LOCUS       NZ_BMVW01000020        22515 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence20, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000020
VERSION     NZ_BMVW01000020.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 135163)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 29996
            Orig. end                         :: 52511
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22515
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22515
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22515
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12515](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12515
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            74..1333
                     /gene="rho"
                     /locus_tag="IE242_RS33090"
                     /old_locus_tag="GCM10010365_67880"
     CDS             74..1333
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008186 - ATP-dependent activity, acting
                     on RNA [Evidence IEA]"
                     /GO_process="GO:0006353 - DNA-templated transcription
                     termination [Evidence IEA]"
                     /codon_start=1
                     /gene="rho"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972093.1"
                     /locus_tag="IE242_RS33090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67880"
                     /product="transcription termination factor Rho"
                     /protein_id="WP_373299647.1"
                     /transl_table=11
                     /translation="MGVSLPPPAALQFSSPPALLFPCPPVPVRAVPKGRSSMTTTLETP
                     STPGRLTSPVSGVLDIARDGQGHLRTEGCLPSSGDPQVPAALIRRYGLRKGDTVDGVRG
                     GGHTLAEVALINGRTPGELRDRPRFHDLTPLHPHDRLRLEHPASGLIGRLVDLVAPVGK
                     GQRGLIVAPPKTGKTVLLQQLAAAIAGNHPECRLMVLLLDERPEEVTDMRRSVRGEVYA
                     STFDRTPKQHIALAELVVERAKRLVEQGEDVVILLDSLTRLCRAHNNAAAAGGRTLSGG
                     VDAAALHGPKRLFGAARRTEERGSLTVLATALVETGSRADDFFFEELKSTGNMELRLDR
                     GLADRRVFPAVDIVPSGTRREELLFTAGELTAVRGLRRALRSRDGKTQAPLETLLERLR
                     ATPDNAAFLRQVQPTFPAAA"
     gene            1436..>2380
                     /locus_tag="IE242_RS33095"
                     /old_locus_tag="GCM10010365_67900"
                     /pseudo=""
     CDS             1436..>2380
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012970.5"
                     /locus_tag="IE242_RS33095"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67900"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIGFSARAAVSCAAVCLLGALASAPGAAAAPPASGPRATRSTAL
                     SPSLSPAPSLSPAPSPPSSPSPSSSQRTSLHRPGTQVRPRPGAPKVPDGLSALSWLVAD
                     AGTGEVLAAHDAHRRLPPASTLKTLFALALLPALPPGARHTVTEKELADVGAGSSLVGV
                     KEDRTYRVADLWRGVFLSSGNDAVHVLAALGGGRRAAAARMQETARALGAHDTHVVSPD
                     GYDAPGQVSSAYDLAVFGRAGLRNPEFARYCATVRASFPADGWSYGIQNTNRLLTGDGV
                     DRYPGLIGIKNGYTSRAGNTLVAAARRDRRTLVV"
     gene            complement(2419..3849)
                     /locus_tag="IE242_RS38960"
     CDS             complement(2419..3849)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044011.1"
                     /locus_tag="IE242_RS38960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase 87 family protein"
                     /protein_id="WP_308436802.1"
                     /transl_table=11
                     /translation="MTAGPRATDRRRLLLLLLLVGAVTLFTATVPLLRDWFDLRVYHGA
                     VHAWTHQGGRLYDYRVPGTAYGFTYPPFAAVAMLPLALVGLGTAVVLCLLLNLLASAAV
                     LYVLFGPLLRRYGRFGAGLAVCLLALFEPVRDTVSFGQVNLLLLAVVLGDAWLLSTGRE
                     KRAGVGIGLAAAVKLTPALFIGLLLIAGRWRAAGRATAVAAAATAAAAWIAPDASRFYW
                     TEALWDTGRIGRLDYVSNQSLQGVLARLGEPDRAVWAVTVLCVLGVWAWQARRGARAGD
                     WTGAFAVTGLASCLVSPITWVHHLVWVLPSFAVLLRHRRLVGVAACAYALLCTSVVWLW
                     VDAPHTAAGFLGGNTYVWITLGLLLGLPVGQPRPEWPPFSRSNRSTSATAPAPTTAAPA
                     MAAAADQPGPVSPPFTTVTPAGPASGSAPVPAPAPAPAPGSEPGPVGGRERGGSTEPTG
                     STRPAARKPQSSSERASS"
     gene            complement(3971..5368)
                     /gene="mptB"
                     /locus_tag="IE242_RS33100"
                     /old_locus_tag="GCM10010365_67930"
     CDS             complement(3971..5368)
                     /codon_start=1
                     /gene="mptB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662765.1"
                     /locus_tag="IE242_RS33100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67930"
                     /product="polyprenol phosphomannose-dependent alpha 1,6
                     mannosyltransferase MptB"
                     /protein_id="WP_189866018.1"
                     /transl_table=11
                     /translation="MASPVRLRHCRALGLVGSAVLALGGETAGALPVRELPAPSSAGAA
                     LGLVGVYFGVVLLIAAWVLLGRVVRGPRPPAPRALLVTLAVWAAPLLLAPPLFSRDVYS
                     YLAQGAMVDAGIDVYAHGPARLGGPLADEVAPVWRHTTTPYGPVFLGIVAGLSGVLPGD
                     LPAGLLALRLVALTGVALMAVALPRLARHCGADPAAALWLGALNPLVLLHLVAGAHNDA
                     VMLGLLGMGLVAARGRRYPLGAVLVTLAALVKAPAALGLLAVVVMRGRARAPRTAVTVA
                     AVALATTAAATAVTGTGHGWIAALRTPVSPGNWSPTSLLGRATGALLARLGSDLAPLAL
                     PLWHLAGLLAGAVVVLFIWLRLRPGPVYALGLSLAALAALGPAIRPWYALWGLFLIAAA
                     APKGSARGRVTAVSAVSAVLALAVLPAGGPPDAAQTALAVSGGALALVVLWQARQTAWP
                     PALERAA"
     misc_feature    5681..5693
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            6058..6735
                     /locus_tag="IE242_RS33105"
                     /old_locus_tag="GCM10010365_67940"
     CDS             6058..6735
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554995.1"
                     /locus_tag="IE242_RS33105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67940"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_189866020.1"
                     /transl_table=11
                     /translation="MASNLLTPARLGQRTLILTTAAIPLTGWTVHAVALHRRLAAARRD
                     PLTGLLRRDSFTAKARQLLRRHGDDVLVVLVDQDHFKTINDTLGHAAGDTVLTATAARL
                     QAWAGPRAAVGRLGGDEFAIVLRVEPGRREVRLEQLVRMLHTPVSLDDGQTVDVAASVG
                     AAAPDTLGVRDLSQLQRAADAALYDGKHSGRAVLAHLRHTQVPSINGRRAGRPGTAVWG
                     RAA"
     gene            complement(7403..7777)
                     /gene="crcB"
                     /locus_tag="IE242_RS33110"
                     /old_locus_tag="GCM10010365_67950"
     CDS             complement(7403..7777)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474650.1"
                     /locus_tag="IE242_RS33110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67950"
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_189866022.1"
                     /transl_table=11
                     /translation="MNWVLVVLGGMAGAPLRYLTDRAVQARHDTDFPWGTFTVNVAGSL
                     VLGLLTGAVAAGAADSRVQLLLGTGLCGALTTYSTFSYETLTLARQGARWQAAANVTVS
                     VAVGLAAACVGTALARLLWA"
     gene            complement(7774..8292)
                     /gene="crcB"
                     /locus_tag="IE242_RS33115"
                     /old_locus_tag="GCM10010365_67960"
     CDS             complement(7774..8292)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118136.1"
                     /locus_tag="IE242_RS33115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67960"
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_189866024.1"
                     /transl_table=11
                     /translation="MSVPPPERAPDAPVRVPVRQPYARRPSPWHGQASVVAVVALGGGI
                     GATARYGASLLWPTRQGGFPWTTFCVNVVGCAVIGVFMVVITEAWAAHRLVRPFFGTGV
                     LGGFTTFSTYAVDVERLLDAGHAVTALACFAATPLAALTAVWTASSATRRLLVSRQNAR
                     TGRADGTPS"
     gene            complement(8517..9491)
                     /locus_tag="IE242_RS33120"
                     /old_locus_tag="GCM10010365_67970"
     CDS             complement(8517..9491)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004955615.1"
                     /locus_tag="IE242_RS33120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67970"
                     /product="SMP-30/gluconolactonase/LRE family protein"
                     /protein_id="WP_189866026.1"
                     /transl_table=11
                     /translation="MDRSRGGLVPLAYVGIGGRGPEDVVADDRGRVLTGVEDGRILRLS
                     RISDPVRTRVEVLAETGGRPLGLELLPDGDLLVCDARMGLLRVAVGDGTVRVLADSVAG
                     EPLAFCSNAVALPDGTVCFTASSRRYPLEHWVGDLVEHSGTGRLLCLAPGKDTPDVLLD
                     GLQFANGLALSGDESFLVIAETGARRLTRYWLTGPDTGRSEPFVEDLPGAPDNLWRGPD
                     GLTWVALAGPRVAALDAAHRAAPAAVRRAAARVALRAPFRPGGFAGVIAVDDTGRIVHD
                     LTRRRSGFRMVTSVCRAEDRLVLGSVWERGVAVCELPGEHQGG"
     misc_feature    complement(9775..9788)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.99"
                     /tool="antismash"
     gene            9851..9979
                     /locus_tag="IE242_RS33125"
                     /old_locus_tag="GCM10010365_67980"
     CDS             9851..9979
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="IE242_RS33125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67980"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_189866028.1"
                     /transl_table=11
                     /translation="MEEQNTQAVYEAPELMEAGDFADLTLGGFGPDIETFTIFGLL"
     misc_feature    complement(9996..10010)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.87"
                     /tool="antismash"
     gene            10001..11836
                     /locus_tag="IE242_RS38720"
                     /old_locus_tag="GCM10010365_67990"
     CDS             10001..11836
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="IE242_RS38720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_67990"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_189866030.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.2e-39, bitscore:
                     129.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFVLLPDSDVADGAARSVCASPGVRVIAHASGRPWLVGRWPAGR
                     VRVAAAGQARVAVAGFCPASGQELTAAAGRLRSLADLDAVARRFGGSAHLLASVGGRVR
                     AQGTASGVRAVFHAELAGVTVAADRPDTLARLIGAEVDDEVLALRLLTPYVPHPLLDRP
                     VWRGVHQVPAGRCLVLNRDGVARTATWWSPPEPVVPLREGVPAVREALTDAVRGRVRAA
                     ARVVSTDLSGGLDSGTVTHLAAGAGPRLVTVRIPQLDAAGDDAEWASRTTARLPGAEHL
                     LLEYEQAPTMFAGLDGGTGLTLASEPPFWVRAGARLVDIAGRVAARGSRLHLCGHGGDE
                     VFHASAVSLHTLVRSRPWAGARLLRERRALGRWPLGSTVRGLADSRSFPAWLACAADQL
                     PGPLPSPFTPHLGWTPPLRIPAWATPDAAATVRDLLRQTAYEEPRPLGHGRAAHTTVEA
                     VHRAGAMVRYAAGLTAAHGVDFAAPYLDDRVIEAALAVRLRERARPRRYKPLLAEAVRG
                     LVPEDLLRRSTKGDYGEDVFDGLHRHRASLLRLFDGSLLARRGLVDEAAVRAVLSADHL
                     FTLPLQALEPTLACEVWLRALPAPVPQRACAEGAL"
     gene            11833..12099
                     /locus_tag="IE242_RS33135"
                     /old_locus_tag="GCM10010365_68000"
     CDS             11833..12099
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946593.1"
                     /locus_tag="IE242_RS33135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68000"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_308436803.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.4e-26,
                     bitscore: 84.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 4.1e-08,
                     bitscore: 26.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.2e-16, bitscore: 52.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVTFTLAPDVVPTDTEHGTVLLDERRGRYFKLNATGTLVLRAL
                     LDGASGERAAALLQERYGIDAERARADVSALIDAVCAARLARA"
     aSDomain        11842..12093
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE242_RS33135_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="6.00E-27"
                     /identifier="RREFam002.1"
                     /label="IE242_RS33135"
                     /locus_tag="IE242_RS33135"
                     /protein_end="87"
                     /protein_start="3"
                     /score="84.5"
                     /tool="antismash"
                     /translation="VTFTLAPDVVPTDTEHGTVLLDERRGRYFKLNATGTLVLRALLDG
                     ASGERAAALLQERYGIDAERARADVSALIDAVCAARLAR"
     aSDomain        11845..12012
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE242_RS33135_Lasso_Fused_RRE.1"
                     /evalue="1.00E-08"
                     /identifier="RREFam003.1"
                     /label="IE242_RS33135"
                     /locus_tag="IE242_RS33135"
                     /protein_end="60"
                     /protein_start="4"
                     /score="26.1"
                     /tool="antismash"
                     /translation="TFTLAPDVVPTDTEHGTVLLDERRGRYFKLNATGTLVLRALLDGA
                     SGERAAALLQE"
     gene            12096..12515
                     /locus_tag="IE242_RS33140"
                     /old_locus_tag="GCM10010365_68010"
     CDS             12096..12515
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638600.1"
                     /locus_tag="IE242_RS33140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68010"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_189866032.1"
                     /sec_met_domain="PF13471 (E-value: 6.2e-27, bitscore: 86.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPIAFGERYDLPPRRRLAARLAVASARALAALPPRRLRAALHL
                     VRTGARPARAAQTLGARDAVVAVSARCAGRHCLQRSLATALLCRMAGTWPTWRTGVRTA
                     PFRAHAWVEADGRPIGEPHPAGYYTPTLTVGPANR"
     gene            complement(12636..14228)
                     /locus_tag="IE242_RS33145"
                     /old_locus_tag="GCM10010365_68020"
     CDS             complement(12636..14228)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126052.1"
                     /locus_tag="IE242_RS33145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68020"
                     /product="arabinogalactan endo-1,4-beta-galactosidase"
                     /protein_id="WP_189866033.1"
                     /transl_table=11
                     /translation="MFHPRRDSGRDSGRILRTLLLPLAAGLALTALPAQSASAASTLTN
                     GGFESDGTGTATPAGWSTYSAAGQNAASFTEAGGRSGSYRLTHWSSSAYKVETYQYLSG
                     LTNGDYTLTAWVRSGGGQKSAYLALKNCGGAEQRTDLPVSSSGWIRIVASVAVTNNQCT
                     ISVNSDADAGNWINVDDLTFTKGRTGLAVKGSDVSSLAKSEALGGTYRTSSGTKGDPLA
                     ILKSAGQNYARVKVWVNPADGYNNKARVLSLAKRIKAQGMKLLVDFHYSDTWADPGAQS
                     KPTAWAGHSYSQLKTDVYNHTYDVLSALKAQGTTADMVQVGNEINGGMLWDEGSTDNWP
                     QLAGLLNSGYSAVKAVNSSTAVALHLAKGGDLAGTRWWFDNAVANGVKFDVIGLSYYGY
                     WHGSLVDFQTTLDDAASRYGKPVYVAETAYPFRLDSEDTHENIIDLSGELVAGYPASTA
                     GQTAWMKDVASIVEAVPNGRGLGVFYWESTWTAVTGNGWDPADPTSGNGWENQALFGYD
                     DRALPAMEWFRHR"
     gene            complement(14956..16977)
                     /locus_tag="IE242_RS33150"
                     /old_locus_tag="GCM10010365_68050"
     CDS             complement(14956..16977)
                     /GO_component="GO:0009341 - beta-galactosidase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004565 - beta-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982763.1"
                     /locus_tag="IE242_RS33150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68050"
                     /product="beta-galactosidase"
                     /protein_id="WP_189866149.1"
                     /transl_table=11
                     /translation="MPETNPKGLTRLAFGGDYNPEQWPESVWHEDVRLMREAGVTMVSV
                     GIFSWALLEPAPGTYDFGWLDRLLDLLHENGIRADLGTPTVVPPVWFYRAHPEALPVAA
                     DGTRYEFGSRGAICHSNADYRAAAANITTQLAERYGNHPALAMWHVHNEYGVPVSACYC
                     DSCAAHFRRWLATTYGTVEAVNEAWGTAFWGQRYTDFEQINPPRVTPTVGNPGQALDYK
                     RFADATIRENFVAERDILHRLSPGVPVTTNFMTALSQCDSIDYWAWGREVDLVTNDHYL
                     ITDGRRTHVNLAMAADLTRSVAGGAPWLLLEHSTSGVNWQPRNPAKAPGQMARNSLAHV
                     ARGSEGAMFFQWRQSRRGAEKFHSAMVPHAGTDSRVWREVVELGASLDSLATIRGTRTV
                     ADAAVLWDWHSWWAQNLQWRPSEDHDARERADAFYEALYDRHLTIDFAHPEADLSAYPL
                     VVVPALYLMTEAAGNNVREYVENGGTLVVSYFSGIVDEHDAVHEGPYPGALRDVLGLTV
                     EEFSPLLAGDGVRLTGPDGSELTGDVWTEFVVPRGAETVWEYADGLTAGRPAITRHRLG
                     EGSAWYVSTRLDAQGLDALLGWAADDARIAPRADLPRDVEVVRRAGASGTYLFVINHSS
                     SDAKVPLDGHGTEVLTGERAAGHLAVPAGAVRVVRLDG"
     misc_feature    complement(17056..17073)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.03"
                     /tool="antismash"
     misc_feature    17093..17110
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.56"
                     /tool="antismash"
     gene            17176..18498
                     /locus_tag="IE242_RS33155"
                     /old_locus_tag="GCM10010365_68060"
     CDS             17176..18498
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474656.1"
                     /locus_tag="IE242_RS33155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68060"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_189866036.1"
                     /transl_table=11
                     /translation="MPTNTKHRRFVATAVAVTLGATTLAACGSSDDDSDAQSGPAKLTY
                     WTWTPGMDKVVDLWNKGPGKEQQITVTVKKQASGDTLVTKILTAHKAGKGPDLVQAEYQ
                     ALPTLVSNDAVADIAGEAGEAEGDFAEGVWQQTTLGTDAVYAIPQDIGPMMFYYREDLF
                     KEYGLTVPTTWDEFAETARKLKEEAPDVDLTTFSANDSGLFAGLAQQAGAKWWTTEGQK
                     WKVGIDDAATQKVADFWGGLVEEGAIDNQPMYTPAWNKALNTGKQIAWVSAVWAPGTLT
                     TAAPDTAGKWKMAPLPQWSKSEDVTGSWGGSSTAVTTDSKHKEAAAKFATWLNTDQEAL
                     AALAKEGGIYPAATTAQLSEAFAEPPAYFSNQPDFYTRAAAIAKTTAPSAWGPNVNVAY
                     TTFKDAFAAAAKDRSDFGAALTTMQDETVADLEKQGFEVAE"
     gene            18636..19505
                     /locus_tag="IE242_RS33160"
                     /old_locus_tag="GCM10010365_68070"
     CDS             18636..19505
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526884.1"
                     /locus_tag="IE242_RS33160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68070"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_189866151.1"
                     /transl_table=11
                     /translation="MLPATVLFALFFALPIGYALWLSLHKVEVKGLGLGAGARQEVWAG
                     LENYADALTDSELLAGALRVVGYGAIVVPVMLGLALVFALMLDSEKVRLTRFTRLAIFL
                     PYAVPGVVAALLWGFLYLPDVSPFYFVLDELGLPQPDLLDGGPLYLALSNIAVWGGTGF
                     NMIVIYTSLQSIPNEVYEAARLDGATPLQIALRIKIPMVAPSLVLTFFFSIIATLQVFS
                     EPTTLKPLTNSVSTTWSPLMKVYQDAFGKGDIHAAAAGAVLIAVATLVLSFGFLRAANS
                     RSKQEEAR"
     gene            19525..20433
                     /locus_tag="IE242_RS33165"
                     /old_locus_tag="GCM10010365_68080"
     CDS             19525..20433
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474661.1"
                     /locus_tag="IE242_RS33165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68080"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_189866038.1"
                     /transl_table=11
                     /translation="MSTLAVRKSAPAAGTTPGTAQGPPARRRRIALVPTLTLVLGALYC
                     LLPVAWVVIAATKSGRELFSTFTFLPGTGFADNLSDLNAYRDGVYWKWMGNSALYAGLG
                     ALLSTAVSAVSGYALAIYRFRGRETVFSILMAGVLMPPVILAIPQYLLLAKADLTDSYW
                     SVLLPLVLSPYGVYLARIYAAAAVPGDVVEAGRMDGAGEWRIFTRIALPMMVPGLVTVF
                     LFQFVAVWNNFLLPYIMLSDDEKFPITLGLFTLLEQGSNTPALYTLVITGALLAVLPLI
                     ALFLAVQRFWSLDLLSGAVKS"
     gene            20430..21461
                     /locus_tag="IE242_RS33170"
                     /old_locus_tag="GCM10010365_68090"
     CDS             20430..21461
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114644.1"
                     /locus_tag="IE242_RS33170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68090"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_189866040.1"
                     /transl_table=11
                     /translation="MTMSNTGGRRRPPTIHDVAREAGVSRGTVSRVLNGGHYVSPAAQE
                     AVNAAIRKTGYVVNRHARSLITGRSDSVGFLLTEPQERFFEDPNFNVLLRGCTQALAAH
                     DIPLLLMLAGTKDERRRITRYITAGHVDGVLLVSSHSGDPVAEELREAGVPLVACGKPI
                     GLGSKVSYVAADDRDGARDMVRHLLSLGRRRIGVVTGPLDTPGGVERLAGYREVLTEAG
                     VGVEERLIVSGDYSRASGEAGAERLLAQAPDVDAVFVASDLMAQGVLSALRRAGRRVPE
                     DVAVGGFDDSPAATAATPALTTIRQPWDRISNEMVRVLLAQIGGEDPAAVILPTELVRR
                     DST"
     gene            21563..21955
                     /locus_tag="IE242_RS33175"
                     /old_locus_tag="GCM10010365_68100"
     CDS             21563..21955
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118142.1"
                     /locus_tag="IE242_RS33175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68100"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_189866042.1"
                     /transl_table=11
                     /translation="MAANTAGTRLEDRWRDILSVHARTMCEIDRALHPHGLGASDFEVL
                     DLLVSAAAENSGEACRVQNIACRVHLSQSALSRLIGRLEKDGLVERSICEEDRRGVWVA
                     LTEKGRDLHARVLPLQRAALSRTLDG"
     gene            complement(21984..22418)
                     /locus_tag="IE242_RS33180"
                     /old_locus_tag="GCM10010365_68110"
     CDS             complement(21984..22418)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988135.1"
                     /locus_tag="IE242_RS33180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_68110"
                     /product="SseB family protein"
                     /protein_id="WP_189866044.1"
                     /transl_table=11
                     /translation="MDTPPYDHTAYDHIAPESVTAAQRALTTLAEDTGDAVALDTLAHS
                     DVLIPVPDDASDEDATDPTVVALPVLEQPGGEQVVPVFTSETEMAGLLPSVERYRLVPL
                     GALAAQWPDGDLSLTIDATSPYGLTLTPQGVRTLLARPYD"
ORIGIN
        1 ggtccggccg ccgcacgagg cgccgtaccg aggcgtgctc atcgcgttca cggcgtggtg
       61 tcttccgccg cacataggcg tgtcccttcc gcctccggca gctctccagt tctccagccc
      121 tccagctctc ctcttcccct gcccccctgt gcctgtccgc gcagttccga aaggacgttc
      181 ctccatgacc accacactcg aaaccccctc caccccaggg cggctgacgt ctcccgtctc
      241 cggcgtcctc gacatcgcgc gggacggcca gggccatctg cgtaccgagg gctgcctgcc
      301 ctcctcgggc gacccgcagg tgcccgccgc gctcatccgc cggtacggcc tgcgcaaggg
      361 cgacaccgtc gacggtgtac gcggcggcgg acacacgctc gccgaggtcg cgctgatcaa
      421 cggccgcacg cccggagagc tgcgcgaccg tcctcgtttc catgacctca ccccgctgca
      481 cccgcacgac cggctccgtc tggaacaccc ggcgagcggt ctcatcggac gcctcgtcga
      541 cctggtcgcg cccgtcggca agggccagcg cggcctgatc gtggcaccgc cgaagaccgg
      601 caagacggtg ctgctccagc agctggccgc cgcgatcgcc ggcaaccacc ccgaatgccg
      661 tctgatggtg ctgctgctcg acgaacgtcc cgaggaggtc acggacatgc ggcgctccgt
      721 acggggcgag gtgtacgcct cgacgttcga ccggacgccg aaacagcaca tcgcgctcgc
      781 cgaactcgtc gtggaacgcg ccaagcgcct cgtcgagcag ggcgaggacg tcgtgatcct
      841 gctggactcg ctgacccggc tgtgccgggc ccacaacaac gcggccgccg ccgggggccg
      901 caccctgagc ggcggtgtcg acgccgccgc gctgcacggc cccaaacggc tcttcggcgc
      961 cgcgcgccgc accgaggagc gcggctccct caccgttctg gccacggcgc tggtggagac
     1021 cggctcacgc gccgacgact tcttcttcga ggaactgaag agcacaggca acatggagct
     1081 ccgcctcgac cgcggcctcg cggaccgccg tgtcttcccg gccgtcgaca tcgtcccctc
     1141 cggcacccgc cgcgaggaac tgctgttcac cgcgggcgaa ttgaccgccg tacgagggct
     1201 gcggcgcgcc ctgcggtcgc gggacggcaa gacgcaggca cccctcgaaa cgctgctgga
     1261 gcggctgcgc gccaccccgg acaacgcggc gttcctgcgc caggtccagc cgacgtttcc
     1321 cgccgccgcc tgaacgctgg gcacgccgcc cgggccttga tgcatccgag tgctcgatgc
     1381 ccgcactcgg ccacggcacc cggacgggcg cggcaggcgt tcctacgttg gcgccatgac
     1441 catcggattc tcggcccgcg ccgccgtctc ctgcgccgcc gtctgcctcc tcggggcgct
     1501 ggcttccgct ccgggtgccg ccgcggctcc tcccgcgtcg ggcccgcgcg cgacgagatc
     1561 cacggccctg tccccgtccc tgtccccggc tccctccctg tccccggctc cctccccgcc
     1621 ctcgtccccg tccccgtcct cgtcacagcg gacgtcgctg caccggcccg ggacccaggt
     1681 gcggccgcgg cccggggcgc cgaaggtccc ggacgggctc tccgcgctgt cgtggctggt
     1741 ggccgacgcc ggcaccggcg aggtgctggc cgcgcacgac gcgcaccgca gactgccgcc
     1801 cgccagcacc ctcaagaccc tcttcgcgct cgccctgctg ccggccctgc cccccggcgc
     1861 ccgccacacc gtcaccgaga aggaactggc ggacgtcggc gccggcagca gcctggtcgg
     1921 ggtcaaggag gaccgcacct accgggtggc ggacctgtgg cggggtgtct tcctcagctc
     1981 cggcaacgac gccgtgcatg tgctggccgc gctcggcggc ggccggcggg ccgcggcggc
     2041 ccggatgcag gaaacggccc gcgccctggg cgcccacgac acccatgtcg tctcccccga
     2101 cggctacgac gcgccgggtc aggtctcctc ggcgtacgac ctggcggtct tcggccgggc
     2161 cgggctgcgc aacccggagt tcgcgcggta ctgcgccacc gtccgggcca gcttcccggc
     2221 ggacggctgg tcgtacggca tccagaacac caaccggctc ctcaccggtg acggcgtcga
     2281 ccggtacccg ggactgatcg gcatcaagaa cggctacacc agccgagcgg gcaacacgct
     2341 cgtcgccgcg gcccgccggg acaggcgcac cctcgtcgtc accgtcatga atccgcggcg
     2401 gggcggcagc ctcgccgtct acgaggaggc gcgttcgctg ctcgactggg gcttccgggc
     2461 ggcggggcgc gtcgacccgg tgggctcagt gctgccaccg cgctcccgac cgccgaccgg
     2521 tcccggctca ctgcccgggg ccggagccgg ggccggggcc ggaaccgggg ccgatcccga
     2581 agccggaccc gcgggcgtga ccgtggtgaa gggcggggag accggtccgg gctggtcggc
     2641 ggcggccgcc atcgcgggcg ccgccgtggt cggcgcgggc gcggtggcgc tggtgctgcg
     2701 gttgctgcgg ctgaagggcg gccactccgg gcgcggttga ccgacgggca gtcccagcag
     2761 cagtccgagt gtgatccaca catatgtgtt gccacccagg aagccggccg ctgtgtgtgg
     2821 ggcgtcgacc cacagccaga cgacactggt gcacagcagc gcgtacgcac aggccgccac
     2881 ccccaccagc cgccggtgcc gcagcagtac ggcgaaggac ggcagcaccc acaccaggtg
     2941 gtgcacccag gtgatcgggc tcacgaggca ggaggccagc cctgtcaccg cgaacgcgcc
     3001 ggtccagtcc ccggcccgcg ctccccggcg tgcctgccac gcccacactc ccaggacgca
     3061 caggaccgtc accgcccaga cggcccggtc cggctctccg agccgggcca ggaccccctg
     3121 gagggactgg ttggagacgt agtcgaggcg gccgatccgg ccggtgtccc acagcgcctc
     3181 ggtccagtag aagcgggagg cgtccggcgc gatccaggcc gccgccgcgg tggcggccgc
     3241 ggcgacggcg gtcgcgcgcc cggcggcccg ccaccgcccg gcgatcagaa gcagtccgat
     3301 gaacagcgcg ggcgtcagct tcaccgccgc ggccaggccg atcccgacgc ccgcccgctt
     3361 ctcccggccg gtggacagca gccaggcgtc accgagcacc acggccagca gcaggaggtt
     3421 cacctgcccg aagctgaccg tgtcccggac cggttcgaac agcgcgagca ggcacaccgc
     3481 cagcccggcg ccgaaccggc cgtacctgcg cagcagagga ccgaacagga cgtacagcac
     3541 ggccgccgac gccaggaggt tgagcagcag acagagcacg acggccgtgc ccagtcccac
     3601 cagtgccagc gggagcatcg cgacggcagc gaacggcgga tacgtgaagc cgtacgccgt
     3661 ccccggcacc cggtagtcgt agagacggcc cccctggtgc gtccacgcgt ggacggcgcc
     3721 gtggtacacc cgcaggtcga accagtcccg caggagggga acggtggcgg tgaagagcgt
     3781 gacggcgccg acgaggagga gcagcagcag gagccgccgc cggtcggtgg ctcgcggccc
     3841 agctgtcata ccgggggatc caggtgtcct accggggagt ccaggcgtca taccggggag
     3901 tccaagtgtc gtgccggggg tccaagtgcc gtgccacgtg gaagaggtgt cgtgccgcgc
     3961 ggttcagacg tcatgccgcg cgctccagcg ccggtggcca tgccgtctgg cgggcctgcc
     4021 agagcacgac cagggcgagg gcgccgccgg acacggcgag ggctgtctgc gcggcgtcgg
     4081 gcggcccgcc ggcgggcagg acggccagcg cgaggacagc gctgaccgcg ctgacggcgg
     4141 tgacccggcc tcgcgcggag cccttcggcg ccgccgcggc gatgaggaac agtccccaca
     4201 gcgcgtacca gggccggatc gccgggccga gcgccgccag cgcggccagg ctgagcccca
     4261 gggcgtacac cggaccgggc cgcagcctca gccagatgaa cagcacgacg acggcgcccg
     4321 ccaggagtcc ggccaggtgc cacagcggca gcgcgagcgg cgccaggtcg ctgccgaggc
     4381 gggcgagcag ggcgccggtg gcgcggccga ggaggctggt gggcgaccag ttgcccggtg
     4441 acaccggggt gcgcagggcg gctatccatc cgtgtcccgt gccggtcacc gcggtcgccg
     4501 cggcggtcgt ggcgagcgcg acggccgcga cggtgacggc ggtccgcggc gcgcgggcgc
     4561 gcccccgcat caccacgacg gcgagcagcc cgagcgccgc gggcgccttg accagcgcgg
     4621 cgagcgtcac gaggacggcg cccagcggat accggcggcc ccgcgcggcc accaggccca
     4681 tgccgagcag ccccagcatg acggcgtcgt tgtgcgctcc ggccaccagg tgcagcagca
     4741 ccagcgggtt cagggcgccc agccacagcg cggcggccgg gtcggcgccg cagtgccggg
     4801 cgaggcgggg cagcgccacc gccatcaggg ccaccccggt gagcgcgacc agccgcaggg
     4861 cgagcagccc ggccggcagg tcgccgggca ggacaccgga cagcccggcg acgatgccga
     4921 ggaagacggg cccgtacggg gtggtggtgt gccgccacac cggcgcgacc tcgtcggcga
     4981 gcggcccgcc gagccgtgcg ggcccgtgcg cgtacacgtc gatgcccgcg tcgaccatgg
     5041 ccccctgcgc gagatagctg tagacgtccc ggctgaacag gggcggcgcg aggagcagcg
     5101 gggccgccca gacggccagc gtcaccagca gggcacgggg agccggcggc cgtggtccgc
     5161 gcacgacgcg gcccagcagc acccacgcgg cgatcagcag gacgacgccg aagtagacgc
     5221 cgaccagacc gagcgccgcg cccgccgacg agggcgcggg aagctcgcgg acgggaaggg
     5281 ccccggcggt ctcgccgccc agcgcgagga cggcggagcc gacgaggccg agcgcccggc
     5341 agtggcgcag ccggacggga gaagccatgg cccacacgcg gacaggatgt cggcggcgga
     5401 tgaccgggag gggacgggcc gcccgccacg gggcggcctg tgcgtgaccg ccgtgtgatc
     5461 agtgccccgt atgcccccgc gcgacggacg aggagaacaa gaagcgagaa gaaagaggag
     5521 gagcccggtg aagcccggtg aagctgcgcg ccccgcccgc accggcatcc gcatccgcat
     5581 atgcccgggg cggcaccccc gccccgtgcc gaccgttgtc gaagcggacg tggtgagggg
     5641 gcggggacgg gcatcacgaa ggaagagaga cgtcaaaatc ttgccctttt caagatgttg
     5701 acgtcccggt acagcacggc gtcccgcacg gcctgtgcgt gttcaccggc caggccgacc
     5761 atccagtgag acgatccgga gcgcggacgg ggtgtaaggc gccgtatccg ccgcacagca
     5821 ggccggagcc gaggtcaccg gcggacggcc ggacggccgg tgagcccgcg gtttccggtt
     5881 ccgccggggg tccggccggc cggtcacgac ggccggccgc ggtggcggtc cctccgcctg
     5941 gcggcgcatc ggcgattttc agctgtagct ccgtcacggg ccagcggcac atgcttggcg
     6001 gcgtcatcgg ctgtcccggg cacccctccc gtacgagacg agacggagaa cacgactatg
     6061 gcgtccaacc ttctcacccc cgcccgactt gggcagcgca ccttgatcct cacgacggcc
     6121 gcgatcccgt tgaccgggtg gaccgtccac gccgtggcgc tgcaccggcg cctggccgcc
     6181 gcccgccgcg acccgctgac cgggctgctg cggcgcgaca gcttcaccgc caaggcccgc
     6241 cagctgctgc gccgccacgg cgacgacgtg ctggtggtcc tggtcgacca ggaccacttc
     6301 aagaccatca acgacacgct ggggcacgcg gcgggcgaca cggtgctcac cgccacggcc
     6361 gcccggctgc aggcctgggc gggcccccgc gcggccgtcg gccgcctggg cggcgacgag
     6421 ttcgcgatcg tcctgcgtgt cgagcccgga cggcgggagg tgcggctgga gcagctggtg
     6481 cgcatgctgc acacccccgt gagcctggac gacgggcaga cggtcgacgt ggccgcctcg
     6541 gtcggcgccg ccgccccgga cacgctgggt gtacgtgatc tgtcgcagct ccagcgggcg
     6601 gccgacgccg cgctgtacga cggcaagcac tccggccgcg cggtcctcgc ccatctccgg
     6661 cacacgcagg tgccgtccat caacggacgc cgcgccggcc gccccggcac cgccgtctgg
     6721 ggacgcgccg catgagcccg gccgcgctcc gccacggtga cggaacccgc ggcagcaccc
     6781 tccggcagcc gtggcccacg gctgccggac acaccccgac ctgcgccgga acggccgcga
     6841 gcagaccgcc cgcggcccgt gcgcggtcgg ggcccgccgt acgcgggccg gcggaccgtc
     6901 ctgcggccgg cgcgtccggc gcgggctcgc caccgcatca cccggactga cgcgccgggg
     6961 aggccggacc ggcctccacc acgcttcccg ctccggtcgc acgcccggca cgaacgtcgc
     7021 ccacacgctt cgtccaccca cttggatcac cgtgaggaga gcccataatg agccgcataa
     7081 tgagccgaag agaggcccgg cacccgtctt ccggtcactc tccgtactgc tcgtcggggt
     7141 cgaccgaccg ttttcagccg accgcacggc ccggcggcgc cgtgcatcgg cggcagaccg
     7201 cgggtgcgcc ggtgcacccg ggcgaaccgt gcggcgccgg ggtacccggc ggcagcaccg
     7261 gcccacgccc gtgccccgcc ctgccgtcgg ccgctcccaa acctcacaat ctcgcccttg
     7321 tggtgagccg tgcgggcccg ccgccccttc gcggcgccgc ccgctgtcgc ggcaccaccg
     7381 gccgtaccgg ccgtcgccgt ccctaggccc acaacagccg ggcgagcgcc gtccccacgc
     7441 aggcggcggc cagtccgacc gccacgctca cggtcacgtt ggcggcggcc tgccaccggg
     7501 caccctgccg ggcgagggtc agcgtctcgt acgagaacgt cgagtacgtg gtcagcgcgc
     7561 cgcacagccc ggtgccgagg agcagctgca cgcgcgagtc cgcggcgccc gcggcgaccg
     7621 cgccggtgag cagcccgagg acgagcgacc cggcgacgtt gacggtgaac gtgccccagg
     7681 ggaagtccgt gtcgtgccgg gcctgcaccg cgcggtcggt gagataccgc aggggcgcgc
     7741 cggccattcc gccgagcacg acgaggaccc agttcacgac ggcgtcccgt ccgcccggcc
     7801 ggtgcgggcg ttctgacggg acacgaggag ccgtcgggtc gccgacgacg ccgtccagac
     7861 cgccgtgagg gccgccagtg gggtggccgc gaagcaggcc agggcggtca cggcgtgccc
     7921 ggcgtcgagc agccgctcga cgtcgaccgc gtacgtcgag aacgtggtga acccgccgag
     7981 caccccggtc ccgaagaacg gccgcaccag ccgatgagcc gcccacgcct cggtgatcac
     8041 caccatgaac actccgatga cggcgcaccc gacgacgttc acacagaacg tcgtccacgg
     8101 gaatccgccc tgccgcgtgg gccacagcag ggacgcgccg taccgggccg tcgcgccgat
     8161 gcctccgccg agggcgacca ccgccactac ggatgcctgt ccgtgccacg gtgacggccg
     8221 ccgtgcatac ggctgccgta cgggcacccg cacgggcgcg tcgggggccc tctcgggggg
     8281 cggaacgctc atgggggtgc ggctcctact cgccggcccg ggcgccccgg gcatggtcga
     8341 tcgcaagcag ggaccgtcgg cggcaccggt gccacggttc gggtacggcg ggccccaccg
     8401 ccgcgccgcg gggtcccgcg ggcgcgggtc acggccgatg ccagggtaac tcctggggtt
     8461 ccccggcatt cgccctgccc ggcccgcgtg cgcggcgagg ggtgccgcgg cctccctcag
     8521 cctccctggt gctcccccgg cagctcgcac accgcgaccc cgcgttccca cacgctcccc
     8581 aggacgagac ggtcctcggc ccggcacacg ctggtgacca tgcggaaccc ggagcgccgg
     8641 cgcgtgaggt cgtggacgat ccggccggtg tcgtcgaccg cgatcacccc ggcgaacccg
     8701 ccgggccgga agggcgcgcg gagcgcgacc cgggcggcgg cacgccgcac ggcggccggg
     8761 gcggcccggt gcgcggcgtc cagggcggca acgcgcggac cggccagcgc cacccacgtc
     8821 agcccgtccg ggccgcgcca caggttgtcg ggcgcgcccg gcaggtcctc gacgaacggc
     8881 tcgctgcggc ccgtgtccgg cccggtgagc cagtaccggg tgagccgccg ggcaccggtc
     8941 tccgcgatca cgaggaacga ttcgtcaccc gagagggcca gcccgttggc gaactggagt
     9001 ccgtccagga gcacatccgg cgtgtccttc ccgggcgcca ggcacagcag ccgtcccgtc
     9061 cccgagtgtt ccaccaggtc gccgacccag tgctccagcg ggtagcggcg gctggaggcg
     9121 gtgaagcaga cggtgccgtc cggcagggcg accgcgttgc tgcagaaggc cagcggttca
     9181 ccggcgaccg agtccgcgag cacccgcacg gtgccgtccc cgaccgccac ccgcagcaac
     9241 cccatccgcg cgtcgcagac cagcaggtcg ccgtcgggca ggagttcgag cccgaggggc
     9301 cggccaccgg tctccgccag cacctcgacc cgcgtgcgga cgggatcgga gatccggctc
     9361 agccgcagga tgcgcccgtc ctccacaccg gtcagcaccc tgccccggtc gtcggcgacc
     9421 acgtcctccg gtccccggcc gccgatgccc acgtacgcca gcggtacgag cccgccccgt
     9481 gaccgatcca tgtccgcctc ccgatgcgct gcccggttac ggcggcccat cctcgcgtac
     9541 ggcgggtgcg gcgacggccg actccggcaa acccgccacg atcaggcgtc gctcgccgcg
     9601 aaccgtttcc gcgccgcgca ccgttccctc gacgccgtcc gtccccgtac gcggcaccgt
     9661 ccgtttcatg cctgacgcgc ccggcgcacc gggacccgga gatgtacgcc cgcacacgcg
     9721 tccgcgccgt ccgcaccgtc aaccctcgcg cgcccaccgt gagggtgatg ttccttttag
     9781 tgaccattca ctcactatga gtaagcagac ggtcgacggg accgtccgcg accagaggaa
     9841 agggcatccg atggaagagc agaacaccca ggcggtctac gaagctcccg aactgatgga
     9901 ggccggcgac ttcgccgacc tcaccctcgg aggcttcggt cccgacatcg agacattcac
     9961 cattttcggt cttctctgag gttcgcctgt ggtacaggac atgacattcg tgcttctgcc
    10021 cgacagcgac gtggccgacg gagcggcgcg gtcggtgtgc gcgtcacccg gggtccgggt
    10081 gatcgcccat gcctccgggc ggccgtggct ggtcggccgc tggccggccg gccgggtccg
    10141 ggtggccgcg gccgggcagg cgcgcgtggc ggtggccggg ttctgcccgg cctccggcca
    10201 ggagctgacc gcggcggccg ggcgcctgcg cagcctggcc gatctcgacg cggtggcacg
    10261 gcggttcggc ggcagcgccc atctgctggc ctcggtcggc ggccgggtcc gggcgcaggg
    10321 caccgcgtcc ggcgtacggg cggtgttcca cgccgagctg gccggtgtca ccgtcgccgc
    10381 cgaccggccc gacacgctcg cccggctgat cggtgccgag gtggacgacg aggtgctggc
    10441 gctgcgcctg ctgaccccgt acgtgcccca tccgctgctg gaccggccgg tgtggcgggg
    10501 ggtgcaccag gtgcccgcgg gacgctgcct ggtgctgaac cgcgacggtg tggcgcgtac
    10561 cgcgacctgg tggagtccgc ccgagccggt ggttccgctg cgcgaggggg tgccggccgt
    10621 ccgtgaggcg ctgaccgacg cggtgcgcgg ccgggtgcgg gccgccgcgc gggtggtcag
    10681 taccgatctg tccggcggcc tggactcggg tacggtcacc catctcgcgg cgggcgccgg
    10741 cccacgtctg gtgaccgtgc gcattccgca gctggacgcc gccggggacg acgcggagtg
    10801 ggcctcccgt accaccgcac ggctgcccgg agccgagcat ctgctgctgg agtacgagca
    10861 ggcgcccacg atgttcgcag gactggacgg cggtaccggc ctgaccctgg cgagcgagcc
    10921 gccgttctgg gtacgggccg gcgcgcggct cgtcgacatc gccgggcgcg tcgcggcccg
    10981 cgggtcccgg ctccatctgt gcggacacgg cggcgacgag gtgttccacg cctccgccgt
    11041 ctcgttgcac accctggtcc ggtcccggcc gtgggccggc gcgcgcctgc tgcgggaacg
    11101 ccgtgcgctg ggacgctggc cgctggggag cacggtgcgg ggcctggccg actcccggtc
    11161 gttcccggca tggctcgcct gcgccgccga tcagctgccc ggtccgctcc cctccccgtt
    11221 caccccgcac ctgggctgga cgccgccctt gcggataccc gcctgggcga ctcccgacgc
    11281 ggccgccacg gtgcgcgatc tgctgcggca gaccgcgtac gaggagccga ggcccctggg
    11341 ccacggccgc gcggcgcaca ccaccgtgga ggccgtccac cgcgccggtg ccatggtccg
    11401 gtacgcggcc ggactgacgg ccgcacacgg cgtggacttc gccgcgccct acctggacga
    11461 ccgggtgatc gaggcggcgc tcgccgtccg cctgcgcgaa cgtgcccggc cgcgccgcta
    11521 caagccgctg ctcgccgagg ccgtgcgcgg cctggtcccc gaggacctgc tgcggcgctc
    11581 caccaagggc gactacgggg aggacgtctt cgacgggctc caccgccacc gcgcgagcct
    11641 gctgcggctg ttcgacggtt cgctgctcgc ccgccgcggc ctggtcgacg aggccgcggt
    11701 ccgcgccgta ctgagcgccg accacctctt caccctgccc ctgcaagccc tggaacccac
    11761 gctcgcctgc gaggtgtggc tgcgcgccct gcccgccccc gtcccgcagc gggcctgcgc
    11821 cgaaggagcg ctgtgagcac tgtgaccttc accctggcac cggacgtggt ccccaccgac
    11881 accgagcacg gaaccgttct cctcgacgag cggcgcggac gctacttcaa gctcaacgcc
    11941 accggcacgc tcgtcctgcg ggcgctcctg gacggcgcga gcggcgagcg ggcggcggcg
    12001 ctcctccagg agcggtacgg catcgacgcc gagcgggcgc gggccgatgt gtccgcgctg
    12061 atcgacgccg tgtgcgccgc tcggctggcc cgcgcatgag cgcgccgatc gccttcgggg
    12121 aacggtacga cctcccgccg cgccggcgtc tggccgcccg gctggcggtg gcgtcggcgc
    12181 gcgcgctggc ggcccttccg ccacggcgcc tccgcgccgc cctccacctg gtcaggaccg
    12241 gcgcccggcc ggcccgcgcc gcacagacgc tgggcgcccg ggacgcggtc gtggccgtca
    12301 gcgcccgctg cgcgggccgg cactgcctcc agcggtccct ggccaccgcc ctgctgtgcc
    12361 ggatggccgg tacctggccc acctggcgca caggggtgcg taccgctccg ttccgcgccc
    12421 acgcctgggt cgaggccgac ggccggccca tcggggagcc ccatcccgcc ggctactaca
    12481 cccccaccct caccgtcggc ccggcgaacc gctgagccgc ccggccgccg cgcccgcggt
    12541 gtcgtcgtcc cgtgaaccgc gggcgcggag gaggggtccg gccgcacaca gcggccggac
    12601 cctgtccata cgggggctcc tggaccctgc ctggctcagc ggtggcggaa ccactccatc
    12661 gccggcagcg ccctgtcgtc gtacccgaac agggcctggt tctcccagcc gttgccggag
    12721 gtgggatcgg ccgggtccca gccgttgccg gtgacggcgg tccaggtgga ctcccagtag
    12781 aagacaccga gtccacggcc gttgggcacc gcctccacga tgctcgcgac gtccttcatc
    12841 caggcggtct gaccggccgt cgacgccggg tagccggcga cgagctcacc gctgaggtcg
    12901 atgatgttct cgtgggtgtc ctcactgtcc agccggaagg ggtaggcggt ctcggcgacg
    12961 tagaccggct tgccgtagcg ggaggcggcg tcgtcgaggg tggtctggaa gtcgaccagc
    13021 gagccgtgcc agtagccgta gtacgacagc ccgatgacgt cgaacttcac gccgttcgcc
    13081 accgcgttgt cgaaccacca gcgggtgccc gcgaggtcgc cgcccttggc gaggtgcagg
    13141 gcgacggcgg tggaggagtt caccgccttg accgcgctgt agccggagtt gagcaacccg
    13201 gcgagctgcg gccagttgtc ggtggagccc tcgtcccaga gcatgccgcc gttgatctcg
    13261 ttgccgacct ggaccatgtc ggcggtggtg ccctgggcct tgagcgcgct caggacgtcg
    13321 tacgtgtggt tgtacacgtc cgtcttcaac tggctgtagg agtggcccgc ccaggcggtc
    13381 ggcttgctct gggcgcccgg gtcggcccag gtgtccgaat agtggaagtc gaccagcagc
    13441 ttcatgccct gcgccttgat ccgcttggcc agggagagga cgcgggcctt gttgttgtag
    13501 ccgtcggcgg ggttcaccca caccttcacg cgcgcgtagt tctgcccggc ggacttcagg
    13561 atggcgagcg gatcgccctt cgtgccgctg ctggtccggt acgtgccgcc gagcgcctcg
    13621 ctcttggcga gcgacgacac gtccgagccc ttgacggcga gaccggtgcg gcccttggtg
    13681 aacgtcaggt cgtcgacgtt gatccagttg cccgcgtcgg cgtcggagtt gacgctgatg
    13741 gtgcactggt tgttcgtcac cgcgaccgag gccacgatcc ggatccagcc gctcgacgag
    13801 accggcaggt cggtgcgctg ctcggcgccg ccgcagttct tcagggccag gtaggccgac
    13861 ttctggccgc cgcccgagcg cacccaggcg gtgagggtgt agtcgccgtt ggtgaggccg
    13921 gacaggtact ggtacgtctc caccttgtag gcggaggacg accagtgggt caggcggtag
    13981 ctcccgctgc ggccgccggc ctcggtgaac gaggccgcgt tctgcccggc cgccgagtac
    14041 gtcgaccagc cggccggtgt cgcggtcccg gtgccgtcgg actcgaagcc gccgttggtg
    14101 agggtgctcg cggcggaggc actctgtgcg ggcagggcgg tgagggccag cccggcggcc
    14161 aggggcagca gcagggtccg cagtatgcgt ccggaatcgc gtccggaatc gcgtctggga
    14221 tggaacatcg tcgtccgtcg tcccttcgac gtgatggaga tggatgcccc ggaggtggtc
    14281 cgggacaggg ggttttcgcc cccgccgccc ctacccgatc ccgtcccctg ggggctgccg
    14341 cccccagacc cccgctgccg gcctgaacgg cctcgtcctc gaacgccgga cgggctggga
    14401 actttcatcg ccgacctgca cgatgcagtg ctcccgcgtc cgagaagcgg gctggggagc
    14461 cggctccccg gcggcgccgg ggcggagccc ccgtggacct gaatccgggg ctgccccctg
    14521 cacaggtccc gggggccgac tccggacggg gcccgggacg gtccccgtgg atccaggacc
    14581 gagggctgac cccgacgggg cccagggact cgctccccca acggaggtcc gggacggagg
    14641 agccccgcgg atccgggacc gaaggcagcc cccgaacccg agcgagagcc aagcccccgt
    14701 ggacccgggg ccgagggact cccccgctca aaccccggag gctgaccccg acgggaattg
    14761 gggcgaagcc ccacggatcc ggccggggcg aagcccccga acccgggacc gaaggcagcc
    14821 cccgaacccg agcgggggcc aagcccccgt ggacccgggg ggagcagggg gcgcagcccc
    14881 cttggcgggg ttgaaggggc ggagcccctg gggatgggac gggtaggggc ggcgggggcg
    14941 aaaaccgatc cgtgctcagc cgtcgagtcg tacgacccgc acggcccccg cgggcaccgc
    15001 caggtgtccc gcggcgcgtt cacccgtcag tacctcggtg ccgtgcccgt ccaacggcac
    15061 cttggcatcc gaggaactgt ggttgatcac gaacagatag gtgcccgacg cacccgcgcg
    15121 gcggaccacc tcgacgtccc ggggcagatc ggcacgcggc gcgatccgcg cgtcgtcggc
    15181 ggcccagccc agcagggcgt ccaggccctg ggcgtcgagg cgggtcgaca cgtaccaggc
    15241 ggagccctcg ccgagacggt gccgggtgat ggcggggcgg ccggcggtga gcccgtcggc
    15301 gtactcccac acggtctcgg cgccgcgcgg caccacgaac tcggtccaca cgtcgccggt
    15361 gagctcggag ccgtcgggcc cggtgaggcg gacgccgtca ccggcgagca gcggtgagaa
    15421 ctcctcgacg gtcaggccca gcacgtcgcg cagggcgccg gggtacgggc cctcgtggac
    15481 ggcgtcgtgc tcgtcgacga tgccggagaa gtacgagacg acgagggtgc cgccgttctc
    15541 gacgtactcg cgcacgttgt tcccggccgc ctccgtcatc aggtacagcg cggggacgac
    15601 gacaagggga tatgccgaca agtcggcttc cgggtgggcg aagtcgatcg tgaggtggcg
    15661 gtcgtagagg gcctcgtaga aggcgtcggc gcgctcgcgg gcgtcgtggt cctcgctggg
    15721 gcgccactgg aggttctgcg cccaccagga gtgccagtcc cacaggacgg ccgcgtcggc
    15781 gacggtgcgg gtgccgcgga tcgtggcgag ggagtcgagg gacgcgccga gttcgacgac
    15841 ctcgcgccag acccgggagt cggtgccggc gtgcggcacc atcgccgagt ggaacttctc
    15901 ggcgccgcgc cgcgactgcc gccactggaa gaacatggcg ccctcggagc cccgcgccac
    15961 gtgggcgagg gagttgcggg ccatctgacc gggggccttg gcggggttgc ggggctgcca
    16021 gttgacgccc gaggtggagt gctccaggag cagccagggg gcgccgcccg cgacggagcg
    16081 cgtgaggtcg gcggccatgg cgaggttgac gtgggtgcgg cggccgtcgg tgatcaggta
    16141 gtggtcgttg gtgacgaggt cgacctcgcg gccccaggcc cagtagtcga tggagtcgca
    16201 ctggctcagg gcggtcatga agttggtggt gaccgggacg cccggtgaga ggcggtgcag
    16261 gatgtcgcgc tccgccacga agttctcgcg gatggtggcg tcggcgaacc gcttgtagtc
    16321 cagggcctgg ccggggttgc cgacggtggg ggtcacgcgc ggcgggttga tctgctcgaa
    16381 gtccgtgtag cgctgacccc agaaggcggt gccccaggcc tcgttgaccg cctccaccgt
    16441 gccgtacgtg gtcgccagcc agcggcggaa gtgcgcggcg cacgagtcgc agtagcaggc
    16501 cgacacaggg acgccgtact cgttgtgcac gtgccacatg gcgagggcgg ggtggttccc
    16561 gtaccgctcg gcgagctgtg tggtgatgtt cgcggcggca gcccggtagt cggcgttgct
    16621 gtggcagatg gcaccacgtg agccgaactc gtagcgggtg ccgtcggcgg ccacgggcag
    16681 cgcctcgggg tgggcgcggt agaaccacac gggcgggacg acggtcgggg tgccgaggtc
    16741 ggcgcggatg ccgttctcgt gcagcaggtc cagcagccgg tccagccagc cgaagtcgta
    16801 cgtccccggg gccggttcca gcagggccca ggagaagatg ccgacgctga ccatcgtgac
    16861 gcccgcctcg cgcatcaggc ggacgtcctc gtgccagacg ctttccggcc actgctcggg
    16921 gttgtagtcc ccaccgaagg cgagcctggt gaggcccttg gggttggtct ccggcatcga
    16981 ctccggcatg ggtctctccc gtttaatcga tcatttggga acgtgcacac acagcgccga
    17041 cggcgcggag ccaacataac cgcacagcaa caaccattga caagtgtcga gagtgtttct
    17101 ctactgtgaa cgctcacaga agcatggcag gttctcgcag caaggcggga gccacggtca
    17161 ggggagattc gatccatgcc caccaacacg aagcaccgcc gctttgtggc caccgctgtc
    17221 gccgtgacac tcggcgccac cacgctcgcg gcctgcggct cgtccgacga cgacagtgat
    17281 gcgcagtccg ggcccgcgaa gctgacgtac tggacctgga cgccgggcat ggacaaggtc
    17341 gtcgacctgt ggaacaaggg ccccggcaag gagcagcaga tcaccgtcac ggtgaagaag
    17401 caggcctccg gcgacaccct cgtcaccaag atcctcaccg cgcacaaggc gggcaagggt
    17461 cccgacctgg tgcaggccga gtaccaggcg ctgcccacgc tggtcagcaa tgacgcggtc
    17521 gccgacatcg cgggcgaggc cggcgaggcg gagggcgact tcgccgaggg cgtctggcag
    17581 cagacgacgc tgggcacgga cgcggtctac gcgatcccgc aggacatcgg gccgatgatg
    17641 ttctactacc gcgaggacct gttcaaggag tacggcctga cggtgccgac gacctgggac
    17701 gagttcgccg agaccgcgcg gaagctgaag gaggaggctc ccgatgtgga cctgaccacc
    17761 ttctccgcca acgactccgg actgttcgcg ggcctcgccc agcaggctgg cgccaagtgg
    17821 tggaccaccg agggccagaa gtggaaggtc ggcatcgacg acgcggcgac gcagaaggtc
    17881 gccgacttct ggggcggtct cgtcgaggag ggcgccatcg acaaccagcc gatgtacacc
    17941 cccgcctgga acaaggcgct caacaccggc aagcagatcg cctgggtgag cgccgtgtgg
    18001 gcgccgggca ccctgaccac cgccgccccc gacaccgcgg gcaagtggaa gatggcgccg
    18061 ctgccgcagt ggtcgaagag cgaggacgtg accggcagct ggggcggttc ctccaccgcc
    18121 gtgaccacgg actccaagca caaggaggcc gccgccaagt tcgccacctg gctgaacacc
    18181 gaccaggagg cgctggccgc gctggccaag gagggcggca tctacccggc cgcgacgacc
    18241 gcgcagctca gcgaggcgtt cgcggagccg ccggcctact tctcgaacca gccggacttc
    18301 tacacccggg ccgccgccat cgccaagacc acggcgccgt cggcgtgggg tcccaatgtg
    18361 aacgtcgcgt acaccacctt caaggacgcg ttcgccgccg ccgcgaagga caggtccgac
    18421 ttcggtgccg ccctgacgac gatgcaggac gagacggtcg ccgacctgga gaagcagggc
    18481 ttcgaggtcg ccgagtgacc agcacgcgca aggagccgtc cggggtcgtg gggaccccgg
    18541 gcggccgccc caccccggtc gcgcgtacgt ccggcggccg tccctccccc gcccgtgccc
    18601 gctcccgcgg gcgcggcggc gcaccgtatg tcttcctgct cccggcgacc gtcctgttcg
    18661 ccctcttctt cgcgctgccc atcggctacg cgctctggct gagcctgcac aaggtcgagg
    18721 tcaagggcct cggtctgggc gcgggggcgc ggcaggaggt gtgggccggc ctggagaact
    18781 acgccgacgc cctgaccgac tccgaactgc tggccggcgc gctgcgcgtg gtcgggtacg
    18841 gtgcgatcgt ggtcccggtg atgctgggcc tggcgctggt gttcgcgctg atgctggaca
    18901 gcgagaaggt ccggctgacc cgcttcaccc ggctcgcgat cttcctgccg tacgccgtcc
    18961 cgggcgttgt cgcggcgctg ctgtggggct tcctctacct gccggacgtg agccccttct
    19021 acttcgtcct cgacgagctc gggctgccgc agccggacct gctggacggc gggccgctgt
    19081 acctcgccct gtcgaacatc gcggtgtggg gcggcaccgg cttcaacatg atcgtcatct
    19141 acacctcgct ccagtcgatc ccgaacgagg tgtacgaggc cgcgcggctg gacggcgcca
    19201 caccgctgca gatcgcgctg cggatcaaga tcccgatggt ggcgccgtcg ctggtgctga
    19261 ccttcttctt ctcgatcatc gcgacgctcc aggtgttcag cgagccgacc accctcaagc
    19321 ccctcaccaa ctccgtctcc acgacgtgga gtccgctgat gaaggtgtac caggacgcct
    19381 tcggcaaggg cgacatccac gcggccgccg cgggcgcggt gctgatcgcc gtggccacgc
    19441 tggtcctgtc cttcggcttc ctgcgggccg ccaactcccg ttccaagcaa gaggaagcac
    19501 gatgacccag caggaggcag cacgatgagt actcttgccg tccgcaagtc cgcaccggcc
    19561 gcggggacca cgcccggcac cgcccagggc ccgcccgcgc gccgccgccg tatcgccctc
    19621 gtcccgacgc tcaccctggt gctgggcgcg ctgtactgcc tgctgccggt ggcctgggtg
    19681 gtgatcgcgg ccaccaagtc gggccgtgag ctgttctcca cgttcacctt cctgccgggc
    19741 accggcttcg cggacaacct gtccgacctg aacgcctacc gcgacggcgt ctactggaag
    19801 tggatgggca actccgcgct ctacgccggc ctcggcgccc tgctgtccac cgccgtctcc
    19861 gcggtcagcg gctacgcgct cgcgatctac cgtttccggg gccgcgagac cgtcttcagc
    19921 atcctcatgg cgggtgtgct gatgccaccg gtcatcctcg cgatcccgca gtacctgctg
    19981 ctggcgaagg cggacctgac ggactcgtac tggtccgtgc tgctgccgct ggtcctctcc
    20041 ccgtacggcg tgtacctcgc ccgcatctac gcagccgccg ccgtgcccgg tgacgtggtg
    20101 gaggccgggc ggatggacgg ggcgggcgag tggcggatct tcacgcggat cgcgctgccg
    20161 atgatggtgc cggggctggt gacggtcttc ctgttccagt tcgtggccgt gtggaacaac
    20221 ttcctgctgc cgtacatcat gctcagcgac gacgagaagt tcccgatcac gctgggtctg
    20281 ttcacgctgc tggaacaggg atccaacacc ccggcgctct acaccctcgt catcacgggc
    20341 gcgctgctcg cggtgctgcc gctgatcgcc ctgttcctgg cggtccagcg gttctggagc
    20401 ctcgacctgc tgtccggggc cgtaaagtca tgaccatgag caacacgggg ggccggcgca
    20461 ggccgccgac gatccacgac gtggcgcgcg aggccggggt gtcccggggc acggtgtcac
    20521 gcgtcctcaa cggcggccac tacgtcagcc ccgcggccca ggaggccgtc aacgcggcga
    20581 tccgcaagac gggttacgtc gtgaaccggc acgcccgctc actgatcacc gggcggtcgg
    20641 actcggtcgg cttcctgctg acggagcccc aggagaggtt cttcgaggac cccaacttca
    20701 acgtcctgct gcggggctgc acccaggccc tggccgccca cgacatcccg ttgctgctga
    20761 tgctggcggg cacgaaggac gagcggcggc gcatcacgcg gtacatcacc gccggacacg
    20821 tcgacggggt gctgctggtg tccagtcact ccggggaccc ggtcgccgag gagctgcgcg
    20881 aggcgggcgt gccgctggtc gcgtgcggca agcccatcgg gctcggctcg aaggtcagct
    20941 atgtggcggc ggacgaccgg gacggcgccc gcgacatggt gcgccatctg ctgtcactgg
    21001 gccgtcgccg catcggcgtg gtgaccgggc cactggacac cccgggcggt gtcgagcgtc
    21061 tcgcgggcta ccgggaggtg ctcaccgagg cgggcgtcgg cgtggaagag cggctgatcg
    21121 tctccggcga ctacagccgc gccagcggtg aggcgggggc ggaacggctg ctggcacagg
    21181 caccggacgt ggacgcggtg ttcgtcgcgt cggacctgat ggcacagggc gtgctcagcg
    21241 cgctgcgccg ggccggccgg cgggtccccg aggacgtggc cgtgggaggt ttcgacgact
    21301 cccccgccgc cacggccgcc accccggccc tcaccacgat ccgccagccc tgggaccgga
    21361 tcagcaacga gatggtgcgg gtgctgctgg cgcagatcgg cggggaggac ccggcggcgg
    21421 tgatccttcc gacggaactg gtgcggcggg actcgacctg aggccgcggg ggcccagggc
    21481 cggaagccgg gaccccgcac gtcgttgcgc acgcattagt tgcatggtca acgaacatgc
    21541 ccaggtctgt taccgtgcac gcatggcagc caacacggcc ggcacccggc tcgaggatcg
    21601 gtggcgggac atcctgtcgg tgcacgcgcg caccatgtgt gagatcgacc gcgcgctcca
    21661 cccgcacggc ctcggcgcca gcgacttcga ggtgctcgac ctcctcgtct ccgccgcggc
    21721 ggagaactcc ggggaggcgt gccgcgtaca gaacatcgcc tgccgggtgc atctcagtca
    21781 gagcgcgctg tcccggctga tcggccggct ggagaaggac ggcctcgtgg aacgctcgat
    21841 ctgcgaggag gaccggcgcg gggtgtgggt cgccctcacc gagaagggac gcgacctgca
    21901 cgcccgggtg ctgccgctgc agcgcgcggc cctgtcccgc acgctggacg gctgaccgcg
    21961 gccggctcgg ccgtacggcc tcatcagtcg tacggcctgg ccagcagggt gcggaccccc
    22021 tggggggtca gcgtcaggcc gtagggagag gtcgcgtcta tggtgagcga cagatcgccg
    22081 tcgggccact gcgcggcgag cgcgcccagc ggcaccaggc ggtagcgctc cacggacggc
    22141 agcagccccg ccatctccgt ctccgaggtg aagacgggca ccacctgttc gcctcccggc
    22201 tgctccagta cgggcagcgc cacgaccgtc ggatcggtgg cgtcctcgtc actggcgtcg
    22261 tccggcacgg ggatcagtac gtcgctgtgg gccagcgtgt cgagtgcgac cgcgtcgccg
    22321 gtgtcctcgg cgagcgtcgt cagcgcccgc tgcgccgcgg tcacggactc gggcgcgatg
    22381 tggtcgtacg cggtgtggtc gtacgggggt gtgtccatgg cggatcccgg ggtagtggcg
    22441 aaacggacca cccgggacgg ggtccgttcc gggcgcaacg ggggtcgcgt acccgagcgg
    22501 gcgacgggca tgcct
//
