LOCUS       NZ_BMWB01000023        25812 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence23, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000023
VERSION     NZ_BMWB01000023.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 127781)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25812
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25812
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..25812
                     /SMILES="CC(=O)CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25812
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[<1870:5812](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <1871..5812
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            <1..1827
                     /locus_tag="IE198_RS27090"
     CDS             <1..1827
                     /NRPS_PKS="Domain: PKS_AT (34-328). E-value: 8.5e-110.
                     Score: 358.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS27090_PKS_AT.1"
                     /NRPS_PKS="Domain: ACP (446-517). E-value: 2.6e-28. Score:
                     90.1. Matches aSDomain: nrpspksdomains_IE198_RS27090_ACP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (532-607). E-value:
                     6.2e-13. Score: 41.4. Matches aSDomain:
                     nrpspksdomains_IE198_RS27090_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012901.5"
                     /locus_tag="IE198_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyltransferase domain-containing protein"
                     /protein_id="WP_189891149.1"
                     /sec_met_domain="PKS_AT (E-value: 1.8e-109, bitscore:
                     358.7, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-13, bitscore:
                     43.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SLLSGLDALVAGERPEHVVTGAAQGRPAKGKTAYLFTGQGSQRPG
                     MGRELHAAFPVFAEALEEVAGHLDAHLGTPLLSVMFAPDGDPRARLLDGTDYAQPAIFA
                     YEVALFRLLESWGVRPDVLAGHSLGELSAVCVAGVLSVPQAAELVAARGRLMEALPARG
                     AMVAVQATEAEIRGTLVGREGAVDIAAVNGPASVVLSGDEDAVEAISAQWAARGRKTSR
                     LNVSRAFHSPHMDVMTDAFERVAAKLTYSAPRIPVVSDVTGDLLGAREARSPAYWVAHI
                     RRTVRFHDQIQRLQRYGAEAFLEVGPDTVLSTAGRGCLADEPGGSTPVLMSTSHAERPE
                     VPALITALSSLHTHGATVDWRKWFGTGPSATGLPTYAFQKQHYWPQDTTVRPAAATGPG
                     LVQPEEATEPEDVTESDVTRDTPVQQASSRMAGWRALPPGERHDAVLRTVRAEAADVMG
                     HDTLDAVEPERGFLDHGFDSVMAVKLRNRLAELTGRKLPSTLLFDHPTPAAVTAFLLTE
                     PAETDAGPAPAPSLSDQLDRLEADLARLPADDHRRARITERLKGLLTVHAPAGSAAGGA
                     HGDREGRPDRDELATATDDEMFALIEKELRRG"
     aSDomain        106..987
                     /ASF="Neither malonyl-CoA or methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27090_PKS_AT.1"
                     /evalue="8.50E-110"
                     /label="IE198_RS27090_PKS_AT.1"
                     /locus_tag="IE198_RS27090"
                     /protein_end="328"
                     /protein_start="34"
                     /score="358.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQRPGMGRELHAAFPVFAEALEEVAGHLDAHLGTPLLSV
                     MFAPDGDPRARLLDGTDYAQPAIFAYEVALFRLLESWGVRPDVLAGHSLGELSAVCVAG
                     VLSVPQAAELVAARGRLMEALPARGAMVAVQATEAEIRGTLVGREGAVDIAAVNGPASV
                     VLSGDEDAVEAISAQWAARGRKTSRLNVSRAFHSPHMDVMTDAFERVAAKLTYSAPRIP
                     VVSDVTGDLLGAREARSPAYWVAHIRRTVRFHDQIQRLQRYGAEAFLEVGPDTVLSTAG
                     RGCLADEPGGSTP"
     aSModule        106..1554
                     /complete
                     /domains="nrpspksdomains_IE198_RS27090_PKS_AT.1"
                     /domains="nrpspksdomains_IE198_RS27090_ACP.1"
                     /locus_tags="IE198_RS27090"
                     /monomer_pairings="mal -> mal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       109..156
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27090_0001"
                     /evalue="2.40E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="IE198_RS27090"
                     /protein_end="51"
                     /protein_start="35"
                     /score="19.9"
                     /tool="antismash"
                     /translation="FTGQGSQRPGMGRELH"
     CDS_motif       280..342
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27090_0002"
                     /evalue="3.40E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE198_RS27090"
                     /protein_end="113"
                     /protein_start="92"
                     /score="10.8"
                     /tool="antismash"
                     /translation="DGTDYAQPAIFAYEVALFRLL"
     CDS_motif       352..474
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27090_0003"
                     /evalue="8.80E-22"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE198_RS27090"
                     /protein_end="157"
                     /protein_start="116"
                     /score="69.4"
                     /tool="antismash"
                     /translation="GVRPDVLAGHSLGELSAVCVAGVLSVPQAAELVAARGRLME"
     CDS_motif       568..606
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27090_0004"
                     /evalue="2.60E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS27090"
                     /protein_end="201"
                     /protein_start="188"
                     /score="14.2"
                     /tool="antismash"
                     /translation="AAVNGPASVVLSG"
     CDS_motif       829..864
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27090_0005"
                     /evalue="1.80E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE198_RS27090"
                     /protein_end="287"
                     /protein_start="275"
                     /score="14.9"
                     /tool="antismash"
                     /translation="YWVAHIRRTVRF"
     aSDomain        1342..1554
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27090_ACP.1"
                     /evalue="2.60E-28"
                     /label="IE198_RS27090_ACP.1"
                     /locus_tag="IE198_RS27090"
                     /protein_end="517"
                     /protein_start="446"
                     /score="90.1"
                     /tool="antismash"
                     /translation="RTVRAEAADVMGHDTLDAVEPERGFLDHGFDSVMAVKLRNRLAEL
                     TGRKLPSTLLFDHPTPAAVTAFLLTE"
     aSDomain        1600..1824
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27090_PKS_Docking_Cterm.
                     1"
                     /evalue="6.20E-13"
                     /label="IE198_RS27090_PKS_Docking_Cterm.1"
                     /locus_tag="IE198_RS27090"
                     /protein_end="607"
                     /protein_start="532"
                     /score="41.4"
                     /tool="antismash"
                     /translation="DQLDRLEADLARLPADDHRRARITERLKGLLTVHAPAGSAAGGAH
                     GDREGRPDRDELATATDDEMFALIEKELRR"
     gene            <1871..5812
                     /locus_tag="IE198_RS27095"
                     /old_locus_tag="GCM10010381_55040"
                     /pseudo=""
     CDS             <1871..5812
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (2-20). E-value:
                     0.00019. Score: 12.9. Matches aSDomain:
                     nrpspksdomains_IE198_RS27095_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (24-448). E-value:
                     6.7e-181. Score: 593.7. Matches aSDomain:
                     nrpspksdomains_IE198_RS27095_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (556-854). E-value: 7.6e-108.
                     Score: 352.3. Matches aSDomain:
                     nrpspksdomains_IE198_RS27095_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_PP (938-1023). E-value: 1.7e-25.
                     Score: 81.1. Matches aSDomain:
                     nrpspksdomains_IE198_RS27095_PKS_PP.1"
                     /NRPS_PKS="Domain: Thioesterase (1096-1305). E-value:
                     1.4e-25. Score: 83.0. Matches aSDomain:
                     nrpspksdomains_IE198_RS27095_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579424.1"
                     /locus_tag="IE198_RS27095"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55040"
                     /product="type I polyketide synthase"
                     /pseudo=""
                     /sec_met_domain="mod_KS (E-value: 7.1e-223, bitscore:
                     733.0, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.1e-92, bitscore:
                     303.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.6e-107, bitscore:
                     352.3, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.4e-13, bitscore:
                     42.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.4e-14, bitscore:
                     47.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="RLVTAELKRTRRQLEETEDAAREPVAIVGMACRFPGDVTSPDALW
                     ELVAEGRDAITGFPADRGWDVDAVHDPEPGTPGKTYTRHGGFLSDAAEFDPAFFGISPR
                     EALAMDPQQRKILEVSWEAFEYAGLDATAMRGAEVGVFVGSNSNDYLLNVLDAREVAEG
                     FIGTGNSASILSGRVAYTFGFEGPAVSVDTACSSSLVAVHLAAQSLRQGECSLALAGGA
                     TVMATPTAFIEFSRQRGLAPDGRCKSFSATADGTTWSEGAAVLLLARLSDARRLGYPVH
                     AVIRGSAVNQDGASAGLTAPNGPSQRRVIRQALANARLTADRVDAVEAHGTGTPLGDPI
                     EAQALLATYGRARAEGRPLWLGSLKSNLGHTQSAAGAGGVIKMVMAMRHGVLPRTLHLT
                     EPTPRVDWDAGDVRLLTEEQKWPDTGEPRRAAVSSFGVSGTNAHVILEGTPAVEAARPD
                     EDASAHGPLPWVLSGRTEEALRAQAGRLAAHLAARPDLRPADVAASLAMTRAAFEHRAA
                     VVGREREELLSGLEALASDRRAPGLVTSRTAPSGGRTAFLFTGQGSQRPGTGRELAAHS
                     TAFADALDEVCTEFDQHLEHPLRDVLFAEDGTHEAGLLDTTAYTQPALFAVETALMRLL
                     EDWGLRPDMVAGHSIGELSAAYAAGVWSLADACALVAARGRLIQGLPAGGAMVAVQATE
                     DEVRAQLVAGCDGVDIAAVNGPAAVVLSGDEGAVAELARHWAERGRDTKRLRVGHAFHS
                     PHVDAITEEFAEVARGLSYRAPSLPVISMLTATPVSDELCRPEYWVRHVRGTVRFHDAV
                     HTLHERGATVFLEIGPGGVLTAAGRKCLPDLAPESFVPVLRHRTPEPAAVMTAVAQAHT
                     VGVSPAWERVLPAARRRVELPTYAFRRRRYWLEGMAGAGSERTVCPRPAANPAEREPAP
                     GTPPLAHRLAEAPEEERGELLLTLVREQAATVMGGVDPAEVEPGRPFLELGFDSLMGVE
                     LGSALAADCALALPPSLIFDHATPAALAAFLGKEITAGSGLRPSAAPSAYSLEALYRAA
                     NDLDRPEDALELTKVASRLRPAFHSVAEAGQDPVTVELTQGTDQAGIICCPAPVPLYGA
                     QQYARLAAAFRGTRGVSALLAPGFTAGELLPAGFEVMQEFLAEGVRGQTGGAPFVLLGH
                     SSGGWFAHSLAAHLARTGQSPEAVVLLDTYLLDDPALHRMQRELAQGVLDREDDFGAMT
                     DVRLTAMGKYFGFFTDWVAEEPSVPTLLLRASEPLGRVADGEEWHPDWKFDSTVLDTEG
                     DHFSMMDDYAPQTAAAVNDWLAGLVGGKG"
     aSDomain        1880..1933
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27095_PKS_Docking_Nterm.
                     1"
                     /evalue="1.90E-04"
                     /label="IE198_RS27095_PKS_Docking_Nterm.1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="20"
                     /protein_start="2"
                     /score="12.9"
                     /tool="antismash"
                     /translation="VTAELKRTRRQLEETEDA"
     aSDomain        1946..3217
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27095_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="6.70E-181"
                     /label="IE198_RS27095_PKS_KS.1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="448"
                     /protein_start="24"
                     /score="593.7"
                     /tool="antismash"
                     /translation="VAIVGMACRFPGDVTSPDALWELVAEGRDAITGFPADRGWDVDAV
                     HDPEPGTPGKTYTRHGGFLSDAAEFDPAFFGISPREALAMDPQQRKILEVSWEAFEYAG
                     LDATAMRGAEVGVFVGSNSNDYLLNVLDAREVAEGFIGTGNSASILSGRVAYTFGFEGP
                     AVSVDTACSSSLVAVHLAAQSLRQGECSLALAGGATVMATPTAFIEFSRQRGLAPDGRC
                     KSFSATADGTTWSEGAAVLLLARLSDARRLGYPVHAVIRGSAVNQDGASAGLTAPNGPS
                     QRRVIRQALANARLTADRVDAVEAHGTGTPLGDPIEAQALLATYGRARAEGRPLWLGSL
                     KSNLGHTQSAAGAGGVIKMVMAMRHGVLPRTLHLTEPTPRVDWDAGDVRLLTEEQKWPD
                     TGEPRRAAVSSFGVSGTNAHVILEG"
     aSModule        1946..5788
                     /complete
                     /domains="nrpspksdomains_IE198_RS27095_PKS_KS.1"
                     /domains="nrpspksdomains_IE198_RS27095_PKS_AT.1"
                     /domains="nrpspksdomains_IE198_RS27095_PKS_PP.1"
                     /domains="nrpspksdomains_IE198_RS27095_Thioesterase.1"
                     /final_module
                     /locus_tags="IE198_RS27095"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       2429..2476
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0001"
                     /evalue="1.50E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE198_RS27095"
                     /protein_end="201"
                     /protein_start="185"
                     /score="20.1"
                     /tool="antismash"
                     /translation="GPAVSVDTACSSSLVA"
     CDS_motif       2852..2896
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0002"
                     /evalue="3.50E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="IE198_RS27095"
                     /protein_end="341"
                     /protein_start="326"
                     /score="12.8"
                     /tool="antismash"
                     /translation="VEAHGTGTPLGDPIE"
     CDS_motif       2957..3001
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0003"
                     /evalue="4.80E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE198_RS27095"
                     /protein_end="376"
                     /protein_start="361"
                     /score="9.8"
                     /tool="antismash"
                     /translation="GSLKSNLGHTQSAAG"
     CDS_motif       3266..3292
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0004"
                     /evalue="3.20E+01"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS27095"
                     /protein_end="473"
                     /protein_start="464"
                     /score="-1.3"
                     /tool="antismash"
                     /translation="GPLPWVLSG"
     aSDomain        3542..4435
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27095_PKS_AT.1"
                     /evalue="7.60E-108"
                     /label="IE198_RS27095_PKS_AT.1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="854"
                     /protein_start="556"
                     /score="352.3"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQRPGTGRELAAHSTAFADALDEVCTEFDQHLEHPLRDV
                     LFAEDGTHEAGLLDTTAYTQPALFAVETALMRLLEDWGLRPDMVAGHSIGELSAAYAAG
                     VWSLADACALVAARGRLIQGLPAGGAMVAVQATEDEVRAQLVAGCDGVDIAAVNGPAAV
                     VLSGDEGAVAELARHWAERGRDTKRLRVGHAFHSPHVDAITEEFAEVARGLSYRAPSLP
                     VISMLTATPVSDELCRPEYWVRHVRGTVRFHDAVHTLHERGATVFLEIGPGGVLTAAGR
                     KCLPDLAPESFVPVLRH"
     CDS_motif       3545..3589
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0005"
                     /evalue="4.40E-04"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="572"
                     /protein_start="557"
                     /score="13.2"
                     /tool="antismash"
                     /translation="FTGQGSQRPGTGREL"
     CDS_motif       3725..3775
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0006"
                     /evalue="3.00E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="IE198_RS27095"
                     /protein_end="634"
                     /protein_start="617"
                     /score="11.0"
                     /tool="antismash"
                     /translation="AYTQPALFAVETALMRL"
     CDS_motif       3788..3910
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0007"
                     /evalue="3.00E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="IE198_RS27095"
                     /protein_end="679"
                     /protein_start="638"
                     /score="67.7"
                     /tool="antismash"
                     /translation="GLRPDMVAGHSIGELSAAYAAGVWSLADACALVAARGRLIQ"
     CDS_motif       4004..4042
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0008"
                     /evalue="1.60E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="IE198_RS27095"
                     /protein_end="723"
                     /protein_start="710"
                     /score="11.8"
                     /tool="antismash"
                     /translation="AAVNGPAAVVLSG"
     CDS_motif       4262..4297
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0009"
                     /evalue="1.10E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="IE198_RS27095"
                     /protein_end="808"
                     /protein_start="796"
                     /score="15.5"
                     /tool="antismash"
                     /translation="YWVRHVRGTVRF"
     aSDomain        4688..4942
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27095_PKS_PP.1"
                     /evalue="1.70E-25"
                     /label="IE198_RS27095_PKS_PP.1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="1023"
                     /protein_start="938"
                     /score="81.1"
                     /tool="antismash"
                     /translation="LAEAPEEERGELLLTLVREQAATVMGGVDPAEVEPGRPFLELGFD
                     SLMGVELGSALAADCALALPPSLIFDHATPAALAAFLGKE"
     aSDomain        5162..5788
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27095_Thioesterase.1"
                     /evalue="1.40E-25"
                     /label="IE198_RS27095_Thioesterase.1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="1305"
                     /protein_start="1096"
                     /score="83.0"
                     /tool="antismash"
                     /translation="CCPAPVPLYGAQQYARLAAAFRGTRGVSALLAPGFTAGELLPAGF
                     EVMQEFLAEGVRGQTGGAPFVLLGHSSGGWFAHSLAAHLARTGQSPEAVVLLDTYLLDD
                     PALHRMQRELAQGVLDREDDFGAMTDVRLTAMGKYFGFFTDWVAEEPSVPTLLLRASEP
                     LGRVADGEEWHPDWKFDSTVLDTEGDHFSMMDDYAPQTAAAVNDWL"
     CDS_motif       5351..5413
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27095_0010"
                     /evalue="1.40E-05"
                     /label="NRPS-te1"
                     /locus_tag="IE198_RS27095"
                     /protein_end="1180"
                     /protein_start="1159"
                     /score="17.6"
                     /tool="antismash"
                     /translation="PFVLLGHSSGGWFAHSLAAHL"
     gene            5819..6619
                     /locus_tag="IE198_RS27100"
                     /old_locus_tag="GCM10010381_55050"
     CDS             5819..6619
                     /NRPS_PKS="Domain: Thioesterase (30-250). E-value: 5.8e-52.
                     Score: 169.3. Matches aSDomain:
                     nrpspksdomains_IE198_RS27100_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356025.1"
                     /locus_tag="IE198_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55050"
                     /product="thioesterase II family protein"
                     /protein_id="WP_189891153.1"
                     /sec_met_domain="Thioesterase (E-value: 1.2e-53, bitscore:
                     175.6, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3e-16, bitscore:
                     53.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATHSAGTARTDAPDRQWIRRFHPAPDAPVRLLCLPHAGGSASAY
                     FGLSQLLAPKVEVLAVQYPGRQDRRDELLLDSIAALRAGLAEELTSWLDRPIALFGHSM
                     GAVLAYETARLLAEDERAHLAHLFVSGRGDPARKADVALDLLDDRAMVQALGDLGGTDR
                     RLLEDEDVLRMVAPAIRSDYRAVRTYRHAPGPLLPCPVTALVGDQDAMAPVDDVEKWAS
                     YTSAEFSLKVFQGGHFYLLEQFRKVSDHVYDGLGDSLSVQASPG"
     aSDomain        5909..6568
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27100_Thioesterase.1"
                     /evalue="5.80E-52"
                     /label="IE198_RS27100_Thioesterase.1"
                     /locus_tag="IE198_RS27100"
                     /protein_end="250"
                     /protein_start="30"
                     /score="169.3"
                     /tool="antismash"
                     /translation="RLLCLPHAGGSASAYFGLSQLLAPKVEVLAVQYPGRQDRRDELLL
                     DSIAALRAGLAEELTSWLDRPIALFGHSMGAVLAYETARLLAEDERAHLAHLFVSGRGD
                     PARKADVALDLLDDRAMVQALGDLGGTDRRLLEDEDVLRMVAPAIRSDYRAVRTYRHAP
                     GPLLPCPVTALVGDQDAMAPVDDVEKWASYTSAEFSLKVFQGGHFYLLEQFRKVSDH"
     CDS_motif       6101..6166
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27100_0001"
                     /evalue="6.90E-09"
                     /label="NRPS-te1"
                     /locus_tag="IE198_RS27100"
                     /protein_end="116"
                     /protein_start="94"
                     /score="28.1"
                     /tool="antismash"
                     /translation="RPIALFGHSMGAVLAYETARLL"
     misc_feature    6649..6663
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.66"
                     /tool="antismash"
     misc_feature    6728..6742
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            6786..8030
                     /gene="ccrA"
                     /locus_tag="IE198_RS27105"
                     /old_locus_tag="GCM10010381_55060"
     CDS             6786..8030
                     /EC_number="1.3.1.85"
                     /GO_function="GO:0043880 - crotonyl-CoA reductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (43-249). E-value: 5e-16. Score:
                     50.6. Matches aSDomain:
                     nrpspksdomains_IE198_RS27105_PKS_ER.1"
                     /codon_start=1
                     /gene="ccrA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960016.1"
                     /locus_tag="IE198_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55060"
                     /product="crotonyl-CoA carboxylase/reductase"
                     /protein_id="WP_189891156.1"
                     /sec_met_domain="ADH_N (E-value: 2e-10, bitscore: 33.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.1e-24, bitscore:
                     78.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNSLYELGDIPPIGTVPKQMYASVIRRERYGPPHQAFRNEVVDV
                     PEAGPGQVLVLVMAAGINYNNVWASLGRPVDVISSRLQQGEREDFHIGGSEGSGVVWAV
                     GEGVSQVSVGDAVILSGCRWTESSADIRLGADPMTSASQSVWGYESNFGSFAQFALVDD
                     YQCHPKPPGLTWEEAACFLLTGATAYRQLCGWPPHDVRPGDPVLIWGGAGGLGSMAIQI
                     TRARGGIPVAVVSDEERARYCRELGAQGTVNRLHFDHWGRLPDIGDRAAMGRWTESVRA
                     FGRSFWEALGERRSPRLVLEHSGQDTIPTSMYLCDNAGMVVICGGTTGYNADVDLRFLW
                     MRQKRLQGSHFANLRQCRDIIHMVSTGQLDPCLSWTGGFDDIGKAHQLMHDNQHPQGNQ
                     AVLVNAPRTGMTELP"
     aSDomain        6915..7532
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS27105_PKS_ER.1"
                     /evalue="5.00E-16"
                     /label="IE198_RS27105_PKS_ER.1"
                     /locus_tag="IE198_RS27105"
                     /protein_end="249"
                     /protein_start="43"
                     /score="50.6"
                     /tool="antismash"
                     /translation="DVPEAGPGQVLVLVMAAGINYNNVWASLGRPVDVISSRLQQGERE
                     DFHIGGSEGSGVVWAVGEGVSQVSVGDAVILSGCRWTESSADIRLGADPMTSASQSVWG
                     YESNFGSFAQFALVDDYQCHPKPPGLTWEEAACFLLTGATAYRQLCGWPPHDVRPGDPV
                     LIWGGAGGLGSMAIQITRARGGIPVAVVSDEERARYCRELGAQ"
     CDS_motif       7392..7451
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS27105_0001"
                     /evalue="8.20E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE198_RS27105"
                     /protein_end="222"
                     /protein_start="202"
                     /score="15.3"
                     /tool="antismash"
                     /translation="GDPVLIWGGAGGLGSMAIQI"
     gene            8117..8653
                     /locus_tag="IE198_RS27110"
                     /old_locus_tag="GCM10010381_55070"
     CDS             8117..8653
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.5"
                     /locus_tag="IE198_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55070"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_189891158.1"
                     /transl_table=11
                     /translation="MDQNQLDILWSEREIRAVLQRYCRGLDRLDEELVKSAYHEDAYDD
                     RGVIRGNAHDFVKQIVPILRDTYTGTLHTLHGSTIEVDGDSAGVETYCTAYHYRESDGI
                     KRVEQFAGRYIDRFELRDGVWKIARRVVLNDFSLAQEVPLDPAEAQAGFNPSRRDATDV
                     SYQVLPLSGPDAPTV"
     gene            8749..9972
                     /locus_tag="IE198_RS27115"
                     /old_locus_tag="GCM10010381_55080"
     CDS             8749..9972
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058200.1"
                     /locus_tag="IE198_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55080"
                     /product="cytochrome P450"
                     /protein_id="WP_229834387.1"
                     /sec_met_domain="p450 (E-value: 1.8e-25, bitscore: 82.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETDQRPPTLPRQRTCPFSPPPELEELRGTDPISRMTFADDSEG
                     WLLTRHADVRAALASRSVSSHPGRTPQPWRNLAPEMRAEEYLPGFLIFMDPPNHSRYRR
                     LLTKWFTMRAIRKLEPRIEQIVSDALDAMEAEGGPVDLVQSFALPIPLLVICELMGIRY
                     DDRVEFMDMVLRLQDLEATPEELGALGAKMNQFMIDLCAAKRKNPGDDLLSHLIQDPDA
                     EPALTDLEVAGIGVLMLIAGHETSANMLGIGTYTLLQNPGQWDLLRNDIGLIDQAVEEL
                     LRHQTIVQQGLPRGVTEDMEIAGHAIKPGETLLASLPAANRDPEVFPDPDRLDITREHN
                     PHLAFGHGIHLCLGMELARVEMRCAWRGLVKRFPDLRMAARIEDIPWRDDQIVYGVYKL
                     PVTWGDAP"
     gene            9969..11237
                     /locus_tag="IE198_RS27120"
                     /old_locus_tag="GCM10010381_55090"
     CDS             9969..11237
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146332.1"
                     /locus_tag="IE198_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55090"
                     /product="cytochrome P450"
                     /protein_id="WP_229834389.1"
                     /sec_met_domain="p450 (E-value: 5.6e-33, bitscore: 107.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGQVTNSVTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDP
                     YWEPLRREQPLQRVTLPYGGEAWLATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPP
                     ADAVLSVEGPDHARLRRLVGKVFTPRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDF
                     SLPFAVSMICELLGVPPEDRKRFCTWSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQR
                     RTRPTEDLIGSLVTARDAEDKLTEGELVRLAEAILIAGYETSASQIPNFLYVLFRNPHL
                     LERLRNDHDLIPDAVEELLRYVPIGTVDGFPRTATEDVELGGVLIRAGETVVPSMGAAN
                     RDPELFADPEELDLTRSPNPHLGFGAGPHHCLGAQLARVELQITLTTLFRRYPRLRLAV
                     PEESLSWKAGLMVRGMHTMPITW"
     gene            11297..12406
                     /locus_tag="IE198_RS27125"
                     /old_locus_tag="GCM10010381_55100"
     CDS             11297..12406
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="IE198_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55100"
                     /product="serine hydrolase"
                     /protein_id="WP_189891162.1"
                     /transl_table=11
                     /translation="MNDAIDEREHGPEDVGMDPAALKRLTEVVRSRGGAAQLCVMRRGT
                     VVLDRSFGCSPDSLFLLYAATKPFPALAVHKLAERGQLELDSPVANYWPKFARHGKGEV
                     TVRHVMQHRAGVPVGRGMVRTMRTARDWERSVRDLEESRPRWPGGKVAAYHFMSYGFIL
                     GEVVQRVTGQPFRDFVTSELFAPLGLNDLHLGLPDSAWGRHVPARAAHPSEWPNQWMSN
                     SRRYRQAVVPSAGLSGTAAQLARFYQMLLAGGALEGVRVLQAESVAEARKPSNEGGNDA
                     SLKRPVHWSHGFMLGGPGPDPRDLARVMGDASDARTFGHAGTTSSVVWADPARELVFAY
                     LSNIQPEFGAGVERLREVSDLALDACEAG"
     misc_feature    12667..12680
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.0"
                     /tool="antismash"
     gene            12746..13594
                     /locus_tag="IE198_RS27130"
                     /old_locus_tag="GCM10010381_55110"
     CDS             12746..13594
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="IE198_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55110"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_268246505.1"
                     /transl_table=11
                     /translation="MPNWIEHSESKFPPRVGILGPLEVRFAENSGSGVSVNGIRVRALL
                     AALTAQLGEAMSTERILKEVWADNPPATDRKAVAVAVLRLRRVLDDRDGQWLLTRPSGY
                     VLAIPPDHLDAARAERLVREGKAALTAGDPRVASQSLRHALAQWRGEPYADAHATAAVV
                     RRTSELESLKCEAVQARIDADLELGHHQELVGELRSLTAANPLHEPHWLQLMLALYRSG
                     RQAESLSAYMDVRQALAEKLGVDPGRPLQELHLRILRADAGLLYGSASSVSSQLLLAGR
                     S"
     misc_feature    12751..12769
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.31"
                     /tool="antismash"
     misc_feature    12809..12811
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12875..12877
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13770..14102
                     /locus_tag="IE198_RS36715"
     CDS             13770..14102
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036823.5"
                     /locus_tag="IE198_RS36715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_373299994.1"
                     /transl_table=11
                     /translation="MPYPEEAVLVSNAVDARRREFTTVRHCARRAMCEPGLPGAPYSRK
                     ARCSLTAAPDRGKPYALCRAPGAPGRWPLSEGVILTAVAVPAPSCSPGEFGTRSEDSPG
                     GNRNAR"
     gene            14065..14598
                     /locus_tag="IE198_RS27140"
                     /old_locus_tag="GCM10010381_55120"
     CDS             14065..14598
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483533.1"
                     /locus_tag="IE198_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55120"
                     /product="flavin reductase family protein"
                     /protein_id="WP_229834390.1"
                     /transl_table=11
                     /translation="MKTVLEGIEMPAEELTDSFRNAMSSFPSGVTIVTTVDSEGEWWGF
                     TATSFCSVSLDPPLVLVCLSVEAQCHPAFSTATSWVVHILPPRHRELALWFSSKGVDKF
                     SRGDFTTNAQGHPVLEGTCAVLECEASARYGGGDHSILVGEVTRSHVHDDEPAVYFRRK
                     FHTLTPLLETTTSA"
     gene            complement(14682..15467)
                     /gene="pgl"
                     /locus_tag="IE198_RS27145"
                     /old_locus_tag="GCM10010381_55130"
     CDS             complement(14682..15467)
                     /EC_number="3.1.1.31"
                     /GO_function="GO:0017057 - 6-phosphogluconolactonase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pgl"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104611.1"
                     /locus_tag="IE198_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55130"
                     /product="6-phosphogluconolactonase"
                     /protein_id="WP_189891166.1"
                     /transl_table=11
                     /translation="MTAAPQLVVHRDKELMAQAAAARLITKIVDAQAARGSASVVLTGG
                     RNGNGLLAALSSSPARDAIDWSRLDLWWGDERFLPEGDPERNATQARETLLDAVPLDPS
                     RVHAMPASDGAYGSDVDSAAAAYATELAAAAGPEDHGPVPTFDVLMLGVGPDTHVASLF
                     PELPAVRETERTVVGVHGAPKPPPTRISLTLPAIRAAREVWLLAAGEDKAKAAEIALSG
                     AGEIQAPAAGAYGRARTLWLLDAAAASKLPRSLYPPASA"
     gene            complement(15464..16489)
                     /gene="opcA"
                     /locus_tag="IE198_RS27150"
                     /old_locus_tag="GCM10010381_55140"
     CDS             complement(15464..16489)
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /GO_process="GO:0065003 - protein-containing complex
                     assembly [Evidence IEA]"
                     /codon_start=1
                     /gene="opcA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527482.1"
                     /locus_tag="IE198_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55140"
                     /product="glucose-6-phosphate dehydrogenase assembly
                     protein OpcA"
                     /protein_id="WP_189891168.1"
                     /transl_table=11
                     /translation="MKIDLTDTTASKINKALVQGRRAIGTPAVGMVLTLVIVTDEENAY
                     DALKAANEASREHPSRTLVVIKRVSRSPRDRAKARLDAEVRVGADAGTGETVVLRLYGE
                     VVDHAQSVVLPLLLPDAPVVVWWPVNAPTDPASDPLGALAQRRVTDTYAAEQPVRELAA
                     RAEAYAPGDTDLSWTRITPWRSMLAAALDQVDCEVTSVEVEGEEFNPSCELLGMWLADR
                     LDVPVKRTSSAGPGLTSVRMESDCGPIVLDRPDGSLATLSIEGQPDRAVALKRRETAEL
                     IAEELRRLDPDDTYSSALRYGVERLGAGPAAAPQPAPAEKAAPAAPAAKKAAPAKKAAA
                     K"
     gene            complement(16486..18009)
                     /gene="zwf"
                     /locus_tag="IE198_RS27155"
                     /old_locus_tag="GCM10010381_55150"
     CDS             complement(16486..18009)
                     /EC_number="1.1.1.49"
                     /GO_function="GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="zwf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004932762.1"
                     /locus_tag="IE198_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55150"
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="WP_373300002.1"
                     /transl_table=11
                     /translation="MGGANPLRDAADRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDL
                     ANRGLLPPGFSLIGFARREWADEDFAQEVHDAVKEHARTPFREEVWQQLIQGMRFVPGT
                     FDDDDAFEQLKSTIEDLDKVQGTGGNFAFYLSVPPKFFPKVVQQLKKHGLADQKEGSWR
                     RAVIEKPFGHDLVSAKELNQVVHEVFPPNEVFRIDHYLGKETVQNILALRFANTLFEPI
                     WNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPASFDADA
                     LAAEKTKVLGAVKLPKDLAKDTVRAQYAAGWQGGEKAVGYLQEDGIDPKSKTDTYAAIK
                     LEIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSPFDSTATEELGQNALVIRVQP
                     DEGVTMRFGSKVPGTSMEVRDVSMDFAYGESFTESSPEAYERLLLDVLLGDSNLFPRVE
                     EVELSWKILDPIEQFWDANGKPAQYPAGTWGPAEADEMLARDGRSWRRP"
     gene            complement(18024..19142)
                     /gene="tal"
                     /locus_tag="IE198_RS27160"
                     /old_locus_tag="GCM10010381_55160"
     CDS             complement(18024..19142)
                     /EC_number="2.2.1.2"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004801 - transaldolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tal"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091869.1"
                     /locus_tag="IE198_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55160"
                     /product="transaldolase"
                     /protein_id="WP_189891172.1"
                     /transl_table=11
                     /translation="MTDALKRLSDEGVAIWLDDLSRTRITSGNLAELMDQQHVVGVTTN
                     PSIFQKAISEGHGYDQQLEDLAARKVTVEEAIRMITTADVRDAADVLRPVFDSTGGQDG
                     RVSIEVDPRLAHNTKATVAEAKQLAWLVDRPNTFIKIPATKAGLPAITEVIGLGISVNV
                     TLIFSLERYREVMDAYLAGLEKAKAAGLDLSKIRSVASFFVSRVDTEIDKRLDALGTPE
                     AKEARGKAAVANARLAYEAYEEVFSSDRWAVLDKAQANKQRPLWASTGVKDKAYKDTLY
                     VDDLVAPGTVNTMPEATLEAVGDHGRITGDTVRGTYEQARAELEAVAKLGISYDDVVQL
                     LEDEGVEKFEASWNDLLKSTEAELKRLAPSEG"
     gene            complement(19177..21264)
                     /gene="tkt"
                     /locus_tag="IE198_RS27165"
                     /old_locus_tag="GCM10010381_55170"
     CDS             complement(19177..21264)
                     /EC_number="2.2.1.1"
                     /GO_function="GO:0004802 - transketolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tkt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318993.1"
                     /locus_tag="IE198_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55170"
                     /product="transketolase"
                     /protein_id="WP_189891174.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-07, bitscore:
                     24.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTKPTTTDLEWTALDQRAVDTVRVLAMDSVQKVGNGHPGTAMSL
                     APAAYVLFQKLMRHDPADADWTGRDRFVLSAGHSSLTLYIQLYLAGYGLELDDLKAFRT
                     WGSKTPGHPEYGHTTGVETTTGPLGQGVANAVGMAMAARYERGLFDPDAAPGTSPFDHT
                     VWCIAGDGCLQEGISAEASSLAGHQKLGNLVLLWDDNHISIEGDTETAVSEDTLQRYEA
                     YGWHVQRVQQLENGDLDPVGLHNALKAAQAETERPSFIAARSIIAWPAPHAQNTEAAHG
                     SALGEEEVAATKRVMGFDPEQHFEVADEVLNHTRGALDRGREARGEWEKVFAAWRTANP
                     ERAAEFDRIRSGELPEGWEDALPEFEPGKSVATRAASGKVLQALGPVVPELWGGSADLA
                     GSNNTTIDKTSSFLPAGNPLPEADPYGRTVHFGIREHAMAAVMNGIALHGNTRIYGGTF
                     LVFSDYMRNAVRLSSLMHLPVTYVWTHDSIGLGEDGPTHQPVEHLASLRAIPGLNIVRP
                     ADANETAIAWREILKRYTKEFGKGAPHGLALTRQGVPTYECNEDAAKGGYVLLEEEGGD
                     AQVVLIGTGSEVQLAVAAREQLQAAGVPTRVVSMPSVEWFEEQDQGYRDSVLPPSLKAR
                     VAVEAGIGLTWHRYVGDAGRIVSLEHFGASADGKVLFREFGFTAEAVAAAARESIDAAA
                     R"
     gene            21573..22526
                     /locus_tag="IE198_RS27170"
                     /old_locus_tag="GCM10010381_55180"
     CDS             21573..22526
                     /EC_number="2.5.1.141"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008495 - protoheme IX farnesyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0048034 - heme O biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381228.1"
                     /locus_tag="IE198_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55180"
                     /product="heme o synthase"
                     /protein_id="WP_373299996.1"
                     /sec_met_domain="ubiA (E-value: 1.7e-22, bitscore: 73.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCVTAVESRPAGVVLATGPGGHRPFGARVKAFVALTKPRIIELLL
                     ITTVPVMFLAEQGVPDLWLVLATCLGGYLSAGGANALNMYIDRDIDALMDRTSQRPLVT
                     GMVSPREGLVFGLTLAVASTLWFGLLVNWLSAALSLGALLFYVVVYTMILKRRTAQNIV
                     WGGIAGCMPVLIGWSSVTNSMSWAAVVLFLVIFFWTPPHYWPLSMKVRDDYARVGVPML
                     PVVAGNKVVARQIVLYSWVMVAVSLLLTPLGYTGWFYTAVALAAGGWWLWEAHALQTRA
                     NAGERGGKLKEMRLFHWSITYVSLLFVAVAVDPFLR"
     gene            22608..22964
                     /locus_tag="IE198_RS27175"
                     /old_locus_tag="GCM10010381_55190"
     CDS             22608..22964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948809.1"
                     /locus_tag="IE198_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55190"
                     /product="hypothetical protein"
                     /protein_id="WP_189891178.1"
                     /transl_table=11
                     /translation="MAETKVDETASAPAPDARAERKAAKLAKQIQAFSKAHGGAEGQLA
                     YIGQRGTRIVLVGEDGGWGDLVAPSHAIAVSAADKSGITLHESFDGDFAAKVRTGPYEW
                     TRMAGIQVGGPSNG"
     misc_feature    complement(22612..22627)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.8"
                     /tool="antismash"
     gene            23030..24115
                     /locus_tag="IE198_RS27180"
                     /old_locus_tag="GCM10010381_55200"
     CDS             23030..24115
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007498294.1"
                     /locus_tag="IE198_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55200"
                     /product="amidohydrolase"
                     /protein_id="WP_189891180.1"
                     /transl_table=11
                     /translation="MIDAASSVRLVDQYCHGVLRTELGIGTFETYLGPVAGAPPAAGTT
                     FFDTQTGFAVRRWCPPLLGLEPHCPPAHYLARRRELGAVEAGRRLLRGTGIATYLVDTG
                     PPGDLAGPAEIAAAAEAQAREIVRLELLAEQVADTSGTVESFLTNLAEAVHGAAGSAVA
                     FTTVAAGRQADRPEPPGTGEVRGAAGRWLAERRVGEPLTDPVLLRHLLWVAVATGLPLQ
                     LHLGEGDPLPLADFAAATAGLGTDLILLYGYPHHRGAAHLASAYQHVYADLGPALARTG
                     TRAAAVLAETLELAPFGKLLFSSGARGLPELHVVAACTFREAVDRVLGGWVADGAWSRA
                     DAERVAGLLGWGNAGRVYGLP"
     gene            complement(24316..25305)
                     /locus_tag="IE198_RS27185"
                     /old_locus_tag="GCM10010381_55210"
     CDS             complement(24316..25305)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318997.1"
                     /locus_tag="IE198_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_55210"
                     /product="heme A synthase"
                     /protein_id="WP_189891182.1"
                     /transl_table=11
                     /translation="MHKPPLTIGAVQTPLAHIAQRWTPSPKILRRAALSAVLMTVLIIV
                     TGGAVRLTGSGLGCDTWPKCTDDSLFATPEQGIHGAIEFGNRMLTYVLSAAVGWAIIAV
                     RATKPRRRGLGRLAWAQFWIVMGNAVIGGVTVWAGLNPWTVAGHFLLANALLTVATATW
                     VRTGEGDGAPRPRVPRPVRKLSWAIVAVSAVLITLGTTVTGSGKHAGDSSDVPRMPWDW
                     SAAAHVHAIAAWVVCALAVAMWLVLRVVDAPDDIRARARDLLLVVLLQGALGYVQYFTG
                     VPELLVAAHMLGSSVMWIAVLRLALSLRERESTPAPAPASPDPALTSA"
     misc_feature    25299..25314
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
ORIGIN
        1 agtcttctca gcggcctcga cgcgctcgtg gcgggggagc ggccggagca cgtcgtcacc
       61 ggcgcggcgc agggccggcc ggcaaaaggc aagacggcgt acctgttcac gggacagggg
      121 agccagcggc cgggcatggg gcgcgaactg cacgccgctt tccccgtctt cgccgaggcg
      181 ctggaggagg tcgccgggca cctcgacgcc cacctgggga cgccgctgct gtcggtgatg
      241 ttcgcgccgg acggcgaccc gcgggcacgg ctgctcgacg gcacggacta cgcgcagccc
      301 gcgatcttcg cgtacgaggt ggcgctgttc cgcctgctcg agagctgggg cgtacgtccc
      361 gacgtgctgg cggggcattc gctcggcgaa ctgtcggcgg tctgcgtggc cggtgtgctg
      421 tccgtgccgc aggcggccga actcgtcgcc gctcgcgggc ggctcatgga ggccctgccc
      481 gcccgcgggg cgatggtcgc cgtgcaggca acggaggccg agatccgcgg aaccctcgtg
      541 ggccgggagg gggcggtgga catcgccgcg gtcaacggtc cggcgtcggt ggtcctgtcc
      601 ggtgacgagg acgccgtcga ggcgatcagc gcgcagtggg cggcgcgggg ccgcaagacc
      661 agccggctca acgtcagccg tgccttccac tcgccgcaca tggacgtcat gacggacgca
      721 ttcgagcgtg tggcggcgaa gttgacctac agcgctccgc gcatccccgt cgtctccgac
      781 gtcaccggcg acctcctcgg cgcgcgggag gctcgcagcc ccgcctactg ggtggcccac
      841 attcgccgca cggtgcgctt ccacgaccag atacagcggc tccagcggta cggtgccgaa
      901 gccttcctcg aggtcggccc cgacaccgtg ctcagcacgg cgggacgggg atgcctggca
      961 gacgagcccg gcgggagcac acccgtcctg atgtccacct cgcacgcgga gcggcccgaa
     1021 gtcccggctc tgatcaccgc gttgagctct ctccacaccc atggcgcgac cgtggactgg
     1081 cggaagtggt tcggcaccgg cccgagtgcc accggcctgc cgacgtacgc cttccagaag
     1141 cagcactact ggccgcagga caccactgtc cgcccggctg ccgccacggg ccccggcctc
     1201 gtacagccgg aagaggcaac cgagccggag gacgtgacgg agagcgacgt gacccgggac
     1261 accccggtgc agcaggcctc ctcccgcatg gccggctggc gggccctgcc ccctggcgag
     1321 cgccacgacg cggtactgcg gacggtgcgt gccgaggccg ccgacgtcat gggtcacgac
     1381 accctggacg ccgtcgagcc ggagcgcggc ttcctcgacc acggcttcga ctccgtgatg
     1441 gcggtgaagc tccgcaaccg cctggcggag ctcaccggcc ggaagctgcc gtcgacgctg
     1501 ctgttcgacc accccacgcc cgccgccgtc accgccttcc tgctgacgga gccggcagaa
     1561 accgatgccg gtccggcgcc ggccccttcc ctgtcggacc aactcgaccg gctggaggcc
     1621 gacctggcac ggctgcccgc cgacgaccac cggcgcgccc ggatcaccga gcggctgaag
     1681 ggcctgctca ccgtccatgc gccggccggg agcgccgccg gcggggccca cggggaccga
     1741 gagggccggc cggacaggga cgagctggcg acggcgaccg acgacgagat gttcgcgctg
     1801 atcgagaagg aactccgccg tggctgagaa cgtggacgag aacaacgagg ccaagctccg
     1861 cgagtacctg cgactggtca ccgccgagct gaagcgtacg cgcaggcagt tggaagagac
     1921 cgaggacgcc gcccgcgaac cggttgcgat cgtgggcatg gcttgccgct tccccggcga
     1981 cgtgacctcg ccggacgcgc tgtgggagct ggtggccgag gggcgcgacg ccatcaccgg
     2041 gttccccgcc gaccgcggtt gggacgtgga cgccgtccac gacccggaac ctggtacgcc
     2101 gggcaagacg tacacgcggc acggcggatt cctctcggac gccgccgagt tcgaccccgc
     2161 gttcttcggg atctcgccgc gcgaggcgct cgccatggac ccgcagcagc gcaagatcct
     2221 ggaggtctcc tgggaggcgt tcgagtacgc gggtctcgat gcgaccgcca tgcgtggcgc
     2281 ggaggtcggc gtcttcgtcg gctccaacag caacgactac ctgctgaacg tgctcgacgc
     2341 acgggaggtt gccgaaggct tcatcggcac cggcaactcc gcgagcattc tctccggtcg
     2401 cgtcgcctac accttcggct tcgagggccc tgccgtgtcg gtcgacacgg cgtgctcctc
     2461 gtcactggtc gctgtgcacc tggcagcgca gtccctccga cagggggagt gctccctggc
     2521 gctggcgggc ggtgcgacgg tgatggccac gccgaccgcg ttcatcgagt tcagccggca
     2581 gcgtggcctg gcccccgacg gccgctgcaa gtccttctcc gccaccgccg acggcaccac
     2641 atggtccgag ggcgcggccg tgctgctcct cgcccggctc tccgatgccc ggcgcctcgg
     2701 ctacccggta cacgccgtca tccgcggcag cgccgtcaac caggacggcg cgagcgcggg
     2761 cctcaccgca cccaacggtc cctcgcagcg gcgggtcatc cggcaggcgc tggcgaatgc
     2821 gcgtctgacg gcggaccgtg tggacgccgt cgaagcgcac ggcaccggca ccccgctcgg
     2881 cgacccgatc gaggcgcagg cgctgctcgc cacgtacggc agggcccgcg cggagggcag
     2941 gccgctgtgg ctcggctcgc tcaagtcgaa cctcgggcac acccagtccg cagcgggcgc
     3001 gggcggcgtc atcaagatgg tgatggccat gcggcacggc gtcctgcccc gcactctgca
     3061 cctgaccgag cccactccgc gcgtcgactg ggacgccggc gacgtacggc tgctcaccga
     3121 ggaacagaaa tggcccgaca ccggggagcc gcgccgagcc gccgtctcct cgttcggtgt
     3181 gagcggcacc aacgcccacg tgatcctgga gggcacgccg gccgtggagg ccgcacggcc
     3241 cgatgaggac gcctccgcgc acggcccgct cccgtgggtc ctctccggcc gcacggaaga
     3301 ggccctacgc gcccaggccg gccgcctggc cgcccatctg gccgcacgac cggacctgag
     3361 gccggccgac gtggcggcat ccctggccat gacacgggcc gccttcgagc accgggcggc
     3421 cgtcgtcggc cgggagcgcg aggagttgct gtccggactc gaggccctgg cctccgaccg
     3481 ccgtgcgccg gggctggtca ccagtcgtac cgcgccgtcc ggcggcagga cggcgttcct
     3541 gttcaccggg cagggcagcc agcggcccgg gacgggccgc gaactggccg cgcacagcac
     3601 cgctttcgca gacgccctcg acgaggtgtg cacggaattc gatcagcacc tcgaacatcc
     3661 tctgcgggac gtgctgttcg ccgaggacgg cacgcatgag gccggcctgc tcgacaccac
     3721 ggcctacacc cagcccgctt tgttcgccgt cgagaccgcg ctgatgcggc tcctggagga
     3781 ctggggtctg cgacccgaca tggtcgctgg gcactccatc ggcgagctca gcgccgcgta
     3841 cgccgccggc gtctggtccc tggccgacgc gtgcgccctg gtggcggccc gcggtcggct
     3901 gatccagggg cttccggcgg gcggcgccat ggtcgccgta caggccaccg aggacgaagt
     3961 gcgcgcccag ctcgtcgccg gctgcgacgg cgtggacatt gccgctgtca acggacccgc
     4021 cgcggtggtg ctgtcggggg acgaaggagc cgttgccgag ctggcccgcc attgggccga
     4081 acggggccgc gacaccaagc ggctgcgggt cggccacgcc ttccactcgc cccatgtgga
     4141 cgccatcacc gaggagttcg ccgaggtcgc gcgcgggctg tcctaccggg caccctcgct
     4201 tcccgtgatc tccatgctca ccgcgacacc cgtcagcgac gaactgtgcc gcccggaata
     4261 ctgggtacgc cacgtgcgcg gaaccgtccg cttccacgac gccgtgcaca cgctgcacga
     4321 gcgcggggcc accgtgttcc tggaaatcgg cccgggtggt gtcctcacgg cggccgggcg
     4381 caagtgcctg cccgacctcg ctcccgagtc gttcgttccc gtgctgcgcc accgtacgcc
     4441 cgagcccgcc gccgtgatga cggccgtcgc ccaggcccac acggtcggcg tgtcgccggc
     4501 gtgggagcgc gtgcttcccg cggcccgcag gcgtgtggag ctgcccacgt acgccttccg
     4561 ccgccgccgc tactggctcg agggcatggc gggagcggga tccgagcgga cggtgtgccc
     4621 ccggcctgcg gcgaaccccg ccgagcggga accagcgccc gggacgccgc ccctggcgca
     4681 ccgtctcgcc gaggccccgg aggaagagcg cggcgaactg ctgctcacgc tcgtgcgcga
     4741 gcaggcggct accgtgatgg gcggcgtcga cccggccgag gtcgagcccg gacgcccctt
     4801 cctggagctc ggattcgact ccctgatggg cgtcgagctg ggttccgcgc tcgccgccga
     4861 ctgcgcgctc gccctgccgc cctcgttgat cttcgatcac gccacgcccg ccgcgcttgc
     4921 cgcgttcctc ggcaaggaga tcaccgccgg gtccggtctc cgcccgtcag cggcgccgtc
     4981 ggcgtactcc ctggaagcgc tgtaccgcgc cgcgaacgac ctcgaccggc ccgaggacgc
     5041 cctcgaactg accaaggtgg cctctcggtt gcgccccgcc ttccacagcg tcgccgaggc
     5101 cgggcaggac ccggtcacgg tcgagctgac gcagggcacc gatcaggcgg gcatcatctg
     5161 ctgccccgcg cctgtgccgc tgtacggggc acagcagtac gcccgtctcg ccgccgcctt
     5221 ccggggcacg cgcggcgtct cggcactgct tgcccccggc ttcacggcgg gtgagctgct
     5281 cccggccggc ttcgaggtga tgcaggagtt cctcgccgag ggggtccgcg gacagaccgg
     5341 cggcgcgccg ttcgtcctcc tcgggcactc ctccggcggc tggttcgcgc acagcctggc
     5401 ggcccacctc gcccgtaccg ggcagagccc ggaagccgtg gtgctcctcg acacgtatct
     5461 gctggacgac ccggcgctgc accgcatgca gcgcgaactc gcgcagggcg tcctcgatcg
     5521 ggaggacgac ttcggggcga tgacggacgt gcggctgacc gccatgggca agtacttcgg
     5581 gttcttcacc gactgggtgg ccgaggaacc gagcgtgccg accctgctgc tgcgggcgtc
     5641 ggagccgctc ggccgggtcg ccgacggcga ggagtggcac cccgactgga agttcgacag
     5701 cactgttctc gacacggaag gcgaccactt cagcatgatg gacgactacg cgccgcagac
     5761 cgccgcggcc gtgaacgact ggctggcggg cctcgtcggc ggcaagggct gagcggccat
     5821 ggcgactcac tccgcgggaa ccgcgcggac cgatgccccc gaccgccaat ggatacgccg
     5881 cttccaccca gcccccgacg cccccgtccg gttgctgtgc ctgccgcacg ccggaggctc
     5941 ggccagcgcc tacttcgggc tctcccagct gctcgcaccg aaggtggagg tgctggccgt
     6001 ccagtacccg ggccgccagg accggcgtga cgagctgctg ctcgactcga tcgcggcact
     6061 gcgcgccggg ctcgccgagg agctgacctc gtggctcgac cggcccatcg ccctgttcgg
     6121 gcacagcatg ggcgcggtgc tcgcctacga gacggcgcgc ctgctcgccg aggacgaacg
     6181 tgcccacctc gcccacttgt tcgtctccgg tcgcggcgat cccgcgcgca aggccgacgt
     6241 ggcactagac ctgctggacg accgggcaat ggtgcaagcc ctcggcgacc tcggcggcac
     6301 ggaccggcgg ctcctggagg acgaggacgt cctgcggatg gtcgcaccgg ccattcgcag
     6361 cgactaccgc gcggtccgca cgtaccggca cgcgcccgga ccgcttctgc cgtgccccgt
     6421 gaccgctctg gtgggcgacc aggacgccat ggcgccggtc gacgacgtgg agaagtgggc
     6481 ttcctacacc tcggcagaat tctccctgaa ggtttttcag ggcggtcact tctatttgct
     6541 ggaacagttc cggaaagtga gtgatcatgt gtacgatggg ctcggcgatt cgctctccgt
     6601 gcaagcgtcg cccggctgac ggattcaatt ccccactccg aactgcccga ctcattccga
     6661 aaaggcagca gcgctaagtt cttgtccact gcgccacctg cgccactgtg ccgccgcgct
     6721 ttcgcgcttc tcttctttcg aattcgctcc gaccggcacg agactgtatt cagacggggt
     6781 tctgcgtgca aaattctctt tacgaactgg gtgacatacc cccgatcggc accgtaccca
     6841 agcagatgta cgcctcggtg atccgccgag agcgctacgg gccgccccac caggcgttcc
     6901 ggaacgaggt cgtggacgtg ccggaggccg ggcccggcca ggtcctcgtc ctcgtcatgg
     6961 ccgcgggcat caactacaac aacgtctggg cgtccctcgg gcggccggtc gacgtgatct
     7021 cgtcccgcct tcagcagggc gagcgcgagg acttccacat cggcgggtcc gagggatccg
     7081 gcgtggtgtg ggcggtgggc gaaggcgtca gccaggtctc cgtgggcgac gcggtgatcc
     7141 tttccggctg ccggtggacc gagtcgtccg ccgacatccg cctcggtgcc gaccccatga
     7201 cctccgcttc ccagtcggtg tgggggtacg aaagcaactt cggctccttc gcccagttcg
     7261 ccctggtcga cgactaccag tgccacccca agccgcccgg cctgacctgg gaggaagccg
     7321 cctgcttcct gctcaccgga gccaccgcct accgccaact gtgcggctgg ccgccccacg
     7381 acgtgcggcc gggcgacccc gtcctcatct ggggcggcgc cggcggtctc ggctccatgg
     7441 ccatccagat cacccgcgca cgcggcggca tccctgtggc ggtcgtctcc gacgaggagc
     7501 gggcccgcta ctgccgtgaa ctcggcgccc aaggcaccgt caaccgcctc cacttcgacc
     7561 actggggccg gctgcccgac atcggcgacc gggcggcgat gggccgctgg accgagagcg
     7621 tacgggcctt cggacggagc ttctgggagg cgctggggga acgcaggtcc ccccgcctcg
     7681 tcctggagca cagcgggcag gacaccatcc ccacctccat gtatctgtgc gacaacgcgg
     7741 gcatggtcgt catctgcggc ggcaccaccg gctacaacgc cgacgtggac ctgcgttttc
     7801 tgtggatgcg gcagaagcgc ctgcagggct cgcacttcgc caatctccgc cagtgccgcg
     7861 acatcatcca catggtctcc accggacagc tcgacccctg cctttcgtgg accggcggat
     7921 tcgacgacat cggcaaggcg catcagctca tgcacgacaa ccagcatccg cagggaaatc
     7981 aagcggtcct ggtcaacgcg ccaaggaccg gaatgacgga acttccctga gtccggcgcc
     8041 gagcacaagt cggcgacttc tccattcttt tgcgatgaac aacgcttgaa cagcggaccg
     8101 aatcagagga gctctcatgg accagaacca gctcgacatc ctgtggagcg agcgcgagat
     8161 ccgcgccgtc ctgcagcgct actgccgagg cctcgaccgc ctcgacgagg aactcgtcaa
     8221 gtccgcgtat cacgaggacg cgtacgacga tcgcggcgtc atccggggca acgctcacga
     8281 cttcgtcaag cagatcgtcc cgatcctgcg ggacacatac accggcaccc tgcacaccct
     8341 gcacgggagc acgatcgagg tcgacggtga cagcgcgggc gtcgagacct actgcaccgc
     8401 ctaccactac cgcgagagcg acggcatcaa gcgggtcgag cagtttgccg gccgctacat
     8461 cgaccgcttc gagctgcgcg acggcgtctg gaagatcgcg cgacgggtcg tcctgaacga
     8521 cttcagcctc gcccaggagg tgccgctcga tcccgcagag gcccaggccg gcttcaaccc
     8581 gtcccggcgt gacgccaccg acgtcagcta ccaggtactt ccgctgagcg gcccggacgc
     8641 ccccacggtc tgagggcgcg ttcgaatccg tcgggtcact acgccgtgcg gtcccacgtt
     8701 cctggcaggc cgtattccca tcgacctcac actccaagga gttcagacgt gtccgagaca
     8761 gaccagcgcc cgcccacgct gcccaggcaa cgtacctgcc ccttctcacc gccgcccgag
     8821 ctggaggaac tgcgcggtac cgatcccatc agccggatga cgttcgccga cgactccgag
     8881 ggctggctgc tgacccggca cgccgacgtg cgcgctgcgc tggcctcccg gagtgtcagc
     8941 tcgcacccgg gcaggacacc gcagccgtgg cggaacctgg cgccggagat gcgcgcagag
     9001 gagtacctgc ccggcttcct gatcttcatg gacccgccga accacagccg ctaccgccgc
     9061 ctgctgacca agtggttcac catgcgcgcg attcgcaagc tcgaaccccg gatcgagcag
     9121 atcgtcagcg acgccctcga cgccatggag gccgagggcg gaccggtcga cctggtccag
     9181 tcgttcgcgc tgccgatccc cctgctcgtc atctgcgagc tgatgggcat ccgctacgac
     9241 gaccgtgtcg agttcatgga catggtgctg cggctccagg atctggaagc caccccggag
     9301 gaactggggg cgctcggcgc caagatgaac cagttcatga tcgacctgtg cgcggccaag
     9361 cggaagaacc ccggcgacga cctgctcagc cacctcatcc aggaccctga cgccgaaccg
     9421 gcactcaccg acctggaggt cgcgggaatc ggcgtcctca tgctcatcgc ggggcacgag
     9481 acctccgcga acatgctggg catcggcacc tacacgctgt tgcagaaccc cggccagtgg
     9541 gacctgctgc gcaacgacat cggcctgatc gaccaggccg tcgaggaact gctgcgccac
     9601 cagaccatcg tccagcaggg ccttccgcga ggcgtgaccg aggacatgga gatcgcgggc
     9661 cacgcgatca agcccgggga gacactgctc gcctcgctgc ccgcggccaa ccgcgacccc
     9721 gaggtcttcc cggaccccga ccggctcgac atcacgcgcg agcacaaccc ccacctcgcc
     9781 ttcggccacg gcatccacct gtgcctgggc atggagctgg cccgcgtcga gatgcgctgt
     9841 gcgtggcgcg gactggtcaa gcgctttccc gacctgcgca tggcggcgcg gatcgaggac
     9901 atcccgtggc gtgacgacca gatcgtgtac ggggtgtaca agctcccggt gacatggggc
     9961 gatgctccgt gaccggccag gtgacgaact cggtgacggg ccgggcgacc gacccggcga
    10021 ccgaagggag ccgctgcccc ttcgccgccg gcgaggcccc cgcctacccc ttcggcagcc
    10081 ccgaccgcct ggagccggac ccgtactggg aaccactgcg ccgagaacag cccctgcagc
    10141 gggtgacgct gccgtacggc ggcgaggcct ggctggccac ccggtaccag gacgtgcgca
    10201 aggtcttcgc ggaccgcagg ttctcgcgtg cgctcgccgt cgcgccgggc gccccccggt
    10261 tcctgccgca ccagccaccg gccgacgcgg tcctgagcgt cgagggcccc gatcacgcgc
    10321 ggctgcgccg gctggtcggc aaggtcttca cgccccgccg ggtcgaggcc atgcgcccgc
    10381 tgatccagag caccgccgac cggctgctcg acgccatgga ggagatcgga ccgcccgcgg
    10441 acctggtcga ggacttctcg ctgccgttcg ccgtctcgat gatctgcgag ctgctcggag
    10501 taccgcccga ggaccgcaaa cgcttctgca cctggtcgga cgcgctgctc acgaccaccg
    10561 cgcacacacc ggcccaggtg cgcgaccaca tgatgcagat gcacgactac ctcggtggcc
    10621 tcgtcgcgca gcgccgaacc cggcccaccg aggacctgat cggctccctg gtgaccgcga
    10681 gggacgcgga ggacaagctc accgagggcg aactggtccg cctcgccgag gcgatcctca
    10741 tcgccgggta cgagacgtcg gccagtcaga tccccaactt cctgtacgtc ctcttccgca
    10801 acccgcacct actggaacgg ctcaggaacg accacgacct gatcccggac gccgtcgagg
    10861 aactgctgcg gtacgtgccc atcggcacgg tcgacggctt cccccgcacg gccaccgagg
    10921 acgtcgaact cgggggagta ctgatcagag ccggcgagac ggtcgttccg tcgatgggcg
    10981 cggccaaccg tgatccggag ctgttcgccg acccggagga gctggacctg acccggagcc
    11041 cgaaccccca cctgggcttc ggcgcgggcc cgcaccactg cctgggcgcc caactggccc
    11101 gcgtggaact ccagatcacg ctgacgacgc tgttccgccg ctacccacgg ctgcgcctcg
    11161 ccgtccccga ggagagcctc tcctggaagg cgggcctcat ggtccgcggc atgcacacca
    11221 tgccgatcac ctggtgaaca cccctacgac cccgaccacc tgacgacacg agcgcacaga
    11281 gggtgaaacg acgcgaatga acgacgctat cgacgaacgg gaacacggcc cggaggacgt
    11341 tggcatggac cccgccgccc tgaagcggct gaccgaggtg gttcggtcga ggggcggcgc
    11401 ggcgcaactg tgcgtcatgc gacgggggac cgtggtcctg gaccgttcgt tcggctgctc
    11461 tccggactcc ctcttcctcc tgtacgcggc gaccaagccc ttcccggcgc tcgccgtgca
    11521 caagctcgcc gaaaggggac agctcgagct ggacagtccc gtcgccaact actggccgaa
    11581 gttcgcccgg cacggcaagg gcgaggtgac cgtccgccat gtcatgcagc atcgggcggg
    11641 ggtgccggtc ggccggggca tggtgcgcac gatgcgcacc gcccgggact gggagcgctc
    11701 ggtgcgcgat ctcgaggagt cgcggccccg ctggccgggc ggcaaggtcg ccgcgtatca
    11761 cttcatgagt tacggattca tcctcggcga ggtcgtgcag cgggtcaccg ggcagccgtt
    11821 ccgtgatttt gtgacgtccg agctgttcgc ccctcttggg ttgaatgatt tgcacctggg
    11881 attgccggac agtgcttggg gtcggcatgt gccggcgcgg gccgctcatc cgtccgaatg
    11941 gcccaaccaa tggatgagca acagtcgccg gtaccgccag gcggtcgttc catcggccgg
    12001 gctttccggt accgccgcgc aactggcccg cttttatcag atgcttttgg cgggcggggc
    12061 actcgaaggt gtccgcgtgt tgcaagccga gagcgtggca gaagcgagaa aaccgtccaa
    12121 tgaagggggg aacgacgcct cactgaaacg ccccgtccac tggtcccacg gattcatgct
    12181 gggtggcccc ggcccggacc cgcgggatct ggcccgagtc atgggcgacg cgagcgacgc
    12241 gcgcactttc ggccacgcgg gcaccacgtc cagcgtcgtg tgggccgatc ccgcacgcga
    12301 gttggtgttc gcctacctgt ccaacatcca gccggagttc ggcgcaggcg tcgagcggct
    12361 ccgagaggtc agtgacctcg cgctcgatgc ctgcgaggcg ggctgacgcg agtcgccgcc
    12421 ggtggcgggc cgccgaatcc caagggtgcg ccacggtcgt gtcccggcgg ggcggggcgg
    12481 tccggcccgg gcgcccaccc cgcccgcgcg gagacggatt cctccagccg tccccgggtg
    12541 tcgcgccgcc ggccgctctg tcgcccctgt gtgaaacccg gctgaaacaa gtcggtcccg
    12601 gtgacggtga tctaccgcac accatggccc gcggctcgga aagtccttga tcacaatgga
    12661 tgtcaatgta agtatgttca tccatcaccc gttattccgg catgtcgggt gcagggggct
    12721 ctccggagga ggggcgatac tgatgatgcc taattggata gaacattcag agtcaaaatt
    12781 cccaccacgg gtgggaatac taggaccgtt agaagtccgc ttcgccgaga attcgggatc
    12841 gggcgtttcg gtaaatggta ttcgcgttcg tgcattactt gccgcgttga ccgcgcagct
    12901 gggggaggcg atgtcgaccg agcgaattct caaggaagtc tgggccgaca acccgcccgc
    12961 caccgaccgc aaggcggtgg ccgtggccgt cctgcggctc cgccgggtcc tcgacgaccg
    13021 cgatgggcag tggctgctca cccgcccgtc cggatacgtc ctggccatcc ctccggacca
    13081 tcttgacgcc gcaagagcgg agcgcttggt gcgggaaggg aaggcggccc tgaccgcagg
    13141 tgaccctcgc gtcgcgtccc agtcgctcag gcacgcgctc gcccagtggc gcggagaacc
    13201 atacgccgac gcccacgcca ccgcggcggt ggtccggcgc acgagcgaat tggaaagcct
    13261 caagtgcgag gccgtccagg cccgtatcga cgccgacctc gaactggggc atcatcagga
    13321 actggtcggc gagttgcgct ccctcaccgc cgcgaacccc ctgcacgagc cgcactggct
    13381 gcagttgatg ctcgccctgt accggtcggg cagacaggcg gagtcgctaa gcgcctacat
    13441 ggacgtccgt caggcgctcg ccgagaaact gggagtggat ccggggcggc cgctccagga
    13501 gctgcatctg cggatactgc gcgccgacgc cggactgttg tacgggtcgg cgagctcggt
    13561 gtcgtcgcaa ctgctgctgg ccggccggtc ctaggccgtg tcgacccccg cccggggggc
    13621 cggggcccgg ccgccgagtg cccaccctcc cgcgccccgg tttcgggcga cggccgtggg
    13681 aagccgaaca gacggaggcc tgctgattct ggcggattct gccttcccgc atcggcgtcg
    13741 ccgggtcgcg tgacgacccg caggaggcag tgccgtaccc ggaggaagcg gtcctcgtga
    13801 gcaacgcggt cgacgcgcga cgccgggagt tcaccaccgt ccgacactgc gcgcggcggg
    13861 cgatgtgcga accgggcctg cctggtgccc cgtactcccg gaaggcacga tgctccctga
    13921 cggccgcccc ggaccgtggg aagccttacg cactgtgccg ggcaccgggc gctccagggc
    13981 ggtggccgct gagcgagggt gtgatcctca ccgccgtcgc ggtgcccgcg ccttcctgca
    14041 gcccggggga gttcggaacg agaagtgaag acagtcctgg agggaatcga aatgcccgct
    14101 gaggagctga cggacagctt ccggaatgcc atgtcctcat tcccgagtgg ggtgacgatc
    14161 gtgacaaccg tcgactccga aggggagtgg tggggcttca cagccacatc gttctgctcg
    14221 gtgtccctcg atccgccctt ggtgctggtc tgtctctccg tcgaagcaca gtgtcaccct
    14281 gccttctcga ccgcgacatc gtgggtggtc cacatattgc cgcccagaca tcgagagctc
    14341 gctctgtggt tctcctccaa aggtgtcgac aagttctcac ggggcgattt cacgacgaac
    14401 gcccagggcc atccagttct tgaggggacc tgcgcggtgc tggaatgcga ggcgagcgcc
    14461 cggtacggcg ggggcgatca ctccatcctc gtgggtgagg tgaccaggtc ccatgtccac
    14521 gacgacgagc ctgcggtgta cttccggcgc aaattccaca ccctcacacc gttgttggag
    14581 acgaccacgt ccgcctgaga gccgggaggc agacgcggtc atgaccacag agcccggggc
    14641 ccggtccacc actgcggcgg accgggcccc gggaagcctg ctcaggcgga tgccggcggg
    14701 tacagcgagc gcggcagttt cgacgcagcc gccgcgtcca gcagccacag cgtccgggcc
    14761 cgcccgtacg ctccagccgc cggcgcctgg atctcgcccg cgcccgacag cgcgatctcc
    14821 gccgccttcg ccttgtcctc gcccgctgcg agcagccaca cctcacgcgc cgcgcggatg
    14881 gccggcaggg tgagcgagat acgggtcggc ggcggcttgg gagcgccgtg gacgccgacc
    14941 accgtgcgct cggtctcgcg gaccgccggt agttcgggga agagcgacgc cacgtgcgtg
    15001 tcgggcccga ctcccagcat cagcacgtcg aacgtcggca ccggaccgtg atcctcaggg
    15061 ccggccgccg cggccagttc cgtcgcgtag gcggcggccg ccgagtccac gtcggagccg
    15121 tacgcgccgt ccgacgcggg catggcgtgc acccgcgacg ggtcgagcgg tacggcgtcg
    15181 agcagggtct cacgggcctg ggtggcgttg cgctccggat cgccttccgg caggaaccgc
    15241 tcgtcgcccc accacagatc gagccgcgac cagtcgatcg cgtccctggc cggggacgaa
    15301 ctgagcgcgg ccagcaggcc gttgccgttg cggccgccgg tgaggaccac cgaggccgag
    15361 ccgcgcgcgg cctgtgcgtc cacgatcttc gtgatgagcc gagccgccgc ggcctgcgcc
    15421 atcaactcct tgtcgcggtg gacgaccagc tgcggtgccg cggtcacttg gcggccgcct
    15481 tcttggctgg ggcagccttc ttggccgcgg gtgccgccgg cgccgccttc tccgcgggtg
    15541 caggctgcgg agccgcagcc gggcccgcgc cgaggcgctc cacgccgtac cgcagtgccg
    15601 acgagtacgt gtcgtccggg tccagcctgc gcagctcctc cgcgatcagc tcggccgtct
    15661 cacgccgctt gagcgccacc gcacggtccg gctggccctc gatggacagc gtcgcgagag
    15721 acccgtcggg ccggtcgagc acgatcgggc cgcagtcgga ctccatccgt accgaggtga
    15781 gaccggggcc ggccgacgac gtccgcttca ccggcacgtc cagccggtcc gcgagccaca
    15841 tcccgagcag ctcgcagctc gggttgaact cctcgccctc cacctcgacg gacgtgacct
    15901 cgcagtcgac ctggtccagc gccgccgcga gcatcgagcg ccacggtgtt atccgggtcc
    15961 aggacaggtc ggtgtcaccg ggggcgtagg cctccgcgcg ggccgccagc tcgcgcaccg
    16021 gctgttcggc cgcgtaggtg tcggtcaccc ggcgctgggc cagtgcaccg agcgggtcgc
    16081 tggccgggtc ggtcggcgcg ttgaccggcc accagacgac gacgggtgcg tcgggcagca
    16141 gcagcggcag caccacggac tgggcgtggt cgacgacctc gccgtacagc cgcaggacga
    16201 ccgtctcgcc cgtgccggcg tccgcaccga cgcgcacctc ggcgtcgagc cgggccttgg
    16261 cccggtcgcg cggggagcgg gagacccgct tgatgaccac gagggtgcgc gaggggtgct
    16321 cgcgggaggc ctcgttggcg gccttcaggg cgtcgtaggc gttctcctca tcggtcacga
    16381 tgaccagggt gaggaccatg ccgacggccg gggtgccgat cgcacggcgg ccctgcacca
    16441 gcgccttgtt gatcttgctg gccgtggtgt ccgtaaggtc gatcttcatg gccgacgcca
    16501 gctccgtccg tctcgtgcga gcatttcgtc cgcctcggcc ggcccccacg tgcctgccgg
    16561 gtactgcgcc ggcttgccgt tcgcgtccca gaactgctcg atcgggtcga ggatcttcca
    16621 ggaaagttcg acctcctcga cacgtgggaa gaggttcgag tcgccgagaa gcacgtcgag
    16681 gaggagccgc tcgtacgcct cggggctgga ctccgtgaac gactcgccgt acgcgaagtc
    16741 catcgagacg tcccggacct ccatcgaggt gcccggcacc ttggagccga accgcatggt
    16801 cacgccctcg tccggctgga cgcggatgac cagggcgttc tgtcccagct cctccgtggc
    16861 ggtggagtcg aacggcgagt gcggggcgcg ctggaagacg accgcgatct cggtgacgcg
    16921 gcggcccagc cgcttgccgg tccgcagata gaaggggacg cccgcccagc ggcggttgtc
    16981 gatctccagc ttgatcgcgg cgtaggtgtc cgtcttcgac ttggggtcga tgccgtcttc
    17041 ctgcagataa ccgacggcct tctcgccgcc ctgccagccc gccgcgtact gcgcgcggac
    17101 cgtgtccttc gccaggtcct tcggcagctt caccgcgccg aggaccttgg tcttctcggc
    17161 cgcgagggcg tccgcgtcga aggaggcggg ttcctccatc gcggtcagcg ccagcagctg
    17221 gaggaggtgg ttctggatca cgtcacgggc ggcgccgatg ccgtcgtagt agccggcgcg
    17281 gccgccgatg ccgatgtcct cggccatcgt gatctgcaca tggtcgacgt acgaccggtt
    17341 ccatatgggc tcgaagagcg tgttggcgaa ccgcagcgcc aggatgttct ggacggtttc
    17401 cttgcccagg tagtggtcga tacggaagac ctcgttcggc ggaaagacct cgtgcaccac
    17461 ctggttgagc tccttggcgg agaccaggtc gtggccgaac ggcttctcga tgaccgcgcg
    17521 ccgccaggag ccctccttct ggtccgccag cccgtgcttc ttcagctgct ggacgacctt
    17581 ggggaagaac ttgggcggca cggagagata gaaggcgaag ttgccaccgg tgccctgcac
    17641 cttgtcgaga tcctcgatgg tggacttcag ctgctcgaaa gcgtcgtcgt cgtcgaaggt
    17701 gcccgggacg aaccgcatcc cctggatgag ctgctgccag acctcctccc ggaacggcgt
    17761 acgcgcgtgc tccttgaccg cgtcgtggac ctcctgcgcg aagtcctcgt cggcccactc
    17821 gcgccgggcg aagccgatga gcgagaagcc cggcggcagc agccctcggt tcgcgaggtc
    17881 gtagacggcg ggcatcagct tcttgcgcga cagatcaccc gtgacgccga agatgaccag
    17941 gcccgacggc cccgcgatac gcgggagccg tcggtcggca gcatcacgga gcgggttggc
    18001 tccgccaata ccggacaagt cgctcagcct tccgagggtg cgaggcgctt gagctcagcc
    18061 tcggtcgact tgagcaggtc gttccaggac gcctcgaact tctccacgcc ctcgtcctcg
    18121 agcagctgaa cgacgtcgtc gtaggagatc ccgagcttcg cgacggcctc gagctcggcg
    18181 cgggcctgct cgtaggtgcc gcgcacggtg tcaccggtga tccggccgtg gtcgccgacg
    18241 gcctcgagag tggcctccgg catggtgttc acggtgcccg gcgcgaccag gtcgtcgacg
    18301 tacagggtgt ccttgtacgc cttgtccttg actccggtcg aggcccacag cggacgctgc
    18361 ttgttggcct gcgccttgtc gagcacggcc cagcggtcgc tgctgaagac ctcctcgtac
    18421 gcctcgtagg cgaggcgcgc gttggccacg gccgccttgc cgcgggcctc cttggcctcg
    18481 ggggtgccca gcgcgtcgag acgcttgtcg atctcggtgt ccacgcggga cacgaagaag
    18541 gaggccaccg agcggatctt ggacaggtcc aggcccgcgg ccttcgcctt ctccagaccg
    18601 gccagatagg cgtccatgac ctcgcggtag cgctccagcg agaagatcag cgtgacgttg
    18661 acactgatgc cgaggccgat gacctcggtg atcgccggca gacccgcctt ggtggccggg
    18721 atcttgatga aggtgttcgg ccggtccacc agccaggcca gctgcttggc ctccgcgacg
    18781 gtcgccttcg tgttgtgcgc gagacgaggg tcgacctcga tcgagacacg gccgtcctgg
    18841 ccgccggtcg agtcgaacac cgggcgcagc acgtccgcgg cgtcacgcac gtccgccgtg
    18901 gtgatcatgc ggatggcttc ctcgacggtc accttgcggg ccgcgaggtc ctccagctgc
    18961 tggtcgtagc cgtgaccctc ggagatcgcc ttctggaaga tcgacgggtt cgtggtgaca
    19021 cccacgacgt gctgctggtc catcagctcg gccaggttgc ccgaggtgat ccgggtacgc
    19081 gaaaggtcgt ccagccagat cgcgacgcct tcgtcggaga ggcgcttgag tgcgtctgtc
    19141 atgagaaatg catctcctac ttgtcgtata ccggcgtcag cgcgcggcgg cgtcgatcga
    19201 ttcccgcgca gcagcggcga cggcctctgc ggtgaagccg aactcgcgga agaggacctt
    19261 gccgtcggcc gaagcgccga agtgctccag cgagacgatg cgcccggcgt cacccacgta
    19321 ccggtgccag gtcaggccga taccggcctc gacggccacg cgcgccttga gcgacggggg
    19381 aagcaccgag tcccggtacc cctggtcctg ctcctcgaac cactcgacgg acggcatcga
    19441 cacgacccgg gtcggcacac cggccgcctg gagctgctcg cgggccgcga cggccagctg
    19501 cacctcggag cccgtgccga tgagcacgac ctgggcgtcg ccgccctctt cctcgagcag
    19561 gacgtagccg cccttggccg cgtcctcgtt gcactcgtac gtcggtacgc cctggcgggt
    19621 cagcgcgagg ccgtgcggag cgcccttgcc gaattccttg gtgtaccgct tgaggatctc
    19681 gcgccaggcg atcgcggtct cgttcgcgtc ggcggggcgc acgatgttca ggcccgggat
    19741 ggcgcgcagc gaggccaggt gctccaccgg ctggtgggtc gggccgtcct cgccgaggcc
    19801 gatcgagtcg tgcgtccaca cataggtgac cggcaggtgc atcagcgagg agagccggac
    19861 cgcgttgcgc atgtagtcgg agaacaccag gaaggtgccg ccgtagatgc gggtgttgcc
    19921 gtgcagcgcg atgccgttca tgactgcggc catcgcgtgc tcacggatgc cgaagtggac
    19981 cgtgcggccg tacgggtcgg cctccggcag cgggttgccg gcgggcagga acgacgacgt
    20041 cttgtcgatg gtcgtgttgt tcgagcccgc caggtcggcg gagccgcccc acagctcggg
    20101 cacgaccggg ccgagcgcct gcagcacctt tccggacgcg gcgcgggtgg cgacgctctt
    20161 gcccggctcg aactccggca gcgcgtcctc ccagccctcg ggcagctcgc ccgaacggat
    20221 ccggtcgaac tcggcggcac gctcagggtt ggccgtacgc caggccgcga acaccttctc
    20281 ccactcgccg cgggcctcac ggccccggtc gagcgcgccc cgggtgtggt tcaggacctc
    20341 gtcggcgacc tcgaagtgct gctcggggtc gaagcccatg acccgcttgg tggccgcgac
    20401 ctcttcctcg cccagcgcgg agccgtgcgc ggcctcggtg ttctgcgcgt gcggggcggg
    20461 ccaggcgatg atcgagcggg ccgcgatgaa ggaggggcgc tcggtctcgg cctgcgccgc
    20521 cttcagggcg ttgtggaggc cgaccgggtc gaggtcgccg ttctccagct gctggacgcg
    20581 ctggacgtgc cagccgtacg cctcgtagcg ctggagtgtg tcctcggaga cggccgtctc
    20641 ggtgtcgccc tcgatcgaga tgtggttgtc gtcccacaga aggaccaggt tgccgagctt
    20701 ctggtggccg gccagggagg acgcctcggc cgagatgccc tcctggaggc agccgtcacc
    20761 ggcgatgcac cagacggtgt ggtcgaacgg cgacgtgccc ggagcggcgt ccgggtcgaa
    20821 caggccgcgc tcgtaacgag cagccatcgc catgcccacg gcgttggcga caccctggcc
    20881 gagcggaccg gtcgtcgtct ccacccccgt ggtgtggccg tactcggggt ggcccggggt
    20941 cttgctgccc caggtgcgga acgccttcag atcgtcgagc tccaggccgt agccggccag
    21001 gtagagctgg atgtagagcg tcagcgacga gtggccggcg gacaggacga acctgtcccg
    21061 gcccgtccag tcggcgtcag cgggatcgtg ccgcatcagc ttctggaaga gcacgtaggc
    21121 ggcgggggcc aggctcatgg ccgtacccgg atggccgttg ccgaccttct gtacggaatc
    21181 catggccagg acgcggacgg tgtcgactgc ccgctggtcc aacgcggtcc actcgaggtc
    21241 tgtggtggtc ggcttggtgc tcaccctgag tcagggctcc tctccacatg tcgaatcccg
    21301 gcgacgaggg gtgtaccggg cgctgtcgag cctaccctcg cagcaacgca cctctttgcg
    21361 gtcgcgcgtc tttcccattg gacactgcca gggtgcgggc agcgggtgct ccgtgcctct
    21421 cggcggtgta tacggcccgt gtcctgccac cgctcaacac gagccgaccc cggcgaagat
    21481 cggtgtacgg gcaacgtcta gagtggcgtg gtacgcgcga gtctttaccg ggccttcaca
    21541 ccggtcgact cgctgggatt tctctgtcag gggtgtgcgt gacggccgtc gagtcccgac
    21601 ccgcaggggt cgtcttggcc accggcccgg ggggccatcg gccgttcggg gcccgcgtca
    21661 aggcattcgt ggcgctgacc aagccgcgga tcatcgaact gctgctgatc accaccgtgc
    21721 cggtgatgtt ccttgccgag cagggcgtcc ccgacctgtg gctggtgctc gccacctgcc
    21781 tcggcgggta cctctccgcg ggcggcgcca acgcgctcaa catgtacatc gaccgcgaca
    21841 tcgacgccct catggaccgc acgtcgcagc ggccgctcgt caccgggatg gtctccccgc
    21901 gcgaaggcct cgtcttcggc ctgacgctcg cggtggcctc caccctctgg ttcgggctgc
    21961 tcgtcaactg gctgtcggcc gcgctgtcgc tcggcgccct gctgttctac gtcgtcgtct
    22021 acacgatgat cctcaagcgc cgtaccgcgc agaacatcgt ctggggaggc atcgccggtt
    22081 gtatgccggt cctgatcggc tggtcctcgg tcacgaactc gatgtcgtgg gccgccgtcg
    22141 tcctcttcct cgtcatcttc ttctggacgc cgccgcacta ctggccgctg tcgatgaagg
    22201 tcagggacga ctacgcgcgg gtcggcgtgc cgatgctgcc cgtcgtcgcg ggcaacaagg
    22261 tggtcgcccg gcagatcgtc ctctacagct gggtcatggt cgccgtctcg ctgctgctca
    22321 ctccgctcgg ctacaccggc tggttctaca ccgcggtcgc actggccgcc ggcggctggt
    22381 ggctctggga ggcgcacgca ctgcagacca gggccaacgc gggcgagagg ggcggcaagc
    22441 tcaaggagat gcggctcttc cactggtcca tcacctatgt gtcgctgctc ttcgtggccg
    22501 tcgcggtgga ccccttcctg cgctgagtcc cgccccgggc acggcgtggc cgaggccacg
    22561 tctcccggcc gtcgccaggt gatctacccc cgagtagcat gcggtgcatg gctgaaacaa
    22621 aggttgatga gacggcgtcc gcgcccgcgc ccgacgcccg cgccgaacgc aaggcggcga
    22681 aactcgccaa gcagatccag gcgttctcca aggcgcacgg cggcgccgag ggtcagctcg
    22741 cctacatcgg ccagaggggc acccgcatcg tcctcgtcgg cgaggacggc ggctggggcg
    22801 acctggtggc cccgagccac gccatcgccg tcagcgccgc ggacaagtcg gggatcacgc
    22861 tgcacgagtc gttcgacggt gacttcgccg cgaaggtgcg caccggcccg tacgagtgga
    22921 cccgcatggc gggcatccag gtcggcggcc cttccaacgg ctgagcaaca ccttgcgcgg
    22981 ggtggcccgt tagtcctgtg gaagtacggt ccacaggcag gagctcccga tgatcgacgc
    23041 cgcgtcctcg gtgcgtctgg tcgaccagta ctgccacggg gtgctccgca cggaactggg
    23101 catcggcacc ttcgagacgt acctgggtcc tgtggccggc gccccgccgg ccgcaggcac
    23161 caccttcttc gacacccaga cgggtttcgc ggtacggcgc tggtgcccgc cgctcctcgg
    23221 actcgaaccg cactgcccgc ccgcccacta cctggcccgc cgccgcgaac tcggggcggt
    23281 cgaggcgggc agacggctgc tgcgcggcac cgggatcgcc acgtacctcg tcgacaccgg
    23341 cccgcccggg gacctggccg gcccggcgga gatcgccgcg gcggcggagg cgcaggcgcg
    23401 cgagatcgta cggctcgagc tgctggccga gcaggtcgcc gacacgtcgg ggaccgtgga
    23461 gtccttcctc acgaacctcg cggaggcggt acacggggcg gccgggtccg ccgtggcctt
    23521 caccaccgtc gccgccgggc ggcaggcgga ccggccggag ccgccgggga cgggcgaggt
    23581 acgcggcgcg gccggacgct ggctcgccga gcgccgtgtc ggggagccgc tcaccgaccc
    23641 cgtactgctg cggcacctgc tgtgggtcgc cgtcgccacg gggctgccgc tgcaactgca
    23701 cctcggtgag ggcgacccgc tgccgctcgc ggacttcgcc gcggcgacgg ccggcctcgg
    23761 cacggacctg atcctgctgt acggctaccc gcaccaccgc ggcgccgcgc acctcgcgag
    23821 cgcgtaccag cacgtctacg ccgacctcgg ccctgccctc gcccggacgg gcacgcgggc
    23881 ggcggcggtg ctggcggaga ccctcgaact cgcgcccttc ggcaagctgc tgttctcgtc
    23941 cggggcacgg ggcctgccgg aactccatgt ggtggccgcg tgcaccttcc gcgaggcggt
    24001 ggaccgggtg ctgggcgggt gggtcgcgga cggagcgtgg tcgcgggccg acgcggagcg
    24061 ggtggcgggg ctgctggggt ggggaaacgc ggggcgggtg tacggcctgc cctagcgggc
    24121 cgtggcccgg agcccggtac gccctgcgac gcgccgtacc gcggcggggg tggagccgca
    24181 gcgccgcgcg gagcgcgtgc gatccggtgg ggttccgggt gccgtccgga gggtggcacc
    24241 gggtgcggga cttgcaccac cacgcggcgg agccctcgaa tcggcccagg ggagaagctc
    24301 gtgcggcgga gccggtcagg cggaggtcag agccgggtcc ggcgacgccg gtgccggtgc
    24361 cggcgtcgac tcacgctccc gcaggctcag cgccagcctc agcaccgcga tccacatcac
    24421 cgaagacccg agcatgtgcg ccgccaccaa cagctccggc acgcccgtga agtactgcac
    24481 gtagccgagc gccccctgca acagcacgac cagcagcagg tcacgagcgc gggcccggat
    24541 gtcgtccggg gcgtcgacca cgcggaggac gagccacatc gcgacggcca gcgcgcacac
    24601 cacccacgcc gcgatcgcgt ggacgtgcgc cgccgctgac cagtcccacg gcatccgcgg
    24661 gacgtcgctg ctgtcgcccg cgtgcttgcc ggagccggtg accgtcgtgc cgagggtgat
    24721 cagcaccgcg gagaccgcga cgatcgccca cgagagcttg cggaccggcc gcgggacccg
    24781 cggtcggggt gcgccgtcgc cctcaccggt acgcacccat gtggccgtcg cgaccgtgag
    24841 cagcgcgttg gccaggagga agtgcccggc caccgtccag gggttgagac ccgcccacac
    24901 cgtgacgccg ccgatgacgg cgttgcccat gacgatccag aactgcgccc aggcgagccg
    24961 gcccagaccg cgccgccgcg gcttggtggc gcgcacggcg atgatcgccc agccgacggc
    25021 cgccgacagg acgtacgtca gcatccggtt gccgaactcg atcgcgccgt ggatgccctg
    25081 ctcgggcgtg gcgaagaggc tgtcgtccgt gcacttgggc caggtgtcgc agccgagacc
    25141 ggagccggtg agccgtacgg cgccaccggt gacgatgatg aggacggtca tcaggacggc
    25201 ggaaagcgcg gcgcgccgaa ggattttggg cgacggtgtc cagcgctggg cgatatgggc
    25261 gaggggggtc tgcacggccc ctatcgtaag cgggggtttg tgcacggttt cacgaggggt
    25321 cggcagcggg ctcccgggcg ggctcgccga aggcttcgga cgtcatacgg acccgggacc
    25381 cgtcgaggtg gtcctcctcc tcccaccaca gcgcgaaacg ccatggtgtc ggagcgggcg
    25441 gcgcgtccgc cgatgtgacg aaggcgtccg tcagctcggc ggccacctcc tctgccgtgc
    25501 agtcggtgac cgcgtccatg ccgcgccacg ggtgggccag cggcacccat ctgccgtcgg
    25561 ccctccgtat gtcgaagcgc cataccgccc gccaggacct cgcgcgcagg atccggccga
    25621 cctcggcccg ttcgaggccg agcccctgcg cgatcgactc cggtgcgacg ccctcgatcc
    25681 gcgccgccag gaccgcgagc ggcaacagtc gctcgggcag cagctcgcgc ttgtgcagct
    25741 gggtgaggcc accttcgaag gggcagcgcc gcagcctgcg ctcgagttgg tcgccgaggt
    25801 gctccaggac gg
//
