LOCUS       NZ_BMWB01000006        20209 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence06, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000006
VERSION     NZ_BMWB01000006.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 280952)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 20209
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20209
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20209
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20209
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[9168:10209](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9169..10209)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(112..2391)
                     /locus_tag="IE198_RS12050"
                     /old_locus_tag="GCM10010381_24370"
     CDS             complement(112..2391)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846480.1"
                     /locus_tag="IE198_RS12050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24370"
                     /product="MMPL family transporter"
                     /protein_id="WP_189885654.1"
                     /transl_table=11
                     /translation="MLSKALLRLGASAARHPWRVIAAWLIAATLAVLAAVAFGGRTADS
                     MTAPGLDSRRAAELIERAGTGQEGMTAQVVVTPLDDGATFFDDDDDDGARAALTRLRAE
                     VKRLPHVLGTSDPAGALDAGGDTAVRGGLVSADGRIAVVRVQYPDQSRLSAEDLDALVD
                     LGDRLRAELPLRIEMGGNLFYVFSDPDGGASELIGLLAAAAILFLAFGSLVAAALPIGM
                     AVFGLTVGVATMTVLAGVTEVPTFAPVLGSMVGLGVGIDYALFVLARHREYLACGLDPQ
                     AAAGRAVATAGRPVVFAGGTVVVSILGLAVANVPFMTVGGVAVSIVVLTMVLASVTLLP
                     AFLGAAGPRLARAGRIGRALQTRKLGRLARRRDPAAGAAHAAGWRRWIGHVSQHPVPYA
                     VGAAGLLLTATLPVLGLRVGLPDDGSLPHSRTERRAYDLVAEGFGPGTNGPLVIAADHT
                     GDPGVLDRLVATVAADPGIASVAPTHIDRATGIATLVVFPTTSPQDKATADTIARLRTD
                     VLPTAIGHGPARAHVGGAAASLSDVGQRTSQRLPVFVAAVLAMSFLLLMLVFRSILVPL
                     KAVLLNLLSIGAAYGIMVAVFQWGWGGALIGLEATVPIVSFIPMFLFAILFGLSMDYEV
                     FLLSRVREEYLRTGDNGTAIVEGVSRTARIITSAALIMVAVFLSFAVAEDPSTKMFGLG
                     LATAIFIDATVVRMVLVPATMTLLGRTNWWLPKWLDWMLPRGPVGTDETDAKSTGEAPR
                     PRLVDR"
     gene            2567..3739
                     /locus_tag="IE198_RS12055"
                     /old_locus_tag="GCM10010381_24380"
     CDS             2567..3739
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031367.1"
                     /locus_tag="IE198_RS12055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24380"
                     /product="sensor histidine kinase"
                     /protein_id="WP_189885656.1"
                     /transl_table=11
                     /translation="MLRDDLRTLWTEPRPPDAPARVRRDWALLAAGLAGVALEATLREN
                     VVWRPVAVVFAVWLCLLPLWRRTRPLAMVTLAFGSVILLPVASLVAAPREPVGLYTGGV
                     VLVLVYALPRWGSGREIVLGGAVILAAGALCVVTDETPVVEKVVGFVFLLLPGVVGAAV
                     RFRVTARERQLEQVRSREREQLARELHDTVAHHVSAMVIIAQAGRVLAGTDPSAAVEAL
                     EGVEEEGARTLEEMRAMVAALRDRGVGAELAPPAGVADLERLVRTPGDRLRVDLGLDGE
                     LDALPAAVDAAVYRIVQESVTNALRHAVDATELVVRVAAERHTVRVSVRDNGRRTGRGR
                     DGYGLTGLRERATLLGGTLRAGPGTDRGWHVEAELPRARSESGVHSRPRR"
     gene            3714..4376
                     /locus_tag="IE198_RS12060"
                     /old_locus_tag="GCM10010381_24390"
     CDS             3714..4376
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846478.1"
                     /locus_tag="IE198_RS12060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24390"
                     /product="response regulator transcription factor"
                     /protein_id="WP_189885658.1"
                     /transl_table=11
                     /translation="MSIRVLVADDQTIIRTGLRIMLNAQPGIEVVGEAADGREAVRLAR
                     ELRPDVCLFDIRMPVLDGLEATRLVAGPGVADPLAVVVITTFDLDEYVYGSLRAGARGF
                     LLKDTGPDLLAQAVRSASDGEALIAPSVTVRLLQAFADLPAGRPVAQPVSPVTAREEQV
                     LLAVARGLTNTEIADALHISLSTVKTHLASLMAKLGARNRVEIAMWAYETRRVLPGT"
     gene            complement(4714..7518)
                     /locus_tag="IE198_RS12065"
                     /old_locus_tag="GCM10010381_24400"
     CDS             complement(4714..7518)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474903.1"
                     /locus_tag="IE198_RS12065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24400"
                     /product="AAA family ATPase"
                     /protein_id="WP_373299830.1"
                     /transl_table=11
                     /translation="MCGASANGSGARRGGVLVFAAPAGLGKTTLLAEARRHATERGCTV
                     LSARGGEQEKQVPFHVVRQLIQPTVAAMSEGEHREILGHWYGIVAPAIGLTAPQDGAAP
                     DPQGVRDGLDWVVTRLSVRSPPVVLILDDAHWADAESLAWLTAFATRAQELGMLIVVAC
                     RPDELPPDATVLHTLASRHGARPHRLEPLTPSAVARIVRNALGDGADDLFCRECWAITG
                     GNPFEVVELTAKARDRGLRPLRDNIPHLRDLASAVKGSGLIERLEQLGPSTVRLAWAAA
                     VLGTGISTRIAASVAALGDAQINEAIDQLHAARILTVLTTVKREEVVEFFHPLIATAVY
                     RSIPPGVRVAMHGMAARTVIDAGLGAGAAARHMLEMHPEGDPWVVQQLRQAARENFSAG
                     APDAARRYLARALREPPVPEDRAQVLFELGSASLLHEPTTTVNHLRAALEEPKIEQGLR
                     EAVVYRLAQALAHTGKLVQATELLAEEARRTSSARTKLRMQAEQFRWNAVRVDEQDSPA
                     RSRLLAQFAKRLTGRSLAERHILGLRGWDCVMRGEPSARALQYAERALDGGLRWTDQDF
                     GFEVPAVIALTLMYCDQPGRAEELFSDAITEFEARGWRGAHLSFAYTLLGYVRYRRGRL
                     TEAEDFVRQGLEIADRVGRGIPAQWQAVGTLIETQLAHGDLAEAQRVAESYDFGKDFPN
                     SVIYPDPQAVWGKLLLARGMNDEAERQLAEAGQRLDSRGTRNPAWSPWQLDLALAQAKH
                     QPEKARATAQDAVARARAFGTAGVIGHALRVQAATTDPAEAVVLLQEAVEHLETSPAAY
                     ELAHALIDHGAALHALGNLERAAHQLYSGMEAATGCGADGLATRARTELAAAGLRPRRR
                     QSREQDTLSEAESVAARHAALGLDNAAIAAEFGIGEDAVSKLLSAVFTKLGTDRAGLRR
                     ALGM"
     misc_feature    7550..7565
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.67"
                     /tool="antismash"
     misc_feature    7680..7694
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.31"
                     /tool="antismash"
     gene            complement(7802..9145)
                     /locus_tag="IE198_RS12070"
                     /old_locus_tag="GCM10010381_24410"
     CDS             complement(7802..9145)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742345.1"
                     /locus_tag="IE198_RS12070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24410"
                     /product="cytochrome P450"
                     /protein_id="WP_229833857.1"
                     /sec_met_domain="p450 (E-value: 2.3e-83, bitscore: 274.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHVNPSGEAAVAPGGLPVLGHALQLWRRPIAFLESLRTHGDVVR
                     VDVATWPVHVLTSPELIQTVLVGDAKNFGRGRVFDRLRPLFGNGLPLADGEFHRRQRRL
                     LQPAFHRNHITAYAEMMCRLADEMSTSWTAGQEISVTTEMRRFALSSVAAMIFSGDLGR
                     SAVEEVHRSFPVLVEGILRRAIMPKALDRFPITMNRRFDTAAARLRRIIDEVIVRYGTE
                     GSGRDDFLSLLLSTVDAETGETMSDEQVRDEVISIFFAATETSATVLSWIFHELARHPE
                     VEKRLHDEVDEVIGTRPVRPSDLAGLTYTNNVFQEALRLHSPLLFTRRALVPVKLGGVS
                     IPAGAELGYSPYALHRDPALYHEPGKFDPDRWSTDSADRPRPHRFIPFGAGQHKCIGDS
                     FAASEIVIAVATVASRWRLVHAPGTTVRNVPGGIPQPDALAMIPLARH"
     gene            complement(9169..10209)
                     /locus_tag="IE198_RS12075"
                     /old_locus_tag="GCM10010381_24420"
     CDS             complement(9169..10209)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742346.1"
                     /locus_tag="IE198_RS12075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24420"
                     /product="terpene synthase family protein"
                     /protein_id="WP_189885663.1"
                     /sec_met_domain="T1TS (E-value: 6.7e-63, bitscore: 207.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLDSFTIPDFYLPFESAKHPQSGRANSEATSWALRHGLITDAA
                     EQFAGIGFGHLSGRVCQEAPYRHVVLLAEWMAWSFVLDDQHDHLIRAERLEAWPPLTDA
                     ITGYLATGQVDSAPQLRENPLVVGFIDLCDRILSEMPTTIRERYRAHIPLMLRSLDQEA
                     VNRNAAQQPTIEDYVRMRRHSSQLLPMMDMVEAGLGVEVPPEVYDSSAFQDLMSSALDV
                     ISWGNDVFSLRKEFSCGDNNNLVSLLAWWNECSLPEAVLAVQERTRSRVEDFLTAAQGL
                     PDVLDTLGVTDPSARAGVARCVKSYQDWMIGADLWQRYECTRYNDERWVAGLESTYTRP
                     DLVPGI"
     misc_feature    complement(10399..10414)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.55"
                     /tool="antismash"
     misc_feature    10946..10960
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            complement(10958..13483)
                     /locus_tag="IE198_RS12080"
                     /old_locus_tag="GCM10010381_24440"
     CDS             complement(10958..13483)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525623.1"
                     /locus_tag="IE198_RS12080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24440"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_229833858.1"
                     /transl_table=11
                     /translation="MDGMTVGGTAEREDLLAAAVVEAVERTGAYGGSVFLRSSDRRSIV
                     LAATCGVPPSLLGGWRLIPVNGPIPVAEAYSFGRTVHLADAEETMRRYPQLAVALPYAF
                     GSCSVPVGTGGETFGSLAIVRAATPGSEGLSKARRRHLRSVASRLGDSLAALRARTGDP
                     VECDGETVPVEIPAPSGAAVQVGFFQWDLGTGTFLVDDELCAICGLDPHAFDQRADTLA
                     SRLHPGDLTAFRAFAREAAMDGRTTSRRVRLSDPGHGGEGYRTVELWGRVPNADDPRAG
                     THLVGAVVDARVGHMAVAAVERLRDGVFSLAPDGRVTYANHSALRLLGASGDELLGHYL
                     WDVVTWLSDPDVEYRHRSAMISQSPASFLACRPPDRWLSFSLHPEADGVTGRVVPVGRP
                     PPDSTTSASSASPATAPSRLGVMYHVLQLGSALTEAVTAREVCEVVSDQLLPAFGGQQL
                     AIYVVRDGTMHLLFHTGHHEDFLDWLEGVPLHARLPGTETLTSGAPLFIESQKDLSRGY
                     PGIPTGEVSSWAYLPLIASSRPVGTCILGFDDIHQFTERDRGVLTALAGLIAQALERAR
                     LYDSEFALARGLQKALLPHRLPRVPGIRSVVRYLPGTSGMDIGGDWYDIIPTESGVCLV
                     IGDVEGHSIAAAATMAQLRSAVRAFAAVGPMPGDVLTGVNRTLIDLGPGLLASCCCIYF
                     DPQGPQDHHAYAVTAGHPPPLLRRPDGTTDVLDLEVGPILGVERASAYPETRIALPPGS
                     VLALYTDGLVEEPGTDIDVGIDRLRASLAHARADSLDELADRLLHNARSFSYRADDIAL
                     LLTEFRPPFPGGHQGDDRDDFAAGRSAAR"
     gene            complement(13933..14406)
                     /locus_tag="IE198_RS12085"
                     /old_locus_tag="GCM10010381_24450"
     CDS             complement(13933..14406)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483477.1"
                     /locus_tag="IE198_RS12085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24450"
                     /product="lamin tail domain-containing protein"
                     /protein_id="WP_189885664.1"
                     /transl_table=11
                     /translation="MSASSTARRVMATVLAAGAVVTVVALPASAHDDDRDRRYRQHPRV
                     EISAVHADSPRRETRSNRSLNAEWVEITNTSRRSVDLDGWTLRDLDGNRYCFDDYILAG
                     RSTVRVHTGMGRDTRTDLYQDRRTSVWDSRYDEAVLRDHRGNTVDIESWNRGR"
     gene            complement(14975..15616)
                     /locus_tag="IE198_RS12090"
                     /old_locus_tag="GCM10010381_24460"
     CDS             complement(14975..15616)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240779.1"
                     /locus_tag="IE198_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24460"
                     /product="lactate utilization protein C"
                     /protein_id="WP_189885666.1"
                     /transl_table=11
                     /translation="MTSRSSSRERILAKVRSALADAPDAPEVTRDYLASHTSDDPAALL
                     DLLHENLTDYRAVVHRSTEHHLPSLIGRLLADQGARTVVVPPGLPSGWLASTRVEQCFD
                     AGPLVPAELDSIDAVITGCALAVAETGTIVLDAGPGQGRRALTLVPDLHICVVNASDQV
                     VASVSQALPRLDATRPLTWISGPSATSDIELDRVEGVHGPRRLEVVLVID"
     gene            complement(15613..17037)
                     /locus_tag="IE198_RS12095"
                     /old_locus_tag="GCM10010381_24470"
     CDS             complement(15613..17037)
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0019516 - lactate oxidation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890741.1"
                     /locus_tag="IE198_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24470"
                     /product="LutB/LldF family L-lactate oxidation iron-sulfur
                     protein"
                     /protein_id="WP_189885669.1"
                     /transl_table=11
                     /translation="MSGTFMGMPAFPKAARDAVRDTTLRGNLRHATRTIRAKRAAAVAE
                     LEDWPQLREAGKQIKDHTLRHLDRYLEQVEQAVTAAGGTVHWAADADEANRIVADLVKA
                     TGETEVVKVKSMATQEIGLNTALEAAGIRAYETDLAELIVQLGDDLPSHILVPAIHRNR
                     GEIRDIFRDNMASWGRPAPEDLTDRPADLAEAARLHLREKFLRAKVGISGANFMIAETG
                     TLVVVESEGNGRMCLTLPETLISVVGIEKIIPTWRDLEVFLQLLPRSSTAERMNPYTTM
                     WTGTTDGDGPRTFHLVLLDNGRTDTLADEVGRQALRCIRCSACLNVCPVYERAGGHAYG
                     SPYPGPIGAILTPQLRGIASEVDASLPYASSLCGACYEVCPVAIDIPEVLVHLREKVAD
                     QGGRGHRLEKAAIKAATWLLDHPAALTAGERLASRTRKLHPERLPGPGTRQWTNSRDLP
                     DLPAEPFRDWWKKNHA"
     gene            complement(17034..17789)
                     /locus_tag="IE198_RS12100"
                     /old_locus_tag="GCM10010381_24480"
     CDS             complement(17034..17789)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389338.1"
                     /locus_tag="IE198_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_24480"
                     /product="(Fe-S)-binding protein"
                     /protein_id="WP_189885671.1"
                     /transl_table=11
                     /translation="MRVALFATCVNDALYPSTAIATVRLLERLGADVDFPAAQTCCGQP
                     QFNTGYRRETEPLVRRTARAFADYDHVVTPSGSCVAMIRDNYPRIGARAKAEGRGEELA
                     EAAASLVPHVYELTEFLVDVLGVTDTGAYFPHTVTYHPSCHGLRMLGLGDRPRRLLQAV
                     RGLELIELPGAEECCGFGGTFAVKNPDVSEAMGADKLRNALSTGAGVLCGADNSCLMHI
                     GGMLRRQDAPQRTLHLAEILASTEEEPLV"
     misc_feature    17761..17776
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.31"
                     /tool="antismash"
     gene            complement(17890..18147)
                     /locus_tag="IE198_RS12105"
     CDS             complement(17890..18147)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189885673.1"
                     /transl_table=11
                     /translation="MHNAPPAGDAEPSFGGRRTDDAGAPASEELRAVVRDRLDDVDDLV
                     SRYAAQVSAFDDHQGSAGRGPAREGAHASSCCCGSSAACT"
     misc_feature    18149..18165
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(18423..18435)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(19093..19103)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    19671..19687
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.68"
                     /tool="antismash"
     misc_feature    19798..19815
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     misc_feature    20133..20147
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.96"
                     /tool="antismash"
ORIGIN
        1 acggcgccgt caccctggca gccatccggt tatggctcag gacatgatcc gccggacaga
       61 acctaggtga cgcgctgagg tgccggacgc caagggcggg cagaagttga gtcaacggtc
      121 aaccagccgt ggacgcgggg cctcacccgt ggatttcgcg tcggtttcgt cggtgccgac
      181 cgggccgcgg ggaagcatcc agtctagcca cttcggcagc caccagttgg tccggccgag
      241 gagtgtcatg gtcgccggta ccagcaccat gcgtacgacc gtggcgtcga tgaagatcgc
      301 ggtggccagg ccgagcccga acattttggt ggaggggtcc tcggcgacgg cgaaggacag
      361 gaagaccgcc accatgatga gggcggccga ggtgatgatc cgggcggtgc gcgagacgcc
      421 ctcaacgatc gccgtgccgt tgtcgccggt gcgcaggtac tcctcgcgta cgcgggagag
      481 gaggaacacc tcgtagtcca tcgacaggcc gaacaggatg gcgaagagga acatcgggat
      541 gaacgacacg atcggaaccg tcgcttccag cccgatgagt gcgcctcccc agccccactg
      601 gaagaccgcg accatgatgc cgtaggccgc gccgatgctc agcagattca gcagtaccgc
      661 cttgagcggt acgagtatcg agcggaagac cagcatcagc agcaggaacg acatcgccag
      721 cacggcggcg acgaacaccg gcaggcgttg gctggtgcgt tggcccacat cggacaggct
      781 cgcggcggcg ccgccgacgt gggccctggc cgggccgtgc ccgatcgccg tgggcagcac
      841 gtcggtgcgc agccgggcga tggtgtcggc cgtggccttg tcctgagggc tggtggtcgg
      901 gaacaccacg agggtcgcga tgccggtggc ccgatcgatg tgcgtcggcg cgacggatgc
      961 gatgcccgga tccgccgcga ccgttgcgac gagtcggtcc agcactcccg gatcaccggt
     1021 gtggtccgcg gcgatgacga ggggaccgtt ggtgcccggg ccgaacccct cggcgacgag
     1081 gtcgtaggcc cggcgctcgg tacggctgtg gggcagtgag ccgtcgtcgg gcaggccgac
     1141 gcgcaggccg agcacgggca gcgtcgcggt cagcagcagc cccgccgcgc cgaccgcgta
     1201 cggcaccggg tgctggctga cgtgcccgat ccagcgacgc cacccggcgg cgtgggcggc
     1261 gcctgccgcc gggtcccgcc gccgtgcgag tcggcccagc ttcctggtct gcagagcccg
     1321 gccgatccgg ccggcccggg ccaggcgcgg gcccgccgcg ccgaggaagg ccggcagcag
     1381 cgttaccgac gcgagcacca tcgtcaggac gacgatcgag acggcaaccc cgcccaccgt
     1441 catgaacggc acgttcgcga ccgccaggcc gaggatcgac acgacgacgg tgccgccggc
     1501 gaagaccacc ggccgccccg ccgttgccac cgctcgtccg gccgccgcct gcggatcgag
     1561 cccgcacgcg aggtactccc ggtgcctggc gagcacgaac agcgcgtagt cgatgcccac
     1621 tccgagcccg accatgctgc ccaggaccgg tgcgaaggtg gggacctctg tcacccccgc
     1681 cagtaccgtc atcgtggcga ccccgacggt cagcccgaag accgccatgc cgatcggcag
     1741 cgcggcggcg acgagcgaac cgaacgccag gaacaggatc gcggccgcgg cgaggaggcc
     1801 gatcagctcg ctcgcgccgc cgtcggggtc ggagaagacg tagaagaggt tcccgcccat
     1861 ctcgatgcgc agcggcagct cggcgcgcag ccggtcgccg agatcgacga gggcgtcgag
     1921 gtcttcggcc gacagccggc tctggtcggg gtactgcacc cggacgaccg cgatccgccc
     1981 gtcggccgaa acgaggccgc cgcgcacggc ggtgtccccg cccgcgtcga gcgcccccgc
     2041 cgggtcgctc gtgccgagca cgtgcggcag ccgcttcacc tcggcccgca gccgcgtgag
     2101 agcggcgcgc gcgccgtcgt cgtcgtcgtc gtcgaagaac gtcgcaccgt cgtcgagggg
     2161 ggtgacgacc acttgggcgg tcatcccctc ctggccggtg cctgcccgct cgatcagttc
     2221 cgcggcccgt cgggagtcca gtcccggagc ggtcatcgag tccgcggtcc gcccgccgaa
     2281 ggcgacggcg gcgaggacgg cgagcgtggc ggcgatcagc catgccgcga tcacccgcca
     2341 gggatggcgg gcggcgcttg cgcccaggcg caacagggct ttcgagagca tcgggtcctc
     2401 caaccacctc gtcggccgtc cttgtacggc cgccgatgcc gaggctcgtc gccacggcgc
     2461 tccgcggcat cggcccgcgg gccgcggatc cctcggcccc ggggcggagt gacgacccgt
     2521 cctttcggcc gatgcgcggc acgccgcggt ccctaggctg agaaccgtgc tccgagacga
     2581 cctgcgaacc ctgtggaccg aaccccggcc gcccgacgcg cccgcccggg tgcggcggga
     2641 ctgggcgctg ctcgccgcgg gccttgccgg tgtggcgctg gaggccaccc tgcgcgagaa
     2701 cgtcgtgtgg cggccggtgg cggtggtgtt cgccgtatgg ctgtgcctgc tgcccctgtg
     2761 gcgccggacc cgcccgctgg cgatggtgac gctggcgttc ggctcggtga tcctgcttcc
     2821 ggtggcctcg ctcgtcgccg caccgcgcga gcccgtcggc ctgtacaccg gcggggtcgt
     2881 gctcgtgctg gtgtacgcgc tgccccggtg gggatcggga cgcgagatcg tgctgggcgg
     2941 cgcggtgatc ctcgcggccg gcgcgctgtg tgtcgtcacg gacgagaccc cggtcgtcga
     3001 aaaggtcgtg ggcttcgtct tcctgctgct gcccggcgtg gtcggggctg ccgtgcggtt
     3061 ccgggtgacc gctcgcgagc ggcagttgga gcaggtgcgc tcccgcgagc gcgagcagct
     3121 cgcccgggaa ctgcacgaca cggtggccca ccacgtgtcg gccatggtga tcatcgccca
     3181 ggcgggccgg gtgctcgcgg gcaccgaccc gtccgccgcc gtcgaggcgc tggagggggt
     3241 cgaggaggaa ggggcgcgca cgctggagga aatgcgcgcc atggtcgccg cgctgcgcga
     3301 ccgcggggtc ggcgccgagc tggcgccccc tgccggagtc gcggatctgg agcgcctggt
     3361 gcgcaccccg ggtgatcgcc tcagggtcga cctggggctc gacggcgaac tggacgcgct
     3421 gcccgcggcc gtggacgcgg ccgtctaccg gatcgtgcag gagtcggtga ccaacgcgct
     3481 gcgccatgcg gtcgacgcga ccgagctcgt cgttcgggtc gccgcggaac ggcacacggt
     3541 acgggtgagc gtgcgcgaca acggccggcg caccggccgg ggtcgcgacg gatacggact
     3601 taccggactg cgcgagcgcg cgaccctgct cggcggcaca ctacgagccg gcccgggtac
     3661 cgaccggggc tggcatgtcg aagccgaact gccgagagcg aggagcgaga gcggtgtcca
     3721 ttcgcgtcct cgtcgctgac gaccagacga tcatccgcac cgggttgcgg atcatgctga
     3781 acgcccagcc cggcatcgag gtggtcggcg aggccgccga cgggcgggaa gcggtacgtc
     3841 tggcccgcga actacgcccc gatgtctgcc tgttcgacat ccgcatgccc gtactcgacg
     3901 ggctcgaggc cacccggctg gtcgccggcc cgggcgtcgc cgacccgctg gccgtggtcg
     3961 tcatcaccac gttcgacctc gacgagtacg tctacggctc actgcgtgcc ggcgcccgcg
     4021 gattcctcct caaggacacg ggaccggacc ttctggcgca ggccgtacgg tcggcgtccg
     4081 acggtgaggc gctcatcgcg cccagcgtca ccgtccgtct gctccaggca ttcgcggacc
     4141 tgcccgccgg ccggcccgtg gcccagccgg tctcccccgt caccgcccgc gaggagcagg
     4201 tgctcctcgc cgtcgctcgc gggctgacca acaccgagat cgccgatgca ctgcacatca
     4261 gcctcagcac ggtgaagacg catctggcca gcctgatggc caaactcggc gcccgtaacc
     4321 gggtcgagat cgcgatgtgg gcctacgaaa cgcgccgtgt cctccccgga acctgagccg
     4381 ggtgccgggc catgtcccgt gagtccccgc ccggacatca gtgcacggtc ggctcacgtc
     4441 ggctccacgt gcctcacccg cccctgagcg tgacgtacca ggaggccgga actgggacgg
     4501 tgagacaccc gatacgacaa gactcccgac agctacctcg ccagtctcca cctgcacgcc
     4561 tcgatgatct ggatcaaaga cctcaccagg accacccgat gatcacgact cgatacgcgg
     4621 cctagtacgg gcgcccggcg cagggcgcac ccgcgtcggg tccggccggc acctgtccgg
     4681 ccggacccgt gagccgtccc cggccccgcc cgatcacatg ccgagcgcgc ggcgcaggcc
     4741 cgctcggtcg gttcccagtt tggtgaagac ggcggacagc agtttcgaca cggcatcctc
     4801 tccgatgccg aactcggcgg cgatcgccgc gttgtcgagt ccgagcgcgg catgacgggc
     4861 tgccacgctc tccgcttcgg agagggtgtc ctgttccctg ctctggcggc gacgcgggcg
     4921 cagtccggcg gcggcgagct ctgtccgggc gcgggttgcg aggccgtcgg cgccgcagcc
     4981 ggtcgcggct tccatgccgg agtagagctg gtgggcggcg cgctccaggt tgccgagggc
     5041 gtgcagggcg gcgccgtggt cgatgagcgc gtgggcgagt tcgtacgcgg ccggcgacgt
     5101 ctcgaggtgc tcgacggctt cctggaggag gacgaccgcc tcggccgggt cggtggtcgc
     5161 cgcctggacg cgcagtgcgt gaccgatgac gccggcggtt ccgaacgcgc gggcgcgcgc
     5221 aacggcgtct tgtgcggtgg cacgggcctt ctcgggttga tgcttggcct gcgccagggc
     5281 gaggtcgagt tgccaggggc tccacgcggg gttgcgtgtg cctcggctgt cgaggcgctg
     5341 gccggcttca gcgagctgcc gctcggcctc gtcgttcatg ccgcgggcca ggaggagctt
     5401 gccccagacg gcttgggggt cggggtagat gaccgagttg gggaagtcct ttccgaagtc
     5461 gtaggactcg gcgacgcgct gggcctctgc aaggtctccg tgggcgagtt gggtctcgat
     5521 gagggtgccg accgcctgcc actgcgcggg gattccgcgc cccacccggt cggcgatctc
     5581 gagtccctgg cgtacgaagt cctctgcttc ggtaagccga ccgcgccggt agcggacgta
     5641 gccgagcagg gtgtaggcga aggacaggtg cgcgccgcgc catcctcgtg cttcgaactc
     5701 ggtgatggca tcgctgaaca gttcttcggc cctgcccggc tgatcgcagt acatgagggt
     5761 gagagcaatg acggccggca cctcgaaccc gaagtcctgg tcggtccatc tcagaccgcc
     5821 gtccagagct cgttccgcgt actgcagtgc cctggcagag ggttcaccgc gcatcacgca
     5881 gtcccagccg cgcagcccca ggatgtggcg ttcggccagg ctgcggccgg tgaggcgctt
     5941 ggcgaactgg gccagcagcc gggagcgggc cggtgagtcc tgctcgtcga cgcggaccgc
     6001 attccatctg aactgctcgg cctgcatacg cagtttggtg cgggcgctgg aggtgcggcg
     6061 ggcctcctcc gcgagaagtt cggtcgcctg taccaacttg ccggtgtggg cgagggcttg
     6121 ggcgagccgg tagacgaccg cttcccgtag accctgttcg atcttgggct cttccagtgc
     6181 ggcccgcagg tggttgacgg tcgtggtggg ttcatggaga agactggctg aaccgagttc
     6241 gaacagcact tgggcccggt cctcgggaac cggcggttca cgcagagcgc gggccagata
     6301 gcggcgggcg gcgtcggggg ctccggcgga aaagttctcg cgggcggcct ggcgcaactg
     6361 ctgcacgacc caggggtcgc cttccgggtg catctccagc atgtggcggg cggcggcccc
     6421 ggcgccgagg ccggcgtcga tcacggtcct cgccgccatg ccgtgcatgg cgacgcgtac
     6481 ccctggaggg atggaccggt acacggcggt ggcgatcagc gggtggaaga actccacgac
     6541 ctcctcgcgt ttcaccgtgg tcaggaccgt caggatgcgc gcggcgtgca gttggtcgat
     6601 ggcctcgttg atctgcgcgt cgccgagcgc ggcgacgctc gccgcaatcc ttgtggaaat
     6661 gccggtgccc agcaccgcgg cagcccatgc gagccggact gtggagggcc cgagctgttc
     6721 gagccgttcg atgagcccgc tgcccttgac ggctgaggcg agatcacgga gatggggaat
     6781 gttgtcccgc agtggcctca ggccacggtc gcgggccttc gcggtgagct cgacgacctc
     6841 gaacgggttc ccgccggtga tcgcccagca ttcccggcag aacaggtcgt cggcgccgtc
     6901 gccgagggcg ttgcgcacta tgcgcgccac cgcactcggt gtgaggggct ccagccggtg
     6961 cgggcgcgca ccgtggcgcg aggccagggt gtgcagcacg gtggcgtcgg gagggagctc
     7021 atccggcctg caggccacga cgatcagcat ccccagctcc tgggctcgtg tcgcgaaggc
     7081 ggtgagccac gcgagggatt ccgcgtctgc ccagtgcgcg tcgtcgagga tcagcacgac
     7141 gggcggggaa cgcaccgaca gtcgggtgac gacccagtcg agaccgtcgc gcactccctg
     7201 ggggtcgggt gcggcaccgt cctgcggggc ggtcagaccg atcgccggtg cgacgatgcc
     7261 gtaccagtgc cccaggatct cgcggtgctc gccctcgctc atggcggcga ccgtgggctg
     7321 gatgagctgg cgcaccacat ggaacggcac ctgcttctcc tgctcgccgc cgcgcgcgga
     7381 cagcaccgtg cagccgcgtt cggtggcgtg cctgcgggct tcggcgagca gggtcgtctt
     7441 gcccaggccg gctggtgctg cgaagacgag cacaccgccc cgccgcgcac ccgagccgtt
     7501 ggccgaggct ccgcacaact gacccaacgc aagctggatt gcgtggactt cggattcccg
     7561 ttcgagaatg ggctgatcag cccacccttg ctgctccacg acctgtgtca cctcttggcc
     7621 ccctcaagcg cgtgccgccg agtgtacggt cagaggggtg gggtgatact ccttacgacc
     7681 attttcaggg aattcggcca ctcattcgtg ggtggacctg tacccttcgc tgacgcagcc
     7741 gcaggcacgg attcgtgaga cgtccggaga tcgccgcgaa ggtgccaagg accgtattcc
     7801 gtcagtgtcg tgccagggga atcatggcca gcgcatccgg ctgagggata cctccgggaa
     7861 cattgcgcac agtggtaccc ggggcgtgga ccaaccgcca ccgggacgcc acggtcgcca
     7921 cggcgatcac gatctccgac gcagcgaagg aatccccgat gcacttgtgc tgaccggccc
     7981 cgaacggaat gaacctgtgc gggcgtggcc gatccgccga gtcggtgctc cagcgatccg
     8041 gatcgaattt cccgggctcg tggtacagcg cggggtcccg atggagcgcg taggggctgt
     8101 aacccagttc ggctccggcc gggatcgaga cgccaccgag cttgaccgga acaagggcgc
     8161 gcctggtgaa cagaagcggc gaatgcaggc gaagcgcctc ctggaagacg ttgttcgtat
     8221 acgtgagacc ggcgaggtca gagggacgga cgggccgcgt gccgatcact tcgtcgactt
     8281 cgtcgtgcag gcgcttctcc acctctggat gacgggcgag ttcatggaag atccaggaca
     8341 gcaccgtggc cgaggtttcc gtcgcggcga agaagatgga gatcacttcg tccctcacct
     8401 gttcgtcgct catcgtctcg cccgtctcgg cgtccaccgt ggacaacagc agggacagaa
     8461 agtcgtcacg gcccgaccct tcggtgccgt accgcacgat cacctcgtcg atgatccggc
     8521 gcagccgtgc ggcggccgtg tcgaaccggc ggttcatcgt gatcgggaac cggtccagcg
     8581 ccttcggcat gatcgctcgc ctcaggatgc cctccacgag cacggggaac gagcggtgca
     8641 cttcctcgac agccgaccgc ccgaggtcgc cggagaagat cattgccgcg accgaggaca
     8701 gcgcgaaccg gcgcatttca gtcgtcaccg agatctcttg accggcggtc cacgacgtgg
     8761 acatctcgtc cgccaggcgg cacatcattt ccgcgtaggc ggtgatgtga ttccggtgga
     8821 acgccggttg cagcagacgg cgctgcctgc ggtggaactc accgtcagcc agcggaagac
     8881 cgttgccgaa cagcgggcgc aacctgtcga agaccctgcc gcgtccgaag ttcttcgcgt
     8941 caccgaccag tacggtctgg atcagctccg ggctggtgag cacgtggacg ggccatgtgg
     9001 ccacgtcgac cctcacgacg tcgccgtgcg tccgcagcga ctccaggaac gctatcggcc
     9061 tgcgccacaa ctgcagcgcg tggccgagga cgggaaggcc ccccggagcc accgccgcct
     9121 cgcctgacgg gttgacgtgt gccacgggcc acctctccgt cgtaccgctc atattcccgg
     9181 gaccagatcc gggcgggtgt acgtggactc gaggcccgcg acccaccgtt catcgttgta
     9241 gcgggtgcac tcgtaccgct gccagaggtc cgcgccgatc atccagtcct gatagctctt
     9301 cacgcagcgc gcgaccccgg cgcgcgccga ggggtccgtc accccgagag tgtccagcac
     9361 gtcgggcagc ccctgtgccg cggtcaggaa gtcctccacg cgggagcggg tgcgctcctg
     9421 gacggcgagc acggcctccg gcagtgagca ctcgttccac caggcaagga gggaaaccag
     9481 gttgttgttg tccccacagg agaactcctt gcgcagggag aagacgtcgt tgccccatga
     9541 gatgacgtcc agggcactgc tcatgaggtc ctggaacgcg gagctgtcgt acacctccgg
     9601 gggcacttcg acgcccaggc cggcctccac catgtccatc atcggcagca gttgggagct
     9661 gtgccggcgc atgcgcacgt agtcctcgat cgtcggctgc tgtgcggcat tccggttgac
     9721 cgcctcctgg tcgagggagc gcagcatgag ggggatgtgc gctcggtagc gctccctgat
     9781 ggtcgtcggc atctcggaaa gaatgcggtc gcacaggtcg atgaacccga ccaccagcgg
     9841 attctcgcgc agctggggcg cactgtcgac ctgccccgtg gcgaggtacc cggtgatggc
     9901 atcggtgagg ggaggccagg cctccagccg ctccgccctg atgaggtggt cgtgctggtc
     9961 gtcgagtacg aacgaccagg ccatccactc ggcaagcagc acgacgtgcc ggtagggcgc
    10021 ctcttgacac acccgcccgg aaaggtgccc gaagccgatg cccgcgaact gctccgccgc
    10081 gtcggtgatc agcccatggc gcagcgccca cgaggtcgcc tcgctgttgg cccgacccga
    10141 ctgcggatgc ttggcggatt cgaacgggag gtaaaagtcc ggaatggtga aggagtcaag
    10201 aagggccata aatctctcca taaggaatcc gaattcgcca cttcccgccg gaatggttct
    10261 cgcgttcacg accaggcgat cacgcctcaa cacgctgtgc tccctatgga cttgcgatca
    10321 ctccggcggc agaattggtc gttttgtatg tccacgcgag aacatccgac acttcatgtg
    10381 gccaattaac gcgcggatcc gagcagactg tcaatataat ccggccgcgg aattccgaga
    10441 cacattgggc aatcgccagg tgactattca atgggtcata tgcgaatgcc ataattgtgg
    10501 cgccggggag gccgacgagt cgtccacaca cgcgggacgc gcgcccccca caggacagcc
    10561 ccaggtcaga tgggcagtcg ccgcagcttc agcaccggtg gcagctggac gtgtggacga
    10621 gggcaggcga tgggcagggc cggcggggag ggagcagcgg gcgcgcggga gtccgtcgcg
    10681 cgcccgcgtc cgttctcgcg cgccgacgtt tcgcccgacg cgccacccag gttcaattgc
    10741 ccgtttccaa cggtttcccc gaatcggctg ggcgcatgta accagccgct gcggcgcaga
    10801 cagacatgcg cgttctcccg gccaccggtg cccgcgcgtt cgagcgaaca gggccgccga
    10861 gggtccgccc gcttccccgc cattccccac ggcgccctcg ccctcagcag tgagctcttt
    10921 cagcgttgcg gtcgggacgc ggctggggcc atcatcttca ccgtgccgca gaccgacccg
    10981 cagcgaagtc gtcacggtcg tctccctggt gtcctccagg gaaaggtggc cggaactcgg
    11041 tgagcaggag agcgatgtcg tcggctcggt acgagaagct gcgggcgttg tgcagaagcc
    11101 ggtcggcgag ttcgtccagc gagtccgcac gggcgtgggc caaggacgct cgcagccggt
    11161 cgatccccac gtcgatatcg gttccgggtt cctcgaccag tccgtcggtg tagagggcga
    11221 ggacggatcc cggtgggagg gcgatccggg tttcggggta ggcgctcgcg cgctccacac
    11281 caaggatcgg gccgacctcc aggtcaagga catcggtcgt cccgtcgggg cggcggagca
    11341 agggtggggg gtggccggcg gtgacggcgt aggcatggtg gtcttggggg ccttgggggt
    11401 cgaagtagat gcagcagcag ctggccagca gcccgggtcc gaggtcgatg agggttcggt
    11461 tgacacccgt cagcacatcg cccggcatgg gccccacggc cgcgaacgcc cgcaccgcac
    11521 tgcgcaactg ggccatggtg gcagcggcgg cgatgctgtg cccctccacg tctccgatca
    11581 cgagacagac cccgctctcg gtggggatga tgtcgtacca gtcgccgccg atgtccattc
    11641 cgctggtgcc gggcagatag cgcacgacgc tacggatgcc cgggaccctt ggcagccggt
    11701 gcggcaggag cgccttctgc aggccacgcg cgagggcgaa ctccgagtcg tagagccgcg
    11761 ctcgttccag agcctgggcg atcagcccgg cgagtgcagt gaggacaccg cggtccctct
    11821 ccgtgaactg atggatgtcg tcgaagccga ggatgcaggt gccgacaggg cggctggagg
    11881 cgatcagcgg gagatacgcc cacgagctca cttcgcccgt ggggatgccc gggtagcccc
    11941 gggaaaggtc cttctgcgac tcgatgaaga gcggagcgcc ggatgtcagg gtctccgtgc
    12001 cgggcaggcg ggcgtgcagc ggtacgcctt ccagccagtc caggaagtct tcgtggtggc
    12061 cggtgtggaa gagcaggtgc atcgttccgt cgcggaccac gtagatcgcc agttgctggc
    12121 ctccgaaggc cggcaggagc tggtcggaga cgacttcaca gacttcgcgg gcggtgaccg
    12181 cctcggtcag cgcgctcccc aactgcagga cgtggtacat gacgcccagg cgcgacggcg
    12241 ccgtggcggg tgatgccgac gaggcggaag tcgtcgagtc cgggggtggc cgaccgacgg
    12301 gcacgacccg gccggtcact ccgtccgcct ccggatggag ggagaaggag agccaccggt
    12361 cgggcgggcg gcaggcgagg aaggaggccg gcgactgcga gatcatcgcg gaccggtgcc
    12421 ggtactcgac gtcgggatcg gacagccagg tcacaacatc ccagaggtaa tggcccagca
    12481 gctcgtcgcc ggacgcgcca agcagtcgca gggcactgtg gttggcgtag gtgacccgtc
    12541 cgtcgggggc gagggagaag accccgtcgc gcagccgctc gaccgctgcg acggccatgt
    12601 ggccgacccg ggcgtcgacg accgccccga ccaggtgggt gcctgcccgc gggtcgtcgg
    12661 cgttcggcac gcggccccac aactcgaccg tgcggtaccc ctcaccgccg tgcccggggt
    12721 ctgacaagcg gacgcgccta ctggtggtcc ggccgtccat ggctgcctct cgggcgaagg
    12781 ctcggaaggc agtgagatct ccggggtgaa ggcgggaagc gagcgtgtcg gctcgttggt
    12841 cgaaagcatg agggtcgaga ccgcagattg cgcagagctc gtcgtccacc aggaaggtgc
    12901 cggtgccgag gtcccactgg aagaagccga cctgcacggc agctccggag ggagccggga
    12961 tctcgacggg gaccgtttcc ccgtcgcatt ccacaggatc gccggtacgg gcgcggagtg
    13021 cggccaggga gtcgcccagc cggctggcga cactccgcag gtggcggcgc cgggccttgg
    13081 acagcccttc gctgcctggt gttgccgccc ggacgatcgc cagcgacccg aaggtctctc
    13141 cgcctgtgcc caccggcacg gagcaggagc cgaaggcgta cggcagggcc actgcgagct
    13201 gcggataccg gcgcatcgtc tcctctgcgt cggccaggtg gaccgtgcgc ccaaagctgt
    13261 acgcctcggc gaccgggatg gggccgttca ccggaatgag gcgccagcca ccgagcaggg
    13321 aggggggcac gccgcaggtc gcggcgagca cgatcgaccg gcggtcgctg gagcgcagaa
    13381 agacactgcc tccgtaggcg ccggttcttt cgacggcttc gacgacggct gcggcaagta
    13441 gatcttcccg ctccgccgtc ccgccgacgg tcatcccgtc catgcttcca gtgtgcgcag
    13501 gtcggcacag gtcagctcgg cagcaaccca gggtgacgaa ccgattgccg ttcgcaggct
    13561 ccgcaccgga gtacctgccg cggaaatcca cgtatccccc gcctcggtgg ggcctgcccc
    13621 gtacggggct ccgcagggcg acttcccgaa gtccgcaccg ccgcgcagtt cgacgcccat
    13681 gcacccggtt gtcgtcggcg tcgcggatca cgtcagtcgg caattcgtcc caagcggcga
    13741 gtggatcaac gccgggccgc accgtacgcg gctcgagtac gtggtcggca ggctcctgcc
    13801 gcctctcccc ctgctgcgcc cggcggcatt tgcggcggtg tgccgggcag gtcaggctgc
    13861 ccggcacaca cgctcgtgct ggtggtcggg gtgtgctgac gacgggcaga caccccgttc
    13921 accggccgag ggtcagcggc cccggttcca ggattcgatg tcgaccgtgt tgccgcggtg
    13981 gtcgcgcagg acggcctcgt cgtagcggct gtcccacacg gaggtgcggc ggtcctggta
    14041 gaggtcggtg cgggtgtcgc gacccatgcc ggtgtggacg cggacggtcg agcggccggc
    14101 gaggatgtag tcgtcgaagc agtagcggtt gccgtcgagg tcgcgcaggg tccagccgtc
    14161 caggtcgacc gagcggcggc tggtgttggt gatctcgacc cattcggcgt tcagggaccg
    14221 gttggagcga gtttcgcgcc gggggctgtc ggcatgcacg gcgctgatct cgacccgcgg
    14281 gtgctgacgg taccggcggt cgcggtcgtc gtcgtgggcg gaggccggca gagcgacgac
    14341 cgtgacaacg gcgccggcag cgaggacggt cgccatgaca cgacgggcgg tcgaagaagc
    14401 agacatgagt tgatgtcccc tcaagtacag ggcccacagc cgatccaggg cggcgggggg
    14461 cgatgcggat tcccggccgt gtcggccgag aacccacaca ctggagcact ggcggaacca
    14521 acagccgacg caccaggccg cgttaccaat cacggacact tctgtaactg tcgcccatat
    14581 cggtcgcgcg agtgccgggc ggggccctga cattaactga ccgctacacc gaccgttgaa
    14641 ccatcaacgg cgagccccta cgcgcttcgg cccgccaccc actgcgccac cccgcacacg
    14701 acctgccgga ggccgcaagt ctccgtaaca gccgttcttc acgcttcttc gcacacctgc
    14761 gcccgtgccg tacgcgggac cggaacatcg agggcttctg ccgcgacggg ggaaccgcgg
    14821 cagaagccct cactccaccc catgccccca ccccaaccgg accactccca ccaggcactc
    14881 aactggccgg aagctgccac ctgcacggct ccggcgccgt ccgtgagagc gctgcgccgg
    14941 ttctacgacg tccgccgcac ctgcgccgtg gatgtcagtc gatcaccagg acgacttcca
    15001 ggcgtcgcgg gccatggacg ccttcgaccc ggtcgagttc gatgtcgctg gtggcggagg
    15061 ggccggagat ccaggtgagc gggcgggtgg cgtcgagccg cggcagggcc tgggagacgg
    15121 aggcgaccac ctggtcggag gcgttgacga cgcagatgtg gagatcgggt acgagagtga
    15181 gggcccggcg gccttgcccg gggccggcat cgaggacgat ggtgcctgtc tcggcgacgg
    15241 ccagcgcaca gccggtgatc acggcgtcga tggagtcgag ttcggcggga accagggggc
    15301 cggcgtcgaa gcactgctcg actcgggtgg aggccagcca gccgctgggc aggcccggcg
    15361 ggacgaccac ggtgcgcgcg ccttggtcgg cgaggagccg gccgatgagg gacggaagat
    15421 ggtgctcggt gctgcggtgc acgacggccc ggtagtcggt gaggttctcg tggaggaggt
    15481 cgagcaacgc ggcggggtcg tcagatgtgt ggctcgccag gtagtcgcga gtgacctcgg
    15541 gggcatcggg ggcatcggcg agcgcactgc gcactttggc gagaatgcgt tcgcgggagg
    15601 aggaccgaga agtcatgcgt ggttcttctt ccaccagtcg cgaaacggtt cggcgggcag
    15661 gtccggcagg tcccggctgt tggtccactg gcgcgtcccg gggccgggga ggcgctcggg
    15721 gtgcagcttc cgggtcctgg acgcgaggcg ctctccggcg gtgagggcgg ccgggtggtc
    15781 gagaagccag gtcgccgcct tgatcgcggc cttctccagc cggtggcccc tgccgccctg
    15841 gtcggcgact ttctcgcgca ggtggaccag gacttccggg atgtcgatgg ccaccgggca
    15901 gacctcgtag caggcgccgc acaaggagga cgcgtacggc agcgaggcgt cgacctcgga
    15961 ggcgatgccg cgcagttggg gggtcaggat ggcgccgatg gggccgggat agggggagcc
    16021 gtaggcgtga ccgccggccc gttcgtagac cgggcagacg ttcaggcacg ccgagcagcg
    16081 gatgcagcgc agcgcctggc gtcccacctc gtcggcgagg gtgtcggtgc ggccgttgtc
    16141 cagcaggacc aggtggaacg tgcgggggcc gtccccgtcg gtggtgcccg tccacatcgt
    16201 ggtgtagggg ttcatccgct cggccgtgga ggaccggggc agcagttgga ggaatacctc
    16261 gaggtcgcgc caggtgggga tgatcttctc gatgccgacc accgagatga gcgtctcggg
    16321 cagggtcagg cacatccgcc cgttgccttc tgattcgacg acgacgagcg ttccggtctc
    16381 ggcgatcatg aagttggcgc cggagatgcc caccttggcg cggaggaact tctcgcgcag
    16441 gtggagtctc gccgcctccg cgaggtcggc ggggcggtcg gtgaggtcct ccggtgccgg
    16501 gcgtccccaa cttgccatgt tgtcacggaa gatgtcgcgg atctcgcccc ggttgcggtg
    16561 gatggccggg acgaggatgt gggagggcag gtcgtctccg agctggacga tcagttcggc
    16621 gaggtcggtc tcgtaggcgc ggatcccggc cgcctcgagc gccgtgttga ggccgatctc
    16681 ctgggtggcc atggacttga ccttgacgac ctccgtctca ccggtggcct tcacgaggtc
    16741 cgcgacgatc cggttcgcct cgtcggcgtc ggcggcccag tgcacggtgc cgcccgcggc
    16801 ggtgacggcc tgctcgacct gctccaggta gcggtcgagg tgtcgcaggg tgtggtcctt
    16861 gatctgtttg ccggcctcgc gcaactgtgg ccagtcctcg agttcggcca ccgccgccgc
    16921 acgcttggcg cggatggtgc gggtcgcgtg ccgcagattg ccgcgaagtg tcgtgtcgcg
    16981 tacggcgtcg cgtgccgcct tggggaaggc cggcattccc atgaaggtcc cactcatacc
    17041 agcggctcct cttccgtgct cgcgagaatc tccgcgaggt gcagtgtccg ctgcggcgcg
    17101 tcctggcggc gcagcatgcc gccgatgtgc atgaggcacg aattgtcggc gccgcagagc
    17161 acgccggcgc ccgtggacag ggcgttgcgg agcttgtcgg cgcccatcgc ctcggacacg
    17221 tcagggttct tcacggcgaa ggttccgccg aaaccgcagc attcctcggc gcccggcagt
    17281 tcgatcagtt ccagacccct gaccgcttgc agcagccggc gcggccggtc accgaggccg
    17341 agcatccgca gcccgtggca ggaagggtgg taggtgacgg tgtgcgggaa gtacgcgccc
    17401 gtgtccgtca cacccagtac atcgacgagg aactcggtca gctcgtagac gtgcggcacg
    17461 agcgatgccg cggcctcggc cagttcttcg ccgcggcctt cggccttcgc tctggcaccg
    17521 atccggggat agttgtcgcg aatcatggcg acgcaggaac cggaaggcgt gaccacgtgg
    17581 tcgtagtcgg cgaaggcgcg ggccgtgcgg cggaccagcg gttcggtctc gcgccggtaa
    17641 ccggtgttga actgcggctg gccgcagcat gtctgggcag cggggaagtc cacatcggca
    17701 ccgaggcgtt cgaggagtct gacggtggcg atggccgtgg acgggtagag ggcgtcgttg
    17761 acgcaggtgg cgaacagggc gacgcgcatc agtagttcct ccgggccggg gtgggccggg
    17821 cggcagccgc gtccccctga cgggcgcggc gtcggcccgg gcgctcgggc accgcgcgca
    17881 gctcatcggt catgtgcagg ccgccgacga gccgcagcag cagctcgaag catgcgcgcc
    17941 ctctcgcgca ggtcctcgtc cggcactgcc ctgatggtcg tcgaacgccg agacctgggc
    18001 ggcgtagcgg ctcaccaggt cgtcgacgtc gtccaggcgg tcccggacga cggcgcgcag
    18061 ctcctctgat gccggagcac cggcatcgtc cgtcctgcgc ccgccgaagg acggctctgc
    18121 gtcgccggca gggggtgcgt tgtgcatgtg cccattatcg gcgaggctga gccggcgggg
    18181 ccggcggggc cggcggaagt ggccgcgggc tcagcggccc gtccccgtcg cacgacgcgc
    18241 ggcagcgccg ggtgctgatg tccgggtcgg ccggcgatct ggccgcggga gtccgggcga
    18301 ccgcgcctcg atcgcccggc gctgcgggca gcacgcctgg ccgtccaccg gcgcggcgtg
    18361 cgagccctta ctcagcgggg acggcggcgg tcgtctggac acggccgtcg ccccggcctg
    18421 cggtgacacc gtgacctgga agtcgtccga acgcataccg ctgatctctc cggcctgcgg
    18481 ccgtctgccg acccgggcca ccgaagaggt cggcgcgccc cgcgacgtgc accggctcct
    18541 gctcggcgac cgcgcgatcg gtgagcagca ggcagcgtcg gcaagcgccc ggtccgggcg
    18601 agcgcctgcg ggaccggctc ggcgccgtac ggcaggacgc cctgcccagc ctcccccaca
    18661 ctcggcgctt cggcgccggg cctctcagcc gccggctggg gcggcagcgg cgggggccgc
    18721 gttgtgggcg ccggccgcgc tgtcgacgga aaccgtcgaa cgcgcgcatg cggcgtcctg
    18781 gccagaaggc ctcgaggagg gttgccgcga tcaccgtggg agagatcagg accgtaacca
    18841 cagcgcgggg cacaccatgt tcaccatgtg gatgtgccga tggacgcaag gcacctgaac
    18901 cggcctggac gcggccgctt ggagtgtgct ggaaggccgg gccacccgag cggcatccgc
    18961 aggcagccgc acctcaaccg tgcccacacc cccggcagac ggtccggctc cggccggcgg
    19021 tactcgagtg acgggtggct atgcgccgta ggtgagggtg gtcatcatgc cggattccga
    19081 gtggtaggtg ttgtgacagt gcagcatcca gtggccgggg ttgtcggcgt cgaagtcgag
    19141 gacgagtttg ttgtggggca ggacggtggc ggtgtcctta cgggcgccgt gggagtcgat
    19201 gccggcgagg gcgtaggtgt ggccgtggag atggacgggg tgccacatgt cggtggcgtt
    19261 gatgacgacg agccgtacgc gttcgccgcg ttcgatgcgg tggacgcggt cgggtgtgta
    19321 ggggcggtgg tcgatgcccc agtcgtagtc ctccatgccg ccggtgaacg tgaccttgag
    19381 gatccggtcg ggtctgcgcc ggtcgagttc aacggattcg tggggcctga ggcggcgcgc
    19441 cgacggcagg acggcgcgcc gcaactccgc ggggcgggcg gtggggccgg gaagtgcgcc
    19501 gcttgctgtg cgaaggacgg ccatggcggc gccgcccttc ccttcggcga gggcggtgag
    19561 cgggaagacg ccgtccttcg cggtgatcag cacgtcgtac cgttcgccca tgcccaggag
    19621 catggagtcg gtccggtggt gacgtacggg gaaaccgtcg ctgtgggtga tcgtcatttg
    19681 atgaccgccg agggccacac ggaacggtgt ctcggcgccc ccgttgatga tgcgcaaccg
    19741 gatccggtcg ccgggtctgg ctctgaactg ggtcggatcg tcgggtgtgc gtccgttgat
    19801 cagatagtgc ggatacgcga cgtcgcccgc atggccgccg agcagtgcgc tccgggcacc
    19861 cttcatcagc cgaccgggcc cttctccatg gtgctgtgag ggcgacgcgt cttcccgctg
    19921 cggggtgcgg tcgtcctcgg gcgcgtgggc cctcggcggc ccgtacccgg ccgcgattcc
    19981 tccggagggt ttggacggcg cgggccggac gccgtggttt tccccgcgcc ggtgcgcgga
    20041 gccgtggctc atggcgggct tgcccttgcg gagttggtcg aagacgtcct cggggctgga
    20101 gccgccgacc ccgtcgatcc agtcgtccag caggacgatc cattccgcgt cgtaggcgag
    20161 gggctcgttg gggtcgtcca cgatcagcgg cgcgtacatc ccccggtcg
//
