LOCUS       NZ_BMVW01000030        11383 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence30, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000030
VERSION     NZ_BMVW01000030.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 44713)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 22671
            Orig. end                         :: 34054
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11383
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11383
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11383
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6383](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6383
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            516..1523
                     /locus_tag="IE242_RS36675"
                     /old_locus_tag="GCM10010365_75200"
     CDS             516..1523
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947329.1"
                     /locus_tag="IE242_RS36675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75200"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_189867291.1"
                     /transl_table=11
                     /translation="MSRRFAALAALAVVCAGVELVAGRGMSPAVVWDVLGGGGDATERH
                     IFLQLRLPRLLVALGAGACLAVAGLVLQSALRNPLAGPEVTGVTPGAVLGAVTATALGL
                     AGWDSPLAVVLAACAGGCAGAALLWLLAGRGGGDAAQTAVHGVLVSAVLGGLTAMVLLV
                     EPGELGSVVQWLVGTTEGRVWQHWHLLWPWALAWGAAAWLLAGPLTLLRCGDDIALAAG
                     LSARRARTLALLCAVALTAGAVAAVGALGFVGLLAPHLAVALFGADLRASLPGAALVGA
                     VVVCGADAAAQLSSRLLAEVLGSGRLTLPVGALTACLGAALLLVVVRRTPSRTF"
     gene            1544..2365
                     /locus_tag="IE242_RS36680"
                     /old_locus_tag="GCM10010365_75210"
     CDS             1544..2365
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004114.1"
                     /locus_tag="IE242_RS36680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75210"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189867293.1"
                     /transl_table=11
                     /translation="MTESMGIHVEGVRFGYPARPVLRGVDMTVRPGELTALIGLNGCGK
                     STLLRLAAGLLRPDRGRVLLGGDDLARLSRRAAARRVALLHQSAPAVPGMTVRHLVRQG
                     RYAARGPLGMLREGDDPVVHRALRDVGVEQWADRDVDALSGGERQRVRLAMALAQDTRI
                     LLLDEPTTYLDLHHQLDVLQTVVRLREERGLTVVMVLHDLAHAARFAERIVALRDGRVV
                     ADGTPKEVVTPGLLADVLKVAGRVGRDPESGWPVCYPDHPLADLEYENQIH"
     gene            2423..2536
                     /gene="amiA"
                     /locus_tag="IE242_RS38745"
     CDS             2423..2536
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004115.1"
                     /locus_tag="IE242_RS38745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240661371.1"
                     /transl_table=11
                     /translation="MDNEQVFAPIADPGQLAHDSASHSNALVENPFDDTEE"
     gene            2630..3517
                     /locus_tag="IE242_RS36685"
                     /old_locus_tag="GCM10010365_75220"
     CDS             2630..3517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613004.1"
                     /locus_tag="IE242_RS36685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75220"
                     /product="hypothetical protein"
                     /protein_id="WP_189867295.1"
                     /transl_table=11
                     /translation="MSRSQLAPGVEVVAVPGRDLAVRTAEGEFLSVRTQDADKDALLSR
                     LAGATTAPADDELHRVVRAFEQAGYLTDEPQHPEWPAARRGIRLLGDPVLTEPLAAHLA
                     ALGAVPHTTSAAPAPEASPRDLDDLLHEDPAAVVWCLDGPVPDGLWDAADMLPERGVAW
                     LRCHREGWQAYVEPLAAAPGDVTSAHIRARRLAATPAHRELAAYWSGPRTSGAPVRLTV
                     PAAGLLAALLADDLRRWAIDAPDAPGSGGLPARRRLRRVDLRTLTVTEHPVLPVPEAAT
                     MPKTKPKTKPKKDG"
     gene            3514..5004
                     /locus_tag="IE242_RS36690"
                     /old_locus_tag="GCM10010365_75230"
     CDS             3514..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048304.1"
                     /locus_tag="IE242_RS36690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75230"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_189867297.1"
                     /transl_table=11
                     /translation="MTPFSEAVEGLATDVHLPDGDGPFPTVLVRTPYDRARYRAEARGW
                     ARHGFAAAVQDVRGRFASPGEWHPYQNEAADGAATVRWIRRQPWSDGRIVAVGASYAAH
                     CALVLAFDAPGGARPDAVVAAVPALGAAETAREPSGVERLLTRAGWWAAHGDRRDSDES
                     ALDKALAADPGLLTHLPLTGLPERLGRSLPSWAALWRHRERGRLVSRVAHADVPLLAVG
                     GHHDHFTEDTVELWRAWGGPSARLLLGPWGHGLVTAPGPDAGPAHRVSLGELYVRWVRR
                     ALAGELAQGRHGAVALGGGNLWLPADAHGEPRTQRLRLLHGSAFTADPDRPVRSDDLTV
                     PTVPTGGPPDRCVLVTPPLPRPLDVVGPVRVRLRATAHTPSADWAARLVALTPEGRAEG
                     LAVGVVRREEPAGRETELTVELGRLARRLPAGSRLRLEIAGHHFPAHARNPHTGDDPVT
                     ADRLIPSGRAVDPRSVALRLPVLTSRPTPTDPAKEILR"
     gene            5001..6383
                     /locus_tag="IE242_RS36695"
                     /old_locus_tag="GCM10010365_75240"
     CDS             5001..6383
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="IE242_RS36695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75240"
                     /product="YcaO-like family protein"
                     /protein_id="WP_189867299.1"
                     /sec_met_domain="YcaO (E-value: 4.2e-51, bitscore: 166.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALLPLEALVDPVCGIVRKVKPVEHPVGAPPRYTALTAEISDAR
                     RLGLWPADRVSLGTTFGDPGQARVAAIAEGVERYCGNRVPPPGHPDAPLRATAAELAEK
                     GLRLYGPDDLPAYAQWQYDREKFPYRPLTADTPALWTRGAERLPDGTTTEVWAPVALTH
                     LNWRQGELRSLPRTHHLNYAGIATGQGLDDAAERGLLEIVERDALELWWHLDGPARGID
                     PASVPGLADDLAGSALDVHLVEMPSEFAPCMAALVHDPRLGLYAAGFACKYDPAEAARK
                     AVLEAVHTWVFTQGLTDPDGWVFQAVEAGLLARGLYLEHRADGRYLDACGEQFEHVRDL
                     GAHVQVWLDERMAPEARRFTGPALGTVSLDAVRPGSRDRLERALHAGGHRVMTFDLTTE
                     DVAETPLRVARVLVSGLLPNAPAAFGYFGCPRLAETAVARGWRAGAPGAPEDFTLAPPP
                     HM"
     gene            6422..7546
                     /locus_tag="IE242_RS36700"
                     /old_locus_tag="GCM10010365_75250"
     CDS             6422..7546
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048308.1"
                     /locus_tag="IE242_RS36700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75250"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_189867301.1"
                     /transl_table=11
                     /translation="MNLVAALARARSPERPGPDTPAGPAVRAWPGPSRPVPEAGRQDLD
                     LRALLRLSLAASDDSGRLRPASSAGALHPVDTELVVGAGCSLPPGRYGYDPLKHHVHRL
                     GRQPDGTPPGVTAELSVTARRTVSHYGHRAWPLLLLDTGHAAAALFLAARALGAGEPEV
                     RLDGLAESPLAAVRIASPGGQVPGRPLDGTHRPQPPAGVPTAAELLARRSDPPPLPGTP
                     PPDALRAVLATAARASAGELRWCVAVGAPRPGLLELAADGTTLRRRAVGEARPTLAAWA
                     AGQAWIAEAGAVLLAHGCPADADAPHIRRTHLRAGFTVHLAHVTARRHGLGARPVGSWQ
                     QADLGAALGAAPGRDWIVHGLALGTRHADEENTT"
     gene            7543..9282
                     /locus_tag="IE242_RS36705"
                     /old_locus_tag="GCM10010365_75260"
     CDS             7543..9282
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="IE242_RS36705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75260"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_189867310.1"
                     /transl_table=11
                     /translation="MIVHPELRRAARRARRPLLTATLLQGTVTLTHLAQAALLAVALAD
                     LARGDTGRLPWLLAAVLAVVAARAGLAMGQRRTATRAGAQVRVALRDEFLAHLGRLGPA
                     HLTSARAGAVRTTLVDGVEGVDAYVSRYLPQLLITVTLPPLVLAVLAAVEPRALLGLVP
                     ALLLALCGPRVWDRLLAARGKEHWDTYEGLGADYLEALQGMPALRAAGAVGRTRARLEE
                     RSAALHRATVAKLRVSLVDTGITDLAVQGGTAAAALLACWSAVTGSTTATGTYLVLLLA
                     SECFRPVRDLAREWHAGYLGVSAADGLAALRTAEPAVRDTGTAPAHWAAPPELRFEDVG
                     FTYDGAPAPALHHVSFTAEAGRTTAIVGPSGAGKSTLLALLLRHHDPQEGRITLDGRRT
                     TEYALDSLRQGIAVVSQETYLFHATIADNLRLARPDATDDDLTRATRIAGVHAEIAALP
                     DGYATVLGERGATLSGGQRQRLALARALLADAPVLVLDEATSSVDERREADIVRELSKA
                     ASGRTVLVVAHRLAAVRHADRIVVLDAGRVDAVGEHTGLAEAGSVYTRLVEAGHVHREG
                     APA"
     gene            9279..11036
                     /locus_tag="IE242_RS36710"
                     /old_locus_tag="GCM10010365_75270"
     CDS             9279..11036
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328331.1"
                     /locus_tag="IE242_RS36710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_75270"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189867312.1"
                     /transl_table=11
                     /translation="MSSAADTATIDAGVPARGSLRALLPALAGHRAMTVRTCAAALLEQ
                     GSLVTLLTLAAHTVGTAVLEGHAPSAATVTALVTLVLLRALMTWREMDLSHDLAYRVLA
                     VLRVRVFDGLARSAPARVAGRRSGDLAATAMADVEALEFFYAHTTAQLLAAGTVFTGGT
                     AVLATVEPWLLAAVLPVAVLLAAAPFADARGRAARGSRTRTAVARLSADTVDTVDGLRE
                     LLACGALAERRRRLAERGRQVGDAQRAEAVWEAVAAAVRDLLIVVAVLGVVAAAAQSVN
                     AGRLHGAWAPAAMALALAVLGPVAESARSLSQAVSLRAAAARVGAAVKAPALAPPPAAP
                     RSLPSGPLGVRLHRVRFDYGGGPVLDGVELTVPAGQTLALVGASGAGKSTCAHLLARFW
                     DPSEGAVQLVPADGEPVDVREVSDAELRRAVALVGQESPLFHGTLAENLRLAAPEADDD
                     LLTETARLCGVDRIAPMDTPVGERGSTLSGGQRARIALARALLARPRVLVLDESTAHLD
                     NASDARLAAALKQEDRTTVVIAHRRATIRRADRIAVLEAGRIAEEGTWEELTGRPDSAL
                     NRSLAHIPS"
     gene            11077..11214
                     /locus_tag="IE242_RS36715"
     CDS             11077..11214
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS36715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_189867314.1"
                     /transl_table=11
                     /translation="MSNVRLCRSFQATSTGSINDHCSSGRGLGHGFRSLTPPLRQDTVH
                     "
ORIGIN
        1 gacgtcgcgg gcctgtggcc gtggctgctc gtcgcggcgc ccgccctcgt actgtgcgcg
       61 ccggtgctct cggtgatgcg gctgggcgac gaggacgccg aggcgctggg cgtgcgcgcc
      121 cagcgggccc ggctggccgc gctggccatc gccgtggtgc tgatcgcgcc cgtgacggcg
      181 gtgtgcgggc ccgtggcgtg ggtgggcttc ctcgccccgc acctggctcg gtggttcaac
      241 cccgcggcgg gggcggtgcg gtggctgtcc tggtccgccg cgtggggtgc tgtcgtcgtc
      301 accgtcgccg atgtgccggc ccggctggcg ctggcgcccg tggagacgcc ggtcggggcc
      361 tggacggcct tgctgggggt gccggccggg gtcgccctga tgcgggcggg cggccgtggc
      421 cgtggcctcg gccgagtccg gcgcgggacg gcgggttccg gacccggcgg ggtttccctt
      481 cgccccggtg aagcgaccgg aacggaggac gcgcgatgag ccggcgtttc gcggcgctcg
      541 cggccctggc cgtcgtctgc gccggagtgg aactggtggc cgggcgcggc atgtccccgg
      601 ccgtggtctg ggacgtcctg ggcggtggcg gtgacgcgac ggaacgtcac atcttcctgc
      661 aactgcgcct gcccagactg ctggtggccc tcggagcggg cgcgtgcctc gccgtggcgg
      721 gactggtcct gcagtccgcg ctgcgcaatc ccctcgccgg gcccgaggtg acgggcgtga
      781 cgccgggggc ggtcctcggg gccgtcaccg cgacagccct gggactcgcc ggctgggact
      841 cgcccctggc cgtcgtcctc gccgcctgcg cgggcggctg cgccggagcg gcgctgctct
      901 ggctgctcgc cggccgtggt ggtggcgatg ccgcgcagac cgccgtgcac ggggtgctgg
      961 tgtcggcggt gctcggcggg ctcaccgcca tggtgctcct cgtggagccg ggcgaactcg
     1021 gcagcgtcgt ccagtggctc gtcggcacga ccgaggggcg ggtgtggcag cactggcacc
     1081 tgctgtggcc gtgggcgctg gcctgggggg ccgcggcctg gctgctggcc gggccgctga
     1141 ccctgctgcg ctgcggggac gacatcgccc tcgccgccgg cctctccgcc cggcgggccc
     1201 ggaccctcgc cctgctgtgc gcggtggcac tgacggcggg cgcggtggcc gccgtcgggg
     1261 cgctgggctt cgtggggctg ctggccccgc atctggccgt cgccctcttc ggcgcggacc
     1321 tgcgggcgag ccttcccggc gccgccctgg tgggcgcggt cgtggtgtgc ggggcggacg
     1381 ccgcggcgca gctgtcctcg cggctgctgg cggaagtgct gggctccggc cggctcacgc
     1441 tgccggtcgg ggcgctcacc gcctgcctcg gcgccgcgct gctgctggtc gtcgtgcgcc
     1501 gcacgccgag ccgtacgttc tgaagtccga cggaggacga agcatgaccg agtccatggg
     1561 gattcacgtc gagggggtcc ggtttggcta ccccgcacgc cccgtgctga ggggcgtcga
     1621 catgaccgtc cggccgggcg aactgaccgc cctcatcggc ctcaacggct gcggcaagtc
     1681 gaccctgctg cgcctggccg ccgggctgct gagaccggac cgggggcgcg tactgctcgg
     1741 cggggacgac ctcgcccggc tctcccggcg cgccgcggcg cgaagggtgg cgctgctgca
     1801 ccagtccgcg cccgccgtac cgggcatgac ggtgcgccat ctggtgcggc aggggcggta
     1861 cgcggcacgt ggcccgctgg gcatgctgcg cgagggcgac gaccccgtcg tgcaccgggc
     1921 gctgcgcgac gtcggtgtgg agcagtgggc cgaccgtgac gtcgacgcgc tgtccggcgg
     1981 cgagcggcag cgggtgcggc tcgcgatggc gctggcccag gacacccgca tcctgctgct
     2041 cgacgagccg accacctatc tggacctgca ccaccagctc gacgtgctgc agacggtggt
     2101 ccgcctgcgc gaggagcgcg gactcaccgt ggtgatggtg ctgcacgacc tggcccacgc
     2161 ggcccgtttc gccgagcgga tcgtcgcgct gcgggacggc cgtgtggtgg ccgacgggac
     2221 gccaaaggag gtcgtcacgc cgggactgct ggccgatgtg ctgaaggtgg cgggccgggt
     2281 cggccgggat ccggagagcg gatggccggt gtgttaccca gatcaccccc tcgccgatct
     2341 agaatatgaa aatcagattc attagtgtgg gggtgcggtg ctcacccgat cgccgcatct
     2401 ccctggtgaa taaggagagt tcatggacaa cgagcaggtc ttcgcgccga tcgccgaccc
     2461 gggtcagctg gcccacgact cggcctccca ctccaacgcg ctcgtcgaga accccttcga
     2521 cgacaccgag gagtaggcga ggggtcagcc cttcagaccg tgggcccgcc cgttgccttc
     2581 cgggcgggcc cacgcccgtt ccacgtcctg ccgtcccagg agggtcactg tgtcccgcag
     2641 ccagctcgca cccggtgtcg aggtcgtcgc cgtacccggg cgggatcttg ccgtccgtac
     2701 cgccgaaggg gagttcctca gcgtcaggac acaggacgcc gacaaggacg ccctgctgtc
     2761 ccggctcgcg ggcgcgacca cggccccggc ggacgacgaa ctgcaccgtg tcgtgcgggc
     2821 gttcgagcag gccggttacc tgacggacga gccgcagcac ccggagtggc ccgctgcccg
     2881 ccggggcatc cggctgctgg gcgacccggt actgaccgag ccgctcgccg cgcacctggc
     2941 cgccctgggt gccgtaccgc acacgacttc ggcggcacct gctcctgagg cgtcgccgcg
     3001 agacctcgac gacctgctgc acgaagaccc cgccgccgtc gtgtggtgcc tcgacggacc
     3061 cgtgcccgac ggactgtggg acgccgccga catgctgccc gagcgcggcg tcgcctggct
     3121 gcgctgccac cgggagggct ggcaggcgta cgtcgagccg ctcgccgccg ctcccggaga
     3181 cgtcacctcg gcccacatcc gggcccgccg gctcgccgcc acccccgcgc accgcgagct
     3241 ggccgcctac tggagcggtc cgcgtacgtc cggcgcaccg gtccggctca ctgtcccagc
     3301 cgccgggctg ctcgccgccc tgctcgccga tgatctcagg cggtgggcca tcgacgcgcc
     3361 cgacgccccc ggctcaggcg gccttccggc acggcgccgg ctccgacgcg tcgacctgcg
     3421 cacgctgacc gtcacggagc accccgtcct cccggtgccc gaggccgcga ccatgccgaa
     3481 gaccaagccg aagaccaagc cgaagaagga cggatgacgc cgttcagtga ggctgtcgaa
     3541 ggtctcgcca cggacgttca cctccccgac ggcgacggcc ccttcccgac cgttctcgtc
     3601 cgcaccccct acgaccgcgc ccggtaccgg gccgaggcac gcggctgggc ccgccacggg
     3661 ttcgccgccg ccgtccagga cgtgcggggc cggttcgcgt caccggggga gtggcacccg
     3721 taccagaacg aggccgccga cggagcggcg accgtccgct ggatccggcg acagccgtgg
     3781 agcgacggac ggatcgtcgc cgtcggcgct tcctacgccg cgcactgcgc gctcgtgctc
     3841 gccttcgacg cacccggcgg cgcccggccc gacgccgtcg tcgccgccgt accggcgctc
     3901 ggcgccgccg agacggcacg cgaaccctcc ggcgtggaac ggctgctgac ccgcgccgga
     3961 tggtgggccg cccacggcga ccggcgggac tccgacgaga gcgcgctgga caaggccctc
     4021 gccgcggacc ccggcctgct cacccacctg ccgctgaccg gcctccccga gcggctgggc
     4081 cggagcctgc cctcctgggc ggccctgtgg cggcaccgtg agcgcggccg cctcgtgtcg
     4141 cgggtggcgc acgccgatgt gcccctgctc gcggtcggcg gccaccacga tcacttcacc
     4201 gaggacaccg tcgaactatg gcgcgcctgg ggcggcccct cggcgcggct gctgctgggc
     4261 ccctggggac acggcctcgt caccgcgccc ggacccgacg ccggacccgc ccaccgggtg
     4321 agcctcggcg aactgtacgt gcgctgggtc cgccgcgccc tcgccggcga gctcgcccaa
     4381 gggcgccacg gcgcggtggc gctgggcggc ggcaacctgt ggctgcccgc cgacgcccac
     4441 ggcgagccgc gtacgcagcg gctgcggctg ctgcacggct ccgccttcac cgccgacccc
     4501 gaccgtcccg tccgctccga cgacctcacc gttcccaccg ttcccaccgg cggaccgccc
     4561 gaccgctgcg tgctggtcac cccgccactg ccgcgtccgc tcgacgtggt cggacccgtg
     4621 cgcgtacggc tgcgggccac cgcccacacc ccgtccgccg actgggccgc ccggctcgtc
     4681 gccctcacgc cggaagggag agccgaagga ctcgccgtcg gcgtcgtccg gcgcgaggaa
     4741 ccggcaggcc gggaaaccga gttgaccgtc gagctcggcc ggctcgcccg gcggctgccc
     4801 gcgggcagcc ggctccgcct ggagatcgcc ggacaccatt tcccggccca cgcccgcaat
     4861 ccccacaccg gggacgaccc ggtgaccgcc gaccggctga tcccctccgg gcgggcggtc
     4921 gacccccgga gcgtggcgct gcggctgccc gtgctcacgt cccgtcccac ccccaccgat
     4981 cccgccaagg agatcctgcg atgacggcgc tgctgccgct ggaagctctc gtcgatcccg
     5041 tctgcggcat cgtccgcaag gtcaagcccg tcgagcaccc cgtgggcgca ccgccccgct
     5101 acaccgcact caccgccgag atatccgatg cccgcaggct cggcctgtgg cccgccgacc
     5161 gggtctccct cggcaccacc ttcggcgacc ccgggcaagc ccgtgtcgcc gcgatagcgg
     5221 aaggggtgga gcggtactgc ggcaaccgcg tgcccccgcc cggtcacccc gacgcccccc
     5281 tgcgcgccac cgccgccgag ctggccgaga agggcctgcg gctctacggc cccgacgatc
     5341 tgcccgccta cgcgcagtgg cagtacgacc gggagaagtt cccctaccgc cccctcaccg
     5401 ccgacactcc ggccctgtgg acgcgcggcg ccgagcggct gcccgacggc acgaccaccg
     5461 aggtctgggc gcccgtcgca ctcacccacc tcaactggcg acagggagag ctgcgctcgc
     5521 tgccccgcac ccaccacctc aactacgccg ggatcgccac cgggcagggc ctcgacgacg
     5581 cggccgagcg cggtctgctg gagatcgtcg aacgcgacgc cctggaactg tggtggcacc
     5641 tcgacggccc ggcccgcggc atcgacccgg ccagtgtgcc cggcctcgcc gacgacctcg
     5701 ccggatccgc gctcgacgtc cacctcgtcg agatgccctc ggagttcgcc ccctgcatgg
     5761 ccgcactcgt ccacgatccc cggctcggcc tgtacgccgc cggattcgcc tgcaagtacg
     5821 acccggccga ggccgcccgc aaggccgtcc tcgaggcggt ccacacctgg gtcttcaccc
     5881 agggcctgac cgaccccgac ggctgggtgt tccaggccgt cgaggccggt ctgctcgccc
     5941 gcgggctcta tctggagcac cgggccgacg gccgttatct cgacgcgtgc ggcgagcagt
     6001 tcgagcacgt ccgggacctt ggcgcgcatg tgcaggtctg gctggacgaa cggatggcgc
     6061 ccgaagcccg gcgcttcacc gggccggcgc tcgggaccgt gtccctcgac gcggtccggc
     6121 ccggcagccg ggaccggctg gagcgcgcac tgcacgcggg cggccaccgc gtcatgacgt
     6181 tcgacctcac caccgaggac gtggccgaga ccccgctgcg cgtcgcccgc gtcctggtct
     6241 ccggtctcct ccccaacgcc cccgccgctt tcgggtactt cggctgcccg cgcctggccg
     6301 agaccgccgt cgcacgcggc tggcgggccg gcgcaccggg cgcgccggag gacttcacgc
     6361 tggcgcctcc gccgcacatg tgagggcggc cgacgtggaa cacgcccctc gagaccgtcc
     6421 ggtgaatctc gtcgccgcgc tcgcccgcgc ccgctccccg gagcgtcccg gtcccgacac
     6481 acccgccggg cccgccgtcc gggcctggcc gggaccatcg cgtcccgtcc cggaggccgg
     6541 ccggcaagac ctcgacctgc gggccctgct gcgtctctcc ctggcggcct cggacgactc
     6601 cggacggctg cggcccgcgt cctccgccgg agccctgcac ccggtggaca ccgaactcgt
     6661 cgtgggtgcc gggtgctccc tgccgccggg ccgctacggc tacgacccgc tgaagcatca
     6721 cgtccaccgc ctcggccggc aacccgacgg cacaccgccg ggcgtgaccg ccgaactctc
     6781 cgtcaccgca cggcgcacgg tctcccacta cggccaccgt gcctggccgc tgttgctgct
     6841 ggacacgggg cacgccgccg cggcgctgtt cctcgcggcc cgcgcgctgg gtgcgggcga
     6901 gcccgaggta cggctggacg gactcgccga gagcccactc gccgccgtgc gcatcgcctc
     6961 gccgggcggg caggtcccgg gacgcccgct cgacggcacg caccgcccgc aaccgccggc
     7021 gggcgtgccc acggccgccg agctgctggc acgccgcagc gacccgccac cgctcccggg
     7081 cactccgccc ccggacgcgc tgcgggcggt cctcgccacc gccgcccggg cgagcgccgg
     7141 tgagctgcgc tggtgcgtcg ccgtcggcgc accacgaccc ggcctgctcg aactggccgc
     7201 cgacggcacg acactgcgac ggcgcgccgt gggggaggcc cgtccgacgc tcgcggcctg
     7261 ggccgcgggt caggcgtgga tcgcggaggc gggcgccgtc ctgctcgccc acggctgccc
     7321 cgcggacgcc gacgcgccgc acatccgccg cacccacctg cgggccggct tcaccgtcca
     7381 cctggcccat gtcaccgccc ggcgccacgg gctgggcgcc cggcccgtcg gctcctggca
     7441 gcaggcggac ctgggcgccg cgctcggtgc cgcgccgggc cgcgactgga tcgtccacgg
     7501 actggccctc ggcacccgcc acgccgacga ggagaacacc acgtgatcgt ccaccccgag
     7561 ctgcgccgcg ccgcccgccg cgcacggcgc cccctgctca cggccaccct cctgcagggc
     7621 accgtcaccc tcacccacct cgcgcaggcc gccctgctcg ccgtcgcact cgccgacctg
     7681 gcccgcggcg acaccggccg gctcccgtgg ctgctcgccg cggtgctcgc cgtcgtcgcc
     7741 gcccgtgccg gtctcgccat ggggcagcgg cgcaccgcca cccgcgccgg agcccaggtc
     7801 agggtggccc tgcgggacga attcctcgcc cacctggggc ggttggggcc cgcgcacctg
     7861 accagtgcgc gtgccggggc cgtacgcacc actctcgtcg acggagtgga gggtgtcgac
     7921 gcgtacgtct cccgctacct gccccagctc ctgatcaccg tcaccctgcc gcccctggtg
     7981 ctcgccgtcc tggccgcggt ggaaccgcgg gccctcctcg gcctcgtccc cgccctgctg
     8041 ctcgccctgt gcggcccgcg cgtctgggac cggctcctcg ccgcccgcgg caaggagcac
     8101 tgggacacct acgaggggct gggcgccgac tacctggagg ccctgcaggg catgcccgcc
     8161 ctgcgcgccg ccggcgcggt cggccgcacc cgcgcccgcc tggaggagcg ctcggcggcg
     8221 ctgcaccggg cgaccgtcgc caaactgcgg gtctccctgg tcgacaccgg catcaccgac
     8281 ctcgccgtcc agggcggcac cgccgccgcc gcgctcctcg cctgctggtc ggccgtcacc
     8341 ggatccacca cggcgaccgg cacctacctg gtgctgctgc tggcctccga gtgcttccgg
     8401 ccggtccgtg acctcgctcg cgagtggcac gccggatacc tgggggtgtc ggccgcggac
     8461 gggctcgccg cgctgcgcac cgccgagcct gccgtccgcg acaccggaac ggcgcccgcc
     8521 cactgggcgg caccgcccga actccgtttc gaggacgtcg ggttcacgta tgacggcgca
     8581 ccggcacccg ccctccacca tgtctccttc accgcggagg cgggccggac caccgcgatc
     8641 gtcggtccgt ccggcgcggg caagtccacg ctcctcgccc tgctcctgcg ccaccacgac
     8701 ccgcaggagg gccggatcac cctcgacggg cgccgcacga ccgagtacgc gctggattca
     8761 ctgcggcagg gcatcgccgt ggtctcgcag gagacgtacc tcttccacgc caccatcgcc
     8821 gacaacctgc gcctggcccg gccggacgcg acggacgacg acctgacgcg tgcgacgcgc
     8881 atcgccggcg tccacgccga gatcgccgcc ctccccgacg gctacgccac cgtcctcggt
     8941 gaacggggcg ccaccctctc cggcggccag cgccagcggc tcgcgctcgc ccgggccctg
     9001 ctggcggacg ccccggtgct cgtcctcgac gaggccacga gctcggtcga cgaacgccgt
     9061 gaggcggaca tcgtccggga gctgtcgaag gccgcgagcg gccggaccgt cctggtcgtc
     9121 gcccaccggc tcgccgccgt ccggcacgcc gaccgcatcg tcgtcctcga cgcgggacgg
     9181 gtggacgccg tcggcgagca caccggcctg gccgaggccg ggagcgtcta cacgcgcctc
     9241 gtcgaggccg gccacgtcca ccgagaagga gcccccgcat gagcagcgcc gccgacaccg
     9301 ccaccatcga cgcgggcgtt cccgcgcggg gctcgttgcg cgccctgctc cccgccctcg
     9361 ccgggcaccg cgccatgacg gtccgcacct gcgccgccgc tctcctcgaa cagggctccc
     9421 tggtcacact gctgacgctg gccgcgcaca ccgtgggaac agccgtcctc gaaggacacg
     9481 ccccctcggc cgccaccgtc accgcactcg tcaccctcgt tctcctacgc gccctgatga
     9541 cctggcgtga gatggacctc tcgcacgacc tggcctaccg ggtcctggcc gtcctgcgcg
     9601 tacgggtctt cgacgggctc gcccgcagcg cacccgcccg ggtcgccggc cggcgcagcg
     9661 gggacctcgc cgccacggcc atggcggacg tggaggcact ggagttcttc tacgcccaca
     9721 ccaccgccca gctcctggca gcgggaacgg tcttcaccgg cggcaccgcg gtcctcgcca
     9781 cggtggagcc ctggctgctc gcagccgtac tgccggtcgc ggtactgctc gccgcggcac
     9841 ccttcgccga cgcgcgcgga cgcgcggcgc gcggcagccg cacccggacg gccgtcgcca
     9901 ggctgtcggc cgacacggtg gacaccgtcg acgggctgcg ggaactgctc gcctgtggag
     9961 ccctggccga acggcgccgc cgactggccg agaggggacg gcaggtaggc gacgcccagc
    10021 gtgccgaggc cgtgtgggaa gccgtcgccg ccgcggtccg cgacctcctc atcgtggtcg
    10081 cggtgctcgg cgtggtggcc gcggcggcgc agtccgtgaa tgcggggcgg ctgcacggcg
    10141 catgggctcc ggcggcgatg gcgctggccc tggcggtcct cggcccggtc gcggaatcgg
    10201 cccgttccct gagccaggcc gtgtcactgc gcgccgccgc cgcccgggtc ggcgcggccg
    10261 tcaaggctcc cgcgctcgcc ccgccgcccg ccgcaccccg ctccctgccg tccggtccgc
    10321 tgggcgtccg gctgcaccgg gtgaggttcg actacggcgg cggtcccgta ctggacggcg
    10381 tcgaactgac cgtccccgcg ggtcagaccc tcgccctggt cggcgcctcg ggcgccggca
    10441 agtccacctg cgcccacctg ctggcccggt tctgggaccc gtccgaggga gcggtccagc
    10501 tggtacccgc cgacggggag cccgtcgacg tacgcgaggt gagcgatgcc gaactccggc
    10561 gcgccgtcgc gctggtgggc caggagtcgc ccctcttcca cggcaccctg gccgagaacc
    10621 tgcggctcgc cgcccccgag gcggacgacg acctgctcac cgagacggcc cgcctgtgcg
    10681 gcgtcgaccg gatcgccccg atggacaccc cggtcggtga gcgcggatcc accctctccg
    10741 gaggccagcg ggcccgcatc gccctcgccc gcgcgctgct ggcccggccg cgggtcctcg
    10801 tactcgacga gtccaccgcc cacctggaca acgccagtga cgcccggctc gccgccgcac
    10861 tgaagcagga ggaccgtacg acggtcgtca tcgcgcaccg ccgcgccacc atccgccgtg
    10921 ccgaccgcat cgccgtcctc gaagccggcc gtatcgccga ggagggcacc tgggaggagc
    10981 tcaccggacg ccccgacagc gcactcaacc gcagcctcgc ccacatccct tcctgagggc
    11041 ggcacgtcat cacggacagc gtccgcaccc gtcaccatgt cgaacgtacg gctgtgccgg
    11101 tccttccagg ccacgagtac cggctcgatc aacgaccact gctcgtccgg cagggggctc
    11161 ggtcacggct tccgttcgct caccccgcca ctgcggcagg acaccgtcca ctgaccagcg
    11221 gtcttcaccc cgcccacacc atcaggcgac accacaacca ttcaaagact cacgaaccgt
    11281 cctctgagaa acgcgaaccc ggcgtctgaa cccgcagagc tccgcgttac ggtctgaccg
    11341 ccggcctcct cgcctcctcg ggctcgtggg cgccgagccg agc
//
