LOCUS       NZ_BMWB01000020        20546 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence20, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000020
VERSION     NZ_BMWB01000020.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 141557)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 104907
            Orig. end                         :: 125453
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20546
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="1"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20546
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20546
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10546](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10546)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     gene            complement(305..643)
                     /locus_tag="IE198_RS25590"
                     /old_locus_tag="GCM10010381_51880"
     CDS             complement(305..643)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047013.1"
                     /locus_tag="IE198_RS25590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51880"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_189890561.1"
                     /transl_table=11
                     /translation="MTADTPLGGRLDDDDYPAYTMGRAAEMLGTTPGFLRAIGEARLIT
                     PLRSEGGHRRYSRYQLRIAARARELVDEGMPVEAACRIVILEDQLEEAQRINAEFRRAA
                     AAERDGSQ"
     misc_feature    complement(1262..1276)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     gene            1310..1684
                     /locus_tag="IE198_RS25595"
                     /old_locus_tag="GCM10010381_51890"
     CDS             1310..1684
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743744.1"
                     /locus_tag="IE198_RS25595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51890"
                     /product="hypothetical protein"
                     /protein_id="WP_100108196.1"
                     /transl_table=11
                     /translation="MSNADELLVDIAATVESEQSNQMSLTVVIGGAVITGRLAPEAVWR
                     ERVSEVLRDSERLRPFSGVFSAEQTRGRPHRGEPPTHLHFHVARILQGSVGIPETGGMY
                     RVAIKDVSGWTVGDFSYSDH"
     gene            complement(1827..2135)
                     /locus_tag="IE198_RS25600"
                     /old_locus_tag="GCM10010381_51900"
     CDS             complement(1827..2135)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006375223.1"
                     /locus_tag="IE198_RS25600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51900"
                     /product="SCO5918 family protein"
                     /protein_id="WP_189890563.1"
                     /transl_table=11
                     /translation="MRCVIARFPFDLSKSGVLASMKGVRPEPITGDSVIIGRRHYPVMQ
                     VGEVITRQDRRDFTAGEVTRAVTRLGFTCRTQPVATPARDLTPFEEAVAMLGNSSAV"
     gene            complement(2142..2585)
                     /locus_tag="IE198_RS25605"
                     /old_locus_tag="GCM10010381_51910"
     CDS             complement(2142..2585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719282.1"
                     /locus_tag="IE198_RS25605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51910"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_189890565.1"
                     /transl_table=11
                     /translation="MTLVQTKPRPARSTARTVVDAMDAPGPQVWDDMTVEVALSVMAGA
                     RAQHLLVSDEDGRCTGLITRSQLTGVRDSCAYTDRVRLRDVLGEAGPFPSPVTMLVEAE
                     HAMRYRQLGSSPVVDEHGCAVGVLTLPHRSAGVPPAGPFSVNL"
     gene            complement(2632..4149)
                     /locus_tag="IE198_RS25610"
                     /old_locus_tag="GCM10010381_51920"
     CDS             complement(2632..4149)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145517.1"
                     /locus_tag="IE198_RS25610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51920"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_189890567.1"
                     /transl_table=11
                     /translation="MNRTRTNDRSTRTRNAGSYSGKGGSRSGTSASNRSRTAGRSGGYG
                     RRPAAPQGEFAPPVTVTPALPAVEAFADLDMPRPLLAALVTEGVTVPFPIQAATLPNSL
                     AVRDVLGRGRTGSGKTLAFGLALLARTAGRRAEPRQPLALVLVPTRELAQQVTDALTPY
                     ARSVRLRLATVVGGMSIGRQASALRGGAEVVIATPGRLKDLIERGDCRLDQVDITVLDE
                     ADQMADMGFMPQVTALLDQVRPGGQRMLFSATLDRNVDLLVRRYLSDPVVHSVDPSAGA
                     VTTMEHHVLHVHGADKHRATTEIAAREGRVIMFLDTKHAVDRLTGHLLNSGVRAAALHG
                     GKSQPQRNRTLAQFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPSDHKDYIHRGGRT
                     ARAGESGLVVTLVTPDQRRGMTRLMSDAGIRPHTTQVRSGEAELSRITGARTPSGVPVV
                     ITAPVTERPGRSASASRGRRGRTARNGRTGQAARRTAQRQSAFDAAA"
     misc_feature    complement(4120..4133)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.68"
                     /tool="antismash"
     gene            complement(4519..4722)
                     /locus_tag="IE198_RS25615"
                     /old_locus_tag="GCM10010381_51930"
     CDS             complement(4519..4722)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119326.1"
                     /locus_tag="IE198_RS25615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51930"
                     /product="cold-shock protein"
                     /protein_id="WP_004986771.1"
                     /transl_table=11
                     /translation="MATGTVKWFNAEKGFGFIEQDGGGADVFAHYSNIAAQGFRELLEG
                     QKVSFDIAQGQKGPTAENIVPA"
     misc_feature    complement(4678..4689)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.36"
                     /tool="antismash"
     gene            complement(5262..5435)
                     /locus_tag="IE198_RS25620"
                     /old_locus_tag="GCM10010381_51940"
     CDS             complement(5262..5435)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_51940"
                     /product="hypothetical protein"
                     /protein_id="WP_189890569.1"
                     /transl_table=11
                     /translation="MNGIDRNDLDEVIAKTFNEVKTAVNTHSEKSLQMYSGALRALVEL
                     RQQILSEERVAR"
     gene            complement(5461..5886)
                     /locus_tag="IE198_RS25625"
                     /old_locus_tag="GCM10010381_51950"
     CDS             complement(5461..5886)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_51950"
                     /product="hypothetical protein"
                     /protein_id="WP_189890571.1"
                     /transl_table=11
                     /translation="MRARTPVAAAAAVGALLAVATPATAEDGGKPAGTVAWSAGHESAG
                     AAGERWIEQPGDLVISGKLSNTGEGCYSVWTRFVNDFAPGPLRKQAEVCGAGAVDVHVR
                     QAYRPTTTGRLTVCKGTEDVKDCGPWQNITSWPVNRD"
     gene            complement(5886..7352)
                     /locus_tag="IE198_RS25630"
                     /old_locus_tag="GCM10010381_51960"
     CDS             complement(5886..7352)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435957.1"
                     /locus_tag="IE198_RS25630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51960"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_189890573.1"
                     /transl_table=11
                     /translation="MSLTTNAAIVGTGPNGLAAAVTLARAGLSVSLFEAADTIGGGLRT
                     EPLFDQDVVHDICSAVHPMAAASSFFRQFDLPARGVRLLQPDMPYAHPLPDGRAAAAWR
                     SVTRTADHLGADGPRWARLMQPLADRSRSVVDLLLSDQRTLPADLLTPLLLVRRVLAHA
                     TGRTPFTTEPARALLAGVAAHAVGKLPSVASAAVAMLLAHTAHSSGWPLPQGGSARIAD
                     AMAADIAAHGGVFHTGHRVRDLAELGDFPLVLLDVGPRELLAIAGERLPSGYRRALRRF
                     RYGPGAAKADFLVCGPVPWVDPLVRQAGTVHLGGTRADIFRQETATAAGKPVPDPFVLV
                     VDPAVTDPSRAAGGRRPVWAYAHVPNGDTRDPVDLIRRRIEEYAPGFTDTVIASRGVSA
                     AQYATYNPNYVGGDIAAGAMTLRQSLARPTARRDPYTTPLPGVYLCSASTPPGPSVHGM
                     CGHLAALSALRRHHGIRTAPDLSPRKKELI"
     gene            complement(7349..9067)
                     /locus_tag="IE198_RS25635"
                     /old_locus_tag="GCM10010381_51970"
     CDS             complement(7349..9067)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132584.1"
                     /locus_tag="IE198_RS25635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51970"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189890575.1"
                     /transl_table=11
                     /translation="MNTSVIVRRHRLLLAAGTLLGLVGTGATLVQPLLIGDLIKAVATD
                     RPVLWPIVFIAALFAADAALAATHFYLIGRAGENIVLDMRTTLTGRLLHAQVRAFNKLE
                     HGDVFTRTVADTSIARIALSSSVAQMITSGFTAVGCIAVMAWIDWQMLLATAGCLGAAS
                     ATALGLARAVRRAAVENRTDTSDYGSGLLRVLGALTTVKASRAEQREEERLRTLADAAR
                     DSGLRVTRLSAMLMPAMNVGTQVSLAVVIAWGMARTATGALPVEQLTAFIMYLFYLVSP
                     LVMLFMALGEFQQGRAAIDRVRELAAVEQEETGAAMGPGTVEGAPAVEFETVTFSYGDT
                     AAPAVSDVSFSLPATGVTAIVGPSGAGKTTLFQLVERFFTPDRGTIRLAGADTATMPLG
                     ELRARIGLVEQDSPLMRGTVRENLTYARPDATDADIAEALEAAHLTKVVEALPDGLDTE
                     LGEGGTGLSGGQRQRLAIARALLTRPDVLLLDEATSNLDSDSETALRDAITTIGGRCQV
                     LTIAHRLSTTIGADRILVIEDGRLRAMGTHDELMDGDSTYRRLAGRQLAPAGAAT"
     gene            complement(9064..9243)
                     /locus_tag="IE198_RS25640"
                     /old_locus_tag="GCM10010381_51980"
     CDS             complement(9064..9243)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_51980"
                     /product="hypothetical protein"
                     /protein_id="WP_189890577.1"
                     /transl_table=11
                     /translation="MLTANRLTWFAIAFAFAVPSMLVMFRDDGVITRDSWIKGFVFAAT
                     IAAVIAAVFGKGSR"
     gene            complement(9267..10004)
                     /locus_tag="IE198_RS25645"
                     /old_locus_tag="GCM10010381_51990"
     CDS             complement(9267..10004)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="IE198_RS25645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_51990"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_189890579.1"
                     /transl_table=11
                     /translation="MTQPAQGGRDVQYGTAVASVYDSLIAPALPAEAAVDRLRPYVTGA
                     RVLEIGVGTGRVAVPVAAIAAEVVGLDNSRPMLDEFRAKTVPGNATLVQADFRAPLPVT
                     GPFDAAYSTMGSLACVTDREQLTAALSHVRDVLAPGATLSMEYYATGTYRPLVAQHTVT
                     MPTPHHGGTTTFTITLDDRDVLTMGTRIDEAGKPPVEFSEHVLLIERDEVEGCLDRAGF
                     TVEHVYAAESPQPYDWYTARATK"
     gene            complement(10001..10546)
                     /locus_tag="IE198_RS25650"
                     /old_locus_tag="GCM10010381_52000"
     CDS             complement(10001..10546)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_52000"
                     /product="hypothetical protein"
                     /protein_id="WP_100108205.1"
                     /sec_met_domain="cypI (E-value: 3.1e-29, bitscore: 95.3,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRTSTVMERAVPAILAGWFVASVLGQHPDRSYDKVRSGDKTGTG
                     ILIPNWRFFAPNPAVEDQHFLYRLANEDKTEHTEWREVYSIAPRKLIHAFWFPGRRAEK
                     AIFDVASTLLNNPGAMTPLHKEAKESAYLLVNEFVRRRLTPEPGFPLFQVLLVRYSGYD
                     HSEDPKYDMVFDYEEVNP"
     gene            complement(10543..11559)
                     /locus_tag="IE198_RS25655"
                     /old_locus_tag="GCM10010381_52010"
     CDS             complement(10543..11559)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (63-166). E-value:
                     6.3e-13. Score: 40.8. Matches aSDomain:
                     nrpspksdomains_IE198_RS25655_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="IE198_RS25655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52010"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_189890581.1"
                     /sec_met_domain="PF00561 (E-value: 4e-11, bitscore: 36.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-16, bitscore:
                     54.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRMTFPKLTTAGMAACLAAGLAHQGYATLATRSGHAGFERHRLR
                     CDSGNLITYHVRRGAAGGPTLVCDAGLMNSSAAWLLVADHLDPAISVVLHDRAGYRTSL
                     RRCPEDYSLGESVNDLVEVIADAVPTDGPCVLTGHSLGGYLAHRAAAAAPDRVHGLVLV
                     DPTHPRELLHSRRQREGSRGVNLTMKLGPWSSVFGTGLLIDKKGLFSFAEGSPHLRTLR
                     LEGSAPSTWRAGRREWDYSYAFMLDGGRPLDRLRIPVSVVAADSTMRDTPEHQDLYDEY
                     VASGNGGRIVTIPGSSHLSITGGVEHAPLTTRAIEDAVAAAAAQYAGEDRQEQGATA"
     aSDomain        complement(11062..11370)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS25655_Abhydrolase_1.1"
                     /evalue="6.30E-13"
                     /label="IE198_RS25655_Abhydrolase_1.1"
                     /locus_tag="IE198_RS25655"
                     /protein_end="166"
                     /protein_start="63"
                     /score="40.8"
                     /tool="antismash"
                     /translation="PTLVCDAGLMNSSAAWLLVADHLDPAISVVLHDRAGYRTSLRRCP
                     EDYSLGESVNDLVEVIADAVPTDGPCVLTGHSLGGYLAHRAAAAAPDRVHGLVLVDPT"
     CDS_motif       complement(11107..11169)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS25655_0001"
                     /evalue="1.70E-07"
                     /label="NRPS-te1"
                     /locus_tag="IE198_RS25655"
                     /protein_end="151"
                     /protein_start="130"
                     /score="23.7"
                     /tool="antismash"
                     /translation="DGPCVLTGHSLGGYLAHRAAA"
     gene            complement(11556..12392)
                     /locus_tag="IE198_RS25660"
                     /old_locus_tag="GCM10010381_52020"
     CDS             complement(11556..12392)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_52020"
                     /product="hypothetical protein"
                     /protein_id="WP_189890583.1"
                     /transl_table=11
                     /translation="MLSRLRRAAESACAKPLTTAERLSAATHLLSSLEYIVRRTDREPG
                     GLNDWTHTRAQVPAKTRTMQAVKDFIAREPVTQVLHTSRALAAAVLISPVKNNKVRMVA
                     NAYLAGSQLLIYPRHLFGTDGSDQVSFLVQTAAALGRAGGTDATRNAAVQFIGAQTVLS
                     YGASGWAKLPGDAWRSGDALAKIMRTQTYGDEWFYNQLEKYPAVSRAVCHTVLALECGF
                     PLLLLKKGKYIDAGLLVMGTFHVANARFMGLSRFAWAFASTYPSVRALAKGTGEAA"
     gene            complement(12507..12686)
                     /locus_tag="IE198_RS25665"
                     /old_locus_tag="GCM10010381_52030"
     CDS             complement(12507..12686)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_52030"
                     /product="hypothetical protein"
                     /protein_id="WP_100108208.1"
                     /transl_table=11
                     /translation="MSVLVEKVNAGAGHAADGSIAPVMATPAAFVAGVVAGGKVSAVIT
                     AAAGVGAAVKACQK"
     gene            complement(12790..12990)
                     /locus_tag="IE198_RS25670"
                     /old_locus_tag="GCM10010381_52040"
     CDS             complement(12790..12990)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_52040"
                     /product="hypothetical protein"
                     /protein_id="WP_189890585.1"
                     /transl_table=11
                     /translation="MLTHKVNADASLKGALTAGAPARGTAPVMATPAIFATPVIAKAAG
                     AVVGAGAVTGAAYAAYKTATG"
     misc_feature    13064..13078
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    complement(13132..13146)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.29"
                     /tool="antismash"
     misc_feature    complement(13163..13177)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.63"
                     /tool="antismash"
     gene            complement(13313..13492)
                     /locus_tag="IE198_RS25675"
                     /old_locus_tag="GCM10010381_52050"
     CDS             complement(13313..13492)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS25675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_52050"
                     /product="hypothetical protein"
                     /protein_id="WP_100108210.1"
                     /transl_table=11
                     /translation="MFLNKVNQDVSLEDFVAERGPEARIAPIMATPAIFTPAAVKVGVS
                     AGAAAAAYMATKVK"
     misc_feature    13478..13492
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.45"
                     /tool="antismash"
     misc_feature    complement(13674..13689)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(13684..13701)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            13829..14761
                     /locus_tag="IE198_RS25680"
                     /old_locus_tag="GCM10010381_52060"
     CDS             13829..14761
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018854361.1"
                     /locus_tag="IE198_RS25680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52060"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189890587.1"
                     /transl_table=11
                     /translation="MTPEESSHIHAEGVWRRYGRGKNAFDAVRGVSFTVRPGQLFALLG
                     TNGAGKTSTVELLEGLAAPHRGRIRLFGGLDPVADRGRIRPRTGVMLQEGGFISHLTVA
                     ESVEMWTRLTSRSRPVAEAVELAGLPHRADVMVQNLSGGERRRLDLAVATLSRPDVLFL
                     DEPTAGMDAEGRHATWRLVRSLQEQGTTILLTTHYLEEAESLADELAIMHRGRIAVSGT
                     VSEIVAGHSSTLSFGLPDKWTVHDLPVSGRVEQRGGRVTVTTGQLQQDAGRLLAWAERH
                     DVTLDRFTARPASLEEAFISIASQEGTAE"
     gene            14773..15522
                     /locus_tag="IE198_RS25685"
                     /old_locus_tag="GCM10010381_52070"
     CDS             14773..15522
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="IE198_RS25685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52070"
                     /product="ABC transporter permease"
                     /protein_id="WP_189890588.1"
                     /transl_table=11
                     /translation="MRHMKALFRIEWKLFNRIKANYIFVLFVPLMLLVSMRFVQDQMEL
                     DKHGLNPGPLMVSTAVGILLIFSLYSSVTGLYVARREELVLKRLRTGEVSDPVILAGGA
                     SMYIAIAVVQIVSVAVVLSVMFGVAPRQPLAAVAGLLTGVVLMTAMAAATAALCRTVES
                     VLVATLPAIFVLPMISGIYIPREVLPEALGDALLFAPLSPTVDLVRSGWTGELTAAGAS
                     IRGLLAIAWTALFAWLAARRFRWEPRT"
     misc_feature    14791..14804
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    14815..14828
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            complement(15846..17087)
                     /locus_tag="IE198_RS25690"
                     /old_locus_tag="GCM10010381_52080"
     CDS             complement(15846..17087)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059475.1"
                     /locus_tag="IE198_RS25690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52080"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189890590.1"
                     /transl_table=11
                     /translation="MAEGDRQPGKDSVDRSEGFGERLLGVLLDRAHEMPPQLIAPLIAE
                     EVARVGGRDISILLQDYAQLLLVPLPGRRLAVSEPEPIGDSHAGTAFLRAIPVEVPQAD
                     GIRMYLPLLDGSDQVGVLAVTMETVDDDDRRLLRRLAGLIADMLVTKHSYTDQFFLTRR
                     REPMSVAAEIQWSLLPPLAMSVPQVAVAGILEPAYHVAGDSFDYALNDDILHVAVIDAM
                     GHGLNAATMATVAIGAYRHSRRAGIDLAEIYTFMDRAIADQFGPEHFVTAQMMRLNITT
                     GHLQWVNAGHPAPLMIRKHRVIRRLESPTTFPVGFGGEEPQVSEQTLQRGDRVLCFTDG
                     LIEEHEAGEEQFGVEQLIHWVNRIEHAEEGVRAVVRSLSHTLKEERGGSTSDDATLFLI
                     EWRGGAADHLAVLE"
     gene            complement(17406..17678)
                     /locus_tag="IE198_RS25695"
                     /old_locus_tag="GCM10010381_52090"
     CDS             complement(17406..17678)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014178208.1"
                     /locus_tag="IE198_RS25695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52090"
                     /product="hypothetical protein"
                     /protein_id="WP_189890593.1"
                     /transl_table=11
                     /translation="MATLHERKNYREAIMRTLYEATEGNRLLGVAGAKLRDDLHMPEQD
                     LAAACTYLAGEGLITVDWARGNTPAMVTLTHQGIRFMEAEEEEPR"
     gene            complement(17723..17983)
                     /locus_tag="IE198_RS35545"
                     /old_locus_tag="GCM10010381_52100"
     CDS             complement(17723..17983)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014178209.1"
                     /locus_tag="IE198_RS35545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52100"
                     /product="hypothetical protein"
                     /protein_id="WP_229834331.1"
                     /transl_table=11
                     /translation="MKPPEPPADGRAEVRIVAASPETARRVAEVLRHCFAATEQRSYPA
                     GSEGGTRLHLTVDTTHTPRLARPWLAASRSSDQDRTQTDEV"
     gene            complement(18062..18313)
                     /locus_tag="IE198_RS25700"
                     /old_locus_tag="GCM10010381_52110"
     CDS             complement(18062..18313)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014178210.1"
                     /locus_tag="IE198_RS25700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52110"
                     /product="hypothetical protein"
                     /protein_id="WP_189890662.1"
                     /transl_table=11
                     /translation="METAITLSVIFAMITIGVLLIHLLNGQHHERIAAFHYGDALPGIG
                     RRGRKSRQRAEHAGSPVVPARPVASAHREDREGAADDA"
     gene            complement(18318..18887)
                     /locus_tag="IE198_RS25705"
                     /old_locus_tag="GCM10010381_52120"
     CDS             complement(18318..18887)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605539.1"
                     /locus_tag="IE198_RS25705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52120"
                     /product="DUF5994 family protein"
                     /protein_id="WP_189890595.1"
                     /transl_table=11
                     /translation="MTAIIDRMTISGRVASPPARLSLTPAGSVPGLLDGAWWPRSRDLS
                     RELPSLVEVLDACWGRITRVTVNPTHWPVIPRKVAVAGHTVHVGWFTDEQDPHKLILLS
                     YTAGRWDLLVIPPETGEAAAGRLMAAAAAAGGLAAASGLMASEDIARDARDALAREVEW
                     ETDGGHASAAGEQPNPTGPMSSVRGR"
     gene            19190..19714
                     /locus_tag="IE198_RS25710"
                     /old_locus_tag="GCM10010381_52130"
     CDS             19190..19714
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009716292.1"
                     /locus_tag="IE198_RS25710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52130"
                     /product="DUF5994 family protein"
                     /protein_id="WP_189890597.1"
                     /transl_table=11
                     /translation="MSDADTPRETKLLPDSIHEAVKPGTALLRLETTHVREGILDGAWW
                     PRSRDIGAELPSLISALTEHLGPVTRVGLDSSAWEELPTRLIIDDRVVHIDSFPVGDDT
                     VLITRGDRDHFSLLVIPPHATPDAARAAMARAVVADSATAEQILIDTGTGRTHPVATED
                     PRTGKERSDMR"
     gene            19720..19893
                     /locus_tag="IE198_RS25715"
                     /old_locus_tag="GCM10010381_52140"
     CDS             19720..19893
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061701.1"
                     /locus_tag="IE198_RS25715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_52140"
                     /product="hypothetical protein"
                     /protein_id="WP_189890599.1"
                     /transl_table=11
                     /translation="MVVFLLLIIVAIVLGLIGAVVEGLFYLLIIGVMVLVADLVLLRIR
                     VGRRQAPKRRLR"
ORIGIN
        1 cggtcatgag gatccggccc gggccgtttt tcgacatccc ggtgcaactg ttcgcagaga
       61 acgaggccgg cacgagagcc ggcgtgagac acgttcctgg tggtctcagc ctactccggc
      121 agccgaccgc cagggtgtac gcagccactc gggcgcgggg ccaccggctg catcggcggc
      181 cggtggcccc ggggcagcgg acagggcgcg gcgcgcacgg cactgtcgga ctccgtccct
      241 gcccgcgacg ttccgggggg cgacgaaccc gtgggctcca gccgggctcc gggcccgggc
      301 gggctcactg ggacccgtcg cgctctgcgg ccgccgcgcg gcggaactcg gcgttgatgc
      361 gctgggcctc ctcgagctgg tcctcgagga tgacgatgcg gcaggcggcc tcgaccggca
      421 tgccttcgtc gacgagttcg cgggcgcggg cggcgatccg aagctggtag cgggagtagc
      481 ggcggtgtcc gccctccgag cggagcgggg tgatgagccg ggcctcaccg atggcgcgga
      541 gaaagccggg agtggtgccg agcatctcgg cggcacgtcc catggtgtac gcggggtagt
      601 cgtcgtcgtc caggcgacca ccgagtggag tgtctgctgt cattctcacc tcgttgtgca
      661 acgcgtcgag gggccctggt gccgtacagc accagggccc cgaaggaaat tcaacaccat
      721 ctgtcggctc tacttgctgt gccgacctgc tgtgtccgcc actccgccct ggagagggcg
      781 agtgtgcggg gatcgcggat gcgtgaccgg ggaccacctt ccattccggg gtcttgcggt
      841 acccgggcgg ttcctccttg cccgggcgat cctgatggcg tctgcttcct ccattcctct
      901 gtcgaacttg ctactggctg gtgatgcgaa ctgctggtgt tgctgtcggc agcccctcga
      961 cctgcgggct gcccggtgcg cctgccagtc ccgtcgccgt cctgcgaaac atcgtggctt
     1021 cggaactccg cagtcgcacc gtcctgcgaa cttctcgtac tgctacccgc cagttcgtct
     1081 ctgccgggtc tcattgactc cgtctacgga agaaacgtta gccgggcagc agtccaatgt
     1141 ctactgtggc aagcatagat tttggacgtc cgtggccgag gtaatctccg tgcagcgagg
     1201 ggagtttccc cgctcgtccg gtccgggtca ccgcacgccg cggggagtgc cgccgcgtgc
     1261 gacggccggt gggccccgcc cgacgcggcg atgaatagaa tcggctctca tgtcgaacgc
     1321 tgacgaactc ctcgttgaca tcgccgccac ggtggagtcc gagcagagca atcagatgtc
     1381 cctgaccgtg gtcatcggcg gcgccgtcat caccggacgg ctggcacccg aagccgtgtg
     1441 gcgggagcgt gtgtcggagg tgctgaggga ctcggaacgc ctccgcccgt tctccggcgt
     1501 cttctccgcc gagcagaccc gagggcggcc ccaccgcggc gagccgccca ctcatctgca
     1561 cttccatgtc gcccggatcc tccagggcag cgtcgggatt cccgagacgg gcgggatgta
     1621 ccgcgtcgcg atcaaggacg tcagcggctg gaccgtcggc gacttcagct actccgacca
     1681 ctgagccacg gccaccggcc ctacggggcc ggccccggcc ggcgccgtcg tgccgaccgg
     1741 acgccgaacg cgacaagggc tcgaccggcc tgtgccggtc gagcccttgt cgcgtcctgt
     1801 ctccctgctt tcgcctcttc tgcctgctac acggcggagg agttgccgag catggcgacc
     1861 gcttcctcga agggagtgag gtcacgcgcg ggcgtggcga cgggttgggt acggcacgtg
     1921 aagccgaggc gggtcacagc cctggtgact tcgccggcgg tgaagtcacg acggtcctgc
     1981 cgggtgatga cttcgcccac ttgcatcacg gggtagtggc ggcggccgat gatcacggag
     2041 tcacccgtga tcggttcggg cctgacgccc ttcatcgacg ccagcacccc gctcttggac
     2101 aggtcgaacg ggaaacgggc gatgacgcag cgcatggtgc ctcacaggtt gacggagaag
     2161 ggtccggccg ggggaacgcc ggcagatcgg tgcgggaggg tgagaacgcc cacggcgcaa
     2221 ccgtgttcgt cgaccacggg cgacgatccg agctgccggt accgcatcgc gtgctccgct
     2281 tcgaccagca tggtcacggg cgaggggaac ggtcctgcct cgccgaggac gtcccgcaga
     2341 cggacccggt ccgtgtaggc gcagctgtcg cggacgccag tgagctggga ccgagtgatc
     2401 aggcccgtgc accggccgtc ctcgtcactg accagcaggt gctgcgcacg ggcaccggcc
     2461 atgacggaca gggccacctc caccgtcatg tcgtcccaga cctgcggtcc gggcgcgtcc
     2521 atggcgtcga ccacggtcct tgcggtggaa cgcgccgggc gcggcttcgt ctggaccagc
     2581 gtcaaaagtg cctcctgcgg aagtgggtcg aggtttctgg gcgcggaagt tctaggccgc
     2641 cgcgtcgaag gcggactgcc gctgggccgt gcggcgcgcc gcctggccgg tccggccgtt
     2701 ccttgcggta cggccgcggc gaccacgcga ggcggaggcg ctgcgtcctg ggcgctcggt
     2761 cacgggtgcc gtgatgacga cggggacgcc cgagggagtc cgcgcgccgg tgatgcggct
     2821 cagttcggcc tcgcccgagc ggacctgggt ggtgtgcggg cggatgccgg catcggacat
     2881 caggcgggtc atgccgcggc gctgatcggg cgtcaccagg gtgacgacga gaccggactc
     2941 gccggcgcgc gccgtgcggc ctccgcggtg gatgtagtcc ttgtggtcgc tgggcgggtc
     3001 cacgttgacc acgaggtcga gattgtcgac gtggatcccg cgtgccgcga cattcgtcgc
     3061 caccaggacc gtcacatgcc ccgtcttgaa ctgggccagg gtccgattgc gctgcggctg
     3121 cgactttccg ccgtggaggg cggcggcccg tacaccgctg ttcagcaggt ggccggtgag
     3181 ccggtcgacg gcatgcttgg tgtccaggaa catgatcacc cggccctccc gggccgcgat
     3241 ctccgtcgtc gcccgatgct tgtccgcacc gtgcacatgg agcacgtggt gctccatcgt
     3301 cgtgaccgca cccgcggacg ggtcgacgga gtggaccacc gggtcggaca ggtacctgcg
     3361 gaccagaagg tcgacgtttc ggtccagggt tgccgagaac agcatccgct gccccccggg
     3421 acgtacctgg tccagcagcg ccgtgacctg cggcatgaag cccatgtccg ccatctggtc
     3481 ggcctcgtcc aggacggtga tgtccacctg gtccaggcgg cagtcgcccc gctcgatgag
     3541 gtccttcagc ctgcccggcg tcgcgatgac gacctccgcc ccacctcgca gcgcactggc
     3601 ctgcctgccg atcgacatcc cgccgaccac cgtggccagc cgcaaccgca cggagcgggc
     3661 gtagggagtg agcgcgtcgg tgacctgctg cgccagctcc cgggtgggca ccagcaccag
     3721 ggccagcggc tgccggggct cggcccgccg gccggccgta cgggccagca gcgccaggcc
     3781 gaaggcgagg gtcttgccgg acccggtgcg tccgcggccg agtacgtcac gaaccgcgag
     3841 ggagttcggg agggtcgccg cctggatcgg gaacgggacg gtcacgcctt cggtgacgag
     3901 cgcggccagc aacggccgag gcatgtcgag atcggcgaac gcctcgacgg cgggcagcgc
     3961 gggggtgacc gtcacgggcg gggcgaactc gccctggggc gcggcgggac ggcgcccgta
     4021 gccaccggaa cggcccgccg tgcgggagcg gttggaggcc gaggtgcccg agcggctgcc
     4081 gccctttccg gagtaggaac cggcgttacg ggtgcgggtg gaacggtcgt tcgtacgtgt
     4141 gcggttcatg cagaaccttc ctcgaagcgg cacgtatcaa ggaatttctg ctggatgaac
     4201 ggcgcagaga atcgcaagaa cgggccaaca tgcgaaagca gatcgaccgg cgaggaaatc
     4261 ctcggggtcg gggcgctgaa aatgggtggc gccatccggt gcggagggac cgggcgccga
     4321 gtacggggag ctctggacag actggaggcc cggagcctcg agtggagcat ccgccgtact
     4381 gagaggctgc ggagctctcg aaatcatgtc gccggtgaaa tcgccacggc atgacaaaag
     4441 ggcctgtgcc ctggagtgga acgtagctgg ggcccgcacc caaggtgcgg gccccagcta
     4501 cgactgtgcg cgtcagcgtc aggcgggaac gatgttctcc gccgtcgggc ccttctggcc
     4561 ctgcgcgatg tcgaagctca ccttctggcc ttcgagcagc tcgcggaagc cctgggcggc
     4621 gatgttcgag tagtgggcga acacgtcagc gccgccaccg tcctgctcga tgaagccgaa
     4681 acccttttcc gcgttgaacc acttcacggt gccagtagcc atttttgaat ctccttcggg
     4741 gcagtgcatc ggattccaca ctgtgcggat tccacgtcgc cgcgatgatt gccctgcccg
     4801 ggtaatgacc ggaaatacaa aagcactctc gttggcatcc aaagccgatg agggcgcttg
     4861 aagttctggg aaccacaact gcaactgatc tcgacagtag cacgccgcga tcggctgtgc
     4921 gcggcgcatg atttcgctcc gcctgttgcg tcagaaaacc tcatcaggtg ttgcgtcgat
     4981 ttctcatttc gcggccacag atattggttc gtccggagca cagcgtttgg ctcgaggggc
     5041 ggtgccccgg caatgcggtg cgactcgtcc ggccggcccc ggacccgccg ccggaccggc
     5101 cgccgagggc ctgggagggc gggggccggg cccaccattc acccacggtg tcccaccggt
     5161 ccggctctcg ctgctctggc tgcgcgacag cggccgcgta cgcgaaagcg tcggtccttc
     5221 aggccgcgat cggggcctgg aggaccgacg ctcggcgatg actagcgagc gacccgctcc
     5281 tcggacagga tctgctgccg cagctccacc agtgcccgca gggcaccgct gtacatctgg
     5341 aggctcttct cgctgtgcgt gttcacggcg gtcttgacct cgttgaaggt cttggcgatg
     5401 acctcgtcca ggtcgttcct gtcgatgccg ttcatgttgt ttctccttcg atgggcgtgg
     5461 tcagtcccgg ttgaccggcc acgacgtgat gttctgccag ggaccgcagt ccttgacatc
     5521 ctcagtgccc ttgcacaccg tgagccggcc ggtggtggtg ggccggtacg cctgccgcac
     5581 atggacgtcg acagcgccgg cgccgcacac ctcggcctgc ttcctgagcg gaccaggggc
     5641 gaagtcgttg acgaagcggg tccacacgga gtagcagccc tcaccggtgt tggacagctt
     5701 tccgctgatc accaggtcgc cgggctgctc gatccaccgt tcaccggcag cgccggcgct
     5761 ctcgtgtccg gccgaccacg cgacggtccc ggccggcttg ccgccgtcct cggcggtggc
     5821 cggggtggcg acggcgagca gggcgccgac ggcggccgcc gcggcgaccg gggtgcgagc
     5881 acgcatcaga tcaactcctt cttccgtggg gacaggtcgg gcgcggtccg tatgccgtgg
     5941 tggcggcgaa gcgcggacag ggcggcgaga tggccgcaca tgccgtgcac ggaaggcccg
     6001 ggaggcgtgg acgccgagca caggtacacg ccgggcagcg gggtggtgta cgggtcccgg
     6061 cgcgccgtcg ggcgcgccag cgactggcgc agcgtcatgg caccggcggc gatgtccccg
     6121 ccgacgtagt tggggttgta cgtcgcgtac tgggcggccg agacgccacg ggaggcgatc
     6181 accgtgtcgg tgaagcccgg tgcgtactcc tcgatgcgcc ggcggatcag gtcgaccggg
     6241 tcgcgggtgt cgccgttggg gacgtgggcg taggcccata cgggccgcct tcccccagcg
     6301 gcccgggacg ggtcggtgac ggccgggtcc acgacgagga cgaacgggtc cgggaccggc
     6361 ttgccggcgg ccgtggcggt ttcctggcgg aagatgtccg cccgggtgcc gccgaggtgg
     6421 accgtgccgg cctgccgcac gagcgggtcg acccacggta cggggccgca cacgaggaag
     6481 tcggcctttg ccgctccggg tccgtagcga aagcggcgca gggcacgacg gtagccggag
     6541 ggcagccgct caccggcgat ggccaggagt tccctggggc ccacgtccag caggacgagc
     6601 gggaagtccc cgagctcggc caggtccctg acgcgatgtc cggtgtggaa gacaccgccg
     6661 tgagctgcga tgtcggccgc catggcatcg gcgatgcggg cgctgccgcc ctggggcagg
     6721 ggccagccgc tgctgtgcgc ggtgtgcgcg aggagcatcg cgacggccgc cgacgcgacc
     6781 gaggggagct tgccgacggc gtgcgcggcc acgcccgcca gcagcgccct cgccggctcg
     6841 gtggtgaacg gtgtgcgccc ggtggcgtgg gccagcaccc gccggacgag cagcaggggt
     6901 gtcagaaggt ccgccggcag ggtgcgctgg tcggacagca ggaggtcgac cacggaccgg
     6961 gaccggtcgg ccagcggctg catgagccgg gcccagcgcg ggccgtcggc gcccaggtgg
     7021 tccgcggtgc gggtgacgct gcgccaggcg gccgccgccc gcccgtcggg cagggggtgg
     7081 gcgtacggca tgtcgggctg cagcagccgc actccgcgag cgggcaggtc gaactgccgg
     7141 aagaacgagg aggcggcggc catcgggtgg acggccgagc agatgtcgtg caccacgtcc
     7201 tggtcgaaga gcggctcggt gcgcaggccg cccccgatgg tgtcggccgc ctcgaacagg
     7261 gacacgctca ggccggcccg ggcgagggtc acggcggcgg cgagcccgtt gggcccggtg
     7321 cctacgatcg cggcgttcgt cgtgaggctc atgtggcggc cccggcgggg gcgagctgcc
     7381 ggccggcgag ccgccggtag gtgctgtcac cgtccatcag ctcgtcgtgc gtgcccatgg
     7441 cgcgcaggcg cccgtcctcg atgaccagga tgcggtcggc gccgatggtg gtggacaggc
     7501 ggtgcgcgat ggtgaggacc tggcagcggc cgccgatggt ggtgatggcg tcgcgcaagg
     7561 cagtctccga gtcggagtcg aggttcgagg tggcctcgtc gaggagcagc acatcgggcc
     7621 tggtcagcag ggctcgggcg atggcgaggc gctgccgctg cccgccggac agaccggtgc
     7681 cgccttcgcc gagctcggtg tccaggccgt ccggcagggc ctcgacgacc ttggtcagat
     7741 gggcagcctc caaggcctcc gcaatgtcgg cgtcggtggc gtccgggcgg gcgtacgtga
     7801 ggttctcccg caccgtgccg cgcatcaggg gggagtcctg ctcgacgagg ccgatccggg
     7861 cgcgcagctc gccgagcggc atcgtcgcgg tgtcggctcc ggccaggcgg atcgtgcccc
     7921 ggtcgggggt gaagaagcgc tcgacgagct ggaacagggt ggtcttgccg gcgccggacg
     7981 ggccgacgat cgcggtcacg ccggtggcgg gcagggagaa cgacacgtcg ctcacggccg
     8041 gggccgcggt gtcgccgtag ctgaaggtga cggtctcgaa ctcgaccgcc ggtgccccct
     8101 cgacggtgcc ggggcccatc gcggcaccgg tctcctcctg ctccacggcg gccagttccc
     8161 gcaccctgtc gatggcggca cggccctgct ggaactcccc gagcgccatg aacagcatca
     8221 ccagcggaga caccaggtag aagaggtaca tgatgaacgc cgtcagctgc tcgacaggga
     8281 gggctccggt ggcggtgcgc gccatgcccc acgcgatcac caccgccagt gacacctgcg
     8341 tgccgacgtt catggcgggc atcagcatgg ccgacagccg ggtgacgcgc agcccactgt
     8401 cccgtgcggc gtcggcgaga gtgcgcaggc gctcctcctc gcgctgctcc gcccgggacg
     8461 ccttcaccgt ggtcaacgct cccagcaccc gcagcagtcc ggagccgtag tcgctggtgt
     8521 ccgtccggtt ttccaccgcc gccctgcgga ccgcgcgggc cagcccgagg gctgtcgccg
     8581 aggcggcacc gaggcagccg gccgtggcca gcagcatctg ccagtcgatc cacgccatga
     8641 cggcgatgca gccgacggcc gtgaaccccg aagtgatcat ctgggccacg gacgaggaca
     8701 gcgcgatcct ggcgatcgag gtgtcggcga cggtccgggt gaacacatcg ccgtgctcca
     8761 gcttgttgaa cgcccgtacc tgggcgtgca ggagacggcc ggtgagcgtc gtgcgcatgt
     8821 cgagaacgat gttctccccg gcgcggccga tcagatagaa gtgtgtcgcg gccagagccg
     8881 cgtcggcggc gaacagggcg gcgatgaaca cgatcggcca cagcacgggc cggtccgtcg
     8941 cgacagcctt gatcagatcg ccgatcagca gtggctgtac gagggtggcg ccggtgccca
     9001 cgaggccgag aagggtgccg gcggcgagca gcaggcggtg tcggcggacg atcacggatg
     9061 tgttcaccgg ctgcccttgc cgaagacggc cgcgatgacg gcggcgatgg tcgcggcgaa
     9121 cacgaagccc ttgatccacg agtcccgggt gatcacgccg tcgtcgcgga acatgaccag
     9181 catgctcggt acggcgaagg cgaacgcgat ggcgaaccac gtcagacggt ttgctgtcag
     9241 cactgccggc tcctcccttc tggtgcctac ttggtggcgc gcgccgtgta ccagtcgtac
     9301 ggctgcgggc tctcggccgc gtacacgtgc tcgacggtga atccggcccg gtccaggcag
     9361 ccttcgacct cgtcgcgctc gatgaggagg acgtgttcgc tgaattccac cggcggtttg
     9421 ccggcttcgt cgatgcgggt gcccatggtg aggacgtccc tgtcgtcgag ggtgatggtg
     9481 aaggtggtgg tgccaccgtg gtgcggcgtg ggcatcgtca ccgtgtgctg cgccacgagg
     9541 ggccggtagg tgccggtggc gtagtactcc atggacaggg tcgcgcccgg cgccagtacg
     9601 tcgcgcacgt gggagagggc ggccgtcagc tgttcgcggt cggtcacgca cgccagcgat
     9661 cccatggtgg agtaggccgc gtcgaacggg ccggtgaccg gcagcggcgc tcggaagtcg
     9721 gcctgcacca gcgttgcgtt cccggggacg gtcttggcgc ggaactcgtc cagcatgggc
     9781 cgggagttgt ccaggccgac cacctcggcg gcgatggcgg cgacggggac ggcgacccgg
     9841 ccggtcccga cgccgatctc caggacccgg gcaccggtca catacgggcg cagccggtcg
     9901 acggcggcct cggcgggcag ggcgggtgcg atcagcgagt cgtacacgga cgcgaccgcg
     9961 gtcccgtact gcacgtcccg cccgccctgc gcgggctgcg tcacgggttc acctcttcgt
    10021 agtcgaagac catgtcgtac ttggggtcct cgctgtggtc gtagccggag tagcgcacca
    10081 gcagcacctg gaacagcggg aatccgggct caggggtgag gcgccggcgg acgaattcgt
    10141 tgacgagcag gtacgcggac tccttggcct ccttgtgcag tggggtcatc gcacccgggt
    10201 tgttcagcag ggtggaggcc acgtcgaaga tggccttctc ggcgcggcgg ccggggaacc
    10261 agaaggcgtg gatcagcttg cgtggcgcga tggagtacac ctcccgccac tcggtgtgct
    10321 ccgtcttgtc ctcattggcg agccggtaga ggaagtgctg atcctccacg gccgggttgg
    10381 gcgcgaagaa acgccagttg gggatgagga tcccggtgcc cgtcttgtcg ccgcttcgga
    10441 ccttgtcgta gctgcggtcg ggatgctggc ccaggacgga cgccacgaac cagcccgcga
    10501 ggatcgccgg taccgcccgc tccatcaccg tggacgttct gctcacgccg tggccccctg
    10561 ctcctgccgg tcttctccgg cgtactgcgc cgcggccgcc gccacggcgt cctcgatcgc
    10621 cctggtggtg agcggggcat gctcgacacc gcccgtgatg gacagatggc tggagccggg
    10681 gatggtcacg atccggcccc cgttgcccga cgcgacgtac tcgtcgtaca ggtcctggtg
    10741 ttcgggggtg tcccgcatcg tcgaatcggc tgccaccacg gagacgggga tccgcagccg
    10801 gtcaaggggg cgcccgccgt cgagcatgaa ggcgtacgag tagtcccact cccgtcgccc
    10861 ggcgcgccat gtggaggggg cggagccctc caggcgcagc gtccgcaggt gcgggcttcc
    10921 ctccgcgaag gagaacaggc ccttcttgtc gatgagcaga ccggtcccga acaccgacga
    10981 ccacggtccg agcttcatcg tcaggttcac gccacgggag ccctcgcgct gtctgcggga
    11041 gtgcagcaac tcgcggggat gggtggggtc gacgagtacg agtccgtgga cccggtcggg
    11101 ggcggcggca gccgcgcggt gggcgaggta gccgccgagg gagtgccccg tcagcacgca
    11161 cgggccgtcg gtggggacgg cgtcggcgat gacttccacc aggtcgttca cggactcccc
    11221 gagcgaatag tcctccgggc agcgccgcag cgacgtgcgg tatccggccc ggtcgtggag
    11281 gaccaccgag atcgccgggt cgaggtggtc ggcgaccagc agccaagccg ctgacgagtt
    11341 catcagaccg gcgtcgcaca ccagcgtcgg accgcccgcc gcgccacgcc ggacgtggta
    11401 cgtgatgagg ttgccgctgt cgcagcgcag gcggtgccgc tcgaagcccg cgtggccgga
    11461 ccgggtggcg agggtggcgt aaccctggtg ggcgagcccg gcggccaggc acgcggccat
    11521 gcccgcggtg gtgagtttcg ggaacgtcat ccggctcatg ccgcctcccc cgtgcccttc
    11581 gcgagtgccc tgacggacgg ataggtggac gcgaacgccc acgcgaagcg ggacaggccc
    11641 atgaagcggg cgttggccac atggaaggtg cccatgacca ggagtccggc gtcgatgtac
    11701 ttgcccttct tgaggagcag cagcgggaaa ccgcactcca gggcgagcac ggtgtggcag
    11761 accgcgcggg acacggccgg gtacttctcc aactggttgt agaaccactc gtcgccgtac
    11821 gtctgggtgc gcatgatctt cgcgagggcg tcgccggacc gccaggcgtc tccgggaagt
    11881 ttggcccagc cggacgcccc gtaggacagg acggtctggg cgccgatgaa ctgcacggcg
    11941 gcgttgcggg tggcgtcggt gccgccggcc cggccgaggg cggcggcggt ctgcaccagg
    12001 aaggacacct gatcggaacc gtcggtgccg aacaagtgcc gtgggtagat gagaagctga
    12061 ctgcccgcca gataggcgtt ggcgaccatc cgcaccttgt tgttcttcac cggtgagatg
    12121 agcacggcgg ccgccagggc acgggacgtg tgaagaacct gggtgaccgg ttcgcgggcg
    12181 atgaagtcct tcacggcctg catcgtcctg gtcttggcgg gaacttgggc cctggtgtgg
    12241 gtccagtcgt tcaggccgcc cggttcccgg tcggtccggc gcacgatgta ctcgaggctg
    12301 gacagcagat gagtggcggc ggacagccgc tcggcggtgg tgagcggctt cgcgcacgcc
    12361 gactcagcgg ctctgcggag acgtgacagc atgatctgtt cctggtcgca tgtcggttga
    12421 ggtggcgagg gggcgtgagg tgccgtgggc ggcgaaaggc cgaggcggga aaccccgaac
    12481 tgctggaggc ttcccgccgg cgaccgctac ttctggcagg ccttgaccgc agcgccgacg
    12541 cccgcggcgg cggtgatgac ggcggagacc ttgccgccgg ccacaacgcc ggccacgaac
    12601 gcggcggggg tcgccatcac gggagcgatc gagccgtcgg ccgcgtggcc ggcgcctgcg
    12661 ttgaccttct caacgagcac ggacatggtg catcctccaa taatctgata cacgggacag
    12721 gctccggttc tggcagacac ttgcactgtc tgccagaacc ggactccccg gaaccgggga
    12781 cccccggact cagccggtgg ccgtcttgta cgccgcgtag gcagcgccgg taacagcacc
    12841 ggcacccacg acggcaccgg cggccttggc gatcacgggg gtcgcgaaga tggccggagt
    12901 ggccatgacg ggagccgtgc cgcgagcggg cgcgcccgcc gtgagcgccc ccttgaggga
    12961 cgcgtcggcg ttcaccttgt gcgtcagcat gtgttttcct cctctccttt gaatgtcggg
    13021 gcagggaaca tcccaccacc gcgcggatgc ccggcgtcgg gaattctgat gtagagaaat
    13081 cgccacttgt tcgtcgagaa atgcgatgtt ctcgaccgag gcaaggtcgg ctcgaaatga
    13141 atatccggga cgatgctcgc cgtgaaaagg gaaaccatgg ggcgcgcgtc aggcggggct
    13201 ttgggccgat gacgaattta cttcgacttt accgtggctc gtgccgactg tgaagaatcg
    13261 gtgtgcgtgc gcgggtgtgg ccacagcggc caatggccga cgccgagggg cgctacttga
    13321 ccttggtggc catgtatgcg gcggccgcgg cgcctgcgct cacgccgacc ttgacggccg
    13381 cgggcgtgaa gatggccgga gtggccatga tgggcgcgat gcgcgcctcg gggccgcgct
    13441 cggcaacgaa atcctcgagc gagacgtcct gattcacctt gttcagaaac atgagcttcc
    13501 ccgttgtttg cgatcacgtg gactgcgcgg acggccagga ggggcctgcc tggagggcgg
    13561 gcgacgcaac gtcgggtgtc cgcggcacca ggcggagggt ggtcattccc tgcgccggtg
    13621 aacgtgccgt cagtatatga acgactggat ccacttgatc aagtaattac ctatgtgatc
    13681 ggcgtcacag tgtgattact ttcgcggaat ttgaggttcc gattgcgctg ggccactttc
    13741 acggaatcta caattccgtg cctcgcctcg cgctgttcgc gcatgaaagg atcgaaccgc
    13801 ccctacctat tgattcgagg aaggatgcat gactccagag gaaagcagtc atattcatgc
    13861 cgagggcgta tggcgccgat acgggcgggg gaagaacgcg ttcgacgccg tacgcggagt
    13921 cagcttcacc gtccggcccg ggcagctgtt cgctctcctc ggaaccaacg gcgccggcaa
    13981 gacctccacc gtcgaactcc tcgagggcct cgccgccccg caccgcggac gcatccgtct
    14041 gttcggagga ctcgacccgg tcgccgaccg cggccgtatc cggccccgca ccggggtgat
    14101 gctgcaggag ggcggcttca tatcccatct gacggtggcg gaaagcgtgg agatgtggac
    14161 ccggctcacc tcccggtccc gccccgtcgc cgaggccgtc gaactcgccg ggctgcccca
    14221 ccgcgccgac gtgatggtgc agaacctctc gggcggcgag aggcgccgtc tcgacctggc
    14281 cgtcgccact ctgtcgcggc ccgacgtgct gttcctcgac gagccgacgg ccggcatgga
    14341 cgccgagggc cgccacgcga cctggcggct cgtcaggagc ctccaggaac agggcacgac
    14401 gatcctgctg accacgcact acctggaaga ggccgagtcc ctcgcggacg agttggcgat
    14461 catgcacagg ggacggatcg ccgtctccgg caccgtctcg gagatcgtcg ccggccactc
    14521 gtcgacgttg tcgttcggtc tgcctgacaa gtggaccgtc cacgatctgc ctgtcagcgg
    14581 cagggtggag cagcggggcg gacgggtgac cgtcacgacc gggcagttgc agcaggacgc
    14641 cggccggctc ctcgcctggg ccgagcgcca tgacgtgacg ctggaccggt tcaccgcgcg
    14701 gccggcctcc ctcgaagagg ccttcatcag catcgcgagc caggaaggga ctgcggagtg
    14761 aacggtctgg ccatgcggca catgaaggcc ttgttccgta tcgagtggaa gttgttcaac
    14821 cggatcaagg cgaactacat cttcgtgctg ttcgtgccgt tgatgctcct ggtgtcgatg
    14881 cggttcgtgc aggaccagat ggagctcgac aagcacggcc tgaacccggg cccgctgatg
    14941 gtgtcgaccg ccgtcggcat tctgttgatc ttctccctgt actcgtccgt caccggactg
    15001 tacgtggcgc gcagagagga gctcgtgctc aagcggctgc gtacgggaga ggtgtccgac
    15061 ccggtgatcc tcgccggcgg cgcgtcgatg tacatcgcga tcgccgtggt gcagatcgtg
    15121 tcggtcgcgg tcgtgctgtc ggtgatgttc ggtgtggcac cccggcaacc gctggccgcg
    15181 gtcgccgggt tgctcacggg agtggtgctg atgacggcaa tggcggccgc gacggccgca
    15241 ctgtgccgca ccgtcgagtc cgtgttggtc gccacgctcc cggccatctt cgtcctgccg
    15301 atgatctccg ggatctacat cccccgcgag gtgttgcccg aggcactcgg cgacgcgttg
    15361 ttgttcgcgc cgctgtcccc gacggtcgat ctggtgcgct ccgggtggac cggcgagctg
    15421 acagcggccg gcgcgtcgat cagaggactg ctggcgatcg cgtggacggc tctcttcgcg
    15481 tggctcgcgg cccgcagatt ccgctgggag ccccgcacct gacgccggcg gtcgtcacga
    15541 agcggcactg caaccggaca gggcggcggc ctcgactgcg tcgcccgccg taccccgccc
    15601 cggcggctga atcgttgatc catgcggcca tggacgggag gtaacgctcc agggctgggg
    15661 cacgcgggac cggaggtggg ttcgcggccg gtccggtgga cggtcgtacg acctggacgt
    15721 gcgtgtcgtt cggcgaacgg gttgcgaacc gtgcacggca gctgatgtcg gacggccggc
    15781 aacggggtcg ggagccgcgg ccctgcgcgc catcggctcc gtcgacgacg ggggcggttg
    15841 tcggcctact ccaggacggc gaggtggtcg gcggcgcccc cgcgccactc gatcaggaag
    15901 agggtcgcgt cgtcactggt gctcccgccc cgttcctcct tcagcgtgtg ggagagcgag
    15961 cgcaccactg cccgcactcc ctcctctgcg tgctcgatgc ggttgaccca gtggatgagt
    16021 tgttccacgc cgaactgctc ctcgccggct tcgtgctcct cgatcaggcc gtccgtgaag
    16081 cacagcaccc ggtcgccgcg ttggagtgtc tgctcgctga cctggggctc ttcacctccg
    16141 aatccgacgg gaaaagtggt cgggctctcc agccgccgga tgacccggtg tttgcggatc
    16201 atcagcggtg cggggtgccc cgcgttgacc cactgcaggt ggcccgttgt gatgttcaga
    16261 cgcatcatct gcgcggtgac gaagtgttcg ggcccgaact ggtcggcgat ggcccgatcc
    16321 atgaacgtgt agatctcggc caggtcgata ccggcacgtc tggaatgccg gtaagcgccg
    16381 atggcgacgg tggccatcgt ggcggcgttc aggccgtggc ccatcgcatc aatcacggcc
    16441 acgtgcagga tgtcgtcgtt gagcgcgtag tcgaagctgt cgccggcgac gtggtaggcg
    16501 ggctccagga ttccggccac cgcgacctgc ggcacggaca tcgccagcgg cggaagcaga
    16561 gaccattgga tctccgcggc cacgctcatg ggttcacggc gccgggtgag gaagaactgg
    16621 tcggtgtagc tgtgcttggt gaccagcatg tcggcgatca gtccggcgag cctgcgcagc
    16681 aggcgccggt cgtcgtcatc gacggtctcc atggtgacgg ccagcactcc cacctggtcg
    16741 ctgccgtcca gcaacggcag atacatccgg atgccgtcgg cctgcggtac ctcgacaggg
    16801 atcgcacgca ggaaggcggt gccggcgtgg gagtcaccga tcggctcggg ctcgctgacg
    16861 gccagccgcc tacccggcag cggcaccagc agcagctgtg catagtcctg caggaggatc
    16921 gagatgtccc ggccaccgac ccgggccacc tcttccgcga tcagcggggc gatcagctgc
    16981 ggcggcatct cgtgtgcccg gtccagcagc acccccagca gccgctcacc gaacccctcc
    17041 gaccggtcca ccgagtcctt gccaggctgc cgatcaccct ccgccataac cgtgcccttt
    17101 cacctcgccg gcctggtttc gtttcacctg tcgagtcagc ggtctccaac gagtgggtca
    17161 cagggcgcag tggtgcttgg cttcgatgca tcgctcggcc gccatacgcg cgaggatcgg
    17221 cttgttccct gccgtcgcgc cgaccgtgcg caacgacccc ggcgtataca caccggggtc
    17281 gcccttccgg gcggttgcac gtgagagtgc accgacccgt tcaccatgct atgcctgtgc
    17341 cgcttatccg gcatgaggaa ctttttgtgc attgcggtcc ttgatcggaa aggctcagcg
    17401 ccgcgtcagc ggggttcctc ctcttcggcc tccatgaacc ggattccctg atgcgtcagc
    17461 gtgaccatcg caggtgtatt tccccgtgcc cagtcgaccg tgatgagccc ctcgcccgcc
    17521 agatacgtgc aggccgcggc cagatcctgc tcgggcatgt ggaggtcgtc gcgcagtttc
    17581 gccccggcga cgccaaggag gcgattgcct tccgtggcct cgtacagggt cctcatgatc
    17641 gcttcgcggt agttcttccg ctcgtggagt gttgccatga ttgccgtcca ctcgggccgg
    17701 gcaccggccg agggcccttg cctcagactt cgtccgtctg tgtgcggtcc tgatcggagg
    17761 accgactggc tgccagccag ggccgcgcca gccgtggtgt gtgcgtggtg tccacagtca
    17821 ggtggaggcg ggttccgcct tcgctgccgg cggggtagct gcgctgttcg gtggcggcga
    17881 agcaatgacg aagtacctct gcgacccgac gggcggtctc gggggacgcc gcgacgatac
    17941 gcacctctgc gcgcccgtcc gcaggtggtt ccggtggctt catggtggcc tcgttcatca
    18001 ggtcgacgtg ccggtgggcg ggcgctgcag cgccacaccc atcgccccgg tcaggagaag
    18061 gtcatgcgtc atccgcggcc ccctctcggt cttccctgtg agcagaggcg acggggcgag
    18121 cggggacgac gggcgatccg gcgtgctctg cccgctgtcg gctcttccgg ccccgccgac
    18181 cgattccagg caaggcatcg ccgtagtgga atgccgcgat ccgctcgtgg tgctggccgt
    18241 tgagcagatg gatcaacagc actcctatgg tgatcatcgc gaagatcacg gacagggtga
    18301 tggcggtctc catgtcctca cctccctcgg accgagctca tgggcccggt cggattgggc
    18361 tgctcgcccg ccgctgaagc gtgcccgccg tcggtctccc actccacttc ccgggccagg
    18421 gcgtccctgg catcacgggc gatgtcctcg ctcgccatca gaccgctggc ggcggcgagc
    18481 ccgcccgcgg cggccgcggc ggccatcagc cggccggcgg cagcctcacc ggtctccggc
    18541 gggatcacca gcagatccca gcggcctgcg gtgtaggaaa gaaggatcag cttgtgcggg
    18601 tcctgctcgt cggtgaacca gcccacgtgc accgtgtgcc cggccacggc caccttgcgc
    18661 gggatcacgg gccagtgggt cgggttcacc gtcacacgcg tgatccggcc ccagcacgcg
    18721 tccagcacct cgacaaggga ggggagttca cgggaaagat cgcgggagcg aggccaccag
    18781 gcaccgtcca gcagacctgg aaccgacccc gccggggtca gtgacaggcg tgccggtggc
    18841 gaggccacgc gcccactgat ggtcatacgg tcgatgatcg cggtcatggc gcggacctgt
    18901 ccccgggcgc atcgtcacag tcccggtgtt gctgctcgcc gagaacgaca cccgcgtggg
    18961 agccggtgtg cgaagtactc ccggtgtctc caatgtactc cgggcacgat ccggtgaacc
    19021 cgcgtgtgac cagcgacttc catgggaacc cacttttgga tccgcggccc gcagccctca
    19081 ggcgaacgcg gacgtcggct gacggagtac ggtgaaatcg gcagcccccg gacgccatcc
    19141 caggcgatca acgaaggcat accgaccccc gcagacgggt gagcacacca tgtccgacgc
    19201 cgacaccccg cgtgaaacga agctcttgcc ggactcgatc cacgaggccg tgaaacctgg
    19261 aacagcactt ctgcggctgg agacgacaca tgtccgggag ggaatcctcg acggcgcatg
    19321 gtggccgcgt tcccgcgaca tcggcgccga attgcccagc ctgatctccg cgctgaccga
    19381 gcatctcgga cctgtcaccc gcgtcggcct cgactccagt gcctgggaag aactaccgac
    19441 acgactgatc atcgacgacc gcgtcgtgca catcgactcc ttcccggtcg gtgacgacac
    19501 cgtcctcatc acccgaggcg atcgggacca cttctcactg ctggtgatac cgcctcacgc
    19561 gacacccgac gcggcacgcg cggcgatggc ccgggccgtc gtcgccgaca gtgccacggc
    19621 cgagcagatc ctcatcgaca ccggcaccgg ccggacacac ccggtcgcca cggaggatcc
    19681 ccggacaggc aaggaacgca gcgatatgag gtgatgcaga tggttgtctt tctcctgctg
    19741 atcatcgtgg cgatcgtgct gggcctcatc ggagcggtgg tcgaggggct gttctacctg
    19801 ctcatcatcg gcgtgatggt gctcgttgcc gacctggtcc tcctccgtat acgcgtgggc
    19861 cgccggcagg caccgaaacg ccgcctccgg taaccggtgg ctgatgctcc acgacagggc
    19921 ggcgaaagat cccgcatctg gaccgcctgc ggtgcccagg tcatggacca ggtcatgaat
    19981 ggagggctgg tgccgggctc gcatggtggc cgagggggag ctgagcggtc cgcttccccg
    20041 tcgtcgagcg ggtgacggtg actcgaaccc gcgctccgag cctcggaata acaaggtcgt
    20101 cacggatcgt ccgcggccgc tggtctgcgc ataggctcca cacagcttgc ggctgtcact
    20161 gcgcttgagt tgtcggcgaa ccaatcccca cggcctcacc acccgtgacg tgaggtgtcg
    20221 ttagaggtaa cgtgcgccgt acacttttca gcctgctggc cgatatgcaa ccagggactg
    20281 tgatgcagga acgtttgatg ttgcccgctc atgcccacca ggagacggtg tccgcctacc
    20341 cccaggcgtg gcatgtccct gacaccatgg gtgggcgcgg caaggcagtt gagcgccaca
    20401 tggtgcttct cgcggtgttg cctgccgtgc tggtcacgat caccggagcc gcagccgctg
    20461 ctctcctgtt caccgcaggc gtgggccacg tcgacaagag cgccttctgg ggtctgttca
    20521 atggcacgct gctgctggtc tgcatg
//
