LOCUS       NZ_BMWB01000006        10219 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence06, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000006
VERSION     NZ_BMWB01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 280952)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 241510
            Orig. end                         :: 251729
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10219
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10219
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10219
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5219](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5219)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    511..524
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.58"
                     /tool="antismash"
     gene            complement(1732..4044)
                     /locus_tag="IE198_RS13140"
                     /old_locus_tag="GCM10010381_26610"
     CDS             complement(1732..4044)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320917.1"
                     /locus_tag="IE198_RS13140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26610"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_189885989.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.4e-38, bitscore:
                     123.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTNHNAPVSGRQLPPAAGRGRHRPEAAAPGGRRGSRRAAPPPR
                     RRQQRRAGRPGTVRTPTVLQMEAVECGAAALAMVLSHYGRHVPLEELRIACGVSRDGSR
                     ASNVLKAARSYGLAAKGMQMEATALAEVQPPAILFWEFNHYVVYDGTGRRFGRRGVHIN
                     DPDKGRRFVAAEDFDTSFTGVALVFEPDRNFRKGGRKPGIMSAVPARLRGTTGTLFAAF
                     LASLLLVAVGAAVPALSRTYIDMFLIGGRTSLLGTLFAAMAVMVALTAVLTGLQQANLL
                     RGRIISSTLSSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLAAAAVDG
                     VVVILYAALLWSYDPQLTVLGVLIALLNVVAMRIVIRLRSTHTQKLRADSARLTNTSYT
                     GLQLIETMKATGGENGFFRRWAGQHATTLDVQQRLGVPSAVLAVVAPTLATLNSALILW
                     IGGLRAVEGHISIGLLVAFQALVARFTAPITRLNGVAGRIQDFAADMARLKDVESFPVD
                     PLYSRDEPDPSSRRLKGHVTLENITFGYSPLDAPLLSGFSLSVGPGRQVALVGGSGSGK
                     STVSRLISGLYRPWEGTIRIDGRLLEDIPRGALAASVSFVDQDIFLFEGTVRDNVTLWD
                     PSIPDEAVEAALRDAAVHDVVMRRPDGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSI
                     LVLDEVTSALDAETERIIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGAVVERGRH
                     EELVAAQGAYAELVKEH"
     gene            complement(4041..4847)
                     /locus_tag="IE198_RS13145"
                     /old_locus_tag="GCM10010381_26620"
     CDS             complement(4041..4847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="IE198_RS13145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26620"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_189885990.1"
                     /transl_table=11
                     /translation="MQFRKQALSKLQSPEEIDLPVRFARPQGQLVLIVTVVVMIAAGGW
                     AMTGTVSSTLDAPGILTHAQGSYVLQSPVAGQVTEVLAEEGELVRADAPLLKVRTAQGG
                     TVVRTVAAGRVTALVATIGSVVTPGSDVAAVERIEEADDPLMAVVYVPAERGSSVPVGA
                     KVDLSVQSVATEQYGVLRGRVTSVGRTAQTRQRIAAFLGSSQLGEQFSQAGQPVAVLVE
                     LERTQSTESGYRWSSSEGPPYPLESMTLTGGAVHLAEQRPIDWLLP"
     gene            complement(5001..5219)
                     /locus_tag="IE198_RS13150"
                     /old_locus_tag="GCM10010381_26630"
     CDS             complement(5001..5219)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_l"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018849411.1"
                     /locus_tag="IE198_RS13150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26630"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_189885992.1"
                     /sec_met_domain="strepbact (E-value: 1.1e-20, bitscore:
                     68.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_l (E-value: 4.4e-06, bitscore:
                     21.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFVPTQEISDSELDNVAGGLHSQTVDNVVAAANIIAPVSETVAT
                     ASGVVAGATGINAASIGGPVSGVVAGL"
     misc_feature    5378..5395
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            complement(5720..6667)
                     /gene="opcA"
                     /locus_tag="IE198_RS13155"
                     /old_locus_tag="GCM10010381_26640"
     CDS             complement(5720..6667)
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /GO_process="GO:0065003 - protein-containing complex
                     assembly [Evidence IEA]"
                     /codon_start=1
                     /gene="opcA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320914.1"
                     /locus_tag="IE198_RS13155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26640"
                     /product="glucose-6-phosphate dehydrogenase assembly
                     protein OpcA"
                     /protein_id="WP_189885994.1"
                     /transl_table=11
                     /translation="MKTDLTDTTASKINKALVRGRRAIGTPAVGMVLTLVIVTDEENAY
                     DAIKAAGDASREHPSRTLVVIKRHARSPRERHETRLDAEVRIGSDAGAGETVLLRLHGE
                     LTHRADSVVLPLLLPDAPVVVWWPVDAPPVPAKDPLGALAQRRITDAYAVERPIEELDA
                     RAAGYEPGDTDLAWTRLTPWRSMLAAALDQARSEVVSAVVESEADNPSAELLARWFSDR
                     LQVPVEQVVTDGPVVTAVRLHTVDGEIHIDRPEGPVARLSIPGQPTRVLALKVRSTAEL
                     IAEELRRLDPDEAYAAALRAEITAPAQRAAADTA"
     gene            complement(6664..8247)
                     /gene="zwf"
                     /locus_tag="IE198_RS13160"
                     /old_locus_tag="GCM10010381_26650"
     CDS             complement(6664..8247)
                     /EC_number="1.1.1.49"
                     /GO_function="GO:0004345 - glucose-6-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="zwf"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320913.1"
                     /locus_tag="IE198_RS13160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26650"
                     /product="glucose-6-phosphate dehydrogenase"
                     /protein_id="WP_229833888.1"
                     /transl_table=11
                     /translation="MSENRSQSRSQQRTRQRSLGSGWANPLRDPLDRRLPRIAGPSGLV
                     IFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARREWQDQDFAAEVHQAVRDHART
                     PFREEVWRQLSQGMRFVQGDFGDDAAFEQLKATVEDLDKAQGTGGNFAFYLSVPPKFFP
                     EVVQQLKDHSLSNAPKGSWRRAVIEKPFGHDLESARDLNEIVHEVFAPDEVFRIDHYLG
                     KETVQNILALRFANTLFEPIWNRSYVDHVQITMAEDIGIGGRAGYYDGIGAARDVIQNH
                     LLQLLALTAMEEPASFDAASLVTEKLKVFKAVKVPADLAGHTVRAQYAADWQGGEKVLG
                     YLQEEGIAPDSRTDTYAAIKLEIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSP
                     FDSTATAELGENALVIRVQPDEGVTVRFGSKVPGTSMELRDVTMDFAYGESFTESSPEA
                     YERLILDVLLGDANLFPRTEEVEESWRILDPVEEFWDRSGRPAQYPAGTWGPAEADEML
                     ARDGRSWRRP"
     misc_feature    complement(8347..8364)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(8459..8474)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(8476..9438)
                     /locus_tag="IE198_RS13165"
                     /old_locus_tag="GCM10010381_26660"
     CDS             complement(8476..9438)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884624.1"
                     /locus_tag="IE198_RS13165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_26660"
                     /product="TerC family protein"
                     /protein_id="WP_189885996.1"
                     /transl_table=11
                     /translation="MHDVPYWLWVVFAAAVLVSLAVDLLAHRQAHVIGFREAAAWSGVW
                     VGLALVFGAVVFLVVGTQAGVEYTTAWLLEKSLSVDNLFVFALIFGYFKVPRAYQHRVL
                     FLGVLGALVFRGVFLVAGVAVVSRFTAVLYLFAAILFYSTYKILKEEEDSFDPGRSIAV
                     RLLRRVMPVRNSYADAKFFLKEAGRYVATPLLAVVAAIEAADLVFAVDSVPAVLAVSND
                     AFIVYTSNAFAILGLRALYFMLAGLLDRFHYLSKGLALILSFIGVKLILQASHEVISTA
                     VPEIPSPISLAVIVVVLTVSVALSVLRPEAGDRAPEKDG"
ORIGIN
        1 agttccacca gcctgcgctg ccagcggacc tgccagagcc ccatgccgag gaacaccgcg
       61 ccgatgacga gcagcatgcc gatggcggcg agagccagcg gcacgctgta ccagagcagc
      121 agcccgacgt tcatcgcacc gacggtggtg gactgcaggg ccaccgggcc gatgccggac
      181 aggacgcggc ggatcgagga gatgcccatg gccgcgctgg ccagttcccc ggtcgaccgc
      241 tcggcgaaga acctggtcgg cagcctcagc agccggtccc agacagcggg ttgaagggtg
      301 ctctcgatac gtccctccat ccgcaggatg gtcaggttct gcaagagcat gaacgcggcg
      361 gtgacgatgc cggtgatcat gacggcgagc gagagctgca cgatcaggtc cgtctgcgcc
      421 ttgggcacgt acacgccgag gacctgtccg gtggcgatgg gcacgagcgc gccgagggcg
      481 acggtgacga ggccgccgag cagcaggttc cgcacgtcca tgcgggtgcc gcggaggctg
      541 aagcgcacca gcccccggac gctcgcgggc cgctcgggca gcggccggta gaacatgacg
      601 gcgcgttccc cgaactcgcc ggcgttctcc ttgccgatcc gggtccggga gcgggtgaga
      661 gggttgaccg cctcgtagcg tccacggcgc cagatcagtg cgacgggtgc tccggaggcg
      721 gcccggtggc cgacgagcgg accggcgtcg gtgcgccacc agtggccctg gaggcggacc
      781 ggacgggtgc ggacacggga ggcgacggcg atgcgttcga cggggcccac gcggtcctcc
      841 gcgggcccgc ctttcggcgg gtcggccagg gtgaccccgg cggcgcgggc gacgtggcgg
      901 cacaccgcga ggagcgtgtc gtcgccgtcc gctcccccgt ggccgcgcga ggcccggtcc
      961 ggtctgccga tggaggcgag cagcgcctcg tcggcgcggg ctccggcgtc ggcgccggcc
     1021 ttgataccgg cggcggtccg gtcctcgtgg gcccgttcca gctcctcgat ccagccgtcc
     1081 accgcggaca gcaaccggta ctgctggttc accatgcgct gccacatggc gccctcgacg
     1141 agcaggtcgc ccgccgcctc ggcgctgtag gtggcgccgt actgaacact gcccggctcg
     1201 acctgcatcc acaggacgtc gtcgtcggcc atggtctcgg cggccgagtg gccctcgagc
     1261 ggcgcctcga acagcacccc gaggccgcga ccgacaccca gtccgaaggc gtactccagt
     1321 tgggaggtgg ccgtgcggcc gtacgggtcc tgatacgcgg acggatacgg ctcggcgtac
     1381 tccgcgtact ccggcacgta cagctcccgc agcgggatcc ggcgcagcac gcagtcctgc
     1441 gagggccggc cggtcagtgt gtgccggggg ccctcgaccg ggccgaggag cagggtgccc
     1501 gggtcgaggc ggccgaggaa gtgccagtgg ccctgctcgg ccgcgtccac ggcgaacagg
     1561 tccagcgtcc cgcccacgac gagccacagc accagcggcc cttccagatg cagactgcgc
     1621 agaccggtgc agtcgacggg cgttcccatg ccgccgagcg cgtggatcac cgggtcggtc
     1681 tgcgcgaagg caggctggtg gccggtggcc ggggggtgaa cggacgacac gtcagtgctc
     1741 cttgaccagc tcggcgtacg ccccctgcgc ggcgaccagt tcctcgtggc ggccgcgttc
     1801 gacgacggcg ccatggtcga ggaccacgat ctcgtcgctg tcgcgcacgg tgctcagccg
     1861 gtgggcgatg acgacgcatg cgcagccgcg ccgacggagg ttgtcgatga tgatccgctc
     1921 ggtctccgcg tcaagggcgc tggtgacctc gtcgagcacc aggatgctcg gccggcgcac
     1981 cagcgcccgg gcgatctcga ggcgctggcg ctgcccgccc gagaagttgc ggccgtcctg
     2041 ttcgacgcgg ctgtggatgc cgtcggggcg tcgcatcacg acgtcgtgga cggccgcgtc
     2101 ccgcagggcg gcctcgaccg cctcgtccgg gatggagggg tcccacaggg tcacgttgtc
     2161 gcggacggtg ccctcgaaga ggaagatgtc ctggtcgacg aaggagacgg acgcggcgag
     2221 cgcgccgcgg gggatgtcct cgaggagccg gccgtcgatg cggatggtcc cctcccaggg
     2281 gcggtagagg cccgatatca gccgggagac ggtcgacttg ccgctgccgg agccgccgac
     2341 aagggccacc tgccggccgg gcccgacgct gagggagaaa ccgctcagca gcggcgcgtc
     2401 gagcgggctg tagccgaagg tgatgttctc gagcgtcaca tggcccttga gccgacggct
     2461 gctcgggtcg ggctcgtcgc gggagtagag ggggtcgacc gggaagctct ccacgtcctt
     2521 gaggcgggcc atgtccgcgg cgaaatcctg gatccggccc gcgactccgt tcagccgggt
     2581 gatcggggcg gtgaagcggg ccacgagcgc ctggaaggcg acaaggagac cgatcgatat
     2641 atggccttcg acggcccgca gtccgccgat ccagaggatg agggcgctgt tgagcgtggc
     2701 gagggtgggc gcgacgacgg ccaggaccgc gctgggcacg ccgaggcgct gctggacgtc
     2761 cagggtggtg gcgtgctggc ccgcccagcg gcggaagaag ccgttctctc cgccggtcgc
     2821 cttcatggtc tcgatcaact ggaggccggt gtacgaggtg ttggtgaggc gggcgctgtc
     2881 ggcgcgcagc ttctgggtgt gtgtggagcg cagccggatg acgatgcgca tcgcgacgac
     2941 gttgagcagc gcgatgagca cgccgagcac ggtgagctgg gggtcgtagc tccacagcag
     3001 cgcggcgtag aggatcacca cgacgccgtc gacggcggcc gccgccaggt cgcgggcgag
     3061 ggtctcggcc acggcgtcgt tggactgcag ccgctgcacc aggtcggccg ggctgcgctg
     3121 cgcgaagaac gtgacgggca gccgcaacag atggcgaagg aacctggcgc tgctcagggt
     3181 cgaggagatg atccgcccgc gcagcaggtt cgcctgttgc agcccggtga gcacggcggt
     3241 cagcgccacc atcacggcca tggcggcgaa cagcgtcccg agcagcgacg ttcggccgcc
     3301 gatcaggaac atgtcgatgt aggtacggct gagcgccggg accgccgcgc cgaccgcgac
     3361 gaggagcaga ctggccagga aggcggcgaa cagggtgccg gtggttccgc ggagccgggc
     3421 cgggacggcc gacatgatgc ccggcttccg gccgcccttg cggaagttgc ggtcgggttc
     3481 gaagaccagg gcgacaccgg tgaagctggt gtcgaagtcc tccgcggcta cgaaccggcg
     3541 ccccttgtcc gggtcgttga tgtggacgcc gcgccggccg aaccggcgtc ccgtgccgtc
     3601 gtagacgacg tagtggttga actcccagaa caggatggcg ggcggctgca cctcggcgag
     3661 ggcggtcgcc tccatctgca tgcccttggc ggcgaggccg taactgcggg ccgctttgag
     3721 cacgttgctg gcgcgtgaac cgtcccggga gacgccgcag gcgatccgga gctcctcgag
     3781 cggcacatgg cgcccgtagt gggagaggac catggcgaga gcggcggcac cgcactccac
     3841 ggcctccatc tgcagcacag tgggcgtgcg gacggtgccc ggcctgccgg cgcgccgctg
     3901 ctgcctgcgc cggggcggcg gagcggcgcg gcgcgacccg cgccgtccgc ccggcgccgc
     3961 cgcctccggc cggtgcctgc cgcggccggc tgccggcggc aactgccttc cggatacagg
     4021 ggcgttgtgg ttcgtctgtg tcacggcagc agccaatcga tcgggcgctg ctctgcaagg
     4081 tggacggcac cgccggtcag ggtcatggat tcgagcgggt acggcggccc ttcggaggac
     4141 gaccaccggt agccggactc ggtgctctgc gtacgctcca gctcgaccag aacggcaacg
     4201 ggctgaccgg cttgcgagaa ctgctcgccc agctggctgc tgccgaggaa ggcggcgatc
     4261 cgctgccggg tctgcgccgt cctgcccacg gacgtgacgc ggccgcgcag gactccgtac
     4321 tgctcggtcg ccacggactg gacgctgagg tcgaccttcg cgccgacggg taccgacgaa
     4381 ccgcgctcgg cgggcacgta caccacggcc atcagcgggt cgtccgcctc ctcgatccgt
     4441 tcgaccgccg cgacgtccga gccgggggtg acgacggacc cgatcgtggc gacgagcgcg
     4501 gtcacccggc cggcggcgac ggtacggacg acggtcccgc cctgtgcggt gcggaccttc
     4561 aacaggggcg cgtcggcgcg gaccagttcg ccctcctccg cgaggacctc ggtgacctgg
     4621 ccggcgaccg gactctgcag tacgtaactg ccctgcgcgt gggtgaggat gccgggtgcg
     4681 tccagcgtgg aggacacggt gcccgtcatg gcccacccgc ccgcggcgat catcacgacc
     4741 acggtgacga tcagcacgag ctggccctgc ggacgggcga aacgcaccgg aaggtcgatt
     4801 tcttccggcg attgcagctt ggaaagggcc tgcttacgga actgcacgtt gctcttccct
     4861 caactgccga ggactacggg gagttcggcg cgcggcatga ccggtcaacc gcgcgcggcc
     4921 gcgcgccccg gaacctggca ggctccgggg cacacggctc ggcgatgccg gcagagcggg
     4981 gtgccggcga gccgtaggac ttacagaccc gcgacgacac cggagaccgg gccgccgatg
     5041 ctggccgcgt tgatgccagt ggcacccgcg acgacaccgg aggcggtagc gacggtctcg
     5101 gagaccgggg cgatgatgtt cgcagcggcc acgacgttgt ccacggtctg gctgtggagg
     5161 ccgccggcca cgttgtcgag ctcggagtcg gagatctcct gggtggggac gaagctcatg
     5221 aaagttccct tcggatggat actgcgaatt gctgcgaccg gccacgcgaa aggagtgggc
     5281 cggccgcccg gcgggcgtgg ggggattccc ggaccaggaa cccttcttcg aatcccgcgg
     5341 tgcgaaggat caaagcatgt gaggcacttg ggcggccaat cccggacagc ggatccacgc
     5401 ggagagcggc acccaattgc ccccacgtgg acggccctgc atcaattgac gccaccttct
     5461 tcaccggacc gtcaaactcg cgcgcacaga agacacgcgg ccgcttcacg gcgaagtgga
     5521 cattcccgca cagaggcaga tgccggcagg tcaggacgga agacagcgag ggcagaccgt
     5581 gtgccgcatg agtattgagt gtgcagattc acgggaggtc gaggtttctt gacggcacct
     5641 cacaaagcct tcacaccggg gtggagcgac aatgcactcc accccgggac gagtaatcac
     5701 gcaagtgcgg agcgttacct caggcggtgt ccgcggccgc tctctgcgca ggtgcggtga
     5761 tctcggcgcg aagtgccgcg gcgtatgcct cgtccgggtc gagccggcgc agttcctcgg
     5821 cgatcagttc ggccgtactg cgcactttca gcgcgaggac ccgggtgggc tgcccgggga
     5881 tgctgagccg ggccaccggc ccttccggcc ggtcgatgtg gatctcgccg tccaccgtgt
     5941 ggagccggac ggcggtgacg accggcccgt cggtgacgac ctgttcgacc ggcacctgca
     6001 gccggtcgga gaaccagcgg gcgagcagtt cggcgctggg gttgtcggcc tcgctctcga
     6061 ccacggcgga gacgacctcc gaacgggcct ggtcgagcgc cgcggcgagc atggagcgcc
     6121 acggcgtgag tctggtccag gcgaggtcgg tgtcacccgg ctcgtacccg gcggcgcggg
     6181 cgtcgagctc ctcgatcggc cgctccaccg cgtacgcgtc ggtgatgcgc cgctgggcga
     6241 gcgcccccag cgggtccttg gcgggcacgg gcggtgcgtc caccggccac cagacgacga
     6301 cgggggcgtc gggcagcagc agcggaagca ccaccgagtc ggcgcggtgg gtgagttcac
     6361 cgtggagccg cagcagcacg gtctcgccgg ctccggcgtc gctgccgatg cgtacctcgg
     6421 cgtcgaggcg ggtttcgtgg cgctcccgcg gcgagcgggc atggcgcttg atgacgacca
     6481 gggtgcggga ggggtgttca cgggaggcgt ctcccgctgc cttgatcgcg tcgtaggcgt
     6541 tctcctcgtc ggtgacgatg accagggtga gcaccatgcc gacggccggg gtgccgatcg
     6601 cacgacgtcc cctgacgagc gccttgttga tcttgctggc cgtggtgtcg gtgaggtcgg
     6661 tcttcatggc cttcgccagc tccgtccgtc tcgtgcgagc atttcgtccg cttcggcggg
     6721 cccccaggtg ccggccgggt actgcgccgg cctgccgctg cggtcccaga actcctcgac
     6781 ggggtcgagg atccgccagg actcctccac ctcctcggtc cgcgggaaga gattggcatc
     6841 ccccagcagc acgtcgagga tgaggcgttc gtacgcctcg gggctggact ccgtgaacga
     6901 ctccccgtag gcgaagtcca tcgtcacgtc gcgcagctcc atcgatgtac ccggcacctt
     6961 ggagccgaac cgcacggtca cgccttcgtc cggctggacg cggatgacca gcgcgttctc
     7021 gccgagttcc gccgtggcgg tggagtcgaa cggcgagtgc ggggcgcgct ggaagacgac
     7081 cgcgatctcg gtgacgcggc ggcccagccg cttgccggtc cgcagataga aggggacccc
     7141 cgcccagcgg cggttgtcga tctccagctt gatcgcggcg taggtgtcgg tccgggagtc
     7201 gggggcgatg ccctcctcct ggagataccc gaggaccttc tcgcccccct gccagtcggc
     7261 cgcgtactgc gcccgcacgg tgtgtccggc caagtccgcc gggaccttga cggccttgaa
     7321 gaccttgagc ttctcggtga cgagggaggc ggcgtcgaag gaggccggct cttccatcgc
     7381 ggtcagcgcc agcagctgga ggaggtggtt ctggatcacg tcacgggcgg cgccgatgcc
     7441 gtcgtagtag ccggcgcggc cgccgatgcc gatgtcctcg gccatcgtga tctgcacatg
     7501 gtcgacgtac gaccggttcc agatcggttc gaagagcgtg ttggcgaacc gcagcgccag
     7561 gatgttctgg acggtctcct tgcccagata gtggtcgata cggaagacct cgtccggcgc
     7621 gaacacctcg tgcacgatct cgttgaggtc gcgggcgctc tccaggtcat ggccgaacgg
     7681 cttctcgatg accgcccggc gccaggaccc cttgggcgcg tttgacagtg agtggtcctt
     7741 cagttgctgg acgacctcag ggaagaactt cggtggtacg gagaggtaga aggcgaaatt
     7801 gccaccggtg ccctgagcct tgtcgaggtc ctcgacggtg gccttcagct gctcgaacgc
     7861 ggcgtcgtcg ccgaagtcgc cctggacgaa acgcattccc tgtgagagct gacgccagac
     7921 ctcctcacgg aacggggtgc gggcatggtc cctgacggcc tggtggacct ccgccgcgaa
     7981 gtcctggtcc tgccattccc ggcgggcgaa gccgacgagc gagaagcccg gcggcagcag
     8041 cccccggttg gccaggtcgt acacggcggg catcagtttc ttgcgcgaca ggtcaccggt
     8101 gacgccgaag atcaccagcc cggagggacc ggcgatacgg ggcagccgcc ggtcgagcgg
     8161 gtccctcagc ggattcgccc agccgctgcc gagcgaccgc tgtcgcgtcc tctgctgcga
     8221 cctgctctgc gaccggttct ctgacatgcg gtcaggcctc cctgcgccga cggcgtgcgg
     8281 atgcgtcctt tccgaggatc gcatctcccg ctgatcctgc cggggctcac acacccgtcg
     8341 gtgcgagttc cgcgcaaggg gattgatcgc tgttttgcgg gcacacccgc cggccccggg
     8401 ccgcgctccc gctttgcgcc cgctgtgcat gcctttgaac tcgacctggg gtgcttcagt
     8461 gacactggtg tgacgtcagc cgtccttctc gggcgcccgg tctccggcct cgggccgcag
     8521 cacgctgagc gcgacggaca ccgtgagaac gacgacgatg acagccaggc tgatgggcga
     8581 gggaatctcg gggacggccg tgctgatcac ctcgtgggag gcctgcagga tcagcttgac
     8641 gccgatgaac gacaggatca gcgcgagacc cttgctcagg tagtggaagc ggtccagcag
     8701 gccggccagc atgaagtaga gcgccctcag tccgaggatg gcgaacgcgt tgctcgtgta
     8761 gacgatgaag gcgtcgttgc tgaccgccag gacggccggc acgctgtcga ccgcgaagac
     8821 caggtcggcc gcctcgatcg cggccacgac ggccagcagc ggcgtggcga cgtaccggcc
     8881 ggcctccttg aggaagaatt tcgcgtcggc gtacgagttc cgcaccggca tgaccctgcg
     8941 cagcagacgt acggcgatgc tcctgccggg atcgaagctg tcctcctcct ctttgaggat
     9001 cttgtaggtg ctgtagaaga ggatcgcggc gaagaggtac aggactgcgg tgaagcggct
     9061 gacgacggcc actccggcaa caaggaagac gcctcggaag accagggccc ccagcacgcc
     9121 gaggaagagc acacggtgct ggtaggcgcg gggcaccttg aagtacccga agatcagcgc
     9181 gaacacgaag aggttgtcca ccgacagact cttctccagc agccaggcgg tggtgtactc
     9241 gaccccggcc tgcgtgccga cgacgaggaa gacgacagca ccgaagacca gcgccagacc
     9301 gacccacaca ccgctccatg ccgccgcctc ccggaagccg atgacatgcg cctgccggtg
     9361 agcaagcaga tcgaccgcca gcgaaacaag caccgcggcg gcaaagacga cccacagcca
     9421 gtacggcacg tcgtgcacga ggcagtcctc acaaggcgac cggcataacc gggcagcgcc
     9481 cctctctcct acgagtctgg acgagcgggc agccgttgtc ctccgcgcgg tgcgggaggg
     9541 tcagcgggcc gtgagcagga tccacacctg gccgggggcg aagttcagcc gctcccccgc
     9601 cgcgtcggtg aagacggtgt ccccctccgc ggtcgcccgc tgccaccggg cgtcgtagcc
     9661 gcggccgtcg cgcagcacca gcgccgtacc cgagccgacc gtctcggtgt acggggacac
     9721 gctgcccgac cggtcgcgga actgcgaagg gcggacctcg gtgtgctgca cgaccaccgt
     9781 cgcgggtgcg agcggaccgc cgtccgtggt ccgcgcggcg gccccgtcca tcgccaccag
     9841 ccagcgtttc cgctcgggcg accagctgaa ggtgtaccgg gcggagggat agcgcaccgt
     9901 gtgctcgtcg agtgggcggc cgccgtcggg ggcggtgccg aagcgcatgc cgatgtccga
     9961 ggcgtcgctc acgtcgcggg cggcggcgag agcacgttcg ggtcggaggt acagattgtg
    10021 gggcgccaga cggtcgtcgg agcggacgaa cgcttcgggg gccgtaccgt gagccagcgc
    10081 ggcgatggga gccgcctcga tcagtggcct cagcgccgac tgggcgccgg agtaggcgag
    10141 cgcgggccgg ccgaactgcc gcagcagcgc gatgtcggac tcgcgcgcgc tgcgtacggg
    10201 gccgatccgc tgcggcagc
//
