LOCUS       NZ_BMVW01000017        24560 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence17, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000017
VERSION     NZ_BMVW01000017.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 212793)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 69893
            Orig. end                         :: 94453
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24560
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24560
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24560
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14560]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14560
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            115..1443
                     /locus_tag="IE242_RS30865"
                     /old_locus_tag="GCM10010365_63250"
     CDS             115..1443
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976940.1"
                     /locus_tag="IE242_RS30865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63250"
                     /product="polysaccharide lyase family 1 protein"
                     /protein_id="WP_189865167.1"
                     /transl_table=11
                     /translation="MRTRTWHGPATRTTALAGCTALVLAVTATAASATGHGHSRDHARQ
                     TLAAGDGWAAEGTGTTGGAAASAEHVYTVTTWDGFKAALADGGDAPKIVKVKGVIDPVA
                     EGCASFEAEGYDFDAYLEKYSPENWGLDEDLSGEPADSPEGLRAASAAAQDKAIKVNIP
                     ANTTIVGVGRDAGIRGGSLQIRGVDNVIVRNLTIEAPLDCFPQWDPTDGDNGAWNSEYD
                     AVVVYGSTHVWIDHNTLTDGRYPDSTLPTYFGQTYQQHDGLLDVVRGANYVTASWNSFE
                     NHDKTILIGNSDSAGATDTGKLKVTLHHNRFKGIVERAPRVRFGQVDAYNNHFVVTKDQ
                     KYGYSFGVGASSQLYAEKNAFSLPSGISAAKTLKKWSEAPLTAKNNYVNGKRTDLIAVH
                     NAEIPGETLQSDAGWTPTLRKRVDSPLAVPLIVALGAGAGKVR"
     gene            1458..2576
                     /locus_tag="IE242_RS30870"
                     /old_locus_tag="GCM10010365_63260"
     CDS             1458..2576
                     /GO_function="GO:0030599 - pectinesterase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042545 - cell wall modification [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329294.1"
                     /locus_tag="IE242_RS30870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63260"
                     /product="pectinesterase family protein"
                     /protein_id="WP_189865405.1"
                     /transl_table=11
                     /translation="MERPSLSRRSFVGASAGAGAALALALASPARAHGRRSPFGRYGSP
                     RARLNGQTLYVHPGGLGDHTTVQAAVDAAGSGCTLVIAPGTYRETVAVSTARTEMTWLG
                     ASDDARDVTIVYDNAAGTPKPDGSGTYGTSGSATTTVQADGFTARHITFANDWLRADHP
                     GFSGTQAVAIKVQGDRSAFHHCRFLGHQDTLYADTRALGTFARQYYAHCYVEGDVDFVF
                     GRATAVYEHCHFRTLIRTDLTSAPYGFVFAPSTAGANPRGYLVTHSRVTSEAPDGYYKL
                     ARPWVPSSDTTARPMLTVRETRLGAGIDAVAPYTNMSSGYPWQDQRFAEYRNTGPGAAV
                     TVPENRPQLTRAEARSHTREAYLGDWTPWKVR"
     gene            2578..3636
                     /locus_tag="IE242_RS30875"
                     /old_locus_tag="GCM10010365_63270"
     CDS             2578..3636
                     /GO_function="GO:0030599 - pectinesterase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042545 - cell wall modification [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010355540.1"
                     /locus_tag="IE242_RS30875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63270"
                     /product="pectinesterase family protein"
                     /protein_id="WP_189865169.1"
                     /transl_table=11
                     /translation="MRRRTLLTGIAGGLTAVGVTPAPALAAPRRRRVLHVRPGGRGDHT
                     TVQAAVDAAEGPGWTVVVHPGTYREVVTVPADRPGLTLRGATGDPRDVVIVYDNANGTP
                     KPDGSGTYGTAGSATFTSAAPGLTVRDLTLANDWLRADHPEITGTQAVAAYLTGDRTHF
                     DNVWLLAHQDTLFVDTTALDVFDRQYFHRCHIEGDVDFVFGRATAVFEHCRFHTVRRDV
                     DFTPKGMVFAPSTARANPHGILAVHCRVTSAAEDGAYKLARPWVPSYETTAWPSLVVRD
                     TRIGPGIDAEAPYTNMREAYPWQTMRFAEYRNTGPGAAVTVPENRPQLTRAEARSHTRE
                     TYLGDWRPYAYA"
     gene            3623..4915
                     /locus_tag="IE242_RS30880"
                     /old_locus_tag="GCM10010365_63280"
     CDS             3623..4915
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037877.1"
                     /locus_tag="IE242_RS30880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63280"
                     /product="polysaccharide lyase family 1 protein"
                     /protein_id="WP_229859658.1"
                     /transl_table=11
                     /translation="MRMPKTLATALLACACLLLPQAAPASADGRPSTPEGWASAGSGTT
                     GGAGGTTWTVRTRAELKEALANDGNPTAPKVIRVVGAVDGHEADDGTLLGEQDYAPGYD
                     LTKYMSCFGEDGSTWSDTRYDYCKQQRQLRQTGSNREKAQIQLTVPSNTTLVGAGDDAR
                     LLGVFLTVNTGTDIIVRNLRLEAPVDHFTSWSPDDGSAGDWNARFDAMTVITGKNIWID
                     HCTFTDGRFPDREAPLGFHGEHVQRHDGLLDIEDGSDFITVSDSRFTDHDKAILIGSGD
                     GRGDRDRGHLKVTFVRNLFTGIAQRAPRVRFGQVHVVNNVHRGRADGTLYALGAGVESA
                     IFSERNVFTYPRGTSALAVADYGGERFHDTGSWFNGRPARLDAVASGLGLTGDVGWDPA
                     DVYDYRVLRSAKAVERYVLRHAGTGRPYAHP"
     gene            4902..6089
                     /locus_tag="IE242_RS30885"
                     /old_locus_tag="GCM10010365_63290"
     CDS             4902..6089
                     /EC_number="3.1.-.-"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121411.1"
                     /locus_tag="IE242_RS30885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63290"
                     /product="dienelactone hydrolase family protein"
                     /protein_id="WP_189865172.1"
                     /transl_table=11
                     /translation="MHIPEPLRHPLGRRTFVTGAATAMLLAGAGVGAGAGPARAEDLVG
                     GNLPDFHPALKDELRFPLAWGTSPHRDFRAWRRAARAKVEEHLLVDRQDRTPYDPEFTD
                     GPGGDGYRRQSVTVSLTRYERVRGSLLTPHGRGPFPAVLLLHDHGARFDIGKEKLVRPW
                     DDDTRLASARAWADKYFSGRFVGDELARRGFVVLSLDALGWGDRGPVTYEQQQALASNF
                     YNLGSSLAGLMAREDARAAGFLAGLDRVDARRVAAVGFSMGAYRAWQAAALSDDIAAAA
                     SVCWMTGLKEMMVPGNNTLRGQSSYYMLHPGLARHLDFPDVASIAAPRPMLFFHGAQDT
                     LFPAEGVEAAYEKMRAVWRSRHAGERLHTKVWPELGHVFTAPMQDEVFTWLDAVL"
     gene            complement(6157..8376)
                     /locus_tag="IE242_RS30890"
                     /old_locus_tag="GCM10010365_63300"
     CDS             complement(6157..8376)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009330864.1"
                     /locus_tag="IE242_RS30890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63300"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_189865174.1"
                     /transl_table=11
                     /translation="MRRTAHTLLLPLLALVPLLVSLLGAPSGWAHAEGHPVKKPQYAGY
                     LFAYFTGEGTADGEQIRYALSRGNDALHWRELNAGKPVLTSTIGEKGLRDPFVIRSPEG
                     DRFYMIATDLRMYRSSSGSWDDVQRHGSKSIMIWESTDLVNWTDQRLVRVSPDNAGNTW
                     APEAYWDDTLDAYVVFWASKLYADDDPDHTGSSYNRMMYATTKDFRTFSEPQIWSDPGY
                     SVIDSTVVEHEGTYYRYTKDERNPSSSSPCSKFITGEKSTSLTDTSYDFVADCIGNGDL
                     SRGEGPTVFKSNTEEKWYLFIDEYGGRGYVPFETTDLDSGEWTMSEDYQLPASPRHGTV
                     IPVTQEEYDRLLAAYPVSPTSVVDATARGQKGYAVVTEESSKVVLPMEPDADLRRLAPK
                     LWVGEGATVSPRSGTRRDFRKPQTYTVTAADGTRRTWTVEAVPTRSPVLPGLYADPDVR
                     YMDGRYWIYPTTDGFAGWGGTQFKAFSSKDLVHWKDHGVILDLGPDVSWADKNAWAPAI
                     AERDGKYYFYFCAEQQIGVAVADSPAGPFKDALGKPLIGKTDFPGGQMIDPAVFTDDDG
                     KSYLYWGNGRGYVVPLNDDMVSFDAAQVKDITPDNFREGSFVVKRKGTYYFMWSEDDTR
                     SENYHVAYATGPSPLGPWTKRGTILSKRPEYGIKATGHHSVVNVPGTDDWYMVYHRFAL
                     NGPGKAGGDGTHRETTIDRMRFAADGTIVPVVPTLESIKAVGRAD"
     misc_feature    8472..8487
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.03"
                     /tool="antismash"
     misc_feature    complement(8500..8516)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     misc_feature    complement(8513..8524)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     gene            8612..9763
                     /locus_tag="IE242_RS30895"
                     /old_locus_tag="GCM10010365_63310"
     CDS             8612..9763
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067483.1"
                     /locus_tag="IE242_RS30895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63310"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_189865176.1"
                     /transl_table=11
                     /translation="MRPSTGRHRRTRNLSVAAAVAVSAGACGVYLGLSNDGAQAATTVT
                     VSSAAQLESAVANASAGTTIQVRGGTYYPTATLKSTANGTSSARITLKAYGSEKVKIDG
                     SKLPDGSWLAGIYGDYWTVQSITWQNSPAQGFVATSSTGGIFKNLVTANNGDSGFTLRG
                     DGTTDNLVQDLDSYGNYDAANHGQNADGIAVKFGSGTGNKITGARLYNNADDGLDLWQF
                     SSPVTIEHSWAFGNGENRWNDAGFEGNGNGFKLGGGGVSVAHSVNNNAAWDNTLHGFTE
                     NSNTGAILLNRNTAYANIETGFYFATGKARLARNLAVSNAKGTAKLGSATVSAANNWDS
                     GVTTPSFRSTDATTAYGARGSDGSLPETTFLTTGSTAIGSTMD"
     gene            10001..11074
                     /locus_tag="IE242_RS30900"
                     /old_locus_tag="GCM10010365_63320"
     CDS             10001..11074
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140946.1"
                     /locus_tag="IE242_RS30900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63320"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_229859660.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 8e-63, bitscore:
                     205.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGVAELTVPEAEARVPGQQGGSLQWARDLVAPALREAVEGLPEP
                     ERLVEGYHRGWHEADGGPLRAADGRPGGKAVRPALVLLAARAVGGTAECAVPGAVAVEL
                     VHDFTLLHDDVIDGDPLRRHRPAAWTVYGTPSAVLAGDALLVVALRTLSAVPGPRGAAA
                     LRELVAALADLMRGQSQDVAFEERARVGAHEYLAMAEGKTGALMGGACALGGLLAGASE
                     HRVAGLREFGRRLGVAFQCVDDLLAIWGDSRRSGKPVGADLAARKKSLPVAVALAADSP
                     AGRRLAELYERPEPLDAADVAAAARLVEEAGGRTATEREAQRQITVALRALAAAEPLPE
                     VYRQLHSLAMATTRRDR"
     misc_feature    complement(11326..11340)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            11331..12101
                     /locus_tag="IE242_RS30905"
                     /old_locus_tag="GCM10010365_63330"
     CDS             11331..12101
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019436127.1"
                     /locus_tag="IE242_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63330"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_229859665.1"
                     /transl_table=11
                     /translation="MSFTVPRGVIVGLLGPSGCGKTTLLRSVVGIQPSTAGHVQVLGLP
                     AGARGLSTRIGYVTQAPSVYPDLTVLENLRYFSAALGLRGWRREDAVVRVVKEVDLAPY
                     ADKPVAWLSGGQYSRVSLAVALLGSPELLVMDEPTVGLDPMVRRELWGVFQRLAEEGTT
                     LLVSSHVMDEADHCDRLLLMRAGRLLASAGREDVLEHTGCERVEDAFLDLVSASAAAEE
                     ADSARTAVGRVPPPMLTDESADSDRPYFSSGARC"
     gene            12095..12862
                     /locus_tag="IE242_RS30910"
                     /old_locus_tag="GCM10010365_63340"
     CDS             12095..12862
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548047.1"
                     /locus_tag="IE242_RS30910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63340"
                     /product="ABC transporter permease"
                     /protein_id="WP_189865180.1"
                     /transl_table=11
                     /translation="MLNPAVRRSRALPFSPGITTATAGRVLLQIRRDRGSTALMLVIPC
                     MLMVLLKLVFHGAEDSFERVGPQVFGIFPVIVMYLVASVSTLRERSTGTAERLLTLPVQ
                     RLDIVLGYSLAFAFLAVLQATLSTLLAIGPLGLDIKGPAVLLMVIAMLGALLGLALGLL
                     ASGFARNEFQAVQFLPAGVLPQFLVCGLFVPREEMHGSLAALAKVMPMTYAVQAATQAA
                     DHKGITGIFVRDALLILLCVIGVLMASAATLKR"
     gene            complement(12954..13190)
                     /locus_tag="IE242_RS30915"
                     /old_locus_tag="GCM10010365_63350"
     CDS             complement(12954..13190)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_63350"
                     /product="hypothetical protein"
                     /protein_id="WP_189865182.1"
                     /transl_table=11
                     /translation="MFSLRRAVTVCAAAAALAVAAAPAAPAASAPAAGSFPPPGDEYHH
                     HHRERPLNFGPFEVPRRGDISGGMSWNFGNGRG"
     misc_feature    complement(13206..13220)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.39"
                     /tool="antismash"
     gene            complement(13478..14560)
                     /locus_tag="IE242_RS30920"
                     /old_locus_tag="GCM10010365_63360"
     CDS             complement(13478..14560)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="IE242_RS30920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63360"
                     /product="hypothetical protein"
                     /protein_id="WP_189865184.1"
                     /sec_met_domain="T1TS (E-value: 2.3e-75, bitscore: 248.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALSLAGADFPPHWCPLESAVHPRVRQVERRAEAWIRDSGMCASE
                     EERAWAVATHSTDFYARFAPDAADDERLLATSLWVYWGFAFDDARCDSGPLSSRPAQFN
                     ALAGRIQRAVEAPGADLDGERFAAPLQDIVRRFRALGTPSQVRRFAHAHRAWLSGAAWQ
                     IGNQAVGRMPGPDEYLAMRLLASGGEPTFAMLELATGQEVPDGEMQRPAVRALTEMAVL
                     VAALDNDRHSLRKEAERDLADQNVFTVLMQHRSLSLPEAVEEAVRLRDRVLLRFLRLHD
                     RVRPGASAALGTYLQGLRYGMRGNAEWGLRVPRYLSLGRVPDAMDDDLPVRWAEEPADT
                     SPYAPAGLPAVAWWWDEDLA"
     misc_feature    14555..14565
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(14780..15595)
                     /locus_tag="IE242_RS30925"
                     /old_locus_tag="GCM10010365_63370"
     CDS             complement(14780..15595)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474876.1"
                     /locus_tag="IE242_RS30925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63370"
                     /product="pectate lyase"
                     /protein_id="WP_189865186.1"
                     /transl_table=11
                     /translation="MTSPAEHRVRHPRRRTVRRHALLSGLGALGLTGAALVGGSTLPTA
                     SAATWPTPTGSQAVSSTISVSGTRDGGMVRYYGSGNLAGDGQEEGQDPIFKLANGATLK
                     NVIIGAPGADGIHCEGNCTLQNVWWEDVGEDAATFRGGNGTVATVTGGGAKKAADKVFQ
                     HNGGGTVNISNFAVSEFKTLYRSCGDCSTQYTRKVNLNTIEVTGTGSTARLVGINVNRN
                     DVATLRRITISNDSGRKVVPCQKYNNTTAVGTGPDSTNCLYSSSDITYR"
     gene            complement(15721..16608)
                     /locus_tag="IE242_RS30930"
                     /old_locus_tag="GCM10010365_63380"
     CDS             complement(15721..16608)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477756.1"
                     /locus_tag="IE242_RS30930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63380"
                     /product="hypothetical protein"
                     /protein_id="WP_189865188.1"
                     /transl_table=11
                     /translation="MRDVHDELRARLREAAAAHEPDRARILARIERGMSEEARPARSAH
                     RARHPLSGWAGWMRLAGATAAVAGILGVGGYAVASAVKGDEPADRTVVTSPTPVVSPDA
                     TSRAPLPPDDPAPTGGTSEQPSGTPSAEGSEEPKDRESKGSASSRPPVARDVESGPLWS
                     DGSVDPHSNEFWAQSNVTLKTEEKLTALTVELRIALTEGVTSTGAWRSLPERDFTLTTG
                     EEDGFLVYRWVLKEGRTVPAGEWVFAGQYDHERGGRDAGDDDYTITATADGEQRAVGGD
                     FARQGDDDSDEGDS"
     gene            complement(16605..17168)
                     /locus_tag="IE242_RS30935"
                     /old_locus_tag="GCM10010365_63390"
     CDS             complement(16605..17168)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661343.1"
                     /locus_tag="IE242_RS30935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63390"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_189865410.1"
                     /transl_table=11
                     /translation="MGTVVDDAASVEFHAFFERHYAELARLAALLTGEADAADDLAADA
                     LLALWHRWDRVRAADHPVAYARGVVANLARTRIRSAVRERRRITLFWSQREEKTENPDV
                     PGMVDVQEALRRLPFRKRACVVLRHAFDLSEKDTALALGVSVGTVKSQTSKGMAELQRL
                     LGTQDAPRQVHRAAVSGATGGRNR"
     misc_feature    complement(17321..17336)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(17367..17384)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            17459..18910
                     /locus_tag="IE242_RS30940"
                     /old_locus_tag="GCM10010365_63400"
     CDS             17459..18910
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987786.1"
                     /locus_tag="IE242_RS30940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63400"
                     /product="NCS2 family permease"
                     /protein_id="WP_189865190.1"
                     /transl_table=11
                     /translation="MSDTQQEAGPPKAGPPAATGVDRFFQVTARGSTFAREIRGGFATF
                     FTMAYILVLNPIILGSAEDKFGHRLDGAELATATALVAAVMTIIMGVGGNLPLALAAGL
                     GLNAVVAFQIAPLMSWADAMGLVVLEGLLICVLVVTGLREAVMHAIPQPLKQAIGVGIG
                     LFIAFIGFVDAGFVSRIPDAANTTVPVQLGGTGALSGWPVLVFCLGVLLTVALLARGVR
                     GAILISILVMTAVAIVIEKAADVTSWGLTSPKIPDDLVAAPDFGLIGGFSLFGAFGETT
                     VITVVLLIFTLLLSDFFDSMGTVVGVSAEAGLLDEAGRVPNLGRVLLIDGAAAVAGGAS
                     SASSATSYVESAAGVGEGARTGFANLVTGGLFACALFLAPLLTMVPMQAAAPALVAVGF
                     LMMTQVKQIDWERYEIAIPAFLTIAVMPFTYSITNGIGAGFVSYVLIKTVLGRAREVHW
                     LLWGTSALFLVYFAIDPVEQLLGVR"
     gene            complement(18956..20413)
                     /locus_tag="IE242_RS30945"
                     /old_locus_tag="GCM10010365_63410"
     CDS             complement(18956..20413)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020130473.1"
                     /locus_tag="IE242_RS30945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63410"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_189865192.1"
                     /transl_table=11
                     /translation="MNKTIRRTAVFTLLLVFALLIRATWVQFYDGQALADDKNNRRNVM
                     EQYAQPLGDIIVAGEAITGSARTQGSDLHYKRTYTDGELYAAVTGYGSQVYGATQLEGI
                     YKDLLDGTDTELKNPLEVLTKEPAAPGDVVTTIEPDVQKAAYEALGDKKGAAVAIDPAT
                     GRILAVVSTPSYDPGTISGSGSDDAAAWQKLTKDEDKPLVNRALRQPLPPGSTFKLVVA
                     AAALEDGLHGSVDERTDSPDPYTLPGTTTVLRNESSSAPCENATIRTALQYSCNNVFAK
                     LAVDLGQDKVRAMAEKFGFDDELDVPVRAYASVYPSDMDEAQTALSGIGQFDVTATPLQ
                     MAMVSAAIANDGKLVSPHMVAQTSDADGTVLEDYDGDTETKEIVSSSTAEQLRSAMQTV
                     VEEGTGTNARVSGATVGGKTGTAQHGENNSKTPYAWFTSYAKSDTGDDEVAVAVIVEQS
                     DAARSEVSGNGLAAPVAQAMMEAALEG"
     misc_feature    20398..20412
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.85"
                     /tool="antismash"
     gene            complement(20504..21277)
                     /locus_tag="IE242_RS30950"
                     /old_locus_tag="GCM10010365_63420"
     CDS             complement(20504..21277)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381154.1"
                     /locus_tag="IE242_RS30950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63420"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_189865194.1"
                     /transl_table=11
                     /translation="MSAGETGGGAQVKSAVRTVELLEYFAGRPGMHSLASVQEAVGYPK
                     SSLYMLLRTLVDLGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAVARPTLDRLSDDT
                     TETIHLARLDGTNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATHTDEQVRKL
                     LPETLPALTEHTITDREKLIEELHQIREQGFAVDREENTLGLRCFGVAVPYRTPARDAI
                     SCSVPVARLTPAHEQMVKDALFDARDRLTLATRRL"
     misc_feature    complement(21329..21343)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            21417..22949
                     /locus_tag="IE242_RS30955"
                     /old_locus_tag="GCM10010365_63430"
     CDS             21417..22949
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187946.1"
                     /locus_tag="IE242_RS30955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63430"
                     /product="aldehyde dehydrogenase (NADP(+))"
                     /protein_id="WP_268249510.1"
                     /sec_met_domain="Aldedh (E-value: 1.4e-42, bitscore: 139.3,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAAPVWSVDPRTGKQREQVAVEATAQGVDEAVRAAHAARGALAD
                     RTVRSAFLRTAADRLEGAKDRLVELADAETALGPVRLTGELARTCYQLRAFADIVDEGA
                     FLDVVINHPDDTATPPIPDLRRYKVPLGVVAVYSASNFPFAFSVAGGDTASALAAGCPV
                     VVKAHPDHPGLSEQVAAELRAAAAEHGIPEGVVGLVHGFEAGVELVKHPLVAAAGFTGS
                     VRGGRALFDAAAARPVPIPFHGELGSLNPVVVTEAAAAERAEAIGAGLAGSMTLGVGQF
                     CVKPGLVLAPAGEAGDRLLKSFTEAVGEVDAGVLLDHRMRDNFIAGVAERAELPGVEAP
                     VTAGEGDEHTVRPGFLTVPAEKLAVEGGEHELLLEECFGPLTVVARYADDTEAQALLAR
                     LPGNLTATVHLSEEEAAGEGRGAEILAELTPLAGRVLVNGWPTGVAVAPAQHHGGPYPA
                     TTSTSTSVGGTAIERWLRPVAYQGAPEALLPPELRDDNPLGLPRRFNGRLER"
     gene            complement(23025..23939)
                     /locus_tag="IE242_RS30960"
                     /old_locus_tag="GCM10010365_63440"
     CDS             complement(23025..23939)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072692.1"
                     /locus_tag="IE242_RS30960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_63440"
                     /product="YceI family protein"
                     /protein_id="WP_189865198.1"
                     /transl_table=11
                     /translation="MVLGLLRRRRSRSGSGAAAGLTVPLPSGAGAIGCEVVDPMGQPMG
                     GAEVTVTALDSHRVATRGTTDPFGFFMATLPPGTYSMMIAAEGLTPTRQDVEVVAGVSA
                     PTLRVALEPARQLELPAPGTWLFDPPHTAIRFIAKHVGMAHVHGRFTRFEGGIQVAQNM
                     ADSRVSARIDASSLTTGNNTRDGHLRSADFLDVERYPFIDFTSTRFVYRGGSKWTLQGT
                     LSMHGTSRSVNLDTTYLGTVNGGYEQELRCAALAKAELHREDFTLNYRSMLARGIAVVG
                     PTVQLELDVQAMYRTHDTPTPPE"
     misc_feature    complement(23979..23993)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.78"
                     /tool="antismash"
ORIGIN
        1 cccgtgacgt gcggcgcctg gacgacgaga tccccgagtc gtggatcacc tggcccgagg
       61 cgtgagtccg taccacctcc gcccctcccc ccgagcttga aaggacctct tctcatgcgt
      121 acccgcacat ggcatggacc tgccactcgc accaccgccc tcgccggctg caccgcgctc
      181 gtcctcgcgg tcaccgccac cgccgcctcc gccaccggtc acggtcactc ccgcgaccac
      241 gcccggcaga ccctcgccgc gggcgacggc tgggccgccg agggcaccgg cacgacgggc
      301 ggcgcggccg cctccgccga gcacgtgtac acggtcacca cctgggacgg gttcaaggcc
      361 gcgctggccg acggcggcga cgccccgaag atcgtcaagg tgaagggcgt catcgacccc
      421 gtcgccgagg gttgcgcctc gttcgaggcc gagggctacg acttcgacgc ctacctggag
      481 aagtactccc cggagaactg gggcctggac gaggacctgt ccggtgagcc cgccgacagc
      541 cccgagggcc tgcgcgcggc ctccgccgcc gcccaggaca aggccatcaa ggtcaacatc
      601 cccgccaaca ccaccatcgt cggcgtcggc agagacgcgg gcatcagagg cggcagcctc
      661 cagatccggg gcgtggacaa cgtcatcgtc cgcaacctca ccatcgaggc ccccctcgac
      721 tgcttccccc agtgggaccc gaccgacggc gacaacggcg cctggaactc cgagtacgac
      781 gcggtcgtcg tgtatggctc cacccatgtg tggatcgacc acaacacgct caccgacggc
      841 cgctaccccg acagcaccct gcccacctac ttcggccaga cctaccagca gcacgacggc
      901 ctgctcgacg tggtgcgcgg cgccaactat gtgacggcgt cctggaactc gttcgagaac
      961 cacgacaaga cgatcctcat cggcaacagc gacagcgccg gcgccaccga caccggcaag
     1021 ctcaaggtca ccctccacca caaccgcttc aagggcatcg tggagcgtgc gccgcgggtc
     1081 cgcttcggcc aggtcgacgc gtacaacaac cacttcgtgg tcaccaagga ccagaagtac
     1141 ggctactcct tcggcgtcgg cgcctcctcg cagctgtacg ccgagaagaa cgccttctcc
     1201 ctcccgtccg gcatcagcgc cgccaagacg ctgaagaagt ggagcgaggc cccgctcacc
     1261 gcgaagaaca actacgtcaa cggcaagcgg acggacctca tcgccgtcca caacgcggag
     1321 atcccggggg agaccctcca gtcggacgcc ggctggacac ccacgctgcg gaagagggtc
     1381 gactccccgc tcgccgtgcc gctgatcgtc gccctgggcg cgggcgccgg gaaggtgcgg
     1441 tgaccgtgga acggccgctg gaacggccct ccctcagcag acgatcgttc gtcggcgcga
     1501 gtgccggtgc cggagccgcg ctcgccctgg cactcgcctc tcccgcccgg gcccacggac
     1561 ggcgctcccc cttcggccgg tacggctccc cgcgcgcgcg gctgaacggg cagaccctgt
     1621 acgtccaccc cggcggcctc ggcgaccaca ccaccgtgca ggccgccgtg gacgcggcgg
     1681 gcagcggctg cacgctggtc atcgcgcccg gcacctaccg tgagacggtc gcggtcagca
     1741 cggcccgcac ggagatgacc tggctcgggg cctcggacga cgcccgcgac gtcacgatcg
     1801 tgtacgacaa cgcggccggc acccccaagc ccgacggttc gggcacctac ggcaccagcg
     1861 gctcggccac caccaccgtg caggccgacg gcttcaccgc ccggcacatc accttcgcca
     1921 acgactggct gcgcgccgac caccccggtt tcagcggcac ccaggccgtc gcgatcaagg
     1981 tgcagggcga ccggtccgcg ttccaccact gccggttcct cggccaccag gacaccctgt
     2041 acgccgacac gagggcgctc ggcaccttcg cccggcagta ctacgcgcac tgctacgtcg
     2101 agggcgacgt ggacttcgtg ttcggccggg ccaccgccgt gtacgagcac tgccacttcc
     2161 gcaccctgat ccgtacggac ctgacgagcg cgccctacgg cttcgtcttc gcgccgtcca
     2221 ccgcgggcgc caacccgcgc ggctacctgg tgacccacag ccgggtgacg agcgaggccc
     2281 cggacggcta ctacaagctg gcccgcccct gggtgcccag ctccgacacc accgcccgcc
     2341 cgatgctgac cgtgcgcgag acccgcctcg gcgccggcat cgacgcggtg gcgccgtaca
     2401 ccaacatgtc gtccgggtac ccgtggcagg accagcggtt cgccgagtac cgcaacacgg
     2461 gcccgggcgc ggccgtcacc gtcccggaga accggccgca gctcacgcgc gcggaggcgc
     2521 ggtcacacac ccgtgaggcg tacctcggcg actggacgcc ctggaaggtg cgctgaggtg
     2581 cggcggcgca ccctgctcac cgggatcgcc ggcggcctca cggccgtcgg cgtcaccccc
     2641 gcccccgccc tcgccgcccc gcgccgccgc cgggtcctgc acgtccgccc cggcggccgc
     2701 ggcgaccaca ccaccgttca ggccgccgtg gacgcggccg agggccccgg ctggacggtc
     2761 gtcgtgcacc cgggcaccta ccgcgaggtc gtgaccgtcc ccgccgaccg gcccggcctc
     2821 accctgcgcg gcgccaccgg cgacccgcgc gacgtcgtca tcgtgtacga caacgccaac
     2881 ggcactccga agcccgacgg ttcgggcacc tacggcacgg cgggctccgc caccttcacc
     2941 tcggcggccc ccggcctcac cgtccgcgac ctgaccctcg ccaacgactg gctgcgcgcc
     3001 gaccacccgg agatcaccgg cacccaggcg gtcgccgcgt acctgacggg ggaccggacg
     3061 cacttcgaca acgtgtggct gctggcccac caggacaccc tcttcgtcga cacgaccgcg
     3121 ctcgacgtct tcgaccggca gtacttccac cgctgccaca tcgagggtga cgtcgacttc
     3181 gtcttcggcc gggcgaccgc ggtcttcgag cactgccgct tccacacggt gcggcgggac
     3241 gtcgacttca cacccaaggg catggtcttc gccccctcca cggcccgcgc caacccccac
     3301 ggcatcctgg ccgtccactg ccgcgtcacc tccgccgccg aggacggggc gtacaagctg
     3361 gcccggccct gggtgccgtc gtacgagacc accgcctggc cctccctcgt cgtccgggac
     3421 accaggatcg ggcccggcat cgacgcggag gcgccgtaca cgaacatgcg ggaggcgtac
     3481 ccctggcaga cgatgcggtt cgcggagtac cgcaacacgg gcccgggcgc ggccgtcacc
     3541 gtcccggaga accggccgca gctcacgcgc gcggaggcgc ggtcgcacac cagggagacc
     3601 tacctcggcg actggaggcc gtatgcgtat gcctaaaacc ctggccaccg ctctgctcgc
     3661 ctgcgcctgt ctgctgctgc cgcaggcggc cccggcctcc gccgacggac ggccttcgac
     3721 gcccgagggc tgggcctccg cgggttccgg caccaccggc ggggcgggcg gcacgacctg
     3781 gacggtgcgc acgcgcgccg aactcaagga ggccctggcc aacgacggga accccaccgc
     3841 gcccaaggtg atccgcgtcg tcggcgccgt cgacggccac gaggcggacg acggcaccct
     3901 gctcggcgag caggactacg cccccggcta cgacctcacc aagtacatgt cctgcttcgg
     3961 cgaggacggc agcacctggt ccgacacccg ctacgactac tgcaagcagc agcgccagct
     4021 ccggcagacc ggttcgaaca gggagaaggc gcagatccag ctgaccgtgc cgagcaacac
     4081 caccctcgtc ggcgcgggcg acgacgcccg gctcctcggt gtcttcctga ccgtcaacac
     4141 cggcaccgac atcatcgtcc gcaacctccg cctcgaagcc cccgtcgacc acttcaccag
     4201 ctggtccccg gacgacggca gcgcgggcga ctggaacgcc cgcttcgacg cgatgaccgt
     4261 gatcaccggc aagaacatct ggatcgacca ctgcaccttc accgacggcc gcttcccgga
     4321 ccgcgaggcc cctctcggct tccacggcga gcacgtccag cgccacgacg gcctgctgga
     4381 catcgaggac ggctccgact tcatcaccgt ctccgacagc cggttcaccg accacgacaa
     4441 ggcgatcctc ataggctccg gcgacgggcg cggcgaccgg gaccgcgggc atctgaaggt
     4501 gaccttcgtc cgcaacctct tcaccggcat cgcgcagcgc gccccgcgtg tccgcttcgg
     4561 gcaggtgcac gtcgtcaaca acgtccaccg gggccgggcg gacggcaccc tgtacgcgct
     4621 cggcgccggc gtcgagtccg cgatcttctc cgagcggaac gtcttcacct atccgcgggg
     4681 cacctccgcc ctcgccgtcg cggactacgg gggcgagcgc ttccacgaca ccgggtcctg
     4741 gttcaacggc aggcccgccc ggctggacgc ggtggcgagc ggcctcggtc tgaccggcga
     4801 cgtcggctgg gacccggccg acgtgtacga ctaccgggtc ctcaggtccg cgaaggcggt
     4861 cgagcggtac gtcctgcgcc acgccggcac cgggaggccg tatgcacatc cctgagccgc
     4921 ttcgccatcc actgggccgc cggaccttcg tgacgggcgc ggccacggcc atgctgctcg
     4981 ccggagcggg ggtgggcgcg ggggcgggcc cggcacgcgc ggaggacctc gtgggcggca
     5041 acctccccga cttccacccg gccctcaagg acgagctgcg cttcccgctc gcctggggca
     5101 cctcgcccca ccgggacttc cgggcgtggc ggcgggccgc ccgggcgaag gtggaggagc
     5161 acctcctcgt cgaccggcag gacaggacgc cgtacgaccc ggagttcacc gacggccccg
     5221 gcggggacgg ctaccggcgg cagtcggtga ccgtctccct cacccgctac gaacgcgtcc
     5281 gcggcagcct gctcaccccg cacggcaggg gtcccttccc ggccgtgctg ctcctgcacg
     5341 accacggggc cagattcgac atcggcaagg agaagctggt ccggccctgg gacgacgaca
     5401 cccggctcgc ctccgcgcgg gcgtgggcgg acaagtactt cagcggccgt ttcgtcggcg
     5461 acgaactggc ccggcgcgga ttcgtcgtcc tgtccctgga cgccctcggc tggggcgacc
     5521 gcgggcccgt cacctacgag cagcagcagg ccctggccag caatttctac aacctcggct
     5581 cctcgctcgc cgggctcatg gcccgcgagg acgcccgggc cgcggggttc ctggccggcc
     5641 tggaccgggt ggacgcccgg cgcgtcgcgg ccgtcgggtt ctccatgggc gcctaccgcg
     5701 cctggcaggc cgccgcgctc agcgacgaca tcgcggccgc ggcgagcgtg tgctggatga
     5761 ccgggctgaa ggagatgatg gtgcccggca acaacacgct gcgcgggcag tcgtcgtact
     5821 acatgctcca tcccggactc gcccggcacc tcgacttccc cgatgtggcg agcatcgccg
     5881 ccccccggcc gatgctcttc ttccacggcg cccaggacac cctgttcccg gcggagggcg
     5941 tcgaggccgc gtacgagaag atgcgcgccg tgtggagatc acggcacgcg ggggagcggc
     6001 tgcacaccaa ggtctggccg gagctgggcc atgtgttcac cgcgcccatg caggacgagg
     6061 tcttcacatg gctggacgct gtgttgtgac gcaccggtgc ccgtgaccac atacgtatac
     6121 gtggtcacgg gcaccgtcac gccggccgat ggaccgtcag tcggctcgcc ccaccgcctt
     6181 gatcgactcc agcgtcggca ccaccggcac gatcgtcccg tccgccgcga acctcatacg
     6241 gtcgatcgtc gtctcccggt gcgtgccgtc accgcccgcc ttaccaggac cgttgagcgc
     6301 gaaccggtgg tagaccatgt accagtcgtc ggtacccggc acgttcacca ccgagtggtg
     6361 gccggtggcc ttgatcccgt actcgggccg cttggacagg atcgtgcccc gcttggtcca
     6421 cgggccgagc ggggacggcc cggtcgcgta cgccacgtgg tagttctcgc tgcgggtgtc
     6481 gtcctcggac cacatgaagt agtacgtgcc cttgcgcttg accacgaagg agccctcccg
     6541 gaagttgtcc ggggtgatgt ccttcacctg cgccgcgtcg aacgacacca tgtcgtcgtt
     6601 cagggggacg acgtacccgc gcccgttccc ccagtacagg taggacttcc cgtcgtcgtc
     6661 cgtgaagacc gccgggtcga tcatctggcc gccggggaag tccgtcttgc cgatgagcgg
     6721 cttgcccagg gcgtccttga agggaccggc gggggagtcc gcgaccgcca caccgatctg
     6781 ctgttcggcg cagaagtaga agtagtactt gccgtcgcgc tcggcgatcg cgggggccca
     6841 ggcgttcttg tcggcccagg acacgtccgg tcccaggtcg aggatcacgc catggtcctt
     6901 ccagtggacc aggtccttcg acgagaacgc cttgaactgt gtaccgcccc agccggcgaa
     6961 gccgtccgtc gtcgggtaga tccagtagcg gccgtccatg taccggacgt ccgggtcggc
     7021 gtacagcccc ggcaggaccg ggctgcgggt cggcacggcc tcgaccgtcc aggtgcggcg
     7081 cgtgccgtcc gccgccgtca ccgtgtacgt ctgcggcttg cggaagtcgc gccgcgtacc
     7141 ggacctgggg ctcaccgtcg cgccctcgcc cacccacagc ttcggggcga ggcggcgcag
     7201 gtcggcgtcg ggctccatgg gcaggaccac cttggaggac tcctcggtga cgaccgcgta
     7261 ccccttctgg ccgcgcgccg tggcgtccac gacggacgtc gggctcaccg ggtaggcggc
     7321 cagcagccgg tcgtactcct cctgcgtcac cgggatcacc gtgccgtgcc gcgggctcgc
     7381 cgggagctgg tagtcctccg acatggtcca ctcgcccgag tccaggtccg tcgtctcgaa
     7441 cggcacgtag ccgcggccgc cgtactcgtc gatgaacagg taccacttct cctcggtgtt
     7501 ggacttgaag accgtcgggc cctcaccgcg ggacaggtcg ccgttgccga tgcagtccgc
     7561 gacgaagtcg tacgaggtgt cggtgagcga ggtggacttc tcgccggtga tgaacttgga
     7621 gcaggggctg gaggagctgg ggttccgctc gtccttggtg tagcggtagt acgtgccctc
     7681 gtgctccacc accgtcgagt cgatcaccga gtagccggga tcgctccaga tctgcggctc
     7741 gctgaaggtg cggaagtcct tggtggtggc gtacatcatg cggttgtacg acgagccggt
     7801 gtggtccggg tcgtcgtcgg cgtacagctt cgacgcccag aagacgacgt acgcgtcgag
     7861 cgtgtcgtcc cagtaggcct ccggcgccca ggtgttgccc gcgttgtccg gggagacccg
     7921 caccaggcgc tggtcggtcc agttcaccag gtcggtggac tcccaaatca tgatcgactt
     7981 gctgccgtgc cgctggacat cgtcccagct gccgctggag ctgcggtaca tgcgcaggtc
     8041 cgtggcgatc atgtagaacc tgtcgccctc gggggagcgg atcacgaacg ggtcgcgcag
     8101 gcccttctcg ccgatggtgg aggtgagcac cggcttgccc gcgttgagct cacgccagtg
     8161 cagggcgtcg ttgccgcggc tgagggcgta gcggatctgc tcgccgtcgg cggttccctc
     8221 gcccgtgaaa taggcgaaga gatagccggc gtactggggt ttcttcactg ggtgcccttc
     8281 ggcgtgggcc caaccggacg gcgcccccag caggctcacc aggagaggca cgagagccag
     8341 caggggcagc aggagcgtgt gagcggtacg acgcatgaca catcctgtgg gagtctggtg
     8401 gattctgttg acggttgacg accttcggag tgtcaccagc ggggcacggt gcgtcaatcg
     8461 gtgtgcggga gacggcgagg gcgaaaactt tcgactctgt tgcgagtggg cggcaacctt
     8521 tttcggcgcg gcggcgacga gggggaagag gcgggccggt gtggcccctc cggcccgcct
     8581 cgcgacccgt agcccatgga aaggaacccc cgtgcgcccc agcaccggac gccatcgcag
     8641 aacccgtaac ctgtcggtcg ccgccgcggt ggccgtctcc gcgggtgcct gcggcgtcta
     8701 cctcggcctg tcgaacgacg gagcccaggc cgccaccacg gtcaccgtct cctccgccgc
     8761 ccagctggag tcggccgtcg cgaacgcgtc cgccggcacg acgatccagg tccgcggcgg
     8821 cacgtactac ccgacggcga ccctcaagtc gacggcgaac ggcacctctt cggcccgtat
     8881 cacgctcaag gcgtacggca gcgagaaggt gaagatcgac ggctcgaagc tccccgacgg
     8941 gtcctggctc gccgggatct acggcgacta ctggaccgtc cagagcatca cctggcagaa
     9001 ctccccggcc cagggcttcg tcgccacctc ctccaccggc gggatcttca agaacctcgt
     9061 caccgcgaac aacggcgact ccggcttcac cctgcgcggc gacggcacga cggacaacct
     9121 cgtgcaggac ctggacagtt acggcaacta cgacgccgcg aaccacggcc agaacgccga
     9181 cggcatcgcc gtcaagttcg gctccgggac aggcaacaag atcaccggag cccgtctcta
     9241 caacaacgcg gacgacgggc tggacctctg gcagttctcc tcaccggtca ccatcgagca
     9301 ctcctgggcg ttcggcaacg gcgagaaccg ctggaacgac gccgggttcg aaggcaacgg
     9361 caacggcttc aagctgggcg gcggcggagt ctcggtcgcg cactccgtca acaacaacgc
     9421 ggcctgggac aacaccctcc acggcttcac cgagaactcc aacaccggcg caatcctgct
     9481 gaaccgcaac acggcgtacg ccaacatcga gaccggcttc tacttcgcca ccggcaaggc
     9541 ccgcctggcc cggaacctcg ccgtgagcaa cgcgaagggg accgcgaagc tgggctccgc
     9601 cacggtctcc gcggccaaca actgggacag cggggtcacc accccgtcct tccgctccac
     9661 cgacgcgacg accgcgtacg gcgcccgcgg gtccgacggc tccctgccgg agacgacgtt
     9721 cctgaccacg ggctcgacgg ccatcggctc gacgatggac tgatctcccg cccgtacggt
     9781 ccggtcgtgc ccgtacggcc ggaccgcgcg cccgtacggc cggaccgcgc ccgtacggcc
     9841 gccttgcccg atgagcgggc tatcagggcg ttgtgggctg tccaggcggt tttcggtgtg
     9901 cgggagggcg caccggtgtg gccggtggcg gagtcccggg cccgtggtgt ctcgtgagct
     9961 gccgtaggga tcttgctgat gagggctgag gtggctacgg gtgagcggtg tggcggagct
    10021 gaccgtacct gaggcggagg cgcgcgttcc gggacagcag ggcggttcgc tgcagtgggc
    10081 gcgggacctg gtggcccccg cgctgcggga ggcggtcgag ggactcccgg agccggaacg
    10141 gctcgtcgag ggataccacc gcggctggca cgaggcggac ggcggaccgc tgcgcgcggc
    10201 ggacgggagg ccgggcggca aggcggtgcg gccggcgctg gtgctcctcg cggcccgggc
    10261 ggtcgggggc acggcggagt gcgcggtgcc gggggcggtg gcggtggaac tcgtccacga
    10321 cttcaccctg ctccacgacg atgtgatcga cggcgatccg ctgcggcggc accgccccgc
    10381 cgcctggacg gtctacggca ccccgtccgc cgtcctggcg ggcgacgcgc tgctggtggt
    10441 cgccctgcgg acgctgtcgg cggtacccgg gccccggggc gccgccgcgc tgcgggaact
    10501 ggtggcggcc ctggccgacc tgatgcgggg ccagagccag gacgtcgcct tcgaggagcg
    10561 tgcccgggtc ggtgcccatg agtacctggc catggcggag ggcaagacgg gggcgctgat
    10621 gggcggcgcc tgcgcgctgg gaggcctgct ggcgggggcg agcgagcacc gggtcgccgg
    10681 tctgcgggag ttcggtcggc ggctgggcgt ggccttccag tgcgtcgacg acctgctggc
    10741 gatctggggc gacagccggc gcagcggcaa gcccgtcggc gcggacctcg ccgcccggaa
    10801 gaagtcactg ccggtggcgg tggcgctggc cgccgacagc ccggccggcc gccggctggc
    10861 ggagctgtac gagcggcccg aaccgctgga cgccgccgat gtcgcggcgg ccgcgcggct
    10921 ggtggaggag gccggaggac gcacggccac ggaacgggag gcccagcggc agatcacggt
    10981 cgccctgcgg gcgctggcgg ccgcggagcc gctccccgag gtgtaccggc agctgcactc
    11041 cctggcgatg gcgacgaccc ggcgcgaccg ctgaattcgg cgcggcatta cgcattcctg
    11101 gcccgcgaca tggctttttc catacgtaac catgcacccg gccgggcgtt tccataccgg
    11161 ggccgttgtc gccgacgacg gcagcggttc tcgggcagca gtgaagcagc gaagcagtga
    11221 agcagcgaca gaaggatatt cccatgacag gcccggagcc ggccggtccg ccggccgtca
    11281 gcgtttttgg tctgcatgtt tccatcggcg agaatgccat tgtccaggac gtgagtttca
    11341 ccgttccgcg cggtgtcatc gtcggactgc tgggaccgag cggatgcggg aagacgacgc
    11401 tgctgcggtc cgtcgtcggt atccagccca gtacggcggg gcatgtgcag gtgctgggac
    11461 tcccggccgg cgcacggggc ctgagcaccc gtatcggcta tgtcacccag gccccgtcgg
    11521 tctacccgga cctcacggtg ctggagaacc tgcgctactt ctccgcggcg ctgggactgc
    11581 ggggctggcg ccgcgaggac gcggtggtgc gcgtggtgaa ggaggtggac ctggccccgt
    11641 acgccgacaa gccggtcgcc tggctgtcgg gcgggcagta ctcccgcgtc tcgctggcgg
    11701 tggcgctgct cggctcgccc gaactgctgg tcatggacga gcccaccgtc ggcctcgacc
    11761 ccatggtgcg ccgcgagctg tggggtgtct tccagcggct cgccgaggag ggcacgaccc
    11821 tgctggtctc cagccacgtc atggacgagg ccgaccactg cgaccggctg ctgctcatgc
    11881 gcgccggccg gctgctcgcc tccgccgggc gcgaggacgt cctggaacac accggctgcg
    11941 agcgggtgga ggacgccttc ctggacctgg tgtcggcctc cgccgcggcc gaggaggcgg
    12001 acagcgcccg gacggccgtc ggccgggtgc ctcccccgat gctcaccgac gagtcggccg
    12061 actccgaccg cccgtacttc tcctcggggg cacgatgctg aatcccgctg tccgcaggtc
    12121 ccgcgccctg ccgttctcgc cgggcatcac caccgccacc gcgggccggg tgctgctcca
    12181 gatccgccgg gaccggggca gcaccgccct gatgctggtc atcccctgca tgctgatggt
    12241 gctgctgaaa ctggtgttcc acggcgcgga ggacagcttc gagcgggtcg gcccccaggt
    12301 cttcggcatc ttcccggtca tcgtgatgta tctggtcgcc tcggtctcca ccctgcgcga
    12361 gcgcagcacc ggcaccgccg agcggctgct gaccctgccc gtgcagcgcc tggacatcgt
    12421 gctcggctac agcctcgcgt tcgcgttcct ggccgtgctc caggccacgc tgtccaccct
    12481 gctggcgatc ggtccgctgg gcctggacat caagggcccg gcggtgctgc tcatggtcat
    12541 cgcgatgctg ggcgccctgc tggggctggc gctgggcctc ctggcgagcg gcttcgcccg
    12601 caacgagttc caggcggtgc agttcctgcc ggccggggtg ctgccgcagt tcctggtgtg
    12661 cgggctgttc gtgccgcggg aggagatgca cggctcgctc gcggccctgg ccaaggtgat
    12721 gccgatgacc tacgcggtgc aggccgccac ccaggccgcc gaccacaagg gcatcaccgg
    12781 gatcttcgta cgggacgccc tgctgatcct gctgtgcgtg atcggtgtcc tgatggccag
    12841 cgccgccacg ctcaaacgct gaggcgcggg aacagggcgg gaaccggaag ggtgcgggtg
    12901 ggatgcgcac gcgcgcaccc cacccgcacc cttccggctc ttcagaccgg cggtcagccg
    12961 cggccgttgc cgaagttcca cgacatgccg ccgctgatgt cgccgcggcg cggtacctcg
    13021 aacgggccga agttcaacgg acgctcacgg tggtgatggt ggtactcgtc gccgggcggc
    13081 ggaaaactcc cggcggccgg agcggaggcg gccggtgccg cgggggcggc ggccacggcg
    13141 agcgcggccg ctgcggcgca cacggtcaca gcacggcgga gggagaacat cgacgactcc
    13201 tcgggagaaa agggaatcca gcagatcggc aacgatgcta gtgatatgcg ccgcaggccc
    13261 ggcggagaaa ttccgggccg tccctcgaat gagggcggga aaccgaaatg cgggcgcaaa
    13321 gggcccgaag gtcgcggaga cggagaggag tgagtggaga ggagtgagtg gagaggggtg
    13381 agtggagagg ggtgcgcggt gagcggaatc gggcggcgga aaggccgggc ggctcacggc
    13441 tctcatgtgg gcgcatcgcc ttttccccgc gacccgttca ggccagatcc tcgtcccacc
    13501 accacgcgac ggccggcagt cccgcggggg cgtacgggct ggtgtccgcg ggttcctcgg
    13561 cccaccgcac cggcaggtcg tcgtccatgg cgtcgggcac ccggcccagg ctgaggtagc
    13621 gcggcacgcg cagcccccac tcggcgttgc cccgcatgcc gtaccgcagg ccctggagat
    13681 aggtgccgag cgcggccgag gctcccggcc gtacccggtc gtgcagccgc aggaagcgca
    13741 gcagcacccg gtcccggagc cggacggcct cctccaccgc ctcgggcagg gacagcgacc
    13801 ggtgctgcat cagtacggtg aagacgttct ggtcggcgag gtcccgctcg gcctccttgc
    13861 gcagtgagtg ccggtcgttg tccagggccg ccaccaggac ggccatctcc gtcagcgccc
    13921 gcacggccgg ccgctgcatc tccccgtcgg gcacctcctg cccggtcgcc agctccagca
    13981 tggcgaaggt cggctcgccg ccgctggcga gcagccgcat cgccaggtac tcgtccgggc
    14041 cgggcatgcg cccgaccgcc tggttgccga tctgccaggc ggctccggac agccaggccc
    14101 ggtgggcgtg ggcgaaccgc cgtacctgcg acggtgtgcc gagggcacgg aaacggcgga
    14161 cgatgtcctg cagcggagcg gcgaaccgct cgccgtccag gtccgcaccg ggcgcctcga
    14221 ccgcccgctg gatccggccg gccagcgcgt tgaactgcgc gggccgcgag ctcagcggcc
    14281 cgctgtcgca ccgggcgtcg tcgaacgcga agccccagta cacccagagc gaggtggcca
    14341 gcaggcgctc gtcgtccgcc gcgtccgggg cgaaccgtgc gtagaagtcc gtgctgtggg
    14401 tggcgacggc ccaggcacgc tcctcctcgg acgcgcacat accgctgtcc cggatccacg
    14461 cctcggcccg cctctccacc tgacgcacgc gtggatggac cgcggactcg agcggacacc
    14521 agtggggcgg gaagtcggct ccggcgaggg agagtgccat gtcatgtccc tggagtcggg
    14581 gtggtcggtc gggaaggagc actcatcctt ctacggccgg ttccgtccag gagtgagaca
    14641 ggcgatgtcc tctcagaaac caacaccaat tggtcagtca ccgacgtgga ttgacggcga
    14701 cggccccctg gcgtcggcct tcacgaccat gagcacgacg gcacgagggc acgacgggtc
    14761 gtgaaggccg acagttcgat cacctatagg tgatgtcgga cgacgagtac aggcagttgg
    14821 tgctgtccgg gcccgtcccg accgcggtgg tgttgttgta cttctggcag gggacgacct
    14881 tgcggccgct gtcgttggag atcgtgatcc tccgcagggt ggcgacgtcg ttgcggttga
    14941 cgttgatgcc gacgagccgt gcggtggagc ccgtgccggt cacctcgatg gtgttgaggt
    15001 tgaccttgcg cgtgtactgc gtggagcagt cgccgcagga gcggtagagc gtcttgaact
    15061 cgctgacggc gaagttggag atgttcaccg tgccgccgcc gttgtgctgg aacaccttgt
    15121 cggcggcctt cttggcgccg ccgccggtga cggtggcgac ggtgccgttg ccgccgcgga
    15181 aggtggcggc gtcctcgccg acgtcctccc accacacgtt ctgcagggtg cagttgccct
    15241 cgcagtggat gccgtcggcg ccgggcgcgc cgatgatgac gttcttcagc gtcgcgccgt
    15301 tcgcgagctt gaagatcggg tcctggccct cctcctggcc gtcgccggcc aggttgccgc
    15361 tgccgtagta ccgcaccatg ccgccgtccc gggtgccgga cacggagatg gtcgagctca
    15421 cggcctggct gccggtgggg gtcggccagg tggcggcgct cgcggtcggc agggtcgagc
    15481 cgccgacgag ggcggcgccg gtcaggccga gcgcgccgag gccgctgagg agggcgtgcc
    15541 gacgcacggt gcggcggcgt gggtgacgca cacggtgctc tgctggtgaa gtcatgtccc
    15601 gtttccttcg gtgggggatc agagctgtgc ttctcgactg ctggtcgcca ccggtggggg
    15661 aagggttgcc gggtgggcgg aacttttttc cgccgcaccg tctccggcgg actcaccggc
    15721 tcacgagtcg ccctcgtccg agtcgtcgtc gccctgccgc gcgaagtcgc cgcccacggc
    15781 gcgctgttcg ccgtccgccg tcgcggtgat cgtgtagtcg tcgtccccgg cgtcacggcc
    15841 gccgcgctcg tggtcgtact ggccggcgaa gacccactct ccggccggga ccgtacggcc
    15901 ctccttgagc acccaccggt agacgaggaa gccgtcctcc tcgccggtcg tcagcgtgaa
    15961 gtcccgctcg ggcagcgagc gccaggcgcc ggtcgaggtg actccctcgg tcagcgcgat
    16021 ccgcagctcg acggtgagcg cggtgagctt ctcctccgtc ttcagggtga cgttgctctg
    16081 cgcccagaac tcgttgctgt gcgggtcgac cgagccgtcg gaccacagcg gcccgctctc
    16141 cacgtcccgt gccacgggcg ggcgggacga cgcggagccc ttcgactccc ggtccttcgg
    16201 ctcctcggag ccctccgcgg acggggtgcc gctgggctgc tcgctggtgc cgccggtcgg
    16261 ggccgggtcg tcgggcggga gcggggcgcg gctcgtcgcg tccggggaga cgaccggcgt
    16321 gggcgacgtc acgaccgtac ggtccgccgg ctcgtcgccc ttgaccgccg aggcgaccgc
    16381 gtagccgccc acgccgagga tcccggcgac ggcggccgtg gcgcccgcga gccgcatcca
    16441 gccggcccag ccgctcaggg ggtggcgcgc gcggtgcgcg gagcgggccg ggcgggcctc
    16501 ctcgctcatg ccgcgttcga tccgggccag gatccgcgca cggtcgggct catgggccgc
    16561 ggccgcctcg cgcaggcggg cgcgcagctc gtcgtgcacg tccctcatcg gttccttcct
    16621 ccggtggccc cggacaccgc tgccctgtgc acctgccgcg gggcgtcctg cgtcccgagc
    16681 agccgctgga gttcggccat ccccttcgac gtctggctct tcaccgtacc gaccgacacg
    16741 cccagcgcga gcgcggtgtc cttctccgag aggtcgaagg cgtgtcgcag caccacgcac
    16801 gcccgcttgc ggaacggcag tctgcgcagt gcctcctgga catcgaccat gccggggacg
    16861 tcggggttct cggtcttctc ctcgcgctgc gaccagaaca gcgtgatccg ccgccgctcg
    16921 cggaccgcgc tgcggatgcg ggtgcgggcc aggttggcca ccacaccgcg cgcgtacgcc
    16981 accggatggt cggccgcccg cacccggtcc cagcggtgcc agagcgcgag cagcgcgtcc
    17041 gccgcgagat cgtcggccgc gtcggcctcg cccgtcaaca gggcggccag ccgagccagt
    17101 tcggcgtagt gccgctcgaa gaaggcgtgg aactccacgg aggcggcgtc gtcgacgaca
    17161 gtgcccacgg gcgacctctc tcgctgcggc tcgacgatga cctgtgcggg ggcgcgggcg
    17221 tgcggaccgg gctcggtacg cgtgcggaca cggcccccgg gttcgacccg gcgtcgcatg
    17281 atcgtttctc cggggcgagg accggaagcg tagcagtgtt tcgtacgggc cttcgaacgg
    17341 tgtgtggcct accgaacttg gattccgtaa cacgcggaaa acctgaaccg cacgcggcgc
    17401 gggaacaatc cagccagcaa ccgcacaccc ggcacgcagg tttcgaggag tatccgccat
    17461 gtccgacacg cagcaggagg ccggcccacc gaaggccggt ccaccggcag ccaccggagt
    17521 cgaccggttc ttccaggtca ccgcccgggg ctccaccttc gcccgcgaga tacgcggcgg
    17581 cttcgccacg ttcttcacga tggcgtacat ccttgtcctg aatcccatca tcctgggcag
    17641 cgccgaggac aagttcggtc accggctcga cggggccgaa ctggccaccg ccaccgccct
    17701 ggtggccgct gtgatgacga tcatcatggg cgtcggcggc aacctccccc tcgcgctcgc
    17761 cgccggactc ggcctcaacg cggtcgtcgc cttccagatc gccccgctga tgagctgggc
    17821 cgacgcgatg ggacttgtcg tcctggaagg cctgctgatc tgcgtcctgg tggtcaccgg
    17881 gctgcgcgag gccgtcatgc acgccatccc gcagccgctg aagcaggcca tcggcgtggg
    17941 catcggcctg ttcatcgcct tcatcgggtt cgtcgacgcc gggttcgtca gccggatacc
    18001 ggacgccgcg aacaccaccg tgccggtcca gctcggcggc acgggcgcgc tgtcgggctg
    18061 gccggtcctc gtcttctgcc tcggcgtgct gctgaccgtc gcgctgctcg cccgcggggt
    18121 caggggcgcg atcctgatca gcatcctggt gatgacggcc gtcgcgatcg tgatcgagaa
    18181 ggccgccgac gtcacgagct ggggcctgac ctcaccgaag atccccgacg acctcgtggc
    18241 ggcgcccgac ttcgggctga tcggcggctt cagcctgttc ggcgccttcg gcgagaccac
    18301 cgtgatcacc gtggtgctgc tgatcttcac actgctgctg tccgacttct tcgacagcat
    18361 ggggacggtc gtcggcgtca gcgccgaggc cgggctgctc gacgaggcgg gcagggtgcc
    18421 gaacctgggc cgggtcctgc tcatcgacgg cgcggccgcc gtcgcgggcg gcgcctcctc
    18481 ggcctcctcc gcgacgtcgt acgtcgagtc ggcggccggc gtcggcgaag gggcgcgcac
    18541 cggcttcgcg aacctggtca ccggcgggct gttcgcgtgc gcgctgttcc tggccccgct
    18601 gctgaccatg gtcccgatgc aggcggcggc cccggcgctc gtcgcggtgg gcttcctgat
    18661 gatgacccag gtcaagcaga tcgactggga gcggtacgag atcgcgatcc ccgcgttcct
    18721 gacgatcgcc gtgatgccgt tcacctactc gatcaccaac ggcatcggcg cgggcttcgt
    18781 ctcctacgtg ctgatcaaga cggtgctcgg ccgggccagg gaggtgcact ggctgctgtg
    18841 ggggacctcg gcgctgttcc tggtgtactt cgcgatcgac ccggtcgagc agctgctcgg
    18901 ggtccgctga ggcgatgacg gccgcccccg cgcccggtcc gtacgggcgc ggggctcagc
    18961 cctccagcgc cgcctccatc atcgcctgcg ccaccggcgc cgccagcccg ttgccgctga
    19021 cctcggagcg cgccgcgtcc gactgctcga cgatcaccgc cacggcgacc tcgtcgtcac
    19081 cggtgtccga cttcgcgtac gaggtgaacc aggcgtacgg cgtcttgctg ttgttctcgc
    19141 cgtgctgggc ggtaccggtc ttgccgccga cggtggcgcc ggagacccgg gcgttggtgc
    19201 ccgtgccctc ctcgaccacg gtctgcatcg cggaccggag ctgctctgcg gtggaggagc
    19261 tgacgatctc cttcgtctcc gtgtcgccgt cgtagtcctc gagcacagtg ccgtcggcat
    19321 cactggtctg cgccaccata tgcggggaca ccagcttgcc gtcgttggca atggccgccg
    19381 acaccatggc catctgcagc ggggtggcgg tcacatcgaa ctggccaatg cccgacagcg
    19441 cggtctgcgc ctcgtccatg tcggacgggt acacactcgc gtacgcccgc acggggacgt
    19501 ccagttcgtc gtcgaagccg aacttctccg ccatggccct gaccttgtcc tggccgaggt
    19561 cgacggccag cttcgcgaag acgttgttgc acgagtactg gagggccgtc cggatcgtgg
    19621 cgttctcgca gggcgccgag gagctctcgt tgcgcagcac ggtggtcgtg ccgggcagcg
    19681 tgtacgggtc cgggctgtcc gtgcgctcgt ccacggatcc gtgcagcccg tcctccagcg
    19741 cggcggccgc gaccaccagc ttgaacgtcg aacccggcgg cagcggctgc cgcagcgccc
    19801 ggttgaccag cggcttgtcc tcgtccttgg tcagcttctg ccaggccgcc gcgtcgtcgg
    19861 agccggaacc gctgatcgtg cccgggtcgt acgacggggt ggagaccacg gcgaggatcc
    19921 ggccggtcgc cgggtcgatc gcgacggccg cgcccttctt gtcgccgagc gcctcgtacg
    19981 cggccttctg cacgtccggc tcgatcgtcg tgaccacgtc acccggggcg gcgggctcct
    20041 tggtgagcac ctccaacggg ttcttgagct cggtgtccgt gccgtcgagc aggtccttgt
    20101 agatgccctc cagctgtgtc gccccgtaca cctgggagcc gtagcccgtg acggcggcgt
    20161 acagctcgcc gtccgtgtac gtgcgcttgt agtggaggtc gctgccctgg gtgcgcgcgg
    20221 agccggtgat cgcctcgccg gccacgatga tgtcgccgag cggctgggcg tactgctcca
    20281 tcacgttgcg ccggttgttc ttgtcgtccg cgagcgcctg gccgtcgtag aactgcaccc
    20341 atgtcgccct gatcagcagg gcgaacacga gcagcagggt gaagacggcg gtccgcctga
    20401 tcgtcttgtt catgccgtcc gggaagacga acgggagggg atcagacgtt ccccggcgtc
    20461 cgttttctca tggcactctc atggatcctc acgagcgccc tgctcagagc cggcgcgtcg
    20521 ccagcgtcag ccggtcccgg gcgtcgaaca gggcgtcctt gaccatctgc tcatgggccg
    20581 gggtcagccg ggccaccggc accgagcagc tgatcgcgtc ccgggcgggg gtgcggtacg
    20641 gaacggccac gccgaagcag cgcaggccca gcgtgttctc ctcgcggtcc acggcgaagc
    20701 cctgctcgcg gatctggtgg agctcctcga tgagcttctc gcggtccgtg atcgtgtgct
    20761 cggtcagcgc gggcagcgtc tccgggagca gcttgcggac ctgctcgtcg gtgtgggtgg
    20821 cgaggagcgc cttgcccagc gacgtcgagt gggcgggcag ccggcggccc acgcgcgtga
    20881 aggggcgcag gtagtgctgc gactggcggg tggcgaggta gacgacgttc gtgccgtcca
    20941 gccgcgccag gtggatggtc tccgtggtgt cgtccgagag ccggtccagc gtcgggcggg
    21001 ccacggccac cacctcgtcg ccgtcgatgt acgaggtgcc gacgagcagc gcccgcaccc
    21061 cgatgccgta ccgggtgccc gtggcgtccg tctcgaccca gccgaggtcg acgagtgtgc
    21121 gcagcagcat gtacaggctc gacttcgggt accccaccgc ctcctgcacc gaggccaggg
    21181 agtgcatgcc gggacggccc gcgaagtact ccagcagctc caccgtgcgc accgcggact
    21241 tgacctgtgc cccgccgccc gtctcgccag ccgacatcgc ccttgacccc ttcgttcgac
    21301 gggaaatagt ctcccaagtg ttcatcaatg gagatggcgt tcagtatatc gaacgcacgt
    21361 gatggacggc gtacgaactg cggcaagcac ggcaagacat gtggagggaa cccgcggtgg
    21421 cagcagcacc agtctggagt gtcgaccccc gtaccgggaa gcagcgcgag caggtcgcgg
    21481 tggaggccac ggcccagggg gtggacgagg cggtccgcgc cgcccacgcc gcgcgcggcg
    21541 ccctcgccga ccgcacggtc cgctcggcgt tcctgcgcac cgccgccgac cggctggagg
    21601 gcgcgaagga ccgcctcgtc gagctggcgg acgcggagac cgcgctcggc ccggtccggc
    21661 tcaccggtga actcgcccgc acctgctacc agctgcgggc cttcgcggac atcgtggacg
    21721 agggcgcgtt cctggacgtc gtcatcaacc accccgacga caccgcgacc ccgcccatcc
    21781 cggacctgcg ccgctacaag gtgcccctcg gtgtcgtggc cgtctactcg gcctccaact
    21841 tccccttcgc cttctccgtc gccggcggcg acaccgcgag cgcgctcgcg gccggctgcc
    21901 ccgtcgtcgt caaggcccac cccgaccacc ccgggctctc cgagcaggtc gcggccgagc
    21961 tgcgcgcggc cgccgccgag cacggcatcc ccgagggcgt cgtcggcctg gtccacggct
    22021 tcgaggccgg cgtcgagctg gtcaagcacc cgctggtcgc ggcggccggc ttcaccgggt
    22081 ccgtacgcgg cggccgcgcc ctcttcgacg cggcggcggc ccggccggtg ccgatcccgt
    22141 tccacggcga gctgggctcc ctgaaccccg tcgtcgtcac cgaggccgcg gccgccgagc
    22201 gcgccgaggc gatcggcgcc gggctcgcgg gctcgatgac gctgggcgtg ggccagttct
    22261 gcgtgaagcc gggcctggtg ctggcgcccg cgggcgaggc cggtgaccgg ctgctcaagt
    22321 cgttcacgga ggcggtcggc gaggtcgacg ccggcgtcct gctggaccac cgtatgcgcg
    22381 acaacttcat cgcgggcgtc gccgagcgcg ccgagctgcc gggcgtcgag gccccggtca
    22441 ccgccggcga gggcgacgag cacacggtcc gccccggctt cctcacggtc ccggcggaga
    22501 agctggccgt cgagggcggc gagcacgagc tgctgctgga ggagtgcttc ggccccctca
    22561 cggtcgtggc ccggtacgcg gacgacaccg aggcccaggc gctcctggcc cggctgcccg
    22621 gcaacctcac cgcgaccgtg cacctgtcgg aggaggaggc ggcgggcgag ggccgcggcg
    22681 cggagatcct cgcggaactc accccgctcg caggccgtgt cctcgtcaac ggctggccca
    22741 cgggcgtcgc cgtcgccccc gcccagcacc acggcggccc gtacccggcg acgacctcca
    22801 cgtccacctc cgtgggcggc acggccatcg agcgctggct gcgcccggtg gcgtaccagg
    22861 gcgccccgga ggccctgctg ccgccggagc tgcgcgacga caacccgctg gggctgccgc
    22921 ggcggttcaa cgggcggctc gagaggtaac gctccgccgg cccttcgggg caacgaagaa
    22981 ccccggttgc ttcgagcggc cggggttctt cgcgcgcgtg ccgcctactc cggcggtgta
    23041 ggcgtgtcgt gcgtgcggta catcgcctgg acgtccagct ccagctggac ggtggggccg
    23101 acgaccgcga tgccgcgggc cagcatcgag cggtagttga gcgtgaagtc ctcgcggtgc
    23161 agctccgcct tggcgagggc cgcgcagcgc agctcctgct cgtagccgcc gttcaccgtg
    23221 ccgaggtacg tcgtgtccag gttcaccgag cggctggtgc cgtgcatgct gagcgtgccc
    23281 tgcagcgtcc acttggagcc gccgcggtag acgaagcggg tgctcgtgaa gtcgatgaac
    23341 gggtaccgct cgacgtccag gaagtcggcg gaccgcaggt ggccgtcacg ggtgttgttg
    23401 cccgtggtga ggctcgacgc gtcgatgcgc gccgagaccc gtgagtcggc catgttctgc
    23461 gccacctgta tgccgccctc gaagcgggtg aagcggccgt ggacgtgggc catgccgacg
    23521 tgcttggcga tgaaccggat cgcggtgtgc ggcgggtcga acagccaggt gcccggtgcc
    23581 ggcagctcga gctggcgggc cggctcgagc gcgacgcgca gggtgggcgc ggacacaccg
    23641 gcgacgacct cgacgtcctg ccgggtgggc gtcaggccct cggcagcgat catcatgctg
    23701 taggtgccgg ggggcagcgt cgccatgaag aagccgaagg ggtcggtggt gccacgggtg
    23761 gcgacgcggt ggctgtccag cgcggtcacc gtgacctcgg cgccgcccat gggctggccc
    23821 atgggatcca cgacctcgca gccgatcgcg cccgcgccgg acggcagggg gaccgtgaga
    23881 cccgccgcgg caccggaacc gcttctggaa cgccggcgtc ggagcagtcc gaggaccatg
    23941 ctgttcacct ttcttcacat gtgtgggagt cgcgtgagaa ttcgctgaac aaatggtgtt
    24001 cgcggtcgcc aatggcaccc ggccaacggg tgcaggcaca taggggcggc tcattaacga
    24061 tcataaagca gctgtgaggg ggcgggtgtc tcaggatgag tcacctgtga ggacgatgcg
    24121 ggggaatacg gcactcccgg tgagagttgg caggaaccga gcggagggtg cctccgtctc
    24181 ctgtgatccg tacgacctgg agagagccgt agacatgcgc gtcgagatct ggagcgacat
    24241 cgcctgcccc tggtgctacg tgggcaaggc ccgcttcgag aaggcgctgg cggccttccc
    24301 gcaccgcgac caggtggagg tcgtccaccg ttccttcgag ctcgaccccg ggcgggccaa
    24361 gggcgatgtc gagccggtgc tgaagatgct gtccctgaag tacggcatga gcgaggcgca
    24421 ggcacgggcc ggcgaggaga acctgggcgc ccaggccgcc gccgagggcc tggcctaccg
    24481 caccgagggc cgtgaccacg gcaacacctt cgacatgcac cgtctgctgc acttcgccaa
    24541 ggcgcacggc cggcaggacg
//
