LOCUS       NZ_BMVW01000018        21086 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence18, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000018
VERSION     NZ_BMVW01000018.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 190557)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 85495
            Orig. end                         :: 106581
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(440..454)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     gene            582..2687
                     /locus_tag="IE242_RS31800"
                     /old_locus_tag="GCM10010365_65210"
     CDS             582..2687
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040407.4"
                     /locus_tag="IE242_RS31800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65210"
                     /product="hypothetical protein"
                     /protein_id="WP_189865532.1"
                     /transl_table=11
                     /translation="MIDGTIPPRHVLVVGAQCEDARLEGLEDAARALHTALVDPGLGGC
                     VDRGEESLLIGTGLGRERVHAAVVRAARAAQRDRGSLVLALIGHGEGTEGTPLHFVVSG
                     RTNGPELDNMNVPDLLGSVANHPGVTGLLTIVDTCLAGGAVPDASRITMGRQEGGVRFG
                     LLFAAAAKEEAYRMRLSKGLVRLMEEGLPGAGDLLTVDERLLEKLREEIEGQQLGGHVF
                     NGAPAFGDSLWLARNRAAALGHSLGAIAGKAVQDAVRRIDTNLRLTTEEEITAWLREHP
                     PAPGDRSWFAVRRLQEVQAELAAGRKTLRVVNKVFGPELTEESLQLAGLLAGLPLTWVR
                     HEPPRALRDLVEYAAHHGDSMEGAHRALARLVAALAHVTGHGDRLPGDVIGWAQDLGLT
                     ATVNSRLRELTGQPHGERAPRLVLVLVDDGGESIVRVDAWLLYGRAVLAHQGFPCPARP
                     DGTTKALAEALAWAGPWANVAGGRLSHIDVAAPTLTLLDRPPEDQIVRKQRLGANYTVT
                     TRWSGLLTPPPDFAIDDMLQVGEQLLASMEEQRRACQSDDEPPGPAWLLEQDLETVEQL
                     QELLVDHGCGQRVWAVTSLPRTDWDFMAQELLEHTPALVWPRQKDIGDAQALQASVRKH
                     WQALPQQIAHAYRKQLSRTVQDPDGDLGPLAAVRTAWHDHDWQAFCQRRARAVVRAPHE
                     TTSKERA"
     gene            2684..3661
                     /locus_tag="IE242_RS31805"
                     /old_locus_tag="GCM10010365_65220"
     CDS             2684..3661
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983775.1"
                     /locus_tag="IE242_RS31805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65220"
                     /product="AAA family ATPase"
                     /protein_id="WP_189865534.1"
                     /transl_table=11
                     /translation="MSWTPYYKGTGVPPENPAELPAPPPWRTPAQRQETDRRTDPATTY
                     RPVPGLVDAVNAALHLRRPLLLTGRAGSGKSSVIRQIAAELGLGEVLHWHITSRSTLAD
                     ALYRYDALGRIHAHNLRMLDGTTRPAGNDHEDEIGEFVQLGPLGTALLPGGRPRALLID
                     EIDKSDLDLPSDLLDVLERGGFEIPELARHPEPEITVRTADKDRTHTVERGRIQCDEFP
                     VIVLTSNGERDFPAPFLRRCVRFDMPPLSQEALTEIVAAHLDELDAATTDSLVKTFLDR
                     LNAGESVAVDQLLSAVYLLRGDRIPDAGQRRSMEELLLRGLGRG"
     gene            3654..8906
                     /locus_tag="IE242_RS31810"
                     /old_locus_tag="GCM10010365_65230"
     CDS             3654..8906
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF041121.1"
                     /locus_tag="IE242_RS31810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65230"
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_189865536.1"
                     /transl_table=11
                     /translation="MAESAAARLARLALAGEGEGEGDGDIDVKDLLDALLLASALAHRD
                     GPPGSHSSDAPDDTPQPQDGDAAGTSSPAKGLPVPADDETDDASQPAASVWLEDQEGAL
                     RVPGKRLSVGRAAALPRALDIGRALRPLRRPWLSGVRGRLDVDATVEYYTRTGMLVPRL
                     APAPEPWLEAIVVLDRGTAMAVWDETVRAFTGTLRALAAFRHVRVWHLEHPPGGTPVLY
                     DHHGRALPMDPDAARHTQPARRLLLVVSDCAAPAWRQDALWRTLHVWGRTAPVALVNPL
                     PKRLWQRSGLDLPRTTATAGIPASPGRLLSYRPPRLLRMTAETKPWQALPVLQFDPGQV
                     LAWTRTLMRTDPSGCEAVLVPATGRPPLRPGRAAPAGRPGAASPEDQVAAHAEAFTDDR
                     RSPAVRLALAASPLGSFTLSVLGVLRERLVPEADLADIAEFLTAGLLTVTRQDAADPLY
                     RFHPAAAAHLTGLLTRDQLWDTHFALTDHLDSHPQAPHGIVTVLHAPEGEEHLPAGLRP
                     IAHAAAATARLLGVEPTEPLPGGVRPAGPASPSPPHTDVAEDDAPAPEPPELVLTGHRG
                     AVRDLSFAPDGARIATAGDDGTVRIWDLATGARLVELAGQDGRIRCVAHSPDGSRIATV
                     GTRGVARVRDLTTLRDTSVLMGEVSSMAWSPRGDHLAVGTADGTTHLVAGEELRYLEPG
                     HSERVTAVAFSPDGAHFATAFMGTTVHIWEVSSGSLVVVLGHEGSVTSVAYSPDGTRVA
                     TGSSDSTARIWDAATGRCVAVLTGHSGSVRGVAFSPDGTHIATAGQDGTVRVRDVVSGA
                     ELVGIPHESPVTAVAYAPDGTLLATAGEDGIAQLWRMRPPPHRDPSQNLDPEEGTASPP
                     EGGGRETSDIASRLARANDLTGPELRAVVEEGIGWARTRVREAGCTAVLKPLLECTGLT
                     TAEREVSVALAGEWLEHHVFAGYASYLIRPLLERPDLTEGQLRKAVVLTGEWLRAHGRE
                     YAADFVIRALLERRDLTEGELRGAVVFAGDWLKEHGRRHAADFLVRALLSRDDLTAAEN
                     RTAVDFAAVWLRRRQRAPESSFVLASLLSRADLASALVRETVSTALEWLGTHGQTPAAC
                     FVLRALLDRTDLTSDDAVRAASSALGWLEVHPSGRNASFVLTPLLARAELRGEQADHAL
                     SAAMNWLEGAGGTNEANFVLRQLLRRRDLTDGLTREAVARSLTWLRLHGHTVQAGFVIG
                     PLLLRQDLTPDEAEQATALALHWARRHRGAPEAEFPLRSLLQRSDLSEAAAETLTSLAA
                     DWLDAHRDSPRASHVLTALLGRTDLDDEQSGRIREAATDWLRTNGDLSEAARVLNARLG
                     RSGGTDEQAREPVADALSYVRRHIGETANLQLLETLMKSGKLAAEDTRDIVSITLDWVD
                     AHVGEREVAHHLRLLLAAGDVTDQALDRTVALTARWLEHNVTSPGAWSVLDGLLAREEV
                     TGDRLRAAVAFAGLWMRDHASTMEAQFILSRLLLRADLTPGEQRDAVAASFAWLRLHGT
                     TWGAQFILPPLSAHPSLTPDQVDQAFECSRDWLLRHPAQHSTQDVMEAVLLRSGLTAAQ
                     VRTVASAVLRWSTDHADETNSRRMLKTLLSRADLPEDILTEAVGLAYDGLSADPTALDA
                     GYLLDALLRVQDLPADQLTPTLTWAFQWLHEHMPAWRSRMVLRALLGRNSLTPEQARLV
                     MRSAVVWLREHAAASASGGSRRAAREMLELLLAREDITEDIARQAGEFAYLRR"
     gene            complement(8985..9893)
                     /locus_tag="IE242_RS31815"
                     /old_locus_tag="GCM10010365_65240"
     CDS             complement(8985..9893)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058648.1"
                     /locus_tag="IE242_RS31815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65240"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_189865538.1"
                     /transl_table=11
                     /translation="MTSNASTPSATNSKNVKSATTAPVPPQSTYQNRVAAYWNAEENPV
                     NLELGRIDDLYHHHYGVGNVDWSVLDETGLVRRRERITAELHRLEQAQAELLASHLGPL
                     SPADRVFDAGCGRGGGSVVAHLRYGCEADGVTISGKQADFANEQARRRDIADKVRYHHR
                     DMLDTGFASGAYAASWNNESTMYVELDLLFAEHARLLRRGGRYVTITGCYDDTYGRASR
                     EVSLINAHYICDIHPRSEYFRALARNRLVPVHVQDLTSATVPYWELRKEADHLVTGIED
                     AFLTAYANGSFQYLLIVADRV"
     gene            complement(10001..11086)
                     /locus_tag="IE242_RS31820"
                     /old_locus_tag="GCM10010365_65250"
     CDS             complement(10001..11086)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446258.1"
                     /locus_tag="IE242_RS31820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65250"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_373299639.1"
                     /sec_met_domain="T1TS (E-value: 4.1e-56, bitscore: 184.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSDATPVSGTPPEPGAPRAWRLPGPPRPPRITPARRSGAIPGLL
                     YRPAVPADPEKAAEVDRRLDAWARELELFPEAWTGDFTGFQFGRAVALQHPGAADLDRL
                     TTAGKLLLAENVVDSCYCEAEEGRGGSPRGLGGRLVMAQSAIDPYHGVPELEEEWRRGV
                     RADGPLRSYHWALKDYAAFATPSQTGRFVHDIARLHLGYLAEAAWAEVRYVPRVWEYLV
                     MRQFNNFRPCLSIVDAVDGYELPEPLYARPETQRITALACNATTIVNDLYSFTKELADP
                     AHLNLPRVIAANERCGLKAAYLEAVEIHNRIMAAFEAESAVLSAGSPLVGRYAAGLAAW
                     VSGNHEWHATNTHRYHLPNYW"
     misc_feature    complement(11372..11386)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.23"
                     /tool="antismash"
     gene            complement(11380..12831)
                     /locus_tag="IE242_RS31825"
                     /old_locus_tag="GCM10010365_65260"
     CDS             complement(11380..12831)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326604.1"
                     /locus_tag="IE242_RS31825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65260"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_229859707.1"
                     /transl_table=11
                     /translation="MTVPDSSPENTPDSTTGPTGPDADAQQFTSLGTEAARRLATTTKS
                     EPQMQAITSRWLLKTLPWVDVKGGTYRVNRRLQLRIGRGRVQFEQNGADHIKVIPRTLT
                     ELPALRGYSDMDVLNELASRFRLRTVRAGQVLFEAGQPVTEAYLIVHGRFTRFATGKYG
                     EEEVTGVVTDGEGLGDEAVGRADPLWLGSVRAETPGTVMALPWDVLEDFVERAPSLAAH
                     LDAFAERQSKPMNRKGEADVPVQAGHVGEPVISGGFVDYDLAPREYELSLTQTVLRVHT
                     RVTDLFNDPMNQTEQQLRLTVEEIRERQEWELVNNREFGLLHNIDHGQRISTFSGPPTP
                     DDLDELLTMRRKTRLFLAHPKVIAAFFRQCNRRGLVPGTVNVDGHEVPAWRGVPVFPCG
                     KIPISPQHTSSIIALRTGEKDQGVVGLHQTGIPEEYEPGLNVRFMGIDKAAIMSYLVTA
                     YYSMAILVPDAAGVLENVQVGWMPE"
     misc_feature    complement(13028..13043)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(13508..14215)
                     /locus_tag="IE242_RS31830"
                     /old_locus_tag="GCM10010365_65270"
     CDS             complement(13508..14215)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327391.1"
                     /locus_tag="IE242_RS31830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65270"
                     /product="HAD family phosphatase"
                     /protein_id="WP_189865542.1"
                     /sec_met_domain="HAD_2 (E-value: 2.5e-34, bitscore: 112.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGILGSISVVFDLDGTLVDSEPNYFEAGRQTLAEQGVTDFTWADH
                     ERYIGISTQETIALWQERYGLEAPAEELLADKNRRYLELARASTRVYPEMRAFVHLLAK
                     EGVPMAVASGSSREAIEAILAGTGLADRLKTVVSADEVPRGKPAPDVFLEAARRLGAAP
                     ADCVVVEDAAPGVAAAHAAGMRCVAVPYLAAQADAPAFATAAAAGLLVRGGQSAFTARG
                     AFDWLVRSARRFT"
     gene            complement(14253..14729)
                     /locus_tag="IE242_RS31835"
                     /old_locus_tag="GCM10010365_65280"
     CDS             complement(14253..14729)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135128.1"
                     /locus_tag="IE242_RS31835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65280"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_189865544.1"
                     /transl_table=11
                     /translation="MAVDELDTRILRLLLEQPRTSAREYARILGVARGTLQARLDRLER
                     EGVITGTGPSLSPAALGHPVLAFVHIEVTQGHLDDVGEALAAVPEIVEAFSITGGGDLL
                     TRVVARDNAHLEDVIQSLISLPGVVRTRTEVALRERVPHRLLPLVEAVGRAAGG"
     misc_feature    14826..14841
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(14826..14844)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.36"
                     /tool="antismash"
     misc_feature    complement(14828..14841)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.3"
                     /tool="antismash"
     misc_feature    14829..14842
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.73"
                     /tool="antismash"
     misc_feature    complement(14829..14844)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.77"
                     /tool="antismash"
     misc_feature    complement(15017..15031)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.44"
                     /tool="antismash"
     gene            15025..16512
                     /locus_tag="IE242_RS31840"
                     /old_locus_tag="GCM10010365_65290"
     CDS             15025..16512
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174660.1"
                     /locus_tag="IE242_RS31840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65290"
                     /product="FUSC family protein"
                     /protein_id="WP_189865697.1"
                     /transl_table=11
                     /translation="MFMAPDPGLLRLRVSLRAVLGIGLAVAASELAGLSLTASVTAGLA
                     ALLALFTVADATVRGQAVTTALLPVAGFPVLALATALHGTPALRDACWLAVVFCGVYAR
                     RWGPRGNALGIFAFMTFFVTQFLHAVPGQLPELYGAIALALAAASGVRFGAWCIERRTP
                     PAAVLPPLDGRGAARPTTRQAFQATVACAFAMTAGQVLSHERWYWAVGTAWWIFVNTAS
                     RGETLVRGFRRVVGTVTGIAAGLLVAVPLDGAPAPTAVLVAVCVFGIFYTAPLSYSWMM
                     FFVTVMAGLLYGLLGVLHPGLLALRFTETAAGAAGAALAVALVLPVTTHAVTDRWVRRA
                     LHAVHGCTAVAARRLAGDAAADPAPRAAELEALLGRVRLSVAPLVHPLNPLRERKRRAR
                     QVLALLDDCARETRGLVAVAADPDASHDARLTAACLRVETAVEALVGAVPERAVPAHAG
                     APGHHPGAEQALAHLHALERALTALAAPLRQSPLAGA"
     misc_feature    16596..16611
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.63"
                     /tool="antismash"
     gene            16673..17770
                     /locus_tag="IE242_RS31845"
                     /old_locus_tag="GCM10010365_65300"
     CDS             16673..17770
                     /EC_number="3.1.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241332.1"
                     /locus_tag="IE242_RS31845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65300"
                     /product="lactonase family protein"
                     /protein_id="WP_189865546.1"
                     /transl_table=11
                     /translation="MGPRQRKGTAVAEEDAHGRAGRAYIGSFTTAGGPGIVVAAVDGES
                     GTLTPLGGVDGVDGVPNPSYLALSPGGDLLYAVSETAEGAVAAYRLTGDSLEPAGPPVP
                     VPVPGSGPTHLGLFAGHVLTADYGSGSITAVPLRTDGTLAETASGVLRHTGSGPHPERQ
                     RGPHAHQVQADPGGHWAVGVDLGTDSVLVCALDAGRPVLHGETALRPGSGPRHLAFHPD
                     GRHAYVVHELEPIVTVCRWDTVTGLPIPLGEVALLPDTPDGDAYPSGIAVSPDGRFVWT
                     ATRGQDVLSVLAVDGDGETLRPVETVPCGGHWPRALTVSGCGRFLYVANERSGDVTWFA
                     VDPDTGVPRRSGSVAVPAASCVVLG"
     gene            complement(17890..18813)
                     /locus_tag="IE242_RS31850"
                     /old_locus_tag="GCM10010365_65310"
     CDS             complement(17890..18813)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003977715.1"
                     /locus_tag="IE242_RS31850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65310"
                     /product="sirohydrochlorin chelatase"
                     /protein_id="WP_189865548.1"
                     /transl_table=11
                     /translation="MSSPTGPASGLPVRMPRPRQPGRHRRPEPLVAPEGAPALVLAVPG
                     TPSAATRSLAEEVVSIARSELPGLDARIGYLDGNGDEFPTLQSVLARVGEERTARYEQA
                     RAAGMDVKEPDGPVGVVVPLLAGPDGSLLRQVRQAVMESRVAAELTDVLGPHPLLAEAL
                     HVRLSEAGLARADRARLFTVATAADGIILASVGGDEAVQAAGITGMLLAARLAVPVMAA
                     ALDEDGSIASVAEQLRSSGSQQLALAPYLIGPEIDAGLLDAAAKEVDCATAEALGAYPA
                     VGKLVLSKYMTALGIAPQQPQGMPVR"
     misc_feature    18884..18898
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.06"
                     /tool="antismash"
     gene            complement(19048..20001)
                     /locus_tag="IE242_RS31855"
                     /old_locus_tag="GCM10010365_65320"
     CDS             complement(19048..20001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474881.1"
                     /locus_tag="IE242_RS31855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65320"
                     /product="N-acetylglucosamine kinase"
                     /protein_id="WP_189865699.1"
                     /transl_table=11
                     /translation="MLAVDSGGSGLRVVLAAGGEVLADPLVSGEPVRIGARGVDAGHLL
                     EQLLPMARQLIGAAGAGPPRAVVVGATGFATLGDRMRAELPPALTREFGAPRIALVADA
                     VTAYTGALGPHAGAVVAAGTGLIAIGTDLERWRRADGWGHLLGDCGGGAWIGRAGLEAA
                     LRAHDGRPEGSALLLVRAEEMFGPVSELPARLYPRTDRPAVLASFAPQVAACAGHDPVA
                     ADILRAAARHMADSAAAVCPADGEPLIALTGGVFHMGEPLLAPLELELKERLPHARRVP
                     AEGDPLHGAVRIATELATGALALPRDARMLHEVAGN"
     gene            complement(20352..21029)
                     /locus_tag="IE242_RS31860"
                     /old_locus_tag="GCM10010365_65330"
     CDS             complement(20352..21029)
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013005632.1"
                     /locus_tag="IE242_RS31860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_65330"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_189865550.1"
                     /transl_table=11
                     /translation="MAPRPLHEIVEAGWAKALEPVTGRIAEMGDFLRAELAAGRTYLPA
                     GPNVLRAFQQPFDDVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPLPGSLINIYRELQAD
                     LELPQPSNGDLTPWTQQGVLLLNRALTTAPRRPAAHRGKGWEEVTEQAIRALVARGRPL
                     VSILWGRDARNLRPLLGDYPSIESAHPSPMSADRGFFGSRPFSRANDLLLRQGAQPVDW
                     RLP"
ORIGIN
        1 gctcagggcc ccggcgagac cggccgccgg ttggtcggcg tcacgacgac catgctgcgt
       61 ctgccgggac tgcggcaggc ggcgcagtgg atgaacggcc gggccgtcct gctccagctc
      121 gcccaggtcg gccgctatct ggagcgccgg gggaagaagg cgtccctggg cgccgccgtg
      181 cgtgcccggg tgctcgacgg cctggatccc gagcggcctc tcgtggtcgt ctcgcacagt
      241 ctgggcacgg tcgtcgccta cgaggcgctg cacgagtacg agggagaggt gtccctctgg
      301 gtcaccctgg gttcgccgct ggccctcggg gcggtggtgc tggaccgact cgtgccgagc
      361 ccggcacgct gccccgagaa cgtcgcttcc tggctcaact actgggaccg ggacgacatc
      421 gtcgtgggcc ggccgcggct ggccgactgg atccgcccca gcgacagcgg ggtcaaggcg
      481 gtgacggccc gtgtcgactc ccgcgggctg tggacgcaca ccgccacgaa gtacctggag
      541 cacggctccg tggcccgccc ggtgatcgag gctctccggc cgtgatcgac ggaacgatcc
      601 cgcctcgtca tgtgctcgtc gtgggcgcgc agtgcgaaga cgcccggctg gaagggctgg
      661 aggacgccgc ccgcgctctc cataccgccc tggtggaccc cgggctgggc ggctgtgtgg
      721 accgtggcga ggaatccctg ctgatcggta cgggactggg cagagagcga gtgcacgcgg
      781 ccgtggtgcg ggccgcccgg gccgcacagc gcgaccgggg gtccctggtg ctggccctca
      841 tcggccacgg cgagggcacc gagggcactc cgttgcactt cgtggtctcc ggccggacga
      901 acggcccgga gctcgacaac atgaacgtgc ccgacctgct cggctcggtc gcgaaccacc
      961 ccggcgtcac cggtctgctc accatcgtcg acacctgcct ggccggcggc gcggtgccgg
     1021 acgcctcgcg gatcaccatg ggccggcagg agggcggcgt acggttcggt cttctcttcg
     1081 cggccgccgc gaaggaggag gcctaccgga tgcggctgag caagggactc gtccgcctga
     1141 tggaagaggg cctgcccggc gccggggacc tcctgacggt cgatgagagg ctgctggaga
     1201 agctccgcga agagatcgag ggccagcagc tgggagggca cgtcttcaac ggcgcgccgg
     1261 ccttcggtga ctccctctgg ctcgcccgca accgcgccgc cgccctgggc cactccctcg
     1321 gagccatagc gggcaaggcg gtgcaggacg ccgtccgccg gatcgacacg aacctgcggc
     1381 tgaccaccga ggaggagatc accgcctggc tgcgggagca ccctccggca ccaggtgacc
     1441 gttcctggtt cgccgtccga cgactgcagg aagtacaggc cgagttggcg gcaggccgta
     1501 agacgctgag ggtcgtgaac aaggtgttcg gaccggagct gaccgaggag agcctgcagc
     1561 tggccggcct gctggcgggg ctgccgctca cctgggtgcg ccacgaacca ccgcgggccc
     1621 tgcgggacct ggtcgaatac gccgcgcacc acggggattc catggagggc gcccatcgcg
     1681 ccctggcccg cctcgtcgcg gccctcgccc atgtgacggg acacggggac cgcctgcccg
     1741 gggacgtcat cgggtgggcc caggacctcg gactcactgc cacggtcaac agccgcctgc
     1801 gagagctgac cggccaaccc cacggcgaac gggccccccg gctggtcctg gtgctcgtcg
     1861 acgacggggg cgagagcatc gtccgcgtgg acgcctggct gctctacggc cgtgccgtac
     1921 tcgcccacca gggcttcccc tgccccgcga ggcccgacgg tacgacgaag gccctggccg
     1981 aagccctggc ctgggccggc ccgtgggcga acgtcgcggg cggacggctc agccacatcg
     2041 atgtggccgc gccgaccctc acgctgctgg accgccctcc ggaggaccag atcgtccgca
     2101 aacagaggct gggcgccaac tacaccgtca ccacacgctg gtccggcctg ctgacgcccc
     2161 cgcccgactt cgcgatcgac gacatgctcc aggtgggcga acagctgctg gcctccatgg
     2221 aggaacaacg acgggcctgc cagagcgacg acgagccccc cggtcccgcc tggcttctcg
     2281 agcaggacct ggagaccgtc gagcagttgc aggaactgct ggtcgaccac ggctgcggac
     2341 agagggtgtg ggccgtgacc tccctgcccc ggaccgactg ggacttcatg gcgcaggaac
     2401 tcctcgagca cacacccgcc ctggtctggc cgagacagaa ggacatcggc gacgcccagg
     2461 ccctccaggc gtccgtccgg aagcactggc aggccttgcc gcagcagata gcccacgcct
     2521 accggaagca gctgagcaga acagtccagg accccgacgg cgacctcggc cccctggccg
     2581 ccgtgaggac ggcctggcac gaccacgact ggcaggcctt ctgccagaga cgggcccgag
     2641 cggtcgtgag agcaccgcac gagacgacgt ccaaggagcg agcatgagct ggaccccgta
     2701 ctacaagggc acgggagtcc ccccggagaa ccctgccgaa ctgccggcgc cgcccccgtg
     2761 gcgcaccccc gcacagcggc aggaaacgga ccggcgcacg gatcccgcca ccacctaccg
     2821 cccggtcccc ggcctcgtgg acgcggtcaa cgccgccctg cacctgcgcc gccccctgct
     2881 gctgacgggc agggcgggct ccgggaagtc cagcgtcatc cggcagatcg ccgcggagct
     2941 cggtctgggc gaggtgctcc actggcacat cacctcacgc agcacgctcg ccgacgcgct
     3001 ctaccgctat gacgcgctcg gccgtatcca cgcccacaac ctgcgcatgc tcgacggcac
     3061 aacccggccc gccgggaacg accatgagga cgagatcggc gagttcgtcc agctcggtcc
     3121 cctgggaacc gcgctgctcc cgggcggccg tccccgggcc ctgctgatcg acgagatcga
     3181 caagagcgac ctcgacctgc ccagcgacct cctcgacgtc ctggagcgcg gcggcttcga
     3241 gatccccgaa ctggcccggc atcccgagcc ggagatcacg gtccgtaccg ccgacaagga
     3301 ccgcacgcac accgtcgagc gcggccgcat ccagtgcgac gagttcccgg tcatcgtgct
     3361 gaccagcaac ggtgaacgcg acttccccgc ccccttcctg cggcgctgcg tccgtttcga
     3421 catgcccccg ctctcccagg aggccctcac cgagatcgtc gccgcccacc tggacgagct
     3481 ggacgccgcc accaccgaca gcctggtgaa gaccttcctc gacagactga acgccggaga
     3541 gtccgtcgcc gtcgaccagc tcctcagcgc cgtctacctg ctgcgcggcg accggatccc
     3601 ggacgcgggc cagcgccgga gcatggagga gctgctgctg cgagggctcg gacgtggctg
     3661 agagcgccgc cgcccggctg gcgcggctcg ctctggcggg cgagggcgag ggcgagggcg
     3721 acggcgacat cgacgtcaag gaccttctcg acgccctgct cctcgcctcc gcgctggcgc
     3781 accgcgacgg gccgcccggc agccactcct ccgacgcccc ggacgacacc ccacagcccc
     3841 aggacggaga cgcggccggc acgtcgtctc ccgcgaaggg ccttccggta ccggcagacg
     3901 acgagacgga cgacgcctca cagcccgcgg cctcggtgtg gctggaggac caggaaggcg
     3961 ccctgagggt tccggggaag cggctgagcg tcggccgtgc cgccgccctt ccccgggccc
     4021 tcgacatcgg ccgtgcgctg cgcccgctgc gccgcccctg gctctccggc gtccgcggtc
     4081 gcctcgacgt cgacgccacc gtcgagtact acacccgtac cggcatgctc gtcccgcggc
     4141 tcgcgcccgc gccggagccc tggctggagg cgatcgtcgt cctcgaccgc ggcaccgcca
     4201 tggcggtgtg ggacgagacg gtccgcgcct tcaccgggac gctgcgcgcg ctggccgcct
     4261 tccgtcatgt acgcgtctgg catctcgagc atccgcccgg cggcacgccc gtgctgtacg
     4321 accatcacgg ccgggcgctc cccatggacc cggacgccgc ccgccacacc cagccggccc
     4381 ggcgcctcct gctcgtcgtc tccgactgcg cggctccggc atggcggcag gacgccctgt
     4441 ggcggaccct ccacgtctgg ggccgcaccg cacccgtcgc cctggtcaac ccgctgccca
     4501 aacggctctg gcagcgttcc ggcctcgacc ttccccggac cacggccacc gccgggatcc
     4561 ctgcctcccc cggccgcctc ctctcctacc gtcctccccg gctgctgcgg atgacggcgg
     4621 agacgaagcc ctggcaggca ctgccggtcc tgcagttcga ccccggccag gttctcgcct
     4681 ggacccgcac cctgatgcgc acggacccgt ccggctgcga ggccgtcctc gtccccgcca
     4741 ccggccggcc cccgctgcgt cccggccgtg ccgcacccgc cggccggccc ggcgcggcat
     4801 cgcccgagga ccaagtggcc gctcacgccg aggcgttcac cgacgaccgc cggtcgcccg
     4861 ctgtgcggct cgccctcgcg gcctccccgc tcggctcctt caccctgtcc gtcctcggcg
     4921 tgctccgtga gcgtctcgtc cccgaggccg acctcgccga catcgccgaa ttcctcaccg
     4981 cggggctgct caccgtcacc cgccaggatg cggccgatcc cctctaccgg tttcaccccg
     5041 cggcggcggc gcacctgacc ggtctgctca cccgcgacca gctctgggac acccatttcg
     5101 ccctcaccga ccacctcgac tcccatccgc aggccccgca cggcatcgtc accgttctgc
     5161 acgcgccgga gggcgaggag cacctgccgg ccggactccg gccgatcgct catgcggccg
     5221 cggccaccgc gaggctgctg ggggtcgagc cgaccgaacc gcttcccggc ggcgtgcgtc
     5281 cggccggtcc ggcgtccccc tcacctccgc acaccgacgt ggccgaggac gacgccccgg
     5341 ctccggagcc accggaactg gtgctcaccg gccaccgggg tgcggtccgg gacctgtcct
     5401 tcgctcccga cggcgcgcgt atcgccaccg cgggcgacga cggaacggtg cggatctggg
     5461 acctggccac cggcgcccga ctcgtcgaac tcgccggcca ggacggccgg atccggtgcg
     5521 tggcccactc gcccgacggc tcccgcatcg ccactgtggg tactcgcggc gtcgcgcggg
     5581 tccgggacct cacgacgctc cgggacacaa gcgtcctgat gggtgaggtg tcgtccatgg
     5641 cctggtcgcc ccgcggcgat cacctcgccg tcggcacagc cgacggcaca acgcatctcg
     5701 tcgcgggtga ggaactccgc tacctcgagc ccggtcacag cgagcgtgtc accgcggtgg
     5761 ccttctcacc ggacggtgcc catttcgcca ccgccttcat gggcaccacc gtgcacatct
     5821 gggaggtgtc cagcggttcc ctcgtcgtcg tgctgggaca cgagggatcc gtcaccagcg
     5881 tggcctactc gcccgacggc acccgcgtcg ccaccgggag cagtgacagc accgcccgta
     5941 tctgggacgc cgcgaccggc aggtgcgtcg ccgtactgac cggccactcg ggctccgtca
     6001 ggggggtggc gttctcgccg gacggcaccc acatcgcgac cgccggtcag gacggcaccg
     6061 tacgggtccg ggatgtcgtc tcgggcgccg aactggtcgg catcccccac gagtccccgg
     6121 tcaccgcggt ggcgtacgca ccggacggaa cgcttctcgc caccgcgggc gaggacggca
     6181 tcgcgcagct gtggcgcatg cggccgcccc cgcaccgcga cccgagccag aacctcgacc
     6241 ccgaggaggg gaccgcctcc ccgcccgagg gcggcggccg ggagacatcg gacatcgcga
     6301 gcagactcgc ccgtgcgaac gacctcaccg gtccggaact gcgggccgtg gtggaggagg
     6361 gcatcggctg ggcacgcacg cgcgtgcgcg aggccgggtg caccgctgtc ctgaaaccgc
     6421 ttctcgagtg caccgggctc acgaccgcgg aacgcgaggt gtccgtcgcg ctggccggtg
     6481 aatggctgga acaccatgtg ttcgccggat acgcgagcta cttgatccgc ccgttgctgg
     6541 agcgcccgga cctcaccgag ggccagctgc gcaaagcggt cgtcctcacc ggtgaatggc
     6601 tgagggccca cggccgggaa tacgcggccg acttcgtcat ccgcgcgctg ctggagcgcc
     6661 gggacctcac cgagggcgag ctgcgcggag cggtcgtctt cgccggtgac tggctgaagg
     6721 agcacggccg gagacatgcg gccgacttcc tggtccgcgc gctgctctcg cgtgacgacc
     6781 tcacagccgc ggagaaccgc acggcggtgg acttcgccgc cgtctggctg cgcaggcggc
     6841 agcgggcccc cgagagcagt ttcgtcctcg ccagcctcct gagcagagcg gatctcgcct
     6901 cggccctggt ccgggagacc gtctcgaccg ccctcgaatg gctcggcacc cacggacaga
     6961 ccccagcagc ctgcttcgtc ctccgggccc tcctcgaccg caccgacctg acgtccgacg
     7021 acgccgtacg agcggcctcg tccgccctcg gctggctgga ggtccacccg tcgggccgga
     7081 acgccagctt cgtgctgact cccctgctgg cccgtgcgga gctgcgcgga gaacaggcgg
     7141 accacgcctt gtcggcggcc atgaactggc tggaaggggc cggagggacc aacgaggcga
     7201 acttcgtcct gcgtcagctg ctcaggcgcc gggacctcac cgacggcctg acccgggaag
     7261 ccgtcgccag atccctcacc tggctgcgcc tgcacggtca caccgtgcag gcgggttttg
     7321 tgatcggccc cctgctcctc cgccaggatc tcaccccgga cgaggccgag caggcgacgg
     7381 cgctcgccct ccactgggcg cgacggcacc ggggcgcgcc ggaagccgag ttccccctcc
     7441 gctccctgct gcagcgcagt gatctcagcg aggccgccgc ggagaccctg acctccctcg
     7501 ccgccgactg gctggacgcc caccgcgaca gccctagggc gagtcatgtc ctcaccgccc
     7561 tgctcggccg caccgacctc gacgacgagc agagcggccg gatccgggag gccgccaccg
     7621 actggctgcg caccaacggc gatctgtccg aggccgcccg cgtcctcaac gcgcgactcg
     7681 gccggtcagg agggactgac gaacaggcgc gcgagccggt cgccgacgcc ctgtcctatg
     7741 tgcgccggca catcggcgag acggcgaacc ttcagctcct ggaaacgctg atgaagagcg
     7801 ggaaactcgc cgcggaggac acccgggaca tcgtgtcgat caccctcgac tgggtggacg
     7861 cacacgtcgg cgagcgggag gtcgctcatc atctccgcct gctgctcgcc gccggggacg
     7921 tcacagacca ggccctcgac cggactgtcg ccctcaccgc tcgctggctc gagcacaacg
     7981 tcacctcgcc cggagcctgg tccgtcctcg acggactgct cgcgcgcgag gaggtcaccg
     8041 gggaccggct gcgcgcggcg gtggccttcg ccgggttgtg gatgagggat cacgcgtcga
     8101 cgatggaagc ccagttcatc ctcagcaggc tgctgctccg ggccgacctc actcccggcg
     8161 agcagcgcga cgccgtcgcc gcctccttcg catggctgcg gctgcacggc acgacctggg
     8221 gggcgcagtt cattctcccc ccgctcagtg cgcacccgtc cctcaccccg gaccaggtgg
     8281 accaggcctt cgagtgctcc cgggactggt tgctccgcca cccggcccag cacagcaccc
     8341 aggacgtcat ggaagccgtc ctcctccggt ccggcctgac cgctgcccag gtgcggacgg
     8401 tggcgtccgc cgtcctgcga tggagcaccg accacgcgga cgagaccaac tcccggcgca
     8461 tgctgaagac cctgctgtcc cgggccgacc tccccgagga catcctcacc gaggccgtcg
     8521 gcctcgcgta cgacggcctc agcgccgatc cgacggccct ggacgccggc tacctcctgg
     8581 acgccctgct ccgcgtgcag gacctgccgg cggaccagct cacccccacc ctcacctggg
     8641 ccttccagtg gctgcacgag cacatgccgg cctggcggtc acgcatggtc ctgcgagcgc
     8701 tcctcggccg gaactccctg acaccggagc aggcacggct cgtcatgcgc agcgcggtgg
     8761 tctggctgcg ggagcacgcg gcggcctctg cctccggcgg ctcgaggagg gctgcgcggg
     8821 agatgctcga gttgctcctc gcccgggagg acatcaccga ggacatcgcg cgacaggccg
     8881 gggaattcgc gtatctgcgc cgctgagaaa cgcaccgagg aaggggacgg ggagcggcgt
     8941 gcggggcccg gcccgcccag cggaccgggc cccgggccgg cctgtcagac gcggtcggcc
     9001 acgatcagca ggtactggaa gctgccgttc gcgtacgcgg tcaggaacgc gtcctcgatg
     9061 cccgtgacca ggtggtcggc ctccttgcgc agctcccagt acgggacggt ggccgacgtc
     9121 aggtcctgta cgtggacggg cacgagccgg ttgcgggcca gggcgcggaa gtactccgac
     9181 cgcgggtgga tgtcacagat gtagtgggcg ttgatgaggg acacctcgcg ggacgcccgc
     9241 ccgtacgtgt cgtcgtagca gccggtgatg gtgacgtagc gcccgccgcg gcgcagcagc
     9301 cgggcgtgct ccgcgaacag caggtccagc tccacgtaca tcgtggactc gttgttccag
     9361 gacgcggcgt aggcgccgga ggcgaacccg gtgtcgagca tgtcgcggtg gtggtagcgc
     9421 accttgtcgg cgatgtcccg ccgcctggcc tgctcgttgg cgaagtcggc ctgcttgccg
     9481 gagatcgtga ccccgtcggc ctcgcagccg taccgcagat gggcgaccac gctgccgccg
     9541 ccgcgcccgc acccggcgtc gaagacccgg tcggcggggg agagggggcc gaggtgggag
     9601 gcgagcagct cggcctgggc ctgctccaga cggtgcagct cggcggtgat ccgctcccgg
     9661 cgccggacga ggccggtctc gtccagcacg gaccagtcga cgttcccgac gccgtagtgg
     9721 tggtggtaga ggtcgtcgat ccttccgagc tcgaggttga ccgggttctc ctcggcgttc
     9781 cagtaggccg cgacgcggtt ctggtacgtg gactggggcg gcaccggtgc cgtcgtggcg
     9841 ctcttgacgt tcttactgtt cgtggcgctg ggcgtgctgg cgttgcttgt catgcttgcc
     9901 gttcctgcgg tgctcgtggt gctcacggtg ccgatgtcgg tcgtggtcaa cggtgactct
     9961 cctcgtggta cgggtgtggg ggacggagac aggcgggaac tcaccagtag ttcggcaggt
    10021 ggtagcggtg ggtgttggtg gcgtgccact cgtggttgcc ggagacccag gcggcgagac
    10081 cggcggcata gcgccccacc agcggtgacc cggcggacag gaccgcggac tccgcctcga
    10141 acgccgccat gatccggttg tggatctcga cggcctccag atacgcggcc ttcagcccgc
    10201 accgctcgtt ggcggcgatg acccgcggca ggttgagatg ggcagggtcg gccagttcct
    10261 tggtgaagga gtacaggtcg ttgacgatcg tggtggcgtt gcaggccagg gcggtgatcc
    10321 gctgggtctc cgggcgggcg tacaggggct ccggcagctc gtaaccgtcc acggcgtcga
    10381 cgatcgacag acaggggcgg aagttgttga actgccgcat caccaggtac tcccacacgc
    10441 gcggcacgta ccggacctcg gcccaggcag cctccgcgag gtagcccaga tgcagccgcg
    10501 cgatgtcgtg cacgaaccgg ccggtctggc tgggcgtcgc gaaggcggcg tagtccttca
    10561 gcgcccagtg gtaggagcgc agcgggccgt cggcccgcac accgcgccgc cactcctcct
    10621 ccagctcggg aacgccgtgg tacgggtcga tcgccgactg ggccatcacc agccggcccc
    10681 cgagcccgcg cggcgatccg cccctgccct cctccgcctc gcaatagcag ctgtcgacga
    10741 cgttctcggc cagcaacagc ttgccggccg tcgtgaggcg gtccaggtcg gccgcgcccg
    10801 gatgctggag cgcgacggcc cggccgaact ggaacccggt gaagtcgccc gtccacgcct
    10861 cggggaacag ttccagctcc ctcgcccagg catccagcct gcggtccacc tcggcggcct
    10921 tctccggatc ggcgggcacg gcgggccggt acagcagtcc gggaatcgcc ccgctccgcc
    10981 gggcgggcgt gatacgcggt ggccgcggcg gcccgggcaa ccgccaggcc cgcggcgcgc
    11041 ccggctccgg cggcgtgccg gagaccggag tcgcatccga tgtcagtgcc gtgccggaga
    11101 ccggagtcgc atccgatgtc agtgccgtgc cggagaccgg ggatgtgccg gagcccagtg
    11161 gcgcgcccga gtccggtggg gggccggtct ccggcgacgt accgggctcc ggcgccctgc
    11221 cggatccggg cgatggggcc ggatcacacg gtgcgtcgca cggctcatgc ggtgtatggg
    11281 gctcgtgcgg cggtgtaccg gggccctgct gtgcgctcca cccgagtgac gtgtgggacc
    11341 cctgcgggac accggacgcg ccggctgccg acggaacgct cattccggca tccacccgac
    11401 ctggacgttc tccaggacac ccgcggcgtc gggcaccagg atggccatcg agtagtaggc
    11461 ggtcacgagg tagctcatga tcgcggcctt gtcgatgccc atgaaccgta cgttgagacc
    11521 gggttcgtac tcctcgggga tgccggtctg gtggaggccg acgactccct ggtccttctc
    11581 accggtgcgg agcgcgatga tgctgctcgt gtgctgcgga ctgatcggga tcttgccgca
    11641 ggggaacacc gggacgccgc gccacgcggg tacctcgtgt ccgtcgacgt tcacggtgcc
    11701 gggcaccagt ccgcgccggt tgcactgccg gaagaaggcc gcgatgacct tcggatgggc
    11761 caggaacagc cgggtcttgc ggcgcatcgt cagcagttcg tcgaggtcgt ccggcgtggg
    11821 cgggccggag aaggtgctga tgcgctgccc gtggtcgatg ttgtgcagca gcccgaactc
    11881 ccggttgttg accagctccc actcctggcg ttcgcggatc tcctcgacgg tcaggcggag
    11941 ttgctgctcc gtctggttca tcgggtcgtt gaagaggtcg gtgacccggg tgtggacgcg
    12001 caggaccgtc tgcgtcaggg agagctcgta ctcgcgtggt gccaggtcgt agtcgacgaa
    12061 gccgccggag atgacgggct cgcccacgtg cccggcctgc acggggacat cggcctcgcc
    12121 cttgcggttc atgggtttgc tctgccgttc cgcgaaggcg tccagatggg cggcgaggga
    12181 cggggcgcgc tccacgaagt cctcgaggac gtcccaggga agggccatca ccgttcccgg
    12241 ggtctccgcc cgtaccgagc cgagccagag cggatcggcg cggccgacgg cctcgtcccc
    12301 cagcccttcg ccgtccgtga cgaccccggt gacctcctcc tcgccgtact tgccggtcgc
    12361 gaagcgggtg aaccggccgt ggacgatcag atacgcctcg gtgacgggct gcccggcctc
    12421 gaagaggacc tggccggccc ggacggtgcg gagccggaac cgcgaggcca gctcgttcag
    12481 cacgtccatg tcggagtagc cgcgcagggc cggcagttcg gtgagcgtcc gggggatgac
    12541 cttgatgtgg tcggcgccgt tctgctcgaa ctgcacccgg ccccggccga tgcggagctg
    12601 gagacggcgg ttcacccggt aggtgccgcc cttgacgtcc acccagggca gcgtcttgag
    12661 cagccaccgc gaggtgatgg cctgcatctg cggttcggac ttggtggtcg tggcgagccg
    12721 gcgtgctgcc tcggtgccga ggctggtgaa ctgctgtgcg tcggcatcgg gtccggtggg
    12781 cccggtggtg ctgtcggggg tgttctccgg cgagctgtcc gggacggtca ctgtccctcc
    12841 cttgcgagag cgggcgaagg cggaaacggg cgaaaggggc gggcggccca ggaggggccg
    12901 gtggggggcg ggtggggacg tcacgtcaca aggcgccata tctgtcccgt gggcgtgtcg
    12961 cgtcatgggt gtgggtgacc gggaccgcgg gtgtggacat gggcgtgggc gaaccgacgg
    13021 tgacgggtgt ccgcgaacgg cttccggaga gacgggcgac gggcgccatg acggcgagct
    13081 ggtgacggga tcctgtggcg gtgcgtgcga ccgggccgga cgcggcgcag gacaagccaa
    13141 acagtccggg tgacggccgg gaacagcgtg aaaggggcgc cttcacgacc ccgggggtac
    13201 ggatcggccg catggggtga gcagcccgga gccgtacgct cccgcgccgg tcatccgttt
    13261 cctggccacc ggcgcgggag gcgcacgcag ccgctcgccc ggcctccggt caccggcgcg
    13321 tgaggcgcac aacacgcctg ccgcggcggc ggccggcagg gcgttcgcgc ggtcgcggcg
    13381 gtggagggct tcctacggtc gcggcggtgg agggctttca cggtcgcggc ggcagggtgt
    13441 ggtccatggc tgtggcggca gcggcagggc gttcccggtc ccgctgtcgc gcgtgtggtt
    13501 gcgcggttca ggtgaagcgg cgagccgagc gtacgagcca gtcgaaggcg ccgcgcgccg
    13561 tgaacgcgct ctggccgccg cgcaccagca gccccgcggc ggccgcggtg gcgaacgccg
    13621 gggcgtcggc ctgcgcggcg agatacggga ccgcgacgca gcgcataccg gcggcatggg
    13681 cggcggccac gcccggggcc gcgtcctcca cgaccacgca gtcggcggga gcggcgccca
    13741 gccgccgcgc ggcctccagg aacacgtcgg gcgccggctt gccgcgcggg acctcgtcgg
    13801 cggagacgac cgtcttcaga cggtcggcga gccctgtgcc ggcgaggatc gcctcgatcg
    13861 cttcccgtga ggaacccgag gccacggcca tcggcacccc ctccttcgcc agcaggtgca
    13921 cgaacgcccg catctcgggg tacacgcgcg tggaggcccg cgccagctcc agatagcggc
    13981 ggttcttgtc ggcgagcagc tcctcggccg gggcctccag gccgtaccgc tcctgccaga
    14041 gggcgatcgt ctcctgtgtg ctgatgccga tgtaccgctc gtggtccgcc caggtgaagt
    14101 ccgtgacgcc ctgctcggcg agggtctgcc ggcccgcctc gaagtagttg ggctcgctgt
    14161 ccacgagcgt gccgtcgaga tcgaacacga ccgagatgct gccgaggatg cccatgggac
    14221 cagaatgcca agcgcggtcc ggcccccggc ggtcaccccc cggcggcccg gcccaccgcc
    14281 tccaccagcg gcagcagccg gtgcggtacg cgttcgcgca gcgccacctc ggtacgggtg
    14341 cggaccacgc cgggcaggct gatcagtgac tggatcacgt cctccagatg ggcgttgtcg
    14401 cgcgccacca cccgggtcag cagatcgccg ccgcccgtga tcgagaacgc ctcgacgatc
    14461 tccgggacgg cggccagcgc ctcgcccacg tcgtcgagat ggccctgggt gacctcgatg
    14521 tgcacgaagg cgaggaccgg gtggcccagt gcggcggggg acagtgaggg tcccgtgccg
    14581 gtgatcacgc cctcccgttc cagccggtcc agacgggcct gcagcgtgcc gcgcgcgacg
    14641 ccgaggatcc gggcgtactc gcgcgcgctg gtgcgcggct gctccaggag cagccgcagg
    14701 atgcgggtgt cgagctcgtc cacggccatg gtccgttggc cttcctgccg tcgcggatga
    14761 tcgtcggtga ctgtaccaat ggaccagtgg aacagcagcc tgttgagcca ctgccgtacg
    14821 gatgctttcc taatcactat caatggcgcc gcgcagcgca ggacggcaat gaagccggat
    14881 ccgtgcccgc ggcgccattc ccatgtcatg aggttcatgc catgaggccc atgtcatgag
    14941 gtccttccgt ccccatgtca tgcggcctgt cgtggcccag ggccgccgga agagggaagg
    15001 ggcgtgctgc cgacggtgaa gaggatgttc atggctccgg atccgggcct gctgcggctg
    15061 agggtgtcgc tgcgcgcggt gctcggcatc ggtctcgcgg tggccgcgtc ggaactggcc
    15121 gggctgtcgc tgaccgcctc cgtcacggcc ggtctcgcgg ccctgctcgc gctgttcacg
    15181 gtcgccgacg cgaccgtgcg cggccaggcg gtcaccacgg cgctgctgcc ggtcgccggc
    15241 ttcccggtgc tggcgctcgc gaccgccctg cacgggacgc ccgcgctgcg ggacgcctgc
    15301 tggctcgccg tcgtcttctg cggcgtctac gcccgccgct gggggccgcg cggcaacgcg
    15361 ctcggcatct tcgcgttcat gaccttcttc gtcacccagt tcctgcacgc ggtgcccggc
    15421 cagctgccgg agctgtacgg cgccatagcg ctggccctgg ccgcggcctc cggcgtgcgc
    15481 ttcggcgcct ggtgcatcga acggcgcacc ccgccggccg ccgtgctccc tccgctcgac
    15541 ggtcgcgggg cggcccggcc caccacgcgg caggccttcc aggccacggt cgcctgcgcc
    15601 ttcgcgatga ccgccgggca ggtcctctcc cacgagcgct ggtactgggc ggtcggcacc
    15661 gcctggtgga tcttcgtcaa cacggcgtcg cggggcgaga cactcgtacg cggcttccgg
    15721 cgcgtcgtgg ggacggtcac cgggatcgcc gccggactgc tcgtcgccgt acccctggac
    15781 ggtgccccgg cgcccaccgc cgtgctcgtc gccgtctgtg tgttcggcat cttctacacg
    15841 gctccgctct cctacagctg gatgatgttc ttcgtcacgg tcatggccgg tctgctgtac
    15901 gggctgctcg gcgtgctgca cccggggctg ctggccctgc ggttcacgga gaccgccgcc
    15961 ggggcggccg gagcggcgct cgccgtggcg ctcgtcctgc ccgtcaccac ccacgccgtc
    16021 accgaccgct gggtgcggcg ggccctgcac gcggtgcacg ggtgcaccgc tgtggcggcc
    16081 cggcgcctgg ccggggacgc cgccgccgac ccggcgccgc gcgcggcgga gctggaggcg
    16141 ctgctggggc gcgtacggct gtcggtcgcc cctctcgtgc atccgctcaa cccgctgcgg
    16201 gagcgcaagc ggcgggcccg ccaggtgctc gccctgctgg acgactgcgc ccgggagacg
    16261 cgcgggctcg tggctgtcgc cgccgatccg gacgcctcgc acgacgcccg cctcacggcc
    16321 gcgtgcctgc gtgtggagac ggcggtcgag gcgctggtcg gagccgtgcc ggagcgcgcc
    16381 gtaccggcac acgcgggcgc gccggggcac cacccgggtg cggagcaggc cctcgcgcac
    16441 ctgcacgccc tggagcgagc cctgaccgcc ctcgccgcac ccctgcgcca gtcaccgctg
    16501 gctggagcct gactcacgcg acacgctgat gtgacagtcc gacgtgaccg ggtgagcgac
    16561 acgccccggt ggcggagacc cggcgaaccg gttctcttgg tctagacctg ctgctaccgt
    16621 ctgccccgag cggtcagcgc agcgcccggc cggcggtggc ggtgcgacgc cgatgggccc
    16681 gcgacagcgg aaggggacgg cggtggcgga ggaagacgcc cacgggcggg caggacgggc
    16741 gtacatcggg tcgttcacga cggcgggcgg tcccggcatc gtcgtggcgg cggtggacgg
    16801 ggagagcggc acgctcaccc cgctgggcgg cgtggacggc gtggacggcg ttccgaaccc
    16861 gtcgtacctc gccctgtcgc ccggtggcga cctgctctac gccgtcagcg agacggccga
    16921 gggcgccgtg gccgcctacc gcctgaccgg cgacagcctc gaaccggcag ggccgccggt
    16981 gcccgtgccc gtacccggca gcgggcccac gcacctcggt ctgttcgccg gccacgtcct
    17041 gaccgccgac tacggctccg gcagcatcac cgccgtgccg ctgcgcaccg acggcaccct
    17101 cgcggaaacg gcctccggag tgctccggca caccggttcc ggcccgcacc cggaacggca
    17161 gcgggggccg cacgcccacc aggtgcaggc cgaccccggt ggccactggg ccgtcggcgt
    17221 cgacctcggc acggactccg tgctcgtgtg cgcgctggac gccggacggc ccgtcctgca
    17281 cggcgagacc gcgctccggc ccggctcggg accacgccac ctggccttcc acccggacgg
    17341 ccggcacgcc tacgtggtgc acgagctcga gcccatcgtc accgtgtgcc ggtgggacac
    17401 ggtgacgggc ctgccgatcc ctctcggcga ggttgcgctg ctgccggaca ccccggacgg
    17461 cgacgcgtac ccgtcgggga tcgccgtctc gcccgatggc cgcttcgtat ggacggcgac
    17521 ccgcggccag gacgtgctgt ccgtgctcgc ggtggacggg gacggcgaga ctctgcggcc
    17581 ggtggagacg gtgccctgcg gcggccactg gccgcgcgcg ctcaccgtct ccggctgcgg
    17641 acggttcctg tacgtcgcca acgagcgctc cggggacgtc acatggttcg cggtcgaccc
    17701 ggacacgggc gtaccccggc ggagcggatc cgtcgcggtg cccgccgcgt cctgcgtggt
    17761 gctcggctga cgcacgcgcc ccggtcgtag caccggcgca cagcgtgagg gcccgctccc
    17821 gtctcggggc gggccctcac ggccaaccgg cgcgtacgaa cgcgggggcg ccgttcggct
    17881 cggttccgct cagcggaccg gcatgccctg cggctgctgc ggggcgatgc ccagcgccgt
    17941 catgtacttg gagagcacca gcttaccgac cgccgggtac gcgccgagcg cctccgcggt
    18001 ggcgcagtcc acctccttgg cggccgcgtc cagcagtccg gcgtcgatct ccgggccgat
    18061 caggtacggg gcgagcgcga gctgctggga gccggaggaa cgcagctgct ccgcgacgga
    18121 cgcgatcgaa ccgtcctcgt cgagcgccgc ggccatcacc ggcacggcga gccgcgccgc
    18181 gagcagcatg cccgtgatgc ccgccgcctg cacggcctcg tcgccgccca cggacgccag
    18241 gatgatgccg tccgccgcgg tcgccacggt gaacagccgg gcacggtcgg cacgtgccag
    18301 tcccgcctcg gacaggcgca cgtgcagcgc ctccgcgagc agcgggtgcg ggccgaggac
    18361 atcggtcagc tcggcggcga cacggctctc catcacggcc tggcggacct ggcgcagcag
    18421 cgagccgtcc gggccggcca gcagcggcac gaccacgccc acggggccgt ccggttcctt
    18481 cacgtccatg ccggcggcgc gggcctgctc gtagcgggcc gtgcgctcct cgccgacacg
    18541 cgcgagcacg gactgcaagg tcgggaactc gtcaccgttc ccgtcgaggt acccgatccg
    18601 cgcgtccagg ccgggcagct cggagcgcgc gatgctcacg acctcctcgg cgaggctgcg
    18661 tgtggcggcg ctgggcgtgc ccggcaccgc gagaacgagc gcgggcgcgc cttcgggagc
    18721 caccaggggt tccggacggc ggtgccgccc gggctggcgg ggtcgcggca ttcgtacagg
    18781 caggccggat gcgggcccag tgggggagct catggcgccg catgctactg gctttgtggg
    18841 ttcccctgtt cggggagggt gcaggtgagc ggtatccgtc cgcatttgtc tgatgagtta
    18901 cttgccgatc agcggagata gcgtgcgttc cggctctgcg gggagcggct tcgccgatcg
    18961 cccgcggcgg tccgcggata cgggaggacg cgcgttcggc acggagaagt gcctgtccgg
    19021 tacgaggtgt tggtccgctt tgcggggtca gtttccggcc acctcgtgga gcatccgcgc
    19081 gtcgcgtggc agcgcgaggg ccccggtggc cagttcggtg gcgatgcgta cggcaccgtg
    19141 cagcggatcg ccctcggcgg gtacgcgccg cgcgtgcggg agccgctcct tcagctccag
    19201 ttccagcggc gcgaggaggg gctcgcccat gtggaacacg cctcccgtga gggcgatcag
    19261 aggctcgccg tcggccgggc agaccgccgc ggcggagtcg gccatgtgcc gggccgccgc
    19321 gcgcaggatg tccgccgcca ccgggtcgtg cccggcgcag gcggcgacct gcggggcgaa
    19381 ggaggcgagc acggcggggc ggtccgtgcg cgggtagagg cgcgccggca gctcgctcac
    19441 cggaccgaac atctcctcgg cgcgcaccag cagaagggcc gagccctcgg ggcgtccgtc
    19501 gtgggcgcgc agtgccgcct ccaggcccgc ccggccgatc cacgcaccgc cgccgcagtc
    19561 gcccagcaga tgaccccagc cgtccgccct gcgccagcgc tccaggtcgg tgccgatcgc
    19621 gatcagtccg gtgccggcgg cgaccaccgc accggcgtgt gggccgaggg cgccggtgta
    19681 cgcggtgacc gcatcggcga ccagggcgat cctgggcgcg ccgaactcac gcgtcagggc
    19741 ggggggcagt tcggcgcgca tccggtcacc gagggtggcg aaaccggtgg cgccgacgac
    19801 gaccgcgcgc ggggggccgg ccccggcggc gccgatcaac tgccgcgcca tgggtagcag
    19861 ttgctccagc agatgcccgg cgtcgacacc gcgtgccccg atccgcacgg gctcgccgga
    19921 caccaaggga tcagcaagaa cctcaccgcc cgccgccagt acgacacgca gcccggagcc
    19981 cccggagtcg acggccagca cgagcggcga gcccggacca tcggagccgg agccggagcc
    20041 ggagccggag ccggagcggg gtttgttgtt ggagctggag ctggagctgg agtcggtgcg
    20101 ggtgcgggtg cgggtgcggg tgcgggtgcc gatgtcggag ccggtgacgg cgggcggttc
    20161 cggaccatcg gagtcggcag ccggagcggt cgggggaacc ggagcgtgcg gcgacggtgc
    20221 gggccgcggc ggttgcccgg cccggcggcg gctcgttccc ggcgcgccgt cagagggtga
    20281 cggcgcgccg gacaccagca ccggcgtcgg cttcggtgcc ggcctcggcc tcggctccgg
    20341 ccccgtgccg gtcatggcag gcgccagtcc accggctggg ctccctgccg caggagcagg
    20401 tcgttggccc ggctgaacgg ccgggagccg aagaaaccgc ggtccgcgga catgggagag
    20461 ggatgggcgg attcgatcga cgggtagtcg ccgagcaggg gacggaggtt acgggcgtca
    20521 cggccccaga ggatggacac cagtggacgg ccgcgcgcca ccaatgccct gatcgcctgc
    20581 tccgtgacct cctcccagcc cttgccgcgg tgcgccgccg gccgccgcgg agccgtggtg
    20641 agcgccctgt tgagcaacag cacaccctgc tgggtccacg gcgtcaggtc cccgttggac
    20701 ggctggggca gctccagatc ggcctgcagc tcccggtaga tgttgatgag gctgcccggc
    20761 agcggccgca cgtccggtgc gaccgagaac gagagcccca ccgcgtgtcc cggtgtcggg
    20821 tacggatcct gtccgacgat caggacgcgg acgtcgtcga agggctgctg gaaggcccgc
    20881 aggacgttcg gcccggccgg gagataggtg cgtcccgcgg cgagctccgc gcgcaggaag
    20941 tcacccatct cggcgatccg tccggtcacg ggttccagag ccttcgccca gcccgcctcg
    21001 acgatttcat gcaacggtcg tggtgccacg gcgtcaccct actgccgtcc gcgcggacgc
    21061 gatcaaccag tggccgcggc acgacc
//
