctg gtcgggctgg accgacttgg cagagctgtg cccgaggacg gcggcgacct
    11281 cggaccggac caggtccagc accacctctt cgcgttcgct ctccggcagg tccgcgaccc
    11341 gctgcgccag cggtacggcg gctgcccggt ccgtacgccg cggccggccg ccgaccagcg
    11401 tcctgagcag cggcggcacc ggggcggccg cgttccgcag ggcggcgatg tccacccgtg
    11461 ccgccaccac taggggctcc tccagcgcga gcgcggcgtc gaggagttcc aggccgtcct
    11521 catcggacag cggcacgacg ccgccgcggg cgagccgggt ccggtccact ccgccgaggt
    11581 cctcggtcat ggtgccggtc cgctgccaca ggccccacgg cagcgacacc gcggggagtc
    11641 cctgcgcacg gcggcgcccg gcgaaggcgt ccaggaaggc gttggcggct gcgtagttcg
    11701 cctggccggg ggtgccgagc gtgcccgcga gcgaggagaa gacgacgaac gccgatacct
    11761 cgcccgtcag ctcgtgcagg ttcagcacgg cgtcgacctt ggggcgcagc accgcgtcca
    11821 ggcgctccgg ggtgagcgaa ccgatcacgc cgtcgtcgag gacaccggcc gtgtggacca
    11881 cggccgtcac cggcatcccg gcgagtgccc cggcgagggc gtcgcggtcg gccacgtcgc
    11941 aggcggccca gtgcacttcg gcccccgagg cggcgagctc cgcccggagc tccgccgcac
    12001 cctcggcgtc cgcaccgcgc cggctcatca gcagcaggct gcgcacgccg tgctcggcga
    12061 ccaggtgccg ggcgacgagt ccacccaggg cgccggacgc gccggtcagg agcaccgttc
    12121 cggttccgaa gtccggggcg ccctgcgggg cgtcggcggt ggctctggcg agccggggca
    12181 gaaggagcgt gccgccgcgc agggccgcct gcggctcctc ggaggcgagg agccggggta
    12241 cggccgtcgc cacggcctgc tgccagtcgg tgtcccggtc ggtgttctcg tcggtgtcga
    12301 ggaggacgat gcggtccggg ttctcggact gcgccgaccg caccaggccc cacacggcgg
    12361 cctgtgccgg atccgccggt gccgggtcgt cgccggcggc gactgcgccc cgggtcacga
    12421 gcacgaggcg ggcggcccgg tcctcggcca gccacacctg caccagcccg agcacctcgg
    12481 ccaggacctc ccggacccgc tcggcctcgg agcccgaacc ggcggggcag ggcacgacga
    12541 cggcgtcgac ctccgcctcc gccccgggct ccgtctccgg ggcgcggagg agcaaggcga
    12601 tgtcgtcgta ggcgcgtacg gccgggccgt tcgcctcgga cggcgcggcg agcggcgccc
    12661 actccacggt gaacagggag tcccgggagc tcgtacggag ctggtcggcc gacaccgggc
    12721 gcagcgtcag cgattccacc gagacgacgg gccgacccgt gccgtcggcg gcctccagcc
    12781 gtaccgcgtg gccgccggcc tgcgagagcc gtacccgcag ggcggccgct ccggttccgt
    12841 ggaccgtgac gcgggaccac gcgaagggca gcaggggccc gtcggctgcc ggtacgagcc
    12901 cgcccgcgcc cagcgcgtgc agggcggagt cgagcagggc cgggtgcaca ccgaacgcgt
    12961 ccgcgtcggc gtgtgcttcg tcggggacgg ccagttcggc gtagaccgcg tcgttgccgc
    13021 gccaggcggc gcgcagcccc cggaagagcg ggccgtagct caggccgagg tccgccagcc
    13081 ggtcgtagaa gccgtccagg tccaccggcc gcgcgtcggc cgggggccag ctgctcaggt
    13141 cggtcccgga aggggtccca ccggtggcga gggctccggt ggcgttgcgg atccaggggc
    13201 cttccccggc gcgcgagtgc acgctcagcg ggcggcggcc ggagtcgtcc tgggcgccca
    13261 cgaggacctg gatctggacg ccgccgtgct cgggcagcaa cagcggtgcc tgcagggtga
    13321 gctcctcgac caggtcgcag ccggtctcgg ccgcggcgtg ggcggccagt tcgacgaagg
    13381 ccgtgccggg cagcagcacc gtgcccagca ccgcatggtc ggccagccag ggctgggcct
    13441 gcagcgacag caacccggtc agcaggtggc cgccggcgtc gggcagttcc accgccgcgc
    13501 ccaggaacgg gtggtcggca aagtccagtc cggccgcccg tacgtcgccg gcgggcgcgc
    13561 ccgcttccag ccagtaccgc tcgtgctgga acgcgtacgt cgggaggtcg acgcggcggg
    13621 caccgggcag gacggcgttc cagtcgatgg cgacgccgtg cgcgtgggcc tgggcgaggg
    13681 acagcagcag ccggtgccgg ccgccgtcgc cgcggcgcag cgtcggcacg accacggcct
    13741 cggcctcggc ggcctcgatg gcgtcctgga taccggccag ttgcacgggg tgcgggctga
    13801 cttcgacgaa cacgtcgtgc ccgtcggcca aggcggaccg gatcgcgtcg tggaaccgca
    13861 ccgtctgccg catgttgcgg taccagtagc cggagccgag ctcgcccgca tccagctttc
    13921 cgcccgtcac cgtggagtag aagggcacgg tgccggggag ggggccgata ccggcgaacc
    13981 cctcgccggc ctgcgtttcg acccgttcga tctgcggcga gtgcgcggcg tagtcgacgg
    14041 cgaccttgcg ggcctggatg ccctccttcc cgcagtacgc gaggagttcg tccagggcgt
    14101 cggtgtcgcc ggagaccacg acggtgccgg gcccgttcac ggcgccgatg tcgaggcggc
    14161 cggcccaccg gccgaccagt acctgtactt cctcttccgg gagcgtcacc gagaccatgc
    14221 cgccgcggcc ctggagttcg cgcacggcga ggctgcgctg cgccacgatg cgcgccgcgt
    14281 cctccaggga gaccgctccg gcgatcaccg ccgcggagac ctcgccctgg gagtgtccga
    14341 cgaccgcgtc gggggtcacg ccgaaggagc gccacacctc ggccagcgcg accgtcatcg
    14401 cccacagcac gggctgcaga acgtcgaccc ggtcctgctc gacatcggat gcgccgcgaa
    14461 gcaccgcggt cagcgaccag tccacgtgcg gcgcgagggc gcgctcgcag gcgtcgatcc
    14521 ggtcgcggaa gacctgcgag gtctccagca gttcggcggc catgcccgcc cactgcgacc
    14581 cctgtccggg gaagacgaag acggtcttgc cgccggcgcg tgcggtgccg gtcaccacgc
    14641 cgggcggcgt ggagccgtcc gcgacggcgg ccagcccctg ccggagctcc tcgggggtgt
    14701 ccgcgaccac gacggcgcgg tgttcgaagg ccgccctggt cgtggccagc gaatacgccg
    14761 catcggccgc ggtggccgca acgtcgccgt cggtgtcggt gtccgccagg aaggaggcga
    14821 ggcgggcggc ctgcgcccgc agggctgctt cggtcctgcc ggagagcacc catggcacga
    14881 gcgtgccgga gtcgggcgtg ggcggcggct ccgccgtcgc gggtgcctgc t
//
