LOCUS       NZ_BMWB01000036        23401 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence36, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000036
VERSION     NZ_BMWB01000036.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 54734)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 23401
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000036.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23401
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23401
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23401
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[5113:13401]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5114..13401
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(101..226)
                     /locus_tag="IE198_RS36240"
                     /old_locus_tag="GCM10010381_65440"
     CDS             complement(101..226)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS36240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_65440"
                     /product="hypothetical protein"
                     /protein_id="WP_268246518.1"
                     /transl_table=11
                     /translation="MRADGTWNAVGASTVRPARALTVMEQEIATLVQELPGILDG"
     gene            complement(223..1134)
                     /gene="argB"
                     /locus_tag="IE198_RS32150"
                     /old_locus_tag="GCM10010381_65450"
     CDS             complement(223..1134)
                     /EC_number="2.7.2.8"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003991 - acetylglutamate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187682.1"
                     /locus_tag="IE198_RS32150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65450"
                     /product="acetylglutamate kinase"
                     /protein_id="WP_189893070.1"
                     /transl_table=11
                     /translation="MGTPVDQDVAGADPTVGDLPWLEELQGRTVVVKFGGNAMVDPSLH
                     RTFAQDVVELWHAGLRPVVVHGGGPQISAMLDRLDLEVRFEAGLRVTTPETMDVVRMVL
                     TGQVQRELVGAINAHGPFAVGLSGEDAHTMTAERRPAWVDGQPVDIGLVGDIVSVDAAT
                     VRTLLEQGRIPVVSPIARGADREVYNVNADLAASALAVALGAERLVVLTDVEGLYADWP
                     HSTQVVERLTAAELDGLLPELASGMLPKMEGCLRAVRAGVGRAHVLDGRVPHAVLRGVF
                     SEKSPGTTVVPDTLPVGEGAGA"
     gene            complement(1152..1451)
                     /locus_tag="IE198_RS32155"
                     /old_locus_tag="GCM10010381_65460"
     CDS             complement(1152..1451)
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014065.5"
                     /locus_tag="IE198_RS32155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65460"
                     /product="bifunctional ornithine
                     acetyltransferase/N-acetylglutamate synthase"
                     /protein_id="WP_189893072.1"
                     /transl_table=11
                     /translation="MTVTAAQGFLASGVAAGIKESGEAEFADAAPAVCLDLDVAINDVR
                     GCRDGAAGPSRDKPNMSQRRITVTVGLRAGEDPAVVRTDDLTAEYVHENSTYSS"
     gene            complement(1448..2488)
                     /gene="argC"
                     /locus_tag="IE198_RS32160"
                     /old_locus_tag="GCM10010381_65470"
     CDS             complement(1448..2488)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070401 - NADP+ binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016639241.1"
                     /locus_tag="IE198_RS32160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65470"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_189893074.1"
                     /transl_table=11
                     /translation="MTVRVAVAGASGYAGGELLRLLSSHPEVEIGAVTAHSSAGHRLGE
                     LQPHLPALADRMLESTSADVLRGHDVVFLALPHGESAPLARGLEEDSLVLDCGADFRLR
                     DAAAWTRFYGSPHAGTWLYGLPELPGARAELPGARRIAVPGCYPTAVTLALMPAYAARL
                     VEPEAVIVAAGGTSGAGRAVKPQSLASEVMGSMSPYGVGGGHRHTPELTQNLSRLAGER
                     VTVSFTPTLAPMSRGILATCSARLRPAVSGKDAPDRVRAAFEEAYADEPFVRLLPVGRW
                     PSTGSVVGSNTALVQVAVDQDAGRLVCVSAIDNLVKGTAGGAVQCMNVALGLPEPLGLP
                     TNGVAP"
     gene            complement(2552..3208)
                     /locus_tag="IE198_RS32165"
                     /old_locus_tag="GCM10010381_65480"
     CDS             complement(2552..3208)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044554.1"
                     /locus_tag="IE198_RS32165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65480"
                     /product="isochorismatase family protein"
                     /protein_id="WP_189893077.1"
                     /transl_table=11
                     /translation="MALPTIESYPMPERSALPASCASWTVDPDRCALLVHDMQNHFVRA
                     FPPGLPPVVELVRNIAALRELAGALGIPVFFSAEPAAQQPGQRGLVADVWGPGIGDEAD
                     AAAIVGPLLPRPGEHVLANVRHNAFLRSHLGRLLRQENRDQLIICGVHAHLGVLLTAAD
                     AFMNDIQPFVVADAVADFSAEEHATALRWAARSGVVRTTDALLHDLLLHRVPKDA"
     misc_feature    complement(3253..3271)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 30.9"
                     /tool="antismash"
     gene            complement(3283..4002)
                     /locus_tag="IE198_RS32170"
                     /old_locus_tag="GCM10010381_65490"
     CDS             complement(3283..4002)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890446.1"
                     /locus_tag="IE198_RS32170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65490"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_189893079.1"
                     /transl_table=11
                     /translation="MGHGWQGAVLKLMRGKDFTLTVRSNERLSDRLHRLSFSDGGMLRA
                     TGVHPTMWVRLWFDNGGRPHQRAYTLVDPDPAEGTFSMDFALHSGRASDWARAAHPGAT
                     IEATVQGSEFAPPDPPPSRLLVVGDAASRPAIDSLLGSMPLTPATVWYETSHVCDSDHA
                     PRVGTASREVVHVPRRDKGAHLIETVRAALPERVDDASYLWIACDTATTRALASFARKQ
                     LGVPTERLHALGYWRAT"
     misc_feature    complement(4027..4045)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 31.19"
                     /tool="antismash"
     gene            <4064..4386
                     /locus_tag="IE198_RS32175"
                     /old_locus_tag="GCM10010381_65500"
                     /pseudo=""
     CDS             <4064..4386
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324499.1"
                     /locus_tag="IE198_RS32175"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GCM10010381_65500"
                     /product="transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="TLPLEVLAAALAERGIPVRTFGGALPVESLVAAVHRTGPAAVGSW
                     AQSRTTASRPLAQHVAAMEWGCAVPAGSRSS"
     gene            4689..5117
                     /locus_tag="IE198_RS32180"
                     /old_locus_tag="GCM10010381_65510"
     CDS             4689..5117
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS32180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_65510"
                     /product="hypothetical protein"
                     /protein_id="WP_189893081.1"
                     /transl_table=11
                     /translation="MNIYGARVPVAGATGVLGGERTAEVAGRGARTALAGRDSRRLPRA
                     AQAPSRAAPSAGLHAVRREARGDGVGVPDVRPGHLNTCSADRPMVGTALPLLPGGDPRQ
                     VAATVADAPATDADAPATDAEVLRTAPNGTPVVERRAR"
     misc_feature    4690..4706
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.87"
                     /tool="antismash"
     gene            5114..6337
                     /locus_tag="IE198_RS32185"
                     /old_locus_tag="GCM10010381_65520"
     CDS             5114..6337
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018843432.1"
                     /locus_tag="IE198_RS32185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65520"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_229834679.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.9e-99, bitscore:
                     324.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRGPAPSARTSEVVVVGGGAAGLSLAHRLTETGAATVTVVEPPD
                     GPLRPPERTWCYWDHGTGDFDEAVTASWSRLRIHGADGGEFTVDPAPLLYRMLRSAPFE
                     RLVHSRLARSPGGHVLRATAEAVRNVSGGAEVLCTEPDGRTLTLRARHVFDSRPLPALP
                     PARTQLLQHFRGWFVRTAAGRFDPAVADLMDFRVPQPRHGLAFGYVLPLAPDRALVEYT
                     EFSRTALTTAAYESALGHYSRDILDLGAFTVEAAEQGVIPMTDARFPRRLGAAVFRIGT
                     AGGATRPATGYTFAAVQRQSKAIAAALRDGRGTVPPPHGRRALAMDAVLLRALDTGRID
                     GPAFFTDLFRRTPAERLLRFLDGATSPWEEWGIGLRTPVGPMLRTAVELPFLPRRSRTA
                     PRIGESTR"
     gene            6334..7065
                     /locus_tag="IE198_RS32190"
                     /old_locus_tag="GCM10010381_65530"
     CDS             6334..7065
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566149.1"
                     /locus_tag="IE198_RS32190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65530"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_189893083.1"
                     /transl_table=11
                     /translation="MTLLRDHDLARAFDHASHTYDRLTALNPGYRTDLLRSARRLRLPG
                     EGAGLHVLDLGCGTGTSTRALLRAAPRARITAVDASSGMLRRALDKPWPAGVRFLHLTA
                     EAVATAGEGPFDAVFAAYLFRNVTDPDRVLAAVRTQLRPGGRLAVHEYCLSGSPVHRAL
                     WTAVCQGVVIPAGTLSGDRGLYRHLWHSVLDFDTAPAFTDRLTRAGFTGVRAVPVAGWQ
                     TGIVHTFLARNACADAAGCAR"
     gene            7062..8630
                     /locus_tag="IE198_RS32195"
                     /old_locus_tag="GCM10010381_65540"
     CDS             7062..8630
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329055.1"
                     /locus_tag="IE198_RS32195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65540"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_189893084.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-08, bitscore:
                     26.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 9.6e-13, bitscore: 39.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARPSGTARRGRDRKAEVLMPAPGRNRFEYGDAPSVAVVGGGIA
                     GLAAATLLAERGARVTLYEQEESLGGRLAGRRTRLADGSVATMSRGFHAFFRQYYNLRG
                     LLRRTDPALTRLTPLPDYPLRHSGGLTDSFARVPRTPPFSALGFVALSPTFGWRDLATM
                     DARAALPLLDVRVPEVYERFDGITATSFLEAVRFPEAAHHLAFEVFSRSFFADPRELSA
                     AELLLMFHIYFLGSAEGLLFDVPNDPFPQALWEPLGDYLQRLGTAVRTGSPVHGVHPRD
                     AGGAEVRTDTGVDRHEAVVLALDTEGLRRLVAASPGLGTAAWRDDVAAVRTAPPFLVSR
                     LWLDRPVCATRAGFLGTSGYGGLDNISVLERYEGEAARWAARNRGSVVELHAYAVAADA
                     ESEKVQNRLVEQLQQVYPETRQARIVDVRHEWRSDCPLFAVGSHHRRPTVRTPHPWLTL
                     AGDAIRCDLPVALMERAATTGFLAAGALLAAWGIRGQVLWTVPRAGRSPALRALGALVA
                     RRARA"
     gene            complement(8709..9716)
                     /locus_tag="IE198_RS32200"
                     /old_locus_tag="GCM10010381_65550"
     CDS             complement(8709..9716)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524373.1"
                     /locus_tag="IE198_RS32200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65550"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_229834680.1"
                     /transl_table=11
                     /translation="MSDRADRTRWTSPLRRRRGPEWAAQSPTWREARPALISDALKRAC
                     ARRSGNWFVVGASRDVRAGGRPCGRTVGGVEVVLWRSDTGELRAGPGACPHLGAPLRDS
                     RVVCGRLVCHWHGLALDGSPFAGWTPYPVHDDGVLVWVRLDTVGGEEPSQRPVVPVRPT
                     TGSRVDAVFTTVGRCEPQDVVANRLDPWHGSWFHPQSFVDLTVVREPQGDDDDAFVVDV
                     SFLVAGRLVVPVRAEFTAPEPRTVVMRITQGEGATSVVETHATPLTGAADERPRTAVVE
                     AVVATSDRRGFALARAAAPALRPLMRCTAGRLWRDDLAYAERRWALRSTGRFPG"
     gene            complement(9709..10713)
                     /locus_tag="IE198_RS32205"
                     /old_locus_tag="GCM10010381_65560"
     CDS             complement(9709..10713)
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566146.1"
                     /locus_tag="IE198_RS32205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65560"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_189893086.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-125,
                     bitscore: 409.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.7e-64,
                     bitscore: 209.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAAGITDPSLRAAYSRCRGLNARHGRTYFLATRLLPLER
                     RSAVHALYGFARWADDIVDALDRRRAPEERDRLLHCLESDLAHGLRTGRGDEPVVRAVA
                     DTADRYDIEPTLFADFLASMRADLTVTDYPTYADLQSYMHGSAAVIGLQMLPVLGTVVP
                     RDEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRPLLEWSRRTGRR
                     DPRIRAALVAAEAMTRDVYRAAEPGIAMLDPRVRPCIHTAFTLYGGILDAIAGHDYTVL
                     HHRAVVSRGRRAATAAAGAVHVLGARWRARAPRPAPVASGTARHSSGRDTGSE"
     gene            complement(10700..12265)
                     /gene="crtI"
                     /locus_tag="IE198_RS32210"
                     /old_locus_tag="GCM10010381_65570"
     CDS             complement(10700..12265)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011026910.1"
                     /locus_tag="IE198_RS32210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65570"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_189893087.1"
                     /sec_met_domain="DAO (E-value: 9.8e-18, bitscore: 56.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVTGPTDHVVVVGAGLSGLACALHLLGAGRRVTVVERDAGPGG
                     RAGRVRLGGYQVDTGPTVLTMPHLADEAFAAVGDSLDHHVELVALHPAYRAAFADGTSL
                     DVHTGGEAMEAEVRRFAGPTEAAGYRRLRDWLQRLYRAQIRRFIDTNFDSPLPLLHPDL
                     ARLAALGGFGRLDHQIGRFLSDARLRRVFSFQALYAGVAPARALAAYAVIAYMDTVAGV
                     WFPKGGMHALPRAMAAAAADAGAHLRWSAEVSTLERSADRVRAVHLASGERIPCDAVVL
                     SCELSAAHRLLGRAPRRPVRLRHAPSAVILHAGTDRTWPGLAHHTLSFGAAWERTFDEL
                     TRSGALMSDPSLLITRPTAHDATLAPPGRHLHYVLAPCPNTTVGPAAATWRDLGPRYRD
                     SLVDELERRGLDGFAGSIEEELLVTPLDWTAQGHAAGSPFSVSHTFAQTGPFRPRNLVR
                     GLDNVVLAGCGTTPGVGVPTVLISGKLAAARVTGSSERHPARTRPAPAAAPPTPTAAGA
                     DDPS"
     gene            complement(12262..13401)
                     /locus_tag="IE198_RS32215"
                     /old_locus_tag="GCM10010381_65580"
     CDS             complement(12262..13401)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923006.1"
                     /locus_tag="IE198_RS32215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65580"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189893089.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-49, bitscore:
                     160.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGLRPTVAEPAGLVDEPLTALDACRAVETVLGHVLDAGLDRARG
                     VDPVFALDVAGRVAAFVRRGGKRLRSAFAWCGWRAVGGSGDATAVVHTGAALELLQACA
                     LIHDDVMDGSLLRRGAPAMHVDLARMHWAARMTGSAESFGTSAAVLAGDLALAWADDLL
                     TETALGSPHGPRLYREWQAMRGEMVAGQYRDLHAQASGSSGVDEALTIATLKSALYTVE
                     RPLALGASLAAAGPSLDALRAAGRCAGLAFQLRDDLLGAFGDPASTGKPVGDDLGSRKL
                     TYLLAVALELADASGDKEAAAVLAPSAGPRPEHTVEHMRRALERTGSRAVVESKIVELA
                     TTSLGHFEATGAEPAVRREFAALVERASCVTPLRTQGDM"
     gene            complement(<13698..15062)
                     /locus_tag="IE198_RS32220"
                     /pseudo=""
     CDS             complement(<13698..15062)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007500172.1"
                     /locus_tag="IE198_RS32220"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="deoxyribodipyrimidine photo-lyase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVAVVLFTSDLRLHDHPPLRAALAAGDEVVPLFVRDPGVRAAGF
                     DAPNRRAFLADC"
     gene            complement(15100..16671)
                     /locus_tag="IE198_RS32225"
                     /old_locus_tag="GCM10010381_65620"
     CDS             complement(15100..16671)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823972.1"
                     /locus_tag="IE198_RS32225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65620"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189893091.1"
                     /transl_table=11
                     /translation="MGTDGQRHTERLHCLVTGASGYIGGRLVPELLGVGHRVRCLARSP
                     GKLRDHPWAADVETVQGDVTDADSVCAAMRGIDVAYYLVHALASGSGFEETDRQAARLF
                     TEQAHAAGVRRIVYLGGLTPRGVPEAQLSPHLRSRTEVGRIFLDGPVPATVLRAAVVIG
                     SGSASFEMLRYLTERLPVMVTPRWVHTRTQPIGVRDVLRYLVGSATMPADVDRAFDIGG
                     PDVLTYRDMMRRYAVVAGLRRRVIVPVPVLTPGLSSHWVGLVTPVPANLARPLTESLRH
                     EVVCHEHDIARYVPDTPGRPLPFDEALTLALRRVREAQVATRWSSAAAPGAPSDPLPTD
                     PDWAGGSLYQDKRQLSVDASRESLWRVIEGIGGDTGWYSFPLAWAVRGRLDRFVGGVGL
                     RRGRRDAEHLRVGDSLDFWRVEEIEPGRLLRLRAEMRLPGLAWLEMCSETDEEGRTRYR
                     QRALFHPRGLLGHAYWWSVSPFHAVVFGGMARNITQAAAKGMRARGTPAQAGRARRPRR
                     ARRVRH"
     gene            complement(17078..19180)
                     /locus_tag="IE198_RS32230"
                     /old_locus_tag="GCM10010381_65630"
     CDS             complement(17078..19180)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004936195.1"
                     /locus_tag="IE198_RS32230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65630"
                     /product="MMPL family transporter"
                     /protein_id="WP_189893093.1"
                     /transl_table=11
                     /translation="MRTTPPWARWLVPLVLLLVWLGVGGTLGPYASKLGEVATNDQAAF
                     LPQSAESTKVLTAREAFDQSETLPAVVVWTADGGQVSERQQAAATRAVDELAGRPGVVG
                     RPSPALLSHDKEAMQAVVQLEPDLGEALPDVLAEVRRTAQGVPDATPQIAGPAASRSEL
                     SDAFAGVDGLLLGVALAAVLLILLLVQRSVLLPFLIILGSVFALGLACAVVYALADRDL
                     VRVDGQVQGILSILVIGAATDYALLLSARFREEFAVRGDRAAAAVAAVRRSFGAITASA
                     ATVALGLLALLASDLTNNRALGPVGAIGIVCAVLSTLTFLPAVLALLGRSAYWPSRPKA
                     SDASGEGHGVWRRVAATVDARPRRTWVVTALALTVFAAFSPSLSAKGVPLDEIFVNDAS
                     SVAAQETLGEHFPGGSGNPAVIIADADRAAQVTAAARSTDGVASAGPVSASGRPTADEP
                     LVVDGRVRIDATLEAAADSDAAKETIQRLREDVHAVSGAEALVGGYSAQQFDTQRTAAA
                     DRTVIVPLVLAIILLILVLLLRSLLVPVLLVATVAVNFLATLGVSALVFEQLLGFSGTD
                     ASVPLYGFVFLVALGVDYNIFLMSRVREEALAHGTRQGVLRGLSTTGGVITSAGVVLAA
                     TFSALMVIPLAFLVQIAFIVAFGVLLDTLVVRSLLVPALVIDIGPRAWWPSALARNGGT
                     GSASGP"
     misc_feature    19213..19227
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 20.1"
                     /tool="antismash"
     misc_feature    19226..19240
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.97"
                     /tool="antismash"
     misc_feature    19235..19253
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.85"
                     /tool="antismash"
     misc_feature    19243..19261
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            19253..19759
                     /locus_tag="IE198_RS32235"
                     /old_locus_tag="GCM10010381_65640"
     CDS             19253..19759
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004936197.1"
                     /locus_tag="IE198_RS32235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_65640"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189893095.1"
                     /transl_table=11
                     /translation="MDGKDDRASSPPEDDSTGLQSFVVLLRGMNGEFNRIAHEFAHAQG
                     LHLTDVQALIAILDTDPAEGPMTPGQLRKQLNLTSGAVTACIDRLEKAGHVRRVRAVDD
                     RRVVHLHYAETARSVAGEYFRPLARCAGIARERFTDEELAVVVRFLTEMNRELVVLRRQ
                     AAPGA"
     misc_feature    20015..20029
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.51"
                     /tool="antismash"
     misc_feature    complement(20023..20037)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    complement(20481..20492)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.72"
                     /tool="antismash"
     misc_feature    20528..20543
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.2"
                     /tool="antismash"
     misc_feature    complement(21204..21217)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    complement(21619..21633)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.32"
                     /tool="antismash"
     misc_feature    complement(21914..21930)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    22729..22744
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.37"
                     /tool="antismash"
ORIGIN
        1 gcctgcataa actactcgcg gcctgatcaa cacgaccacg tgttgcgacg atccctagaa
       61 accgccggac ggctccggcc ccttccgtgt ttcgggcacg tcagccgtcc aggatgccgg
      121 gcaactcctg cacgagggtg gcgatctcct gttccatgac cgtcagggcg cgagccggtc
      181 gcacggtcga cgcgccgacg gcgttccagg tcccgtcggc cctcatgcgc cggctccctc
      241 gcccaccggc agagtgtccg gcacgacggt cgtgccgggg ctcttctcgc tgaacacccc
      301 acgcagcacc gcgtgcggga cgcggccgtc gaggacgtgc gcccgtccga cgccggcgcg
      361 gaccgcccgc aggcagccct ccatcttggg cagcatcccg cttgccagct cgggcagcaa
      421 cccgtccagc tccgcggcgg tgaggcgttc gacgacctgg gtgctgtgcg gccagtccgc
      481 gtacagcccc tccacgtccg tgagcaccac caggcgctcg gcgcccagag ccacggccag
      541 cgcggacgcg gcgaggtccg cgttcacgtt gtagacctcc cggtccgcac cgcgggcgat
      601 cggtgagacc acgggaatcc ggccctgctc cagcagcgtc cgtacggtcg ccgcgtccac
      661 ggacacgatg tcgccgacca gaccgatgtc aacgggctgt ccgtccaccc aggccgggcg
      721 ccgttcggcc gtcatggtgt gcgcgtcctc accggacagg cccacggcga acggtccgtg
      781 tgcgttgatg gcgccgacca gctcgcgctg cacctgaccc gtcagcacca tccggaccac
      841 gtccatcgtc tccggggtgg tcacccggag gcccgcctcg aagcggacct ccaggtccag
      901 ccggtcgagc atcgcgctga tctgagggcc gccgccgtgc acgacgacgg ggcgcagccc
      961 ggcgtgccac agctccacca cgtcctgggc gaacgtccgg tggagcgagg ggtccaccat
     1021 ggcgttgccg ccgaacttca cgacgaccgt ccgcccctgg agctcctcca gccacggcag
     1081 gtccccgacg gtcggatccg ccccggccac atcctgatcg acgggtgtcc ccatccttgt
     1141 ttccactccg ctcatgagct gtaggtgctg ttctcgtgga cgtactcggc ggtgaggtcg
     1201 tcggtccgga cgaccgccgg gtcctcgccg gcgcggaggc cgacggtgac ggtgatccgg
     1261 cgttgtgaca tgttcggctt gtcgcgggac gggccggcag ctccgtcgcg gcagccccgg
     1321 acgtcgttga tggccacgtc caggtcgagg cacacggcgg gggcggcgtc agcgaactcg
     1381 gcctcgccgg attccttgat gccggcggcg acaccgctcg caaggaaccc ctgggcagcg
     1441 gtcacggtca cggagccact ccattcgtgg gcaggcccag gggctcaggc aggccgagag
     1501 cgacgttcat gcactgcacc gcgccaccgg cggtgccctt caccaggttg tcgatggcgc
     1561 tcacacagac gagacggccg gcgtcctggt ccacggccac ctgtaccagg gcggtgttgg
     1621 agccgacgac cgagccggtg gacggccatc ggccgaccgg tagcagccgg acgaacggtt
     1681 cgtccgcgta cgcctcctcg aacgcggcgc gtacccggtc gggagcgtcc ttgccggaga
     1741 ccgcgggacg cagccgggcc gaacaggtgg cgaggatgcc gcgggacatg ggcgccaggg
     1801 tcggcgtgaa cgacacggtg acccgctcgc ccgccaaccg cgacaggttc tgcgtcagtt
     1861 cgggcgtgtg ccggtggcct ccgccgacgc cgtacgggct catggaaccc atcacctcgg
     1921 aagcgagcga ctgcggcttc accgcgcggc cggccccgga cgtgccgccg gccgcgacga
     1981 tcacggcttc cggctcgacc aggcgggcgg cgtaggcggg catcagggcc agggtgaccg
     2041 ccgtcgggta acagccgggc acggcgatcc ggcgggcacc cggcaactcg gctcgcgcgc
     2101 cgggtagttc cggcagcccg tacagccatg tcccggcgtg cggcgagccg tagaagcgcg
     2161 tccatgcggc ggcgtcgcgc agccgaaagt ccgcgccgca gtccaggacg agcgagtcct
     2221 cctccagacc gcgcgcgagc ggcgccgact cgccgtgggg cagggcgagg aacaccacgt
     2281 cgtgtccgcg cagcacgtcg gccgaggtgg actccagcat ccggtccgcg agcgccggca
     2341 ggtgcggttg cagctcaccg agccggtgcc ccgcgctgct gtgggccgtc acggcgccga
     2401 tctccacctc cggatgggaa gacaggaggc gcaggagttc gccccccgcg tagccactgg
     2461 caccggccac agcgacccgt acggtcatct tcgttccgtc tcttcttgat acttggggat
     2521 gtttcggtgc tcgaagggtt cggcaggggc gtcacgcgtc tttcggcacc ctgtgcagca
     2581 gcaggtcgtg cagcagcgcg tcggtcgtgc ggaccacgcc gctgcgtgcc gcccagcgca
     2641 gtgccgtggc gtgctcctcg gcggagaagt cggccacggc gtccgccacg acgaacggct
     2701 gaatgtcgtt catgaaggcg tccgcggcgg tcagaaggac gccgaggtgc gcgtgcaccc
     2761 cgcagatgat cagttgatcc cggttctcct gacgcagcag cctgccgaga tggctccgga
     2821 ggaaggcgtt gtggcgcacg ttcgccagca cgtgctcgcc cgggcgggga agcagagggc
     2881 cgacgatggc ggctgcgtcg gcctcgtccc cgatgccggg cccccagacg tcggcgacga
     2941 gcccccgctg gccgggctgc tgggcggcgg gctcggcgct gaagaacacc ggtatgccga
     3001 gtgccccggc gagttcgcgc agagcagcga tgttgcggac cagttccacg acgggcggga
     3061 ggccgggagg gaaggcccgt acgaaatggt tctgcatgtc gtgcacaagg agcgcgcacc
     3121 gatccggatc gacggtccat gacgcgcacg atgcggggag tgccgagcgt tcgggcatcg
     3181 gatacgactc gatggtcggc aaggccatga ccgtccctcc ccgggagaat cccacgcgcc
     3241 acaccatggc acttagctaa gcctaaccta accctgtttc ggtcaggtcg cccgccagta
     3301 accgagagcg tgcagccgct ccgtcggtac gccgagttgt ttgcgcgcga aggaggcgag
     3361 ggcccgggtg gtcgccgtgt cgcaggcgat ccagagatag gaggcatcgt ccacgcgttc
     3421 cgggagggcg gcacggaccg tctcgatcag gtgggcgccc ttgtctcggc gtggcacatg
     3481 gacgacctcg cgggacgcgg tgccgacccg cggagcgtgg tcgctgtcgc agacgtgcga
     3541 cgtctcgtac cagaccgtgg ccggcgtgag tggcatcgag ccgagcagtg agtcgatcgc
     3601 cggccgggat gcggcgtcgc cgacgacgag aagccgggaa ggcgggggat ccggcggggc
     3661 gaactccgaa ccctgcaccg tcgcctcgat ggtggcgccg ggatgtgctg cgcgggccca
     3721 gtcgctggcg cggccggagt gcagcgcgaa gtccatgctg aacgtcccct cggcggggtc
     3781 gggatccaca agggtgtagg cgcgctggtg gggtcggccg ccgttgtcga accagagacg
     3841 cacccacatc gtcgggtgaa ccccggtcgc ccgcagcatc ccgccgtcgg agaaggagag
     3901 tcggtggagt ctgtcggaga gtcgttcgtt cgatctgacg gtgagtgtga agtccttgcc
     3961 tcgcatgagc ttgaggaccg caccctgcca gccgtgtccc acggcatccc cttgaagtcg
     4021 cgatgattag gtaagcctaa cccaattcga tctgtggggt gagacgctgc cgttggaagt
     4081 gctcgccgcc gcactggccg aacgtgggat cccggtgcgc acgttcggtg gcgcgctgcc
     4141 cgtcgagtcg ctcgtcgcgg cggtgcacag gaccgggccg gccgcggtgg ggtcgtgggc
     4201 gcagtcccgt accaccgcca gccggccact ggcacagcac gtggccgcga tggagtgggg
     4261 gtgcgcggtg cccgccggaa gccggtcgtc ctgacgctcg gacccggctg ggccgggcag
     4321 gcggtggccg gcctgccgcg tccgtcgggg gccgtcgcgg tcgtggagtc ggtcgcgtcg
     4381 gggtgacggg acgtcgcccg tgccgcactc ggccgctgtg gcgcctggca tcggccggcc
     4441 cgacgtgatc cgctgggcgg atgtccgcac cctcggcctc gacactcggt gagtgccggt
     4501 acctgtgcgc ggatcaccgg gcgaccggat cggtgcacgg cgcgccggtg tcgggtacgc
     4561 acgccggagt cggttcctgg cgcgtgggtg acgtcgggcc gacctcgatc ggccgcatcc
     4621 acgaccggcc ggcgcccgaa gaggcgctga cggaagagac gtgtcgaccc tttggccggg
     4681 agtgaggcgt gaacatctac ggtgcgcgtg ttccggtggc cggtgccacc ggcgtcctcg
     4741 gcggtgagcg caccgccgag gtggccggcc ggggtgcacg cacggccctc gccggacgcg
     4801 attcgcgtcg cctgccccgg gccgcccagg cgccctccag ggctgcgccg agtgccgggc
     4861 tccacgccgt gcgccgcgag gcgcggggcg acggcgtcgg ggtgccggac gtccggcccg
     4921 ggcacctgaa cacctgttcc gccgatcggc ccatggtcgg cacggccctg ccactgcttc
     4981 cgggaggcga cccgcgccag gtggccgcaa ccgtcgccga tgcgccggcg acggacgccg
     5041 atgcgccggc gacggacgcc gaggtcctgc gcaccgcccc caacggaacg cccgtcgtcg
     5101 aacggcgggc ccggtgagcc gaggtcccgc accctccgcc cgtacctccg aggtggtcgt
     5161 cgtcggcggc ggcgcggccg gcctcagcct cgcgcaccgg ctgacggaga caggcgccgc
     5221 caccgtgacc gtcgtcgaac cgccggacgg cccgctgcgc ccgcccgagc ggacctggtg
     5281 ctactgggac cacggcaccg gagacttcga cgaagcggtc accgcctcct ggtcccggct
     5341 gcgcatccac ggcgccgacg gcggcgagtt caccgtcgac cccgccccgc tcctctaccg
     5401 catgctgcgc tccgcaccgt tcgaacggct ggtgcactcc cggctggccc gttcccccgg
     5461 tgggcacgtc ctgcgcgcca cggcggaggc ggtgcgcaac gtgtccggcg gggcggaagt
     5521 cctttgcacg gaacccgacg gccggacgct gacgctgcgt gcccgccacg tgttcgactc
     5581 ccgccccctg cccgccctgc ctccggcccg tacgcagctg ctgcagcact tccgcggctg
     5641 gttcgtacgc acggccgcgg gccggttcga tcccgcggtc gccgatctga tggacttccg
     5701 ggtaccgcag ccgcgccacg gactcgcgtt cggatacgtc cttccgctgg cgccggaccg
     5761 ggcgctcgtc gagtacaccg agttctcccg gacggcgctg accacagcgg cctacgagtc
     5821 ggcactcggc cactacagcc gcgacatcct tgacctcggc gcgttcaccg tggaggcggc
     5881 ggagcagggc gtcatcccca tgaccgacgc gcgcttcccc cggcggctcg gggcagccgt
     5941 cttccgtatc gggaccgcgg gcggtgccac ccgtccggcc accggctaca ccttcgccgc
     6001 ggtgcagcgg cagagcaagg ccatcgccgc tgccctgcgc gacgggcgcg ggaccgtgcc
     6061 accaccccac gggcggcggg cgctcgcaat ggacgcggtg ctgctgcggg ccctggacac
     6121 cgggcggatc gacggccccg cgttcttcac cgacctgttc cgccgtactc ccgcggagcg
     6181 cctgctgcgt ttcctcgacg gtgccacctc accgtgggag gagtggggca tcggactgcg
     6241 cacccccgtc ggcccgatgc tccggaccgc cgtcgaactc cccttcctgc cccgcaggtc
     6301 ccgtaccgcc ccacgaatcg gagagagcac ccgatgacac tgctgcgcga ccacgatctg
     6361 gcacgcgcct tcgaccacgc gtcgcacacc tacgaccgcc tcacggccct caaccccggc
     6421 taccgcaccg acctgctccg ctcggcgcgc cgcctgcggc tgcccggcga gggagccggg
     6481 ctccacgtac tcgatctcgg ctgcggcacg ggcacctcca cccgggccct gctgcgagcc
     6541 gcgccccgcg cccggatcac ggcggtcgac gcctcgtcgg gcatgcttcg gcgcgcactg
     6601 gacaaaccgt ggcccgccgg cgtgcgcttc ctgcacctga ccgccgaggc agtggcgacg
     6661 gccggggagg gccccttcga cgcggtgttc gccgcctacc tcttccgcaa cgtcaccgac
     6721 ccggaccggg tcctcgcggc ggtccggacc cagctgcgac cgggcggacg cctcgccgtc
     6781 cacgagtact gtctcagcgg ctcgcccgtg catcgcgccc tgtggacggc agtgtgccaa
     6841 ggagtcgtca tcccggcggg cacgctcagc ggcgaccgcg gcctgtaccg ccacctgtgg
     6901 cacagcgtcc tcgacttcga caccgcaccc gccttcaccg accgactcac gcgggccggc
     6961 ttcaccggtg tgcgcgccgt gcccgtcgcc gggtggcaga ccggcatcgt gcacaccttc
     7021 ctcgcccgca acgcctgcgc cgacgcagcc gggtgcgccc gatgagcgcc cgcccgagcg
     7081 gtaccgcccg acggggccgc gaccgcaagg ccgaggtact gatgcccgca cccggccgga
     7141 accggttcga gtacggggac gcgccgtccg tcgccgtcgt cggcggtgga atcgccggtc
     7201 tcgccgcggc cactctgctg gccgaacgcg gcgcccgcgt gaccctctac gaacaggagg
     7261 aatcactcgg cggccgtctc gccggccgcc ggacccgcct ggccgacggc tccgtggcga
     7321 ccatgagccg cggcttccac gccttcttcc ggcagtacta caacctgcgc ggcctgctgc
     7381 gacgcaccga ccccgccctc acgcggctca ccccactgcc cgactaccct ctgcggcaca
     7441 gcggcgggct gaccgacagc ttcgcccgcg tcccgcggac cccgccgttc agcgcgctcg
     7501 gattcgtcgc cctgagcccc accttcggct ggcgggacct cgccaccatg gacgcccggg
     7561 cggcactgcc gctcctcgac gtccgcgtgc ccgaggtcta cgaacgcttc gacggcatca
     7621 ccgcgacttc gttcctggag gcggtccgct tccccgaggc cgcccaccac ctcgcgttcg
     7681 aggtgttctc ccgaagtttc ttcgccgatc cgcgtgaact gtccgccgct gaactgctgc
     7741 tgatgttcca catctacttc ctcggctcgg cggagggcct gctcttcgac gtgccgaacg
     7801 accccttccc gcaggcgctc tgggagccgc tcggcgacta cctccagcgc ctcgggacgg
     7861 ccgtgcgcac cggctcaccc gtgcacggcg tccatccgcg cgacgccggg ggagccgagg
     7921 tgcggaccga caccggcgtg gaccgtcacg aagcggtggt gctcgccctc gacaccgagg
     7981 gactgcgccg gctcgtcgcc gcgtcacccg gcctgggcac cgccgcctgg cgcgacgacg
     8041 tcgccgcggt gcgcaccgcc ccgccgttcc tcgtctcccg gctctggctc gatcggccgg
     8101 tgtgcgccac tcgtgcggga ttcctcggca ccagcgggta cggcggcctg gacaacatca
     8161 gcgtcctgga acggtacgag ggcgaggccg cgcgctgggc cgcccggaac cgtggctcgg
     8221 tggtggaact gcacgcctac gccgtcgccg ccgacgcgga atcggagaag gtgcagaaca
     8281 ggctcgtcga gcaactgcag caggtgtacc cggagacgcg tcaggcgcgc atcgtcgacg
     8341 tccggcacga gtggcgctcg gactgcccgc tcttcgccgt cggctcccac caccggcgac
     8401 caaccgtgcg gacgccccac ccatggctga cgcttgccgg tgacgcgatc cgctgcgatc
     8461 ttccggtcgc gctcatggaa cgcgccgcca ccaccggctt cctggcggcg ggggccctgc
     8521 tcgccgcctg gggcatccgg ggccaggtgc tgtggacggt tccccgggcg ggccgttccc
     8581 cggcgctgcg ggcactcggc gcactcgtgg cacgccgtgc gcgcgcctag ccggtgctcc
     8641 ccggcgcccc cggccgccga gcgtcccggc ccggacgacc acgacccggc ctcgtccgcc
     8701 cggcgccgtc agcccgggaa ccgtccggtg ctgcgcagcg cccagcgtcg ttcggcgtag
     8761 gccaggtcgt cgcgccacag gcgcccggcc gtacagcgca tcaacgggcg cagcgcgggg
     8821 gctgctgccc gggccagcgc gaagccgcgc cggtccgagg tggcgacgac cgcctcgacc
     8881 acggcggtcc gtggccgctc gtcggccgca ccggtcagcg gcgtggcatg ggtctccacc
     8941 acggacgtgg ctccctcgcc ctgagtgatg cgcatgacca ccgtgcgcgg ctccggcgcg
     9001 gtgaactcgg cgcggaccgg gaccaccaga cgccccgcca ccaggaagga gacgtcgacg
     9061 acaaaagcgt cgtcatcgtc accctgcggc tcacgcacca ccgtcaggtc gacgaaggac
     9121 tgcggatgga accaggagcc gtgccagggg tccagccggt tggccaccac gtcctgcggt
     9181 tcacaccgcc ccaccgtcgt gaacacggcg tccacccggc tgcctgtcgt gggccgcacc
     9241 ggcacgacgg ggcgctgcga aggctcctcg ccgcccaccg tgtccagccg tacccacacc
     9301 agcaccccgt cgtcgtgcac ggggtacggc gtccagccgg cgaacggaga accgtccagg
     9361 gccagtccgt gccagtggca caccagcctg ccgcacacca cgcggctgtc gcgcagaggg
     9421 gcacccagat gtgggcaggc gcccggaccc gcgcgcagtt cacccgtgtc cgagcgccac
     9481 agcacgacct cgacgccgcc caccgtcctg ccgcacgggc gcccgccggc gcgcacgtcc
     9541 cgggaggcac cgacgacgaa ccagttgccg gagcgacgtg cacacgcccg tttgagcgcg
     9601 tcggagatca gcgccggccg cgcctcccgc caggtcggcg actgcgccgc ccattccggg
     9661 ccacggcgcc gccgcagcgg cgatgtccag cgagtcctgt ccgctcggtc actcactgcc
     9721 cgtgtccctc ccactcgagt gccgtgccgt gccgcttgcc acgggcgccg gacgcggggc
     9781 acgggcgcgc caccgggcgc cgagcacgtg tacggcaccg gccgcggcgg tggccgcacg
     9841 ccggccgcgc gagaccaccg cacggtgatg cagcacggtg tagtcatggc ccgcgatcgc
     9901 gtcgagaatg ccgccgtaca gggtgaacgc ggtgtggata caggggcgca cccgcgggtc
     9961 gagcatggcg atgccgggtt ccgccgcccg gtacacgtcc ctggtcatgg cctccgcggc
    10021 gacgagcgcc gcgcggatcc gcgggtcgcg gcggcccgtg cggcggctcc actccagcag
    10081 cggcctgtcc acaccgtggg cggcgagcag gtccgcgggc aggtagacac ggccgcggtc
    10141 caggtcctcg cccacgtccc gcaggaagtt ggtgagctgg aaggccaccc cgagggccgc
    10201 cgcatgcggc gccgcctcgt cgcggggaac gaccgtaccg agcaccggca gcatctgcag
    10261 gccgatcacc gcggccgagc cgtgcatgta gctctgcagg tcggcgtagg tcggatagtc
    10321 cgtgacggtc aggtcggcgc gcatcgaggc caggaagtcg gcgaacagcg tgggctcgat
    10381 gtcgtaccgg tcggccgtgt ccgccacggc ccggaccacg ggttcgtccc cgcggccggt
    10441 acgcagcccg tgcgcgaggt cgctctccag acagtgcagc agccggtcac gctcctcggg
    10501 tgcccggcgc cggtcgagag cgtccacgat gtcgtccgcc cagcgggcga agccgtacag
    10561 cgcgtgcacg gccgagcggc gttccagggg cagcagacgg gtggccagga agtaggtccg
    10621 gccgtgacgg gcgttgagcc cccggcatcg gctgtatgcg gcgcgcaggg acggatcggt
    10681 gatcccggcg gcgtccagtt cacgacgggt catcggcacc tgccgcggtt ggggtgggcg
    10741 gggcggcggc cggggccggc cgggttcgag cggggtggcg ctccgaggag ccggtgacgc
    10801 gggcggcggc gagtttgccg ctgatgagca ccgtcgggac gccgacgccg ggggtggtcc
    10861 cgcagccggc cagcaccacg ttgtccagtc cgcgtaccag gttgcgcggg cggaagggcc
    10921 cggtctgggc gaacgtgtgg gagaccgaga aggggctgcc cgccgcatgg ccctgtgccg
    10981 tccagtccag cggggtcacc aggagctcct cctcgatgct gcccgcgaac ccgtccaggc
    11041 cccggcgctc caactcgtcg accaggctgt cgcggtagcg cgggcccagg tcccgccagg
    11101 ttgcggcggc ggggccgacg gtggtgttcg gacagggggc caggacgtag tggaggtggc
    11161 ggcccggcgg cgcgagggtg gcatcgtgtg ccgtcgggcg ggtgatcagc agggacgggt
    11221 cgctcatcag cgctcccgag cgggtcagtt cgtcgaacgt gcgctcccat gccgccccga
    11281 aggagagcgt gtgatgggcg aggccgggcc aggtgcggtc cgtcccggcg tgcaggatca
    11341 ctgccgaggg tgcgtgccgc agccggaccg ggcgtcgggg agctcgcccc aggagccggt
    11401 gagcggccga cagttcgcag ctcagcacca ccgcgtcaca agggatccgc tcacctgagg
    11461 ccaggtgtac ggccctcacc cggtccgccg agcgttccag cgtgctcacc tcggccgacc
    11521 atcgcaggtg ggcaccggcg tcggcagccg ccgcggccat ggcgcggggg agcgcgtgca
    11581 tgccgccctt ggggaaccag acgccggcca cggtgtccat gtaggcgatc accgcgtagg
    11641 ccgcgagggc tcgggcgggg gccaccccgg cgtacagggc ctggaaggag aagacacggc
    11701 gcagccgggc gtcggagagg aagcggccga tttggtggtc cagccgcccg aagccgccga
    11761 gcgccgccag acgtgccaga tccgggtgca ggagtgggag gggcgagtcg aagttggtgt
    11821 cgatgaagcg tcgtatctgc gcccggtaca gccgctgaag ccagtcccgc agcctgcggt
    11881 agcccgccgc ctccgtcggt ccggcgaaac gccgcacttc cgcctccatc gcctcgccgc
    11941 cggtgtgtac gtcgagcgag gtcccgtccg cgaaggccgc ccgataggca gggtgcaggg
    12001 ccaccagttc gacatggtgg tcgaggctgt cgccgacggc cgcgaaggcc tcgtcggcca
    12061 ggtgcggcat ggtcagcacc gtgggaccgg tgtccacctg gtatccgccg agccgtacgc
    12121 ggccggcccg gccgcccgga ccggcgtccc gttcgacgac cgtgacccgg cggccggcgc
    12181 ccagcaggtg gagggcacag gccaggccgg acagtccggc acccaccacg acgacgtggt
    12241 cggtcggtcc cgtcaccgtc ctcacatgtc cccctgggtg cggagcgggg tgacgcacga
    12301 tgcccgttcg accagcgcgg cgaactcccg tcggacggcg ggctcggcgc cggtggcctc
    12361 gaagtgcccg aggctcgtgg tcgccaactc cacgatcttc gactccacca cggcccggga
    12421 gccggtccgc tccaacgccc ttcgcatgtg ctcgacggtg tgctccggcc gggggcccgc
    12481 tgacggggcg agtacggctg cggcctcctt gtccccggag gcgtcggcga gttcgagggc
    12541 gacggcgagg aggtaggtga gcttgcgtga ccccaggtcg tcgcctaccg gcttgcccgt
    12601 cgacgccggg tcaccgaagg cgccgaggag gtcgtcgcgg agctggaagg ccaaccccgc
    12661 gcaccggccg gcggcacgca acgcgtccag ggacgggccg gcggcggcca gcgacgcgcc
    12721 cagcgccaag ggccgctcga cggtgtacag ggcgctcttg agggtggcga tggtcagcgc
    12781 ctcgtcgacg ccggacgagc cgcttgcctg cgcgtggagg tcgcggtact gcccggcgac
    12841 catttccccg cgcatcgcct gccactcgcg gtagagccgc gggccgtgcg gcgaaccgag
    12901 tgccgtctcc gtcagcagat cgtccgccca ggccagcgcc aggtcgccgg cgagcacggc
    12961 ggcggaggtc ccgaacgact ccgccgagcc ggtcatccgt gctgcccagt gcatgcgggc
    13021 gaggtcgacg tgcatcgccg gtgctccccg gcgcagcagc gatccgtcca tcacatcgtc
    13081 gtgtatgagg gcgcatgcct ggaggagttc gagggccgct cccgtgtgca cgaccgccgt
    13141 ggcgtcgccc gagccaccca cggcccgcca tccgcaccac gcgaacgcgg aacgcagccg
    13201 cttcccaccg cgccggacga acgctgcgac gcggccggcg acgtccaggg cgaacacggg
    13261 gtccacgccg cgggcccggt ccagacccgc gtcgaggacg tgtcccagga ccgtctcgac
    13321 ggccctgcag gcgtcgaggg ccgtgagcgg ctcgtcgacg agtcccgccg gttccgccac
    13381 ggtcggccgc agtccaagca tgctcggccc ctcttcacca tcggtcacct gtacacctgt
    13441 gcttctgtac cccaccgggg tgcggatgcg ccgatttgcc gccccgtcgg gggcctgtcc
    13501 ggggaaccgc tcactccacc ggcccagcgg cgcaggtctc ctggcgatgg ctcagcccgg
    13561 cggtctccgg gccgacgcga tgccggtcgg cgaagctcca ggagcaccgc gggcaggggg
    13621 cggcgcctgg agagccaggg ggaccgcaac gggggcaggt acgccgacgc ctgcgtacgg
    13681 cgcgtggctc cccagacgcg gccgcgggcg tgccggaagc gtgccgcccc gtcggctagg
    13741 ccgatcaacg gggcgggatg gcggagcccc gcgcgtcggt cctccgggag ccgccagggc
    13801 tcgtgcacgg cccggtcgtc catgtcctga agctcgggca cccagcggcg tacgtaggcg
    13861 ccgctcgggt cgtagcgcct gccctggagc acggggttga ggacgcggtg ggggcgggtg
    13921 tcggtgccgg ttccggcggc ccactgccag ttgagctggt tgttgacgat gtcgccgtcc
    13981 acgagcaggt ccgggaagtg ccgggctccg atccgccagt ccacgtacag ggtcctggtc
    14041 aggaagccgg ccaccagcag gcgcccccgg ttgtgcatcc agccctcgtg gcgcagttgg
    14101 cgcatcgcag catcgacgac cggatagccc gtacggccct ctcgccaggc ggcgatgtcc
    14161 tcggccgcct cgtcctcggt ccgccaccgg tcgtgccggg tgcggtagtc ccggacggac
    14221 gattcgggcc tggccgccag gacctgatgg tggaagtcgc gccagcacag ccggcggacg
    14281 gacgcctcca ccccgggtcc cccctgcgcg cgggcctgcc gggcgagttc caccggcgag
    14341 agggcgccga aatgcagata gggcgacacc cgtgaggtcg cgtcagccgc caggtcgtcg
    14401 tgctgctcgt cgtacctgga caaccccgac cggacccacc gcgagaaccg ttcacggccc
    14461 gccgtctcgc ctcctgaggg aaggcccggc gagactccgg acggctcgcc gggagaggga
    14521 gcggctcgcc gcgcaccgtg tcggggacgc gcacaatgcg cgcgccggac aggtctcccg
    14581 cagccgctcg cgcgaccagc ggcggaagta gggggtgaac acggcgtagt ggtcgctgcc
    14641 ggcgggcgtc acggtgcccg gcgcgacggc ggtgatcacc gcgtcgtgca cgcgcagcgc
    14701 cacgccgcgt tcgccgaggg cctggcgcag cagctcctcc cgccggtgtg cgtaccgggt
    14761 gacgcccgcg gccatgtgca ccgccgcggc gccgcactcg gcgacgaccg cgccgacctc
    14821 acggacgacc ggccccgagc gcaccacgag ccggccaccg cgccggcgca gggagccgtc
    14881 gagatcggtc agcagtccgc gaggaaggca cgccggttgg gtgcgtcgaa gcccgccgcc
    14941 cggacaccgg ggtcgcggac gaacagcggt accacctcgt cgcccgccgc gagggcggcg
    15001 cgcagcggcg gatgatcgtg cagacgcagg tccgaggtga acaggacgac cgcgacggtc
    15061 atggcatgac tcccggtggg gtgctgcggt gctgttgcgc taatgacgga ctcttcgcgc
    15121 gcggcggggc cgccgggcgc ggccggcctg cgccggggtc ccacgcgctc tcatgccctt
    15181 ggcggcggcc tgggtgatgt tgcgggccat gccgccgaag acgacggcgt ggaacgggga
    15241 gacggaccac cagtaggcgt ggcccagcag gccccggggg tggaacaggg cgcgctgccg
    15301 ataacgggtg cggccctcct cgtccgtctc ggagcacatc tcgagccatg ccagacccgg
    15361 cagccgcatc tccgcacgca aacgcagcag ccgtccgggc tcgatctcct cgacccgcca
    15421 gaagtccagc gagtcaccga cccgcaggtg ctcggcgtca cgtcgtccgc ggcgcaggcc
    15481 gacaccgccg acgaaccggt ccagccggcc ccggaccgcc caggccaggg ggaacgagta
    15541 ccagccggtg tcgccgccga ttccctcgat cactcgccac agggactccc tggacgcgtc
    15601 gaccgacaac tgcctcttgt cctggtagag gctgccgccg gcccagtccg ggtcggtggg
    15661 cagcggatcg ctgggcgccc ctggtgcggc ggcggacgac cagcgggtgg cgacctgcgc
    15721 ctcccgtacc ctgcgcagcg ccagggtcag cgcctcgtcg aacggcagcg gcctgcccgg
    15781 ggtgtcgggt acgtaccggg cgatgtcgtg ctcgtggcag acgacctcgt gacgcagcga
    15841 ctccgtcagg ggccgggcca ggttggcggg caccggggtg accaggccga cccagtgact
    15901 ggacagtccc ggggtgagaa ccggtaccgg cacgatgacc cgccgccgca gtccggcgac
    15961 gacggcgtac cggcgcatca tgtcccggta ggtcaggacg tccgggccgc cgatgtcgaa
    16021 cgcccggtcg acatcggccg gcatggtggc cgagccgacg agatagcgca gcacgtcccg
    16081 taccccgatg ggctgcgtgc gggtgtgcac ccacctgggc gtgaccatga ccggcaggcg
    16141 ctcggtcaga tagcgcagca tctcgaacga cgccgacccc gagccgatga ccaccgcggc
    16201 gcgcagcacg gtggccggca ccggcccgtc caggaagatc cgcccgacct cggtgcggga
    16261 ccgcaggtgc ggggacagct gcgcttccgg gacgccccgg ggcgtgagcc cgccgaggta
    16321 gacgatccgc cgtacccctg cggcatgcgc ctgttcggtg aagagccggg ccgcttgccg
    16381 gtcggtctcc tcgaacccgg agccgcttgc gagggcgtgc acgaggtagt acgcgacgtc
    16441 gatcccgcgc atggccgcgc agaccgaatc ggcgtccgtg acgtccccct gaaccgtctc
    16501 gacgtctgcg gcccagggat ggtcgcggag tttgccgggg gagcgggcca ggcaccgtac
    16561 ccggtggccc acccccagca gttccggtac cagacgcccg ccgatgtatc cggacgctcc
    16621 ggtgaccaga cagtgcagcc gctccgtgtg ccgctgtccg tccgtgccca cgtgtctcct
    16681 cctggctcgc gccgacgatg gtgccccgtg gcaccgatca tgtccgcaac ggccggggac
    16741 gtcgcggcgc tgcggccggt cgccgcatcc gccagggccc acgggacggc ccgggcgcac
    16801 gggacggcgc ggcgtcccgg cccgcccgcc gtacgggccc cgtccatcgc cacgccgtgc
    16861 acgtgctctc ctgtcgcaga ggccgggcgc cgaccgccca cacaaccttt cgtacgagaa
    16921 ggcacggacg gatgcacgaa ggtgtccgtg accgcccgcc cactcgcgcg cagggcggga
    16981 gccggcggtg gtccgcccgg ccgccggcgc cgtgtccgtc cgcccaccgc aggaacggaa
    17041 gacggccccg gcgcgtcggc cccctcccgc cgggtggtca cggtccgctc gcggatccgg
    17101 tgccgccgtt gcgggccagg gcgctgggcc accacgcgcg gggaccgatg tcgatcacca
    17161 gcgcgggcac caggagtgag cggaccacga gagtgtcgag caggacgccg aaggccacga
    17221 tgaacgcgat ctggaccagg aaggcgagcg ggatcaccat cagggcggag aacgtcgcgg
    17281 cgagtacgac accggccgag gtgatcactc ctccggtcgt cgacaacccg cgcagtaccc
    17341 cctgccgggt gccgtgcgcg agcgcttcct cccgtacccg ggacatcagg aagatgttgt
    17401 agtcgacccc gagcgccacc aggaacacga acccgtacag cggcacggag gcgtcggtgc
    17461 cgctgaatcc gagcagctgc tcgaagacga gcgccgagac cccgagcgtc gccaggaagt
    17521 tgaccgcgac ggtcgccacc agcagcaccg gaacgagcag tgagcgcagc agcagcacca
    17581 ggatcagcag gatgatggcg aggaccaggg gcacgatgac ggttcggtcg gcggcggcgg
    17641 tccgctgggt gtcgaactgt tgcgcgctgt acccgccgac cagcgcctcg gcaccggaaa
    17701 ccgcgtgtac gtcctcgcgc agccgctgga tcgtctcctt ggcggcgtcg ctgtcggccg
    17761 cggcctccag cgtggcgtcg atacggacgc ggccgtcgac gacgagcggc tcgtcggcag
    17821 tcggacggcc cgaagcggac accggccctg ccgacgccac gccgtcggtg ctcctcgccg
    17881 cggccgtcac ctgagcggca cggtcggcgt ccgcgatgat gacggcgggg ttgccggagc
    17941 caccggggaa gtgttcgccg agcgtctcct gggcggcgac cgaggaggcg tcgttcacga
    18001 agatctcgtc cagcggtacg cccttggcgg acagtgacgg ggagaaggcc gcgaagacag
    18061 tcagggcgag cgcggtcacc acccatgtcc ggcgtggtcg ggcgtccacc gtcgcggcga
    18121 cacggcgcca cacgccgtgc ccctcgccgg acgcgtccga tgccttcggc cgggacggcc
    18181 agtaggcgct gcggcccagc agtgcgagaa cggccggaag gaaggtgagc gtggacagca
    18241 cggcgcacac gatgccgatg gcgccgaccg gcccgagggc gcggttgttg gtgaggtcac
    18301 tggcgagcaa cgccagcagg ccgagtgcca cggtggccgc gctggcggtg atggcaccga
    18361 acgagcggcg caccgccgcc accgcggccg cggcccggtc gccgcgcacg gcgaactcct
    18421 cgcggaagcg tgcggacagc agcagcgcgt aatcggtggc ggcgccgatc acgaggatgg
    18481 agaggatgcc ctgcacctgg ccgtccaccc gtacgaggtc ccggtccgcc agcgcgtaga
    18541 cgacggcgca cgcgaggccc agggcgaaga cggagcccag gatgatcagg aacggcagca
    18601 ggacgctccg ttggaccagc agcaggatca gcagcaccgc tgccagtgcc acgcccagca
    18661 agagcccgtc cacgcccgcg aacgcgtcgg aaagctcgct ccggctcgcc gccgggccgg
    18721 cgatctgcgg cgtggcgtcc ggcacgccct gcgccgtccg gcgaacctcg gcgaggacgt
    18781 ccggcagggc ctctcccagg tcgggttcga gctggacgac ggcctgcatc gcctccttgt
    18841 cgtgggaaag gagggcgggc gaagggcggc cgacgacccc gggccgtccg gcgagttcgt
    18901 cgaccgcgcg ggtggccgcg gcctgctgcc gttcggagac ctggccgccg tccgccgtcc
    18961 agaccacgac ggcgggcagg gtttcggact ggtcgaacgc ctcacgcgcc gtgagcacct
    19021 tcgtggactc ggcgctctgc ggcaggaacg cggcctggtc gttggtggcc acctcgccca
    19081 gcttgctggc gtagggcccg agcgtgcctc ccacccccag ccagacgagc agcaggacga
    19141 gcggtacgag ccatcgcgcc cacggcggcg tcgttctcat gagcatcccc aagctgtcga
    19201 aacaagtcag ccatcaagta tctcgatgat tgagagaatc tatactggac acatggacgg
    19261 caaagacgac cgcgcgtcat ctcctcccga ggacgactcg acggggttgc aatcgttcgt
    19321 ggtcctgttg cgcgggatga acggcgagtt caaccgcatc gctcacgagt tcgcccacgc
    19381 acaggggctg catctcaccg atgtgcaggc cctgatcgcg atcctggaca ccgaccccgc
    19441 cgaggggccc atgacgcccg gtcaactgcg caaacagctc aatctcacct ccggcgcggt
    19501 gaccgcgtgc atcgaccggc tggagaaggc gggtcacgtc cgccgtgtcc gggctgtcga
    19561 cgaccgccgc gtggtgcacc tgcactacgc ggagacggcc agaagcgtcg ccggggagta
    19621 cttccggccc ctggcccgct gcgccgggat cgcacgcgaa cgcttcaccg acgaggaact
    19681 ggccgtagtc gtccgctttc tgaccgagat gaaccgggag ctcgtcgtcc tgcgccgcca
    19741 ggccgctccc ggcgcgtagg tgccgggtgg gccgcttccc ggtggtcggc tgaaccgtaa
    19801 ccgttcgccg ttcgtgcgga gaaatgccga taggaggcac ggtccctttc gggcgaacgg
    19861 cacccaccga ttcccatcac gccgagaagt ccggtcgggc accgccgtgc gctcaaatgc
    19921 tcattgatgg ccgaaatctg tacatttgtc gccagggcgt gaagttgtcg ggcgggccgg
    19981 catccgcacc ccggatcgcg aaccgcgcgg gcgaggacaa tatgttcaac ttgagtgcgc
    20041 cgatcgtcac cacgttcgtc gtgtacgcgc tcgccatgat cggaacaggt gtctgggcct
    20101 acacccgtac tcgcagtttc gccgacttcg ccctgggcgg gcgccggctc agtccgttgg
    20161 tcgccgccct gtccgcaggg gcgagcgaca tgtccggctg gctgttcctg gcgcttcccg
    20221 gggccgtcta cgcggcaggc atcggttacg cctggatcgc ggtcggcctg gcgatcggca
    20281 cctatctgaa ctggctgttc gtcgcgccga ggctgcgcac ctataccgag cgcgccgaga
    20341 acgccgtaag cctctccgcc tacctggagg agcggttcga ggaccgtacc cggatgctca
    20401 ggatggtctc ggcagcggtc accctggtgt tcttcaccgt ctacgtgggc agtggtctgg
    20461 tggcgggcgg gctgctgttc gaaaccgtct tcggcatccg ctacgggctc ggggtcactc
    20521 tgaccgcatt ggtgatcgtc atctactcgt gcctgggcgg cttcctggcg gtgagcctga
    20581 cgcacgtgct gcagggcctg ctcatgttct ccgccctgat cgtggtgccc gtggccgcca
    20641 tcacggctct cgggggcttc ggctctctgg gcgacgccct caacagcagg gagccgggcc
    20701 tgcacgacct ggacgcccag gtcgactatc aggccggcca gtggtcggcc gacgggtcgc
    20761 tcagtgccgt tgcgatcatc tcgttgctcg cctggggcct cggatacttc ggccaaccgc
    20821 acatcctggc ccgtttcatg ggcatccgga gcacccgcga cgtccccgcg gcccgtcgta
    20881 tcggaacggc gtgggtcgtc gtcgtgctcg tcggcgccac gctcgtgggc ctcgcgggaa
    20941 tcggggaggt cgaccccccg ctgtccgccc ccgagacggt gtacatctcc ctgtgccaga
    21001 cgctgctcaa cccctgggtc gcgggggtga tgctgatcgc cgtgctggcc gccatcatct
    21061 cgaccgcgga cagccagttg ctggtgtcgt cggtcgctct gacggaggat ttctaccacg
    21121 cgttcctcaa ccggcgcgcc tcggacaagt cgctggtgcg gatcgggcgc ggtgccgtcg
    21181 tcgtggtgat cgtggtggcc ttcgtgatcg cgctcaaggg cgacggggta ctgggcatcg
    21241 tcgcgcacgc ctgggcgggc ttcggcgccg ccttcgggcc ggtcgtgctg ctgtcgctgt
    21301 actggccgcg gatgacctgg gcgggggcca tggcgggcat cgtgtcgggt gcgctcacgg
    21361 tgctgctgtg ggaggacatc aacccgctgc tcgggccgtt cgagtcgggc atctacgaga
    21421 tggttcccgg tgtcctggtg gccacggccg gcgccctcct cttcggtcgg tacgtcggcc
    21481 ggccgccgaa gcgggccttc tggcggatgc cgggaggagg ggtgagtcag ctggtgctca
    21541 ccccgttcct cacccacgca ccggtcggca tggcggtcct ggacacggat ctgcgctacg
    21601 tctgggtgaa cgaacccctg gaccgcctga tccccctcga acagcggctg gggaagcagg
    21661 tgggcgacgt gctgccagga gcggaggccg aactcctgga gaaacagatg cgcacggtcc
    21721 tgcggaccgg ggatccggtg atggactccg agttccgcgt cgagagcgat cccgaccgtg
    21781 gccgcgcgga ctcggtctcc ttcttcggaa tgaaagaccg ccacggccgt accgtgggca
    21841 tcctctacat ggtcatcgac gtcaccgaac gctggcgtgc ccagaaacgc ctcgccctgc
    21901 tgaacgacgc cggtgcccgg atcggcagca cactggacat cacccggacc gcacaggaac
    21961 tggccgagga ggccgtgccg tccatcgccg aattcgtcgc cgtcgacctg ctggactccg
    22021 tcatgagagg cgaggaaccg gcccctggac ccgtcggcat ggcacccgtg atccgtcgcg
    22081 cgggacaggc gtcggtgcgc gagggctgcc cggagggcag cctcgccgtg ggggaggcgg
    22141 tccggcgggc cccctcctca cccgtgaccc gttccctgct ggagagcagg accttgctgg
    22201 aacggacgct ggaccgcgcc gccagcccat gggtgaccga ggacccgtcg ctcggcacat
    22261 ccatcctgaa gtacgacttc cgctcgctga tggtggttcc ggtacgggcg cgcggcgtca
    22321 ccctgggcgt ggccaccttc gcccggtccc ggcgccgtcc cttcgaggac gacgacgtgc
    22381 gtctcgccga ggagatcgtc tcgcgcgcgg cggtgtgcgt cgacaacgca cgccggttca
    22441 cgcgggagcg caccgcggcc cgttccatgc agcgttccct gctgccgcag gcactgacgg
    22501 ggggatccgc tctggaggtg gcctcgtggt accacccggc cgacgccccg agcggcgtgg
    22561 gcggcgactg gttcgacgtg atcccgctgt ccggcgcccg ggtcgccctg gtcgtcggcg
    22621 acgtggtcgg acacggtatg aacgcggcgg ccaccatggg acgcctgcgc acggcggtac
    22681 gcacgctcgc caacctggac tatgccccgg acgaactgct cgcccacctc gacgacctgg
    22741 tcatcggtct catggggccg tacgacgaca aggagccggc ggcgcacgag gacgaggccg
    22801 tgggcgcggc gttcctgggg gccacgtgcc tgtacgccgt gtacgacccg gtcagcatgc
    22861 ggtgcaccct ggctcgggcg gggcacctcc cgcctttgct catccgcccc ggcggcggcg
    22921 tcgagatcct ggacctgccc gcgggtccgc cgctcggcct cggctacctt cccttcgagt
    22981 ccgtcgaact ggagctggcc gagggcagtc tcatggcgtt ctacaccgac ggcctcgtcg
    23041 agaccttcga ccgcgacatc gacgtgggga tttcccagct gggcgctgcc ctcgccgtgc
    23101 cgagagcgac gctggaggag atcgggcggg gaggggtcga cgcgctgctg accggccccc
    23161 cgccggacga cgccgccctg ctcctcgccc ggacccggtc cctcgcgccg caccaggtcg
    23221 cttcctggcc cctgcccagc gacccggccg ccgtcgcgca cgcccgaagc ctcgccgtcg
    23281 gccaactggc ggagtggaat ctcgacaatc tggcgttcac cacggagctc atcgtcagcg
    23341 aactggtcac caacgccatc cgccacgcgg ccggaccggt ccacctgcgc ctgatccgcg
    23401 a
//
