LOCUS       NZ_BMWB01000001        11368 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000001
VERSION     NZ_BMWB01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 943286)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 769008
            Orig. end                         :: 780376
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6368)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(97..1818)
                     /locus_tag="IE198_RS03610"
                     /old_locus_tag="GCM10010381_07430"
     CDS             complement(97..1818)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487580.1"
                     /locus_tag="IE198_RS03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189882451.1"
                     /transl_table=11
                     /translation="MNPERGALRALLPVLGAHRAMTVRTFGAALVDQAALVALVTLVAH
                     TVGTAVVERQAPGPGTVAALLVLVTARALATWREMDLSHDLAYRVLAEMRIRVFDGLAR
                     SAPARVGGRRSGDLASAALGDVEALEFFYAHAVAQLAASGTVFGGGTVALALLDPWLLI
                     AVLPVAALLVLAPLLESRGRAARGARTRAAAADLSAETVETVDGLRELLAFGALDTRRE
                     RLRAHGRRLGDAQRAEQAWEADASAMRDLLVVAAVVGVVLAAAHTVSGAWAPAAMALAL
                     GVLAPVADSAAALGQAGGLRAAAARVGAAVRAPAGAPAPAAPWPVPEGPLGLRLRDVRF
                     DYGGRAVLDGVDLTIRPGETLALVGVSGAGKSTCAHLVARFWDPAGGAVELVPAAGPPV
                     DLRDVAESDLRRAVAVVGQDAPLFHGTLADNLRLAAPEATDDELADVARRTGVDRIADG
                     YDTPVGERGSTLSGGQRARIALARALLTHPRVLVLDETTANLDTEGDAAVSAALRDGAP
                     SRTTLLIAHRPSTIRRADRIAVLEAGRVVQTGTWEELMREGGAFARVVARGRPHHG"
     gene            complement(1815..3551)
                     /locus_tag="IE198_RS03615"
                     /old_locus_tag="GCM10010381_07440"
     CDS             complement(1815..3551)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847806.1"
                     /locus_tag="IE198_RS03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07440"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_189882453.1"
                     /transl_table=11
                     /translation="MMLHPELLRAARIARRPLLAATALLAAVAATHLAQAVLLALALAG
                     IARGDTDALPLLLGAVLAAVLVRAGLVRMQRRTAVGAGAAVRTGLRDELLVRLGRTGPR
                     QQAGARAGAVRATLVDGVEGVDAYVSRYLPQLLITCAVPPLLLSAVAAVEPWAVVALAP
                     ALVLALFAPRWWDKLLERRGQQHWGAYEALSADYLEALQGMPSLRAAGAVGRTRARLEE
                     RSAALHRATVAKLRVSLVDTGITDLAVQGGTVAAALVACTAAVSGQGAPAGTYLVLMLA
                     SECFRPVRDLSREWHSGYLGVSAADGIAELRTEEGGVPDEGRRVAAWQTAPEVRFEDVH
                     FTHPGGRRPALRGVSFTAPAGRVTAVVGPSGAGKSTLLALLLRRADPDRGRVLVDGADA
                     AAYTLDSLRRGVAVVSQETYLFHASVAENLRLGAPGARDTALRDAARSAGIHDEIVRLP
                     EGYDTQVGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDERREARIVGELLRA
                     ARGRTCLVVAHRLDSVRHADRIVVLDGGRVDAVGDHAGLLSGEGVYARLVAAGHTAEGK
                     AA"
     gene            complement(3548..4993)
                     /locus_tag="IE198_RS03620"
                     /old_locus_tag="GCM10010381_07450"
     CDS             complement(3548..4993)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512966.1"
                     /locus_tag="IE198_RS03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07450"
                     /product="nitroreductase"
                     /protein_id="WP_189882455.1"
                     /transl_table=11
                     /translation="MVHSVSGALALARSAQTPGPDLPAGPATVPLPGEPLPVPSGLDRL
                     LRLSVAGDRLRPAPSAGGLHPVDTYLLLGAGCGLPPGVYVHDPAHHRLHRRGSAPKPAP
                     EGAVAVLGVTARRTVSHYGHRAWPLVLLDAGHAAAALALAGAPRVCLDADGRLLSAATG
                     AQRALVAVQLTPLLAPDALARWAARGSGRGVAPPAGPEVLRTAVGVLGELAASGDGSGT
                     WQVAPGPWLPDAMLLSRRSAPPGLTGLPSRTALARVLAAAQAASPEGPQWSMAVAGARP
                     GLLTGPSTPDAAHPALAGRSEAAPRGATAPDHAVAEREVRPAYGAGPGRATARDRAASG
                     HRPTARRGTAAGPRVALRSQTAPAAEEPPPLRLRRLASGDVLPTLAHWAAGQGWIARAG
                     AVLLAHGCPSDATPAQVRRDHLAAGYGIGHAQAVATSLGLHSRPVGSWQCADLGAALGG
                     PAGRDWVVHGLALGRTTEGDEPS"
     gene            complement(5001..6368)
                     /locus_tag="IE198_RS03625"
                     /old_locus_tag="GCM10010381_07460"
     CDS             complement(5001..6368)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="IE198_RS03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07460"
                     /product="YcaO-like family protein"
                     /protein_id="WP_189882457.1"
                     /sec_met_domain="YcaO (E-value: 6.4e-46, bitscore: 153.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTLTLDALVDPVCGLIRGVEPVPHPSGAPPRYTAMTADVCDAR
                     RFGAWPADRVSLGTTFGDPAGARIAAVAEAVERYCGNRLPPPGHPDAPRRATAAQLVAE
                     GRTVYGPGELPAYADWQYARPGFEYRRLTPDTPALWARAQENGDECWAPVALTHLNWRQ
                     GDLRSLTRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIEPASVP
                     GLARDLEGCDLDVSIVEMPSEFAPCMAALVHDPARGIHAAGFACRYDAAEAARKAVLEA
                     VHTWVFTQGTTDADGWVFRAIDAGMLARSLYLDHRADRRYLDDCGTDFRAVRDLGAHVQ
                     VWLDPRMTPLADRFTRPALGVVPVDAVAKGSRAALDERLAAGGHRVITLDLTTEDVAQT
                     PLRVARVLVSGLIPNAPAAFGYFGAPRFAQAALERGWREQAPAGPCDFTLAPPPHM"
     gene            complement(6365..7858)
                     /locus_tag="IE198_RS03630"
                     /old_locus_tag="GCM10010381_07470"
     CDS             complement(6365..7858)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048304.1"
                     /locus_tag="IE198_RS03630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07470"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_189882459.1"
                     /transl_table=11
                     /translation="MRTAFVPVSRARLATGVQLPAGGGPFPAVVLRTPYGLHRHLDEAR
                     GWAARGFAAVIQDVRGRYASEGDWHPYRHEDADGAATLRWVRGRHWSDGRVVAAGASYA
                     AHCALAATTNDDPQSRPDAVIAAVPALGLAETAREAGGVERLAARAGWWAAHGDRPDSD
                     VTALDKAVAQDPRLLEHLPLTAFPARLGRPLPSWAALWDEPLRPAPVPHAPMPILAVGG
                     TRDPFADDTLRLWANWPGPARLLIGPWGHGLTSEPAPEARPGHRIRLGELYVRWARAAL
                     DGTLPPGRRGAIALGGSEHWYPAEPEAGERTSRPFGTPSGLRLLQGGTFVADPERPVRS
                     DELNVERRAVPDRVLLVTPPLPRPVDLVGTAEARLCATADTPTADWAVRVVALDLAGHA
                     EPLATGIVRRSDPVGAEAVFRVPLGLVARRLPAGSRLRVEVAGHHFPAHARNPHTGADP
                     VHATRLAASRRTVGTAGSSLLLPVLSGRRPVDPLQETCS"
     gene            complement(7863..8654)
                     /locus_tag="IE198_RS03635"
                     /old_locus_tag="GCM10010381_07480"
     CDS             complement(7863..8654)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470988.1"
                     /locus_tag="IE198_RS03635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07480"
                     /product="hypothetical protein"
                     /protein_id="WP_189882461.1"
                     /transl_table=11
                     /translation="MATARLAPGVALVTVPGHGLAVRTQDGEFLRVDTAGADQEALVAH
                     LTHGGGEDTELARLRAAFDDAGLLARTDAPRTPLAGRTVLLLGAAVLTEPLARFVRAEG
                     GDVRHTEPDGLGGGDPSTAVVWCLDSPVPPGLWDKADELPALGTAWLRCHREGTTVWIE
                     PLAAARGDVTSADVRLRRLAATPAHRELAAYWAGSRTDDTGPAHTAASAALTAALLTAD
                     LIAWAAGRTAARRLRRLDLRDLHVTEHPVLPVPAVAPLSDR"
     gene            complement(8736..8873)
                     /gene="amiA"
                     /locus_tag="IE198_RS03640"
                     /old_locus_tag="GCM10010381_07490"
     CDS             complement(8736..8873)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129278.1"
                     /locus_tag="IE198_RS03640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07490"
                     /product="streptamidine family RiPP"
                     /protein_id="WP_189882463.1"
                     /transl_table=11
                     /translation="MEQHKVFTPIAEQGQLAHLSATHSNALVENPFDDNAVAVETDSDK
                     "
     misc_feature    8940..8953
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.45"
                     /tool="antismash"
     misc_feature    complement(8940..8955)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(8941..9813)
                     /locus_tag="IE198_RS03645"
                     /old_locus_tag="GCM10010381_07500"
     CDS             complement(8941..9813)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019766570.1"
                     /locus_tag="IE198_RS03645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07500"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189882465.1"
                     /transl_table=11
                     /translation="MTTVTTRSDAAPERPGRQGTVRTEGLRFGYGGREVLAGVDLDIGA
                     GECVALVGLNGCGKSTLLRLCAGLLRPAAGRVRLGGDDLARLSRRSAARRVALLHQSAP
                     AVPGMTVRQLVRQGRYAARGPLGMLRDGDDAVCSRAMADVGVSEWAERPVDSLSGGERQ
                     RVRLAMALAQDTRVLLLDEPTTYLDLRHQLEVMQTVVRLREERGLTVVMVLHDLGHAAR
                     FADRIVALRAGAVAVDGPPEEVVTPRLLAEVLGVAGRVGRDPEGGWPVCYPDHPMPDAE
                     LLQNENHIH"
     gene            complement(10030..11061)
                     /locus_tag="IE198_RS03650"
                     /old_locus_tag="GCM10010381_07510"
     CDS             complement(10030..11061)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613001.1"
                     /locus_tag="IE198_RS03650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_07510"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_189882467.1"
                     /transl_table=11
                     /translation="MRAVTSFLVRRRTLALSALLVAAVGCADLVAGRALGADDVWQVLG
                     GAGDPAARHVVLRLRLPRMLVALVAGASLGLAGTVLQSALRNPLAGPEVTGVTPGAVLG
                     AVAATGLGLAGWRSPTAVVVAACIGGFAGAGLLWLLTGRQKSDPAQTAVHGVLVSAVLS
                     GLTAMVLLVAPGELGSVVQWLVGSTEGRVWQHWVLLWPWAAVWAVVACVLAAPLTLLRC
                     GDEQAAAAGLAPGRARAAALVCAVALTAGAVSAVGALGFVGLLVPHLAFALFGADLRRA
                     LPGAALLGAAVVTGADAGAQWLSRALASALDADRLSVPTGALTTCVGAALLLVVARRSV
                     GPE"
ORIGIN
        1 ctgggccgca actcctcgtg ggcggagccg atctcgagcg gcgggctccg gcgaccggcc
       61 gtgcgacctc ttcccggcgg gtcgaaaccg aagtcgtcag ccgtgatgcg gtcgcccccg
      121 cgccaccact cgcgcgaacg cgcctccctc tcgcatcagt tcctcccacg tgcccgtctg
      181 caccaccctg cccgcttcca ggaccgcgat ccggtccgcg cggcggatcg tcgacgggcg
      241 gtgggcgatc agcagcgtcg ttcgggacgg cgcaccgtcc cgcagggcgg ccgagaccgc
      301 cgcgtcgccc tccgtgtcga ggttcgccgt cgtctcgtcg aggacaagca cccttgggtg
      361 ggtcagcagg gcccgggcca gggcgatacg ggcacgctgg ccgcccgaga gggtgctacc
      421 gcgctcgccg acgggcgtgt cgtagccgtc ggcgatgcgg tcgaccccgg tgcggcgggc
      481 gacgtcggcc agttcgtcgt ccgtcgcctc cggtgcggcg aggcggaggt tgtccgccag
      541 cgtgccgtgg aacagcggcg cgtcctggcc gacgacggcc accgcgcggc gcagatcgct
      601 ctccgccacg tcccggaggt cgaccggcgg tccggcggca ggaacgagtt ccaccgcccc
      661 gcccgccggg tcccagaacc gcgccaccag gtgcgcacac gtggacttgc cggcgccgga
      721 gacgccgacg agggcgagcg tctcgccggg ccggatcgtc aggtccacgc cgtcgagcac
      781 ggcccggccg ccgtagtcga agcgaacgtc ccgcagccgg aggccgagcg gcccctcggg
      841 caccggccac ggcgccgcgg gcgccggcgc gcctgccggt gcccgcacgg cggcgcccac
      901 ccgggccgcc gccgcccgca gcccgcccgc ctgccccagt gcggcggccg agtcggcgac
      961 gggcgcgagc acacccagcg cgagggccat cgcggcgggc gcccacgcgc cggagacggt
     1021 gtgcgccgcc gccaggacga cgccgacgac ggccgcgacc acgaggaggt cgcgcatggc
     1081 tgaggcgtcc gcctcccagg cctgctcggc gcgttgggcg tcgccgagcc ggcggccgtg
     1141 ggcgcggaga cgttcgcgcc gggtgtccag cgcgccgaac gccagcagtt cgcgcagccc
     1201 gtcgaccgtc tcgacggtct ccgcggacag gtcggcggcc gcggcccggg tacgggcgcc
     1261 gcgcgccgcg cggccgcggg actccagcag cggtgcgagg acgaggagcg ccgcgacggg
     1321 cagcacggcg atcagcagcc aggggtcgag cagcgcgaga gccaccgtgc cgccgccgaa
     1381 aaccgtgccg gatgccgcca gttgggccac ggcatgcgcg tagaagaatt ccagcgcctc
     1441 cacgtccccg agtgccgccg acgccaggtc cccgctgcgc cgccctccga cgcgcgcggg
     1501 cgcgctgcgc gcgaggccgt cgaagacacg gatgcgcatt tccgcgagaa cgcggtaggc
     1561 gaggtcgtgc gagaggtcca tctcgcgcca ggtggcgagt gcccgggccg tgacgagcac
     1621 cagcagggcg gccaccgtgc cgggcccggg ggcctgccgt tcgacgactg cggtacccac
     1681 cgtgtgcgcg acgagcgtga ccagggcgac gagcgccgcc tggtcgacga gggcggcgcc
     1741 gaacgtacgg acggtcatgg cccggtgggc gccgagcacc ggcaacaggg cgcgcagcgc
     1801 gccgcgttcg ggattcatgc ggcttttcct tcggcggtgt gtccggccgc gacgagacgc
     1861 gcgtacacgc cctcgccgct cagcagaccg gcgtggtcgc cgacggcgtc cacccggccg
     1921 ccgtccagga cgacgatgcg gtcggcgtgg cgcaccgagt cgagccggtg cgccacgacc
     1981 aggcaggtgc ggccacgggc ggcccgcagc agctccccta cgatgcgggc ctcgcgacgc
     2041 tcgtcgacgg cactggtcgc ctcgtcgagc acgagcacgg gcgcgtcggc cagcaacgcc
     2101 cttgccaggg cgagacgttg acgctggccg ccggacaggg tggcaccacg ttcgccgacc
     2161 tgggtgtcgt agccttcggg caggcggacg atctcgtcgt ggatccctgc cgaccgggcc
     2221 gcgtcccgca gcgcggtgtc gcgcgcgccg ggggcgccca gccgcaggtt ctcggcgacg
     2281 gaggcgtgga agaggtatgt ctcctgggag acgaccgcga ccccgcggcg cagcgagtcg
     2341 agcgtgtagg cggcggcgtc ggcgccgtcg acgaggaccc ggccccggtc cgggtcggcg
     2401 cgccggagca gcagcgcgag cagcgtggac ttgcccgcgc ctgacggacc gacgaccgcg
     2461 gtgacccggc cggccggggc ggtgaaggag acgccccgca gcgccggccg gcggccaccg
     2521 ggatgggtga agtgcacgtc ctcgaaacgc acttcgggtg ccgtctgcca cgcggcgacg
     2581 cgccgcccct cgtcgggtac gccgccttcc tcggtgcgca gttcggcgat gccgtcggcg
     2641 gccgacaccc cgagatatcc cgagtgccac tccctggaca ggtccctgac cggccggaag
     2701 cattcggacg ccagcatcag caccaggtac gtaccggccg gcgccccctg cccggagacg
     2761 gccgccgtgc acgccacgag ggccgcggcg accgtgccgc cctgcacggc gaggtcggtg
     2821 atgccggtgt cgacgagtga gacccggagc ttggcgaccg tggcccggtg cagggccgcg
     2881 gaacgctcct ccagccgcgc cctggtacgc ccgacggcgc ccgccgcccg cagcgagggc
     2941 atgccctgga gcgcctccag gtagtcggcg gacagggcct cgtacgcgcc ccagtgctgt
     3001 tgcccgcgcc gttccagcag cttgtcccac cagcgcggcg cgaacagcgc gagcaccagc
     3061 gcgggggcga gggcgacgac ggcccacggt tcgacggcgg cgacggcgct caggagcagc
     3121 ggcggcacgg cgcaggtgat cagcagctgg ggcaggtagc gcgagacgta ggcgtcgaca
     3181 ccctcgacac cgtcgacgag cgtggcgcgt acggctccgg cgcgggcgcc ggcctgctgc
     3241 cgggggccgg tccggccgag gcgtacgagg agttcgtcgc gcagaccggt gcgtaccgcc
     3301 gccccggcgc ccacggcggt acggcgctgc atccggacga gcccggcgcg cacgagcacg
     3361 gcggcgagca ccgcgcccag cagaagcgga agcgcatcgg tgtcgccgcg ggcgataccg
     3421 gcgagggcga gggcgagcag cacggcctgc gcaaggtggg tcgccgcgac ggccgcgagc
     3481 agggcggtgg ccgcgagcag ggggcggcgc gcgatacggg cggcgcgcag cagctccggg
     3541 tggagcatca tgacggttcg tctccttctg tcgtacggcc gagggcgagc ccgtgcacca
     3601 cccagtcccg gccggccggc ccgccgagcg cggccccgag gtcggcgcac tgccaggagc
     3661 cgacgggccg cgagtgcagt ccgagggagg tggccacggc ctgggcgtgc ccgatgccgt
     3721 acccggcggc gagatggtcg cgccgcacct gcgcgggtgt ggcgtcggac gggcagccgt
     3781 gggcgaggag cacggcacct gcccgggcga tccacccctg gccggcggcc cagtgggcga
     3841 gggtcggcag cacgtcgccg gaggcgaggc ggcggagccg gaggggcggt ggttcttctg
     3901 cggcgggggc ggtctgggac cggagggcga cccggggccc ggcggccgtg ccgcggcggg
     3961 ccgtgggccg gtgccctgag gcggcacggt cccgcgcggt ggcgcggccg ggcccggcgc
     4021 cgtacgccgg ccgcacttcg cgctcggcga cagcatgatc cggcgccgtg gcgccccggg
     4081 gcgccgcttc cgagcgcccg gccagggcgg gatgcgcggc gtccggcgtg gacggacccg
     4141 tcagcaggcc ggggcgggcg ccggcgaccg ccatgctcca ctgcggtcct tccggggacg
     4201 ccgcctgtgc cgccgccagg acgcgcgcca gggccgtccg ggacggcagg ccggtaaggc
     4261 ccgggggcgc gctgcgccgg gagagcagca tggcgtccgg caaccacggt ccgggagcaa
     4321 cctgccaggt accggacccg tcgccggacg cggcgagttc gccgaggacg cccaccgccg
     4381 tacgcaggac ctcgggtccg gccggcggcg cgacacccct gccgcttccg cgagcggccc
     4441 agcgggcgag cgcgtccggt gcaaggaggg gcgtcaactg cacggcgacg agggcgcgtt
     4501 gggcaccggt cgccgccgac agcagtcggc cgtccgcgtc gaggcacacc ctgggcgcgc
     4561 ctgccagggc gagtgcggcc gccgcgtgcc ccgcgtcgag cagcaccaac ggccatgcgc
     4621 ggtggccgta gtgcgacacc gtacggcggg cggtcacgcc caggaccgcg acggcgccct
     4681 ccggtgccgg cttcggcgcc gaaccgcggc ggtgcagacg gtggtgcgcc gggtcgtgga
     4741 cgtagacgcc cggcggcagc ccgcagcccg ccccgagcag caggtacgtg tcgacggggt
     4801 gcaggccgcc ggccgacggc gcgggccgca gcctgtcgcc cgcgaccgac agccgcagca
     4861 ggcggtcgag accggagggg acgggcagcg gctcgcccgg cagcggcacg gtcgccggcc
     4921 ccgccggaag gtccgggccg ggggtttgcg cggacctggc gagggccagc gcgccagaga
     4981 cggagtgcac catcacggcc tcacatgtgc gggggcgggg cgagggtgaa gtcgcacgga
     5041 ccggcgggtg cttgttcacg ccagccgcgt tccagcgcgg cctgcgcgaa gcgcggggcg
     5101 ccgaagtagc cgaaggcggc gggcgcgttg ggaatgaggc cggagacgag cacgcgggcc
     5161 acccgcagcg gcgtctgtgc gacgtcctcc gtggtcaggt ccagcgtgat gacccggtga
     5221 ccgcccgccg cgaggcgctc gtccagtgcg gcccggctgc ccttcgccac cgcgtcgacg
     5281 ggtacgacgc cgagcgccgg ccgggtgaag cggtcggcca gcggcgtcat ccgcgggtcg
     5341 agccagacct ggacgtgggc gcccaggtcg cgcaccgccc ggaagtcggt gccgcagtcg
     5401 tcgaggtaac ggcggtccgc ccggtggtcg aggtagaggc tgcgggccag catccctgcg
     5461 tcgatcgcgc ggaagaccca gccgtcggcg tcggtggtgc cctgggtgaa gacccaggtg
     5521 tggacggcct ccaggaccgc cttgcgggcc gcttccgcgg cgtcgtagcg gcaggcgaag
     5581 ccggcggcgt ggatgccgcg tgcgggatcg tgcacgaggg ccgccatgca gggagcgaat
     5641 tcggagggca tctcgacgat ggagacgtcg aggtcgcacc cttcgaggtc gcgggcgagg
     5701 ccggggacgg aggcgggttc gatgccgcgg gtggggccgt cgagatgcca ccacagttcg
     5761 agggcgtcgc gttcgacgac ttccaggagc cctctttcca cggcgtcgtc gagtccttgg
     5821 ccggtggcga ttccggcgta gttgagatgg tgggtgcggg tcagggaccg caggtcgccc
     5881 tggcgccagt tgaggtgggt gagcgcgacg ggcgcccagc actcatcccc gttctcctgg
     5941 gcccgggccc acagcgccgg ggtgtcggga gtgaggcggc ggtactcgaa gcctgggcgt
     6001 gcgtactgcc agtcggcata ggcgggcagc tcgccgggcc cgtagacggt gcggccctcg
     6061 gccacgagct gcgcggcggt ggcccggcgg ggcgcgtcgg ggtgccctgg cgggggcagc
     6121 cggttgccgc agtaccgctc gacggcctcc gcgacggcgg cgatccgtgc tcccgccgga
     6181 tcgccgaacg tggtgccgag cgagacccgg tcggccggcc acgccccgaa gcggcgtgcg
     6241 tcacagacat ccgcggtcat ggcggtgtag cggggcggcg ccccggaggg gtgcggcacg
     6301 ggctcgacgc cgcgtatcag tccgcagacg gggtccacga gggcgtcgag ggtcagggtg
     6361 ctggtcaact gcaggtctcc tgtaggggat cgacgggccg tcggccgctg aggacgggca
     6421 gcaggaggct gctgccggcc gtccctacgg tcctccggga ggcggcgagg cgggtggcgt
     6481 gcacggggtc cgccccggtg tgcgggttgc gggcgtgagc ggggaagtgg tgcccggcca
     6541 cctccacgcg cagcctggac cccgccggca gccggcgcgc caccaggccg agcggcaccc
     6601 ggaacacggc ttccgcgccg accgggtcgg accggcggac gatgccggtg gccagcggtt
     6661 ctgcgtggcc ggccaggtcg agggcgacga cgcgcaccgc ccagtcggcg gtgggggtgt
     6721 ccgcggtggc gcacagccgc gcctccgccg tcccgaccag gtcgacgggc cggggcagcg
     6781 gcggggtgac gagcaggacg cggtccggga ccgcacggcg ctccacgttc aactcgtcgg
     6841 agcgcaccgg tctttcgggg tcggcgacga acgtgccgcc ctggaggagc cgcagcccgc
     6901 tcggcgtacc gaacggccgg ctggtccgct cccccgcctc aggctcggcc gggtaccagt
     6961 gttcgctgcc gccgagcgcg atcgcgcccc ggcgtccggg gggaagcgtg ccgtcgaggg
     7021 cggcccgcgc ccaccgtacg tacagctcgc cgagccggat ccggtgcccg ggtcgtgcct
     7081 cgggggcggg ttcggaggtc aggccgtggc cccacgggcc gatgagcaac cgggcgggac
     7141 cgggccagtt ggcccagagc cgcagcgtgt cgtcggcgaa cgggtcacgg gtgccgccga
     7201 ccgccaggat cggcatcggt gcgtggggca cgggcgctgg gcgcaggggc tcgtcccaca
     7261 gggcggccca ggacggcagc gggcgcccga ggcgcgcggg gaaggcggtc aggggcaggt
     7321 gttcgagcag ccgggggtcc tgggcgacgg ccttgtcgag ggcggtgaca tcggagtcgg
     7381 gccggtcccc gtgcgccgcc caccagcccg cgcgggccgc cagccgctcg accccgccgg
     7441 cctcgcgggc cgtctccgcg aggccgaggg cgggcaccgc ggcgatcacg gcgtccggcc
     7501 ggctctgcgg gtcgtcgttc gtcgtggccg ccagtgcgca gtgggcggcg tacgacgccc
     7561 cggcggcgac gacgcgcccg tcggaccagt ggcggccgcg gacccagcgg agcgtggcgg
     7621 cgccgtcggc gtcctcgtgc cggtaggggt gccagtcgcc ctcggacgcg taccggccgc
     7681 ggacgtcctg gatcaccgct gcgaagccgc gtgccgccca gccgcgggcc tcgtcgaggt
     7741 ggcggtgcag gccgtacggc gtgcgcagca ccacggccgg gaacgggccg cctccggccg
     7801 gcagttggac gccggtggcc agccgggccc gggagacggg gacaaaggcg gtcctcatcg
     7861 cgtcagcggt ccgacagtgg tgcgacggcc ggtaccggca gcaccgggtg ttcggtgacg
     7921 tggaggtcgc gcaggtcgag ccggcgcagc cggcgggccg cggtccggcc tgctgcccag
     7981 gcgatgaggt cggcggtgag cagggcggcc gtcagggcgg cggatgcggc ggtgtgggcg
     8041 gggccggtgt cgtcggtgcg ggagccggcc cagtaggcgg cgagttcccg gtgggccggg
     8101 gtcgcggcca gccgccgcag gcgtacgtcc gccgaggtca catcgccgcg ggcggcggcg
     8161 agcggctcga tccagaccgt cgtgccctcc cggtggcagc gcagccaggc ggtgccgagg
     8221 gcgggcagtt cgtcggcctt gtcccagagc ccgggcggga cgggcgagtc gaggcaccag
     8281 accacggccg tcgacggatc gccgccaccg aggccgtccg gctccgtgtg gcgcacgtcg
     8341 ccgccctcgg cccgtacgaa acgggcgagc ggctcggtga gcacggcagc gccgaggagg
     8401 aggacggtac gtccggcaag cggggtgcgg ggggcgtccg tacgagccag aagaccggcg
     8461 tcgtcgaacg cggcccgcag gcgcgcgagt tcggtgtcct cgccgccgcc gtgggtcaga
     8521 tgggcgacga gcgcctcctg gtcggcccca gcggtgtcga cacggaggaa ctcgccgtcc
     8581 tgggtccgga ccgcgaggcc gtggccgggg acggtgacga gggcgacgcc gggggcgagt
     8641 cgcgcggtgg ccacggggtg ctccaggggg tcgagggggg tgcgctgcgg gtcgggcccg
     8701 cccggaacgg tgttccgggg gggcccgagg agggcttact tgtcgctgtc ggtctcgacg
     8761 gcgaccgcgt tgtcgtcgaa ggggttctcg acgagcgcgt tggagtgggt ggcggacagg
     8821 tgggcgagct ggccctgctc ggcgatcggg gtgaacacct tgtgctgctc catgagttga
     8881 ctctccattc gtcgatgtac ggactgtgcc gccggaccgg ccggtggcac agccaagaca
     8941 ctaatgaata tgattttcat tttgcaagag ttctgcgtcg ggcatcgggt gatccgggta
     9001 acacaccggc cacccaccct ccggatctcg ccccacgcgc cccgccacac cgaggacctc
     9061 ggcgagcaga cgaggcgtca ccacctcttc cgggggcccg tcgacagcca cggcaccggc
     9121 gcgcagcgca acgatccggt cggcgaaccg ggcggcgtgc ccgaggtcgt gcagcaccat
     9181 caccacggtc agcccgcgct cctcgcggag ccggacgacc gtctgcatga cctcgagctg
     9241 atgacgcagg tcgaggtagg tcgtcggctc gtccagcagc agtacgcggg tgtcctgcgc
     9301 gagtgccatg gccagccgta cccgctgccg ctcgccgccg gagagggagt cgacaggccg
     9361 ctccgcccac tcggaaacgc ccacgtcggc catggcccgt gagcagacgg cgtcgtcacc
     9421 gtcccgcagc atcccgagcg ggccccgggc ggcgtaccgt ccctggcgta cgagctggcg
     9481 caccgtcatg ccgggtacgg cgggcgccga ctggtgcagc agggcgacac ggcgggccgc
     9541 ggacctgcgc gacaggcggg cgagatcgtc cccgccgaga cgcacccgtc ccgccgccgg
     9601 ccgaagcagc ccggcacaga gccgcagcag ggtgctcttg ccgcagccgt tgagtccgac
     9661 gagcgcgaca cattcacccg cgccgatgtc gagatcgacc cccgcgagca cctcccgtcc
     9721 cccgtacccg aagcgcagcc cctccgtccg caccgtcccc tgccggccgg gccgttccgg
     9781 ggcggcgtcg gaacgggtgg tgactgtggt catgggtgtc ctccctgacg gggcggccgg
     9841 gggccgccgg gcgggttgca aaaaccggcc tcgccggcgt ttcaggcgcg ggggtgcggg
     9901 gacggagccc ccggttcggg atggggatgg accgcccaca ccgccaggtg tacggggagg
     9961 gcgcggaccg cggcaggcgc cgcgcaaccg cacccgccgc cgccccccgg ccggcccgcc
    10021 accgcgccgt cactcgggcc ccacactgcg gcgggcgacc acaagcagca gtgccgcgcc
    10081 cacgcacgtc gtcagcgcgc ccgtcgggac ggacaaccgg tccgcgtcca aagccgacgc
    10141 cagcgcgcgc gacagccact gcgcgccggc gtcggcgccg gtcacgaccg cggcgccgag
    10201 gagcgccgcg ccgggcaggg cgcggcgcag atcggcgccg aagagggcga acgcgaggtg
    10261 ggggacgagc agtccgacga agcccagggc tccgacggcg gagaccgcac cggccgtgag
    10321 ggcgacggca cagaccagcg ccgcggcgcg ggcgcggccg ggggcgaggc cggccgcggc
    10381 agcctgctcg tcgccgcagc gcagcagtgt caggggcgcg gccagcacgc aggccacgac
    10441 cgcccacacc gcggcccagg gccacagcag gacccagtgc tgccacaccc gcccctcggt
    10501 ggagccgacc agccactgga ccacgctgcc gagctccccg ggcgcgacga gcaggaccat
    10561 cgcggtgagc ccggacagga ccgccgacac gaggacgccg tgcacggccg tctgcgccgg
    10621 gtcggacttc tgccgtccgg tcagcagcca cagcagcccg gcgcccgcga acccgccgat
    10681 gcacgccgcg accaccacgg ccgtcggtga ccgccatccc gcgagcccga gcccggtggc
    10741 ggccacggcg ccgagcaccg cgcccggagt gacgccggtg acctcgggtc cggcaagcgg
    10801 gttgcgcagg gcggactgca ggaccgtgcc ggcgagtccg aggctcgcgc ccgcgacgag
    10861 cgccaccagc attctgggca gccggagtcg gagcaccaca tgacgtgcgg ccgggtcgcc
    10921 tgcaccaccg agcacctgcc acacgtcgtc ggcgccgagc gcccgccccg ccaccaggtc
    10981 ggcgcagccg acggcggcga ccagcagcgc ggacagggcg agcgtccggc gccgtacgag
    11041 gaaggaggtg acggctctca tgccgtggcc gcccttcttc tcatgagggc cactccggcc
    11101 ggtacgccga gcagtgccgt ccaggcgccc accggcgtct cgacgggcgc cagcgcgagc
    11161 cgggccggaa ggtccgcgca ggccacggcc acggcgcccc atgccgccga ccacggcagc
    11221 cagcgcaccg cgtcggcccg cgggctgagc cgccgggcca gatggggggc gaggaagccg
    11281 acccaggcca ccgggccgca cacggcgacg accggtgcga tgagcaggac ggagatcgcg
    11341 agcgcggcga gccgcgcgcg ccgcaccc
//
