LOCUS       NZ_BMWB01000006        22199 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence06, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000006
VERSION     NZ_BMWB01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 280952)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 57469
            Orig. end                         :: 79668
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22199
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22199
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22199
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12199](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12199
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(201..2351)
                     /gene="ligA"
                     /locus_tag="IE198_RS12330"
                     /old_locus_tag="GCM10010381_24950"
     CDS             complement(201..2351)
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612535.1"
                     /locus_tag="IE198_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24950"
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_373299832.1"
                     /transl_table=11
                     /translation="MFDMTTSPAVAAAPAAVVTDAAAYAEAVETATRAAAAYYATGESP
                     LDDDAYDRLVRGIAAYEQGHPDETSPVSPTGKVAGGAVSGDVAHTVPMLSLDNVFSAEQ
                     LVAWMASVERRTGRPVEEWSVEPKLDGLAIAARYEQGRLTRLVTRGDGTAGEDVSHAIG
                     TIVGLPRQLTEPATLEIRGEVLMTDEQFEQANAARTGHGGAPFANPRNGAAGSLRAKDR
                     EYRVEMTFFGYGALALPGSGAELAAGLGEWAHSRVMRHVAGLGVHTADSTPVAPRTLTK
                     AAEIQDRIDEIAAARPELPFGIDGIVIKADRAEDQTAAGSGSRAPRWAIAYKLPAVEKV
                     TTLLGVEWNVGRTGIIAPRAVLEPVEIDGSTVTYATLHNPADITRRDLRTGDRVMVYKA
                     GDIIPRIEAPVAHLRTGAEQPVVFPEVCPQCGSAIDTSEQRWRCVRGRDCHAVASVSYA
                     AGRDQLDIEGLGTTRVVQLVDAGLVRDFADLFGLTREQLLGLDRMGETSTDNLLAAIAA
                     ARTRPLSRVFCALGVRGTGRSMSRRIARHFATMEHIRAADAEALQQVDGIGVEKARTVV
                     AELAELAPLIDRLTAAGVNMSEPGATYQGAGTVLGTGPEGDDDSGAPMQTAPGAGPLYG
                     MTVVVTGAMTGALEKLSRNQMNELIERAGGKSSSSVSKRTSLLVAGAGAGSKRDKAEQL
                     GTRIAAPDEFAAMVADFLDTAV"
     misc_feature    complement(2333..2353)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            2531..3955
                     /locus_tag="IE198_RS12335"
                     /old_locus_tag="GCM10010381_24960"
     CDS             2531..3955
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948354.1"
                     /locus_tag="IE198_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24960"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189886042.1"
                     /transl_table=11
                     /translation="MPSHVFADRSAQPPERGDVDALITRTRILRGDVDAVRPDGASTED
                     DPQGRWQRALCDLALHHLDDLGAHLGQLKEGLPQEAADAFADELAEYEADGAARTGSLL
                     SRVGSAEWNLLTDEVSWSDELYRILGRDPRSGPMSLDEMPSVVFAEDQPLLTAMVTDCL
                     VDGRPIDGEFRLVRPDGRVRTVHMMGEPVLDADGCTASMWAVLRDVSELRRSQRAVRET
                     MDWLQRRQHMEQTERRIAAEIQEAVLPPRTGFPAGGAALLDIAAHYLPSSKSTLVGGNW
                     YDTLQLPGGDTLLSVGELTGHGVSTTSAVAMLLGALRGMAVAGIRPGPLMTHLNQLLEA
                     SAQPALGSAVCCSYAPSTRTLSWAQAGHPAPLLFRDGTGQALAAPDGVLLGATGGAVYE
                     QAEVALQPGDLLVLHTDGLTRPSAASEVGADRLTALAARFARAEDASGCVRAMLEEFGA
                     QEREGDACVMVARVIG"
     misc_feature    3311..3313
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3998..5491)
                     /locus_tag="IE198_RS12340"
                     /old_locus_tag="GCM10010381_24970"
     CDS             complement(3998..5491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948353.1"
                     /locus_tag="IE198_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24970"
                     /product="hypothetical protein"
                     /protein_id="WP_189885751.1"
                     /transl_table=11
                     /translation="MSREPNTRLCDLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSR
                     VRRWIDMGETPRDPVPKVLAALFTERLGRVVTIEDLGFARSGRTGKRRNVQGTDNPDGL
                     PWAPDRTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSALSSAMHDWLKTDPATPRGAAR
                     TFEVLHTDSAGYDRYEAAPIGSQEIEALERSVEVFRAWDAARGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGEQTLPRTRAMLHTIEAWAQASMGHGQA
                     MRRTLGEAEELFVSDKGDVPPPSWMQMFDEADLHGMQALAYRTLADHEPAAAGIAQKHA
                     KQALQLREGGRQRSKIFDYISLASACFIADDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQYAGYAKIEDLREEIEIALPRGDMPRPRNAEI"
     gene            5726..6847
                     /locus_tag="IE198_RS12345"
                     /old_locus_tag="GCM10010381_24980"
     CDS             5726..6847
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="IE198_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24980"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_189885753.1"
                     /sec_met_domain="APH (E-value: 1.6e-18, bitscore: 61.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRLQQRNAFTAGTGPYPRPVEAGRAPRPAGTVGR
                     PLSGRIDLSGPQGAQLRKAVASVHRICPEFNPVQVLRRSGRSVLIVGTTGRTTAVAKCL
                     LDHSPAWSERLRHEIASYRAFVRHRPPVRVPRLIAADPENCTLVIERMAGRPAALTRHP
                     VEAPPRADLRAVLGAIVRLGSWRPPAGMFDAPLDYGSRISRYHELGLFTDRDLGDLQKL
                     LHGLAQAGGRQGMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWAVLGD
                     APLARRQISQLAQQSGIAARDAFLVNLMLVLTREIRTYETAVQRTMRDASPVPTGQAQP
                     GPAAGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    6035..6037
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7492..7665
                     /locus_tag="IE198_RS12350"
     CDS             7492..7665
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189885755.1"
                     /transl_table=11
                     /translation="MWWSGGGRDISDCVSSPTQSLAMCAGRFRQQIVDRPAAGYVGGGH
                     DDDACLLAVRGG"
     misc_feature    7749..7765
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            7862..9835
                     /locus_tag="IE198_RS12355"
                     /old_locus_tag="GCM10010381_24990"
     CDS             7862..9835
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009313535.1"
                     /locus_tag="IE198_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24990"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_373299850.1"
                     /transl_table=11
                     /translation="MQGSTPPRSGGARRRRALTAGGLVASAALLLPLVSAGPSATAERA
                     PAGSLQEAFAAAADEYGVPESVLLGVSYLQSRWDAHGGAASVTGGYGPMHLTDARTAPA
                     DAPHHAHGSEDARGDDARPARSVVEAALSKAGELPARLRTLERAADVSGIGAEQLRDSA
                     RANVRGGAALLAEAQRELGMPAGQNPADWYGAVARYSGADDVATATAYADDVFDVIRTG
                     QSRTTDSGQRVALAPHPAVAPAREQVRQLGLRTADAGRTECPPTVACEWIPAPYEEFGA
                     GDYGNHDQGNRPASQSVDYIIVHDTEASWDTTLKLVQNPEYVSWQYSLRSSDGHIAQHV
                     PLADVAWHAGNWFVNAKSVGLEHEGFLVSPDAWYTEAMYRASARLVRYLAKRYDIPLDR
                     QHILGHDNVPGTTTSTIRGMHTDPGPYWDWAHYFRLLGKPFTPQAGPSSAVVTVRPEYS
                     EHQPLYTGCVKAGEACAPHGSGAVRLHTGPSGTAPLVKDIGLRPGGQDSTTGVNDTGAR
                     ASTGQQYAVAERRGEWTAIWYLGQKAWFHNPGTQPTAVAAQGAVLTPKDGLAEVPVYGR
                     AYPEASAYPAGVPVQAVSPLPYKLLAGQKYVVGDRVPGEYLYATTFDTAGHRVVRGQEM
                     YYEIQLGHRVAFVKEADVRVLP"
     gene            10001..12199
                     /locus_tag="IE198_RS12360"
                     /old_locus_tag="GCM10010381_25000"
     CDS             10001..12199
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321403.1"
                     /locus_tag="IE198_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25000"
                     /product="terpene synthase family protein"
                     /protein_id="WP_189885759.1"
                     /sec_met_domain="T1TS (E-value: 1.9e-85, bitscore: 281.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFVLPDFYVPYPARLNRHVEEARRHSKKWARGMGMLEGSGIW
                     EESDLDAHDYALLCAYTHPDCDADALGLVTDWYVWVFFFDDHFLEVFKRSQDLAGGKAY
                     LDRLPAFMPMDLSPGTPDPANPVEAGLADLWQRTVPTMSPAWRARFAEATEHLLNESMW
                     ELANIDAGRVANPVEYIEMRRKVGGAPWSAGLVEYAAQAEVPESVAGSRPLRVLRDSFS
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLERFLGCGTQEAAEVVNDLLTSRVQQFENTA
                     LTEVPALCVQKGLAPAECAAIAAYTKGLQDWQSGGHEWHMRSSRYMNEGVENERSRFEG
                     VLGTSALDIRTLFGRPAAARLRTLTHRPQQVGPSWLPEFDLPFPVSLSPHLEQARAASV
                     AWAGRMGLLGDIWDEAKLTGFDFALCSAGLDPDATPEELELSAEWLTWGTYGDDYYPLV
                     FGRSRDLEGARLCNERLKACMPVDEPAAGAAVAVAPMERSLADLWARTAGPMSPGARSS
                     LRSAIDVMLDSWLWELHNQAQHRVPDPVDYIEMRRLTFGSDLTTSLCRLRHEGELPPEL
                     YTSGPVQGLENAAMDYACLINDLFSYQKEIEYEGEVHNAVLVVQTFFDCDRPTAAAMTD
                     ALMRSRLEQFLHTKEHELPLVCEEFGLDEGGRAALDTYVRELEDWLAGILNWHRKVRRY
                     KEEDLRGGAVPRRLGAPSGLGTSAARLSLPSRRSGLGV"
     misc_feature    complement(10002..10017)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            complement(12338..12838)
                     /locus_tag="IE198_RS12365"
                     /old_locus_tag="GCM10010381_25010"
     CDS             complement(12338..12838)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="IE198_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25010"
                     /product="hypothetical protein"
                     /protein_id="WP_189885761.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLFGGRGPAMIIGNLPEGSPAREVAEGEIPFEVGQLLVALENEEQVHVTGIEDT
                     PVMQGDNLLIVRRLKLSESRISCVQFDRSDNVLVTIASWDRPITDDLYALLKPLPAELF
                     QQG"
     gene            13020..13370
                     /locus_tag="IE198_RS12370"
                     /old_locus_tag="GCM10010381_25020"
     CDS             13020..13370
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993741.1"
                     /locus_tag="IE198_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25020"
                     /product="hypothetical protein"
                     /protein_id="WP_189885763.1"
                     /transl_table=11
                     /translation="MNDRTTPALQALPDGEAELRLVVRLHWEDVAALGQEAGRLATQMQ
                     RPVSLDEAAGHRLRTRSAGHAKPTTTPSATPSGSQHLPPASSVSSLTARTPGEHARQAI
                     EKINGTAGSAAM"
     gene            complement(13441..13656)
                     /locus_tag="IE198_RS12375"
                     /old_locus_tag="GCM10010381_25030"
     CDS             complement(13441..13656)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713275.1"
                     /locus_tag="IE198_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25030"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_189886044.1"
                     /transl_table=11
                     /translation="MFSRWEKPDLDLSNADWRSGTQGTGDVQIAFVEGFIAMRNGGRPE
                     NPSLIFTPAEWRAFVLNARDGEFDLT"
     gene            complement(13780..14946)
                     /locus_tag="IE198_RS12380"
                     /old_locus_tag="GCM10010381_25040"
     CDS             complement(13780..14946)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057880.1"
                     /locus_tag="IE198_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25040"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_189885765.1"
                     /transl_table=11
                     /translation="MPAEPVAVVGIGQTKHVAARRDVSIAGLVREAARRALDDAQLTWA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHATVLTLAFEKQSESNAMWGLSLPIPFQQPLLAGAGGFFAPHVRAYVRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHLHEHDITLEKVQASPMLWDPIRYSETCPSSDGACAMVLTDRV
                     GAARSPRPPAWMHGGAMRSEPTMFAGKDFVSPQAGKDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFAAEGEGWKLTESGVTGLDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGQAGEHQVEGARRALGHAYGGGAQFFAMWLVGAEPPAT"
     gene            complement(14936..16012)
                     /locus_tag="IE198_RS12385"
                     /old_locus_tag="GCM10010381_25050"
     CDS             complement(14936..16012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321391.1"
                     /locus_tag="IE198_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25050"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_189885767.1"
                     /transl_table=11
                     /translation="MTRYEAPYGRDIAVVAFAQTCHRRRSDELSEVEMLMPVLHQVLEA
                     TGLRTGDIGFTCSGSSDYLAGRAFSFTMALDGVGAWPPISESHVEMDGAWALYEAWVKL
                     LTGQADTALVYAYGKSSPGEVRDVLTRQLDPYYAAPLWPDSVALAALQAQALIDAGEAG
                     EPELAGVAARSRRAAAANPHAQLQGEVPRGEYHVRPLRVSDCPPVGDGAAAVILAAGER
                     ARELCGRPAWIRGMDHRIEAHALGVRDLTRSPSTRLAAERAGAFRRPVDTAELHAPFTS
                     QEIVLRRSLDLDDRVRVNPSGGALAANPVMAAGLIRIGEAAARIHRGESDRALAHATSG
                     PCLQQNLVAVLEGEADAR"
     gene            complement(16009..16977)
                     /locus_tag="IE198_RS12390"
                     /old_locus_tag="GCM10010381_25060"
     CDS             complement(16009..16977)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="IE198_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25060"
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_189885769.1"
                     /transl_table=11
                     /translation="MPEVLRAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTGDGRV
                     LVPPVEYDPVTAEELRELVEVHATGTVTTWAWNPAPRSQQPLARPFAWVLVRLDGADTA
                     LLHVLDAPGPDAVRTGMRVRVRWAAERTGAITDIACFEPYGSEPAPLPRAHNGSFPRTA
                     AGPAAEAVTGIVAPARLDYTYAPGRAQSDHLAALAERRIVGERCPSCRKIYVPPRGACP
                     TCGVATGEQVEVGPRGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGADLALHGRIGGIP
                     YDEVRMGLRVEPVWHDGARHPDHYRPTGEPDADYDTYKELL"
     gene            complement(16996..17817)
                     /locus_tag="IE198_RS12395"
                     /old_locus_tag="GCM10010381_25070"
     CDS             complement(16996..17817)
                     /NRPS_PKS="Domain: ECH (18-265). E-value: 2.9e-53. Score:
                     172.6. Matches aSDomain:
                     nrpspksdomains_IE198_RS12395_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069072.1"
                     /locus_tag="IE198_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25070"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_189885771.1"
                     /transl_table=11
                     /translation="MDHRSDHRTGTEHLTVARQGATLIVTLNRPEAKNALSIAMLVGLY
                     DAWLAADADDTVRSVVLTGAGGSFCAGMDLKALAGAGMAGERYRDRMKADPDLHWKAML
                     RHHRPRKPVVAAVEGYCVAGGTEILQGTDIRVAGESATFGLFEVRRGLFPIGGSTVRLP
                     RQIARTHALEMLLTGRPYTAAEAERIGLVGRVVPDGTALDAALDVAERINGCGPLAVEA
                     VKASVYETAEMTETDGLAAELKRGWPVFDTADAKEGARAFAEKRDPVYRRA"
     aSDomain        complement(17023..17763)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS12395_ECH.1"
                     /evalue="2.90E-53"
                     /label="IE198_RS12395_ECH.1"
                     /locus_tag="IE198_RS12395"
                     /protein_end="265"
                     /protein_start="18"
                     /score="172.6"
                     /tool="antismash"
                     /translation="QGATLIVTLNRPEAKNALSIAMLVGLYDAWLAADADDTVRSVVLT
                     GAGGSFCAGMDLKALAGAGMAGERYRDRMKADPDLHWKAMLRHHRPRKPVVAAVEGYCV
                     AGGTEILQGTDIRVAGESATFGLFEVRRGLFPIGGSTVRLPRQIARTHALEMLLTGRPY
                     TAAEAERIGLVGRVVPDGTALDAALDVAERINGCGPLAVEAVKASVYETAEMTETDGLA
                     AELKRGWPVFDTADAKEGARAFAEK"
     misc_feature    17872..17887
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    17873..17889
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    17877..17891
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.63"
                     /tool="antismash"
     gene            17978..19624
                     /locus_tag="IE198_RS12400"
                     /old_locus_tag="GCM10010381_25080"
     CDS             17978..19624
                     /NRPS_PKS="Domain: AMP-binding (8-438). E-value: 2.1e-64.
                     Score: 209.5. Matches aSDomain:
                     nrpspksdomains_IE198_RS12400_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761827.1"
                     /locus_tag="IE198_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25080"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_189885773.1"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-70, bitscore:
                     229.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALVYIDHPGTGAQRRLRYAELDAAA
                     NRIAHHLLGAGIGPGEHLGLHLYNGIEYLQTVLGCLKARIVPVNVNYRYVEDELVHLYR
                     DADLAALVFDAEFTERVAAVLPRTERLRHLVRVGTPPEGVLRLDAVDFADAEAAGSPRR
                     GFAPRSADDRFIIYTGGTTGMPKGVMWRQEDLFFAGLGGGAPTGEPVSRPDELAERVAA
                     GGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVLHRKFVPHEVLRTIEREKVTSVSLVG
                     DAMLRPLIDALKGPLKGCDLSALFSVSSSGAIMSDVVRKEFGALAPGVLLLNNFGSSES
                     GFNGTATDDSGPARGFRLRVNARTTVVDPATYEPVKPGRTGRVAQRGHVPLGYYKDPAK
                     SAETFFERDGERWVLLGDMATVDEDGIVTVLGRGSQCINTGGEKVYPEEVEQALKAHPD
                     VYDALVAGVPDRTWGNQVAAVVQLRKGAPAPSLDAIRSHCRSRLAGYKIPRQLVVAEEI
                     RRSPSGKADYRWARAVASEAAGAAGLTENRC"
     aSDomain        18002..19291
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS12400_AMP-binding.1"
                     /evalue="2.10E-64"
                     /label="IE198_RS12400_AMP-binding.1"
                     /locus_tag="IE198_RS12400"
                     /protein_end="438"
                     /protein_start="8"
                     /score="209.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALVYIDHPGTGAQRRLRYAELDAAANRIAHHLL
                     GAGIGPGEHLGLHLYNGIEYLQTVLGCLKARIVPVNVNYRYVEDELVHLYRDADLAALV
                     FDAEFTERVAAVLPRTERLRHLVRVGTPPEGVLRLDAVDFADAEAAGSPRRGFAPRSAD
                     DRFIIYTGGTTGMPKGVMWRQEDLFFAGLGGGAPTGEPVSRPDELAERVAAGGDGITFF
                     PTPPLMHGTSTLTAFIGFNFGQRVVLHRKFVPHEVLRTIEREKVTSVSLVGDAMLRPLI
                     DALKGPLKGCDLSALFSVSSSGAIMSDVVRKEFGALAPGVLLLNNFGSSESGFNGTATD
                     DSGPARGFRLRVNARTTVVDPATYEPVKPGRTGRVAQRGHVPLGYYKDPAKSAETFFER
                     DGERWVLLGDMATVDEDGIVTVLGRGSQCIN"
     misc_feature    18003..18018
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.03"
                     /tool="antismash"
     CDS_motif       18497..18547
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS12400_0001"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="IE198_RS12400"
                     /protein_end="190"
                     /protein_start="173"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     gene            complement(19644..20174)
                     /locus_tag="IE198_RS12405"
                     /old_locus_tag="GCM10010381_25090"
     CDS             complement(19644..20174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018556804.1"
                     /locus_tag="IE198_RS12405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_25090"
                     /product="VOC family protein"
                     /protein_id="WP_189885774.1"
                     /transl_table=11
                     /translation="MPQPEGAELEALRARREELRRQYLRAPDDRPATTTRGIHHVAFIC
                     RDVEETIRFYQEFLGFPLVEIVENRDYRGSTHFFFDIGNGNLLGFFDFPGHDHPAATET
                     IGGVQHMALSVDASRFGAAREALDAAGVEYVGPDRGVEDSLYIHDPNGVPLELYQERLG
                     VFNGERILPGDGD"
     misc_feature    20722..20736
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(21069..21084)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    21882..21898
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.15"
                     /tool="antismash"
ORIGIN
        1 gtggtgcaac cggcgcgcgc aacgagaagg ccatcgcccg tacggtccgc tccggcttcg
       61 tcctcggacc gaggtggacg acccggagaa gcgggcccgg ctcaccttcc cccgaccgcg
      121 ccgccttcga gcggcctgtt ccgggcgcct cgccggaacg gggtgggcgg gttcggccgt
      181 acccgccttc cccctccgct tcacacggcc gtgtcgagga agtccgccac catggcggcg
      241 aactcgtccg gcgcggcgat ccgggtgccc agttgctcgg ccttgtccct cttggagccg
      301 gcgcctgctc cggcgaccag gagggacgtg cgcttggaca cgctcgagga cgacttgccg
      361 ccggcccgct cgatgagctc gttcatctgg ttgcggctca atttctccag cgcgcccgtc
      421 atcgcgccgg tcaccacgac ggtcatgccg tacaaggggc cggcgcccgg tgccgtctgc
      481 atgggcgcgc cggagtcatc gtccccttcg gggccggtac cgagcacggt cccggcgccc
      541 tggtacgtcg cacccggctc gctcatgttg acgcccgcgg ccgtcagccg gtcgatcagc
      601 ggggccagct cagccagttc ggccaccacc gtccgggcct tctccacgcc gatgccgtcg
      661 acctgttgca gggcctcggc gtcggcagcc cgtatgtgct ccatggtggc gaagtgccgg
      721 gcgatccggc gggacatgga gcggccggtg ccacgcacgc cgagggcgca gaacacccgt
      781 gacagcggcc gggtccttgc cgcggcgatg gcggccagca gattgtcggt gctggtctcg
      841 cccatccggt ccagcccgag cagttgctca cgggtgaggc cgaacaggtc ggcgaagtcg
      901 cggaccagac cggcgtcgac gagctggacg acgcgggtgg tgccgagccc ttcgatgtcg
      961 agctggtcgc gccccgccgc gtaggagacg gaggcgacgg catggcagtc acgcccgcgg
     1021 acgcatcgcc agcgctgctc cgaggtgtcg atggccgagc cgcactgagg gcacacctcg
     1081 gggaagacga cgggctgctc ggcgccggtg cgcagatggg cgacgggcgc ctcgatgcgg
     1141 gggatgatgt cgcccgcctt gtagaccatc acccggtccc ctgtgcgcag atcgcggcgg
     1201 gtgatgtcgg cggggttgtg cagggtcgcg taggtgacgg tcgatccgtc gatctccacc
     1261 ggctcgagca cggcacgcgg cgcgatgatt ccggtgcggc ccacgttcca ttcgacgccg
     1321 agcagggtgg tgaccttctc cacggcgggc agcttgtagg cgatggccca ccggggcgca
     1381 cgggaacccg agccggccgc tgtctggtcc tcggcccggt ccgccttgat cacgatcccg
     1441 tcgatgccga acggcagctc cgggcgggcg gcggcgatct cgtcgatgcg gtcctggatc
     1501 tccgcggcct tggtcagggt gcgcggggcg accggggtgc tgtcggcggt gtgcacaccg
     1561 agccccgcca catgacgcat cacccgactg tgcgcccact cgccgagtcc ggcggcgagc
     1621 tcggcgccgg agccgggcag cgccagcgcc ccgtagccga agaaggtcat ctccaccctg
     1681 tactcacggt ccttggcgcg caggctgccc gccgcgccat tgcgcggatt ggcgaagggc
     1741 gcgccgccgt gcccggtgcg tgcggcgttc gcctgctcga actgttcgtc ggtcatcagt
     1801 acttcgccgc ggatctcgag cgtggccggc tcggtcagct gccggggcag accgacgatc
     1861 gtgccgatcg cgtgcgagac gtcctcaccg gccgtgccgt ccccgcgggt gacgagccgg
     1921 gtgaggcggc cctgctcgta ccgcgcggcg atggcgaggc cgtccagctt gggttcgaca
     1981 ctccactcct cgacgggccg gcctgtgcgc cgctccacgg aagccatcca ggcgacgagc
     2041 tgctccgcgg agaagacgtt gtccagggaa agcatcggaa ccgtgtgcgc gacgtcgccg
     2101 gacaccgcgc cgcccgccac cttgccggtc ggggagaccg gcgatgtctc gtcggggtgc
     2161 ccctgctcgt acgcagcgat cccgcgcacc aggcggtcgt acgcgtcgtc gtccaggggg
     2221 ctctcgccgg tggcgtaata cgcggcggcg gcgcgggtcg cggtctcgac cgcctcggcg
     2281 tacgcggcgg cgtcggtgac cacggcggcg ggcgcggcag caacggcagg tgaagtcgtc
     2341 atgtcgaaca tactgccgcc ccccactgac aacggccggg gccaggcccc ggacgcctgt
     2401 ggcacatgac agaggcacca ccggatcgag tgttgccaaa tgacttacgg cccctcgctc
     2461 cctgtgcaac agtcgtaccc ggtccctgtc ccagaccctg gccgtggccg cgtttgtatc
     2521 ggagtacgac atgccgtccc atgtgttcgc ggaccgctcc gcccagccac ccgagcgcgg
     2581 agacgtcgac gcgctgatca cccggacgcg catactccgt ggggacgtcg acgcggtgcg
     2641 cccggacggc gcatcgacgg aggacgaccc gcagggccgc tggcagcgcg ccctgtgcga
     2701 cctggcgctc catcatctcg acgatctggg cgcccacttg gggcagctga aggaagggct
     2761 tccccaagag gcggccgacg cgttcgccga cgagctcgcc gagtacgagg ccgacggcgc
     2821 ggcccgcacc ggctcgctgc tcagccgggt cggcagcgcc gagtggaacc tcctcaccga
     2881 cgaggtgagc tggtccgacg agctgtaccg gatcctgggg cgcgatcctc gcagcgggcc
     2941 catgtcgctg gacgagatgc cgtccgtggt gttcgcggag gaccagccgc tgctgaccgc
     3001 catggtgacg gactgtcttg tcgacggccg ccccatcgac ggcgagttcc gtctcgtacg
     3061 gcccgacggc cgggtgcgca ccgtgcacat gatgggcgag ccggtgctcg acgcggacgg
     3121 gtgcaccgcg tcgatgtggg ccgtcctgcg ggacgtcagc gaactgcgcc gcagccagcg
     3181 ggccgtgcgg gagaccatgg actggttgca gcggcggcag cacatggagc agaccgagcg
     3241 ccggatcgcg gccgagattc aggaagcggt gctccctccg cgcaccggct tccctgcagg
     3301 tggcgccgcg ttactggaca tcgcggccca ctacctcccc tcctcgaaga gcacgctcgt
     3361 cggcggcaac tggtacgaca cgctccaact gccgggcggt gacacgctct tgagcgtcgg
     3421 cgaactgacc ggccatggag tgagcaccac gtccgccgtg gcgatgctgc tgggcgcgct
     3481 gcgcggcatg gccgtggccg gcatccggcc ggggccgctg atgacgcacc tcaaccaact
     3541 gctcgaagcc tcagcacagc ccgccctcgg cagcgcggtc tgctgcagtt acgcgccttc
     3601 gacccggacc ctctcgtggg cgcaggctgg acaccccgcc cctctgctgt tccgcgacgg
     3661 cacggggcag gcgctggcgg cgccggacgg cgtactcctc ggtgcgaccg gcggcgcggt
     3721 gtacgagcag gccgaagtcg ccctccagcc cggcgatctg ctggtgctgc acaccgacgg
     3781 cctgacccgc ccgagcgctg cgtccgaggt cggcgcggac cggctgacgg cattggcagc
     3841 acggttcgcc cgagccgagg acgcgtcggg atgcgttcgt gcgatgctcg aggagttcgg
     3901 tgcgcaggag cgcgaggggg acgcctgtgt gatggtggca agggtcatcg ggtagctgcc
     3961 ggccgcggta cggccgaggg ggcagatccc gtgagggtca gatctccgcg ttcctcggcc
     4021 tcggcatgtc gccgcgaggc agcgcgatct cgatctcctc acgaaggtcc tcgatcttcg
     4081 cgtatccggc gtactgcccg gtgagacggt acatctcgcg cagcctgtcc caggtccggt
     4141 gcgaggaggt ctcccccatc gacaccagcg cgagccgggc gtaacggtcg gcctgctcag
     4201 ggtcgtcggc gatgaaacac gcggaggcca gcgagatgta gtcgaagatc ttcgagcgct
     4261 gacggccgcc ctcgcgcaac tgcagcgcct gcttggcatg tttctgcgcg ataccggccg
     4321 ccgccggctc gtggtcggcg agcgtgcggt acgccagcgc ctgcatgccg tggaggtcgg
     4381 cctcgtcgaa catctgcatc cagctgggcg ggggaacatc gcccttgtcg gagacgaaca
     4441 gctcctccgc ctcgccgagg gtgcggcgca tggcctgacc gtggcccatg gacgcctgcg
     4501 cccaggcctc gatggtgtgc agcatcgcgc gggtgcgcgg cagggtctgt tccccggagc
     4561 cggacttggc gagcttcatc aggtcgagcg cgtcgtccgg gcggcccaga tggaccatct
     4621 ggcgggccgc acgcgacagc gcctcaccgg cgcggggccg gtcgccgcct tctctggccg
     4681 catgggcggc gatgacgaag tacttctggg cggtgggttc gaggccgacg tcgtgggaca
     4741 tccagccggc gagcaccgcg aggttggcgg cgacgcccca caggcgccgc tggaggtggt
     4801 cggggtgccg gtaggcgagc atgccgccca cctcgttgag ctgtcccacc accgctttac
     4861 gctgcagtcc gccgccgcgg gcggcgtccc aggcgcggaa cacctcgacg gaacgctcca
     4921 gcgcctcgat ctcctgcgac ccgatggggg cggcctcgta gcggtcgtac ccggcggagt
     4981 cggtgtgcag aacttcaaag gtgcgggcgg cgccccgggg cgtcgccgga tcggtcttga
     5041 gccagtcgtg catggcgctg ctgagtgctg agcccgcggc aagcgccgcg cccgcgccca
     5101 ccaggccgcg tcggttgagc atgaggtcca ttcccgtgaa ttcggtgagg accgccgccg
     5161 tacggtcggg cgcccagggc agaccgtcag ggttgtcggt gccctggacg ttccgccgct
     5221 tacccgttcg cccgctccgt gcgaacccga ggtcctcgat ggtcacgaca cgaccgagtc
     5281 gctcggtgaa cagagctgcc agcaccttgg gcacgggatc gcgcggggtc tcccccatgt
     5341 cgatccaacg ccggacccgc gaagtgtcgg tcgccagctg cggatggccc atggcggccg
     5401 cctgccggtt cacgagtctt gcgagctccc ccttggacca gccggccagg ccgaacaagt
     5461 cgcacaggcg ggtgttgggt tctctgctca cgtcaagccc ccaggttctc ggctgagttg
     5521 acactaaccc gccggcatgg ggcgggcgac tattcgccag ggttcgccag ggttcgccag
     5581 atggtgtgcc acccgcgacg cggtgtcagg tatgaatgcg ccacctcgtc ccctctgccg
     5641 ggggcacatt ccccagggtg ttacccatgg catatggggc ggggccgcgc acgcaactgt
     5701 cggcacacga agggatctgt ctcccatgta cacagcatcg tcctccgtgt ccgccccgcc
     5761 ccggctgcag cagcgcaacg cgttcacggc cggcaccgga ccgtatcccc ggcccgtcga
     5821 ggccggccgg gcgcccagac cggccggcac cgtcggccgc cccctcagcg ggagaatcga
     5881 cttgtccggc cctcagggcg cgcagctgcg caaggctgtc gcgtcggtgc accggatctg
     5941 cccggagttc aacccggtgc aggtcctgcg ccgcagcgga cgatccgtgc tgatcgtcgg
     6001 aacgacgggg cgtaccacgg cggtcgccaa gtgcttactg gaccactcgc cggcgtggtc
     6061 cgagcggctg cgccacgaaa tagcgtccta ccgcgccttc gtgcggcacc ggccgccggt
     6121 gcgggtcccg cgactcatcg cggcggaccc ggagaactgc acgctggtga tcgagcggat
     6181 ggcgggacgg cccgcggccc tgacccggca tccggtggag gccccgcccc gtgcggacct
     6241 gcgcgccgtg ctgggcgcga tcgtacggct gggcagctgg cgcccgccgg ccgggatgtt
     6301 cgacgccccg ctggactacg ggtcgcggat ctcgcgttac cacgagctgg ggctgttcac
     6361 cgaccgggac ctgggcgacc tgcagaagct gctgcacggt ctggcacagg ccgggggcag
     6421 gcagggaatg gggcagttct gtcacgggga cgcactgctc tccaacatcc tgctgtcgcc
     6481 cacgggtcct gtgctggtcg actgggagca cgccggctgg tatctgcccg gctacgacct
     6541 ggcgacgctg tgggcagtgc tgggggacgc ccccctggcg cggcgtcaga tcagccagct
     6601 ggcacagcag tcgggcatcg cggcccggga cgcgttcctg gtcaatctga tgctggtgct
     6661 gacccgggag atccgtacct acgagacggc ggtgcagcgc accatgcgcg acgcgtcgcc
     6721 ggtcccgacc ggccaggcgc agcccggccc ggccgcgggt gaggaacagc ggctgctgct
     6781 gcggaggttg cacgacgact gcgcgatggc ccgcagggcc gtgcgtgcgg cggtcggcac
     6841 ccgctgaccc accaccgcag agggaaggcg cgctgcgcgt ccggtgttcg acacaccggg
     6901 cgcgcagcgc agcgagtgtc gggcaccgac cgaggatcgg cggtgtgtcc tctgcggcag
     6961 caggcgcagc ggggcaccgc tgctgccggt gtccgggtgg ccgctccggg cctgtccggt
     7021 ccctcgcgtc cccctgagcc ccgcgtatct gacggccgaa cccgaacgcg gcggtgggcg
     7081 gtgactggta caagtgccgt ccgctgccca gcgggcaggc gctgtggtca tcgggcgcga
     7141 gccgccacca tcccggtggg tggtcaggtg ggccggcagt ggtatgcgat ggccggactc
     7201 gcccacacgg aacggccatc ttggcgatgc cgccacgtgg gtgaatgacc tgctggccgg
     7261 ctacccctcc gcgtccactg cgaccgtgat ttgccgggca catcacggac gagcgggtgc
     7321 cgggccgggg gtgtgccggt cacgcggcgc ccctgttgct gcgcggcgac cgcgcgattt
     7381 tgctgccggt ggcccatcgc ggcccggtgc cggtggcgct gccgggtcac cgtgacgagg
     7441 cgctggactt cgcaccggaa gcggggacgt gctgctgctg tacacccgac cgtgtggtgg
     7501 agcgggggcg gcagggacat cagcgactgc gtcagctcgc cgacgcagtc gctggcgatg
     7561 tgtgcgggcc gcttccggca gcagatcgtg gaccggccgg cggctggtta cgtcggcggc
     7621 gggcatgacg acgacgcctg tctcctggcg gtccggggcg gctgaacacc tcggccattg
     7681 gtccacgcca ctggcgcgcc gcagcccggc gcaccgtcgt cgcgaaaccc gccgggaccc
     7741 gcgttgacgt gcaaatttcc tacggcgaag catgattgac ggatcgtccg ggagcggata
     7801 cccatgggtc gtgtccggcc ccgcaggtcc cgtcgcgcac cactcgtcac tggaggctgc
     7861 attgcaagga tcgactcccc cacggtcagg cggtgcccgc cgtcgtcgcg cgttgacggc
     7921 gggaggcctg gtggcgagcg ccgccctgct gctgccgttg gtgtccgccg gtccgtcggc
     7981 gactgccgaa cgggccccgg ccggttcgct gcaggaggcc ttcgccgccg cggccgacga
     8041 gtacggggtg ccggagagtg tgcttctcgg tgtctcctat ctgcagtccc gctgggacgc
     8101 gcacggcggc gcggcgagtg tcaccggcgg ctacggcccg atgcatctga ccgacgcgag
     8161 gacggcgccg gccgatgccc cgcatcatgc gcacggcagt gaggacgccc gcggggacga
     8221 cgcgcgtccg gcccgttccg tcgtcgaggc ggcgctgtcg aaggccgggg aactgccggc
     8281 gcggctgcgg acgctggaac gcgcggccga cgtgtcgggc atcggcgcgg agcagttgcg
     8341 ggacagcgcc cgggccaacg tacgcggcgg tgcggcgctg ctcgccgaag cgcagcgcga
     8401 actgggcatg ccggccggcc agaatccggc agactggtac ggcgccgtgg ccaggtactc
     8461 cggcgcggac gacgtggcga cggcgacggc ctacgcggac gacgtcttcg acgtgatccg
     8521 cacggggcag tcgcggacca ccgacagcgg tcagcgggtg gcgctcgcgc cgcacccggc
     8581 ggtggcgccc gcgcgtgaac aggtgcggca gttggggctg cgcaccgccg acgcgggcag
     8641 gaccgagtgt ccacccacgg tggcgtgcga gtggatcccg gcaccgtacg aggagttcgg
     8701 cgcaggcgac tacggcaacc acgaccaggg aaaccggccg gcgtcccagt cggtggacta
     8761 catcatcgtc catgacacgg aggcctcctg ggacaccacc ctgaaactgg tgcagaaccc
     8821 ggaatacgtg tcgtggcagt actcactgcg ttcgtcggac gggcacatcg cgcagcacgt
     8881 cccgctcgcg gacgtcgcct ggcacgccgg caactggttc gtcaacgcca agtcggtggg
     8941 cctggagcac gagggattcc tggtgtcccc tgacgcctgg tacaccgagg cgatgtaccg
     9001 cgcttcggcg cggctggtga ggtacctggc caagcggtac gacatcccgc tggaccgcca
     9061 gcacatcctg ggccacgaca atgtgccggg cacgacgact tccacgatcc gcggaatgca
     9121 caccgacccc gggccgtact gggactgggc gcactacttc cggctgctgg gcaagccgtt
     9181 cacgccgcag gcggggccga gcagcgcggt ggtcaccgtc cgtcccgagt actcggagca
     9241 ccagccgctc tacacgggct gcgtcaaggc cggtgaggcg tgtgcgccgc acggttccgg
     9301 tgcggtgcga ctgcacaccg ggccgagcgg gaccgctccg ctcgtcaagg acatcggtct
     9361 gcggccgggc ggccaggact cgacgaccgg cgtgaacgac acgggggcgc gggcgtcgac
     9421 cggtcagcag tacgcggtgg cggagcgccg gggcgagtgg acggcgatct ggtacctggg
     9481 gcagaaggcg tggttccaca acccgggcac gcaaccgacg gcggttgccg cgcagggggc
     9541 ggtgctgacg ccgaaggacg gtctcgcgga ggtgccggtg tacgggaggg cctatccgga
     9601 ggcgtcggcc tatccggcgg gtgttccggt gcaggcggtc tcgccgcttc cgtacaagct
     9661 gctcgcgggg cagaagtacg tggtcggtga ccgggtgccg ggcgagtacc tgtacgcgac
     9721 gacgttcgac acggcaggcc accgggtggt gcggggccag gagatgtact acgagatcca
     9781 gttggggcac cgagtggcgt ttgtgaagga agccgacgtg cgggtgctcc cgtaggccgc
     9841 ggggcgccac cggtcgtggg gtccggtggc gccccgttcc tcttggctgc ttatgtgagt
     9901 aattgccggg gtgcgtgggc cgtacgggcg aagggtaggg ctgggccgtc atgaccggtc
     9961 cgcgccctgt gcgcggcttt tccgaaaggc cctggcgcac atggcacagc ccttcgtact
    10021 gccggacttc tacgttccgt atccggcccg cctcaaccgg catgtcgagg aggcgcggcg
    10081 gcacagcaag aagtgggcac gcgggatggg gatgctggag gggtccggca tctgggagga
    10141 gagcgacctc gacgcgcacg actacgccct gctgtgcgcg tacacccacc cggactgcga
    10201 cgccgatgcc ctcggcctgg tcaccgactg gtacgtgtgg gtcttcttct tcgacgacca
    10261 cttcctcgag gtcttcaagc gcagccagga cctggccggc ggcaaggcgt atctggaccg
    10321 gctgccggcg ttcatgccga tggacctgtc gccgggcacg ccggatccgg cgaacccggt
    10381 ggaggccggg ctcgccgatc tgtggcagcg gactgtgccc accatgtcgc ccgcctggcg
    10441 ggcccggttc gccgaggcca cggagcatct tctcaacgag tcgatgtggg agctcgccaa
    10501 catcgacgca ggcagggtcg ccaatccggt cgagtacatc gagatgcgcc ggaaggtcgg
    10561 cggcgccccc tggtccgccg gtctggtgga gtacgcggca caggccgagg taccggagtc
    10621 ggtggcgggc tcccgtccgc tgcgggtgct gcgtgactcc ttctccgacg cggtgcatct
    10681 gcgcaacgac ctcttctcgt accaacgcga ggtggaggac gagggcgaga acagcaacgg
    10741 tgtgctggtg ctggagcggt tcctgggctg cggcacgcag gaggcggcgg aggtggtcaa
    10801 cgacctgctg acctcacggg tccagcagtt cgagaacacc gcgctcaccg aagtgccggc
    10861 cctgtgcgtc cagaagggcc tggctccggc ggagtgtgcg gcgatcgccg cctataccaa
    10921 gggacttcag gactggcagt ccggcggcca cgagtggcac atgcgctcca gccgctacat
    10981 gaacgagggc gtggagaacg agcgctcgcg cttcgagggg gtgctgggca catcggcgct
    11041 ggacatccgg acgcttttcg gccgtcccgc tgcggcgcgg ctgcgcacac tcacccaccg
    11101 gccgcagcag gtggggcctt cgtggctgcc cgagttcgac ctgccgttcc cggtgtcgct
    11161 cagcccccat ctggagcagg cccgcgccgc ctccgtcgcc tgggccggcc ggatgggcct
    11221 gctgggggac atctgggacg aggcgaagct gaccggcttc gacttcgcac tgtgctccgc
    11281 ggggctcgac ccggacgcca cgccggagga gctggagctc agtgccgagt ggctgacctg
    11341 ggggacgtac ggcgacgact actatccgct ggttttcgga cgctcccgcg atctggaggg
    11401 tgccaggctg tgcaacgagc ggctcaaggc ctgcatgccc gtggacgaac cggcggccgg
    11461 cgccgccgtc gcggtagccc ccatggagcg cagtctggcc gatctgtggg ctcgcaccgc
    11521 cgggccgatg tctcccggcg cccggtcctc gctgcggagc gcgatcgacg tgatgctgga
    11581 cagctggctg tgggagctcc acaaccaggc ccagcaccgg gtccccgatc cggtcgacta
    11641 catcgagatg cggcggctga ccttcggctc ggacctgacc acgagtctgt gcaggctgcg
    11701 gcacgagggc gagctgccgc cggagctcta cacgagcggg ccggtgcagg gcctggagaa
    11761 cgcggccatg gactacgcct gcctgatcaa cgacctcttc tcgtaccaga aggagatcga
    11821 gtacgaggga gaggtgcaca acgcggtgct ggtggtgcag acgttcttcg actgcgaccg
    11881 tccgacggcc gccgcgatga ccgacgctct catgcggtcc cggctggagc agttcctgca
    11941 tacgaaggaa catgaacttc ctctggtgtg cgaggagttc ggcctggacg aggggggcag
    12001 ggcggccctt gacacctatg tgagggagct cgaggactgg ctcgcgggca tcctcaactg
    12061 gcaccggaag gtgcggcgtt acaaggagga ggatctgcgg ggcggcgcgg taccgaggcg
    12121 gctgggggca ccctcggggc tgggcacgtc ggccgcccgg ctgtcgctgc cgagccggcg
    12181 gtcggggctc ggggtgtagg gcctgcccga ccctgctccg ccggacaggc tctgcggccg
    12241 gtggactgcg cagccgcccg gcgatggggt ctcacgtcac aggactgcct gggccgccgg
    12301 gccccggcag tgcgtcggac ggggatcccg ggcggcgtca gccctgctgg aacagctccg
    12361 cgggcagcgg cttgagcagc gcgtagaggt cgtcggtgat cggccggtcc cagctggcga
    12421 tggtgacgag cacattgtcg ctgcggtcga actggacgca ggagatgcgg ctttccgaga
    12481 gcttcagccg gcgcacgatc agcaggttgt ccccttgcat gaccggcgtg tcctcgatgc
    12541 cggtgacatg gacctgctcc tcgttctcca gcgcgacgag cagttggccc acctcgaagg
    12601 ggatctcccc ctccgcgacc tcgcgggccg gcgagccctc cggaaggttg ccgatgatca
    12661 tcgcggggcc gcggccgccg aagaggtcgt agcgcaggaa gacgccctga cagcttccgt
    12721 ccggggcggg cagcagtccg gcgccgagat ttccgggcca gtcccccggg tccatggcca
    12781 ggacgtcgaa gtccgggccc gcgggtgtgg cggcgctgcg gcggcggagg aaggacataa
    12841 ccgcaatggt acgggtacgg acggagtcgg ccgagccggg gcgggggccc gttgaacgcg
    12901 gcggccgccg tcctcgtatc cctgggagca ccggtccccc acggccggtg ccggtgagta
    12961 ccgacgcctg tgaggagcgc gttccagccg ggattccgta ccgacgtgag gatcagtcca
    13021 tgaacgaccg caccactcca gccctgcaag ccctccccga cggcgaggcg gaactgcgtc
    13081 tggtggtccg cctccactgg gaggacgtcg ccgcgctcgg gcaggaagcc ggccggctgg
    13141 cgacccagat gcagcgaccc gtgagcctcg acgaggcagc cggtcaccgg ctgcgcaccc
    13201 gctccgcggg ccacgccaag ccgacgacga cgccctcggc cacgccctcg ggcagccagc
    13261 acctgccgcc ggcgtcgtcc gtctcctccc tcaccgcccg cacgcccggt gagcatgccc
    13321 ggcaggccat cgagaagatc aacggcacgg cggggtcggc cgcgatgtga cgcggacgtc
    13381 cgcccgagcg ggcctgctcc ccctcccacg ccggcgggag ggggcccggg ccgggcgccg
    13441 tcaggtgagg tcgaactcgc cgtcccgcgc gttcagcacg aaggcacgcc actcggccgg
    13501 ggtgaagatc agcgacgggt tctccggacg gccgccgttg cgcatcgcga tgaacccttc
    13561 gacgaacgcg atctgcacgt ccccggtgcc ctgagtaccc gaacgccagt ccgcgttgct
    13621 caggtcgagg tccggcttct cccacctcga aaacatgtgc gtggttgtgg tggtggtgct
    13681 ctcggccacg tccctgctcc tcccgcgtcg tctccggggc cagcctagcg atggcacccc
    13741 gtcacggaca gggtgccgcg cgtgacggtg cggcggcgat caggtggcag gcggctcggc
    13801 gccgaccagc cacatggcga agaactgcgc gccgccccca tatgcgtgtc cgagggccct
    13861 gcgtgcgccc tcgacctggt gctcgcccgc ctggccgcgc acctggagcg cggcctcagc
    13921 gaagcggatc atgccggacg ccccgatggg attggtcgac agcaccccgc cggacggatt
    13981 gacgggcagg tcaccgtcga gtccggtcac accggactcg gtgagcttcc atccttcacc
    14041 ctcggcggcg aagcccaggt tctccaacca catcggctca taccaggaga acggcacata
    14101 catctccacc gcgtcgatct cgcggcgggg gtccgtgatg ccggcctgtc ggtagacgtc
    14161 ggcggcgcag tccttgcctg cctgcggtga cacgaagtcc ttgcccgcga acatggtggg
    14221 ctcgctgcgc atcgcgccgc cgtgcatcca tgcgggcgga cggggcgaac gggcggcgcc
    14281 cacccggtcg gtgaggacca tcgcgcacgc cccgtcggag gatgggcagg tctccgagta
    14341 gcggatcggg tcccacagca tcggcgacgc ctggaccttc tcaagggtga tgtcgtgctc
    14401 gtgcaggtgc gcgtacgggt tcttcagagc gttgcggcgg tccttgtacg cgacgaggga
    14461 gccgaccgtg tcgggcgctc cggtgcgtcg cacataggcg cgcacatgcg gggcgaagaa
    14521 gccgcccgcg ccggcgagca gcggctgctg gaaggggatc ggcagggaca acccccacat
    14581 ggcgttggac tcggactgct tctcgaaggc cagggtgagc accgtcgcgt gcacgcgcgc
    14641 ggccacaagg ttggcggcga cgagggcggt ggagccgccg acggaccccg cggtatggac
    14701 gcggagcatc ggcttgccga cggcaccgag ggcgtcggcc aggtacagct ccggcatcat
    14761 cacgccctcg aagaagtcgg gtgccttgcc gatgacgacg gcgtcgatgt cggcccaggt
    14821 cagttgggcg tcgtcgaggg cccgccgggc ggcctcgcgc accagtccgg cgatggagac
    14881 gtccctgcgc gctgcgacgt gcttcgtctg gccgatgccc acgacggcca cgggttcagc
    14941 gggcatcggc ctctccttca aggacggcga ccaggttctg ctggaggcag gggccggagg
    15001 tggcgtgggc cagggcccgg tcggactcgc cgcggtggat ccgggcagcg gcctcgccga
    15061 tcctgatcag accggcggcc atcaccgggt tggcggcaag tgctccgccg gacgggttga
    15121 ccctcaccct gtcgtcgagg tcgagactgc ggcgcagcac gatctcctgg gaggtgaacg
    15181 gggcgtgcag ctccgccgtg tcgacagggc gccggaaggc gccggcccgc tctgccgcga
    15241 gcctggtgga gggcgaacgg gtgaggtccc gcacaccgag ggcgtgtgcc tcgattcgat
    15301 ggtccatgcc gcggatccag gccggccgcc cgcacagctc acgggcccgc tcaccggcgg
    15361 ccaggatcac ggcggccgcg ccgtcgccga cgggcgggca gtcggagacc ctcagcggcc
    15421 tgacgtggta ctcgcctcgc ggaacctctc cctgaagttg agcgtgcggg ttggccgcgg
    15481 cagcacggcg gctgcgggcc gcgacgccgg cgagctccgg ttcaccggcc tcgcccgcgt
    15541 cgatcagtgc ctgcgcctgc agggcggcga gagcgacgga gtcgggccag aggggggccg
    15601 cgtagtaggg gtcgagttgc cgggtgagca cgtcgcggac ctcgccgggc gacgacttgc
    15661 cgtacgcgta gacgagcgct gtgtccgcct gaccggtcag cagcttcacc cacgcctcgt
    15721 acagcgccca ggcgccgtcc atttcgacgt gcgactcgct gatcgggggc caggcgccga
    15781 ccccgtcgag cgccatggtg aaggagaacg cccggcccgc gaggtagtcg ctggatcccg
    15841 agcacgtgaa tccgatgtcg ccggtccgca gcccggttgc ctcgagcacc tggtgcagca
    15901 ccggcatcag catctcgacc tcggacagct cgtcgctgcg gcgccgatga caggtctggg
    15961 cgaaggcgac aacggcgatg tccctgccgt acggggcctc gtaccgcgtc acagcagctc
    16021 cttgtaggtg tcgtagtcgg cgtccggttc gccggtgggc cggtagtggt cgggatgtcg
    16081 ggccccgtca tgccagaccg gttcgacgcg caggcccatg cgcacctcgt cgtaggggat
    16141 gccgccgatg cgtccgtgga gcgcgaggtc cgcgccgtcg agggcgatgt gggcgtagac
    16201 gtaggggacc tcgatgtcga gattcttcgc cttgatgttg acgatgcaga aggtcgtgac
    16261 cgtgccgcgc gggccgacct cgacctgttc cccggtggcg accccgcagg tggggcaggc
    16321 gccacggggc gggacgtaga tcttgcggca ggacgggcag cgctcgccga cgatcctgcg
    16381 ctcggcgagc gcggccaggt ggtcgctctg ggcgcgaccg ggcgcgtagg tgtagtcgag
    16441 cctcgccggg gcgacgatgc cggtcacggc ttctgccgcg ggcccggccg cggtgcgggg
    16501 gaaactgccg ttgtgggcgc gcggcaaagg agcgggctcg ctcccgtacg gttcgaagca
    16561 ggcgatgtcg gtgatcgccc cggtgcgctc ggcggcccag cggacgcgta cccgcatccc
    16621 ggtgcgcacc gcgtcggggc cgggggcgtc gaggacgtgg aggagggcgg tgtccgcgcc
    16681 gtcgagccgt acgagcaccc aggcgaacgg gcgcgcgagc ggctgctggg agcgcggagc
    16741 cgggttccac gcccaggtgg tgacggtacc ggtggcgtgg acctcgacga gttcgcggag
    16801 ctcctctgcg gtgacggggt cgtactcgac gggcggtacg agcaccctgc cgtcgccggt
    16861 gcgcacaccg agcacggtcc gctcccgcag accggtcagg aaggcgctct gcacggggcc
    16921 gagggagcgg gtgaagggga actcgacgac cagcggggcg cgcagcactt ctggcatggg
    16981 gctctccgtg ggttgtcagg cgcgccggta gacggggtcg cgcttctcgg cgaaggcgcg
    17041 ggcgccttcc ttcgcgtcag cggtgtcgaa gacgggccac ccgcgcttca actcggcggc
    17101 gagcccgtcg gtctcggtca tctccgccgt ctcgtacacc gacgccttga ccgcctcgac
    17161 ggcgagcggg ccgcagccgt tgatgcgttc cgcgacgtcg agtgcggcgt cgagtgcggt
    17221 gccgtcgggg acgacgcggc cgacgaggcc gatgcgttcg gcctcggccg cggtgtaggg
    17281 gcgcccggtg agcagcatct ccagggcgtg ggtacgcgcg atctgccgcg gcaggcgtac
    17341 ggtcgagccg ccgatcggga agaggccgcg gcgtacctcg aagagtccga aggtggcgct
    17401 ctcgccggcg accctgatgt cggtgccctg gaggatctcg gtcccgccgg cgacgcagta
    17461 cccctcgacg gcggcgacga ccggctttct ggggcggtgg tggcggagca tggccttcca
    17521 gtgcaggtcg gggtcggcct tcatccggtc ccggtaccgc tcgcctgcca tgccggcgcc
    17581 cgcgagcgcc ttgagatcca tgccggcgca gaaggagccg cccgctccgg tgaggacgac
    17641 ggagcggacg gtgtcgtcgg cgtcggccgc gagccaggcg tcgtacagac cgaccagcat
    17701 cgcgatcgag agggcgttct tggcctccgg cctgttcagc gtgacgatca gggtggcgcc
    17761 ctggcgtgcc acagtgaggt gttcggtgcc cgtgcggtgg tcgctgcgat ggtccatggg
    17821 gaacctcccg atcccagacc tggaacaggt tgcagtagcc gggcgagcag ttcaatagtt
    17881 ttctgacagt cagtcagatt tccttgccgc gggcccttcc cagttgcggc gaccggcgct
    17941 ctaatgaccg ccaggttcgc cggggtcagg aggagcggtg gagtacaacc ttgccgacct
    18001 gttcgaatcc gtggtcgacg tcgtgcccga ccgcgaggca ctcgtgtaca tcgaccatcc
    18061 cggcaccggc gcgcagcgcc ggctccgcta cgcggagctc gacgcggcgg ccaaccggat
    18121 cgcgcaccat ctgctcgggg caggcatcgg ccccggcgag cacctggggc tgcacctcta
    18181 caacggaatc gagtatctgc agaccgtgct gggttgtctc aaggcccgga tcgtgccggt
    18241 gaacgtcaac taccggtacg tggaggacga actggtccac ctctaccgcg acgccgacct
    18301 cgccgcactc gtcttcgacg ccgagttcac cgagcgggtc gcggcggtgc tgccccgcac
    18361 cgagaggctg cggcacctgg tacgcgtcgg tacaccgccc gagggggtgc tgcgcctcga
    18421 cgcggtggac ttcgccgacg ccgaggcggc cggctcgccg cggcggggct tcgcgccgcg
    18481 ctcggccgac gaccggttca tcatctacac cggaggcacc acgggcatgc ccaagggagt
    18541 gatgtggcgt caggaggacc tgttcttcgc cggactcggc ggcggtgcgc cgacgggcga
    18601 gccggtctcc cggccggatg agctggccga acgggtggcc gccggcggcg acgggatcac
    18661 cttcttcccc actcccccgc tgatgcacgg gacatccacg ctcacggcgt tcatcggctt
    18721 caacttcggc cagcgggtcg tgctccaccg caagttcgtc ccgcacgagg tgctgcgcac
    18781 catcgagcgg gagaaggtca ccagtgtctc gctcgtcggc gacgcgatgc tgcggcctct
    18841 gatcgacgcg ctcaaggggc cgctgaaagg ctgtgacctg tcggccctgt tcagcgtctc
    18901 cagttcaggg gcgatcatgt cggacgtggt acgaaaggag ttcggcgccc tggctcccgg
    18961 cgtcctgctg ctgaacaact tcggctcctc cgagtccggt ttcaacggca ccgcgaccga
    19021 cgactccggc ccggccaggg gcttccggct gcgggtcaac gcccgtacca ccgtggtcga
    19081 cccggcgacc tacgaaccgg tgaaaccggg caggaccggc cgggtcgcgc agcgcggaca
    19141 cgtaccgctc ggttactaca aggacccggc gaagtccgcg gagacgttct tcgaacggga
    19201 cggcgaacgg tgggtgctgc tcggcgacat ggcgaccgtc gacgaggacg gcattgtcac
    19261 ggtcctcggc cggggctcgc agtgcatcaa caccggcggc gagaaggtct acccggagga
    19321 ggtcgagcag gcgctcaagg cgcatccgga tgtgtacgac gcactggtgg cgggcgtacc
    19381 ggaccgcacc tggggcaacc aggtggcggc cgtcgtccag ctgcgcaagg gggcccctgc
    19441 gccgagcctg gacgcgatcc ggtcgcactg ccgcagccgg ctggcgggct acaagatccc
    19501 acggcagttg gtggtcgccg aggagatccg gcgctcgccg agcggcaagg cggactaccg
    19561 ctgggcccgg gccgtcgcct cggaggcggc gggcgccgca ggcctgacgg agaaccgctg
    19621 ctgagcgggc ggccccggtg ctatcagtct ccgtcgccgg gcaggatccg ttcgccgttg
    19681 aagacaccga gccgctcctg gtacagctcg agtggtacgc cgttggggtc atggatgtag
    19741 aggctgtcct cgaccccccg gtcggggccg acgtactcca cgcccgccgc gtccagcgcc
    19801 tcgcgggcgg caccgaaccg gctcgcgtcg accgacaggg ccatgtgctg cacgccgccg
    19861 atcgtctccg tcgccgccgg atggtcgtgg ccggggaagt cgaagaaccc gagcaggttg
    19921 ccgttgccga tgtcgaagaa gaagtgggtg gaaccgcggt agtcccggtt ctccacgatc
    19981 tccaccaacg ggaacccgag gaactcctgg tagaagcgga tggtctcctc cacgtcgcgg
    20041 cagatgaagg ccacatggtg gataccgcgg gtggtggtcg ccggccggtc atcgggtgcg
    20101 cgcagatact ggcgcctgag ctcctcacgg cgggcgcgca gggcttcgag ttcggctccc
    20161 tctggctggg gcatcgcggc tccttcacga acagtgtgta cgggtttcaa caactgcccc
    20221 gcaacttacg cgacggacgg cacacaccgc tgcgacctgc cccgcgacac ggcggcacgg
    20281 cgcccaccgg tcacggcgcg gacagcagcg ccgcgaccgg aacgacggga tccttgtccg
    20341 gcacctgttc ggtgaggcgg gcgaagacgc ggtgccatgc gtcggcgtcg tcgccgagcc
    20401 ggtcgcgcac cagatcggcg accgccgcca aggccgtgtg cacctcggcg ggcgcgtcgg
    20461 aacggcgctg ggcaccgttg agacagctca gcacgactgc agccggcgcg gcttcgtgta
    20521 tcaggtcccg gccggtcagc tgtcctgtcg tcagcagatg gtcgatcagg gtgtccgtcg
    20581 actcgcgtga ccccacgggg gccatgccgt gccgcactcg ggccacggtc agctctcgtc
    20641 ccagtggcac ggtgcgcagg gacggcacag gcaggtggac ggcgttccgc agccggaagt
    20701 cgtgcggggc atcaggacgc cggacgatct ggtcccattc ggggatcggc tccgcacggt
    20761 gctcggcctc gagcgcgtcc cagtcgagag cgcccgggcg gttcgtgagg attgcccggg
    20821 tgtcccagtg tcccttcacc cggcgcagcc gtttcaccag ccgttccgcc gacaactccc
    20881 gccgggcgcg cgcagccagg ggcgcggccg ggtccgcggc tgcgagcgcc ttctgacaca
    20941 gccgggtcgc ggccgccccc agcagtccgc cctccgcgag cgccgccagc cgctccggtc
    21001 cgccgtgacg gagcaggttc aggcagccca ccagttgctg tgccagatcg aggcgcctgc
    21061 ccgacctggc gaacacgagc tcgacgaggt ccggttccgc ggactccagc cacagggggc
    21121 cgcccggcgg gacggcgagc gggtcggcgc gcagctcggc gacgaggcgt ggtgccaggt
    21181 cgcccggccg ggcgacgata cggcgcaaga gccccacgtc gtgggtggtc cgcagtacgg
    21241 ccaggtcgac atcggggtcg gcgaggtcga gcagtcgggc ggtggcctcg tcgtcgagcc
    21301 atcgtgactg ctcggagagg acccgcagcg ccggccggtc gcccagttgg agcaggtgct
    21361 cgaacggtac gcggggcgtc ggcttcgacc gcaggaggaa cgctgcgagc atccagggcc
    21421 cgtccgggcc gaagcgaggc agcaccgcgg caagaaccgg gggggcggcg gcgcacagca
    21481 aggtgcccag gggccactgc cacagatggt tgccgcgggc gagcagggag agggcggcct
    21541 ccggggtggg cggtgcgacg gtcgccgaga aggaggaggt gccgactccc gcgcacagct
    21601 ctctcaacat gtccgcgtcg tgcgagccgt cctggcgtga acggtccagc agctcgggcc
    21661 acgtgtcggc ggccccctcc gtgcggtggt cgctttggcc ggcggccgcg ccgcgtgcgg
    21721 ccgcggcgag ccgtagccag gcgtccgcgt ccgttccgag ttccctttcg aggaacgcgg
    21781 cgagcgcccg cctccaggcc acggggaagt gcaggtcctc ccagccgtac ggcaggcgca
    21841 gcagccaggc tgccggtagg tgacgcagca ggtcgtctgc ctgcacgatg ccgttgcggt
    21901 acgcccgttc ggcgacacgg gcgacggcct cggtgttcgg ttcctcctcg atccaggaca
    21961 ggacgtcctg gcgggtcggc gctgcgcagc gatgggccgc gtactccagc ccctggtcca
    22021 tgcaggcctt ccacagccag tccgggtgct gccatccggg cgcgtccgcc ccggcgtggg
    22081 ccgtcagatg ccgcaggacc gccgggtcct gcggcagcgg ggcggtgccg gacggtgcga
    22141 gcgacagcag gaggtcgacc gcgccgagtg cggagcgccc gcagggcccg acgggcttc
//
