LOCUS       NZ_BMWB01000021        29149 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence21, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000021
VERSION     NZ_BMWB01000021.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 141211)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 112062
            Orig. end                         :: 141211
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29149
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="HR-T2PKS"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..29149
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="HR-T2PKS"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..29149
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20000:22384](-)"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..22384)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
     gene            292..851
                     /locus_tag="IE198_RS26380"
                     /old_locus_tag="GCM10010381_53500"
                     /pseudo=""
     CDS             292..851
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947753.1"
                     /locus_tag="IE198_RS26380"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53500"
                     /product="sugar O-acetyltransferase"
                     /pseudo=""
                     /sec_met_domain="Mac (E-value: 1.3e-14, bitscore: 47.4,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGENKDRMLAGEWYLPDDEELGADTRRRFELCAAYNAYGGADPAG
                     RGAILAELIGSLGKDVRIRPPFQCDYGRCITIGDRTFINYQAVFLDAAPITIGSDVQTG
                     PGVQLLTPPTTWTRSAVARAGRRRPRSRSATTSGSAAA"
     gene            complement(841..1038)
                     /locus_tag="IE198_RS26385"
     CDS             complement(841..1038)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189890859.1"
                     /transl_table=11
                     /translation="MGSSVAAGSDNAVAVGAGDHASSSSPDRLRRSGSRTAGRVRSPSA
                     ATAQGSNATGHARGKLVITR"
     gene            1037..2722
                     /locus_tag="IE198_RS26390"
                     /old_locus_tag="GCM10010381_53520"
     CDS             1037..2722
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006261 - DNA-templated DNA replication
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577721.1"
                     /locus_tag="IE198_RS26390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53520"
                     /product="bifunctional 3'-5' exonuclease/DNA polymerase"
                     /protein_id="WP_189890861.1"
                     /transl_table=11
                     /translation="MGGRWALAAAEGGGARLVPLGPDGLPSGPVLEEPDLVEAVRSRPE
                     VGRWVWRSTAEIYPRLLAAGVRVERCYDIEDAELLLLGHEGRLGEPRSAAAAWARLHNA
                     PVPPDPPARAAEPGSQSSLFEPQPVTVPLEALLEVYAEQQRRHAAAEHPGRMRLLTAAE
                     SAGMLVAAEMSRAGLPWRADVHREVLHELLGERYAGGGEPRRLAELTEEVSAAFGRRVR
                     PDLPADVVKAFARAGVKLRSTRHWELAEIDHPAVEPLIRYKKLYRIWTAHGWGWLQDWV
                     RDGRFRPEYLPGGTVSGRWTTNGGGALQIPKVIRRAVVADEGWRLVVADADQMEPRVLA
                     AISRDRGLMEVAGHDGDLYTALSDRAFSGDRAHAKLALLGAVYGQTSGDGLKNLAALRR
                     RFPRAVAYVDDAAKAGEEGRLVRTWLGRTSPRAIGAGDDDEAGIPQETLETTPAEDGFT
                     PGYASANARARGRFTRNFVVQGSAADWALVMLAALRRATSAMRAELVFFQHDEVIVHCP
                     AEEAEDVAEAIRSAGELAGRIAFGETPVRFPFTIAVVERYSDAK"
     gene            complement(2749..4014)
                     /locus_tag="IE198_RS26395"
                     /old_locus_tag="GCM10010381_53530"
     CDS             complement(2749..4014)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53530"
                     /product="hypothetical protein"
                     /protein_id="WP_229834337.1"
                     /transl_table=11
                     /translation="MPFEDDLGAAMRRTGETFGPSDRPGLVDGGLIRGRRRLARRRAVA
                     VTGSVLALTVVGVTGGYTTGALGSDGGRSSAAASAGPTAPASDSASAPAEAGGVTLKEM
                     IETFKGLLPEGRTIREDGSGITKDPEGGLHGPYVHLVFDDGRGAAAMGLGVSVVDPTGQ
                     GAADSVTCPSQALMPHDACQEETLSDGSRYMLFQGYEYPDRREDTKVWRATLVTPKGVK
                     VDASEWNARAEKGAQVSRPTPPLMATQMKALVTNEVWRTIGAQLGKPREETPPPGRPDG
                     AAVNKVLASLLPGNLEIVDQQGDPGYGFVVADDGRGASFIQVNAQTGMADLAQDVFAGD
                     VTTLPDGTKVMVKKENDPDQKGGAGVVGWTVDTLRPDGFRVVMTAFNAPGQGKDASRAE
                     PVLSIEQMRTVVLDEKWRTAAG"
     gene            complement(4088..4597)
                     /locus_tag="IE198_RS26400"
                     /old_locus_tag="GCM10010381_53540"
     CDS             complement(4088..4597)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968236.1"
                     /locus_tag="IE198_RS26400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53540"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_189890863.1"
                     /transl_table=11
                     /translation="MRASRTEEYREFAANRAAHLYRSACLLTSGDTHLAEDLVQETLGR
                     MYMLWGRVSRIDNPAGYAQTVLVRSFLTYRRRRSASERPVGELPDCALLSGDDPELRLA
                     LLGALGRLSPKDRAVVVLRYWEDRSIEETADAMNVSSAAVRTRAVRALAKLREQLGGSL
                     VEFAAR"
     gene            complement(4854..5243)
                     /locus_tag="IE198_RS26405"
                     /old_locus_tag="GCM10010381_53550"
     CDS             complement(4854..5243)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53550"
                     /product="hypothetical protein"
                     /protein_id="WP_189890865.1"
                     /transl_table=11
                     /translation="MTEPSEVMWSVAAFAALSGAFYVFLRWATAPLLAHLGVGVEYALN
                     VVVVGLLMPEYWFTRVQRRISGHAAPFAYTYGDAVCALAGGGHRCAGAVLSALYEGAAR
                     LGHRGSLGVGTVAAAVVVLSGTQWQ"
     gene            complement(5240..5851)
                     /locus_tag="IE198_RS26410"
                     /old_locus_tag="GCM10010381_53560"
     CDS             complement(5240..5851)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53560"
                     /product="hypothetical protein"
                     /protein_id="WP_189890867.1"
                     /transl_table=11
                     /translation="MRQETRRFAIERSAAAEAAVMDALAAVPLAAAEGLEIHCQIRLSL
                     DEEAVRQYSSLRSIDYARATTTSEHELTRLRTQNEQQLMDERTRFYAQMLAQGDVERWG
                     LHLAENPRDIPLAIEGIRDDEREASANQVHIIEKLLDAGVLEDHMLEEPARVALESLKA
                     RLADAAQGRTRKQPLYREQLEAGHSRQDAEKGGDGQGEPG"
     gene            complement(5870..6283)
                     /locus_tag="IE198_RS26415"
                     /old_locus_tag="GCM10010381_53570"
     CDS             complement(5870..6283)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53570"
                     /product="hypothetical protein"
                     /protein_id="WP_189890869.1"
                     /transl_table=11
                     /translation="MEQRFPGADQVPEAPVAHPVHPAVMNDPVRNVRTLHRFEFVRHRP
                     PAFAERALVFLTSGGRPQTYLPHQQPTRGELVSKNFRTLYEVEMGIQHLSFDHRLPSDG
                     DAFFFSAETDLTWRVVDPTAVVEKRVRDVRALI"
     misc_feature    6268..6282
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.56"
                     /tool="antismash"
     gene            complement(6323..8509)
                     /locus_tag="IE198_RS26420"
                     /old_locus_tag="GCM10010381_53580"
     CDS             complement(6323..8509)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53580"
                     /product="hypothetical protein"
                     /protein_id="WP_189890872.1"
                     /transl_table=11
                     /translation="MKENVRGNVEQDAKGAREPEDRSTPQEAEDEGGEARGTDVVPEAW
                     EAVEQLFTLAPHLRAERANVLGDTQVDGDVVGGDKHVHVHTGEGRSRLRPVGPVPAEEL
                     NRLETTFAPTRRYDEACAKLSDARVLVLRGRQGTGRRTAALRMLIHARKRGSEVIALDP
                     GTEPAEFADHIRPGAAHLVVDPPTGGDRPLRDVHMHAVRMRIADSGGLFIAVTSPDTVV
                     DGAVTVDWTPPPAADVVRAHLTVRLAARSTGPSHSHDTGPVARSAQDRVSEECARLLDL
                     EETRNYLRERPTPGEAADFARLLAAHADGRAGTDALAVYGRSSAEALADTWFSSTGPDL
                     RDKAFLISLAAFDGSPYPLVAEFGDALFRSMQSVEGPDGPGGHPVFGTSRSARLALARA
                     HERDRKTDTPWGTLPERVVAFENSGAWAAVLEHVWMSHPAARLPMLEWLDTLASDSRAL
                     VRLRGAVVAGVLACADFGYAFDRLIAPWASSDRLMERQLAAWSLYTAAARGMDMVVRRL
                     LSDWSRQGSQGRRWTVVRTYALLGDASASTALREIARMASTGTTPDQALWSALVQTVET
                     LLHGPAQKESLAALKQWGQSPGNLRQLAGEGFLRAAGRHTYQPAAGCTGPRLLWSADQD
                     PVVGEQVTALWRHVLDDRELRRDALTVLASWVRAAREPAVEAAVARLLPDLVTTANDRD
                     RLDHLLRKIRDEDSSNGAAEHLRARLPSVSAPSR"
     misc_feature    complement(7646..7648)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8114..8116)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8511..9308)
                     /locus_tag="IE198_RS26425"
                     /old_locus_tag="GCM10010381_53590"
     CDS             complement(8511..9308)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53590"
                     /product="adenylate/guanylate cyclase domain-containing
                     protein"
                     /protein_id="WP_189890874.1"
                     /transl_table=11
                     /translation="MTEPSNRTILLMDIEGSGSRTDVEQAVIRRMLYAVLRETLSAAFV
                     EATEYRSEDRGDGVFVLIDPGVPKPALIRALLTTTPMRLRSNNRLAAAGSQVRLRLVVH
                     TGEVALDEYGAVGADVVLAFRLLDSKGLKDALAATTEPSVLCVSDPVHHGVVRHGHHGI
                     VPEHFHRFEADSKEGALSGWYHDPTRVARAGEVPAVDGDGPALRAREQRSSGLPDPVPA
                     PGGAGLPNLQVESGNFFFGTARIAGDAVAGDKHVREAAADEGR"
     gene            complement(9486..10184)
                     /locus_tag="IE198_RS26430"
                     /old_locus_tag="GCM10010381_53600"
     CDS             complement(9486..10184)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544542.1"
                     /locus_tag="IE198_RS26430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53600"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_229834338.1"
                     /transl_table=11
                     /translation="METAAGSVRLEDHVPYLARLEDDSRRALMESGNELRYPARTAVLR
                     MDEPSFHVLLILDGWLKVTAAAKTGHEALLALRGPGDIVGESAALHPTTRSASVSTLEP
                     VRAVAVSADRFIGFLDAHPVAARQLMAVITERMRAGDRKRLEHASCGVRERLARLLLEL
                     AESYGEHHDHGVLVRVPLTQQELAGSVGASREAVTRLLGQLRERGVVMTSRRRLVVVRP
                     DVLRRIGGSA"
     misc_feature    10142..10156
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.52"
                     /tool="antismash"
     misc_feature    10334..10345
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.83"
                     /tool="antismash"
     gene            10369..12924
                     /locus_tag="IE198_RS26435"
                     /old_locus_tag="GCM10010381_53610"
     CDS             10369..12924
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544601.1"
                     /locus_tag="IE198_RS26435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53610"
                     /product="polysaccharide lyase family 8 super-sandwich
                     domain-containing protein"
                     /protein_id="WP_189890920.1"
                     /transl_table=11
                     /translation="MEFSRRSVLSVLPAATLLAVAQPLRAAAASRSGPAASARTAADHA
                     TLLRNTVAVFAGTAEANARPEVAPKLASIARTARSRLAAMDGAGQGELFKGVPLGTSEP
                     NLSTSFQYLYEIALATRTPGPTASDLRDDKAVQRRVIDGLVRLHAEYYGDQSKGYYGNW
                     FHWEIGISTHVSRTLVLLGDELAAYRPDLAALYVASMDGYLRGGKDGDVDLDSRFHTGA
                     NLADITTNRMLQGAVLADDARIRKAVADQLTVFARIDPYELRHGVTDGFYADGSFVQHA
                     SVAYTGSYGKGLLTRIVQTVKILDGATYVPGDDIVGVVQGWVADGFAPLIFEGWMMEIV
                     KGRAVSRTGTGYADVAAVVEAVVDICGYTAGSDAQALAGYVKYVRQTSRASLDPVSFVS
                     PVSIARYTDILNSQAPAKDLGPAASHTAFNAMDRTVHRRPGYAFALARSSDRISKYEYM
                     SGENLMPWFQGDGAHYLYLAGQDQRQAFGCDYFTAVPPYRLAGVTAPVESRRTVPELYG
                     TLWYDNPERGFTSSSESQNTYVYFPCGTDPYSGGARLGAYGAAGLVQSDDVGYAAQQAG
                     ELPDDFVAYQNARATKSWFMFDDEIVVLAAGVSGQADRAVTTTVDSRIAAPGAPVSLTG
                     RLHDRTPWHGTGTAPLAWLRYADAQQETAVGYVFLSGPRPTVALETVTRSRRVIRLANP
                     DTAVTKQVFTLSYDQGGSRPSAMAHVLVPNASERQLASYARGPLSVTANTVRLQAVRHT
                     GLGIVAANAFVPGTHHADRLAIDGPASVLLRRAADGTFSISVSDPTTRRRTVSVTIHGR
                     HLHLLSADDGVHIRRVPGGTRLEVTTHHAYGRSFTATLG"
     misc_feature    complement(13276..13290)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            13334..15307
                     /locus_tag="IE198_RS26440"
                     /old_locus_tag="GCM10010381_53620"
     CDS             13334..15307
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659768.1"
                     /locus_tag="IE198_RS26440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53620"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_229834340.1"
                     /transl_table=11
                     /translation="MAVVITVPICLLLAVAGLAVQDRAEALGDARTTRTEVGLSLRVQG
                     LVHQLQRERGLTSGLLGGEKEFRPTLAATRKRVDTALREMRRDSAVERVVRRHLGRLAA
                     IRTAADTGTADRAGTFAFYTTAVDALNAVDPVAETATGADRQLRDGLTALRELAAAKES
                     VALERGLLNGVFAEGAFQGREYLAFTEVRATRVAALARFRQVATATQLAALKHAFATED
                     AKRATAYENRAEDAADGPVPHADAGTWWDAMTVLVDDLYAVQQSVGHDARDRADRLSHD
                     AETDLAAYLVAGTLMTALVAGLAAFASRSLTRPLGALAEAAHNVARHRLPTTVARIQQS
                     PQDHAELLLAVDAPDNPDAQLLRGTAEIAEVAASLHQVEHTALRLAAEQAGLRRTTTES
                     LANLGRRNQNLVRRQLRLITRLERQELDPDALAELFELDHLATRMRRNAENLLVLAGQN
                     PPQPTAAPAGGLEVVQSAVAEVEQYRRVLIATVEPVRLRGHAVADVAHLLAELIENGLT
                     FSPPTEPVEVHGWYDTEDDTYCFAVVDHGVGMSRADKERAHARFSDSGEEALIATPTRF
                     LGHLVVGRLAHRLGEGTRVHLFDTTGGGLSALLALPGRLLAPAENPSASPPPARPAVSS
                     LLNGFRAGVAHAEARTTQGASS"
     gene            15304..15723
                     /locus_tag="IE198_RS26445"
                     /old_locus_tag="GCM10010381_53630"
     CDS             15304..15723
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006382238.1"
                     /locus_tag="IE198_RS26445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53630"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_189890878.1"
                     /transl_table=11
                     /translation="MTTAVHSFGWLISEFVRTADGVTDAVAVSSDGLLMAASDSLGRDR
                     ADHLAAIVSGITSLAQNAATAHGFHGMKLVMIEMFGGFLMVGRIRDGSCLGVLAAEGCD
                     VGLVGYEMTVLADRAGELLTPQLVRELHCAPVAAG"
     gene            complement(16716..17495)
                     /locus_tag="IE198_RS26450"
                     /old_locus_tag="GCM10010381_53640"
     CDS             complement(16716..17495)
                     /NRPS_PKS="Domain: Thioesterase (28-246). E-value: 1.2e-31.
                     Score: 102.9. Matches aSDomain:
                     nrpspksdomains_IE198_RS26450_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.5"
                     /locus_tag="IE198_RS26450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53640"
                     /product="thioesterase II family protein"
                     /protein_id="WP_189890880.1"
                     /sec_met_domain="Thioesterase (E-value: 3.6e-32, bitscore:
                     105.5, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.6e-09, bitscore:
                     31.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLLPQNAGGGSHDTLVHCPRPVADPEARVLLMHHAGGSHREYRS
                     WVQHFPTRWEVWVASRRTGAPTVGGETVTRFCHRLADALAPLGDRPLALFGHSMGALVC
                     YELAHVMRRQGLPNPVWLGVSAHSGPQQLPSGPARRPPTSEDLRAMTAELGGLQQSILG
                     NDALWALIEPALRSDIDMIATWTPEPRPRLGTPITAFCGEFDNLAGPRAVRAWEACTEG
                     FLGVRTHIGGHFYFRNAVESLIDQMVNDIRLCLRRGR"
     aSDomain        complement(16758..17411)
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS26450_Thioesterase.1"
                     /evalue="1.20E-31"
                     /label="IE198_RS26450_Thioesterase.1"
                     /locus_tag="IE198_RS26450"
                     /protein_end="246"
                     /protein_start="28"
                     /score="102.9"
                     /tool="antismash"
                     /translation="RVLLMHHAGGSHREYRSWVQHFPTRWEVWVASRRTGAPTVGGETV
                     TRFCHRLADALAPLGDRPLALFGHSMGALVCYELAHVMRRQGLPNPVWLGVSAHSGPQQ
                     LPSGPARRPPTSEDLRAMTAELGGLQQSILGNDALWALIEPALRSDIDMIATWTPEPRP
                     RLGTPITAFCGEFDNLAGPRAVRAWEACTEGFLGVRTHIGGHFYFRNAVESLIDQ"
     CDS_motif       complement(17169..17231)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS26450_0001"
                     /evalue="7.90E-07"
                     /label="NRPS-te1"
                     /locus_tag="IE198_RS26450"
                     /protein_end="109"
                     /protein_start="88"
                     /score="21.6"
                     /tool="antismash"
                     /translation="DRPLALFGHSMGALVCYELAH"
     gene            complement(17501..19096)
                     /locus_tag="IE198_RS26455"
                     /old_locus_tag="GCM10010381_53650"
     CDS             complement(17501..19096)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.5"
                     /locus_tag="IE198_RS26455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53650"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_189890882.1"
                     /transl_table=11
                     /translation="MSEQSGVVIAGAGPTGLTLGVELLLREVPVRVVDRVERPHPHSRA
                     LVLWPRSLEILDRLGVGEDIADRSIEIHGQVYYSGGRRKARINFEHLPGSRFTSPVSIP
                     QQDTERAVRDRFEQLGGKVEYGVEVVGHRTAQAGVEVVLRSEGRTWKEWTPWLIGCDGA
                     HSKVRELMDVPFPGAPYELKFVLTDGTCDTGLAHDEAHHFMTDKGVITVLGLPGGHYRV
                     VASAPAHLEVDDPVAFVQRAADERCPVPLRLVGPQKTGDFRVHRRKAERFKSGRILILG
                     DAAHINSPVGAQGLNTGIEDAHALGWRLARVQQRTLPAESLEQWAREREHMAGIVVADT
                     DRQQRMWTLTGWRAVVRDLLLGVAERVGFLDRQVPSRLAQLSNAYPSEQSGIGPVRPGM
                     RLPDAPLATGWLRDALSLHTPTLYAFAADRNKPAHLASARRLLTKARTALGPDADRLHT
                     VLVARGAPLSADRGELHDPMGAAHSSVGADRPSMVLVRPDGIIALACRFDDPRIREAVT
                     ALVRPGGGSEADGQ"
     cand_cluster    17922..28860
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    17922..28860
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[22921:23860](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      22922..23860
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    complement(19096..19109)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.45"
                     /tool="antismash"
     misc_feature    19117..19130
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.23"
                     /tool="antismash"
     misc_feature    complement(19204..19219)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    19282..19296
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.12"
                     /tool="antismash"
     misc_feature    complement(19301..19316)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            19317..19982
                     /locus_tag="IE198_RS26460"
                     /old_locus_tag="GCM10010381_53660"
     CDS             19317..19982
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018520420.1"
                     /locus_tag="IE198_RS26460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53660"
                     /product="response regulator transcription factor"
                     /protein_id="WP_229834342.1"
                     /transl_table=11
                     /translation="MNSNGTIHILVADDHVLLREALCDVLEINPDFKVVAQCGDAEQAV
                     ARSAEERPDVAVLDVEMPGNDSVATIRRMRAVSPDTRIVILTMHADHRLVQQLFREGIR
                     GFLHKSISRHALTSAIRSIHADPDRVVLSMAKEHLGLDVPPVAATLSDREVEILSLVAT
                     AMTNRQIASRLAIAEGTVKLHLHNVFRKLNAVSRIDAVNKASAASLIDWPATSRGAAR"
     gene            complement(20001..21164)
                     /locus_tag="IE198_RS26465"
                     /old_locus_tag="GCM10010381_53670"
     CDS             complement(20001..21164)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012337.5"
                     /locus_tag="IE198_RS26465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53670"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_189890884.1"
                     /sec_met_domain="t2clf (E-value: 8.9e-19, bitscore: 60.6,
                     seeds: 26, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.3e-15, bitscore:
                     49.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSAPAVRPLTITSAGVVSAAGLGLTALAEALITGKLSDAPLPD
                     PSPGEYPDLPLRPVPDPDFAGLLGRKGLRHLDRTTKLGLVACGEALHSYAADGTGNTDT
                     GVVMATSTGSVRSSAEFCRDTLVRERPYLVNAGHFPNTVMNCCSGQVAIRNQLRGVNAT
                     VAGGQLSSLFAFRYAHNALGSGRARRLLVGGVEELSPQTAWAWQHGGSLRPGTRIGEGA
                     AVFAVSAQNEECAEPADGSMVHGGPATDAAPPLGANLLACEVAYYGAPAHRGRQVQGLT
                     DVISRALHRSAVAPGDVSVVAPGAAHYTGLRHIEQRALAAALGSVPERQVRIGDFLGEL
                     YSAHGAFQLAALLALWQAEPAAERRTGLVTSLAPDGNLGCLVVRERA"
     gene            complement(21161..22384)
                     /locus_tag="IE198_RS26470"
                     /old_locus_tag="GCM10010381_53680"
     CDS             complement(21161..22384)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (84-403). E-value:
                     5.5e-55. Score: 178.9. Matches aSDomain:
                     nrpspksdomains_IE198_RS26470_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: hr-t2pks-ksa"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016435609.1"
                     /locus_tag="IE198_RS26470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53680"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_189890887.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 4.7e-41, bitscore:
                     134.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="hr-t2pks-ksa (E-value: 3.5e-97, bitscore:
                     318.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEPSDRRVVVTGLGAVSSLGIGADDFTAAIRAGRSGVSPVRSFD
                     TTGFPHVYAGEVPDFDPGSLLDHVRPDAWGRSSQLAAAAARLAVTDSALDPEELSRSAA
                     GSIMGTTSGESTVVQSLTEQWTTRGLKGLDPRLVGQLPASRIAGAVNYELSLTGDAQTI
                     PTACSASNYALGYAYDLVRSGEADFMLAGGADSVNRYTHAGFYRLGALAESVCRPFDAG
                     RSGIITAEGGVALLLETLDHAVERGARIYAEVLGYAVNCDAKHMVHPDPHSISACIRAA
                     HDSAGITSDDVDYICAHGTGTPTNDATEVAAVREVFGSAMPPISSIKSMIGHTMGAASG
                     FGALVCCKALAEGFLPPTANVELTDPALGPGVDCVPNVARPAQPKVAQNHGFAFGGNNA
                     ITIMGRVV"
     aSDomain        complement(21176..22132)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS26470_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="5.50E-55"
                     /label="IE198_RS26470_PKS_KS.1"
                     /locus_tag="IE198_RS26470"
                     /protein_end="403"
                     /protein_start="84"
                     /score="178.9"
                     /tool="antismash"
                     /translation="ARLAVTDSALDPEELSRSAAGSIMGTTSGESTVVQSLTEQWTTRG
                     LKGLDPRLVGQLPASRIAGAVNYELSLTGDAQTIPTACSASNYALGYAYDLVRSGEADF
                     MLAGGADSVNRYTHAGFYRLGALAESVCRPFDAGRSGIITAEGGVALLLETLDHAVERG
                     ARIYAEVLGYAVNCDAKHMVHPDPHSISACIRAAHDSAGITSDDVDYICAHGTGTPTND
                     ATEVAAVREVFGSAMPPISSIKSMIGHTMGAASGFGALVCCKALAEGFLPPTANVELTD
                     PALGPGVDCVPNVARPAQPKVAQNHGFAFGGNNAITIM"
     gene            complement(22377..22658)
                     /locus_tag="IE198_RS26475"
                     /old_locus_tag="GCM10010381_53690"
     CDS             complement(22377..22658)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (16-70). E-value: 2.1e-13.
                     Score: 42.4. Matches aSDomain:
                     nrpspksdomains_IE198_RS26475_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.5"
                     /locus_tag="IE198_RS26475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53690"
                     /product="acyl carrier protein"
                     /protein_id="WP_189890889.1"
                     /sec_met_domain="PP-binding (E-value: 5.3e-13, bitscore:
                     42.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQNGMAVTNPSKQLELIRSIVAEELELESSEVDDSTSFVDGYAA
                     DSLSLIQVFARIERELHVSVPQEEMNNMVDIRATQAIVARYAGEPIDA"
     aSDomain        complement(22449..22610)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS26475_PP-binding.1"
                     /evalue="2.10E-13"
                     /label="IE198_RS26475_PP-binding.1"
                     /locus_tag="IE198_RS26475"
                     /protein_end="70"
                     /protein_start="16"
                     /score="42.4"
                     /tool="antismash"
                     /translation="LIRSIVAEELELESSEVDDSTSFVDGYAADSLSLIQVFARIEREL
                     HVSVPQEEM"
     misc_feature    22807..22822
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     gene            22922..23860
                     /locus_tag="IE198_RS26480"
                     /old_locus_tag="GCM10010381_53700"
     CDS             22922..23860
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041195.1"
                     /locus_tag="IE198_RS26480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53700"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_268246501.1"
                     /sec_met_domain="AfsA (E-value: 2.4e-22, bitscore: 72.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERALVHRAAVAEVFVTDMRKVGEDRYLAGAQLPLSHAYYSDHRQ
                     TPRLFDPLLLLEASRQAAVYGAHTHLGIPLSTSFLVNSLSVVFNDATALRMGGHPGELH
                     LATSYPAVRRRGDEFRAVGVSQDLYLDGRPSGRVTMSVSSMSPKQYRALRYLQRDSEPP
                     TTERAPLTAGVAAAAAAVARESALNVVVSRPVPEGEEVRAALVPRYDNRSLFDHTYDHV
                     PAMVLAEGARQLALLAVADTGVPVERTWISDCSARFLRFAELDQPVLLSAPRRPAAEAG
                     FHQVPVRLRHHDTEIAEISVTVATLPEEGMS"
     gene            23857..24549
                     /locus_tag="IE198_RS26485"
                     /old_locus_tag="GCM10010381_53710"
     CDS             23857..24549
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266167.1"
                     /locus_tag="IE198_RS26485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53710"
                     /product="HAD family phosphatase"
                     /protein_id="WP_189890893.1"
                     /sec_met_domain="HAD_2 (E-value: 4e-08, bitscore: 26.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVRAVWSDFGGVLTPPLDVTMADFCRRVHVPPAVLRQAMHRVA
                     EGYGTDVMAPLDTPLVSEDEWCRQVEAVLHEEHGIAADLTGFAEKWFTNRDTNEPWLAT
                     LRELRERGVFVGLLSNMVPSWDWYWRRMVPPTLFAGIVLSFEVGRRKPEPGIYDYAALT
                     AGVAPDECVLVDDLADNCSGARAAGWKAVHFTDTVSAARELEELLTVPGSVPVSPVPAT
                     SVPVISDR"
     gene            24555..25256
                     /locus_tag="IE198_RS26490"
                     /old_locus_tag="GCM10010381_53720"
     CDS             24555..25256
                     /NRPS_PKS="Domain: PKS_KR (2-156). E-value: 1.3e-22. Score:
                     72.5. Matches aSDomain:
                     nrpspksdomains_IE198_RS26490_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385006.1"
                     /locus_tag="IE198_RS26490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53720"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_189890895.1"
                     /sec_met_domain="adh_short (E-value: 5.8e-35, bitscore:
                     114.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSVLVTGGNRGIGLAIARSLAARGDRVAVTHRSGEPPEGLLGVR
                     CDVTDEKSVEEAFARVEEVQGPVDIAVANAGITNDGLALAMSDEDFGRVINTNLMGAFR
                     VARRAAARMATARWGRLLFVASTVGMAGSPGQANYAASKSALIGLARSMAWELGRRNVT
                     VNVLAPGLIETDMITHVSDKRRAELIRETALRRVGTAEEVARVADFLTSDASSFMTGAV
                     IPVGGGHGMGH"
     CDS_motif       24561..24644
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS26490_0001"
                     /evalue="2.20E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE198_RS26490"
                     /protein_end="30"
                     /protein_start="2"
                     /score="26.7"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAIARSLAARGDRVAV"
     aSDomain        24561..25022
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS26490_PKS_KR.1"
                     /evalue="1.30E-22"
                     /label="IE198_RS26490_PKS_KR.1"
                     /locus_tag="IE198_RS26490"
                     /protein_end="156"
                     /protein_start="2"
                     /score="72.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAIARSLAARGDRVAVTHRSGEPPEGLLGVRCD
                     VTDEKSVEEAFARVEEVQGPVDIAVANAGITNDGLALAMSDEDFGRVINTNLMGAFRVA
                     RRAAARMATARWGRLLFVASTVGMAGSPGQANYAASKSALIGLARSMAWE"
     gene            complement(25328..26914)
                     /locus_tag="IE198_RS26495"
                     /old_locus_tag="GCM10010381_53730"
     CDS             complement(25328..26914)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="IE198_RS26495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53730"
                     /product="MFS transporter"
                     /protein_id="WP_189890897.1"
                     /transl_table=11
                     /translation="MSTLPNAVTAPPRRGLILLAVCLAVLMVPVSLSGTSVALPAISRS
                     LHADIGPLQWAVNGYNVTAASFMLAAGSLADIVGRRRMFALGAGLFGASSLACALAQNI
                     YLLDVARALAGVGSASLITAGTAIIATAFDGEARNRAFAVTGVVIGAGLAIGPTSSGWI
                     ISLSGWRGIFLSQLFIAVVVLAMLRFMPESRDPEAKSVDWVGTGTFTSALFVLTVAVAE
                     GARIGWTSPAMVGLLVVFLVLIGAFVGAERRHARPMFDVSLFRQSRFVALCMLPVIFSF
                     GFVGFVVLMPSYLIGANGRSSGEAGLAMLLLTGPVLVVPLLASKFLQWGMSSRILLTLS
                     LLVTTAGVAWLTVIEPGMGWGALIGPMVTIGVGQGLSSGLMDGAAISSVPPARAGMAAG
                     MFNTMRLAGEAVAIAAMGGVLVTLIRDSLSGGFAKFQAQTDSSVNGLADSVASGNAADA
                     ADSVSAADRATFIDFLAQGHTDAMHLMLWSVAALCAVATVAAWFLLAERPAPGEATAEK
                     PTAEQREQVTS"
     gene            complement(27057..28358)
                     /locus_tag="IE198_RS26500"
                     /old_locus_tag="GCM10010381_53740"
     CDS             complement(27057..28358)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS26500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_53740"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_189890899.1"
                     /transl_table=11
                     /translation="MSIEETNPAVAQPARPGRETVEVVAGARAAGPEDVQHVKVLKVGP
                     ADAPRVLVMLGGREGAAAGFLTLARELVSAVPGLEVWAIDRREQNLADLTHYADQANQD
                     SYYLDGRYVRQDGASAPFAASWGLGVLLEDVRSVVLKARDGGRRQVVLGGHSVGGAAVA
                     HYAAWDFDGQPGHADLAGLMQFDGGVRDAFKGAGMEFALNVDAAKAWLGQIEQGAVFEN
                     ATSLAVRVGEQPEDAALWYHLAARHALNDPHGPAVLQPKLPAGYATDGPLTNAGLFGKL
                     VCTEVGHPGYAVQSGRLDAAGDWADEGPTPLLRVAEAHAGRPSGAFVWYALNRVMLDYV
                     AGNDFTDNEVTRLLGLRLFHTADIDVPLYAFGSGLTNGTVASAAEELGTSTKIPYVRAH
                     TDVELTHQDLVYAAAEHNTALSTAVAFLKELFAG"
     misc_feature    complement(28553..28567)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.33"
                     /tool="antismash"
     misc_feature    28556..28572
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.75"
                     /tool="antismash"
     gene            complement(28762..29148)
                     /locus_tag="IE198_RS26505"
                     /old_locus_tag="GCM10010381_53750"
     CDS             complement(28762..29148)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024852.5"
                     /locus_tag="IE198_RS26505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_53750"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_308426859.1"
                     /transl_table=11
                     /translation="MRSTGGKSHAGPGGQRPSCRTAKNITGEAVQGDLIAGVPPLAAAF
                     AGSEAVVNAAGVSDLTSPELLAVDRDGVIAAVRAAQTADVRRFVRVSAMPADRAEQAPP
                     PYRGVRPGGLHDRPGKGRIRVGRR"
     misc_feature    29119..29132
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
ORIGIN
        1 ttgcccttgt ccttgcccct gcccttgttt ttgtcctgct tcgtcttctc ttccttctcg
       61 gccgccgatc cgcccgcgtt cttcaccggg tccgaccccg cccccgccga acagccggtc
      121 accactccca tgacgagcgc tgcccgcacc gctccgagag ccgcgccccg cacccgtccc
      181 cgcaacacac cgcgcaccga aggttccccg ctctgtccat ggagccgcca ccgccgtcgg
      241 cggcacagca ggatcgatcc taggcagcgg acgtcgagga aggaccgatc gatgggtgag
      301 aacaaggacc ggatgctggc gggcgagtgg tacctccccg acgacgagga gctgggcgcg
      361 gacacccgcc gccgcttcga actctgcgcc gcctacaacg cctacggtgg cgccgacccg
      421 gcagggcgcg gggcgatact cgccgaactg atcggctcgc tcggcaagga cgtccgcatc
      481 cggccgccgt tccagtgcga ctacgggcgc tgcatcacca tcggcgaccg tacgttcatc
      541 aactaccaag cggtcttcct ggacgccgct cccatcacca tcggctccga cgtgcagaca
      601 gggccagggg tgcaactcct caccccaccc acgacatgga cgcggagcgc cgtcgcgcgg
      661 gctgggagaa ggcggccccg atcacgatcg gcgacaacgt ctggctcggc ggcggcgtga
      721 tcgtctgccc cggggtcacc atcggcgaca acacggtcgt gggcgccggg tcggtggtcg
      781 tcagggacct gccggccggg gtgctcgccg tcggcaaccc ggcccgtgtc gtacgcagcc
      841 tcaccgggtg atgaccagct tcccgcgcgc atgaccggtc gcgttcgacc cctgggccgt
      901 ggcagcgctc ggcgagcgga cacgtccggc ggtccggctg ccggagcgcc ggagccggtc
      961 cggcgacgac gacgaggcgt ggtcgccggc cccgacggcc acggcgttgt cggaccctgc
     1021 tgccacactc gaacccatgg gcggacggtg ggctctggcg gcggccgaag gaggaggagc
     1081 gcggctcgtc cccctcggcc ccgacggcct gccctcgggg ccggtcctcg aggagcccga
     1141 cctggtcgag gcggtccggt cccggcccga ggtcggccgg tgggtgtggc ggtccactgc
     1201 ggagatctac ccccggctgc tggctgccgg agtccgcgtc gagcggtgct acgacatcga
     1261 ggacgccgag ctcctgctgc tcggccacga ggggcggctc ggcgagccac gctcggcggc
     1321 ggccgcgtgg gcgcggctgc acaacgctcc cgtgccgccc gacccgcccg cccgtgcggc
     1381 cgagcccggc tcccagtcct ccctgttcga gccgcagccg gtcacggtgc cgctggaggc
     1441 gctgctcgag gtctacgccg agcagcagcg aaggcatgcg gcggccgagc accccggccg
     1501 tatgcgcctg ctgacggccg ccgagtccgc gggcatgctc gtggccgcgg agatgagccg
     1561 cgcgggactc ccgtggcgcg ccgatgtgca ccgcgaagtg ctgcacgagc tgctcggcga
     1621 gcggtacgcg ggcggtggcg agccgcggcg cctggcggag ctgacggaag aggtgtcggc
     1681 ggccttcggc cgacgggtgc ggcccgacct gccggcggac gtcgtcaagg cgttcgcccg
     1741 ggccggtgtc aagttgcgct cgacgcggca ctgggaactg gcggagatcg accacccggc
     1801 cgtcgaacca ctgatccgtt acaagaagct gtaccgcatc tggaccgcgc acggctgggg
     1861 ctggctgcag gactgggtgc gggacggccg gttccggccc gagtacctgc cgggcggtac
     1921 ggtctccggc cgctggacga ccaacggagg cggggcactt cagatcccca aggtgatcag
     1981 gcgtgccgtt gtcgcggacg aaggctggcg tctcgtcgtg gccgacgccg atcagatgga
     2041 gccccgggtg ctcgccgcga tctcgcggga ccggggcctg atggaggtcg cgggtcacga
     2101 cggcgatctc tacaccgccc tgtcggaccg cgccttctcc ggcgaccgcg cccatgccaa
     2161 gctggcgctg ctcggtgccg tctacggcca gacgtcgggc gacggcctga agaacctcgc
     2221 tgcgctgcgc cgcagattcc cccgcgcggt ggcctatgtg gacgacgcgg ccaaggcagg
     2281 cgaggaaggc cgactcgtac ggacctggct ggggcgaacc agcccccggg ccatcggggc
     2341 gggcgacgac gacgaggcgg gcattccgca ggagactctt gaaacgaccc ctgccgagga
     2401 cgggttcaca cccggttacg cctcggcgaa cgcgcgggcc cggggccgtt tcacccggaa
     2461 cttcgtggtg cagggaagcg ccgccgactg ggcactggtg atgctggctg cgctgcgtcg
     2521 ggccacctcg gcaatgcggg cggagctggt gttcttccag cacgacgagg tgatcgtgca
     2581 ctgccctgcc gaggaggccg aggacgtggc ggaggcgatc cgctcggccg gtgagctggc
     2641 cgggcggatc gccttcgggg agacgccggt gcggttcccc ttcacgatcg cggtggtgga
     2701 gcgctactcg gacgcgaaat gagccgcgcc cggcagggcc cttcggcctc atccggccgc
     2761 tgtgcgccac ttctcgtcga gcacgacggt cctcatctgc tcgatgctca gcaccggctc
     2821 ggcgcggctg gcgtccttgc cctggccggg tgcgttgaag gccgtcatca cgacccggaa
     2881 gccgtcggga cgcagggtgt ccaccgtcca tccgacaacc cccgcgccgc ccttctggtc
     2941 ggggtcgttc tccttcttca ccatgacctt ggtgccgtcg ggcagcgtgg tcacgtcacc
     3001 ggcgaagacg tcctgcgcca gatccgccat accggtctgg gcgttgacct ggatgaagct
     3061 cgcgccccgg ccgtcgtcgg cgacgacgaa cccgtagccg gggtcgccct gctggtcgac
     3121 gatctccagg ttccccggaa gcagggaggc gaggaccttg ttcaccgcag cgccgtcggg
     3181 ccggcccggc gggggcgtct cctcgcgggg cttgccgagc tgcgcgccga tcgtccgcca
     3241 cacctcgttg gtgaccagcg ccttcatctg cgtcgccatg agtggcggcg tcggccggct
     3301 gacctgtgcg cccttctccg cgcgcgcgtt ccactcgctc gcgtcgacct tcacaccctt
     3361 gggcgtgacc agggtggcac gccacacttt ggtgtcctcg cgacggtccg ggtactcgta
     3421 gccctggaag agcatgtagc gggagccgtc ggacagcgtc tcctcctggc atgcgtcgtg
     3481 cggcatcagc gcctgcgacg ggcaggtcac ggagtccgcg gcgccctgcc cggtggggtc
     3541 gacgacgctc acaccgaggc ccatggccgc cgcgcccctg ccgtcgtcga acaccaggtg
     3601 gacgtaaggg ccgtgcagtc cgccctcggg gtccttggtg ataccactgc cgtcctcgcg
     3661 gatggtcctc ccctcgggca gcagcccctt gaaggtctcg atcatctctt tgagggtgac
     3721 accgccggcc tccgccggag ccgaagccga atccgaggcc ggggcagtcg gcccggccga
     3781 cgccgcggcc gacgaccgac cgccgtccga accgagggcg ccggtcgtgt acccgccggt
     3841 caccccgacc acagtcagcg caaggacact gccggtcacg gcgaccgccc gccgccgggc
     3901 cagccggcgg cgcccacgga tcaggccgcc gtccaccagc cccggccggt cggaggggcc
     3961 aaaggtctcc ccggtgcggc gcatcgccgc accgagatcg tcctcgaaag gcatggggaa
     4021 ccacactctc tggtcgcaac atacggaatg aagtgttcga gcccgccccg gggctgctgt
     4081 gcgggcgcta acgagcggcg aactcgacca ggctgccgcc cagttgttcg cgcagcttcg
     4141 cgagcgcccg caccgctctg gtgcgcacgg cggcagagct gacgttcatg gcgtcggcgg
     4201 tctcctcgat gctgcggtcc tcccagtacc gcagtacgac gaccgcccgg tccttcggcg
     4261 agagccggcc gagcgctccg aggagagcca ggcgcaactc ggggtcgtcg ccggagagca
     4321 gggcgcagtc gggcagttcg ccgaccgggc gttccgaggc ggagcgacgg cgccggtagg
     4381 tgaggaacga gcggacgagc acggtctggg cgtatcccgc cggattgtct atccgggaga
     4441 cacggcccca caacatgtac atccggccga gcgtctcctg caccaggtcc tccgcgaggt
     4501 gggtgtcccc gctggtcagg aggcaggcgg agcggtagag gtgcgcggcg cggttcgccg
     4561 cgaactctct gtactcctca gtgcgggacg ctctcatccc ctgctcactc tcccccgtgg
     4621 gtgccgacga ccccttcacc tcaatgacgc gacgacgtcc ccgtaatgtt tcaacctgct
     4681 tccgggaccg gtccgaccgg cggtacgcgt ccggggcggg tgcctgcgcc gggcggctac
     4741 ccgtccggtg gcacctcgtg agtgaaccgc ctgccctcgc actcctcgcg caccgaggcg
     4801 accgagtgtc gaatccagcc ccagctccct ccggctcccg ccaccgctgc cggtcattgc
     4861 cactgcgtcc cggagagcac cacgaccgct gcggcgaccg tcccgacgcc cagtgatccg
     4921 cggtgcccca gccgtgcggc accctcgtac agtgcggaga gcacggctcc cgcgcaccgg
     4981 tggccaccgc cggccagcgc gcacaccgcg tccccgtagg tgtaggcgaa aggcgcggcg
     5041 tgacccgata tccgccgctg gacgcgggtg aaccagtact cgggcatgag caggccgacc
     5101 acgacgacgt tgagcgcgta ctcgacgccc acaccgagat gggccagcaa cggcgccgtc
     5161 gcccagcgca ggaagacgta gaaggctccg ctgagagcgg cgaaggcggc caccgaccac
     5221 atcacctcgg aaggctcggt catcccggct ccccttgccc gtccccgccc ttctcggcgt
     5281 cctgacggga gtgaccggcc tcgagctgct cgcggtagag cggctgctta cgcgtccggc
     5341 cctgtgccgc gtcggccaac cgcgccttga ggctttccag cgccacgcgg gcgggctcct
     5401 ccagcatgtg gtcctcgagc actccggcat cgaggagctt ctcgatgatg tgcacctggt
     5461 tggcgctcgc ctcgcgctcg tcgtcgcgga ttccctcgat ggcgagagga atgtccctcg
     5521 ggttctcggc caggtgcagt ccccagcgct cgacgtcgcc ctgcgccagc atctgggcgt
     5581 agaaccgggt ccgctcgtcc atgagctgct gttcgttctg ggtccgcagc cgggtcagct
     5641 cgtgctcgct cgtcgtcgtg gccctcgcgt agtcgatgct gcgcagggac gagtactgac
     5701 gtaccgcctc ttcgtcgagg ctcagtcgga tctggcagtg gatctccagc ccttcggccg
     5761 cggcaagggg caccgccgcc agggcgtcca tcacagccgc ttcggcggcc gcactgcgct
     5821 cgatcgcgaa acggcgggtc tcttgacgca tccgtgccag cagccgaggt tagatcagcg
     5881 cgcgcacgtc acgcacacgc ttctccacga cggcggtggg gtcgacgacc ctccaggtca
     5941 ggtccgtctc cgccgagaag aagaaggcgt cgccgtcgct gggcagccgg tgatcgaagg
     6001 agagatgctg tatgcccatc tcgacctcgt acagggtgcg gaagttcttg ctcaccagtt
     6061 cgccgcgcgt cggctgctgg tgcggcaggt acgtctgcgg tctgccgccg gacgtgagga
     6121 acaccagggc ccgttcggcg aaggcggggg gccggtgccg tacgaattcg aagcggtgca
     6181 gtgtccgcac attgcgtacg ggatcgttca tgaccgccgg gtggaccggg tgcgccaccg
     6241 gggcctcggg cacctggtcc gctccgggga atcgctgttc catctctgct cttctctgtg
     6301 tgtgctcatc ggtgaggcgc ggtcagcgcg acggcgccga tacggagggg agccgggctc
     6361 gcaggtgttc cgccgctccg ttcgacgagt cctcgtcacg gatcttgcgc agcaggtggt
     6421 cgagccggtc ccggtcgttc gcggtggtca ccaggtccgg cagcagccgt gcgacggcgg
     6481 cctccacagc cggttcccgg gcggcccgca cccatgaagc gagcaccgtc agtgcgtcgc
     6541 ggcgcagttc acggtcgtcc agcacgtgcc gccacagggc ggtgacctgc tctccgacca
     6601 cgggatcctg gtccgccgac cacagcagcc gcggaccggt gcaccccgcc gccggctggt
     6661 acgtgtgccg tccggccgcc cggaggaatc cctcacccgc cagctgccgc aggttgcccg
     6721 gcgactgccc ccactgcttc agcgcggcaa ggctctcctt ctgtgccggt ccatgcagca
     6781 gcgtctccac ggtctgcacg agagcggacc acagggcctg gtcgggggtg gttccggtcg
     6841 acgccatccg ggcgatctcc cgcagggctg tcgaggcgga cgcgtccccg agcagcgcgt
     6901 aggtcctcac cacggtccat ctgcgtccct ggctgccctg tcggctccag tcgctcagca
     6961 agcgccggac gaccatgtcc atccccctgg cggccgctgt gtagagggac catgcggcca
     7021 actgccgctc catcaaccgg tccgaggagg cccagggagc gatgaggcgg tcgaaggcgt
     7081 acccgaagtc ggcgcacgcc agcactccgg cgaccaccgc accccgcagt cgcaccaggg
     7141 ccctgctgtc ggaggcgagc gtgtccagcc actcgagcat cgggagccgg gcggcgggat
     7201 gactcatcca cacgtgctcg aggacagcgg cccaggcacc gctgttctcg aaggcgacga
     7261 ccctttccgg gagcgtgccc cacggagtgt ccgtcttccg gtcgcgttca tgcgccctcg
     7321 ccagggcgag acgtgcgctc cgggacgtac cgaacaccgg gtgcccgccg ggtccgtccg
     7381 gtccctcgac cgactgcatg ctccggaaga gagcgtcccc gaattcggcg acgaggggat
     7441 agggcgatcc gtcgaaggcg gcgagcgaga tcagaaacgc cttgtcacgc aggtccggcc
     7501 ccgtcgagga gaaccatgtg tcggcgagtg cttcggccga ggaacgtccg tacaccgcga
     7561 gtgcgtcggt accggcccgg ccgtcggcgt gcgcggccag caaccgggcg aagtcggcgg
     7621 cctctcccgg cgtggggcgt tcccgtaagt agttccgggt ctcctcgaga tcaagcagac
     7681 gggcgcactc ctcactcacc cggtcctgtg ccgaccgggc aacgggcccg gtgtcgtgcg
     7741 agtgcgaggg gcccgtcgac cgggccgcca gacggaccgt caggtgtgcc cggaccacat
     7801 cggccgcggg aggtggcgtc cagtccaccg tcaccgcccc gtccaccacc gtgtcggggg
     7861 acgtgactgc tatgaacaag ccgccggagt cggcgattcg catgcggacc gcgtgcatgt
     7921 gcacgtcgcg cagggggcgg tccccaccgg tgggcggatc cacgacgagg tgggccgctc
     7981 cgggtcggat gtggtcggcg aactcggccg gttcggtgcc cgggtccagg gcgatcacct
     8041 cgctgccgcg cttgcgggcg tggatcagca tccgcagggc ggcggtccgg cgaccggtcc
     8101 cctgccgacc gcgtaacacc agcacccgtg cgtccgacag cttggcgcag gcctcgtcgt
     8161 atctgcgcgt cggcgcgaac gtcgtttcca ggcggttcag ttcctcggcg ggcacggggc
     8221 cgaccggacg cagtcgtgac cggccttcgc cggtgtgcac gtgcacgtgt ttgtcgccgc
     8281 cgacgacatc accgtcgacc tgggtgtcgc cgaggacgtt ggcccgctcc gcccgcaggt
     8341 ggggcgccag ggtgaagagt tgctccaccg cctcccacgc ctcgggcacg acgtcggtgc
     8401 cgcgggcctc gcctccctcg tcctccgcct cctggggtgt gctccggtcc tccggttcgc
     8461 gagccccctt cgcgtcctgc tccacgtttc ctctcacgtt ctctttcacg tcatcggccc
     8521 tcatcggccg ccgcctccct cacatgcttg tcaccggcca ccgcgtcccc ggcgatccgc
     8581 gccgttccga aaaagaagtt gccggactcc acctggaggt tcggcagacc ggcgccgccc
     8641 ggcgccggta cgggatccgg caggcccgac gaccgctgct cccgggcccg cagggccggg
     8701 ccgtccccgt cgacggccgg cacttccccg gcccgggcga cccgcgtcgg atcgtggtac
     8761 cagccggaaa gggcgccttc cttgctgtcg gcctcgaagc ggtggaagtg ctcgggaacg
     8821 atcccgtgat gtccgtgccg taccaccccg tggtgcaccg gatccgacac gcacagcaca
     8881 ctcggttcgg tcgtggccgc gagcgcgtcc ttcagtcctt tcgagtcgag cagccggaag
     8941 gcgagcacca catcggcgcc gacagcgccg tactcgtcca gcgcgacctc gcccgtgtgc
     9001 acgacgagtc gcagccgcac ctgtgaaccc gccgccgcga gacggttgtt gctgcgcagc
     9061 cgcatggggg tcgtcgtcag cagtgccctg atcagtgccg gcttgggaac accgggatcg
     9121 atgagcacga acactccgtc gccccggtcc tccgaccggt actcggtcgc ctccacgaag
     9181 gccgccgaca aggtctctcg caggaccgcg tacagcatgc gccggatgac ggcctgttcg
     9241 acatcggtcc tgctccctga accttcgatg tccatcagca ggatggtcct gttgctgggt
     9301 tccgtcatgg cgcttcccct tggatgtgtc gtcgtggcac ggcgggcatt gcacggctct
     9361 gccgtgcggc tgcctgctgg ttcgatgcgg cctctgccgg tccggtgcgg cctctgccgg
     9421 ttcccgagaa ttccgtatcg gcaccgttca ggggaggacc gttgccacag ccggagtgtg
     9481 accgattacg cagaaccgcc gatccgccgg agcacgtccg ggcggaccac gaccaggcgc
     9541 ctgcggctcg tcatcaccac tcctcgctca cgcagttggc cgagcagccg ggtgaccgcc
     9601 tcccgcgagg cgcccacgga gccggcgagt tcctgctgcg tgagcggtac gcgcacgagg
     9661 acgccgtggt cgtggtgttc gccgtacgac tccgcgagtt cgagcagcag tcgggcgagc
     9721 cgctcccgca ccccgcagga ggcgtgctcg agccgcttgc ggtcgccggc ccgcatccgc
     9781 tccgtgatca cggccatcaa ctgccgcgcc gccaccggat gggcgtccag gaacccgatg
     9841 aaacggtccg cggatacggc caccgcccgc accggttcca gggtggacac cgacgcggag
     9901 cgggtcgttg ggtggagagc ggcactctca cccacgatgt ctccgggccc ccgcagcgcc
     9961 agaagtgcct cgtggccggt cttggcggcg gctgtcacct tcagccagcc gtcgagaatc
    10021 agaaggacgt ggaaggaggg ttcgtccatg cggagaacgg cggtgcgggc gggataacgc
    10081 agttcgttcc ccgactccat gagggcacgg cggctgtcgt cctccagacg tgccaagtag
    10141 gggacgtgat cttccagccg gaccgatccg gcagctgtct ccacagcgac gtccttcccc
    10201 cggacacccc tcgcgttcct ggcgagcggg ccactcagcg cccgtcgatt gttgctcacc
    10261 gcgacggagc gggcaacgaa ttccgaccgg ggcagggacg ttgacacgcc ggagcaccgt
    10321 tgcttggctg acagcaagcg ctttctggcc gaaccttgga gcgttccggt ggagttctcg
    10381 cgtcgttcgg tgctgtccgt gctccccgcg gcgacactgc ttgccgtggc acagcccctg
    10441 cgagccgcgg ccgcatcccg gtccggtccc gcggcttccg cgcggaccgc tgccgaccat
    10501 gccaccctgc tccgcaacac ggtcgccgtc ttcgccggca ccgccgaggc gaacgcccgc
    10561 cccgaggtcg ccccgaagct cgcgtccatc gcccgaacgg cccggtcccg gctcgccgcg
    10621 atggacggcg ccgggcaggg tgagctcttc aagggtgtcc cgctcggcac gagcgagccc
    10681 aacctgagca cgtcgttcca gtatctgtac gagatcgccc tcgccacccg tacccccggc
    10741 cccaccgcct cggacctgcg cgacgacaag gcggtccagc ggcgggtcat cgacggcctg
    10801 gtgcgcctgc acgccgagta ctacggcgac cagtcgaagg gctactacgg caactggttc
    10861 cactgggaga tcggcatctc cacccacgtg tccaggaccc ttgtgctcct tggggacgaa
    10921 ctcgcggcgt accggcccga cctcgccgcg ctctacgtcg cctccatgga cggttacctc
    10981 cgaggtggca aggacggcga cgtcgacctc gactcgcgct tccacaccgg cgccaacctc
    11041 gccgacatca cgaccaaccg gatgctccag ggggccgtcc tcgctgacga cgcccggatc
    11101 aggaaggccg tcgccgacca gctcaccgtc ttcgcgcgga tcgacccgta cgagctgcgg
    11161 cacggcgtca ccgacggctt ctacgcggac ggttcgttcg tccagcacgc ttccgtcgcg
    11221 tacaccggct cgtacggcaa gggcctgctc acccggatcg tgcagaccgt caagatcctc
    11281 gacggcgcga cctacgtgcc cggcgacgac atcgtcggcg tcgtgcaggg ctgggtggcc
    11341 gacggcttcg ccccgctgat cttcgagggc tggatgatgg agatcgtcaa gggccgtgcg
    11401 gtttcccgga ccggcaccgg ttacgcggac gtcgccgccg tggtggaagc cgtcgtcgac
    11461 atctgcgggt acaccgccgg cagcgacgcc caggccctcg ccggttatgt gaagtacgtc
    11521 cgccagacct cacgggcgag cctcgacccg gtctccttcg tctcccccgt cagcatcgcc
    11581 cgctacaccg acatcctgaa ctctcaggca cccgcgaagg acctcgggcc cgccgcctcc
    11641 cacaccgcgt tcaacgcgat ggacagaacc gtccaccggc ggcccggcta cgccttcgcg
    11701 ctggcccgca gttcggaccg gatcagcaag tacgagtaca tgagcggcga gaacctgatg
    11761 ccctggttcc agggcgacgg cgcccactac ctctatctcg ccggtcagga ccagcgacag
    11821 gccttcggct gcgactactt caccgccgta ccgccgtacc gcctggccgg cgtcaccgcc
    11881 ccggtggaga gccgccggac ggtcccggag ctctacggca cgctctggta cgacaacccc
    11941 gagcgcggtt tcacctcgtc ctccgagtcg cagaacacct acgtctactt cccctgcggc
    12001 accgacccgt actccggcgg cgcccgcctc ggtgcgtacg gagcggccgg actcgtccag
    12061 tccgacgacg tcggctacgc ggcacagcag gccggcgaac tgcccgacga cttcgtcgcg
    12121 taccaaaacg cccgcgcgac caagtcctgg ttcatgttcg acgacgagat cgtcgtcctc
    12181 gccgcaggcg tgtccggtca ggcggaccgg gcggtgacca ccactgtcga cagccgcatc
    12241 gccgcgcccg gcgcccccgt ctccctcacc ggccgcctcc acgaccggac gccctggcac
    12301 ggcacgggca ccgccccgct ggcctggctt cgctacgcgg acgcgcaaca ggagaccgcg
    12361 gtcgggtacg tcttcctgtc cggcccccgg ccgaccgtcg cgctcgaaac ggtcacccgc
    12421 agccgccgcg tcatccgcct ggccaatccc gacaccgcgg tcaccaaaca ggtcttcacg
    12481 ctctcctacg accagggcgg ctcacggccc tcggccatgg cccacgtcct cgtcccgaac
    12541 gcctccgagc ggcagttggc gtcgtacgcc cgcggcccac tctccgtgac ggccaacacc
    12601 gtccgtctcc aggcggtcag gcacacaggc ctgggcatcg tcgccgccaa cgcgttcgtc
    12661 cccggaaccc accacgcgga ccgcctcgcg atcgacggcc cggcgtccgt gctgctccgc
    12721 cgtgcagccg acggcacctt ctcgatctcg gtttccgacc cgacgacaag gcgccgcacc
    12781 gtctcggtca ccatccacgg ccgccacctg cacctcctct cggccgacga cggcgtccac
    12841 atccgccgcg tcccaggcgg cacccgactc gaggtcacca cccaccacgc ctacggccgc
    12901 agcttcacgg cgacgctggg ataggggcgg cctgccgaga cggccggcgg cgcgcgggcg
    12961 gttaacgggg gcgtcgggcc ggcggccggt ggcgcgcgtg cgtccgaacg gggccgtatc
    13021 gggccggcgc tccgcgagcg cccaccgtgg gagcggcgcc caaggggcct gggctcccag
    13081 cctcctggcc cgcggcgtga gggtggcgca accgaacttc ccacgttgcc taacagccgg
    13141 gaaaccgccc ggtacggcga ttggactagc ttcgtgacgt atgagggcgt gggagccggt
    13201 acgtcagctg ctcggcaggc ttggcgcaat cggcagggac aggtcggaca agggcgtttc
    13261 agcgcgccgt cacggtggcc gaacggctcc cggtcgtcgg cctgtgaccg gctggcgcag
    13321 tatccggggc cgggtggcgg tggtcatcac cgtcccgatc tgcctgctgc ttgcggtggc
    13381 cggtctcgcc gtgcaggacc gcgccgaggc cctcggtgac gcccggacga cccgtaccga
    13441 ggtcggcctc agcctgcgag tccagggcct cgtgcaccag ctgcaacgcg aacgcggtct
    13501 gaccagcggc ctgttgggcg gcgagaagga gttccgccca acgctggccg ctacgcgcaa
    13561 gcgcgtcgac acggccctgc gtgaaatgcg ccgtgacagc gccgtcgagc gtgtcgtccg
    13621 acgccacttg gggcgcctcg ccgccatccg caccgctgcc gacacgggca ccgccgacag
    13681 ggccggcacc ttcgccttct acaccacggc cgtcgacgcc ctcaacgccg tcgaccccgt
    13741 ggcggagacc gcaaccggtg ccgaccggca actgcgcgac ggtctcacgg cgttgaggga
    13801 gctggctgcg gccaaggaat ccgtcgctct cgaacgcgga cttctcaacg gcgtgttcgc
    13861 cgaaggcgcc ttccagggcc gcgagtacct cgccttcacc gaggtgcgcg ccacgcgcgt
    13921 cgccgccctg gcccgcttcc ggcaggtggc caccgcaacc cagctcgcgg ctctgaagca
    13981 cgccttcgca accgaggacg ccaaacgcgc caccgcgtac gagaatcggg cggaggacgc
    14041 cgccgacggc cccgtaccgc atgccgacgc cggcacctgg tgggacgcga tgaccgtact
    14101 cgtcgacgat ctgtacgccg tgcagcagtc ggtcggtcac gatgcgcggg atcgggccga
    14161 ccggctcagc cacgacgccg agacggacct cgccgcctac ctcgtcgcgg gaacgctcat
    14221 gaccgcgctc gtcgcgggcc tcgccgcttt cgcctcccgt tccctcacgc gcccgctcgg
    14281 cgcgctcgcc gaggccgccc acaacgtggc gcggcaccgg ctgcccacga ccgtcgcccg
    14341 tatccagcag tccccacagg accatgcgga gctcctcctg gcggtggacg ccccggacaa
    14401 ccccgatgcg cagttgttgc gcggcacggc ggagatcgcc gaggtcgcag cttccctgca
    14461 ccaggtggaa cacaccgccc tccgcctcgc cgccgagcag gccggactgc gccgcaccac
    14521 caccgaatcg ctcgccaatc tcggccgccg caaccagaac ctcgtgcgtc gtcagctcag
    14581 gctcatcacc aggctggaac gacaggaact cgacccggac gccctggccg agctcttcga
    14641 gctcgaccac ctcgccaccc gtatgcggcg caacgccgaa aacctgctgg tcctggcggg
    14701 gcagaatcca ccgcagccca cggcagcacc ggccggcggc ctggaagtcg tccagtccgc
    14761 cgtcgccgag gtcgagcagt accggcgggt actgatcgcg accgtggagc cggtgcggct
    14821 gcgcgggcac gccgtcgccg atgtcgccca cctccttgcc gaactcatcg agaacggcct
    14881 gactttctcg ccaccgaccg aaccggtcga ggtgcacggc tggtacgaca ccgaggacga
    14941 cacgtactgc ttcgccgtcg tcgaccacgg cgtcggcatg tcccgggccg acaaggaacg
    15001 tgcccacgcc cgcttctccg actccgggga ggaggccctc atcgccactc ccacccgatt
    15061 cctcggccac ctcgtcgtcg gtcgactcgc ccaccgcctc ggggaaggca cccgagtcca
    15121 cctgttcgac accaccggcg gcggcctgtc cgcgctcctc gcgctccccg ggcgcctgct
    15181 cgcccccgcg gagaacccct ccgcctcacc cccgcccgcc cggcccgctg tctcctccct
    15241 gctcaacggc ttcagagcag gtgtcgctca tgccgaagcc cgaaccactc aaggagcgtc
    15301 atcgtgacca ccgccgtcca tagtttcggc tggctcatct cggagttcgt acgcaccgcc
    15361 gacggcgtca ccgacgccgt cgccgtctcc tccgacggcc tgctcatggc agcctcggac
    15421 agcctcggcc gagatcgggc cgatcacctc gccgccatcg tctccggcat caccagcctc
    15481 gcccagaacg ctgcgacggc acacggcttc cacggcatga aactcgtcat gatcgaaatg
    15541 ttcggcggct tcctcatggt cggtcgtatc cgcgacggaa gctgcctcgg cgtcctggcc
    15601 gccgaggggt gcgacgtcgg cctggtcggc tacgaaatga ccgtgctcgc cgaccgcgca
    15661 ggcgaactgc tcacgcctca gttggtacgc gaactccact gcgcgcccgt ggctgcggga
    15721 tagtcgcggc acgatcgggc ccacccgagt tgctcaggat gggcatgagc caggcgagca
    15781 cggtcggtgc gccgccgacc gggagaacgc ctctcacgct cgtccgtgca catcacgcga
    15841 tgcaacttgc cgactgtgca cggggcgtgc gcgccacggc gcggctcgcc catgactcgc
    15901 gaaatcggag catgcggaaa accgggtcag ctgctgtttt tcgggcacca tatgcgcgcc
    15961 accgcttcct gggaaaaggc tccgacccgc gcattccatg cacagccgac aaaggccctc
    16021 cgcgcgcatg ccccgaggca gacaaaacaa agaaaccgca ggtcaaatcg ttgacctgcg
    16081 gtttcccatg gagccgcctt cgggattcga acccgagacc tacgcattac gagcccgata
    16141 gggatcgtgc cgggctgcgc atgcggtcgc acgagatccc atcccatatc agagcgcatg
    16201 tcgcaatcct gcttatcgcg cccgtgttgc accgtccaac ggcgtccgcg ctccccttgc
    16261 ggtcccggca tgtatttgag cggacagtcc gtcgtccaga ccgtactggt acggcttgtc
    16321 gaggtcacac aagcgcgaga actccccacc agggagggcg tcgtgaccaa atcccccgca
    16381 tgctcggcag acgccgcctg gcggcacacc ctcgtcccgg accgagaggg cctcgcacgg
    16441 cgctcagcgg actcaccgaa tggctcgccg cacccaaagc cgagggcgtc cgtgtcgtca
    16501 ccaacgcatc gccgcagcca gcctgcacgg ccacacgtac gccctcaccg ccgtagtgac
    16561 cgccaccgca ttcacccagg acaggtcgca ctcgcggaca ccgcaaggct ctgtttcctt
    16621 gagacccgac tggccaggcg tcgtccgccc cgcagcccgg tctcacgtgg aaccggcgcg
    16681 tgccgtggtc ctccgggagc ggctcagccg ccgcctcacc ggccccgtcg gaggcacagg
    16741 cggatgtcgt tcaccatctg gtcgatgagg gattcgacgg cgttgcggaa gtagaagtga
    16801 cctccgatgt gggtgcgcac gccgaggaac ccctccgtgc acgcctccca ggcgcgcacc
    16861 gcccgaggtc cggccaggtt gtcgaactcg ccgcagaacg cggtgatcgg ggtgcccagg
    16921 cgtggccgtg gttcgggcgt ccaggtagcg atcatgtcaa tgtcgctgcg cagggccggc
    16981 tcgatgaggg cccatagggc gtcattgccc aggatgctct gttgcagccc gccgagctcg
    17041 gcggtcatgg cgcgtaggtc ctcgctggtc ggtggccgtc gggcggggcc actcgggagc
    17101 tgctggggtc cgctgtgcgc ggagaccccg agccacacgg ggttgggcag cccctgtcgg
    17161 cgcatcacat gagccagttc gtagcagacg agggcgccca tgctgtgccc gaacagcgcc
    17221 agggggcggt cgcccagcgg ggccagtgcg tcggcgaggc ggtggcagaa gcgcgtgacc
    17281 gtctcgccgc cgaccgtggg ggcgccggtt cggcgggagg cgacccagac ctcccagcgg
    17341 gtggggaagt gctggaccca cgagcggtat tcgcgatgcg agccgcctgc gtggtgcatg
    17401 aggagcacac gggcctcggg gtcggcgacg ggccggggac agtgcacgag cgtgtcgtgg
    17461 gatcctcccc cggcgttctg cggcaggagc ggcatgtacc tcactggccg tctgcctcgc
    17521 ttccgcctcc gggacggacg agagccgtga ccgcctcgcg gatgcgcgga tcgtcgaacc
    17581 ggcaggcgag cgcgatgatg ccgtcgggcc gcacgaggac catgctcgga cggtcggcgc
    17641 ccaccgagga gtgcgcggca cccatcgggt cgtgcagttc accgcggtcc gctgagagcg
    17701 gtgcgccgcg agcgaccagg acggtgtgga gccggtcggc gtccgggccg agggcggtcc
    17761 gtgccttggt gagcaggcgg cgggccgagg cgaggtgggc gggtttgttc cggtcggcgg
    17821 cgaaagcgta cagggtgggc gtgtgcaggc tcagcgcgtc gcgtagccag ccggtggcca
    17881 ggggcgcgtc gggcaggcgc atgccggggc ggaccggccc gatgccggac tgttcgctcg
    17941 ggtaggcgtt gctcaactgg gcgagcctgc tcggcacctg acggtccagg aagccgacgc
    18001 gctcggcaac cccgagcagt aggtcgcgta cgacggcccg ccaaccggtc agcgtccaca
    18061 tccgctgctg ccggtcggtg tcggccacca cgatgcctgc catgtgctcg cgttcgcgcg
    18121 cccactgctc caggctttcg gcgggcaggg tccgctgctg gacgcgggcg agcctccagc
    18181 ccagggcgtg ggcgtcctcg atgccggtgt tgaggccctg tgcaccgacg gggctgttga
    18241 tgtgggcagc gtcgccgagg atcaggatcc ggccggactt gaagcgttcg gccttcctgc
    18301 ggtggacgcg gaagtcgccg gtcttctgag ggccgacgag tcgcagtggc accgggcagc
    18361 gttcgtcggc ggcccgctgg acgaaggcga ccgggtcgtc cacctcgagg tgagcggggg
    18421 cgctggcgac cacccgatag tgcccaccgg gcagtccgag aacggtgatc acccccttgt
    18481 cggtcatgaa gtggtgtgcc tcgtcgtgcg cgaggccggt gtcgcaggtc ccgtcggtga
    18541 ggacgaattt cagttcgtac ggggctccag ggaagggcac gtccatgagt tcgcgcacct
    18601 tgctgtgcgc cccgtcgcag ccgatgagcc agggtgtcca ttccttccag gtgcggcctt
    18661 cggagcgcag gaccacctcg acgccggcct gcgccgtccg gtggccgacg acctcgacgc
    18721 cgtactcgac cttgccgccc agttgctcga agcgatcccg gacggcgcgc tcggtgtcct
    18781 gctgggggat cgacacgggg gaggtgaaac gggaaccggg aaggtgctcg aagttgatgc
    18841 gggccttgcg ccgcccgccg gagtagtaga cctgaccgtg gatctcgatg gagcggtccg
    18901 cgatgtcctc gccgacaccg aggcggtcga gtatctccag cgaccgcggc cagaggacca
    18961 gggccctgga gtgcgggtgc ggccgctcca cgcggtccac gacccggacg ggcacttcgc
    19021 gcaggaggag ttcgacaccg agcgtcaggc cggtcgggcc cgcgcccgcg atgacgacac
    19081 cggattgctc actcattctc atctttatac gccccctata actattcccg aaaaccagcc
    19141 cgcacttgcc gatggccgat tctttgcggt ctctgaataa acacgctccc ccgccgtccg
    19201 caacgtgacc ccgctcacag ggaaaaccct gagccttggg tatggtgaca accacggggg
    19261 ttcagtgatg cacccttttc gagttctcag taagttaccc gaaaaggatc aacgttttga
    19321 attcgaatgg gaccattcac atacttgtcg ccgacgacca tgtacttcta cgcgaagcac
    19381 tctgcgacgt cctggaaatc aacccggact tcaaggtcgt ggcgcagtgc ggcgatgccg
    19441 agcaggctgt ggcgcgctca gcggaggaac ggcccgatgt cgccgtactc gacgtggaga
    19501 tgccgggcaa cgattctgtg gcgaccatcc ggcgcatgcg cgcggtgtcg cccgatacca
    19561 gaatcgtcat actgaccatg catgccgatc accgactcgt acagcagttg ttccgcgagg
    19621 ggattcgcgg atttctgcac aagagcatca gccggcacgc tctgacgtcg gcgatccgca
    19681 gcattcacgc ggacccggac cgagtagttc tgtccatggc gaaggaacac ctgggacttg
    19741 acgtcccccc ggtggcggcc acgctgtccg atcgcgaggt cgagatactg agcctggtgg
    19801 cgacggccat gacgaaccgc cagattgcca gtcgcctcgc gatcgccgaa gggacggtca
    19861 agctgcatct gcacaacgtc ttccgtaagt tgaacgcggt gtcacgtatc gacgcggtca
    19921 acaaagcctc ggccgcatcg ctgatcgact ggcccgccac gagtcgcggc gctgcgcgat
    19981 gacgtggtcg cggcccgtcc tcacgcccgt tcgcgcacca cgaggcatcc gaggttgccg
    20041 tccggagcca gtgacgtcac gaggccggta cgcctttcgg cggcaggctc cgcctgccac
    20101 agcgccagga gtgcggccag ctgaaacgca ccgtgggcgc tgtacagctc gcccaggaag
    20161 tccccgatcc gcacctgccg ctccggtacc gagccgagcg ctgcggccag cgcccgctgc
    20221 tcgatgtgcc gcagcccggt gtagtgggcc gcgccggggg cgaccacgct cacgtccccg
    20281 ggagcgacgg cactgcggtg gagcgcgcga ctgatcacgt cggtcagccc ctgcacctgg
    20341 cggccccggt gggcaggggc gccgtagtag gcgacctcgc aggcgaggag gttggcgcca
    20401 agaggcggcg cggcgtcggt cgccggtccg ccgtgcacca tggagccgtc ggccggctca
    20461 gcacattcct cgttctgcgc cgacaccgcg aacaccgccg ccccctcacc gatccgggtg
    20521 cccggccgca ggctgccgcc atgctgccat gcccaggcag tctgcgggct gagctcctcc
    20581 acgccgccaa ccagcaggcg ccgagcccga ccactgccca gggcgttgtg ggcataacgg
    20641 aaggcgaaga ggctggagag ctggccgccg gccaccgtgg cgttgacccc gcgaagctgg
    20701 ttgcggatgg ccacctgacc ggaacagcag ttcatcaccg tattcgggaa atgcccggcg
    20761 ttgaccaggt agggccgctc ccggaccagg gtgtcgcggc agaactcggc gctgctgcga
    20821 acactgcccg tgctggtggc catgaccacc ccggtatcgg tgttcccggt gccgtcggcg
    20881 gcgtacgagt gcagagcctc gccacacgcg accaggccga gcttcgtcgt acggtcgaga
    20941 tggcgcagcc ccttgcggcc gaggagcccg gcgaagtccg ggtcggggac ggggcgcagc
    21001 gggagatcgg ggtactcacc ggggctgggg tccgggaggg gagcgtcgga cagcttcccg
    21061 gtgatgaggg cctcagccag ggcagttagg ccgaggccgg cggcggagac caccccggcg
    21121 ctggtgatgg tgagcggccg cacggccggt gccgacgtcg tcatacgacc ctccccatga
    21181 tggtgatggc gttgtttccg ccgaaggcga atccgtggtt ctgggccacc ttcggttgcg
    21241 cgggccgggc cacgttcggc acgcagtcca cgccggggcc gagagccggg tcggtcagct
    21301 cgacgtttgc ggtgggcggc aggaacccct ccgcaagcgc cttgcagcac accagcgctc
    21361 cgaagccgct cgccgcaccc atcgtgtggc cgatcatcga cttgatggag ctgatgggcg
    21421 gcatggcact cccgaacacc tcccgcacag cagccacttc cgtcgcgtcg ttggtgggcg
    21481 tgccggtccc gtgggcacag atgtagtcca catcgtcgga cgtgatgccg gcgctgtcgt
    21541 gggcggcgcg gatgcaggcg gagatactgt gcgggtcggg gtggaccatg tgcttggcat
    21601 cgcagttcac cgcgtacccg aggacctcgg cgtagatgcg cgcaccgcgc tcgaccgcgt
    21661 ggtcgagggt ctccagcagc agcgccactc cgccctcggc ggtgatgatg ccggagcggc
    21721 cggcgtcgaa ggggcggcac acggactcgg ccagggcgcc gagccggtag aaaccggcgt
    21781 gcgtgtagcg gttcaccgag tcggctccgc cagccagcat gaagtccgcc tcaccgctgc
    21841 gcacaaggtc ataggcgtag cccagggcgt agttgctggc ggagcaggcg gtggggattg
    21901 tctgcgcgtc accggtcagg cttagctcgt agttgaccgc gcccgcgata cggctggccg
    21961 gcagctgccc caccaggcgc gggtcgagac ccttcagtcc ccgggtcgtc cactgttcgg
    22021 tcaggctctg cacgacggtc gactctccgc tggtggtgcc catgatggag ccggctgccg
    22081 agcgcgacag ctcttcgggg tcgagggcgg agtcggtgac ggcgaggcgg gcggcggccg
    22141 cggcgagctg actgctgcgc ccccacgcgt cgggccgtac gtggtcgagc agcgaaccgg
    22201 ggtcgaagtc cgggacctca ccggcataca cgtgcgggaa gccggtcgtg tcgaagctgc
    22261 ggacggggct gaccccgctg cggcccgccc gaatggcggc ggtgaagtcg tccgccccga
    22321 tgcccaggct gctgaccgcg ccgaggccgg tcaccacgac ccggcggtcg gacggctcag
    22381 gcatcgatgg gctcccccgc gtaacgggcc acgatcgcct gcgtagcccg gatgtcgacc
    22441 atgttgttca tctcttcctg aggaacggac acatgcagtt cccgctctat gcgcgcgaat
    22501 acctggatga gggaaagcga atcagccgcg tagccgtcga cgaagctggt ggaatcatcg
    22561 acctcgctcg actcaagttc gagctcctcc gcaacaatgc tgcggatcag ttcgagctgc
    22621 ttgctcgggt tggtgaccgc cattccgttc tgcgccattt ctcgatcctc cctcgttttc
    22681 tgcgaacacc atgaaggtat gcggttgtcg acccgcggcg aaaggcctcc tccccgcaag
    22741 agctagcggt catatatcga aggttatagc cgcccattac ttgcgagata cgggccgctt
    22801 gtgcacgtca ctcgcgtgtt tcactgcgct caccagccca taaaatggac agcgaggagg
    22861 cgacgtgtcc caaagactcg ccggtcggaa accggcgacg gatgtgcaat tcagccgcac
    22921 ggtggagagg gctctcgtgc accgtgccgc cgtggccgaa gtcttcgtga ccgacatgcg
    22981 gaaagtgggc gaggaccgct accttgccgg agcacagctg cccctgtcgc acgcctacta
    23041 cagcgatcac cggcagacgc cacggctctt cgacccactg ctgctactgg aggcaagccg
    23101 acaggccgcc gtatacggcg cccacaccca cctcggcatc ccgctgagca cctcgttcct
    23161 ggtcaactcc ttgtccgtcg tcttcaacga cgcgacggcg ctgcgcatgg gcggccaccc
    23221 cggggaactg cacctggcga cgagctaccc cgccgtacgc cgtcggggcg acgagttccg
    23281 cgcggtgggc gtcagccagg acctgtacct ggacgggcgc ccttcggggc gggtgacgat
    23341 gagcgtgagc tcgatgtctc ccaagcagta ccgggccctg cgctatctgc agcgcgacag
    23401 cgagccgccc acgaccgagc gggccccgct gacggccggg gtggcggctg cggccgccgc
    23461 ggtggctcgg gagagcgcgc taaacgtcgt cgtcagccgg cccgtcccgg agggcgagga
    23521 ggttcgggca gcgctcgtgc cccggtacga caaccgcagt ctgttcgacc acacctacga
    23581 ccacgtcccc gcgatggtgc tggcggaagg cgcccgccag ctcgcgctcc tggccgtcgc
    23641 cgacaccggg gtcccggtgg aacggacttg gatatccgat tgctcggcac ggttcctgcg
    23701 gttcgcggag ctcgatcagc ctgtgctgct gagcgcaccc cgccgtcccg cggccgaggc
    23761 aggtttccac caggtcccgg tacgcctgcg ccaccacgac accgagatcg ccgagatctc
    23821 cgtaaccgtc gcgaccctcc ccgaggaggg gatgtcatga gtgaggtccg agcggtctgg
    23881 agcgacttcg gtggtgttct caccccgccc cttgacgtga cgatggccga cttctgccgg
    23941 cgggtacacg tgccccctgc tgtcctgcgc caggccatgc acagggtcgc ggagggctac
    24001 gggacggacg tcatggctcc gctggacacg cccctggtgt ccgaggacga gtggtgccgg
    24061 caggtcgagg cggttctgca cgaggagcac ggcatcgccg ccgacctgac cggcttcgcc
    24121 gagaagtggt tcacgaaccg ggacaccaac gagccctggc tggccacgct gcgggagctg
    24181 cgcgagcggg gcgtgttcgt ggggctgctc tccaacatgg tcccgagctg ggactggtac
    24241 tggcggcgca tggtgccgcc gacgctcttc gccgggatcg tcctctcctt cgaggtcggc
    24301 cgccgcaagc ccgagccggg catctacgac tacgcagccc tcacggcggg cgtcgctccc
    24361 gacgagtgcg tgctggtcga cgacctggcg gacaactgct cgggagcccg cgccgcgggt
    24421 tggaaggccg tgcacttcac ggacacggtg tccgcggctc gtgagctgga ggagctgctg
    24481 accgtgccag gctccgttcc ggtttctccc gtccccgcga cttcagtccc cgtgatctcg
    24541 gataggtagg acccatgcgt tccgtactgg taaccggtgg caaccggggc atcgggctgg
    24601 cgatcgctcg ttccctcgcc gcacgcggcg acagggtggc cgtcacccac cgcagcggcg
    24661 agccccccga gggcctcttg ggagttcgct gcgacgtcac cgacgagaag tcggtggagg
    24721 aggcgttcgc ccgagtggaa gaggtgcagg ggccggtgga catcgctgtg gccaacgccg
    24781 ggatcaccaa cgacgggctg gccctggcca tgtcggacga ggacttcggc cgggtgatca
    24841 acaccaacct catgggtgcg ttccgagtgg ctcgcagggc tgccgcgcgg atggcgacgg
    24901 cccgttgggg ccgcctgctc ttcgtcgcct ccacggtcgg catggccggc tcgcccggcc
    24961 aggcgaacta cgcggcgtcc aagtccgcgc tgatcggcct cgcccgctcg atggcctggg
    25021 agctgggccg ccgcaatgtc accgtcaatg tgctggcgcc gggtctgatc gaaaccgaca
    25081 tgatcacgca tgtctccgac aagcgccgag cggagctgat ccgggagacc gccctgcgcc
    25141 gggtcggcac ggcggaagag gtggcgcggg tcgcggactt cctcaccagc gacgcgtcga
    25201 gtttcatgac gggcgcggtc attccggtgg gcggcggaca cggcatgggc cactgaccct
    25261 cgcccggtac gacggtggcg ggcacccctc cacaggggcg cccgccaccg tcgcaaagtc
    25321 actggcttca ggacgtgacc tgctctcgct gctcggccgt gggcttctca gccgtggcct
    25381 cccccggggc cggccgctcc gcaagcagga accacgcggc gacggtggcg acggcgcaca
    25441 gggcggccac cgaccacagc atgaggtgca tggcatcggt gtgcccctgg gccaggaagt
    25501 cgatgaacgt tgccctgtcg gcggccgaca ccgagtcggc cgcgtccgcc gcgttgccgc
    25561 tggccacgct gtcggcgagc ccgttgacgc tgctgtccgt ctgcgcctgg aacttcgcga
    25621 aaccgccgga caggctgtcg cggatcaaag tcaccagcac accgcccatc gcggcgatgg
    25681 ccaccgcttc accggccagg cgcatggtgt tgaacatgcc cgccgccata cccgcccgcg
    25741 cgggcggcac ggaggagatc gccgcgccgt ccatgagtcc ggacgacagg ccctgtccca
    25801 ctccgatcgt caccatcggg ccgatgagag cgccccatcc catgcccggc tcgatcaccg
    25861 tcagccaggc cacaccggcc gttgtgacca gcaggctcag ggtgagcagg atcctggacg
    25921 acatccccca ctgcaggaac ttggaggcaa gcagcggcac caccaggact ggaccggtca
    25981 gcagcagcat ggccagtccg gcctcgccgc tcgaccggcc gttcgcaccg atcaggtacg
    26041 agggcatcag cacgacgaag ccgacgaagc cgaaggagaa gatcaccggc agcatgcaca
    26101 gggcgacgaa gcgcgattgc cggaagaggg acacgtcgaa catcggccgg gcatgccgcc
    26161 gttcggcccc gacgaacgcc ccgatcagga cgaggaacac caccagcagc cccaccatgg
    26221 ccgggctcgt ccagccaatc cgcgccccct cggccaccgc cacggtcagt acgaacagcg
    26281 cgctggtgaa cgtaccggta cccacccagt ccacgctctt cgcctcgggg tcgcgggact
    26341 cgggcatgaa ccgcagcatg gccagcacga cgaccgcgat gaaaagttgg gacaggaaga
    26401 tgccgcgcca gccggacagg ctgatgatcc agccggagga cgtcgggccg atggcgagac
    26461 cggctccgat cacgacgccg gtgaccgcga aggcccggtt gcgcgcctcg ccgtcgaagg
    26521 ccgtggcgat gatcgccgta cccgccgtga tcagcgacgc cgagccgacc ccggccagcg
    26581 cccgcgcgac atcgagcaga tagatgttct gggcgagcgc acaggccagc gagctggcac
    26641 cgaacagacc ggcgccgagg gcgaacatac ggcggcggcc gacgatgtcg gccagcgaac
    26701 cggcggccag catgaagctc gccgcggtca cgttgtagcc gttgacggcc cactgcaacg
    26761 gaccgatgtc ggcgtgaagc gagcggctga tcgccggcag ggccaccgac gtgccgctca
    26821 acgacaccgg aaccatcagg acggcgagac agacggccag caggatcagg ccacgccgtg
    26881 gcggggccgt gacggcgttc gggagggtac tcatcagtga ttcatctcca tgacgatggg
    26941 gacggcatgg gccgagtggg gagagaagac ggccatgcac aaccgtccgg cgccggcccg
    27001 cgggggattc gaaccggcac cggacggggc ctcggtgccc ggactgagcc gaagggtcag
    27061 ccggcgaaga gctccttcaa gaaggcgacg gccgtgctca gggccgtgtt gtgctcggcg
    27121 gcggcgtaca ccaggtcctg gtgggtcagc tccacgtcgg tgtgggcacg gacgtacggg
    27181 atcttcgtgc tggtgccgag ttcctcggcg gccgaggcga cggtcccgtt cgtcagcccg
    27241 ctgccgaagg cgtacagcgg cacgtcgatg tcggcggtgt ggaacaggcg gagtccgagg
    27301 agccgcgtca cctcgttgtc agtgaagtcg ttgcctgcga cgtagtcgag catgacccgg
    27361 ttgagcgcgt accagacgaa ggcaccggat ggccgcccgg cgtgtgcctc ggcgacgcga
    27421 agcagcggcg tcggcccctc gtcggcccag tcgccggccg cgtccaggcg gccggactgc
    27481 accgcgtacc cggggtgccc gacttccgtg cagaccagct tgccgaagag cccggcgttg
    27541 gtcagcggac cgtcggtggc gtagccggcg ggcagcttgg gctggagtac cgcgggtccg
    27601 tgcgggtcgt tgagggcgtg gcgggcggcc aggtggtacc agagcgcggc gtcctcgggc
    27661 tgctctccga cgcgtacggc gaggctggtc gcgttctcga agacggcgcc ctgctcgatc
    27721 tgtccgagcc atgccttcgc cgcatcgacg ttcagcgcga actccatgcc ggcgcccttg
    27781 aacgcgtcgc gcacaccgcc gtcgaactgc atcaggcccg cgaggtccgc atggcccggc
    27841 tgcccgtcga agtcccaggc cgcgtagtgc gcgaccgcgg cgcccccgac ggagtgaccg
    27901 cccaggacga cctgccggcg accgccgtca cgggccttga ggacgacgct gcggacgtct
    27961 tcgagcagga cgccgaggcc ccaggaggcc gcgaacggcg ccgatgcgcc gtcctgtcgg
    28021 acataacggc cgtccaggta ataggagtcc tggttcgcct ggtccgcgta gtgagtgagg
    28081 tcggcgaggt tctgctcgcg cctgtcgatc gcccagacct cgaggccggg cacggcggac
    28141 accagctcac gtgccagggt gagaaaaccg gccgcggcgc cctcgcgacc gcccaacatg
    28201 accagcacac gcggggcgtc ggctgggccg accttgagca ccttcacatg ctggacgtcc
    28261 tcgggccccg cggcccgcgc acccgcaacg acctccaccg tctcgcggcc gggacgggcg
    28321 ggctgggcga ccgccgggtt ggtctcttcg atggacatgg gtctccgttc tcaacagtgg
    28381 atctcccggg aacgtctcca gcctgtcggc gggcggatga cacaaccaga ggtgcgatcc
    28441 gcctaggcag atcacgacca ggctcgggtg cgcgcatggt ggtagggccg gcctgcccgg
    28501 aaagcacgag gtcacggcta ccaggtgggc agccgtgacc atggtggaaa tgccttgtcg
    28561 gaaagatggg cacgtgagcc gcacgggccg ggcgcctcga tcagctgccg gaagtgcctc
    28621 agccggccgt cagcgaggcc agcgccgcat cgacgggcag ccgccccgag acgacgtcga
    28681 aagcccgatg ggccgtggcg gcctgctcca ggcaggccac gacaacggct gccaggtcgt
    28741 cgcgtgcgat gctgccgtca ctcagcgccg ccccacccgg atacgcccct tgcctggccg
    28801 gtcgtgcaga ccaccgggcc gcacaccacg gtagggcggc ggtgcttgct cggcccggtc
    28861 ggccggcatc gcggagaccc gcacgaaccg ccgtacatcc gccgtctgcg cggcccggac
    28921 ggcggcaatc acgccgtccc ggtcgacggc gagcagctcc ggggaggtca ggtcggacac
    28981 acccgccgcg ttgacgacgg cctcgctgcc cgcgaacgcg gcggcgagcg gcggcacgcc
    29041 cgcgatgaga tcgccttgga cggcctcccc cgttatgttt ttcgcggtcc tgcaagaggg
    29101 ccgctggcct ccgggcccgg catgactttt gccccctgtc gaacggatg
//
