LOCUS       NZ_BMWB01000013        23313 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence13, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000013
VERSION     NZ_BMWB01000013.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 199998)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 23313
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23313
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NI-siderophore"
                     /region_number="1"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..23313
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23313
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4626:9313](+)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4627..9313
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     misc_feature    36..55
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.27"
                     /tool="antismash"
     gene            complement(43..1212)
                     /locus_tag="IE198_RS19615"
                     /old_locus_tag="GCM10010381_39670"
     CDS             complement(43..1212)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010063475.1"
                     /locus_tag="IE198_RS19615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39670"
                     /product="serine protease"
                     /protein_id="WP_189888359.1"
                     /transl_table=11
                     /translation="MRSIRPLLAAAGLVTALGLTATACGPSENDAADKPAASSPAADNG
                     GAAVPADLADKLKERGVDLDQWKNGEWKNWDKDKWLREAKDFVNPVIEGLWKPERMTTA
                     KAPAKTMAAGDISGDQGVTDPEPRPVRAEPEKKPYHKNAAPVGKVFFDAPEGSMVCSAT
                     VVKDPKNPGRSNLVWTAGHCVHAGRAGGWYRNIAFVPAYNDQGKSPAALENAQPHEVAP
                     YGVYWADWVATSGEWIDEGGPTGGTGAPYDYAVMHVKPEQGTKSLEETVGVALDIDFDA
                     PEAKDISAMGAWGYPAAPPYDGALMHKCVDRPGRLSIAPGTPTMWRIGCTMTGGSSGGG
                     WFAEQPNGKLALVSNTSIGPVTSGWLAGPRLDQGAQQIYTMMSDKFAGQ"
     gene            complement(1656..2831)
                     /locus_tag="IE198_RS19620"
                     /old_locus_tag="GCM10010381_39680"
     CDS             complement(1656..2831)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311082.1"
                     /locus_tag="IE198_RS19620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39680"
                     /product="serine protease"
                     /protein_id="WP_189888361.1"
                     /transl_table=11
                     /translation="MRPIRPTLAAASIAAVLALAATACGPSEDSAGDKPSAPASQSADG
                     KITIPDDLKDRLKEHGIDLDKWKNGEWKNWDKDKWLREAQDFVNPIIEDLWDPDRMRDA
                     DKPPEKPVDNDISGDEGVTDPAPAPVDAQAVKAPYHANAAEAGKVFFDGPQGSMVCSAT
                     VVKDPANPGKSNMVWTAGHCVHAGKSGGWYRNIAFVPSYNDGAKETAELEKAPKEEIAP
                     YGVWWGDWAQTSDQWISQGAATGGQGAAYDFAVIHVTPEKGGNGKSLEETVGSALPVDF
                     NAPAVPKIANMTATGYPAAPPYDGQKLFQCADKPGRLSLNADEPTMYRIGCTMTGGSSG
                     GGWVAQGQDGKPALVSNTSIGPVTAGWLAGPRLGKDAEGVYNAVSKKFAGQ"
     gene            3206..4597
                     /locus_tag="IE198_RS19625"
                     /old_locus_tag="GCM10010381_39690"
     CDS             3206..4597
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (40-375). E-value: 1e-88.
                     Score: 289.5. Matches aSDomain:
                     nrpspksdomains_IE198_RS19625_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889955.1"
                     /locus_tag="IE198_RS19625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39690"
                     /product="diaminobutyrate--2-oxoglutarate transaminase
                     family protein"
                     /protein_id="WP_189888363.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.6e-88, bitscore:
                     290.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVTEPAPVAPTAAHEGILRRQSLRESAARTYARSLPIVPVRARG
                     LTIEGADGRRYLDCLSGAGTLALGHNHPVVLEAIKKVIDSGAPLHVLDLATPVKDAFIT
                     ELFATLPRPLAEDARIQFCGPAGTDAVEAALKLVRTATGRSGLLAFTGAYHGMTAGALE
                     ASGGATDVRVTRLPFPHNYRCPFGIGGERGAELAARWTESLLDDSKSGVPTPAAMILEP
                     VQGEGGVIPAPDEWLRRMRVLTAARSIPLIADEVQTGVGRTGTFWGVEHSGVVPDVMVL
                     SKAIGGSLPLAVVVYRSELDAWPPGAHAGTFRGNQLAMAAGAATLAHVRENALAERAGT
                     LGARMLASLQGLAAAHPCIGDVRGRGLMIGVELVEPDSMAPDAVVPPPAPQLAAAVQQE
                     CLHRGLIVELGGRRAGVVRLLPPLTLTDEQAVAVLDRFADALAAAERSTQRRTDNRQSH
                     NRQSN"
     aSDomain        3326..4330
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS19625_Aminotran_3.1"
                     /evalue="1.00E-88"
                     /label="IE198_RS19625_Aminotran_3.1"
                     /locus_tag="IE198_RS19625"
                     /protein_end="375"
                     /protein_start="40"
                     /score="289.5"
                     /tool="antismash"
                     /translation="VRARGLTIEGADGRRYLDCLSGAGTLALGHNHPVVLEAIKKVIDS
                     GAPLHVLDLATPVKDAFITELFATLPRPLAEDARIQFCGPAGTDAVEAALKLVRTATGR
                     SGLLAFTGAYHGMTAGALEASGGATDVRVTRLPFPHNYRCPFGIGGERGAELAARWTES
                     LLDDSKSGVPTPAAMILEPVQGEGGVIPAPDEWLRRMRVLTAARSIPLIADEVQTGVGR
                     TGTFWGVEHSGVVPDVMVLSKAIGGSLPLAVVVYRSELDAWPPGAHAGTFRGNQLAMAA
                     GAATLAHVRENALAERAGTLGARMLASLQGLAAAHPCIGDVRGRGLMIGVELVE"
     gene            4627..6591
                     /locus_tag="IE198_RS19630"
                     /old_locus_tag="GCM10010381_39700"
     CDS             4627..6591
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311076.1"
                     /locus_tag="IE198_RS19630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39700"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_373299900.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.2e-74, bitscore:
                     244.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPIPVPDAPESHDGPAGHHRDTCGASGPLTMEPVTVPRQPGRLD
                     EQRGGRAGTLAQADGPGRPGAETDRLDHRAHHGPVDHRDPLDDLDERRAADTATVENLL
                     RCWVRENDLTRPEGHTLRIPLDASGTALLVPVHYWSATGWHRFGAPALEGSSREATRAD
                     AVTVAALLGREAGHAEGTDLVARVADSVRRTAGFIADRRERPAAPPEADLFLTAEQSLL
                     LGHPLHPTPKSREGLSDAEARSYSPELYGSFRLHWMAVDKSVLAAESAWTEQGRAVTAE
                     QLTSRLAGDLPLPDNTAALPLHPWQAEDIGQRPAASALLDAGLLHDLGPHGELWYPTSS
                     VRTVHRPGAPAMLKLSLGLRITNSRRENLRKELHRGVEVHRLLRAGLAEQWRAAHPRFD
                     IVRDPAWLAVDTPDAEPLPGLDVMIRHNPFGSGDDAVCIAALTAPRPWPGQAGMRSRLS
                     LTVERLAARTGRPVPAVAAEWFLRYLDHVVRPVLWLDATAGVALEAHQQNTIVLLDPDG
                     WPTGGRYRDNQGYYFRESHRERLDDRLPGIGTHSDTFVSDDVTDERFAYYLGINNVLGL
                     IGAFGAQRLADERVLLAGLRRFLASAAAMGSPLPGQLLETPTLRCKANLLTRLQGLDEL
                     VGPVDTQSVYVTIANPLRS"
     gene            6633..7397
                     /locus_tag="IE198_RS19635"
                     /old_locus_tag="GCM10010381_39710"
     CDS             6633..7397
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203: putative siderophore biosynthesis protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018535931.1"
                     /locus_tag="IE198_RS19635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39710"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_189888365.1"
                     /transl_table=11
                     /translation="MPPTDTHTDSGLGPAPRPGGGAEDTLDLRLPDDFLALIHENDSCL
                     STTRTPTGHRSQTWVDAFAGDLLDDLGAWCPRDTRAGTFQLVPVVLERDLALITRWMND
                     STVAAFWELAGPDLVTADHLRAQLEGDGRSVPCLGVLDDTPMSYFEIYRADLDPLARHY
                     PARPHDTGVHLLIGDVANRGRGVGSVLLRAVSDLVLDKRPLCMRVIAEPDLRNTPSVSA
                     FLSSGFRLSAEIDLPDKRAALMVRDRALRSLL"
     gene            7457..9313
                     /locus_tag="IE198_RS19640"
                     /old_locus_tag="GCM10010381_39720"
     CDS             7457..9313
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105326.1"
                     /locus_tag="IE198_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39720"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_373299901.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.7e-72, bitscore:
                     237.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKSPASHDSVPLVPPGLTRRNWDRAAARLLAKMLGEFAYEEIIE
                     PVRAHPDRPATTAGGDLYALPVEGNSAFTFRARRGAYGSWRVVPGSVRCEDRPFSDPLA
                     FLALAKDLLGLDGATLGHLLREMSFTLTGDTRLDGTALSAAELADLGYAELEGHQTGHP
                     WLVLNKGRIGFSATDAARWAPEARRPVCLPWIAVKTGLAAYRGVPGLDAQDLYSRELDE
                     PTRESYAGALRAKGLDPAEYLFLPVHPWQWDEVLLPLYAPAVARDEIVPLPSDGDLRLP
                     QQSIRTFVNVDRPDRHTVKLPLSILNTLVWRGLPTERTLAAPAVTSWVQGLRDADPFLR
                     DECRVVLLGEVASVTVEHPLYDHLAEVPYQYKELLGAIWREPLQPRLDAGERARTLASL
                     LHTDPHGRAFTAELVTRSGLAPTVWLQRLFAALLPPLLHFLYRYGTVFSPHGENAIVIY
                     DDHDVPVRLAIKDFVDDVNVSAQPLPEHASMPKEVRRILLTEEPGFLTQFIHSGLFVGV
                     LRYLAPLCEDQLDVPEEKFFSLVREEILRHHARFPELKERYEAFDLLTPRIERLCLNRN
                     RLHLDGYRDRPERPHAAVHGTVPNPLAPSDGPLPDPVVGGAP"
     gene            9326..11296
                     /locus_tag="IE198_RS19645"
                     /old_locus_tag="GCM10010381_39730"
     CDS             9326..11296
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018520798.1"
                     /locus_tag="IE198_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39730"
                     /product="ATP-dependent DNA helicase"
                     /protein_id="WP_189888367.1"
                     /transl_table=11
                     /translation="MTKPSLPDLLHAAVTAVGGVERPGQVTMAEAVAEAIDDDSHLLVQ
                     AGTGTGKSLGYLVPALAHGERVVVATATLALQRQLVERDLPRTVEALHPLLRRRPEFAM
                     LKGRSNYLCLHRLHEGVPQDDEDGLFDQFEAAAPTSKLGQDLLRMRDWADETETGDRDD
                     LTPGVSDRAWSQVSVSSRECLGASKCAYGAECFAEMARERAKLADVVVTNHALLAIDAI
                     EGAPVLPQHEVLIVDEAHELVSRVTGVATGELTPGQVNRAVRRAAKLVDEKAADALQTA
                     AETFERLMELALPGRLEEIPEDLGYALMALRDAARTVITAIGSTRDKSVQDEDAVRKQA
                     LAAVESVHAVAERITHGSEYDVVWYERHDRFGASLRVAPLSVSGLLREKLFAERSVVLT
                     SATLKLGGDFNGVGASLGLAPEGSGGEEVPQWKGMDVGSPFDYPKQGILYVARHLATPG
                     REGSRGDMMDELAELVEAAGGRTLGLFSSMRAAKAAAEELRGRLGNPILLQGEETLGEL
                     IKSFAADPETCLFGTLSLWQGVDVPGPGCQLVVMDRIPFPRPDDPLMSARQKAVEEAGG
                     NGFMAVAATHAALLMAQGAGRLVRATGDRGVVAVLDPRLANARYGSYLRASLPDFWYTT
                     DRNQVRRSLAAIDAAAKAEGK"
     gene            complement(11495..12280)
                     /gene="lexA"
                     /locus_tag="IE198_RS19650"
                     /old_locus_tag="GCM10010381_39740"
     CDS             complement(11495..12280)
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965791.1"
                     /locus_tag="IE198_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39740"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_189888369.1"
                     /transl_table=11
                     /translation="MTTTADSATITAQDRSQSRFESVHAMNDAATTPEGPKPGRSLPGR
                     PPGIRADSSGLTDRQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQLMALER
                     KGFLRRDPHRPRAYEVRGSDQPSTQPTDTTGKPAASYVPLVGRIAAGGPILAEESVEDV
                     FPLPRQLVGDGELFVLKVVGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMLDGEATVK
                     RFKRENGHVWLLPHNAAYQPIPGDEATILGKVVAVLRRV"
     misc_feature    complement(12342..12357)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.09"
                     /tool="antismash"
     misc_feature    12343..12356
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.93"
                     /tool="antismash"
     misc_feature    complement(12343..12356)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.77"
                     /tool="antismash"
     misc_feature    complement(12353..12366)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.92"
                     /tool="antismash"
     misc_feature    complement(12366..12378)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     misc_feature    12633..12646
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    complement(12664..12678)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 24.78"
                     /tool="antismash"
     misc_feature    complement(12695..12709)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.26"
                     /tool="antismash"
     misc_feature    complement(12723..12737)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            12819..13331
                     /gene="nrdR"
                     /locus_tag="IE198_RS19655"
                     /old_locus_tag="GCM10010381_39750"
     CDS             12819..13331
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0140110 - transcription regulator activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="nrdR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956102.1"
                     /locus_tag="IE198_RS19655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39750"
                     /product="transcriptional regulator NrdR"
                     /protein_id="WP_189888371.1"
                     /transl_table=11
                     /translation="MHCPFCRHPDSRVVDSRTTDDGTAIRRRRQCPDCARRFTTVETAS
                     LMVIKRSGVTEPFSRTKVISGVRKACQGRPVTEDALAQLGQRVEEAVRATGSAELTTHD
                     VGLAILGPLQELDLVAYLRFASVYRAFDSLEDFEAAIAELRAGRPPAEAGGGGGAVEVP
                     VPATAAD"
     gene            13500..16376
                     /locus_tag="IE198_RS19660"
                     /old_locus_tag="GCM10010381_39760"
     CDS             13500..16376
                     /EC_number="1.17.4.1"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030467.1"
                     /locus_tag="IE198_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39760"
                     /product="vitamin B12-dependent ribonucleotide reductase"
                     /protein_id="WP_189888373.1"
                     /transl_table=11
                     /translation="MTETTSGPARGSRAKGSKANKGLRIERVHTTPGVHPYDEVVWERR
                     DVVMTNWRDGSVNFEQRGVEFPDFWSVNAVNIVTSKYFRGAVGTPQRETGLKQLIDRIV
                     KTYRKAGEDHGYFASPADAEIFEHELAYALLHQIFSFNSPVWFNVGTPQPQQVSACFIL
                     SVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADAS
                     AGTIKSGGATRRAAKMVILDVDHPDIEGFIETKVKEEEKIRALRDAGFDMDLGGDDITS
                     VQYQNANNSVRVNDEFMKAVEAGGKFGLRARMTGDVIEEVEAKSLFRKMAEAAWACADP
                     GIQYDDTINRWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDGKGNQSFD
                     VERFSKIVELVITAMDISICFADFPTRKIGENTRAFRQLGIGYANLGALLMATGHAYDS
                     DGGRALAGAITSLMTGTSYRRSAELAAVVGPYDGYARNAEPHKRVMKQHADANAVAVRM
                     DDLDTPVWAAATEAWQDVIRLGEKNGFRNSQASVIAPTGTIGLAMSCDTTGLEPDLALV
                     KFKKLVGGGSMQIVNGTVPQALRRLGYQPEQIEAIVAHIADHGNVIDAPGLKAEHYEVF
                     DCAMGERSISAMGHVRMMAAIQPWISGALSKTVNMPESATVEEVEEIYFEAWKMGVKAL
                     AIYRDNCKVGQPLSAKKKEKAEVAGKAEETIRAAVEKVVEYRPVRKRLPKGRPGITTSF
                     TVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVS
                     KFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLET
                     GSYEPTDDELDVEGLAQSAPVQQELKAVAAPKAEIPAPQQAHTSAELVEMQLGISADAP
                     LCFSCGTKMQRAGSCYICEGCGSTSGCS"
     gene            complement(16458..16877)
                     /locus_tag="IE198_RS19665"
                     /old_locus_tag="GCM10010381_39770"
     CDS             complement(16458..16877)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024092.5"
                     /locus_tag="IE198_RS19665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39770"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_189888375.1"
                     /transl_table=11
                     /translation="MAETENTRLMQHIFAGLMKGDGRPLAESLADDFRWTIIGTTKWSG
                     TYEGKQAVLDDLFRPLLAQFADIYTNTPQRFIAAGDCVVVECSGRATTTEGKPYNNTYC
                     WVCHIKEGKLQALTEYCDTDLIARALGEPGDRKPR"
     gene            complement(17003..17830)
                     /locus_tag="IE198_RS36380"
                     /old_locus_tag="GCM10010381_39780"
     CDS             complement(17003..17830)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014404.5"
                     /locus_tag="IE198_RS36380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39780"
                     /product="TerD family protein"
                     /protein_id="WP_308426834.1"
                     /transl_table=11
                     /translation="MSARRDHHDGPAYQPLFDRLESAQRILVALMSICFVFPLAGTARR
                     CPYVDRIENTHLIRQVSSEIEAFRDEVVRQRPHPARNGYRQRTYSFRQLRGRKSVNSLN
                     KGVRKAEVALRWDPSPLGESPHDLDLVAATYSAEAPFGEPAYVVHFDSRSPDGTIILAR
                     ESRTGQGFGADEVMTLEFDRLAARYGRVVVGVVIQQGDGRTVFGDVVNASVRVLEGHRE
                     IGRHDFTAVPDATAATIGEFVRGEAGGWTFSGRLLGFDGDPQTYLTVMGDPAR"
     misc_feature    complement(17549..17551)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17936..18541
                     /locus_tag="IE198_RS19675"
                     /old_locus_tag="GCM10010381_39790"
     CDS             17936..18541
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1258: Antibiotic biosynthesis monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385166.1"
                     /locus_tag="IE198_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39790"
                     /product="YdbC family protein"
                     /protein_id="WP_189888377.1"
                     /transl_table=11
                     /translation="MLVKWIRCTVVDRRGFERGQRKWAGLLGEPGFRGQGGGWSRIRPN
                     VAHVFAFWETRAFYDSFMARSHDRLASGQAGTYKDSQAKLFDHRFDVKTGFEPRFTESD
                     VVRVAHCRVREDRVEHFSLMQEKVWNPAMAGSPGMVRGVFGEAPGNEFLVMSMWLSAAE
                     HGKYRAERVERLLLRAQTAADVAALAGDVVALEPSWTV"
     gene            18588..19247
                     /locus_tag="IE198_RS19680"
                     /old_locus_tag="GCM10010381_39800"
     CDS             18588..19247
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965783.1"
                     /locus_tag="IE198_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39800"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_189888380.1"
                     /transl_table=11
                     /translation="MARPRRIVLVRHGESVGNADDTVYEREPDHALPLTAAGLAQAAET
                     GARLRELFGRERVSVYVSPYRRTLETFRAFGLDPGLVRIREEPRLREQDWGNWQDREDV
                     RLQKAYRDAYGHFFYRFAQGESGADVYDRVGAFLESLHRSFVAPDHPPNVLLVTHGLTM
                     RLFCMRWFHWSVAEFESLSNPANGETRTLQLGEDGRYHLDRPFERWRTPEPYGATG"
     gene            19260..20174
                     /locus_tag="IE198_RS19685"
                     /old_locus_tag="GCM10010381_39810"
     CDS             19260..20174
                     /EC_number="3.2.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311050.1"
                     /locus_tag="IE198_RS19685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39810"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_189888381.1"
                     /transl_table=11
                     /translation="MTADSASDPRFVRALDSLRGLSVGDALGSQFFVPSNYPLLKRREL
                     PPSVWQWTDDTEMACSVLAVLVEHHRVDQDALARSFAEHHDFDRGYGPAVNRLLRLIRQ
                     GGDWRELSAELFKGQGSWGNGSSMRIAPLGAWYADDPEQATHQAEISSYPTHQHREAVV
                     GAMAVAAAAALAANPAGPPGPAELLDGVIALVPRSAVGAGLRRAVDMLDYNDPGTVAAV
                     LGSGRRTSAHDTVPFALWSAARSLGDFEQAFWTTAQVGGDVDTTCAIACGVVAASKAGQ
                     PPAHWLERTEQLPDWLPGADRAG"
     gene            complement(20272..21825)
                     /locus_tag="IE198_RS19690"
                     /old_locus_tag="GCM10010381_39820"
     CDS             complement(20272..21825)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311049.1"
                     /locus_tag="IE198_RS19690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39820"
                     /product="MFS transporter"
                     /protein_id="WP_373299908.1"
                     /transl_table=11
                     /translation="MTTSQLRAPVPPGAARRQGRPGIALAVIAALQLMVVLDTTIVNIA
                     LPHIQGALEFTTTQLSWVVNAYTLTFGGLLLLGGRAGDILGRRRVFVSGVLLFTFASLL
                     CGIAQEPWQMLAARALQGVGGAIASPTALALITTTFREGPERNRAFGIFAAVSASGAAI
                     GLLAGGMLTEWLDWRWVFYVNLPIGILIAALAPVFINESERHPGRFDVAGALTSTVGMA
                     SLVYGFIRASEDGWSDELTLGAFAAAVVLLTAFVLTERKARDPITPLRMFADRNRSGTY
                     LIMMSLAAAMFGMFFFIVLFVQNVLDYSPITSGLAFLPVTVMIVIAAGLSSKLLPVLGP
                     KPFLTAGALFTGSGMAWLTFISPDSSYVAAVLWPMLLFGFGMGLVFVTATLTAVSGVAQ
                     HESGAASSLLNATQMVGGSLGLSILMTVFGTASRDEAERQLPSFLAEATPAQQEAFARS
                     HELPPPWGHQVLAEGIATALWAGVGLVALAVVAALFVIRVRKSDLEALSGAAGPGGHAA
                     "
     misc_feature    complement(21860..21871)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    21866..21880
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.91"
                     /tool="antismash"
     misc_feature    21894..21905
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            21947..22594
                     /locus_tag="IE198_RS19695"
                     /old_locus_tag="GCM10010381_39830"
     CDS             21947..22594
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009298468.1"
                     /locus_tag="IE198_RS19695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_39830"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189888385.1"
                     /transl_table=11
                     /translation="MATSRRTGATEAPSAPLRRRGPVLERAILEAALELLGTVGWSGFT
                     MEGVAAGAQTGKAAVYRRWPSKEDLVADALEAGLPPLDQDADQGGVREDLFHVCRRVRD
                     AMFSRTGVALRSVLHECDAVAAERFQGLIVNRVVEPSKELFRAVVRRGVSRGDVRPDAA
                     CELVLDVIPGLLMYRSKVCGSEWPDTDIAQMIDQVMVPLLRPHSCRPIDGGS"
ORIGIN
        1 ccccggccgg ggcgggcctt tcgccgtgct cagaagccgg gcctactggc ccgcgaactt
       61 gtcgctcatc atcgtgtaga tctgctgcgc gccctgatcg agccgcggac cggccagcca
      121 gccagaagtg acggggccga tggaggtgtt ggagaccagc gccagcttgc cgttcggttg
      181 ctcggcgaac cagccgccgc cggaggaacc gccggtcatg gtgcagccga tacgccacat
      241 ggtcggagtg ccgggagcga tggacagccg gccgggccgg tcgacgcact tgtgcatcag
      301 cgcaccgtcg tacggcggcg cggccgggta accccaggcg cccatggcgc tgatgtcctt
      361 cgcctcggga gcgtcgaagt cgatgtcgag ggcgacgccc accgtctcct cgagggactt
      421 ggtgccctgc tcgggcttca catgcatcac ggcgtagtcg tacggggcgc cggtgccgcc
      481 cgtcgggccg ccctcatcga tccactcgcc ggacgtcgcg acccagtccg cccagtagac
      541 gccgtagggc gcgacctcgt gcggctgcgc gttctccagt gcggccgggg acttgccctg
      601 gtcgttgtag gcggggacga aggcgatgtt gcggtaccaa ccgccggccc ggcccgcgtg
      661 gacgcagtgg ccggccgtcc acacgaggtt ggacctgccg gggttcttcg ggtccttgac
      721 gacggtcgcg gagcagacca tcgagccctc gggggcgtcg aagaagacct tgcccacggg
      781 ggcggcgttc ttgtggtacg gcttcttctc cggctccgcc cggaccgggc gcggctcggg
      841 atcggtgacg ccctggtcac cggagatgtc gccggcggcc atcgtcttcg ccggcgcctt
      901 ggccgtcgtc atccgctcag gcttccacag gccctcgatc accgggttga cgaagtcctt
      961 ggcctcacgc agccacttgt ccttgtccca gttcttccac tcgccgttct tccactggtc
     1021 caggtcgaca ccgcgctcct tgagcttgtc ggccaggtcc gcagggaccg cggcgccacc
     1081 gttgtcagcg gccgggctgg acgcggccgg tttgtccgcc gcgtcgttct cgctcgggcc
     1141 gcaggcggtc gccgtcaggc cgagtgccgt gacgagaccg gccgcggcca gcagtggacg
     1201 tatggatcgc atgggacgat tccccctgaa gtgctcagta cttgccatgg aaacagctgc
     1261 ttgccatgaa cttgtcatgg gaaaaggcgg ccgtcggggg ccgcctcacg ctgcgccacc
     1321 actctaggcg ctgcgcacgg acgatcatcc tggacgggcc ctgctcaccc tcaactgcac
     1381 ggactctcca cgaggatggc gagccgaagg gggcgcgcgg gtgtcgaaag ggagtggggg
     1441 caccacccgc cagggcaggg ggagcgcgcc gatcccgagg aacgagggat cgagcgcgat
     1501 cgaccgtcga cacacgcaca aagcgcccgg aggcgaaccg ggcgagaacg acgcagaagg
     1561 gcgaagcgca agggtctcgg ccttacggtc gagacccctc cccgcatcac ttcatgcgga
     1621 cgcccgtgcg cacggctccc ttgcctcttc ggcggtcact gtcccgcgaa cttcttgctg
     1681 accgcgttgt agacgccctc ggcgtcctta ccgaggcgcg gacctgccag ccagcctgcc
     1741 gtaaccgggc cgatggaggt gttggagacc agggccggct tgccgtcctg cccctgcgcg
     1801 acccagccac cgccggacga accgccggtc atggtgcagc cgatgcggta catcgtcggc
     1861 tcatcggcgt tcagcgacag ccggcccggc ttgtcggcgc actggaagag cttctggccg
     1921 tcgtacggcg gagccgccgg gtaaccggtg gcggtcatgt tcgcgatctt cggcaccgca
     1981 ggggcgttga agtcgaccgg cagggccgaa ccgaccgtct cctcgaggga cttgccgttg
     2041 ccgcccttct ccggcgtcac gtggatgacg gcgaagtcgt aggccgcgcc ctggccgccg
     2101 gtcgcggcgc cctgggagat ccactggtcg gaggtctgcg cccagtcgcc ccaccagaca
     2161 ccgtagggag cgatctcctc cttgggtgcc ttctccagct ccgcggtctc cttggccccg
     2221 tcgttgtacg aggggacgaa ggcgatgttt cggtaccagc cgccactctt accggcgtgc
     2281 acacagtggc cggcggtcca caccatgttg gacttgccgg gattggccgg gtccttgacg
     2341 acagtcgcgg aacagaccat cgaaccctgc ggaccgtcga agaagacctt gccggcctcc
     2401 gcggcgttcg cgtggtacgg ggccttcacg gcctgggcgt cgaccggcgc gggagcaggg
     2461 tcggtgacgc cttcgtcgcc cgagatgtca ttgtcgaccg gcttctccgg gggcttgtcg
     2521 gcatcccgca tccggtccgg gtcccagagg tcctcgatga tcgggttgac gaagtcctgg
     2581 gcctcacgca gccacttgtc cttgtcccag ttcttccact cgccgttctt ccacttgtcc
     2641 aggtcgatcc cgtgctcctt gagccggtcc ttgagatcgt ccgggatggt gatcttgccg
     2701 tcggcggact ggctggccgg cgcgctcggc ttgtcgccgg cgctgtcctc gctcgggccg
     2761 cacgcggtgg cggcaagcgc cagcactgcg gctatcgatg ccgctgccag cgtcgggcga
     2821 atgggtcgca tctcttgatc cccctgggac ttcggtggtg ctgatctgtc gaactgtgct
     2881 gctgagctgt tgaaccgagt tgttgaacag agttgttgaa ctgtcggagt tgtgcaggaa
     2941 cttctggaac gagcaagtcc ccggccgatc cggtggaact cgtcagccgg agtgcagccc
     3001 cccactatgc cggtgccgtt ggggacggcg tgcggcaggt ccttggttcc ggaggcgcaa
     3061 ggatcttccg tatgcccgtg atccccggcc ctccgcgtcg ttggaaagtg cgggggacac
     3121 aaggacagcc tccagcgccg gtgcgccgcg cagaagtgac gtaccgatgt gcaacgcaac
     3181 cgtgacagcc ggaggacgaa cagccgtggc cgtgaccgaa cctgctccgg tggcgccgac
     3241 cgcagctcat gaggggattc tgcgcagaca gtcgctccgc gagtccgctg cccgcaccta
     3301 tgcgcgctca ctgcccatcg tgccggtccg ggccaggggg ctgacgatcg aaggagccga
     3361 cgggcgccgg tatctcgact gcctctccgg cgctggcacc ctggcgctcg ggcacaacca
     3421 ccccgtcgtc ctcgaagcga tcaagaaggt catcgactcc ggcgctccgc tgcacgtgct
     3481 ggacctcgcc acacccgtca aggacgcttt catcaccgag ctgttcgcca cgctcccgcg
     3541 gccgctggcc gaggacgcgc gcatccagtt ctgcggtccc gcgggcacgg atgccgtcga
     3601 agccgcgctc aagctcgtca ggaccgccac cggccgcagc ggcctgctgg ccttcaccgg
     3661 cgcctaccac ggcatgacgg ccggagcgct cgaagcctcc ggcggcgcca cggacgtacg
     3721 ggtcacccgc ctcccgttcc cgcacaacta ccgctgtccc ttcgggatcg gcggcgagcg
     3781 cggcgcggag ctcgccgccc gctggacgga gagcctgctc gacgacagca agagcggcgt
     3841 tccgacgccg gccgccatga tcctcgagcc cgtgcagggg gagggcggag tgattccggc
     3901 ccccgacgag tggctgcgca ggatgcgagt tctgaccgcc gcccgctcca ttccgctgat
     3961 cgccgacgag gtgcagaccg gagtgggccg caccggcacc ttctggggcg tcgagcacag
     4021 cggagtcgta ccggatgtca tggtgttgtc caaggccatc ggcggttccc ttccgctcgc
     4081 cgtcgtcgtg taccgctccg aactcgacgc ctggcccccc ggggcccacg cgggcacctt
     4141 caggggcaac caactcgcca tggctgcggg tgccgccacg ctcgcccacg tccgtgagaa
     4201 cgctctcgcc gagcgcgcag ggacgctcgg cgcccgcatg ctggcctccc tgcagggcct
     4261 cgccgcggcc cacccctgca tcggtgacgt acgcggccgg gggctgatga tcggcgtcga
     4321 actcgtcgag cccgactcca tggcacccga cgcagtcgtc ccccctccgg caccccagct
     4381 cgcggcagcc gtgcagcagg agtgtctgca ccgcggcctc atcgtcgagc tgggcggacg
     4441 ccgggccggt gtcgtacgcc tgctgcctcc tctcaccctg accgatgaac aagccgtggc
     4501 cgtcctcgac cgcttcgccg acgccctggc cgccgcagag cgctccacac aacgccgcac
     4561 cgacaacagg cagtcgcaca acaggcagtc gaactgaccc cggacaacgt cacaagggag
     4621 ccctccgtga accccattcc cgtacccgat gcgcccgagt cccacgacgg ccccgccggc
     4681 caccaccgcg acacgtgtgg agcgagcggc cccctcacga tggagcccgt gacggtgcca
     4741 cgtcagcccg ggcgcctcga cgaacagcgc ggcggtcgcg cgggcacgct cgcgcaggcc
     4801 gacggccccg gccggcccgg cgcagagacg gaccgcctcg accaccgcgc ccatcacggc
     4861 ccggtggacc accgggaccc gctcgacgac ctcgacgagc gccgtgccgc ggacacggcg
     4921 accgtggaga acctcctgcg ctgctgggtg cgggagaacg acctgacccg gcccgaggga
     4981 cacaccctgc gtattccgct cgacgccagc ggcaccgcgc tgctggtccc cgtgcactac
     5041 tggtccgcca ccggatggca ccgtttcgga gctcccgccc tggaggggag ctcgcgcgag
     5101 gccacacggg ccgacgcggt gaccgtcgcc gcgctcctcg gccgtgaagc cggccacgcc
     5161 gaaggaaccg atctcgtggc ccgggtcgcc gactccgtcc gccgcacggc cggcttcatc
     5221 gccgaccggc gagagcgccc cgctgccccg cccgaggcgg acctgtttct caccgccgag
     5281 cagtccctgc tgctcggcca ccccctccac ccgacaccga agagccgcga aggactctcc
     5341 gacgccgaag cacgcagcta ctcgccggag ttgtacggct ccttccgatt gcactggatg
     5401 gctgtcgaca agtccgtcct ggccgccgaa tccgcctgga cagaacaggg ccgcgccgtc
     5461 acggccgaac agctcacctc ccgtctcgcg ggagacctcc cgctccccga caacaccgct
     5521 gccctgccgc tgcacccatg gcaggccgag gacatcggac agcgccccgc ggcatccgcc
     5581 ctcctggacg ccggtcttct gcacgacctc ggccctcatg gcgaactctg gtaccccacc
     5641 tcctccgtcc gtacggtgca ccgccccggc gccccggcca tgctcaaact ctccctcggc
     5701 ctgcgcatca ccaactcccg ccgggagaac ctccgcaagg aactgcaccg aggagtcgag
     5761 gtgcaccgac tgctccgcgc cggcctcgcc gagcaatggc gggccgccca cccccgcttc
     5821 gacatcgtgc gcgacccggc ctggctcgcc gtcgacaccc cggacgccga acccctgccc
     5881 gggctcgacg tcatgatccg ccacaacccc ttcggctccg gcgacgacgc ggtctgcatc
     5941 gcggcgctga ccgccccccg cccctggccc gggcaggcgg gcatgcgctc gcgtctctcc
     6001 ctcaccgtcg agcggctcgc ggcccggacg ggcaggcccg ttcccgcagt ggccgcggag
     6061 tggttcctgc gctatctcga ccatgtcgtg cgccccgtgc tgtggctgga cgccacagca
     6121 ggcgtcgccc tcgaggccca ccagcagaac acgatcgtgc tgctggaccc cgacggctgg
     6181 ccgaccggtg gccgttatcg ggacaaccag ggctactact tccgcgagtc ccaccgcgag
     6241 cggctcgacg accgcctccc gggtatcggg acgcacagcg acaccttcgt ctccgacgat
     6301 gtcaccgacg agcgcttcgc ctactacctc ggcatcaaca acgtgctcgg tctgatcgga
     6361 gccttcgggg cgcagcgcct cgccgacgag cgtgtcctcc tcgccggcct ccgccgtttc
     6421 ctcgcatccg cggccgccat gggctcacca ctgcccggtc agttgctcga gacgcccaca
     6481 ctccgctgca aggccaatct gctcacccgg ctgcagggac tcgatgagct cgtcggcccc
     6541 gtcgacaccc agtccgtcta cgtcaccatc gccaatcccc tccgatcctg agcctgcaac
     6601 ccgcataccg aaccgcgaga ggagacgccg cattgcctcc caccgatacg cacaccgaca
     6661 gtgggctcgg ccctgctccc cggcctggag gaggtgctga ggacacgctc gacctgcggc
     6721 tcccggacga cttcctcgcc ctgatccatg agaacgacag ctgcctgtcc acgacgcgaa
     6781 cgcccaccgg ccaccggtca cagacctggg tcgacgcctt tgccggcgac ctgctcgacg
     6841 acctcggcgc gtggtgcccg agggacacac gcgccggcac cttccaactc gtccccgttg
     6901 tcctcgaacg tgatctcgcg ctgatcaccc gatggatgaa cgactccacc gtcgccgcct
     6961 tctgggagct ggcgggaccc gacctcgtca ccgccgacca cctgcgcgca caactcgagg
     7021 gcgacggccg cagcgtcccc tgcctcggcg tcctcgacga cacacccatg agctatttcg
     7081 agatctaccg agccgatctc gatccgctcg cccgtcacta cccggcgcgc ccgcacgaca
     7141 cgggcgttca cctgctcatc ggcgatgtcg cgaaccgggg ccgcggcgtc ggctccgtcc
     7201 tccttcgcgc cgtgtccgac ctcgtgctcg acaagcggcc tctgtgtatg cgggtcatcg
     7261 cggaacccga cctgcgcaac accccctccg tctccgcgtt cctcagctcc ggattccggc
     7321 tctccgccga aatcgacctt cccgacaagc gagccgccct catggtccgg gaccgcgccc
     7381 tgcggagcct gctgtgaacc acccgctgta ttgcatacac cgctcgatcc gcatcggttc
     7441 cacccgagga gtccccgtgc cgaaatctcc cgccagccac gactccgtcc ccctcgtccc
     7501 gcccggtctg acccgccgga actgggaccg ggcagctgcc cgactgctcg ccaagatgct
     7561 cggtgaattc gcgtacgagg agatcatcga gccggtccgg gcccatccgg accgcccggc
     7621 aacgacggcc ggcggcgacc tctacgccct ccccgtcgaa gggaacagcg cgttcacctt
     7681 ccgggcccgg cgaggagcct acggaagctg gcgcgtcgtc cccggctccg tccgatgcga
     7741 agaccggccc ttctccgacc cgctcgcctt cctcgcgctg gcgaaggacc tgctcggcct
     7801 cgacggagcc accctcggcc atctgctgcg tgaaatgtcc ttcaccctga ccggcgacac
     7861 ccggctcgac ggcaccgcgc tgagcgccgc cgagctggcc gacctgggat acgccgagct
     7921 cgaaggccac cagaccggcc acccgtggct ggtcctcaac aagggacgca tcggcttctc
     7981 cgccaccgac gccgcgcgct gggcacccga ggcccgccgc cccgtgtgcc tgccctggat
     8041 agcggtcaag accggtctcg cggcctaccg cggcgtcccc ggcctcgacg cgcaggacct
     8101 ctacagccgc gagctcgacg aaccgacccg cgagtcctac gccggcgcgc tgcgcgccaa
     8161 gggcctggat cccgccgagt atctgttcct gcccgtgcac ccgtggcagt gggacgaagt
     8221 gctgctgccc ctgtacgcac ccgctgtggc ccgcgacgag atcgtcccgc tgcccagcga
     8281 cggcgacctg cgactgcccc agcagtccat caggacgttc gtgaacgtcg accggccgga
     8341 ccgccacacc gtcaagctgc cgctgtccat cctgaacacc ctggtctggc gggggctgcc
     8401 caccgagcgg actctcgcgg ctcccgccgt cacctcctgg gtgcagggac ttcgtgacgc
     8461 cgaccccttc ctgcgcgacg agtgccgggt cgtcctgctc ggcgaggtcg cctccgtgac
     8521 cgtcgagcat ccgctgtacg accacctggc cgaggtgccc taccagtaca aggaactgct
     8581 cggcgcgatc tggcgggagc cgctccagcc gcgactggac gcgggtgaac gggcccgcac
     8641 cctcgcctcg ctcctccaca ccgatccaca cggccgggcc ttcaccgccg aactcgtcac
     8701 ccggtccggc ctcgccccca cggtctggct ccaacggctc ttcgcggctc tgctgccgcc
     8761 actgctgcac ttcctctacc gctacggcac ggtcttctcc ccgcacggcg agaacgccat
     8821 cgtgatctac gacgaccacg acgttcccgt ccgcctcgcg atcaaggact tcgtcgacga
     8881 cgtgaacgtg agcgcacagc ccctgcccga gcacgcctcg atgccaaagg aggtgcggcg
     8941 gatcctcctc accgaggagc caggcttcct cacccagttc atccactcgg gtctcttcgt
     9001 gggggtgctc cgctatctcg ccccgctctg cgaggaccaa ctggacgtgc ccgaggagaa
     9061 gttcttctcg ctcgtacggg aggagatcct gcgccaccac gcacgcttcc ccgagctcaa
     9121 ggagcgctac gaggcgttcg acctgctcac cccacgtatc gagcgcctgt gcctcaaccg
     9181 caaccgactc catctcgacg gctatcgcga ccgccccgag cgcccgcacg cggccgtcca
     9241 cggcaccgtt cccaacccct tggcgccgtc ggacggcccg ctgcccgatc cggttgtcgg
     9301 tggcgccccg tagggtggtc gggctatgac gaagccatcc ctccccgacc tcctccatgc
     9361 cgccgtgacc gccgtcggcg gtgtggagcg gccaggccag gtcaccatgg ccgaggccgt
     9421 tgccgaggcc atcgacgacg attcccacct gcttgtccag gccggcaccg gtacgggcaa
     9481 gtcgctcggc tatctcgtcc cggccctcgc ccacggcgag cgtgtggtgg tggcgacggc
     9541 gaccctggcg ctgcagcgcc agctcgtgga gcgtgatctt ccgcgtacgg tcgaggcgct
     9601 gcatccgctg ctgcgacgcc gacccgaatt cgcgatgctc aagggccggt cgaactacct
     9661 ctgcctgcac cgcctccacg aaggcgtgcc gcaggacgac gaggacggac tcttcgacca
     9721 gttcgaggcc gcggcgccca cgagcaagct cggtcaggac ctgctgcgca tgcgggactg
     9781 ggccgacgag acggagaccg gtgacaggga cgacctgacc ccgggcgtgt ccgaccgcgc
     9841 ctggagccag gtctccgtgt cctcccgtga gtgcctgggt gcttccaaat gcgcctacgg
     9901 agcggagtgc ttcgccgaga tggcgcgcga gcgggccaag ctcgcggacg tcgtggtcac
     9961 caatcacgcc ctgctcgcga tcgacgccat cgagggcgcc ccggtgctgc cgcagcacga
    10021 ggtgctgatc gtcgacgagg cgcacgaact ggtctcccgt gtcaccggcg tcgccacggg
    10081 cgagctcacc cccgggcagg tcaaccgtgc tgtccgacga gcggccaaac tcgtcgacga
    10141 gaaggcggcc gacgcactcc agacggccgc ggagaccttc gagcgcctta tggagctggc
    10201 cctccccggt cgtctggagg agatcccgga agacctgggc tacgccctga tggcgctgcg
    10261 ggacgcggcc cgcacggtga tcaccgcgat cggctccacg agggacaagt ccgtccagga
    10321 cgaggacgcc gtgcgcaagc aggccctcgc cgccgtggag agcgtgcacg cggttgccga
    10381 gcggatcacc cacggctccg agtacgacgt ggtctggtac gagcggcacg accgcttcgg
    10441 ggcgtccctg agggtcgcac cgctctccgt ctcagggctg ctgcgggaga agctcttcgc
    10501 ggagcggtcg gtggtgctga cctcggccac gctcaaactc ggtggcgact tcaacggggt
    10561 gggggcctcc ctcggcctcg caccggaggg cagcggggga gaggaggtgc cgcagtggaa
    10621 gggcatggac gtcggatcgc ccttcgacta tcccaagcag ggcatcctgt acgtcgcccg
    10681 gcatctcgcc acacccgggc gcgagggttc caggggcgac atgatggatg agctcgccga
    10741 actggtggag gccgccggag ggcgtactct cgggctcttc tcctcgatgc gggccgcaaa
    10801 ggcggcggcg gaggaactgc gcggccgcct cggcaacccg atcctgctgc agggcgagga
    10861 gaccctcggc gagttgatca agtcgttcgc cgcagacccg gagacctgtc tgttcggcac
    10921 gctctcgctc tggcagggcg tcgacgtgcc cggtcccggc tgtcagctcg tcgtcatgga
    10981 ccgtattccg ttcccgcggc cggacgaccc gctgatgagc gcacggcaga aggccgtcga
    11041 ggaggcgggc ggcaacggct tcatggccgt ggcggcgacg catgcagcac tgctgatggc
    11101 tcagggagcg ggccggctgg tccgggccac cggggaccgg ggagtggtgg cggtgctcga
    11161 tccgcgtctc gccaatgcgc gctacggcag ttatctgcgc gcctcgctgc ccgacttctg
    11221 gtacaccacg gaccgcaacc aggtgcgccg ctcactggcg gccatcgacg cggcggcgaa
    11281 ggcggaggga aagtagcgcc ggaggccaac gcggaggaga gcggtgcgga ggtccagacg
    11341 gaggaagcag ctccgggagg caaacggcgc cggaagggca ttcgacgccg ctgcgtccgg
    11401 gagtcgctct gcgcccgaag cccgcgtgca gacaacgcag gaccccggga ccggcgcagt
    11461 ggatcccggg gtccggtctg ggccggcggg tgtttcacac ccgccgcagc accgccacca
    11521 ccttgccgag gatggtcgcc tcgtcgccgg ggatgggctg gtacgcggcg ttgtgcggga
    11581 gcagccagac gtggccgttc tcccgcttga agcgcttgac cgtggcctcg ccgtcgagca
    11641 tggcggccac gatgtccccg ttctccgcca cgggctggcg tcgcacggtc acccagtcgc
    11701 cgtcgcagat cgcggcctcg atcatcgagt ctccgacgac cttcagtacg aagagctcac
    11761 catcgccgac cagctggcgg gggaggggga agacgtcctc gacggactcc tcggcgagga
    11821 tgggtccacc tgccgcgatc cggccgacga gggggacgta cgacgcggcg ggcttgccgg
    11881 tggtgtccgt gggctgggtg ctgggctggt cggagccccg gacctcgtac gcccgggggc
    11941 ggtgcgggtc cctgcggagg aatcccttgc gctcgagggc catgagctgg tgggccaccg
    12001 acgaggtgct cgacaggccg accgcctggc cgatctcgcg catcgacggc gggtaccccc
    12061 gccgctgcac ggagtcgcgg atgacctcga tgacgcgccg ctgccggtcc gtgaggccgg
    12121 agctgtcggc ccggatgccg ggaggtcgac cgggcagcga gcggcctggc ttcggcccct
    12181 ccggggtcgt ggctgcgtca ttcatggcat gcaccgactc gaatcggctc tgtgagcggt
    12241 cctgggcagt gatggtggca ctgtctgcgg tggtggtcac gtcggcccct ctcgaatggt
    12301 ctccctagct ggacaacggt agttgctttc gaaaggttgc gccaaacaca cgttcgagtg
    12361 aaaaattgca gattgcctga cgtgggcatt ctgctgggtg tagtgcgaat gatcgaaccg
    12421 gccggtgcac ccgttacggt agccttcgcc gccggcggtg gcggcgcggg gtcgttccga
    12481 acttgccggc ccgtcccttc cagtctcgca ttccgatcgc tgggaggtgg gaatgccgag
    12541 cctctgtgtc gtccgcgccg agggcctcga gcactccgcg cagtcggccg atacaggccg
    12601 tgtccgaagc ggccccggag cccgcgcgag gcgacacgct tcgtgacctg aaagtacgcc
    12661 aaaccccaga tctagtggtt gaattggctc cgccacccag aagttgtgtc cccggtgctc
    12721 catggccgag ggcatcgcct atgcttgtgg ctgcttcgcg gggccggatc cggcctgcgg
    12781 ggccagtcgg tcgtgctcag aaggaggggt tgggagccat gcactgtccc ttctgcaggc
    12841 atcccgacag tcgcgtcgtc gacagtcgca ccaccgacga cgggacggcg atccgccggc
    12901 gccggcagtg tccggactgc gcccggcgct tcacgacggt cgagaccgcc tcgctcatgg
    12961 tgatcaagcg cagcggagtg accgagccct tcagccgtac caaggtcatc tccggtgtgc
    13021 gcaaggcgtg ccaggggcgg ccggtcaccg aggacgctct tgcccagctc ggccagcggg
    13081 tcgaggaggc ggtgcgtgcc accggcagcg ccgagctgac cacccatgac gtgggtctgg
    13141 ccatactcgg cccgttgcag gaactcgacc tcgtcgccta cctgcgtttc gcgtccgtgt
    13201 acagggcgtt cgactcactc gaagacttcg aggccgccat cgcggagctc cgcgccggcc
    13261 ggcctcctgc tgaggcaggc gggggcggcg gggccgttga agtccccgtg cccgccaccg
    13321 ccgccgactg agcgagagac gctgaacggc tgggcccgac gaaggcccgc cagccggctc
    13381 agggtggcaa aggacctgct tgcggacgct gtgcgtggcg gccggagcaa cagacacaaa
    13441 ccgtgccccg ggaagatctg ggcacttcag ggcgtttttg cccgtatatg ggaggcggca
    13501 tgaccgagac gacgagcggc ccggcacgag ggtcccgagc caagggatcc aaggcgaaca
    13561 agggcctgcg tatcgagcgc gtccacacca cccccggcgt gcacccgtac gacgaggtgg
    13621 tctgggagcg ccgtgacgtc gtcatgacca actggcgtga cggctcggtc aacttcgagc
    13681 agcgtggcgt cgagttcccc gacttctggt cggtgaacgc ggtcaacatc gtcaccagca
    13741 agtacttccg cggggcggtc ggcacccccc agcgagagac cggtctgaag cagctgatcg
    13801 accggatcgt gaagacgtac cgcaaggccg gagaggacca cggctacttc gcctcgcccg
    13861 ccgacgccga gatcttcgag cacgagctcg cgtacgcctt gctgcaccag atcttcagct
    13921 tcaactcgcc ggtgtggttc aacgtcggca cgccccagcc gcagcaggtc tccgcctgct
    13981 tcatcctgtc cgtcgacgac tccatggagt cgatcctcga ctggtacaag gaagagggca
    14041 tgatcttcaa gggcggctcc ggcgccggcc tgaacctctc ccgcatccgc tcctccaagg
    14101 agctgctgtc ctccggcggc aacgcctccg gaccggtctc cttcatgcgc ggcgccgacg
    14161 cctccgctgg aacgatcaag tccggcggtg ccacccgccg cgcggccaag atggtcatcc
    14221 tcgacgtcga ccaccccgac atcgagggct tcatcgagac caaggtgaag gaagaggaga
    14281 agatccgcgc gctgcgtgac gcgggcttcg acatggacct gggcggcgac gacatcacgt
    14341 ccgtccagta ccagaacgcc aacaactcgg tccgggtcaa cgacgagttc atgaaggcag
    14401 tcgaggcggg cggcaagttc ggtctgcgtg cgcggatgac cggtgacgtc atcgaggagg
    14461 tcgaggccaa gtcgctcttc cgcaagatgg ccgaggccgc ttgggcgtgt gccgacccgg
    14521 gcatccagta cgacgacacg atcaaccgct ggcacacctg cccggagtcc ggccgcatca
    14581 acggctcgaa cccgtgcagc gagtacatgc acctggacaa cacctcgtgc aacctggcct
    14641 cgctgaacct gatgaagttc ctgaaggacg acggcaaggg caaccagtcc ttcgacgtcg
    14701 agcgcttctc gaagatcgtc gagctggtca tcacggcgat ggacatctcc atctgcttcg
    14761 ccgacttccc gacccggaag atcggcgaga acacccgagc cttccgccag ctcggcatcg
    14821 gctacgccaa cctcggcgcg ctgctgatgg cgaccggcca cgcgtacgac tccgacggag
    14881 gccgtgccct cgccggcgcg atcacgtccc tgatgaccgg cacctcctac cggcgctccg
    14941 ccgagctggc cgcggtcgtc ggcccgtacg acggatacgc ccgcaacgcc gagccgcaca
    15001 agcgcgtcat gaagcagcac gccgacgcca acgccgtggc cgtccgcatg gacgacctcg
    15061 acacgccggt ctgggccgcc gccacggagg cctggcagga cgtgatccgc ctcggtgaga
    15121 agaacggttt ccgcaattcc caggcctcgg tcatcgcccc gaccggcacc atcggtctcg
    15181 cgatgtcctg cgacaccacc ggcctggagc ccgatctcgc gctggtcaag ttcaagaagc
    15241 tggtcggcgg cggctcgatg cagatcgtca acggcacggt cccgcaggcc ctgcgccgcc
    15301 tcggctacca gccggagcag atcgaggcga tcgtcgccca catcgccgat cacggcaacg
    15361 tgatcgacgc gccgggcctg aaggccgagc actacgaggt cttcgactgc gccatgggcg
    15421 agcgttccat ctccgcgatg gggcacgtcc gcatgatggc ggccatccag ccgtggatct
    15481 ccggcgcact gtccaagacg gtgaacatgc cggagtcggc gaccgtcgaa gaggtcgagg
    15541 agatctactt cgaggcgtgg aagatgggcg tcaaggcgct cgcgatctac cgcgacaact
    15601 gcaaggtcgg ccagcccctc tccgcgaaga agaaggagaa ggccgaggtc gccgggaagg
    15661 ccgaggagac gatccgcgcc gcggtcgaga aggtcgtcga gtaccgcccg gtccgcaagc
    15721 gtctccccaa gggccgcccc ggcatcacca cctcgttcac ggtcggcggc gccgagggct
    15781 acatgaccgc caattcctac ccggacgacg gtctcggcga ggtcttcctg aagatgtcga
    15841 agcagggctc caccctcgcg ggcatgatgg acgccttctc gatcgccgtc tcggtcggcc
    15901 tgcagtacgg cgtgccgctg gagacctacg tctcgaagtt caccaacatg cgcttcgagc
    15961 cggccggtat gacggacgac cccgacgtgc ggatggcgca gtcgatcgtc gactacatct
    16021 tccgccgcct ggcgctggac ttcctgccct tcgagacccg ttccgcgctc ggcatccact
    16081 ccgcggagga gcgccagcgc cacctggaga ccggttccta cgagccgacg gacgacgagc
    16141 tcgacgtgga gggccttgcg cagtcggccc cggtacagca ggagctgaag gccgtcgccg
    16201 cgccgaaggc ggagattccg gcaccgcagc aggcgcacac ctccgccgag ctcgtggaga
    16261 tgcagctggg catcagcgcc gacgctccgc tctgcttctc ctgcgggacc aagatgcagc
    16321 gtgccggttc ctgctacatc tgcgagggct gcggctcgac cagcggctgc agctgaaaat
    16381 gagcgccctt caggcgtgaa gtagaccggt cagagcgggg agtcggcgaa atccggctcc
    16441 ccgctcggcc gctgtgatca ccgaggcttc ctgtcgcccg gttcccccag tgctctggct
    16501 atcaggtcgg tatcgcagta ctcggtcagt gcttgcagtt ttccctcttt gatgtggcaa
    16561 acccagcagt acgtgttgtt gtagggcttc ccttccgtgg ttgtggcgcg gccgctgcac
    16621 tccaccacca cgcaatcgcc ggcggcgatg aaacgttggg gggtgttcgt gtatatgtcc
    16681 gcaaactggg cgagcagggg acggaagagg tcgtcgagga cggcctgttt gccctcgtag
    16741 gtcccggacc atttcgtcgt gccgatgatg gtccagcgga agtcgtcggc gagactctcg
    16801 gcgaggggcc ggccgtcccc cttcatcagc ccggcgaaga tgtgctgcat cagtcgtgtg
    16861 ttctcggtct cggccatgtc tgctccctca tctcgttcgc ctgtatcgag cgcggcacca
    16921 ccggttgaac cggtcagggg ggagagccga tcgggctccc ccgcccttgc gggtctgctc
    16981 gcgttccacg ttctgcgcct gatcagcggg cggggtcgcc catcaccgtg agatatgtct
    17041 gagggtcccc gtcgaaaccc agcagcctgc cgctgaacgt ccagcccccc gcctcgccgc
    17101 ggacgaactc gccgatcgtc gccgccgtgg cgtccgggac agcggtgaag tcgtgccgcc
    17161 cgatctccct gtgtccttcg aggacgcgca cggaggcgtt cacgacgtcg ccgaacaccg
    17221 tgcggccgtc gccctgctga atcactaccc cgacgacgac acggccgtac ctcgccgcca
    17281 gccggtcgaa ttcgagggtc atcacctcgt ccgccccgaa gccctgaccg gtcctgctct
    17341 ctctggccag gatgatcgtg ccgtcgggcg agcggctgtc gaagtgcacg acgtaggcgg
    17401 gttcaccgaa tggggcctcc gcggaatacg tcgcggccac caggtcgaga tcatggggcg
    17461 actcaccgag cgggctgggg tcccacctga gggccacctc tgccttccgg acgcccttgt
    17521 tgaggctgtt cacactcttc cttccccgta actgtcggaa actgtacgtg cgttgacggt
    17581 agccgttccg tgcgggatgc ggcctctgac gcaccacctc gtcgcggaac gcctcgatct
    17641 cactgctgac ctgacggatg agatgggtgt tctcgatccg gtccacgtac gggcagcgcc
    17701 gtgcggtccc cgcgagtggg aagacgaaac agatcgacat cagggcgacg aggatgcgct
    17761 gcgcggactc gaggcggtcg aacagcggtt ggtatgcagg gccgtcatga tgatcgcggc
    17821 gggcggacac ctgttggcga tatgccctgc gccccggggg cgcacctggg tccacgggcg
    17881 ggcgctgtga cgcagagagt gaccccggcc acgtcccggg ccgtacgatg gcgcggtgct
    17941 ggtcaagtgg attcgctgca cggtcgtgga ccgccgaggg ttcgagcgcg ggcagcggaa
    18001 atgggcgggg ctgctgggtg agccgggatt ccgggggcag ggcggagggt ggagcaggat
    18061 acggccgaac gttgcccacg tcttcgcctt ctgggagacc cgggccttct acgactcgtt
    18121 catggcgcgc tcccacgacc ggctcgcgtc cgggcaggcg ggcacgtaca aggactccca
    18181 ggccaagttg ttcgatcacc gcttcgacgt caagacgggc ttcgaaccgc ggttcaccga
    18241 atccgacgtg gtcagggtgg cgcactgccg ggtccgcgag gacagggtcg aacacttctc
    18301 cttgatgcag gagaaggtgt ggaatccggc catggcgggg tcgcccggga tggtgcgggg
    18361 cgtgttcggg gaagcgcccg gcaacgagtt cctcgtgatg tccatgtggc tgtcggcggc
    18421 cgagcacggg aagtaccgcg ccgaacgcgt cgagcgactg ctgttgcggg cccagacggc
    18481 ggcggacgtg gcggcactgg ccggggacgt cgtcgccctg gaaccgtcct ggacggtatg
    18541 acgggccgcc cgcagcggcc gtcccgggca ggccataggg tcgaggtatg gcgcgaccgc
    18601 gacgtatcgt cctcgtccgg cacggggagt cggtgggcaa tgccgacgac acggtgtacg
    18661 aacgcgagcc cgaccatgcc ctcccgctga ccgccgccgg cctggcccag gccgccgaga
    18721 ccggagcacg gctgcgggag ctcttcggcc gcgaacgggt cagcgtctac gtctccccgt
    18781 accgccgcac ccttgagacg ttccgggcgt tcggactgga ccccgggctg gtgcggatca
    18841 gggaggagcc gaggctgcgg gagcaggact gggggaactg gcaggaccgg gaggacgtac
    18901 ggctgcagaa ggcgtaccgc gacgcgtacg gccacttctt ctaccgcttc gcccagggcg
    18961 agtccggtgc cgacgtgtac gaccgggtcg gcgcgttcct ggagagcctg caccggagct
    19021 tcgtggcacc ggatcatccg ccgaacgtac tcctggtcac ccatggtctg accatgcggc
    19081 tgttctgcat gcgctggttc cactggtcgg tcgcggagtt cgagtcactc tccaatccgg
    19141 ccaacggcga gacccgcacg ctgcagctcg gagaggacgg gcgataccac ctcgaccggc
    19201 ccttcgagcg ctggaggacc ccggagccgt acggagccac cggttagagt ggcaggaaga
    19261 tgaccgctga ttccgcatcc gacccgcgct tcgtacgcgc cctggacagc ctgcgaggcc
    19321 tgtccgtggg agacgccctg ggctcccagt tcttcgttcc ctccaactac cccctgctga
    19381 agcggcgcga gctgccgccg tccgtctggc agtggaccga cgacaccgag atggcctgct
    19441 ccgtcctggc cgtcctcgtc gagcaccacc gcgtggacca ggacgccctc gcccggtcct
    19501 tcgccgagca tcacgacttc gaccgcggct acggccccgc ggtcaaccgg ctgctccggc
    19561 tgatcaggca ggggggcgac tggcgggagc tgtcggcgga gctgttcaag ggccaggggt
    19621 cgtggggcaa cggctcctcc atgcggatcg cacccctcgg cgcctggtac gcggacgacc
    19681 cggagcaggc gacgcaccag gccgagatct cctcgtaccc cacccaccag caccgggagg
    19741 ccgtggtcgg cgccatggcc gtggccgcgg cggccgccct ggcggcgaac ccggcgggac
    19801 cgcccggacc tgcggagctg ctggacggtg tcatcgccct ggtccctcgc agcgcggtgg
    19861 gcgccggtct gcgccgggcc gtggacatgc tcgactacaa cgaccccggg accgtcgccg
    19921 ccgtactggg cagcgggcgg cgtaccagtg cccatgacac cgtgccgttc gcgttgtggt
    19981 ccgccgcgcg gtcgctcggc gacttcgagc aggcgttctg gacgaccgcc caggtgggcg
    20041 gtgacgtcga cacgacatgt gccatcgcct gcggagtcgt cgccgcgagc aaggcgggac
    20101 agccgcctgc ccactggctg gagcggaccg agcagctgcc cgactggctg cccggggcgg
    20161 accgggccgg ctgacgcgag cggcatcgga cggtgccgga tcagcggcgg acgcaacctg
    20221 gggcggccgg gtacaggccg tcccccatga ccacggcctg tacccggcgc gtcatgcggc
    20281 gtggccgccg ggccccgccg ccccgctgag tgcctccagg tcgctcttgc ggacccgtat
    20341 cacgaagagc gccgccacca cggcgagcgc gaccaggccc accccggccc agagcgcggt
    20401 ggcgatgcct tcggcgagca cctggtggcc ccacggaggc ggcagctcgt gggacctggc
    20461 gaaggcctcc tgctgcgcgg gcgtcgcctc ggcgaggaag gacggcaact gccgctcggc
    20521 ctcgtcgcgg cttgccgtcc cgaacacggt catcaggatc gacagaccga gggaaccgcc
    20581 gaccatctgc gtggcattga gcagactcga cgcggcaccc gactcgtgct gcgccacacc
    20641 cgacacggcc gtcagcgtcg ccgtcacgaa caccaggccc atgccgaagc cgaagagcag
    20701 catcggccag agcaccgcgg ccacgtagga gctgtcgggg gatatgaagg tcagccacgc
    20761 catgccgctc cccgtgaaca gcgccccggc ggtgaggaac ggcttgggcc ccagcaccgg
    20821 cagcagcttc gaggagaggc ccgccgcgat cacgatcatc acggtgacgg gaagaaacgc
    20881 gaggccggag gtgatggggc tgtaatccag cacgttctgc acgaacagga cgatgaagaa
    20941 gaacatgccg aacatcgcgg ctgcgaggct catcatgatc agatacgtgc cggacctgtt
    21001 gcggtcggcg aacatgcgca gcggcgtgat cggatcgcgt gccttgcgct cggtcagtac
    21061 gaaggccgtc agcaggacca ccgcagcggc gaacgcgccg agcgtgagct cgtcgctcca
    21121 gccgtcctcc gaggctcgga tgaagccgta gaccagtgag gccatgccca cggtcgaggt
    21181 gagcgcgccc gccacgtcga accggccggg gtggcgctcg gactcgttga tgaaaaccgg
    21241 cgcgagagcg gcgatcagga tgccgatggg cagattcacg tagaagaccc agcgccagtc
    21301 cagccactcc gtgagcatgc cgccggccag cagcccgatg gccgcgccgc ttgcggagac
    21361 ggccgcgaag atgccgaagg cgcggttgcg ctcaggccct tcgcggaagg tcgtggtgat
    21421 cagcgcgagt gccgtgggcg aggcgatggc tccgcccacg ccctgcagtg cgcgggccgc
    21481 gagcatctgc cacggttcct gcgcgatccc gcacagcagc gacgcgaagg tgaagagcag
    21541 cacaccggag acgaacaccc ggcggcgccc gaggatgtcg cccgccctgc cgccgagcag
    21601 caggagcccg ccgaaggtga gggtgtaggc gttcaccacc cacgagagtt gggtggtggt
    21661 gaactccagt gccccctgga tgtgcgggag tgcgatattc acaatcgtgg tgtcaagtac
    21721 caccatgagc tgcagagcgg cgatgacggc gagcgcgata ccgggccgcc cctgtcggcg
    21781 ggccgccccc ggtggaacgg gtgctcttag ctgagaggtt gtcaccatgg gtcccccaca
    21841 tatgagttag tgaacgaagg cgttcacttt tccgtaaacc gtagagagtc cccgtcagtg
    21901 aacgcaagcg ttcactggac ctcccgtccc caacggagat atgaagatgg ccacttcgcg
    21961 ccggaccggt gccacagagg ctccgtcggc cccgctgcgc cggagagggc ccgtgctgga
    22021 gcgggcgatc ctcgaagccg ccctggaact gctcggcacg gtcggctgga gcgggttcac
    22081 gatggaaggg gtcgccgccg gggcgcagac cgggaaggcg gccgtctatc ggcgctggcc
    22141 ctcgaaggag gacctcgtcg ccgacgccct cgaggccggg ctcccgcccc tggaccagga
    22201 cgccgatcag gggggcgtcc gggaggacct cttccatgtc tgccggcggg tgcgggacgc
    22261 gatgttctcc cgtaccgggg tcgcgctgcg atcagtcctt cacgagtgcg atgccgtcgc
    22321 ggccgaacgc ttccagggcc tgatcgtcaa tcgggttgtc gagccgtcca aggagctctt
    22381 ccgtgcagtg gtgcggcgtg gtgtgagccg tggtgacgtc cggccggacg cggcctgcga
    22441 actggtcctc gatgtgatcc ccggcctgct gatgtaccgc tcgaaggtgt gcggaagcga
    22501 atggccggac acggacatcg cccagatgat cgaccaggtc atggtcccgc tgctccgccc
    22561 gcacagctgc cggccgatcg acggcggatc gtgacccgta tccggttgcc atcgggccat
    22621 ccccgcggcg tacccttgct ggcgccatgc cgtacgaacc acccacccac gcagtcgagc
    22681 gctcgatccg ggccaccaca ggggccaaga tcgtcgcagg catcgacgaa gtcgggcgcg
    22741 gagcgtgggc ggggccggtg acggtgtgcg cggcgatcac cggactgcgc aggccgcccg
    22801 acggtctgac cgactccaag ctgatcactc ccaagcgccg cgaggggctg gcggtgttgc
    22861 tggagggctg ggtcacggcc cacgccctcg gtcacgcctc tccggaggag atcgacgaac
    22921 tggggatgac ggcggccctc agactggccg ccggccgggc cctggaggga ctgccggtcc
    22981 gccccgatgc catcatcctc gatggcaagc acgactacct cggagtgccc tggcaggtgc
    23041 gtacggtgat caagggggac cagtcctgcg tggccgtggc cgccgcatcg gtgatcgcca
    23101 aggtgcgccg ggacgcgatg atggcgcaac taccggagga cttcgccgtt ttcggcttcg
    23161 ccgagaacgc cggctacccc tcgcccgtgc acaaggccgc cctccgggag ctgggaccca
    23221 ccccgtacca ccggctctcc tgggcctatc tcgacgccct gccccggtgg cggcatctca
    23281 agaaggtccg tatctccccg gaggcggccg aac
//
