LOCUS       NZ_BMWB01000015        22540 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence15, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000015
VERSION     NZ_BMWB01000015.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 191599)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 44135
            Orig. end                         :: 66675
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22540
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22540
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22540
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12540](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12540)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(350..360)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(1045..>1149)
                     /locus_tag="IE198_RS21445"
                     /pseudo=""
     CDS             complement(1045..>1149)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004926540.1"
                     /locus_tag="IE198_RS21445"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="RTVMVTHDSAPARRAERVATIRKGRVTVKQQTRL"
     misc_feature    1198..1212
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    1266..1275
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.08"
                     /tool="antismash"
     misc_feature    complement(1266..1279)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.46"
                     /tool="antismash"
     misc_feature    complement(1266..1280)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.56"
                     /tool="antismash"
     misc_feature    1267..1280
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    1267..1281
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.4"
                     /tool="antismash"
     misc_feature    complement(1268..1281)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.54"
                     /tool="antismash"
     misc_feature    complement(1269..1282)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            1320..1928
                     /locus_tag="IE198_RS21450"
                     /old_locus_tag="GCM10010381_43440"
     CDS             1320..1928
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315759.1"
                     /locus_tag="IE198_RS21450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43440"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_189889036.1"
                     /transl_table=11
                     /translation="MTDQDLPHEHRARVLDPREDAAALKALTHPLRIRMLGMLRMDGPA
                     TASELAVRTGESSASTSYHLRVLAKYAFIEEAEHRDGRERRWKAVHEVTSWSNAAMAGS
                     VEARAFVDVSRRAQLDHLERSLARHQEDLAAGRLGGEWLEPSGFTDLVVRLTPEALTEL
                     RETFNRTVTELAARDKDDPRAEQVVLFAAGLAVHAEDRS"
     gene            1925..3262
                     /locus_tag="IE198_RS21455"
                     /old_locus_tag="GCM10010381_43450"
     CDS             1925..3262
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455952.1"
                     /locus_tag="IE198_RS21455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43450"
                     /product="MFS transporter"
                     /protein_id="WP_229834183.1"
                     /transl_table=11
                     /translation="MKRQLDPRAARHRFVAVTFLFWLPVGLYIPSQVLLLTERGMSLAV
                     VAGLFAVHSVTVSLMELPTGGLSDVVGRRSVLAAAGLLNLSALTMMALGTTVWALAVAM
                     FLMGSGRALSSGPAEAWYVDTVQAHSGLAAELRTGLARGGTAAAAALALGTLVGGALPL
                     LLSLGADPVAWPADVTGGLVLPLSVPGLLGAAVGVGYVAYVLTALPEPPRAPATLRGVL
                     RGVPATMLDGLRLGVTESLVRRVLLTSAAAGAALAAIELLTPGRAARLTGAPESGAVLY
                     ASLACAGFLCTAVGSHCAPLAARLTGSGEHAVLAALGVGSTGLVLLGVTAAWDGGPAPS
                     AVAAVGYGLVYLGLGAAGPNENDLLHHRVDSTVRATALSVKSLALQSVAALTGLVAGFL
                     PVGPLPWLVGAAALLVGALLWTRRTRPTAVPVAGGPLPATESLPGR"
     gene            3272..4858
                     /locus_tag="IE198_RS21460"
                     /old_locus_tag="GCM10010381_43460"
     CDS             3272..4858
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129628.1"
                     /locus_tag="IE198_RS21460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43460"
                     /product="serine hydrolase"
                     /protein_id="WP_189889038.1"
                     /transl_table=11
                     /translation="MVLQRRVGHRRRRAPAVTLLASVLVATGATAAGAAEPPPPPPPQL
                     TDKQVNDAVAKLDGIVRDGMEKTGVPGVAVAVVHKDRVVHTKGFGERETGKPGPVSPDT
                     VFQLASLSKPLASTVVAGAVGDKAIGWDDPVAKHVPGFALKDPWVTEHVTVADLFSHRS
                     GLPDHGGDLLEDLGYDRDYILSHLRHLPLAPFRASYAYTNFGLTAAAMAVAEAKNTSWE
                     KLAEDTLYAPAGMNSTSSRFDDYEKAGNKAVTHVKEGDAWQAKYVRDADAQSPAGGVSS
                     TAEDMATWMRLQLANGRLGDERIVPAGPLTRTHWPESVAQPPAGPADRTGFYGLGWNVG
                     YDDQGRLRLSHSGAFGLGANTNVTMLPAEQLGIVVLTNGEPVGLADSIAFNFYDTAQYG
                     KPTGDWLTRIGQVYEQEEQEARSPTDYARQPSGAADAQPVDTYTGTYRNDYYGALRVTA
                     TNGGLTMELGPKPLRFPLTHYDGNTFSFVTVGENAVGRSGVMFTVDSGGKASKVRVESL
                     DETGLGTFTRE"
     misc_feature    complement(4947..4961)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.84"
                     /tool="antismash"
     misc_feature    complement(4949..4965)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.8"
                     /tool="antismash"
     gene            4967..6772
                     /locus_tag="IE198_RS21465"
                     /old_locus_tag="GCM10010381_43470"
     CDS             4967..6772
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974469.1"
                     /locus_tag="IE198_RS21465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43470"
                     /product="serine/threonine protein kinase"
                     /protein_id="WP_229834184.1"
                     /sec_met_domain="Pkinase (E-value: 1e-38, bitscore: 126.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 4.6e-07, bitscore: 23.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGSGATPREPGDPRRIGAFTLLGVLGAGGMGRVYLGTASGRYAA
                     VKQVLPILAEDRDFLRHFGHELDNLARLPAGASAALLAGDRTAQPPWFATEYIPGITLN
                     DAVRVNGGPLTGNALWLLLREAASGLRRVHATGMVHRDLKPSNVMLTTDSLTLIDFGVA
                     RAADQSRLTRTGMVIGTPAYMAPEQAVAERRLTGAADVFALGSLMLYAANGRPPFGDGS
                     GPGLLYRIVHTEPDVGTLPDTDPELFDVVKSCLAKSPADRPTAGELLDLADERTTAEAE
                     ATWEWPSPVAERIAERVAFAATPPTVAAEPEEPEEPEEEPRKAEPESPPATTGAKKKRR
                     IRVPLVIVIPIVVGVGTTLTLALAPFESTPEAKGPGANSAPPTPTGSPPASPSNTPSPN
                     ASLSPSGSPSPGTTTAGPAPGVPAPGPAQGGGGGSDATGGTDPGGDSGGSGGGTNTPGG
                     GQAPKPPEPDTPQGNQRLTNSANGKCLAEHINGGLVQAAPSTCGAPSSNGGQINYDWNL
                     SGSGGTFRLVSGSGRCLAADTNNFVMSLDSCSGSSDQLWRIGSTTSAGSTLKNASTDRC
                     LAMSDTNVITSGCNTSDASQLWRGL"
     gene            complement(6774..7445)
                     /locus_tag="IE198_RS21470"
                     /old_locus_tag="GCM10010381_43480"
     CDS             complement(6774..7445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038952.1"
                     /locus_tag="IE198_RS21470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43480"
                     /product="hypothetical protein"
                     /protein_id="WP_229834185.1"
                     /transl_table=11
                     /translation="MNSIRQYHDPEVWRAQKTRAWVALGASFLILAAYGTEADWNEVQE
                     QYFIRLVITPWLLMLTVPLVLLVLFRLAPPSARPGMRARLRPAVRSVLWYFGAFTSVPV
                     LYTGVMLLSESYANSRLSPLITLALLLPALWVLFFVVFASTTVVRTAFSTADVHAALPA
                     LLTGVLVWELAAINLATAGMPPGPPIVQVCAVVGGPASVTAIAWWELTRLRTRYGVTLR
                     G"
     misc_feature    complement(7972..7985)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.78"
                     /tool="antismash"
     gene            8286..9515
                     /locus_tag="IE198_RS21475"
                     /old_locus_tag="GCM10010381_43490"
     CDS             8286..9515
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977368.1"
                     /locus_tag="IE198_RS21475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43490"
                     /product="MFS transporter"
                     /protein_id="WP_189889044.1"
                     /transl_table=11
                     /translation="MLTVSSCPLGPRTSGVRSLERKLYAYAGLEDFVLLYPLYALLFAE
                     HGLTTAEISSLFAIWCVVGLLVEVPSGVWADVVSRKALMVIGPVLTAGGFALWALTPSY
                     AAYAGGFTLWAIGGSLRSGSMEALVHDELERLGAADRYGRVMGRAAAVSMAATATATAA
                     AAPALAFGGETLVWGGSIAACLLCAAVGATLPEHRATGHHGKARRPGCIATLRDGLDEV
                     RGSRPVRRAMVLAVVITSVWGVLDEYVPLLAASTGVATQTVPLLVLVVWVGVTLGSLLV
                     GPGERLTDRTAATLVAVAAVALAAGALSGTLAGFVLLGAAFGVFQLADVLADVRLQAAI
                     NGPSRATITSLTGLGTNIASLLAYGAYAALSPHASHGAVFALLGLPYLLVAGALGRPRP
                     APAPAGQEAQ"
     gene            complement(10001..10447)
                     /locus_tag="IE198_RS21480"
                     /old_locus_tag="GCM10010381_43510"
     CDS             complement(10001..10447)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604204.1"
                     /locus_tag="IE198_RS21480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43510"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_229834188.1"
                     /sec_met_domain="PF13471 (E-value: 5.9e-24, bitscore: 78.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSITVALDRDRARRPLKLRLLTRLAICAARLLVLLKPHLLTRVLT
                     RLSRNAAAADSAQANAARDSVLAAGLSLNGLRSCLPRSVSIALLCRLQGVWPTWCVGVR
                     AAPPFAAHAWVEVDGELIGERGRSDSLARLITVAPAKGRTPGRS"
     gene            complement(10444..10701)
                     /locus_tag="IE198_RS21485"
                     /old_locus_tag="GCM10010381_43520"
     CDS             complement(10444..10701)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460374.1"
                     /locus_tag="IE198_RS21485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43520"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_189889046.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3e-23,
                     bitscore: 75.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-16, bitscore: 52.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRNRPYLTVTETEYGAVLLDTKTGEYWQMNPSAATAAQALLDG
                     GDADDAVRRVTDHFEVDTERAANDVRALIEAMWSAGVVQE"
     aSDomain        complement(10450..10695)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE198_RS21485_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="4.40E-24"
                     /identifier="RREFam002.1"
                     /label="IE198_RS21485"
                     /locus_tag="IE198_RS21485"
                     /protein_end="84"
                     /protein_start="2"
                     /score="75.3"
                     /tool="antismash"
                     /translation="LRNRPYLTVTETEYGAVLLDTKTGEYWQMNPSAATAAQALLDGGD
                     ADDAVRRVTDHFEVDTERAANDVRALIEAMWSAGVVQ"
     gene            complement(10729..12540)
                     /locus_tag="IE198_RS21490"
                     /old_locus_tag="GCM10010381_43530"
     CDS             complement(10729..12540)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="IE198_RS21490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43530"
                     /product="asparagine synthase"
                     /protein_id="WP_189889048.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.3e-34, bitscore:
                     112.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHGAPHFFALPDREEAGAVARRLHGAAPGLRVLHHPSGRPWII
                     GEWADEDIAVARAGTDAVALIGMLPKRTGELSRRAGRLHGRAARLEGLSSAIPGSFHVV
                     GSVGGALYVQGTAYGMRRVHHAVVDGCPVAGDRAVALADVAGAEVDLTSVALRLPEPLA
                     VQLPPRPMWRGVTDVAPGAYLLAPADGAPPRHVLWHSPPVPERTKAQGAADVREALAAA
                     VAVRTARDGLLSADLSGGLDSTSLCAIAAGQLGPGELIVGGIPGDESVNDDAHYARLAS
                     ASWPHVEHMELTPEQTPLFYQGILDDGCRTDIPAGVAMSRDRATAVISVMARRGSRLHM
                     TGHGGDHLFFQSGAYCHDLIARRPLLAFQRIRGYRTLYGWRWRPVLRQLADRRSYRRAV
                     AATDLTAPGDLGFSTPQLAYVAPPVVQSWLTPECRELVAAGLREAARHAEPYAPTLGRH
                     RELSALYSGTQECAAIAEAGRRAGVPVTMPYFDDAVVDAALSVRPEERADPWQYKPVLK
                     EAVRGILPEQCRARTTKFEGTVDAVGGLYRHRDKIRALWEDSALAKAGLIDAGALARLT
                     ERPGTPDLKNGAVDSTIICEAWLRAVA"
     gene            complement(12562..12678)
                     /locus_tag="IE198_RS35435"
     CDS             complement(12562..12678)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.4"
                     /locus_tag="IE198_RS35435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_229834189.1"
                     /transl_table=11
                     /translation="MTKKAFYETPEFVSAGSFRGATGFLVFFGNDGTGRGWL"
     misc_feature    12828..12843
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(12948..14570)
                     /gene="groL"
                     /locus_tag="IE198_RS21495"
                     /old_locus_tag="GCM10010381_43540"
     CDS             complement(12948..14570)
                     /GO_function="GO:0140662 - ATP-dependent protein folding
                     chaperone [Evidence IEA]"
                     /GO_process="GO:0042026 - protein refolding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133870.1"
                     /locus_tag="IE198_RS21495"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; 60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43540"
                     /product="chaperonin GroEL"
                     /protein_id="WP_189889050.1"
                     /transl_table=11
                     /translation="MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGA
                     PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR
                     NVAAGANPMALKRGIERAVEAVSGALLEQAKDVETKEQIASTASISAADTQIGELIAEA
                     MDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVN
                     SKVGNVKDLLPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGD
                     RRKAMLNDIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGESDQV
                     AGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR
                     NAKAAVEEGIVAGGGVALLQASSVFEKLELQGDEATGANAVKLALEAPLKQIAVNGGLE
                     GGVIVEKVRNLPVGHGLNAATGEYVDMIAEGIIDPAKVTRSALQNAASIAALFLTTEAV
                     IADKPEKASAPAGGGMPGGDMDF"
     misc_feature    14724..14739
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(14727..14742)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            complement(14937..15140)
                     /locus_tag="IE198_RS21500"
                     /old_locus_tag="GCM10010381_43550"
     CDS             complement(14937..15140)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035246.1"
                     /locus_tag="IE198_RS21500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43550"
                     /product="cold-shock protein"
                     /protein_id="WP_005315736.1"
                     /transl_table=11
                     /translation="MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQ
                     RVEFEISQGQKGPQADMVKLAV"
     gene            complement(15552..15827)
                     /locus_tag="IE198_RS21505"
                     /old_locus_tag="GCM10010381_43560"
     CDS             complement(15552..15827)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985363.1"
                     /locus_tag="IE198_RS21505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43560"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_189889052.1"
                     /transl_table=11
                     /translation="MSVNVRIPTILRTYTGGRAEVTAEGATLAEVIADLEKNHTGIAAR
                     VLDDQGKLRRFVNVYVNDDDVRFEQGLETATPEGAGVSIIPAVAGG"
     gene            complement(15863..17164)
                     /gene="thrC"
                     /locus_tag="IE198_RS21510"
                     /old_locus_tag="GCM10010381_43570"
     CDS             complement(15863..17164)
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643488.1"
                     /locus_tag="IE198_RS21510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43570"
                     /product="threonine synthase"
                     /protein_id="WP_189889054.1"
                     /sec_met_domain="PALP (E-value: 5.5e-64, bitscore: 209.9,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAQTVASTSTSATTTPVDLGPAAALSCRECGQRFELGPIFACAE
                     CFGPLEVAYDLPSGSPEELRKRIEAGPANIWRYAPLLPVPADVADKPNLNPGWTKLVKA
                     DNLARELGVTGSLFIKDDSGNPTHSFKDRVVAQALEAARAFGYTTLSCSSTGNLAGAVG
                     AAAARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGW
                     GFVNVNLRPYYAEGSKTLAYEICEQLGWQLPDQLVVPIASGSQLTKIDKGLQELIKLGL
                     VEDKPYKIFGAQAEGCSPVSTAFKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARR
                     TGGAVEDVNDEQVVDAIKLLARTEGIFAETAGGVTVGVTKKLIEAGVLDPALTTVVLNT
                     GDGLKTLDAVADTSQATAVIRPSLDAFRAAGLAG"
     regulatory      complement(17182..17309)
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17417..17437)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.9"
                     /tool="antismash"
     gene            17483..18451
                     /locus_tag="IE198_RS21515"
                     /old_locus_tag="GCM10010381_43580"
     CDS             17483..18451
                     /EC_number="2.4.1.266"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035242.1"
                     /locus_tag="IE198_RS21515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43580"
                     /product="glucosyl-3-phosphoglycerate synthase"
                     /protein_id="WP_189889055.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.2e-10,
                     bitscore: 32.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDEVARWLSRRSWSASDRSLDRLISAKVSQGTTVSVVLPALNEE
                     ATVGDIVTIIRRELMENVPLVDELLVIDSASSDRTSEVAAAAGATVVHRDAILPELPAV
                     AGKGEVLWRSLMVTGGDIVCFCDADLRDFSPDFVAGIVGPLLTEPEVQFVKAMYDRPLG
                     GGAEPGPDGTPAQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAARRSLLERLPFPVG
                     YGVELGLLVDSLNLVGLDALAQVDVGTRKHRHQDGQALGRMAATIYRTAQLRLSRPHLV
                     RPSITQFDRVENGFAPRTYRVDTEERPPMLEIGEYAARRAA"
     misc_feature    18467..18481
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.12"
                     /tool="antismash"
     misc_feature    complement(18468..18481)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.03"
                     /tool="antismash"
     misc_feature    complement(18469..18482)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.2"
                     /tool="antismash"
     gene            18514..18654
                     /locus_tag="IE198_RS21520"
                     /old_locus_tag="GCM10010381_43590"
     CDS             18514..18654
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS21520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_43590"
                     /product="hypothetical protein"
                     /protein_id="WP_189889057.1"
                     /transl_table=11
                     /translation="MSEQQVEMAPTGSTAEQLWLLGGIALSLTAAGLVALAATRGRHRG
                     P"
     gene            19103..20560
                     /locus_tag="IE198_RS21525"
                     /old_locus_tag="GCM10010381_43600"
     CDS             19103..20560
                     /EC_number="2.4.1.15"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005315721.1"
                     /locus_tag="IE198_RS21525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43600"
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_189889059.1"
                     /transl_table=11
                     /translation="MVSDAAQILVASNRGPVSYALNEDGELEARRGGGGLVSGLSAIGS
                     NARSLWVCAALDDGDREALRRGVGEPGVRMLDIGAAVHADAYNGIANSVLWFVHHMLYQ
                     TPLEPVFGQEFRRQWGAYRLYNRAFAEALADEAADDAAVLVQDYHLALVPGMLRELRPD
                     LRIGHFSHTPWAPPEYFAMLPGDVAEELLLGMLGADRLGFLTKRWLRAFQSCATTVLAP
                     YDGTSLWPKDNEPAFEFRIEGRGRHRTRLGVHGLGADADFLRERAARPDVEERMATLRA
                     QAGEGRRTIVRVDRTELSKNIVRGLLAYRELLEERPEWRERVVHIALAYPSRQDLAVYR
                     DYTAEVHRLSDEINAQYGTDTWSPVVVHVKDDFARSLAAYRMADVALVNPIRDGMNLVA
                     KEVPVVTDLGCALVLSREAGAHEELGEDAVTVNPFDVSGTAAALHEALTMSADERAERS
                     KRLAAAATALPPRQWFLDQLDALRDGA"
     gene            complement(20557..21411)
                     /gene="otsB"
                     /locus_tag="IE198_RS21530"
                     /old_locus_tag="GCM10010381_43610"
     CDS             complement(20557..21411)
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006348519.1"
                     /locus_tag="IE198_RS21530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43610"
                     /product="trehalose-phosphatase"
                     /protein_id="WP_189889061.1"
                     /transl_table=11
                     /translation="MGSSPYADAADSMPTPSTPAGRDGLAALLERPGRAVIALDFDGTL
                     AEIVPDPEQARAHERAVPALAALAPKVASVAVITGRPAGVAVRYGGFAGVAGLDHLVVL
                     GHYGAERWDAVTGSVRAPAPDPGVAAARAELPGFLDGIGAWHGTWIEEKGRAVAVHTRR
                     AEDPQAAFDALREPLAALASRHGLILEPGRMVLELRPPGMDKGVALSEYVREVGAEAVL
                     YAGDDLGDLAAYAAVDKLRSDGVPGLLLCSGSEVTELAERADLLLPGPAQVADFLAALA
                     RRL"
     gene            complement(21421..21732)
                     /locus_tag="IE198_RS21535"
                     /old_locus_tag="GCM10010381_43620"
     CDS             complement(21421..21732)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018889530.1"
                     /locus_tag="IE198_RS21535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_43620"
                     /product="DUF3263 domain-containing protein"
                     /protein_id="WP_189889063.1"
                     /transl_table=11
                     /translation="MTDDQGPDDQGPDDQGPDDQGPDDRGSDRQELSGRERAVLAMERR
                     SWRGPGAKERAIREQLDISPVRYYQLLNALLDDPRALAHDPVTVNRLRRVRDARRSRR"
     misc_feature    22502..22519
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.81"
                     /tool="antismash"
ORIGIN
        1 cagcacgaca ccgcctccgg gcgagaagtc ggcgaagtgg ttcaaggtca cggtcacctc
       61 gggcgaccat gcgggcaagg agggctgggt gtggtccgat ctggtccgca accagacgcc
      121 ggacaccccg cggtgcgcct ccgtcggaca cgagaacgac ccaccggcgc ccccgcccga
      181 gcccctgcgg ttcgaggtga cgggcacatg cacctcggac ggcggcgaac tgtccaaccg
      241 ttcctccggt ttcacccccg gcgaggagta ctcggtgtcg gcggcccgcc ccgacggctc
      301 cttctaccgt ctgggcaagg acaccggcac ggtcggggcg gacggttcgg tgacatggaa
      361 gtggccgtgc aagggcgacg cacccggcac gtacagcacc gaactcgtcg acctcggcac
      421 cggccgcgcg gtggaggcgt tcttcaccat cggggcgccg cccaaaggcc ccgcggaagg
      481 ctcggcgaac acaggcggca cgggaggcac gggaggctcg gaacgcgggg cgaacgcagg
      541 cggcgcgggg ggcggaggca acacaggcgg cacggccgct gccggcggct ccggcacgtc
      601 cggcggatct ccggccaccc cgccccagca gccccgagcg gaacggctca cggtcttcaa
      661 caaggtcacg gacggccgca ccaggatgcg ggaagacacc ccggcctatc tgtccaccgt
      721 gacggagaac ttctgcgcgt cccgtggctg cgccctgtcc ggcaccgagg tggtcaccgg
      781 tgaccacctg accgccatct gccgcaccca gggcgcccgt accaccaacg gcaacgacaa
      841 tgactcggcg gacgacacca acgagcagct ggccgagagc cgcctctggt acggagtccg
      901 ctggagcgac ggccgcttcg gctacctctc cgctgtctgg atcgacccgg gtcagcgcgg
      961 cggcctcggc ctcccgtcct gctgagtggc ggggcaggga ccaaagatga tgccgggtcc
     1021 ctgccccggt cttcaggtgc ccgctcagag ccgggtctgc tgcttcaccg tcacgcgccc
     1081 cttgcggatg gtcgccaccc tctccgcccg ccgtgccggc gccgagtcgt gcgtcaccat
     1141 gaccgttcgc cgaccttgtc cacggtggag gcggcgagcg tctcgaagcc ctggaccatc
     1201 acgaccgtcg ttgctctgct cggtgtcgtc gccttcttcc tgggcgtcga tccgactcta
     1261 ccgaatattt tttgcaaaat cttcttggca aagtatgtgg gtcaccctac gctcaccgca
     1321 tgaccgacca ggaccttccc cacgagcatc gcgcccgcgt gctcgacccc cgcgaggacg
     1381 ccgccgcgct caaggcgctg acgcaccccc tgcgcatccg catgctgggc atgctccgca
     1441 tggacggccc ggcgaccgcg agtgaactgg cggtcaggac gggcgagtcg tccgcgtcga
     1501 ccagctacca ccttcgggtg ctggccaagt acgcgttcat cgaggaggcc gagcaccgcg
     1561 acggccggga gcggcggtgg aaggcggtgc acgaggtcac cagctggagc aacgccgcga
     1621 tggccggctc cgtggaggca cgggcgttcg tcgacgtctc acgccgcgcc cagctcgacc
     1681 atctggagcg ttccctcgcc aggcaccagg aggacctggc cgccggacgg ctcggcggcg
     1741 agtggctgga gccgtccggg ttcaccgacc tggtggtgcg gctgaccccc gaggcgctca
     1801 cggagctgcg ggagaccttc aaccgaaccg tcaccgagct ggcagcccgc gacaaggacg
     1861 atccgcgcgc cgagcaggtc gtcctcttcg ccgcaggcct cgccgtccat gccgaggacc
     1921 gttcgtgaaa cggcagttgg acccgcgcgc cgcacgccac cgcttcgtcg ccgtcacctt
     1981 cctgttctgg ctgccggtcg gcctctacat accgtcccag gtactgctcc tgaccgagcg
     2041 cggcatgagc ctcgccgtgg tcgccgggct gttcgcggtc cattcggtca ccgtgtccct
     2101 gatggagctg ccgaccggcg gactgtccga cgtcgtcggc cgccggtcgg tcctggccgc
     2161 cgcgggcctg ctcaacctgt ccgcgctgac catgatggcg ctcggcacca cggtctgggc
     2221 acttgccgtc gcgatgttcc tgatgggctc gggccgcgcc ctgtccagcg gccccgcgga
     2281 ggcctggtac gtggacaccg tgcaggccca ctccggactc gccgccgaac tgcgcaccgg
     2341 tctcgcccgc ggtggcacgg ccgccgccgc cgcgctcgcc ctcggcaccc tcgtcggcgg
     2401 cgccctgccg ctcctgctga gcctcggcgc ggaccccgtc gcctggccgg ccgacgtgac
     2461 cggcgggctc gtgctgccgc tctcggtccc cggcctgctg ggcgcggccg tcggcgtcgg
     2521 gtacgtcgcg tatgtgctga ccgccctgcc ggagccgccc cgagcgcccg ccacgctgcg
     2581 cggggtgctg cgcggcgtcc cggcgacgat gctggacggg ctgcggctcg gtgtcacgga
     2641 gtcgctggtc cgccgggttc tgctgacgtc ggccgccgcc ggcgcggcgc tcgcggccat
     2701 cgagctcctc accccggggc gggcggcccg gctcaccggg gcgcccgagt ccggtgccgt
     2761 gctgtacgca tcgctcgcct gcgccggctt cctgtgcacc gccgtcggca gccactgcgc
     2821 gccactggcg gcccggctga cgggcagcgg cgagcacgcg gtcctggccg ctctcggggt
     2881 gggctcgacc gggctggtgc tgctcggcgt gacggccgcc tgggacggcg gcccggcccc
     2941 gtcggcagtc gccgccgtcg gctacggcct tgtctacctc ggcctcggcg cggcgggccc
     3001 gaacgagaac gacctgctgc accaccgcgt cgacagcacg gtccgcgcga ccgccctgtc
     3061 ggtgaagtcg ctcgcgctcc agtcggtcgc cgcgctgacc ggcctggtcg ccggcttcct
     3121 gccggtcggc ccgctgccgt ggctggtggg cgccgcggcg ctgctggtgg gcgcactgct
     3181 gtggacgcgc cggacccggc cgacggccgt cccggtcgcc ggtgggccgc tccccgcgac
     3241 agagtcgctt cccgggcgtt gaatgagaag catggttctc cagcgacgtg tgggccaccg
     3301 ccgacgcagg gctcccgcag tgacgctcct ggcctccgtc ctcgtggcga ccggcgccac
     3361 agccgccggc gccgcagagc ccccaccacc gccaccgccc cagctcaccg acaagcaggt
     3421 gaacgacgcc gtcgccaagc tcgacggcat cgtccgcgac ggcatggaga agaccggcgt
     3481 cccgggcgtc gccgtcgccg tcgtccacaa ggaccgggtc gtgcacacca agggcttcgg
     3541 ggaacgggag accggcaagc cgggtcccgt gtcacctgac acggtgttcc aactcgcctc
     3601 tctgtccaag ccgctggcgt cgaccgtggt cgcaggcgcc gtcggcgaca aggcgatcgg
     3661 ctgggacgat ccggtggcga agcatgtccc gggcttcgcg ctgaaggacc cgtgggtgac
     3721 cgagcacgtc accgtggccg acctgttctc gcaccgcagc ggcctgcccg accacggcgg
     3781 cgacctgctg gaggacctcg gctacgaccg cgactacatc ctctcccacc tgcgccacct
     3841 gcccttggcg ccgttccgtg cctcgtacgc gtacaccaac ttcggtctca ccgcggccgc
     3901 catggccgtg gccgaggcca agaacaccag ttgggagaag ctggccgaag acaccttgta
     3961 cgcaccggcg ggcatgaact ccaccagttc tcgcttcgac gactacgaga aggcgggcaa
     4021 caaggcggtc acccacgtca aggagggcga cgcctggcag gccaagtacg tacgggacgc
     4081 cgacgcccag tcccccgcgg gcggcgtcag ctccacggcc gaggacatgg ccacctggat
     4141 gcgcctgcaa ctggcgaacg gcaggctcgg cgacgagcgg atcgtccccg ccggcccgct
     4201 cacccgcacc cactggcccg agtccgtcgc ccagcccccg gccggcccgg cggaccgcac
     4261 cggcttctac ggcctcggct ggaacgtcgg ctacgacgac cagggccggc tccgtctcag
     4321 ccactccggc gcgttcggcc tcggcgccaa caccaatgtc accatgctgc ccgcggaaca
     4381 gctgggcatc gtcgtcctca ccaacgggga gccggtgggc ctcgcggact ccatcgcgtt
     4441 caatttctac gacacggccc agtacgggaa gccgaccggc gactggctca ccaggatcgg
     4501 ccaggtctac gagcaggagg agcaggaggc ccgctccccc accgactacg ccaggcagcc
     4561 gtccggcgcc gccgacgcac agcccgtcga cacctacacg ggcacctacc gcaacgacta
     4621 ctacggcgcg ctcagggtca ccgccacgaa cggcgggctg accatggaac tcggcccgaa
     4681 gccgctgcgt ttccccctga cccactacga cgggaacacg ttcagcttcg tcaccgtggg
     4741 cgagaacgcg gtcggccgct ccggcgtcat gttcaccgtc gactcgggcg gcaaggcgtc
     4801 gaaggtccgc gtcgagagcc tcgacgagac gggactcggc accttcaccc gggagtaggt
     4861 gggcccaagt tgacggaagt tgcccggagt tgatcgaagc ctactgaagc cgtaccgtct
     4921 ccgctaacct gcggatgtga gcagggaatt agaagaaaac tccagtttga gcggcagcgg
     4981 ggccacgccc cgtgagccgg gcgacccgcg acggatcggc gccttcactc tgctcggggt
     5041 actcggagcc ggcgggatgg gccgcgtcta cctcgggacg gcctcgggac gctacgccgc
     5101 ggtcaagcag gtgctgccca tcctcgcaga ggacagggac ttcctgcgcc acttcgggca
     5161 cgagctcgac aacctggcca gactccccgc cggtgccagc gcagcgctgc tggccggcga
     5221 ccgcaccgcc caaccgccgt ggttcgccac cgagtacatc cccggcatca ccctgaacga
     5281 cgccgtgcgc gtgaacggcg gaccgctgac cggcaacgcg ctctggctgc tgctgcgcga
     5341 agcggcatcc gggctgcggc gtgtccacgc gaccggcatg gtgcaccggg atctcaagcc
     5401 gtcgaacgtc atgctgacca ccgacagcct caccctgatc gacttcggcg tcgcccgggc
     5461 ggcggaccag tccaggctga cgaggaccgg catggtcatc ggcacccccg cgtacatggc
     5521 cccggaacag gccgtggccg aacgccggct cacgggagcg gccgacgtct tcgcgctcgg
     5581 cagtctgatg ctgtacgcgg cgaacggccg tcctccgttc ggcgacggct ccgggccggg
     5641 cctgctctac cgcatcgtcc acaccgaacc cgacgtcggg accctgccgg acacggaccc
     5701 ggaactgttc gacgtcgtca agtcctgtct ggccaaaagc ccggcggacc ggccgacggc
     5761 cggggaactg ctcgacctcg ccgacgaacg gacgacggcc gaggcagaag cgacatggga
     5821 gtggccctca cccgtcgccg aacggatcgc cgagcgggtg gcgttcgccg cgaccccgcc
     5881 gacggtcgcg gcagagccgg aagaaccgga ggagccggag gaggagcccc gtaaggcgga
     5941 gcccgagtcg cctcccgcca ccacaggggc gaagaagaaa cgccgcatcc gcgtccccct
     6001 ggtcatcgtc atcccgatcg tggtgggcgt cggcacgacg ctgaccctgg ccctcgcccc
     6061 gttcgagtcg acccccgagg ccaagggccc cggtgcgaac tcggccccac cgacgcccac
     6121 cggctcaccg ccggcctccc cctcgaacac cccgtccccg aacgcctccc tctccccctc
     6181 gggctccccg agccccggca cgaccacggc cggcccggct ccgggcgtcc cggcccccgg
     6241 ccctgcccaa ggcggcggcg gaggttcgga cgcaaccggc ggcacggacc ccggcggcga
     6301 ctccggcggc tcggggggcg gcaccaacac cccgggtggc ggccaggccc cgaagccccc
     6361 ggaaccggac accccgcagg gcaaccagcg cctcacgaac tccgccaacg gcaagtgcct
     6421 ggcagagcac atcaacggcg gcctcgtcca ggccgcaccg tctacttgcg gcgctccgtc
     6481 gtccaacggc gggcagatca actacgactg gaacctctcc ggctccggcg gcaccttccg
     6541 cctcgtcagc ggctcgggca gatgcctggc ggcggacacc aacaacttcg tcatgtccct
     6601 cgattcctgc agcggttcct cggaccagct ctggcgcatc ggctccacga catccgccgg
     6661 cagcaccctc aagaacgcct ccaccgaccg gtgcctggcc atgtccgaca cgaacgtgat
     6721 cacgagcggc tgcaacacgt ccgacgcctc ccagctctgg cgcggcctct gactcagccg
     6781 cgcagggtca ccccgtaccg cgtgcgcagc cgggtgagct cccaccacgc gatggcggtg
     6841 accgacgccg ggccgccgac gaccgcacac acctggacga tcggcggacc cggcggcatc
     6901 ccggccgtgg ccagattgat ggccgcgagc tcccacacca ggacgccggt gagcagggcc
     6961 gggagcgccg cgtgcacgtc ggccgtgctg aacgcggtgc ggacgacggt ggtggaggcg
     7021 aacaccacga agaacagcac ccacagcgcc ggaagcagca acgcgagcgt gatcaggggg
     7081 ctgaggcggc tgttcgcata gctctcgctg aggagcatca cacccgtgta cagcaccggc
     7141 accgacgtga acgccccgaa gtaccagagc accgagcgga ccgcgggccg cagccgggcc
     7201 cgcatccccg gccgcgccga cggcggcgcg agccggaaca ggaccagcag cacaagaggc
     7261 acggtgagca tcagcagcca cggggtgatc accagccgga tgaagtactg ctcctgcacc
     7321 tcgttccagt ccgcctccgt gccgtaggcg gccaggatca ggaaggacgc gcccagcgcg
     7381 acccaggccc gtgtcttctg cgcacgccac acctcggggt cgtggtactg gcggatgctg
     7441 ttcacgggga accgccgacg cgcctgccga cgagccgacc ttgccagcgg ataccccacc
     7501 aggacggcca gcgcgggcca cacacagcac ataccgagcg ccaagaggca gccgggcacc
     7561 cttcgcacct cggcgagcaa ctcccgcaat ggcggccatt cgtcgtcccg gaaccgctgc
     7621 cacagcgacg gaggcggacc gtacggacgg tacggcggcg ggcccggatg cgggcccggg
     7681 cccggctgcg gctgcccgtt ccgccggtac ggattctgtc ccccgaatgt cacgcctgcg
     7741 tccttcctgg agtggtacga cgatcattcc aggaatgcga accgccgggc gtcgcagccc
     7801 atatggcgcc cggtcggcct tcgtcgccgg tctcgagcgc ggccgggacg acgtcgccgt
     7861 atttccctca gctcgagttc cgggattcga gctctcttca cagcgatgtt ggggggcgtc
     7921 ccgtttcaac ccacccgagc cccaccgggt tgacaccacg cgatcgggtt gccacgcagc
     7981 gtcatcctgc tctggcgttc cgatgaacga acaacccgcc atgtgctacc cacacctgcg
     8041 ggcccgacca acgagatcga tccagaggcg atcccatggc cgactgccac gccctacggc
     8101 cagtacgcca ccggacatcg ccctcgaaac ggagaagctc aaggactgct cccaggcgta
     8161 gactcggccg catgagccga cgacgacatt gatccaccgc ctcaggtccg ggaacgggct
     8221 gtcgagggcc gccgcgcggg tgagcacccg gcgtcccccg tccgttccgc agaaggacca
     8281 cacgcatgct caccgtttcg tcgtgcccgc tcggcccccg cacttccggc gtccgcagtc
     8341 ttgagcgaaa gctctacgcc tacgcgggac ttgaggactt cgtcctcctc tatcccctct
     8401 acgccctgct cttcgccgag cacggcctga ccaccgccga gatctcgtcc ctgttcgcca
     8461 tttggtgcgt cgtcggcctg ctggtcgagg tgccgtccgg tgtgtgggcg gacgtcgtgt
     8521 cgcgcaaggc gctgatggtg atcggaccgg tgctgaccgc cggcggattc gccctctggg
     8581 ccctcactcc ctcgtacgcg gcctatgccg ggggcttcac gctctgggcg atcggcggat
     8641 cgctgcgctc cggttccatg gaggccctcg tgcacgacga gctcgaacgg ctcggcgcgg
     8701 ccgaccggta cgggcgggtc atgggccggg cggcggccgt cagcatggcc gcgaccgcca
     8761 cggcgaccgc cgccgccgcg cccgcgctcg ccttcggcgg cgagacgctg gtctggggcg
     8821 gaagcatcgc cgcgtgcctg ctctgcgcgg cggtcggcgc gacgctcccc gagcaccgcg
     8881 ccaccggcca ccacgggaag gcccgacgac ccggctgcat cgcgacgttg cgggacggcc
     8941 ttgacgaggt acgcggcagc aggcccgtcc gccgcgccat ggtcctcgcc gtcgtgatca
     9001 cgtctgtgtg gggcgtcctg gacgagtacg taccgctgct ggccgcgtcc acgggcgtcg
     9061 cgacgcagac cgtaccgctg ctggtgctgg tggtgtgggt gggcgtgaca ctcggctcgc
     9121 tgctggtggg gccgggcgaa cggctcaccg accgtacggc ggccacgctg gtcgcggtgg
     9181 ccgccgtcgc tctcgccgcg ggcgcgctgt ccggcacgct cgccggattc gtgctgctcg
     9241 gcgccgcgtt cggggtgttc cagctcgcgg acgtgttggc cgacgtacgc ctccaggcgg
     9301 cgatcaacgg cccgagccgc gcgacgatca cctcactgac cggcctgggc accaacatcg
     9361 cctccctgct ggcgtacggc gcctacgcgg cgctgtcccc gcacgcgtcg cacggcgctg
     9421 tcttcgcgtt gctgggcctg ccctacctgc tggtggccgg cgccctgggc cgaccgcggc
     9481 cggcccccgc accggcgggt caggaggcgc agtagcggtc cttctcgggg gtctcccgtg
     9541 agcaggaatc gggtcacggt cgcgtcgccg taccccgtgc gcccggtagg cgccgtggcc
     9601 caccccgtcg acggtcacca tccgggcgcg gtcgccgacg cacgcatcct gagcgccccc
     9661 agggcgggca tggtccaacg ggaccgggac agtgccgcat tcctgccgcg gatcgagccc
     9721 gctgccgggg cacggccccc gacggacggc ggaatgcggg cgcggggtcg ccgcctctgc
     9781 ggccggtgcc gcggggacga ggaggggtgg tcgcgaaaag gggcagggtg agggccgcgg
     9841 cgcctgagat ggggtggcga ccgccgggcc tgcgaggaat cgtcatgtca cgaccctcgc
     9901 ggaacgggcg ctcgcccccc atggggcagg gcaggtctct tcagggtggg ggcccgcccc
     9961 cctcggccct tcgggccggc gccccattgc cgagttcccg tcaactcctg cccggtgtac
    10021 gtcccttcgc cggcgccacg gtgatcaggc gggcgaggct gtcggagcgg ccccgttccc
    10081 cgatcagttc accgtccacc tccacccatg cgtgcgcggc gaacggcggt gccgcccgca
    10141 cgccgacgca ccaggtgggc cacacaccct ggaggcggca gagcagggcg atggataccg
    10201 agcgcggcag gcaggagcgc aggccgttga ggctgaggcc ggcggccagg accgagtccc
    10261 gggcggcgtt cgcctgtgcg ctgtccgcgg cggcggcgtt ccggctgagc cgggtcagca
    10321 cccgtgtcag caggtggggt ttgaggagga ccagcaaccg ggcggcacag atcgccagcc
    10381 gggtgagaag ccgtagcttc agcggccttc tggcccggtc tctgtccagg gcgacggtga
    10441 tgctcactcc tgcaccaccc cggccgacca catggcctcg atcagggccc gcacgtcgtt
    10501 cgcggcgcgc tccgtgtcca cctcgaagtg gtcggtgacg cgtcgcacgg cgtcatcggc
    10561 gtcgccgccg tccagcagtg cctgggcggc cgtggcggcg ctggggttca tctgccagta
    10621 ctcaccggtc ttggtgtcca gcagcaccgc accgtattcg gtctccgtga cggtcaggta
    10681 cgggcggttg cgcagcttca tcgcattcct tccttccggc cgggcacgtc aggcgactgc
    10741 gcgcagccat gcttcgcaga tgatggtgga gtcgacggcg ccgttcttga ggtcgggcgt
    10801 gccgggcctc tcggtcagcc gggcgagcgc gccggcgtcg atgagcccgg ccttggccag
    10861 ggcgctgtcc tcccacaggg cgcggatctt gtcgcggtgc cggtagagcc cgccgaccgc
    10921 gtcgacggtg ccttcgaact tggtggtgcg ggcccggcac tgctcgggga ggatgccgcg
    10981 taccgcctcc ttgagcaccg gcttgtactg ccaggggtcg gcccgctcct cggggcgtac
    11041 cgacagcgcg gcgtcgacca ccgcgtcgtc gaagtagggc atggtgacgg gcacccccgc
    11101 acggcgtccg gcttcggcga tcgccgcgca ctcctgtgtc ccggagtaca gggcggacag
    11161 ttcccggtgg cggccgagtg tgggtgcgta gggctcggcg tggcgggcgg cctcccgcag
    11221 cccggcggcc accagttcgc ggcactcggg ggtgagccag gactggacca ccggcggggc
    11281 gacgtaggcc agttgggggg tgctgaagcc gaggtcgccg ggagcggtca gatcggtggc
    11341 ggccaccgcc cggcggtagg agcgccggtc ggcgagttgg cgcagcacgg ggcgccagcg
    11401 ccatccgtag agcgtgcggt agccgcggat ccgctggaat gccagcaggg ggcggcgggc
    11461 gatcaggtcg tggcagtagg cgccggactg gaagaagagg tggtcgccgc cgtgcccggt
    11521 catgtgcagc cgggagccgc gccgcgccat cacggagatc accgcggtgg cacggtcgcg
    11581 gctcatggcg acgcccgcgg ggatgtcggt gcggcagccg tcgtcgagga tgccctggta
    11641 gaacagcggt gtctgttccg gtgtcagttc catgtgttcg acgtgcggcc aggacgcgga
    11701 ggcgagacgg gcgtagtgcg cgtcgtcgtt gaccgactcg tcgccgggaa tgccgccgac
    11761 gatcagttca cccgggccga gctgtccggc cgcgatggcg cacagcgagg tggagtccag
    11821 tccgccggac aggtccgcgc tcagcaggcc gtcccgtgcc gtccgtacgg cgacggctgc
    11881 ggccagcgcc tcgcgtacgt ccgcggcgcc ctgtgccttc gtacgctcgg ggacgggcgg
    11941 gctgtgccag aggacgtgcc ggggcggggc gccgtcggcg ggggcgagca gatacgcacc
    12001 gggcgccacg tccgtcacgc cgcgccacat ggggcgcggg ggcagctgga cggccagcgg
    12061 ttcgggcagc cgcagcgcca cggaagtgag gtcgacctcg gcaccggcca cgtctgccaa
    12121 cgccacggca cggtcaccgg ccacggggca gccgtccacg acggcgtggt gcacccgccg
    12181 catgccgtag gcggtgcctt gtacgtacag ggcgccgccg acgctgccca cgacatggaa
    12241 gctgccgggg atcgccgagg acaggccctc gagccgtgcg gccctgccgt gcagccggcc
    12301 ggcccgacgg gacagctcgc ccgtccgctt cggcagcatg ccgatcagcg cgacggcgtc
    12361 cgtaccggcc ctggcgacgg cgatgtcctc gtcggcccat tcaccgatga tccaggggcg
    12421 gccggaggga tggtggagca cccgcagacc gggtgccgcg ccatggaggc gacgggccac
    12481 ggcgcccgct tcctcgcggt cgggaagcgc aaagaaatgc ggtgcgccgt ggctggtcat
    12541 cgcggattcc tccgggtgcc gtcagagcca gccgcggccg gtaccgtcgt tgccgaagaa
    12601 caccaggaag ccggtggcac cgcggaagga gccggcggaa acgaactccg gagtctcgta
    12661 gaacgccttc ttcgtcatgg ttcacgtcct ttctctctga atggagtggt caaacgatcg
    12721 gcagaatcct cgctgccgcg acgtgaaccg ggccagggcg ctggcagctt ggtgccgggc
    12781 agaggacggg cttggcaggc agggtcggac ttcgcatgac cgggccgggt gacccgcgtc
    12841 acagccaccg gtccgaggag gcagggccgt gcccgaacgc gcccgagggc ggcacccctg
    12901 ggagtggggt gccgccctcg gtcaggacgg ttgatcgacc gggtcgatca gaagtccatg
    12961 tcaccgcccg gcatgccgcc gccggccggc gcggacgcct tctccggctt gtcggcgatg
    13021 acggcctcgg tggtgaggaa cagcgccgcg atggaggccg cgttctgcag ggcagagcgg
    13081 gtcaccttgg cggggtcgat gatgccctcg gcgatcatgt cgacgtactc accggtcgcg
    13141 gcgttcaggc cgtggccgac gggcaggttg cgcaccttct cgacgatgac gccaccctcg
    13201 agaccaccgt tgacggcgat ctgcttgagc ggggcctcga gcgcgagctt cacggcgttg
    13261 gcgccggtcg cctcgtcgcc ctggagctcg agcttctcga agacagagga ggcctggagc
    13321 agggccacgc caccaccggc gacgatgccc tcctcgacgg ccgccttcgc gttgcggacg
    13381 gcgtcctcga tgcggtgctt gcgctccttg agctcgacct cggtcgcggc accggccttg
    13441 atgacggcca cgccgccggc cagcttcgcg aggcgctcct ggagcttctc gcggtcgtag
    13501 tccgagtcgc tgttctcgat ctcggcacgg atctggttga cgcgaccggc aacctggtcg
    13561 ctttcaccgg caccgtcgac gatcgtggtc tcgtccttgg tgatgacgac cttgcgggcg
    13621 cggcccagca ggtccaggcc ggcgttctcg agcttgaggc cgacctcctc ggagatgacc
    13681 gtgccgcccg tgaggatggc gatgtcgttc agcatggcct tgcggcggtc gccgaagccc
    13741 ggggccttga cggcaacgga cttgaaggtg ccgcggatct tgttgacgac gagcgtggac
    13801 agggcctcgc cctcgacgtc ctcggcgatg atcagcagcg gcttgcccga ctgcatgacc
    13861 ttctccagca gcggaaggag gtccttcacg ttgccgacct tggagttgac gatcaggatg
    13921 tacgggtcgt ccagggacgc ctccatacgc tccatgtcgg tggcgaagta cgccgagatg
    13981 tagcccttgt cgaagcgcat accctcggtg agctccagct ccagaccgaa ggtctgggac
    14041 tcctcgacgg tgatgacgcc ttccttaccg accttgtcca tggcctcggc gatgagctcg
    14101 ccgatctggg tgtcggcggc ggagatggag gcggtggagg cgatctgctc cttggtctcc
    14161 acatccttgg cctgctcgag cagggcgccg gagacggcct cgacggcacg ctcgatgccg
    14221 cgcttcaggg ccatcgggtt ggcgccggcc gccacgttgc gcaggccctc gcggacgagc
    14281 gcctgggcga gaacggtcgc ggtggtcgta ccgtcaccgg cgacgtcgtc cgtcttcttg
    14341 gcgacttcct tgaccagctc ggcgccgatc ttctcgtacg ggtcctcgag ctcgatctcc
    14401 ttggcgatgg aaacaccatc gttggtgatc gtgggggcgc cccacttctt ctcgaggacg
    14461 acgttgcgac ccttggggcc aagggtgacc ttgacggcgt cggcgagctg gttcatcccg
    14521 cgctcgagac cgcgccgtgc ctcctcgtcg aacgcgatga tcttggccat gtgaagtggt
    14581 cctcccggac tggggtggat tgcttcggat cgcatccggc gcccgcgacg gacggcctgc
    14641 gcgccatgtg gttccttgcc ccacccggcc cgcgggcctc accgacccga tccaagttct
    14701 gtcactctca ctgggagagt gctaacgcca atgattagca ctcgacccct gagagtgcaa
    14761 gcggcttcga ggaagcgtcc tcgaggggct ggggtcggac gacaggaggg cgggggcacc
    14821 tcaggcgggt ccccgtgccg cccggacacg cgcgaggggc ccgcgtcccg gtgaacggga
    14881 tgcgagcccc tcgtgtgtga gtgcgtcggt ggccgatcgc gcctggatca gttggatcag
    14941 acggcgagct tgaccatgtc cgcctgcgga cccttctggc cctgcgagat ctcgaattcg
    15001 acccgctgac cctcttcaag ggtgcggtat ccgtccatct ggatggcgct gtagtggacg
    15061 aaaacatccg caccaccgtc gaccgcgatg aagccgtacc ccttctccgc gttgaaccac
    15121 ttgacggtgc cctgagccat gcctaactcc cctattactg gcccttgcac aggaccgcac
    15181 ttcgcggacc cgggtcagac ctcaccccga caggaggggt gtgcgccgga acgcgtcgac
    15241 cgcggctgaa tgtatctgcc caactgccct ctgcaacagg tcaatcggac gagaaatctg
    15301 ggcaggaccg aacgaccgat ccatacgatt ccacggaatt ccggggcaat tcgggcccgg
    15361 caaatggcgc ctaagtggca attcgatcac gcagtttggc cgcattctta cggaactcga
    15421 aggcattcca gagcggccgg cggagggggc ttcccagact ctaccgcgct caaccatgca
    15481 gaattgcccc ctccgcttct cttgcggagg gggcaattcg agtaactgtg ggtaagtcct
    15541 tgggggtggg atcagccgcc ggcgaccgcg gggatgatcg acacgcccgc accctccggc
    15601 gtggccgtct ccaggccctg ctcgaaccgg acgtcgtcgt cgttcacgta cacgttgacg
    15661 aaccggcgca gcttgccctg gtcgtccagg acacgggccg cgatgccggt gtggttcttc
    15721 tccaggtccg cgatgacctc ggcgagggtc gcaccctccg ccgtcacctc ggcccgaccg
    15781 cccgtgtacg tacggaggat ggtggggatg cggacgttga cgctcatggt gcagccttcc
    15841 ttgtcttgag gtctcagcgg tctcagccgg ccaggccggc ggcgcggaac gcatccaggc
    15901 tcgggcggat gacggcggtc gcctgagagg tatccgcgac cgcgtcgagg gtcttgagac
    15961 cgtcgccggt gttgaggacg acggtggtga gcgccgggtc gagcacaccc gcctcgatca
    16021 gcttcttcgt cacacccacc gtcacgccac ccgccgtctc ggcgaagatg ccctcggtgc
    16081 gggccagcag cttgatcgcg tcgacgacct gctcgtcgtt cacgtcctcc accgcgccgc
    16141 cggtgcggcg tgcgatgtcc agcacgtacg ggccgtcggc cgggttgccg atggccagcg
    16201 acttggcgat ggtgttcggc ttctggggcc gcaccacgtc gtgcccggcc ttgaaggcgg
    16261 tcgacaccgg ggagcagccc tccgcctggg cgccgaagat cttgtacggc ttgtcctcga
    16321 cgagcccgag cttgatcagc tcctgcagac ccttgtcgat cttcgtgagc tgcgagcccg
    16381 aggcgatcgg gacgacgagc tggtcgggca gctgccagcc gagctgctcg cagatctcgt
    16441 acgccagggt cttggagccc tccgcgtagt aggggcggag gttgacgttg acgaagcccc
    16501 agccctcgcc cagcgggtcc ccgatgagct cggagcagaa gcggttcacg tcgtcgtagt
    16561 tgccctcgat gccgacgagc tccccgccgt acaccgcggc catgacgacc ttgccctgct
    16621 ccaggtcgtg cgggatgaac acgcaggagc gcaggccggc ccgcgcggcg gcggcgccga
    16681 ccgcgcccgc gaggttgccg gtggaggagc aggacagcgt ggtgtagccg aaggcgcggg
    16741 cggcctcgag ggcctgggcg acgacacggt ccttgaagga gtgcgtcggg ttgccggagt
    16801 cgtccttgat gaacaggctg ccggtcacac ccagttcacg ggcgaggttg tcggccttga
    16861 cgagcttggt ccagcccggg ttcaggttcg gcttgtcggc cacgtcggcg gggacgggca
    16921 gcagcggggc gtagcgccag atgttggccg gaccggcctc gatccgcttc cgcagctctt
    16981 cggggctgcc gctcggcagg tcgtaggcga cttcgagcgg cccgaaacac tcggcacagg
    17041 cgaagatggg gccgagctcg aaacgctgcc cgcattcgcg gcaggaaaga gcggcggcgg
    17101 gtccgaggtc cacgggggtg gtggtggcgg aggtgctcgt gcttgcgacg gtctgcgcag
    17161 ccatggtggc gaggcccttt ctcctcatct tcctcgtgac gcacttcgcc acgagccgga
    17221 attggcacct tccccaccgt gacctcgcgg tcggcgggag ggttgccggg gcttcaacgg
    17281 gccgttccct ctgcccctct ggatgagcgg tatggctccg gacgtgcggt ccgggcgttt
    17341 gtgtgcttgg accccccgag atgcgagggt cgttcgcgtt gttcaagact gtaaccgaag
    17401 ccccggacgg ttgagatagt cgtccgaacc gcgagatgga tcacacgccc gactgtttgt
    17461 cgactgccta gggagacgcg aagtgctcga tgaggtggcc cgctggctga gccggcgctc
    17521 ctggtccgcg tccgaccgct ccctcgaccg actgatatcc gccaaggtca gccagggtac
    17581 gacggtcagc gtcgtgcttc ccgcgctgaa cgaggaagcc acggtcggcg acatcgtgac
    17641 gatcatccgc cgcgagctga tggagaacgt tccactcgtc gacgaactgc tcgtgatcga
    17701 ctcggcctcg agcgaccgca cgtccgaggt cgccgcggcc gcgggggcga cggtggtgca
    17761 ccgcgacgcg atcctgcccg agctgccggc cgtggccggc aagggcgagg tgctgtggcg
    17821 gtcactgatg gtgacgggcg gcgacatcgt ctgcttctgc gacgcggacc tgcgcgactt
    17881 ctcgcccgac ttcgtcgccg gcatcgtcgg tccactgctg acggagccgg aggtccagtt
    17941 cgtcaaagcg atgtacgacc gccccctcgg aggcggggcc gagcccggcc ccgacgggac
    18001 cccggcccag ggaggccggg tgaccgagct ggtggcacgg ccgctgctga atctgcactg
    18061 gccgcagctc gccggcttcg tccagcccct cggcggcgag tacgcggcgc gccgctcgct
    18121 cctggaacga ctgccgttcc ccgtcggcta cggcgtggag ctgggcctgc tggtcgactc
    18181 gctgaacctg gtgggcctcg acgcgctcgc ccaggtcgac gtcggcaccc gcaagcaccg
    18241 ccaccaggac gggcaggcgc tcggcagaat ggccgcgacg atctatcgca cggctcaact
    18301 gcggctgtcc cggccgcact tggtacgccc gtcgatcacc cagttcgacc gggtcgagaa
    18361 cggattcgcc ccgcggacct accgggtgga cacggaggag cggccgccga tgctcgagat
    18421 cggtgagtat gcggcgcgtc gcgcggcata agccgaatct gtcggtcatt ttgtctaaat
    18481 ttcccactta tgggactcat cagatttctc gtggtgtctg aacagcaggt ggaaatggcc
    18541 cccaccggca gcacggcgga acaactgtgg ctcctgggcg gtatcgctct cagcctgacg
    18601 gcagcgggac tcgtcgccct ggccgccacc cgcggccgcc accgcggccc ctgacgctct
    18661 ccggcctgtt cccctcccgg ccctgcccga accggggctc cgcccgggac ccaccaccac
    18721 cccgctccac tcggtgccct gaacccctac ggcccggcgg ctgcgggacg caccacgcgc
    18781 ccggaccggc cggagccgga ggcgcggggc cggggcgcag gcgccggcca gtcgctccgg
    18841 gccgggcccg ggcgtgcgcc cggtttccgg gtgggggcgg ggggccccgg tttcaggaag
    18901 ggacgaggag gggacggctc ccccgccggc gtcggggcgc aggccccggg gcccgcggcg
    18961 cgaggccgtc accgtgggcc cgggggcaac agccccgaaa ccgggagggg ccgggggcgc
    19021 cccgtttcgg ggagggggcg gcttcccgcc gaggaccgga agcaacgttt gagggcccgc
    19081 ggtacgggct aggtttcggc acatggtctc cgacgcagcc cagatcctcg tcgcgtccaa
    19141 ccgcggccca gtctcgtacg cgctgaacga ggacggagag ctcgaagccc gccgcggtgg
    19201 tgggggactc gtctccggcc tgtcggccat cggctcgaac gcccggtcgc tctgggtgtg
    19261 cgcggcactg gacgacggtg accgtgaggc cctgcggcgc ggcgtcggcg agcccggcgt
    19321 acggatgctc gacatcggcg cggccgtcca cgccgacgcg tacaacggca tcgccaactc
    19381 ggtgctgtgg ttcgtccacc acatgctcta ccagacgccg ctggagcccg tcttcgggca
    19441 ggagttccgc aggcagtggg gcgcgtaccg gctctacaac cgggcgttcg cggaggcgct
    19501 cgccgacgag gccgccgacg acgcggcggt gctggtgcag gactaccacc tggcgctggt
    19561 accggggatg ctccgcgagc tccgcccgga cctgcggatc gggcacttct cgcacacccc
    19621 gtgggcgccc cccgagtact tcgcgatgct gccgggcgac gtcgcggagg agctgctgct
    19681 cggcatgctc ggcgcggacc gcctcggttt tctgaccaag cgctggctgc gggcgttcca
    19741 gagctgcgcc accaccgtgc tggccccgta cgacgggacg tccctgtggc cgaaggacaa
    19801 cgagccggcc ttcgagttcc ggatcgaggg ccggggccgc caccggaccc ggctcggggt
    19861 gcacgggctc ggtgccgacg ccgacttcct gcgcgagcgc gccgctcggc ccgacgtcga
    19921 ggagcgcatg gccaccctgc gcgcccaggc gggcgagggc cggcggacga tcgtccgtgt
    19981 cgaccgcacc gagctgtcca agaacatcgt gcgcggcctg ctggcctacc gggagctgct
    20041 ggaagagcgc cccgagtggc gtgaacgggt cgtgcacatc gcgctcgcct acccctcgcg
    20101 ccaggatctc gcggtctacc gcgactacac ggcggaggtc caccggctct ccgacgagat
    20161 caacgcgcag tacggcacgg acacctggtc gccggtcgtc gtgcacgtca aggacgactt
    20221 cgcccgttcc ctggccgcgt accggatggc cgacgtggct ctggtcaacc cgatccgcga
    20281 cggcatgaac ctggtcgcca aggaggtccc cgtcgtcacc gatctcggct gcgccctggt
    20341 gctgtcgagg gaggcgggcg cccacgagga gctcggcgag gacgccgtca cggtcaaccc
    20401 gttcgacgtc agcggcaccg ccgccgcgct gcacgaggcg ctgacgatgt cggccgacga
    20461 gcgcgccgag cgttccaagc gcctggcggc ggcagcgacc gcgctgccgc cgcggcagtg
    20521 gttcctcgac cagctggacg ctctgcgcga cggtgcctag aggcgccgcg cgagggcggc
    20581 caggaagtcc gccacctgcg cgggcccggg aagcaacagg tcggcgcgct cggcgagttc
    20641 ggtgacctcg ctgccgctgc acagcagcag cccgggcaca ccgtcggagc ggagcttgtc
    20701 gacggcggcg tacgcggcga ggtcgcccag gtcgtccccc gcgtacagca cggcctcggc
    20761 gccgacctcc cgtacgtact cggacagcgc gacacccttg tccatgcccg gcgggcggag
    20821 ctcgaggacc atgcgccccg gctccaggat caggccgtgc cgggaggcga gcgcggcaag
    20881 aggctcgcgc agggcgtcga aggcggcctg agggtcctcg gcgcggcggg tgtgcaccgc
    20941 gacggcacgg cccttctcct cgatccaggt gccgtgccag gcgccgatgc cgtcgaggaa
    21001 tccggggagt tcggcgcgcg cggccgcgac ccccgggtcg ggggccggtg cccgtacgga
    21061 gccggtgacc gcgtcccagc gttccgcgcc gtagtgaccg aggaccacga ggtggtcgag
    21121 gcccgcgaca ccggcgaagc cgccgtagcg gacggcgacg ccggcggggc ggccggtgat
    21181 caccgcgacg gaggcgacct tcggcgcgag ggcggcgagc gcgggcacgg cgcgctcgtg
    21241 ggcacgcgcc tgctcggggt cgggaacgat ctcggcgagt gtgccgtcga agtcgagggc
    21301 gatcacggct ctgccgggcc gttcgaggag tgccgcgagg ccgtcacggc ctgcgggggt
    21361 ggacggcgtc ggcatggagt ctgctgcgtc tgcatacggg gagctgccca tgccccgacc
    21421 ctagcggcga cttctcctcg cgtccctcac acggcgaagc cggttgacgg tgacgggatc
    21481 gtgggcgagg gcgcgcgggt cgtcgaggag ggcgttgagc agctggtagt agcggaccgg
    21541 ggagatgtcg agctgctccc tgatggcccg ctccttggca ccgggcccgc gccaggaacg
    21601 ccgctccatg gccagaacgg cccgttcgcg cccggacagc tcctggcggt cggaaccccg
    21661 gtcgtcaggc ccctggtcgt caggcccctg gtcgtcgggc ccctggtcgt cgggcccctg
    21721 gtcgtcggtc atacgaccaa catatcggcg tgctccgacg tccggaccgc cctgtggaca
    21781 acaccccggc gggcctactc cgcggcttcg gccgccctgg cgtcctggga gatccggctc
    21841 agtgtgcggg cggcgctgcc gcccggtccc acggcctcgc cgatgttctt cttgatgtcc
    21901 tcgctcgccg acgcccacga cgtcttgccc accggcggca gcacggagcc cggcagtacc
    21961 tccaggaagt ccttgaggtc cgcgtgctcc gggtcgttcc gcatcgtctc ctgggcggag
    22021 accgtcaccg gcagcagatc gttctggccg gcgaactcca tgacgttctc gtcggcgaag
    22081 aggaagtcca ggaacgtgcc gatctccttg cgatggccgt tctgcttgaa gcccatgatc
    22141 cagtcggcga cacccatcgc cgcgtcggcc tcgccgtcct tgccgggcat cgccaccgta
    22201 ccgacgtcga tgcccgcctt ctcggcggcc tgcagcagcg acggatggcc gttgagcatg
    22261 ccgacctcac cgcgggtgaa ggcggcgaag gcgtccttgc ggttgagctt gccgggggcg
    22321 accgggccgg tgagctccgc gtcgaccagg ttttccttca gccactcgaa ggtcttgatg
    22381 ttctgcgggg agtcgatcgc gtatctgccg agctcgtcgg tgtaaccgcc gccgccgctg
    22441 agcagccaca tcatcgtctc cgcctgcgcc tcctcggggc cgagcggcag cgcgaagggg
    22501 tatgtgacgt cggtgttcag cttgagccgc tccgcgtcct
//
