LOCUS       NZ_BMWB01000001        10399 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces xantholiticus strain JCM 4863 sequence01, whole genome
            shotgun sequence.
ACCESSION   NZ_BMWB01000001
VERSION     NZ_BMWB01000001.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces xantholiticus
  ORGANISM  Streptomyces xantholiticus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 943286)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 114X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014651015.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:24:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,091
            CDSs (total)                      :: 7,016
            Genes (coding)                    :: 6,693
            CDSs (with protein)               :: 6,693
            Genes (RNA)                       :: 75
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 323
            CDSs (without protein)            :: 323
            Pseudo Genes (ambiguous residues) :: 0 of 323
            Pseudo Genes (frameshifted)       :: 187 of 323
            Pseudo Genes (incomplete)         :: 270 of 323
            Pseudo Genes (internal stop)      :: 13 of 323
            Pseudo Genes (multiple problems)  :: 140 of 323
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:39:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 531164
            Orig. end                         :: 541563
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMWB01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="4"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5399)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(386..399)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     misc_feature    597..612
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.94"
                     /tool="antismash"
     misc_feature    941..956
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            1046..1465
                     /locus_tag="IE198_RS02460"
                     /old_locus_tag="GCM10010381_05010"
     CDS             1046..1465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009997930.1"
                     /locus_tag="IE198_RS02460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05010"
                     /product="SsgA family sporulation/cell division regulator"
                     /protein_id="WP_189882075.1"
                     /transl_table=11
                     /translation="MSSTIEQSVRARLISDAPHSLAVPVVLCYSDTDPFAVRMAFPPEA
                     CLNDTGVTWTFARSLLDAGLRAPCGDGDVHIWPCGRVQTMIELRSPEGVALLQLDTASL
                     RRFLVRSYATVPAGNEAAAMDIERVLAALLGNARG"
     gene            1498..2310
                     /locus_tag="IE198_RS02465"
                     /old_locus_tag="GCM10010381_05020"
     CDS             1498..2310
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309419.1"
                     /locus_tag="IE198_RS02465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05020"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_189882077.1"
                     /transl_table=11
                     /translation="MTTAVSAGGVGPLLRRWREERRISQLELALRAGSSARHISFVETG
                     RSRPSEEMVLRLAEHLDVPVRERNSLLLAAGYAPRYTETPFGDPAMEALREGMERLLQG
                     YEPYPALVVDGTYNVLAANRGIAMLLEDLPEHLLAPPLNAMRITLHPEGLASRIRNLPE
                     WRGHLLQQMERQIAPARSDALRSLYDEVAAYPLPEGSGDERGVAAGEAPYPYFALPLRI
                     EHEGRVLSFVSSISTFNTPLDVTVAELAIETFLPADPATVKYLQSLTP"
     gene            complement(2300..2719)
                     /locus_tag="IE198_RS02470"
                     /old_locus_tag="GCM10010381_05030"
     CDS             complement(2300..2719)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309422.1"
                     /locus_tag="IE198_RS02470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05030"
                     /product="hypothetical protein"
                     /protein_id="WP_189882079.1"
                     /transl_table=11
                     /translation="MSTTLLAGISRTTEPQTMLRRFLAVDAVVTGANGLAYAAFSGPLG
                     RLLGVDATLLVGLGAFLAAYGLAVGLLAARARPPRAGVTLVVDANILWSLLSVAALGVW
                     LDPTAVGAAWTVLQALTVAGFAVLQWSALRATATA"
     gene            complement(2857..3896)
                     /locus_tag="IE198_RS02475"
                     /old_locus_tag="GCM10010381_05050"
                     /pseudo=""
     CDS             complement(2857..3896)
                     /NRPS_PKS="Domain: PKS_ER (16-209). E-value: 1.8e-23.
                     Score: 75.1. Matches aSDomain:
                     nrpspksdomains_IE198_RS02475_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006136274.1"
                     /locus_tag="IE198_RS02475"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05050"
                     /product="zinc-dependent alcohol dehydrogenase family
                     protein"
                     /pseudo=""
                     /sec_met_domain="ADH_N (E-value: 1.6e-32, bitscore: 107.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.8e-10, bitscore:
                     36.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVVFDDFGKRPEVREVPDPRPSRDGVVVKVEATGLCRSDWHGW
                     RGHDSGIALPHVPGHELAGTVHSVGDDVTRWSAGDRVTVPFICACGRCAACVRGAQQVC
                     ERQEQPGFTHWGSFAEYVPLRHADTNLVALPDAMAFTTAAGLGCRFATAFRAVVGQGRV
                     RPGEWVTVHGCGGVGLSAVMIAAACGARVVAVDVSPGALELARTFGAEICLDASTPGGG
                     EVAAALLTRPAAARTSRWMPWERR"
     aSDomain        complement(3270..3848)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE198_RS02475_PKS_ER.1"
                     /evalue="1.80E-23"
                     /label="IE198_RS02475_PKS_ER.1"
                     /locus_tag="IE198_RS02475"
                     /protein_end="209"
                     /protein_start="16"
                     /score="75.1"
                     /tool="antismash"
                     /translation="EVPDPRPSRDGVVVKVEATGLCRSDWHGWRGHDSGIALPHVPGHE
                     LAGTVHSVGDDVTRWSAGDRVTVPFICACGRCAACVRGAQQVCERQEQPGFTHWGSFAE
                     YVPLRHADTNLVALPDAMAFTTAAGLGCRFATAFRAVVGQGRVRPGEWVTVHGCGGVGL
                     SAVMIAAACGARVVAVDVSPGALELARTFG"
     CDS_motif       complement(3342..3398)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE198_RS02475_0001"
                     /evalue="1.60E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="IE198_RS02475"
                     /protein_end="185"
                     /protein_start="166"
                     /score="14.4"
                     /tool="antismash"
                     /translation="EWVTVHGCGGVGLSAVMIA"
     gene            complement(3954..4091)
                     /locus_tag="IE198_RS02480"
                     /old_locus_tag="GCM10010381_05060"
     CDS             complement(3954..4091)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE198_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010381_05060"
                     /product="hypothetical protein"
                     /protein_id="WP_189882852.1"
                     /transl_table=11
                     /translation="MAPGEPGRLVPGSVLAFAFSMWLVPGSGHAALYQGVPFLFAGVLV
                     "
     gene            complement(4155..4976)
                     /locus_tag="IE198_RS02485"
                     /old_locus_tag="GCM10010381_05070"
     CDS             complement(4155..4976)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="IE198_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05070"
                     /product="tyrosinase family protein"
                     /protein_id="WP_189882081.1"
                     /transl_table=11
                     /translation="MAVRKNQSTLTSTEKREFIDAVLGLKRSGRYDEFVRTHNAFIMGD
                     TDQGERVGHRSPSFLPWHRKFLLEFEQELQRIIPSVALPYWDWSTDRTPASSLWATDFL
                     GGDGRSRDGQVMAGPFANLAGNWSIDTQVDTRPFLRRALGGGGRALPTRADIEAVLAVE
                     TYDAPPWNSTSRGFRNLIEGWRGVNLHNRVHVWVGGHMATGASPNDPVFWLHHAFIDKL
                     WADWQTRHPASPYLPETPTENVVDLDSTMRPWNDVTPRDMLDHTRFYTFDT"
     misc_feature    complement(4527..4529)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5001..5399)
                     /locus_tag="IE198_RS02490"
                     /old_locus_tag="GCM10010381_05080"
     CDS             complement(5001..5399)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017995.5"
                     /locus_tag="IE198_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05080"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_189882083.1"
                     /sec_met_domain="melC (E-value: 1.2e-42, bitscore: 141.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTRRRFLRGGTAVLAAVAVAGTTASVLDEESARVNRTGQGRPPR
                     GEAGEPFDETYKGRRIQGWPTDHGHHGTGSGYRVLIDGTELHVMLNGDGTWVSLIDHYE
                     VFATPRALARSAVDNLAGADLVPRPAHR"
     misc_feature    complement(5878..5894)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.64"
                     /tool="antismash"
     misc_feature    5883..5897
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.1"
                     /tool="antismash"
     gene            5997..6425
                     /locus_tag="IE198_RS02495"
                     /old_locus_tag="GCM10010381_05090"
     CDS             5997..6425
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004935626.1"
                     /locus_tag="IE198_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05090"
                     /product="subtilase-type protease inhibitor"
                     /protein_id="WP_189882086.1"
                     /transl_table=11
                     /translation="MRRSVTKITCMAGLAAGVVALAAGPAAAGTHDSLYSPSAMVLTVG
                     QGESAATATVERAVTLHCRPTAGGTHPDAEAACADLERADGRPALTLNDDSDRACPQIY
                     APVTLTADGVWEGRRISYERTFANSCVAQSRVTNLLDF"
     gene            complement(6652..8829)
                     /locus_tag="IE198_RS02500"
                     /old_locus_tag="GCM10010381_05100"
     CDS             complement(6652..8829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965037.1"
                     /locus_tag="IE198_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05100"
                     /product="phage holin family protein"
                     /protein_id="WP_189882088.1"
                     /transl_table=11
                     /translation="MVEGRWRRAGSALLRVAVVWAVSTLTMLALAGLLPDFQLQSDDGD
                     SITRTAVTAGWGAGAFGLLTGLVWPVVVRALLLVPALVLGLLVFFLNGSLLLIALWLIP
                     DGRGTANPETAVVVAAVMSAVASATSTALAVRDDNAYRRRLSRLAHRRGRGRVAHDRSG
                     PPGTVFLQLDGVGYEALRGAVDSRVMPTVAGWVGATHRLTPWRTDWSSQTGASQLGILH
                     GSNHDVPAFRWYEKETRRIVVSNRPASAVELQRRAIEHTGDGGLLTVDGASRGNLFSGG
                     ADQLALVLSMAARRGRGNRSRAGYFAYFSDPANAVRTALSFVAEVGREVGQSTRARLRG
                     DTPRVGRGGLYPFIRAFATVVERDVVVAAVIGDMLAGRRAVYADLVAYDEVAHHSGPHS
                     SDAQAVLERLDRSIALISKVAEHTPRTYRIVLLSDHGQSPGETFEGAYGLTLKDLVRAG
                     CGLPVSRRAERSKSGAEARDAARDALRTALHRQPAGDGEEERPASGSDPIVLSSGNLAL
                     ISFPDVPYRMSCEEIRRRHPALLGTLANHPGIGFLLVRSEEHGSVVLGADGAEVPVDAL
                     KDDDGPLAGFGPGAADAVRRTDSFPHVADIMVNSMHDPRTGVVHAFEEQIGSHGGLGGE
                     QSQAFLLSPFELSRPVPAGVDLIGAEQVHHVLRRWLREGDGPQVPIGRVEVSRPDGEAQ
                     EQVPVGGGAAPDENPQSSRHRVHGRQCRRGP"
     gene            8945..9727
                     /locus_tag="IE198_RS02505"
                     /old_locus_tag="GCM10010381_05110"
     CDS             8945..9727
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965039.1"
                     /locus_tag="IE198_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05110"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_189882090.1"
                     /transl_table=11
                     /translation="MPVEVTWWGHATCTIEDSGVRVLTDPLFVRRLAHLRRRRGELPPR
                     QAAVADAVLVSHLHSDHLHLASLARLSPGTRLVVPRGAVRSVPGLGRLVRAAGLRVTEV
                     APGEKVRVRELLVRAVPAKHDGRRLPLGPHRSPALGFVVSGESHTYFAGDTGLFDSMAD
                     EVGPIDMALLPVGGWGPYLGHGHLDAVRAAQAAARLSPRAAVPVHYGTYWPIGMDAIRP
                     HEFYAPGDEFARKAAQLAPKVTVHRLGHCERIGPEGTR"
     gene            9724..10389
                     /locus_tag="IE198_RS02510"
                     /old_locus_tag="GCM10010381_05120"
     CDS             9724..10389
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309438.1"
                     /locus_tag="IE198_RS02510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010381_05120"
                     /product="DedA family protein"
                     /protein_id="WP_189882091.1"
                     /transl_table=11
                     /translation="MTAQLADALDRLSELVRQLPPESTQQAVGYPSLFLLVALGALVPV
                     VPTGAVVSSAAVVAFHQTAPLALLFVFLVASAAAFAGDVALYWLGGRGVRSRNGSRWLA
                     ALRERAAPDRLAQAQRGLDEHGVTVLVVSRLVPAGRVPIMLACLLARMPLRRFVRGDAP
                     ACLAWAATYGLIGILGGSLFAEPWQGVVAAVALTVLVSGVPALWRRLRPSRGSDGQHA"
ORIGIN
        1 cccggcggac ctggtcggcg ggcaccgcga cctggacacg gccgtacggg cggacggctg
       61 gccggcgcgt tcggcactgg ccgggaagtt cgtggtcgag ctgatcccgg gcacgctcga
      121 ggaggacaac ccgttcgact cactgtggac cgaccgcgag tacgcgacgc atctgcgcgg
      181 cctcgaggcg gcgggccgcc tcggcgaggc gggcgcgttc ccggcggtcc atcacgccgc
      241 ggccggtgac ccgcgcagcc ggtacgcgga cgcctcgatc cgcccgtggt tcgtcgtctt
      301 cgacggggac gcggcggcgt acgcgggcgg gtcgatcgac acgtcctggt acgaccggaa
      361 ccactacctc gtcgtcatga ccgccgcaca cagcgtggcg ccggcgatcg acggcacgaa
      421 cccgaccgag cagcaggccc gcgaccgcct ctcgctgctg gcgggtcggc acgcgagcgt
      481 ggtgtcggcc gactggtatc cgctgccgtc ggtgctgggc tcggtggtcg cacggggcgg
      541 gttgcagccg ggctcgtgac ctttgtccgg aaatcacctc ccggtaggtg accgtgggta
      601 acgcacatca cagcgggccc ctcggttcgc cggaacacca ccaagtggtt tatcgttcat
      661 ctacaagtgg gtgcgcacgg ggcagatgcc cccgggcctc accttttgcc ctaggcgacc
      721 gccgctcgcg cccacgccct gtgaccgccc cggccggaaa cccccgtccg gccggggcat
      781 cccctctttt ccggcctgtc gccacccgtc ccgggcggcg atgcggcgac tcaaccgcaa
      841 cgctttgcgg ctacccgtcc gtaaccagcc agctgtccca tttacgggga aatgcgttgg
      901 cgcaaaagcc tagccatcct ggcgcaatcg tttcagtctt ggtgatgcag gtcacacgcg
      961 ccactggcgt cgctcaccca ggcctctgcc tgcccgcgac gtacgagcac gagagcggaa
     1021 ccgcacagca gcagaggagc gagcgatgtc atcgaccatc gagcaatccg tacgggcccg
     1081 cctcatcagc gatgcgcccc actccctggc cgtgccggtg gttctgtgtt acagcgacac
     1141 cgacccgttc gccgtccgca tggccttccc gccggaggcc tgtctgaacg acaccggcgt
     1201 gacctggacc tttgcccgca gtctgctcga cgcggggttg cgcgcgccgt gcggggacgg
     1261 ggatgtgcac atctggccct gcgggcgggt gcagaccatg atcgaactgc gttcgccgga
     1321 aggggtcgcg ctgctccagc tcgacaccgc gagcctgcgc cgcttcctgg tccggtcgta
     1381 cgcgaccgtg ccggccggca acgaagcggc cgccatggac atcgagcggg tgctcgctgc
     1441 cctgctgggc aacgcacggg gctgagacgg gggaccgggt cgtaatacgg tctggctatg
     1501 acaactgccg tttccgccgg cggggtgggt ccgctgctgc gccgctggcg cgaggagcgc
     1561 cggatcagcc agctcgaact cgccctgcgc gccggctcct cggcccggca catcagtttc
     1621 gtcgagaccg gccgttcgcg ccccagcgag gagatggtcc tgcgtctcgc cgagcacctc
     1681 gacgtccccg tgagggagcg caactcgctg ctgctggccg ccggttacgc gccccgttac
     1741 accgagacgc cgtttggcga cccggcgatg gaggcgctgc gcgagggcat ggagcgactg
     1801 ctgcagggct acgagcccta ccccgcgctg gtcgtcgacg gcacgtacaa cgtgctcgcc
     1861 gccaaccggg gcatcgcgat gctgctcgag gacctgccgg agcatctgct cgccccgccg
     1921 ttgaacgcca tgcggatcac cctccacccc gagggcctcg cgtccaggat ccgcaatctg
     1981 ccggagtggc gcggccatct gctgcagcag atggaacggc agatcgcgcc ggcccgctcc
     2041 gacgcgctgc gcagcctgta cgacgaggtc gcggcctatc cgctgcccga gggcagcggt
     2101 gacgagcggg gcgtggcagc gggcgaggcg ccgtatccgt acttcgcact gccgctgcgg
     2161 atcgagcacg agggccgcgt gctctccttc gtgtcgtcga tctccacgtt caacacgccc
     2221 ttggacgtga ccgtcgccga gctggccatc gagacgttcc tgccggccga cccggcgacg
     2281 gtgaagtacc tgcagtcgct cacgccgtag cggtggcgcg cagggccgac cactgcagga
     2341 cggcgaatcc ggcgacggtc agcgcctgga gcacggtcca ggcggcgccg acggcggtcg
     2401 ggtcgagcca cacgccgagg gcggcgacgc tgaggaggga ccacaggatg ttggcgtcga
     2461 cgacgagcgt gacaccggcc cgcggcggcc ttgcgcgggc ggcgaggagg ccgacggcca
     2521 ggccgtaggc cgcgaggaag gcaccgaggc cgaccagcag cgtggcgtcc acaccgagca
     2581 gccgccccag cggcccagaa aaggccgcgt acgccaggcc gttggcaccg gtgacgacgg
     2641 cgtcgacggc gaggaagcgg cgcagcatgg tctgcggctc cgtggtgcgg gagattccgg
     2701 caagcagggt cgtggacatg gcggatcagc ctccgtcgag ggttgggcgg gccggtcgtg
     2761 ggcccggagc ccggacggag tgcgtcgccc gggtcccggt gctcacagac tgccgtgccg
     2821 ccctcggggg gtcgattacg cctgaggtaa tggccttcag atgcccgggg tgatcacggt
     2881 gaccccggtg ccgggggcgg tgccgagtgc cacaagggcc tccggcacgt cgaccaggcc
     2941 gatctccttg gtgaccagca gatccggccg cagcgccccg gaggcgacca tggccatcat
     3001 ctccgggtag gcgtgggcgg ccatgccgtg gctgcccagg atctccagtt cgagggcgac
     3061 gacccggtcc atgggcagat ggaccccgtc cgggagcagg cccacctgca cgtggcggcc
     3121 ctgcccgcgc aggctctgta cggagttcgc acaggtcacc ggcgctccca gggcatccag
     3181 cgagaggtgc gcgccgccgc cggtcgcgtc aggagggctg ctgcgacctc gcccccgccc
     3241 ggcgtcgagg cgtccaggca gatctccgcg ccgaaggtac gggccagctc cagcgccccc
     3301 ggcgagacgt ccacggcgac gacccgggcc ccgcaggcgg cggcgatcat caccgcggag
     3361 aggccgaccc cgccgcatcc atgcacggtg acccactccc ccggccgcac ccgtccctgg
     3421 ccgacgacgg cgcggaacgc ggtggcgaag cggcagccga ggccggcggc ggtggtgaac
     3481 gccatggcgt ccggcagcgc caccagattg gtgtcggcgt ggcgcagggg gacgtactcg
     3541 gcgaaggagc cccagtgggt gaaaccgggc tgctcctggc gttcgcacac ctgctgggcg
     3601 ccgcggacgc acgcggcgca ccggccgcag gcgcagatga acggcaccgt gacccggtcg
     3661 ccggcgctcc agcgggtcac gtcgtcgccc accgagtgga cggtgcccgc cagttcgtgg
     3721 ccggggacgt gcggcagggc gatgccggag tcgtggcccc tccagccgtg ccagtcgctg
     3781 cggcacagcc cggttgcctc gaccttgacc acgacaccgt cgcgcgacgg ccgggggtcg
     3841 gggacctccc gtacctcggg ccgctttccg aagtcgtcga acaccaccgc gcgcacgtac
     3901 cactctcctt gttcctgggc ggccgttccg atcctgcggg tcggcgccca ggcctacacc
     3961 aggacaccgg cgaagaggaa gggcacgccc tggtacaagg ccgcgtggcc ggaaccgggg
     4021 accagccaca tggagaacgc gaaggcgagg accgagccgg gcacgaggcg gcccggttca
     4081 cccggtgcca ctggccgggg acacccggtg gtggacagcc cggccgcctc cggtcgcggc
     4141 acctggcttc gggctcaggt gtcgaatgtg tagaaccgtg tgtggtccaa catgtctcgt
     4201 ggcgtgacgt cgttccaggg gcgcatggtg gagtccagat ccaccacgtt ttcggtcggg
     4261 gtttccggca gatacggcga tgcgggatgc cgtgtctgcc agtccgccca cagtttgtct
     4321 atgaaggcgt ggtgcagcca gaaaacggga tcgttcgggg aggcgcccgt tgccatgtgg
     4381 ccgcccaccc agacgtgcac ccggttgtgc aggttgacgc ctcgccagcc ctcgatgagg
     4441 tttcgaaaac cccgcgaggt gctgttccac ggcggtgcgt cgtatgtttc cactgccaga
     4501 accgcctcga tgtcggcgcg tgtgggtaat gcccttcctc cgccacccaa tgcacgccgc
     4561 aggaaggggc gcgtgtccac ttgggtgtcg atggaccaat ttccggccag gttcgcgaag
     4621 ggcccggcca tcacctgtcc gtcgcggctg cgtccgtcgc cgcccaggaa atcggtggcc
     4681 cacagggagg acgcgggcgt acggtccgtg ctccaatccc agtagggcag tgccacggag
     4741 gggatgattc gttggagttc ctgctcgaat tcgagcagga acttccggtg ccagggcaga
     4801 aaggacggag atcggtgtcc gacccgttct ccttgatccg tatcacccat gatgaatgcg
     4861 ttgtgcgtgc gcacgaattc gtcataacga ccgctgcgtt tgagtccgag gactgcatcg
     4921 atgaattcgc gcttctcggt ggaggtgagc gtggactggt tttttcgcac ggccatgtca
     4981 ggcgcccctt tcctggatgc tcaccgatgt gccgggcgag ggacgaggtc ggcgccggcg
     5041 agattgtcga ctgccgaccg tgcgagggca cgcggagtcg cgaaaacctc gtagtgatcg
     5101 atgagactga cccacgtccc gtctccgttc agcatgacgt ggagctcggt cccgtctatc
     5161 agaacgcggt agccgctccc cgtcccgtga tgtccgtgat cagtcggcca tccctggata
     5221 cgcctgccct tgtatgtctc gtcgaacggc tcgccggcct cgccacgggg cggacggccc
     5281 tgccctgtcc ggttcacccg ggcggattct tcgtcgagga cagaagcggt tgttccggcg
     5341 acggccaccg ccgcaagcac ggcagttcct cctcgaagaa accgacggcg agtacgcatt
     5401 gtctttcctc tctgcaatgc agccgaccat tcgcgctgtt gacggttcac agccgactgc
     5461 cccggatcac atcaacgttg cctaaagaat ttgcgcgggc cgcccacatg gcggatatct
     5521 ggacaacagt tgcatgaagg agcaactttg cagcgaagtg gatcgtcctg cgggaccgga
     5581 cgacagggcg tcccgtgcag gaaatccttg agccgctcac ccggtgctgc gggagatttt
     5641 tcaccgatca agggcgcctg accgccgtca gaggcgcgac agcttgacgc aaaaaccacg
     5701 cccaagggat ttttatatgc cgcttcaaca accttccttc gacatcgagc gtaaaggttg
     5761 catatcggtc gaggcgtcac gactcattaa cggccctgag gtcgtcccac ccggtgtgag
     5821 tccaatctga cgaactgcgg cgaagcctgc ggaaaagaat gcttcgaccc cgggtcatgc
     5881 ctatttttcg gccaattaca accgtcgccg atgtccgaag caggggtcat cgatgtgaat
     5941 tctcgggacg cctgagcaac gctgcaggtt ccgtagtcga gaaaaaggag aatccgatgc
     6001 gtcgctcagt taccaagatc acctgcatgg cggggttggc cgccggcgtc gtcgctctgg
     6061 cagccggccc tgccgccgcc ggcacgcacg acagcctgta ctcgccctcc gccatggtgc
     6121 tgacggtcgg tcagggcgag agcgcggcaa cagcgaccgt cgaacgggcg gtcaccctgc
     6181 actgcaggcc gaccgccggc ggaacccacc cggacgccga ggccgcatgc gcggacctcg
     6241 aacgcgccga cggccggccc gcgctcacgc tgaacgacga ttcggatcgt gcgtgcccgc
     6301 agatctacgc tcccgtcacc ctcaccgctg acggggtgtg ggagggccgc cgaatctcgt
     6361 acgagcgcac gttcgccaac agctgcgtgg cgcagtcccg ggtcacgaat ctgctcgact
     6421 tctgacatcg gcaacccccg gcacgccggg atggtggtcc gaccccacgg ggccggacca
     6481 cgatccttgt ctctgccctg cgcctcggcg acctccgtgg cgcggcgact gacgagcgac
     6541 acgttgccga agccgtggcg cgtccagggt gtgcagcggc cgcggggagc ggcagggcgt
     6601 cggaggcgca ctgaccagcg tccggccagt ggcacggccg acgtcgcggg gtcacgggcc
     6661 tcgtcggcac tgacggccgt ggacccgatg ccgagacgac tgaggatttt cgtccggcgc
     6721 ggcaccacca ccgaccggaa cctgttcctg cgcttcaccg tccggtcggg aaacctcaac
     6781 ccgcccgatc ggcacctgcg gcccgtcccc ctcccgcagc cagcgccgca gcacgtggtg
     6841 cacctgttcc gcgccgatca ggtcgacgcc cgcggggacc ggccgcgaga gctcgaacgg
     6901 cgacagcaga aaggcctgcg actgctcccc gccgagcccg ccgtgcgaac cgatctgctc
     6961 ctcgaaggcg tgcaccacac cggtcctcgg gtcgtgcatc gagttgacca tgatgtcggc
     7021 gacatgcggg aacgagtcgg tacgacgtac ggcgtcggcc gcgccgggac cgaaaccggc
     7081 cagcggcccg tcatcgtcct tcagcgcgtc tacgggcacc tccgcaccgt cggcgccgag
     7141 caccaccgag ccgtgctcct cgctgcgcac cagcagaaaa ccgatcccgg gatggttcgc
     7201 gagcgtgccg agcagcgccg ggtggcggcg ccggatctcc tcgcaactca tgcggtaggg
     7261 cacgtcgggg aacgagatca gggccaggtt cccggaggac agcacgatcg ggtcggagcc
     7321 cgacgcgggc cgttcctcct caccgtcgcc ggccggctgc cggtgcagcg cggtccgcag
     7381 ggcgtcgcgc gccgcgtcgc gggcctccgc accgctcttc gaacgctcgg cccgccggga
     7441 caccggcagc ccgcaccccg cgcgcaccag gtccttcagc gtgagcccgt aggctccttc
     7501 gaaggtctcc cccgggctct gcccgtggtc ggagagcagc acgatccggt aggtgcgggg
     7561 cgtgtgctcg gcgaccttgg agatcagcgc gatggagcgg tccagacgct ccagcaccgc
     7621 ctgcgcgtcc gagctgtgcg gccccgagtg gtgcgccacc tcgtcgtagg cgaccaggtc
     7681 ggcgtagacc gcccttcgcc cggcgagcat gtcccctatc accgcggcga cgaccacatc
     7741 gcgctcgacg accgtcgcga acgcccggat gaacgggtag agcccgccgc ggcccacccg
     7801 cggcgtgtcc ccgcggagcc tggcccgggt cgactgcccg acctcgcgcc cgacctcggc
     7861 gacgaaggac agcgcggtac ggacggcgtt ggcgggatcg gagaagtacg cgaagtaacc
     7921 ggcccgggag cggttccccc tgccgcgcct ggccgccatg gacagcacca gcgccaactg
     7981 gtcggcgccg ccgctgaaga ggtttccccg gctcgcgccg tccaccgtga gcaggccgcc
     8041 gtccccggtg tgctcgatgg cccgccgctg cagttccacg gcgctcgccg ggcggttgct
     8101 gacgacgatc cggcgggttt ccttctcgta ccagcgaaag gcgggcacgt cgtggttgga
     8161 gccgtgcagg atgccgagct ggctggcgcc ggtctggctg gaccagtcgg tgcgccacgg
     8221 ggtgagccgg tgtgtggcgc cgacccatcc ggcgacggtc ggcatcaccc tgctgtccac
     8281 ggcgccgcgc agcgcctcgt acccgacgcc gtcgagttgc aggaagaccg tgccgggcgg
     8341 tcccgaacgg tcgtgggcaa ccctcccgcg tccgcggcgg tgggcgagcc gggaaagtct
     8401 tctgcggtag gcgttgtcgt cgcggaccgc gagcgccgtc gaggtggcgg aggcgaccgc
     8461 ggacatcacg gcggccacca ccaccgcggt ctccgggttg gccgtgccgc gtccgtcggg
     8521 gatgagccac agggcgatca acagcagcga gccgttgagg aagaacacca gcaggcccag
     8581 taccagggcc ggtacgagca gcagcgcccg tacgaccacg ggccagacca ggcccgtgag
     8641 caggccgaac gcccccgcgc cccagcccgc cgtgaccgcg gtccgggtga tgctgtcgcc
     8701 gtcgtccgac tggagctgga agtccggcag cagtccggcg agcgccagca tcgtcagcgt
     8761 cgacaccgcc cacacgacgg ccacgcgcag cagagcgctg ccggcccggc gccaccgccc
     8821 ttcgaccacg cttcgttcac ctcacctcgg aaccggtctc cagcgtggca cagagcccgg
     8881 cccgcccgga cgggcgaagg cctaggctcg tacggtacgg ggatcgacag cgaggaggcg
     8941 tcgcgtgccg gtggaggtca cctggtgggg tcatgccacc tgcacgatcg aggactccgg
     9001 ggtgcgggtg ctgaccgacc cgttgttcgt gcggcgcctc gcccatctgc ggcggcgccg
     9061 cggtgaactg ccgccccggc aggcggccgt cgccgacgcc gtcctcgtct cccatctgca
     9121 ctccgaccat ctgcacctgg cgtcgctcgc gcggctctct cccggcaccc ggctggtcgt
     9181 gccgcgcggc gcggtacgtt cggtgccggg gctcggccgg ctggtacgcg cggccgggct
     9241 gcgggtcacg gaggtcgcgc cgggcgagaa ggtccgggtg cgcgagctgc tcgtacgggc
     9301 cgtgcccgcc aagcacgacg ggcggcggct gccgctcgga ccgcaccgct caccggccct
     9361 cggcttcgtc gtcagcggcg agtcccacac gtacttcgcg ggcgacaccg gcctgttcga
     9421 ctcgatggcc gacgaggtcg gcccgatcga catggcgctg ctgcccgtcg gcggctgggg
     9481 cccgtacctg ggccacggcc atctggacgc cgttcgcgcg gcgcaggcag cggcccggct
     9541 ctcgccgcgg gccgccgtac cggtgcacta cggcacgtac tggccgatcg ggatggacgc
     9601 gatcagaccg cacgagttct acgcgcccgg cgacgagttc gcgcgcaagg cggcgcaact
     9661 ggcaccgaag gtgacagtgc accggctcgg gcactgcgag cggatcgggc cggaggggac
     9721 caggtgacgg cacagctcgc cgacgcgctc gaccggttgt ccgagctggt gcggcaactt
     9781 cctccggagt cgacccagca ggccgtgggc tatccgtccc tgttcctgct ggtggctctc
     9841 ggagcgctgg tgccagtggt gcccaccggc gccgtggtca gttcggccgc cgtggtcgcc
     9901 ttccaccaga ccgcaccgct cgcgctgctg ttcgtcttcc tcgtcgcgtc ggcggccgcg
     9961 ttcgccggtg atgtggccct ctactggctg ggagggcgcg gggtccggtc gaggaacggt
    10021 tcgcgctggc tcgccgccct gcgcgaacgc gccgcgccgg accggctcgc gcaggcccag
    10081 cgagggctcg acgagcacgg ggtgacggtg ctggtggtct cccggctggt gcccgccggg
    10141 agggtgccga tcatgctggc gtgcctgctg gccaggatgc cgctgcgtcg cttcgtccgc
    10201 ggtgacgcgc ccgcctgcct ggcgtgggcc gcgacgtacg gcctgatcgg catcctgggc
    10261 gggtcgctgt tcgcggagcc gtggcagggc gtcgtcgcgg cggtcgccct gacggtgctc
    10321 gtcagcggcg tgccggcgct gtggcgcagg ctccgcccgt cccgcggctc agacggtcag
    10381 cacgcgtgac ccgccgacc
//
