LOCUS       NZ_BMVW01000012        22253 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence12, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000012
VERSION     NZ_BMVW01000012.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 266917)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 223447
            Orig. end                         :: 245700
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22253
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22253
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22253
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12253](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12253
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(693..707)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            complement(1224..3161)
                     /locus_tag="IE242_RS26220"
                     /old_locus_tag="GCM10010365_53720"
     CDS             complement(1224..3161)
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (10-433). E-value:
                     4.1e-150. Score: 492.3. Matches aSDomain:
                     nrpspksdomains_IE242_RS26220_PKS_KS.1"
                     /NRPS_PKS="Domain: PP-binding (588-636). E-value: 4.5e-08.
                     Score: 25.3. Matches aSDomain:
                     nrpspksdomains_IE242_RS26220_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982687.1"
                     /locus_tag="IE242_RS26220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53720"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_229859458.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.2e-75, bitscore:
                     247.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 1.4e-149, bitscore:
                     492.3, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.9e-08, bitscore:
                     28.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKSDVDARSVAVIGMACRLPGASGADELWSLLRDGTDATSETPP
                     DRYDVDALYDSRPGPGRLASRRAGYVADVAGFDAEFFGMSAGEAVELDPQQRLLLMTAW
                     EALEDAGQRPDLLAGSRTGVFVGAARTDYLELTLRQGPQAATAAQLLNFRSLLSARLSH
                     FLDLRGPSIVVDTACSSSLTAVHQAVQSIRAGESPLALAAGVNLKLRPDEGLAMTAAGS
                     MSADGRSRFGDANADGHAPGDAVGVVVLKPLTAALADGDRIRAVIQGSAVGNDGGTSDS
                     VLNPSLTGQLEVLRWAYEDAGVDPAEVDYVEAHGSGSPALDMLELTALGEVLGRGRPAD
                     RPLLVGSVKTNVGHAEAAGGLTGLIKAVLCLEHGQVPPSLHLDTPSPRVDWHRLPVVVP
                     RALQDLPDRGRPAVVGISGQGSSALNAHVVLRQADPPTVRVKALKPRRPYVLPLSARTP
                     AALTALARRYAEYLGPGGAGAAYAVRDICFSAATRRQHHPYRTAVVGATHEELAAALTG
                     TLVGTGRASEAADRYRAGLDVDWDAEFKKGGTYVPLPLYAWQTERYWPGEERSDNDGDL
                     SAWVLSEHARTGFDDGSTLTEIGIDSLARLRIVVELTKRSGREIDPEEFGRLRTVGELR
                     AWTRTLGAAA"
     aSDomain        complement(1254..1397)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE242_RS26220_PP-binding.1"
                     /evalue="4.50E-08"
                     /label="IE242_RS26220_PP-binding.1"
                     /locus_tag="IE242_RS26220"
                     /protein_end="636"
                     /protein_start="588"
                     /score="25.3"
                     /tool="antismash"
                     /translation="FDDGSTLTEIGIDSLARLRIVVELTKRSGREIDPEEFGRLRTVGE
                     LRA"
     aSModule        complement(1254..3131)
                     /domains="nrpspksdomains_IE242_RS26220_PKS_KS.1"
                     /domains="nrpspksdomains_IE242_RS26220_PP-binding.1"
                     /incomplete
                     /locus_tags="IE242_RS26220"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(1863..3131)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE242_RS26220_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="4.10E-150"
                     /label="IE242_RS26220_PKS_KS.1"
                     /locus_tag="IE242_RS26220"
                     /protein_end="433"
                     /protein_start="10"
                     /score="492.3"
                     /tool="antismash"
                     /translation="VAVIGMACRLPGASGADELWSLLRDGTDATSETPPDRYDVDALYD
                     SRPGPGRLASRRAGYVADVAGFDAEFFGMSAGEAVELDPQQRLLLMTAWEALEDAGQRP
                     DLLAGSRTGVFVGAARTDYLELTLRQGPQAATAAQLLNFRSLLSARLSHFLDLRGPSIV
                     VDTACSSSLTAVHQAVQSIRAGESPLALAAGVNLKLRPDEGLAMTAAGSMSADGRSRFG
                     DANADGHAPGDAVGVVVLKPLTAALADGDRIRAVIQGSAVGNDGGTSDSVLNPSLTGQL
                     EVLRWAYEDAGVDPAEVDYVEAHGSGSPALDMLELTALGEVLGRGRPADRPLLVGSVKT
                     NVGHAEAAGGLTGLIKAVLCLEHGQVPPSLHLDTPSPRVDWHRLPVVVPRALQDLPDRG
                     RPAVVGISGQGSSALNAHVVLRQA"
     CDS_motif       complement(2082..2126)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE242_RS26220_0002"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="IE242_RS26220"
                     /protein_end="360"
                     /protein_start="345"
                     /score="11.3"
                     /tool="antismash"
                     /translation="GSVKTNVGHAEAAGG"
     CDS_motif       complement(2610..2657)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE242_RS26220_0001"
                     /evalue="6.70E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="IE242_RS26220"
                     /protein_end="184"
                     /protein_start="168"
                     /score="21.1"
                     /tool="antismash"
                     /translation="GPSIVVDTACSSSLTA"
     misc_feature    complement(3612..3627)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     misc_feature    3631..3644
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(3708..3723)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    complement(3814..3828)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            3823..4854
                     /locus_tag="IE242_RS26225"
                     /old_locus_tag="GCM10010365_53730"
     CDS             3823..4854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982686.1"
                     /locus_tag="IE242_RS26225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53730"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_189863410.1"
                     /transl_table=11
                     /translation="MDPLTTTDQARLEGEQRRLRLQILGLNNSEAEATFDRVARLAASF
                     TQTPLAMVNFINDERQMFRGMYVPTASPDDKADPDGGGIVFDLSSVAREVPNDYGFCPH
                     VVAQGSQLALDDVFDYPRFKGNPLVNDMGVRSYLGTPLRDNTGMILGTVCVADTKPRVW
                     DRKIREGMQELTETLLADFKLRDSLLAQQQELFAVFDGAPFPIMLTEGPNHLLRYANGK
                     QGAAFGMVPQFSPGRMALPGLESIGVFNAMDEAFHTGRAATLPRAQISTYDVPQPQEFS
                     FLCTPVRTSPGAPISGVLTVAMNITGQALIGAEQQAFAANVQERFERLGSGGVAAAFPG
                     QRV"
     gene            complement(4930..6183)
                     /locus_tag="IE242_RS26230"
                     /old_locus_tag="GCM10010365_53740"
     CDS             complement(4930..6183)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999861.1"
                     /locus_tag="IE242_RS26230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53740"
                     /product="cytochrome P450"
                     /protein_id="WP_189863412.1"
                     /sec_met_domain="p450 (E-value: 3.9e-11, bitscore: 35.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPAAEPSPLTIDATGRDIHGEAARIRARGPATRVELPGRVEAWA
                     VSSPELLKRLLTDPRVSKDPRQHWTRFREGGITPDWPLFTWVAVQNMFTAYGGEHRRLR
                     TLISVAFTARRTAALRPRITELTGELLDRVAETARRSGSVDLREEFCYPLPIQVIGELF
                     GVPGHLAPELRRLVDGLFHTAADPGEMNATYERMYGVLTELVAAKRTSPGDDLTSALIA
                     ARDERGDTRLSEDELLNTLVLFISAGHETTVNLLDNAIHALLTHPEQLTHVRAGRASWD
                     DVVEETLRRDAPVASLPLRYAVEDLPLGELGGPEGVVIGKGEAILAAYAAAGRDPRRHG
                     EDAALFDVTRADKEHLAFGYGVHRCLGAPLGRLEAVIALPALFERFPGLRLAAHGDDLG
                     HVESFISNGHRRLPVRLG"
     gene            6585..>8033
                     /locus_tag="IE242_RS26235"
                     /old_locus_tag="GCM10010365_53750"
                     /pseudo=""
     CDS             6585..>8033
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481968.1"
                     /locus_tag="IE242_RS26235"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53750"
                     /product="S8 family peptidase"
                     /pseudo=""
                     /sec_met_domain="Peptidase_S8 (E-value: 2.1e-53, bitscore:
                     175.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTSPSRAAGRKLISVAAVSAVSAALLAGATTTAAAAQAPTPAPA
                     LAGPAEAAPSVPAERLIVGYEKGAAEAASDKAASADAETKGRKAGEDLGFERRLGSGAA
                     LVGLGDGLTEQDVTDVIAEYRADPQVAYVVPDRLNTPQATPNDTHYTKQWDLFEATAGM
                     RVPGAWDLSTGSGVTVAVIDTGYVAHSDLAANIVPGYDFISDTFVSADGNGRDSNPADP
                     GDWSSAGECGTGVPASGSSWHGTHVAGTIAAATNNGKGVAGVAYGAKVSPLRVLGKCGG
                     YDSDIIDAITWASGGSVAGVPANTNVAKVINMSLGGSGSCTTATQSAINAAVNRGTTVV
                     VAAGNSNANAANFSPASCSNVITVAATNRSGARASYSNYGSVVDIAAPGGQTSTGSANG
                     ILSTLNSGTKTPSTENYAYYQGTSMAAPHIAGLVALMKSAKPTLTPAQIEAAVKANARA
                     LPGTCSGGCGAGLADAAKTVQAVRG"
     gene            8099..8674
                     /locus_tag="IE242_RS26240"
                     /old_locus_tag="GCM10010365_53760"
     CDS             8099..8674
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983607.1"
                     /locus_tag="IE242_RS26240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53760"
                     /product="hypothetical protein"
                     /protein_id="WP_189863414.1"
                     /transl_table=11
                     /translation="MESEVAPGAWGTTCPGCGGSAVRTVPDTCADQESVRSRLSDRLAR
                     QPGVTSRFDTFTHTVEGLLLTAVGGALAYEGIQKDKQLYTIGGSVLAVLLFLGTIYVIF
                     DEIRERRVVAAGESRADALWRSASCCSGCGAVFFPAGSPWPHPLTPEQFQKYVWTEAGY
                     GKRLDKRVRDVALPPAHPSRPGGVSDHA"
     gene            8667..9836
                     /locus_tag="IE242_RS26245"
                     /old_locus_tag="GCM10010365_53770"
     CDS             8667..9836
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071439.1"
                     /locus_tag="IE242_RS26245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53770"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_189863416.1"
                     /transl_table=11
                     /translation="MPDTADVPEAPVITSSDPESFPHSVLAERHPALIRRVRDAFPYGP
                     AQHRALDALLKSATEGVIEALDGDAWWEAWGVDEYAGRTWFEVPFLWSESYFYRRLLHA
                     VGHFGSRPWSAPWQGVDPFRPFKLAELAGPEAREEISALDRLAALPLEEQRTALLHGSL
                     WGNRADLGFRIQKDDDEASAAELVADDSDALWQLLTGAGTLVLVADNAGRELVPDLLLV
                     DHLLSHGHIERAVLHVKPYPYYVSDATTADVVDAVRHLTDAGTDHGRRLWSAMADGRID
                     LRAHPFSCGPLPYADMPDDLRAEFAAADVTVLKGDLNYRRLVGDRMWPPTTPFADVTAY
                     FPGPVAALRTLKSDVITGLAPETEARLVAAEGQWRWRTSGTHALIQVRS"
     gene            10001..12253
                     /gene="cyc2"
                     /locus_tag="IE242_RS26250"
                     /old_locus_tag="GCM10010365_53780"
     CDS             10001..12253
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999852.1"
                     /locus_tag="IE242_RS26250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53780"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_189863417.1"
                     /sec_met_domain="T1TS (E-value: 6.7e-82, bitscore: 269.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFRLPHFYLPYPARLNPHLDEARAHSVGWARGMGMLEGSGVW
                     EQADLDAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLEKYKRTKDRAGGKAH
                     LDRLPLFMPLDLATPVPEPENPVEAGLADLWARTVPAMSEDWRARFAVATEHLLNESLW
                     ELSNIGEGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPARVAGTRPLRVLTETFAD
                     AVHLRNDLFSYQREVEDEGELSNGVLVLETFFGCTTQEAADTVNDILTSRLHQFEHTAL
                     TEVPALALERGLTPGETAAVAAYTKGLQDWQSGGHEWHMRSSRYMNEGAASARGPLDLG
                     GAVLSGPVPLFRAGLGRRGADVGALLAGAAAMGAPPTPFGQWGRLRAHTHVPFQKVGPS
                     LLPPFHMPFEVRLNPELDGARQRLLPWARRMGILAEGVWDEDRLDAADLPLCAAGLDPD
                     GTPEALDLGSRWLTWGTYGDDYYPLVFGRRRDLAAARLCTERLSACMPVGEAEQPLLPA
                     NAMERGLTDLWRRTTAGMTREARRTVRASVEVMTRAWLWELSNQLQHRVPDPVDYLEMR
                     RATFGSDLTMSLCRAGHGPAVPPEVYRSGPVRSLENAAADYAMLVNDVFSYQKEIEYEG
                     EIHNGVLVVQTFFGCGYPAALGVVHDLMTQRMRQFQHVTQHELPVLCADFGLSPQARSV
                     LDGYVDQLRNWMAGILNWHREVRRYRPEHLARRTHGFLPDRAPAPLSAGLPEPVTL"
     gene            12370..14250
                     /gene="phsA"
                     /locus_tag="IE242_RS26255"
                     /old_locus_tag="GCM10010365_53790"
     CDS             12370..14250
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431964.1"
                     /locus_tag="IE242_RS26255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53790"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_189863499.1"
                     /transl_table=11
                     /translation="MIERAADRTTGDRAPAAGELAPYVAPLPVPPLLRPATGDVPHATE
                     IAVRPTWVRLHPQLPPTLMWGYDGQVPGPTIEVRRGQRVRIAWTNRVPRTAPFPVTAAE
                     VPRRAQGTPPATTEPGRGGAVPNQDVAALPAWLVTHVHGAQTGGGNDGWTDNAVGSGDA
                     QLAEYPNDHQAVHWWYHDHAMNITRWNVYAGLYGTYLVRDDEEEALRLPRGKREIPLLL
                     ADRNLDTDEDGRLNGRLLHKTVVVEERNPETGKPVTLPFTGPYTTVNGRIWPYADVDDA
                     WYRFRLVNASNARVYRLVLIDEDDNPVPGVVHQIGSDGGLLPRPVPIDFTGDLPVLSAA
                     PAERFDLLVDFRRLAGRRLRLVDKGPGQAPGVPDAVNDVRYPQVMEFRVHESCERDTFE
                     LPEVLSGSFRRLTHDTPHGHRLIVLTPPGTKGGGGHPEIWEMTEVHDPVGIQVPADGVI
                     QVTGEDGTTKTYRRTARTFNDGLGFTIAEGSHEQWSFLNLAPVLHPMHIHLADFQLLGR
                     DAYDVSGFDRAIGGTVTPVRFDPETRIPVAPNERGNKDVFQVPGSQTVRLMGRFDGAYG
                     RFMYHCHLLEHEDMGMMRPFVVLPAEVLKFDHGAGHGGHDGHGGHDGRTS"
     gene            14368..15492
                     /locus_tag="IE242_RS26260"
                     /old_locus_tag="GCM10010365_53800"
     CDS             14368..15492
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481973.1"
                     /locus_tag="IE242_RS26260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53800"
                     /product="Xaa-Pro peptidase family protein"
                     /protein_id="WP_189863419.1"
                     /transl_table=11
                     /translation="MTDTPAPFTAADHAARLRRAESAAADAGLDGILVAPGPDLVWLTG
                     YRPVETERLTLLVLRPGEEPVLVVPKLEAPDAARAAPALALRDWTDGQDPYRAAASLLG
                     GTGGTGRYAVSDNAWAMHLLGLQRRLPDTSYVSLTDALPMLRAVKDPVELDRLAAAGAA
                     ADAAYEEIRTVRFAGRRETEVAADLAGLLRRFGHSQVDFTIVASGPNGADPHHEAGERT
                     IERGDMVVLDFGGLKDGYGSDTSRTVHVGEPDAEERRVHDIVRAAQEEGFRAVRPGAAC
                     QDVDRAARAVIDEAGYGAYFVHRTGHGIGVTTHEPPYMVEGEERPLVPGMCFSVEPGIY
                     LPGRFGVRIEDIVTVTEDGGRRLNTTSRELAIVD"
     gene            15612..16523
                     /locus_tag="IE242_RS26265"
                     /old_locus_tag="GCM10010365_53810"
     CDS             15612..16523
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481974.1"
                     /locus_tag="IE242_RS26265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53810"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_189863421.1"
                     /sec_met_domain="APH (E-value: 2.8e-16, bitscore: 53.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLRDSDGPDVQPVAEDGRHCTWWVGTR
                     HVLRLAPDREASVRLRRELRLRDLVRPHLPVAVPANVAHGDWAPGLAYALDARLTGGTA
                     EEHAVSALGEADLAGLLTGLREVPVRQAEALGVPRTAPRSLETLRTAGAKAAGHLEEAD
                     EFAAGRFGRFTPLAADRLTGSAPVLVHHGLEGRHLLVSGDGRVRGVLGWSGAALGDPAE
                     DIAGLALAVGSPAAVRAATLAGYGARPCLRGLWLARCDAVVRLSDRLRDRGDDPLALLR
                     GRLRRAWEPILLERVTELPGEE"
     gene            complement(16603..18348)
                     /gene="treZ"
                     /locus_tag="IE242_RS26270"
                     /old_locus_tag="GCM10010365_53820"
     CDS             complement(16603..18348)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125304.1"
                     /locus_tag="IE242_RS26270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53820"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_189863423.1"
                     /sec_met_domain="Alpha-amylase (E-value: 5.2e-13, bitscore:
                     42.9, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPLADRVTLHCADVTRALERDTRRSGWWTGEAEATDGTR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHERYAWRVPWAGRGLPGAVLYELHVGTY
                     TREGTLDAAAERLGHLVDLGVTHVELMPLCPFPGTHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHEVGLGVVLDVVHNHLGPSGNYLPAFGPYFTDRHHTPWGVAVNLDAPGSDEVR
                     AYFAGSALAWLRDYRLDGLRLDAVHALRDTRACHFLEELSSAVDALAEEVERPLFLIAE
                     SDLNDPRLITRRAQGGYGLHAQWNDDFHHALHTALTGESQGYYEDFARDPFAALAKTFT
                     GGYFHDGTYSTFRGRGHGRPLDRTRVSAHRLLGYTQTHDQIGNRAQGDRLSASLSPGLL
                     ACGAALTLTSPFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRRGRRREFAEHGWAEE
                     EIPDPQDPATRERSCLDWSEPTREPHARVLAWYRKLIALRRTQPDLSDPDLAEVRAAHD
                     GQARWFAFRRGDIRVAVNLGREPAAIPLGVHRARVLAAWEPVAAPGPDGVLRLPGESCV
                     VLTQE"
     gene            18518..19069
                     /locus_tag="IE242_RS26275"
                     /old_locus_tag="GCM10010365_53830"
     CDS             18518..19069
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010350955.1"
                     /locus_tag="IE242_RS26275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53830"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_189863425.1"
                     /transl_table=11
                     /translation="MTSSFEFHTYPARLSDAERDRALKALREGVALGRLSHDTFVRRME
                     LALSARRADELAALTADLPTESRLSRLVFGTVEAVSGFTVRLRRAWRAERLPKLLLPQA
                     GGGHPLRIGRDPVNGLRLSHETVSRVHAELSRQGGLWVLRDLGSTNGTTVNGRRVIGAA
                     VVRAGDQVGFGRMAFRLASE"
     gene            19234..20577
                     /locus_tag="IE242_RS26280"
                     /old_locus_tag="GCM10010365_53840"
     CDS             19234..20577
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062765.1"
                     /locus_tag="IE242_RS26280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53840"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_189863427.1"
                     /transl_table=11
                     /translation="MDELAVRAAALVARHPREARLRRVGTSREGTPLWLLSVGHGGRHV
                     LVVAGPHANEPVGGATALRLAERVLADRRLREGTDTTWNLLLCLDPDGAHRNEGWLAGP
                     YTLGHYFRNFFRPGFLEQPEWLPEGAGGDVLPETRALLDLQDELRPFLQCSLHGVDIGG
                     GFVELTRDLPGLPERLARIAARLGVPRELGPYDTLYWPTLGPAVYRVPPPRPGDLAAAI
                     TEAAVESTWFHPHRYGTVTAIVEAPMWGVRAVEDASEPEDADALLRAVSRTLRHDTALL
                     EDVLARVRPSVSTGPDAARLLAPVDDYLLVGPGVADSWDPGAHRGAGGRPLPPLDTARL
                     TALAISARRVALRTAGLLHQLVRRSGQDPAGVLPRLDRLIDAWCADYRDGHGARWIPPG
                     RQVEYQSRVVLAAFRLSGRPHAREDPDPGSPPGEPGLGVQRAVPMRRE"
     gene            complement(20654..21904)
                     /locus_tag="IE242_RS26285"
                     /old_locus_tag="GCM10010365_53850"
     CDS             complement(20654..21904)
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657035.1"
                     /locus_tag="IE242_RS26285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_53850"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_189863429.1"
                     /transl_table=11
                     /translation="MSLLRELRYPTVTELESSARALAARRPALCAFRQIGVSRAGRPLQ
                     LLSVGHAPRAVLVVAGAHANEPTGGSTLLAVAERVLDERELRTGTSWHFLLCADPDGAS
                     LHVTPAPRTLFDYHLGFFRPAGPEQPEWSPSVLPPDRLPPETRALTRVIDELRPYLQVT
                     LHGTDLGGSWVQLTKDVPGLAEPFAKSAAELNIPVETSASDAAGWRASGPGVRVMPDLG
                     PDTAHPRVPDDARHSTWYRAHRHGGLTAVVEVPMWASDLVDDPAPHPAPEAALGELARR
                     LRRDACQVERILTEALPRLPGAEGPLLRATRWALDLVPGLAADWARGTPPDTTVAYLGS
                     VEAFGRRLPLRAAAMLLRVLREADDRAAPRLEDLVATWSGSFAERFRARWVPLENQVEH
                     QARTVVTAALHARDHVT"
ORIGIN
        1 gtaccagtgc ttctcggtcg gccgccccgg gccgtcgagg ccgacgaagc ggccggggtt
       61 gttcgccggg tcgagatagc cggggaagcg ctgcgggccg cgcatgcaca gctcgccgct
      121 gtcggacggc cggccgtcct cgcccagcag cacgaagtcc agcgtggggt ggcagcggcc
      181 gatgggggcg gtgccgttcg gggtcgtggg ccagtcggcg gggtcggccg ggaagcggta
      241 gcccgtgcag gagatggtca gctcggtcgg gccgtacagc acctccagac cgctctgcgg
      301 cgcggcccgg tgccactcgc gggccgcgtc cagggtgagc ggttccccgc cgaagacgct
      361 ccaccgcagc gtcggcatgc tgccgggctt cagtgtgccg agccgggagg cgaaggtgat
      421 gagcgacggc accgagaacc agtgggtgag ccgcagcgag ttgatcgtct tcacggggga
      481 cagcagctgg ctgcgggcgg gcacgaccag cgtcccgccg cccgcccagg cgacgaacag
      541 gtcgtgcacc gaggcgtcga aggtgagctc gaaggtctgg gagaggcggc tgccgggccc
      601 gatgccgtac cggggggcga ggtggccgat gttggcgcag acgttccggt gggtgatcgg
      661 gacgcccttc ggtgcgcccg tggagccgga ggtgaagatg atgtacgcga ggtcgtcggg
      721 ggtggcccgg gggtggtccg ggtcggggtg cgggccggcg gggagggcgg ccagctcgtc
      781 ggaggcgagg acgagctgag ggaccgtcag accggtggcc ggtgcgtcgg cgaggaccag
      841 gtccagggcc gccgccccgg cgatgtccgc ggtccgcccg gccgggtgct ccgggttgag
      901 cgggacgacg gtcgccccgg cccgcaggat cgccaggtat cccgcgtacg cgagcaccga
      961 ccggctcgcc agcagcccga tccgccgtgg cgggaccccg gccccggacg cggccagccg
     1021 ggccgcgatc cgctccgcga ggtcccgcag ccgggcgtag gtgtagctct cctcgccgat
     1081 ctccagggcc acggccgtgt ccccgagctc gtcggcggag cgggcgaacc aggcgtacag
     1141 ggtgccgggg aggcccgtgg ccgccgggcc gagcggcttt ccggggacgc cgtccccgcc
     1201 gtcgtgcggc tgcgtcacgc tgctcacgcc gcggccccca gcgtcctcgt ccacgcgcgc
     1261 agttcgccca ccgtgcgcag ccggccgaac tcctcggggt ctatctcccg gccggaacgt
     1321 ttcgtcagct cgacgacgat gcgcagcctg gcgagcgagt cgatgcctat ctcggtgagc
     1381 gtggagccgt cgtcgaagcc ggtgcgggcg tgctcgctca gaacccaggc ggacaggtcg
     1441 ccatcgttgt cggagcgctc ctcgccgggc cagtaccgct cggtctgcca ggcgtacagc
     1501 gggagcggca cataggtgcc gcccttcttg aactccgcgt cccagtccac gtccaggccc
     1561 gcgcggtagc ggtcggcggc ctccgaggcg cgccccgtgc cgacgagcgt gccggtgagc
     1621 gccgcggcca gctcctcgtg ggtggccccg acgacggccg tccggtacgg gtggtgctgc
     1681 cggcgggtgg ccgcgctgaa gcagatgtcc cgcaccgcgt acgccgcgcc ggccccgccc
     1741 gggcccaggt actcggcgta tctgcgggcc agggcggtga gggcggcggg ggtgcgggcg
     1801 gacagcggga gcacatacgg cctgcggggc ttgagcgcct tgacgcggac cgtcggcgga
     1861 tcggcctggc gcagcaccac atgcgcgttg agcgcggagg agccctgccc ggagatgccg
     1921 acgacggccg gccggccccg gtcggggagg tcctggagcg cgcgcgggac cacgaccggc
     1981 agccggtgcc agtcgacccg cgggctcggg gtgtccaggt gcaggctggg cggcacctgg
     2041 ccgtgctcca ggcacagcac cgccttgatc agcccggtca gaccgccggc ggcctcggcg
     2101 tgaccgacgt tggtcttcac ggagcccacc agcagtggcc ggtcggcggg ccgtccccgg
     2161 cccaggacct cgccgagcgc ggtgagttcc agcatgtcga gggcggggga cccggagccg
     2221 tgcgcctcca cgtagtccac ctcggcgggg tcgacgccgg cgtcctcgta cgcccagcgc
     2281 agcacctcga gctggccggt gagggagggg ttgaggaccg agtcgctggt gccgccgtcg
     2341 ttgccgacgg cgctgccctg gatgacggcg cggatgcggt cgccgtcggc gagggcggcg
     2401 gtgaggggct tcagcaccac gacgccgacc gcgtcgccgg gcgcgtgccc gtcggcgttc
     2461 gcgtcgccga atctgctgcg gccgtcggcg gacatggagc cggccgcggt catcgccagg
     2521 ccctcgtccg ggcgcagctt gaggttcacg ccggcggcca gggcgagggg gctctccccg
     2581 gcgcggatgc tctgcaccgc ctggtgcacg gcggtcagcg acgacgagca cgccgtgtcc
     2641 acgacaatgc tgggtccgcg gaggtcgagg aagtgcgaca gccgggcgga gagcagcgag
     2701 cggaagttca gcagctgggc cgccgtcgcc gcctgtggtc cctggcgcag cgtcagctcc
     2761 aggtagtccg tgcgggcggc gcccacgaag accccggtgc ggctgcccgc gagcaggtcg
     2821 ggccgctggc cggcgtcctc cagcgcctcc caggccgtca tcagcagcag ccgctgctgc
     2881 gggtcgagtt cgacggcctc tccggcggac atgccgaaga actcggcgtc gaagccggcg
     2941 acgtcggcga cgtacccggc gcgccggctc gcgagcctgc cgggccccgg acgggagtcg
     3001 tacagggcgt cgacgtcata acggtcggga ggggtctcgc tggtggcgtc ggtcccgtcc
     3061 cgcagcaggg accacagttc atcggctccg gatgcgcccg gcagccggca ggccataccg
     3121 atcaccgcga ccgaccgtgc gtccacgtcc gacttcttca acgcaactct ccttcgctgc
     3181 ttcgtcgatg tgcgtgtgag atggcgcgct tgacgtccgc ccgtcatcgc ggttgccaac
     3241 ggggcgggtg ggaacagggt tacgagtgtg aggtgaatcc ccggacgccg tcgtaccggg
     3301 gtggtgactg ctcggccgag catggtgccc gcagctgccc gaagcggcgg ccgaccgctc
     3361 ccggtgccgc gtcgcggcgc tgtgcgcaat gtggatcttg gcgtgaaatc ggccggtgcg
     3421 ccagagtgtt ccggaccaca cggcgacggg atgcccgcag ctcgtaccgc acttcgccca
     3481 ccggcccagg accttcctca caggcgcgcc gtacacgcag tcgtcgaaaa ccagcccccg
     3541 gacgattgtc gtacccaaaa tcggatccgc tcgttttcgg atcaaggaat ggcgaaaagt
     3601 gatcgccccg ggttgaaacc tgtagatatt tggacagact ccgagaccgg gctggtgtga
     3661 gggatgtgac gagatgtgag aggagaggcg gtcgcctggg gctttgtggg accactgggt
     3721 caagagtgcc cagccgtcgc ggagttgaga tcgtgcggaa cgagacggga ttcgacgggt
     3781 ggggtgaacc gcggagtccg attctctgct ttcatcgacc tcatggatcc cctgacgacc
     3841 accgaccagg cgcgcctcga gggtgagcag cgcaggctgc gactgcagat tctcggcctc
     3901 aacaactccg aggcggaagc cacgttcgac cgcgtcgccc gtctcgcggc cagcttcacc
     3961 cagaccccgc tggccatggt caacttcatc aacgacgagc gccagatgtt ccgcggcatg
     4021 tacgtgccca ccgcgtcgcc cgacgacaag gccgaccccg acggcggcgg catcgtcttc
     4081 gacctcagca gcgtcgcccg tgaggtgccc aacgactacg gcttctgccc ccacgtggtg
     4141 gcccaggggt cccagctcgc cctggacgac gtcttcgact acccgcgctt caagggcaac
     4201 ccgctggtca acgacatggg cgtgcgctcg tacctgggca ccccgctgcg cgacaacacc
     4261 ggcatgatcc tcggcaccgt gtgcgtcgcc gacaccaagc cccgggtctg ggaccgcaag
     4321 atccgcgagg gcatgcagga gctcaccgag accctgctcg cggacttcaa gctgcgcgac
     4381 agcctgctcg cccagcagca ggagctgttc gcggtgttcg acggcgcgcc gttccccatc
     4441 atgctcaccg agggcccgaa ccacctgctg cgctacgcca acggcaagca gggcgccgcg
     4501 ttcggcatgg tgccgcagtt cagcccgggc cggatggcgc tgcccggcct ggagtccatc
     4561 ggcgtcttca acgcgatgga cgaggccttc cacaccggcc gcgcggccac gctgccccgg
     4621 gcgcagatca gcacgtacga cgtcccgcag ccgcaggagt tcagcttcct gtgcaccccg
     4681 gtgcgcacct cgccgggcgc gcccatcagc ggggtcctca ccgtggccat gaacatcacg
     4741 ggacaggccc tcatcggcgc cgagcagcag gcgttcgccg cgaacgtcca ggagcgcttc
     4801 gagcgtctcg gctcgggcgg tgtcgcggcg gcgttcccgg gccagcgggt gtaggagcgg
     4861 cgccgcggcc ggccggcggg gcggaggcat gggggtcctc ccgcctcccg gccggccgcc
     4921 gcgaggtgat cagccgaggc gtacgggcag ccgccggtga ccgttggaga tgaacgactc
     4981 cacatgtccc aggtcgtcgc cgtgcgcggc caggcggagg ccggggaacc gttcgaacag
     5041 ggccggcagg gcgatcaccg cctccaggcg gccgagcggc gcgcccaggc agcggtgcac
     5101 gccgtacccg aaggccaggt gctccttgtc ggcgcgggtg acgtcgaaga gggcggcgtc
     5161 ctcgccgtgc cgccgcggat cgcgcccggc ggcggcgtac gcggcgagga tcgcctcgcc
     5221 cttgccgatc accacgccct ccggaccgcc gagctcaccg agcggaaggt cctcgacggc
     5281 gtaccgcagc ggcaggctgg cgaccggggc gtcccgccgc agggtctcct cgaccacgtc
     5341 gtcccacgag gcgcggcccg cccgtacgtg ggtcagctgt tccgggtggg tgagcagggc
     5401 gtggatcgcg ttgtccagga ggttgacggt ggtctcgtgg ccggcgctga tgaacagcac
     5461 cagggtgttg agcagctcgt cctcgctgag ccgggtgtcc ccccgctcgt cgcgggcggc
     5521 gatcagcgcg ctggtcaggt cgtcgccggg ggacgtgcgc ttcgcggcga cgagttcggt
     5581 gaggacgccg tacatccgct cgtacgtggc gttcatctcg cccgggtcgg cggccgtgtg
     5641 gaacaggccg tccaccaggc gccgcagctc gggcgcgagg tgcccgggca cgccgaacag
     5701 ctcgccgatc acctggatcg gcagcggata gcagaactcc tcgcgcagat ccacgctccc
     5761 ggaacggcgc gcggtctccg ccacccggtc caggagttca ccggtcagct ccgttatccg
     5821 gggccgcagc gcggccgtgc ggcgggcggt gaacgccacg gagatcaggg tgcgcagacg
     5881 ccggtgctcg ccgccgtacg cggtgaacat gttctgcacg gcgacccagg tgaacagcgg
     5941 ccagtcgggg gtgatgccgc cctcccggaa ccgcgtccag tgctgccggg ggtccttcga
     6001 caccctgggg tccgtgagca gccgcttgag cagctcggga ctgctgaccg cccacgcctc
     6061 gacccggccc gggagctcga cgcgggtcgc cggtcctctc gcgcggatcc gggcggcctc
     6121 gccgtggatg tcacggccgg tcgcgtcgat cgtcagcggg ctgggttccg cggctggtcc
     6181 catcgggcct cctcgtactc gaactcgaag tactcacggc cgatcacgct gcggtgcggt
     6241 ggtgccatcc ggcggcctcg cggggcacgc gctgcgtgtg gggaacttac cgtgccagta
     6301 gcggcacgtc gatgcctcac gcatccaccg ggcaccgagt gactgtgggg catccagggg
     6361 acttcccccc tccgcatcga gggttttccc tgtatccgcg caggccggac ggcacctatc
     6421 gttccctcca cagcgaaccc acaggcaacc ccgaacgggt cgctcgcgca ccaggccggc
     6481 cccacgcgcc ccacctttct tcgtaccccc cgccgcttcg atgccgaagc gattcaccgc
     6541 cgctccgcgc cgtccgcgcc gagccggcca ggaaaggcaa gcccttgcgc acctccccct
     6601 cccgtgccgc gggacggaag ctgatatccg tcgccgccgt ctccgctgtc tccgccgccc
     6661 tgctggccgg cgcgaccacc acggccgccg ccgcccaggc ccccaccccg gcccccgccc
     6721 tcgccggtcc ggccgaggcc gccccctccg tccccgccga gcgtctgatc gtcggctacg
     6781 agaagggcgc cgccgaggcc gcctcggaca aggctgcctc cgccgacgcc gagaccaagg
     6841 gccgcaaggc cggcgaggac ctcggtttcg agcgccgcct cggcagcggc gccgccctcg
     6901 tcggcctggg cgacggcctc accgagcagg acgtcaccga cgtcatcgcc gagtaccggg
     6961 ccgacccgca ggtcgcctac gtcgtaccgg accgcctcaa cacaccgcag gccaccccga
     7021 acgacacgca ctacaccaag cagtgggacc tgttcgaggc caccgcgggc atgcgcgtgc
     7081 ccggcgcctg ggacctctcc accggcagcg gggtgaccgt cgccgtcatc gacaccggct
     7141 acgtcgccca ctccgacctc gccgcgaaca tcgtccccgg ctacgacttc atctccgaca
     7201 ccttcgtctc cgcagacggc aacgggcgcg acagcaaccc ggccgacccg ggcgactggt
     7261 ccagcgcggg cgagtgcggc accggcgtcc ccgcgagcgg ctcgtcctgg cacggcacgc
     7321 acgtcgcggg caccatcgcc gcggccacga acaacggcaa gggcgtcgcg ggcgtcgcgt
     7381 acggcgcgaa ggtctccccg ctgcgcgtcc tcggcaagtg cggcggctac gactccgaca
     7441 tcatcgacgc catcacctgg gcgtccggcg gcagcgtcgc cggtgtcccg gccaacacca
     7501 acgtcgccaa ggtcatcaac atgagcctgg gcggctccgg ttcgtgcacg acggccacgc
     7561 agagcgccat caacgcggcc gtgaaccgcg gcaccaccgt cgtcgtcgcc gcgggcaaca
     7621 gcaacgccaa cgccgcgaac ttctccccgg cgagctgctc caacgtcatc acggtcgccg
     7681 cgaccaaccg cagcggcgcc cgcgcctcgt actcgaacta cggctcggtc gtcgacatcg
     7741 ccgctcccgg cggccagacc agcacgggct cggccaacgg catcctgtcc acgctgaact
     7801 ccggcacgaa gaccccctcg accgagaact acgcgtacta ccagggcacc agcatggccg
     7861 ccccgcacat cgcgggcctg gtcgcgctga tgaagtcggc gaagcccacg ctgaccccgg
     7921 cccagatcga ggcggcggtc aaggcgaacg cccgcgccct gcccggcacc tgctcgggcg
     7981 gctgcggcgc cggcctcgcg gacgccgcga agaccgtgca ggcggtgcgc ggctagtccg
     8041 cccgcgacga acggccggcc ggtgcgagcg cgcaccggcc ggccgttagc gtaggcgcat
     8101 ggagagcgaa gtggccccgg gggcctgggg aacgacctgt cccggctgtg gtggatccgc
     8161 ggtgcgtacc gtgccggaca cctgcgccga ccaggagtcc gtacgcagcc gcctgtccga
     8221 ccggctggcg agacaaccgg gcgtcacctc ccggttcgac accttcacgc acaccgtcga
     8281 ggggctgctg ctgaccgccg tgggcggcgc cctcgcctat gagggcatcc agaaggacaa
     8341 gcagctctac acgatcggcg gctcggtgct ggcggtgctg ctgttcctcg gcacgatcta
     8401 cgtcatcttc gacgagatcc gtgagcggcg cgtggtcgcg gcgggggagt cacgcgccga
     8461 cgcgctgtgg cgctcggcct cctgctgctc cgggtgcggg gcggtgttct tcccggccgg
     8521 ttcgccctgg ccccacccgc tgacgcccga gcagttccag aagtacgtgt ggaccgaggc
     8581 cggttacggc aagcggctcg acaagcgggt cagggacgtg gccctgcctc ccgcccaccc
     8641 ctcccggccg ggtggagtat cggaccatgc ctgacaccgc cgacgtgccc gaagcccccg
     8701 tgatcaccag ctccgacccg gaatccttcc cgcacagtgt gctggccgaa cgccaccccg
     8761 cgctcatccg cagggtgcgc gacgccttcc cgtacggccc cgcacagcac cgcgcgctgg
     8821 acgcgctgct gaagagcgcc accgagggcg tgatcgaggc cctggacggc gacgcctggt
     8881 gggaggcgtg gggcgtggac gagtacgccg gccgcacctg gttcgaggtg cccttcctct
     8941 ggtccgagag ctacttctac cgccggctcc tgcacgccgt cggtcacttc ggatcccgcc
     9001 cgtggtccgc cccgtggcag ggcgtcgacc cgttccgccc cttcaagctc gccgagctcg
     9061 ccggtccgga ggcccgggag gagatctccg ccctggaccg gctcgccgcc ctgcccctcg
     9121 aggagcagcg cacggccctg ctccacggct cgctctgggg caaccgcgcc gacctgggct
     9181 tccgcatcca gaaggacgac gacgaggcga gcgccgccga actcgtcgcg gacgacagcg
     9241 acgcgctgtg gcagttgctc accggggccg ggacgctggt cctcgtcgcc gacaacgcgg
     9301 gccgcgaact cgtccccgac ctcctgctcg tcgaccacct cctgagccac ggccacatcg
     9361 aacgggccgt gctgcacgtg aagccgtacc cctactacgt ctccgacgcc acgacggccg
     9421 acgtcgtcga cgccgtacgc cacctgaccg acgccggtac ggaccacggc cggcgcctgt
     9481 ggtccgcgat ggccgacggc cggatcgacc tgcgcgccca ccccttctcc tgcggcccgc
     9541 tgccgtacgc ggacatgccg gacgacctcc gcgcggagtt cgcggccgcg gacgtcaccg
     9601 tcctgaaggg cgatctcaac taccgccggc tggtgggcga ccgcatgtgg ccgccgacca
     9661 caccgttcgc ggacgtcacg gcgtacttcc ccggcccggt cgccgcgctg cgcaccctca
     9721 agtcggacgt gatcaccggt ctcgccccgg aaacggaggc ccgtctcgtc gcggcggagg
     9781 gacagtggcg ctggcggacg agcggaacgc atgcgctgat ccaggtccgg tcgtagcggg
     9841 ggcgggggcg ggggcggggg tgcgggagcg gcaagggcgg agccgcgcgg gcgccggtac
     9901 ggcgtgacgg ggagttccgc caccgccccc gattcacgcg atggtgtgac catgtcccgc
     9961 cgcccggatg cgcccggaag gactcgggta gggcccggcc atgacacagc cgttccgcct
    10021 cccgcacttc tacctgccgt accccgcacg gctgaacccg catctggacg aggcccgcgc
    10081 ccactccgtc ggctgggcgc gcggcatggg catgctggag ggttccggcg tctgggagca
    10141 ggcggacctc gacgcgcacg actacgggct gctgtgcgcg tacacgcacc ccgactgcga
    10201 cggcccggcg ctctcgctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggag aagtacaagc gcaccaagga ccgcgccggc ggcaaggccc acctcgaccg
    10321 gctgccgctg ttcatgccgc tcgacctcgc cacccccgta ccggagccgg agaaccccgt
    10381 cgaggcgggt ctcgccgatc tgtgggcgcg cacggtcccg gcgatgtcgg aggactggcg
    10441 cgcccggttc gcggtcgcca ccgagcacct gctgaacgag tcgctgtggg agctgtccaa
    10501 catcggcgag gggcggatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgccccc tggtcggcgg ggctcgtgga gtacgcgacg gccgaggtcc ccgcgcgcgt
    10621 ggcgggcacc aggccgctca gggtgctgac ggagacgttc gcggacgccg tccacctgcg
    10681 caacgacctg ttctcctacc agcgtgaggt cgaggacgag ggcgagctca gcaacggcgt
    10741 cctcgtcctg gagaccttct tcggctgtac gacgcaggag gcggccgaca ccgtcaacga
    10801 catcctgacc tcccggctcc accagttcga gcacacggcg ctcaccgagg tccccgcgct
    10861 ggcgctggag agggggctca cccccggcga gaccgccgcc gtcgccgcct acacgaaggg
    10921 actgcaggac tggcagtcgg gcggccacga gtggcacatg cggtccagcc ggtacatgaa
    10981 cgagggcgcg gcctccgcgc gcggaccgct ggacctcggc ggcgcggtgc tctccggtcc
    11041 ggtaccgctg ttccgggcgg gcctcggccg acgcggcgcc gacgtgggcg ccctgctcgc
    11101 cggggccgcc gccatggggg cacctcccac gcctttcggg cagtggggga ggctgcgggc
    11161 ccacacgcac gtaccgttcc agaaggtcgg cccgtccctg ctgccgccct tccacatgcc
    11221 gttcgaggtc cggctgaacc ctgagctcga cggggcgcgg cagcgactcc tgccgtgggc
    11281 acgccgtatg ggcatcctcg ccgagggcgt ctgggacgag gaccggctcg acgcggccga
    11341 cctgccgctg tgcgcggcgg gcctcgaccc cgacggcacc ccggaggcgc tcgacctcgg
    11401 ctcccggtgg ctgacctggg gcacgtacgg cgacgactac taccccctgg tcttcggccg
    11461 caggcgcgac ctcgccgcgg cccggctgtg caccgagcgc ctgtcggcgt gcatgcccgt
    11521 cggggaggcg gagcagccgc tcctcccggc gaacgccatg gaacgcggtc tgaccgacct
    11581 ctggcggcgc accacggccg ggatgacccg ggaggcccgc cgcaccgtga gggcgtcggt
    11641 ggaggtgatg acccgggcct ggctgtggga gctgtccaac cagctccagc accgcgtccc
    11701 cgacccggtc gactacctgg agatgcgccg cgccaccttc ggctcggacc tcaccatgag
    11761 cctgtgccgc gcgggccacg gccccgccgt cccgccggag gtgtaccgca gcggccccgt
    11821 ccggtccctg gagaacgccg ccgccgacta cgcgatgctc gtcaacgacg tgttctcgta
    11881 ccagaaggag atcgagtacg agggcgagat ccacaacggc gtcctggtcg tgcagacctt
    11941 cttcggctgc ggctacccgg ccgcgctcgg cgtcgtacac gacctgatga cccagcgcat
    12001 gcggcagttc cagcacgtga cgcagcacga actgcccgtc ctgtgcgcgg acttcggcct
    12061 ctcgccccag gcgcggtccg tgctggacgg gtacgtggac cagctgcgga actggatggc
    12121 gggcatcctc aactggcacc gcgaggtccg ccgttaccgc cccgaacacc tcgcccgccg
    12181 cacccacggc ttcctgccgg accgggcacc cgcgcccctt tccgcgggtc tgccggaacc
    12241 ggtgacgctg tgaggcagga gacttttcgg ccaagagggg gcattgaggg aacttcggca
    12301 gggcttccca gagtccttcg aagtgacgga acgggcaaca cttcacgggg gagttcgacc
    12361 ttgaccgaca tgatcgagag ggccgccgac cgcaccaccg gggaccgggc gcccgccgcg
    12421 ggggaactgg cgccgtacgt ggccccgctg cccgtgccgc cgctgctgcg gccggccacc
    12481 ggagacgtac cgcacgccac cgagatcgcc gtgcgcccca cctgggtgcg gctccacccg
    12541 cagcttccgc cgaccctgat gtgggggtac gacggacagg tgccgggccc gaccatcgag
    12601 gtgcgccgcg gacagcgcgt ccgtatcgcc tggaccaacc gcgtgcccag gacggccccg
    12661 ttccccgtca ccgccgccga ggtgccccgc cgagcccagg gcaccccgcc cgccaccacc
    12721 gagccgggcc gcgggggagc cgtgccgaac caggacgtgg cggcgcttcc cgcctggctg
    12781 gtgacgcatg tccacggtgc ccagaccgga ggcggcaacg acggctggac ggacaacgcg
    12841 gtcggctccg gcgacgccca gctcgccgag tacccgaacg accaccaggc ggtgcactgg
    12901 tggtaccacg accacgccat gaacatcacc cggtggaacg tctacgcggg cctgtacggc
    12961 acgtacctcg tccgggacga cgaggaggag gccctccggc tgccgcgcgg gaagcgcgag
    13021 atcccgctgc tgctcgccga ccgcaacctg gacaccgacg aggacggccg cctcaacggg
    13081 cgcctgctgc acaagacggt cgtcgtcgag gagcgcaacc cggagacggg caagccggtc
    13141 accctgccct tcaccggccc gtacaccacg gtcaacggcc gcatctggcc gtacgccgac
    13201 gtggacgacg cctggtaccg cttccggctc gtcaacgcct ccaatgcccg cgtctaccgt
    13261 ctggtcctga tcgacgagga cgacaacccg gtgccgggcg tggtccacca gatcggcagc
    13321 gacgggggac tgctgccgcg ccccgtgccg atcgacttca ccggtgacct gcccgtcctc
    13381 agcgcggctc cggccgagcg gttcgacctg ctcgtcgact tccgcaggct ggcgggacgc
    13441 cggctgcggc tggtcgacaa gggtccgggt caggcacccg gggtgcctga cgcggtgaac
    13501 gacgtccgct atccgcaggt gatggagttc cgcgtccacg agagctgcga acgggacacc
    13561 ttcgagctgc cggaggtcct ctccggctcc ttccggcgac tcacgcacga caccccccac
    13621 ggccaccggc tgatcgtcct caccccgccc ggcaccaagg gcggcggcgg gcacccggag
    13681 atctgggaga tgaccgaggt gcacgacccg gtcggcatcc aggtccccgc ggacggcgtc
    13741 atccaggtga ccggcgagga cggcaccacg aagacgtacc gccgcacggc acgcacgttc
    13801 aacgacgggc tcggcttcac catcgccgag ggctcccacg aacagtggag cttcctcaac
    13861 ctcgccccgg tgctccaccc catgcacatc catctcgccg acttccagct gctggggcgc
    13921 gacgcgtacg acgtctccgg cttcgaccgg gcgatcggcg gcacggtgac acccgtcagg
    13981 ttcgacccgg agacccggat ccccgtcgcg cccaacgagc gcggcaacaa ggacgtgttc
    14041 caggtgccgg gcagccagac ggtgcgcctg atgggccggt tcgacggggc gtacggccgg
    14101 ttcatgtacc actgccatct gctggagcac gaggacatgg gcatgatgcg gcccttcgtc
    14161 gtgctgcccg cggaggtact gaagttcgac cacggcgcgg gccacggtgg tcacgacggc
    14221 cacgggggac acgacggccg tacgagctga tcgagccagg gccgacacaa cggcgccacc
    14281 cgctcgcgta cgcggcggcc tacgggcagg atgctgcccg taggtccccg gcgccctccg
    14341 gggaactccg gacgcacgga ggaacggatg accgatacgc ccgcgccctt caccgccgcc
    14401 gaccacgcgg cccgtctgcg gcgcgcggag tcggccgcgg cggacgccgg actcgacggc
    14461 atcctggtcg cgccgggtcc cgacctggtc tggctgacgg ggtaccggcc ggtggagacc
    14521 gagcggctca cgctgctggt gctgcggccg ggagaggagc ccgtgctggt ggtgccgaag
    14581 ctggaggcgc ccgacgcggc ccgggcggcg cccgcactgg ccctgcgtga ctggaccgac
    14641 ggccaggacc cgtaccgggc cgccgcgtcc ctgctgggcg gtaccggcgg caccggccgc
    14701 tacgccgtca gcgacaacgc ctgggcgatg cacctgctcg gcctgcagcg gcggctgccg
    14761 gacacttcgt atgtgtccct caccgacgcc ctgcccatgc tgcgcgcggt caaggacccg
    14821 gtggagctgg accgcctggc cgccgcgggc gcggccgccg acgccgccta cgaggagatc
    14881 aggaccgtgc gcttcgccgg gcggcgggag accgaggtcg ccgccgatct ggccgggctg
    14941 ctgcggcggt tcgggcactc ccaggtcgat ttcacgatcg tcgcctcggg gcccaacggc
    15001 gccgacccgc accacgaggc aggcgagcgg accatcgagc ggggcgacat ggtggtcctc
    15061 gacttcggcg gcctgaagga cgggtacggc tccgacacct cccgtaccgt ccacgtcggc
    15121 gagccggacg ccgaggagcg ccgggtacac gacatcgtgc gcgccgccca ggaggagggc
    15181 ttccgggccg tccggccggg tgctgcctgc caggatgtcg accgggccgc ccgcgcggtc
    15241 atcgacgagg ccgggtacgg cgcgtacttc gtccaccgga ccgggcacgg catcggcgtc
    15301 accactcacg agccgccgta catggtcgag ggcgaggaac ggcccctggt tcccggcatg
    15361 tgcttctccg tggagcccgg gatctatctg cccggccgct tcggcgtgcg tatcgaggac
    15421 atcgtgaccg tcaccgagga cggcgggcgc cgcctcaaca ccacctcgcg cgagctggcg
    15481 atagtcgact gaccgaccgt gcacggcggg acggagcggg accggccggg gcccgccgtg
    15541 cacggccgga ccgaccgcac cggaccccag gagccccctt tcccctacac cgggatgacg
    15601 acggcacgac catgacccag gcaccgactc ccaccgcgga caccgtccgc cgactggtcc
    15661 gttccctgct gcgcgacagc gacggacccg atgtgcagcc cgtcgccgag gacggccggc
    15721 actgcacctg gtgggtcggc acccgccatg tgctgcgcct cgcccccgac cgcgaggcct
    15781 ctgtacggct gcggcgcgag ctgcggctgc gggacctggt ccgcccgcac ctgccggtgg
    15841 ccgtcccggc gaacgtcgcg cacggcgact gggcgcccgg cctcgcgtac gccctcgacg
    15901 ccaggctgac cggcggcacc gcagaggagc acgcggtctc ggccctcggc gaggccgatc
    15961 tggcagggct gctcacgggg ctgcgcgagg tgcccgtacg gcaggcggag gcgctcggcg
    16021 tcccgcgtac cgcgccccgc tccctggaga cgctgcgtac ggccggggcg aaggcggccg
    16081 gtcacctgga ggaggccgac gagttcgccg ccggccggtt cggccggttc accccgctcg
    16141 cggcggaccg gctcaccggg tccgcacccg tgctcgtgca ccacgggctc gagggccggc
    16201 acctgctggt gagcggtgac ggccgggtgc gcggcgtcct cggctggtcc ggcgcggccc
    16261 tcggcgatcc cgccgaggac atcgcgggcc tcgccctcgc cgtcggctcc ccggccgccg
    16321 tccgtgccgc cacgctcgcc gggtacgggg cccgcccctg tctgcgcgga ctgtggctgg
    16381 cccgctgcga cgcggtggtc cggctctcgg accgtctccg ggaccgcggc gacgacccgc
    16441 ttgccctgct gcgcggccgg ctgcgccgtg cctgggagcc catcctgctg gaacgggtca
    16501 cggagctgcc gggggaggag tgagcgggtg cgcgccgggg agggccgagc ggcccctccc
    16561 ggtcacccct ggtcaccccc gggcactcct ggtcactcct ggtcactcct gggtcagcac
    16621 cacgcacgac tcgccgggca gccgcagcac tccgtccggg cccggggccg ccacgggctc
    16681 ccaggcagcc agtacgcgcg cgcggtgcac gccgagcggg atcgcggcgg gctcccggcc
    16741 caggttgacc gccacccgga tgtcgccgcg gcggaaggcg aaccagcggg cctgcccgtc
    16801 gtgggccgcc ctgacctcgg cgagatccgg gtccgacagg tcgggctggg tgcggcggag
    16861 cgcgatcagc ttccggtacc aggcgagcac gcgcgcgtgg ggctcgcggg tgggctccga
    16921 ccagtcgagg caggagcgct cccgggtcgc cgggtcctgc gggtcgggga tctcctcctc
    16981 ggcccacccg tgctccgcga actcacggcg cctgccccgg cgtacggcct cggcgagctc
    17041 cgggtcggtg tggtcggtga agaactgcca gggcgtgccc gcggcccact cctcgcccat
    17101 gaacagcatc ggcgtgaacg gcgaggtgag cgtcagcgcg gccccgcacg ccagcagccc
    17161 ggggctgagg ctcgcggaga ggcggtcgcc ctgggcgcgg ttgccgatct ggtcgtgggt
    17221 ctgcgtgtag ccgagcagcc ggtgcgccga gacgcgcgta cggtccagcg ggcggccgtg
    17281 tccgcggccc cggaacgtcg agtacgtgcc gtcgtggaag tagccgccgg tgaacgtctt
    17341 cgccagcgcg gcgaagggat cgcgcgcgaa gtcctcgtag tagccctggg actcgcccgt
    17401 gagcgcggtg tgcagcgcgt ggtggaagtc gtcgttccac tgggcgtgca ggccgtagcc
    17461 gccctgggcg cgccgggtga tgagccgggg gtcgttcagg tccgactcgg cgatcaggaa
    17521 caggggccgc tccacctcct cggcgagcgc gtccacggcc gacgacagct cctccaggaa
    17581 gtggcacgcg cgcgtgtccc tcagcgcgtg caccgcgtcc aggcgcagcc cgtccagccg
    17641 gtagtcgcgc agccacgcca gcgcgctgcc ggcgaagtac gcacggacct cgtccgagcc
    17701 gggcgcgtcc aggttgacgg cgacgcccca gggcgtgtgg tgccggtccg tgaagtacgg
    17761 cccgaacgcg ggcaggtagt tgccggacgg gcccaggtgg ttgtgcacca cgtcgaggac
    17821 cacgcccagg cccacctcgt gcgcccggtc gacgaagcgt ttcagtgcct cgggcccgcc
    17881 gtacggctcg tgcacggccc acagggagac cccctcgtac ccccagccgt gcgtcccggg
    17941 gaaggggcac aggggcatca actcgacatg cgtgacgccc agatcgacga ggtgcccgag
    18001 ccgctccgcg gccgcgtcga gggtgccctc gcgcgtgtag gtgcccacgt gcagttcgta
    18061 cagcaccgcg ccgggcagtc cgcgtcccgc ccacggcacg cgccacgcgt accgctcgtg
    18121 gtcgaccacc gcactcaggc cgtccgggcc gtccggctgg cgccgggagc gcggatcggg
    18181 cagtacggga ccgtcgtcga gcgcgaagcc gtaccgcgtc ccgtccgtcg cctccgcctc
    18241 ccccgtccac caacccgaac gcctcgtatc gcgctccaac gcgcgcgtga cgtccgcgca
    18301 atggagcgtc acccggtcgg ccagcggtgc ccacacctcg aactgcacgg acggttcccc
    18361 ttcggctgct cttcgtgacg tagcccgtcc atggtgcgcc acacacgatc agttcgctgg
    18421 cgattcggcc cgtttgcccg gcgggtgcct ccgtgaccgg aacggccggc gtcccgtttt
    18481 ctggacaccc gggcccgcac tgaccgacaa tcgccgcgtg acgtcgtcct tcgagttcca
    18541 cacgtacccc gcgcggctgt ccgacgcgga gcgcgaccgg gcgctgaagg cgctccgtga
    18601 gggcgtcgcc ctgggacgtc tctcgcacga cacgttcgtc cggcgcatgg agctcgcgct
    18661 cagcgcccgc cgcgccgacg agctggccgc gctcaccgcc gacctgccca ccgagagccg
    18721 cttgtcccgg ctggtgttcg gcacggtcga ggcggtctcc ggcttcaccg tgcggctgcg
    18781 ccgggcctgg cgcgccgagc ggctgcccaa gctgctgctg ccccaggcgg gcggcgggca
    18841 tccgctgcgc ataggccgcg accccgtcaa cgggctgcgg ctcagccacg agaccgtctc
    18901 ccgcgtgcac gccgaactga gccgccaggg cgggctgtgg gtgctgcgcg acctcggctc
    18961 caccaacggc acgaccgtca acggacggcg cgtcatcggc gcggccgtgg tccgcgccgg
    19021 tgaccaggtg ggcttcgggc gcatggcgtt ccggctggcg tcggagtgag gggccgccgt
    19081 ggaggggcat gccgccgtcc gtgctcgtgc tctccacggt gttgacgtac tgcccagggc
    19141 gtgactgact gtgcgtacac catgcacacc aggtgaaacg acggcaccac ctagtggagg
    19201 tgtgccctgc ctccactcct ccactacccg acagtggacg aactggccgt ccgcgcggcc
    19261 gcgctcgtgg cccggcaccc acgggaggcc cgcctgcgcc gcgtgggaac ctcacgcgag
    19321 ggcacaccgc tgtggctgct ctcggtgggc cacggcggcc gccacgtcct cgtcgtcgcc
    19381 gggccccacg ccaacgagcc cgtgggcggc gccacggcgc tgcgcctggc cgaacgggtc
    19441 ctcgccgacc ggcggctgcg ggagggcacc gacaccacct ggaacctgct gctgtgcctc
    19501 gaccccgacg gcgcgcaccg caacgagggc tggctggcgg gcccgtacac gctcgggcac
    19561 tacttccgga acttcttccg gccgggcttc ctggaacagc ccgagtggct ccccgagggc
    19621 gccggcggag acgtcctgcc ggagacccgc gccctgctcg acctccagga cgagctgcgg
    19681 ccctttctcc agtgctccct gcacggcgtc gacatcggcg gcggcttcgt cgagctgacc
    19741 cgcgacctgc ccggcctccc ggagcgcctc gcccggatcg ccgcccgcct cggcgtcccg
    19801 cgggaactgg gcccctacga caccctgtac tggccgacgc tcggccccgc cgtctaccgg
    19861 gtgccgccgc cgcgccccgg cgacctggcc gccgccatca cggaggccgc ggtggagtcc
    19921 acgtggttcc acccgcaccg gtacgggacg gtgaccgcga tcgtcgaggc ccccatgtgg
    19981 ggcgtgcggg ccgtggagga cgcctcggag ccggaggacg ccgacgcgct cctccgcgcc
    20041 gtcagcagga cgctgcgcca cgacacggca ctcctggagg acgtcctggc ccgcgtccgg
    20101 ccctcggtga gcaccggccc cgacgcggcc cggctgctcg cccccgtcga cgactatctg
    20161 ctggtcggcc ccggcgtcgc cgactcctgg gaccccggcg cccaccgcgg cgccggcggg
    20221 cgcccactgc cgccgctcga cacggcccgc ctcaccgccc tcgccatctc ggcccgccgc
    20281 gtcgcgctgc gtacggcggg gctgctgcac cagctcgtcc ggcggtccgg ccaggacccg
    20341 gccggcgtgc tgccccgcct ggaccggctc atcgacgcct ggtgcgccga ctaccgcgac
    20401 ggccacgggg cgcgctggat accgcccggc cgccaggtcg agtaccagtc gcgcgtggtg
    20461 ctcgccgcgt tccggctgtc cgggcgtccg cacgcgcgcg aggacccgga tcccggctcc
    20521 cctccggggg agcccggcct gggtgtgcag cgtgccgtgc cgatgcgccg cgaatgacgt
    20581 acctcaccgg cgtggggccc cggggtgccg tcaccgcgcg aaggctgccc gccggcccga
    20641 tcgccgcggc ggttcacgtc acatggtccc gggcgtgcag cgccgccgtc accacggtgc
    20701 gggcctggtg ctccacctgg ttctccaggg gcacccagcg ggcccggaag cgttccgcga
    20761 aggagccgct ccaggtggcc acgaggtctt cgagacgcgg tgccgcccgg tcgtcggcct
    20821 ctctcaggac ccgcagcagc atcgcggcgg cccgcagcgg cagccgccgc ccgaacgcct
    20881 ccacgctgcc caggtatgcc acggtcgtgt ccggtggcgt cccccgtgcc cagtccgcgg
    20941 ccagccccgg caccaggtcc agcgcccacc gggtggcccg cagcagcggc ccctccgcac
    21001 ccggcagccg gggcagcgcc tcggtgagga ttcgctccac ctggcacgcg tcccgccgca
    21061 gccgccgggc cagctccccg agcgccgcct cgggggccgg gtgcggggcg gggtcgtcca
    21121 ccaggtcgct cgcccacatc ggcacctcga ccaccgcggt cagcccgccg tgccggtggg
    21181 cgcggtacca ggtgctgtgc cgggcgtcgt ccggcacgcg cgggtgggcg gtgtccgggc
    21241 cgaggtcggg catcacgcgc acaccgggcc ccgaggcacg ccagccggcc gcgtcggagg
    21301 cgctcgtctc gaccgggatg ttcagctcgg cggcggactt cgcgaacggc tcggcgagcc
    21361 cgggaacgtc cttcgtcagc tgcacccagc tgccgccgag atcggtgccg tgcagggtca
    21421 cctggaggta gggccgcagc tcgtcgatga cgcgggtcag ggcgcgggtc tccggcggca
    21481 gccggtcggg gggcagcacc gacggcgacc actcgggctg ctcgggcccg gccgggcgga
    21541 agaacccgag gtggtagtcg aacagggtgc gcggcgccgg ggtcacgtgc aggctcgccc
    21601 cgtccgggtc cgcgcacagc aggaagtgcc aggaggttcc ggtccgcaac tcccgctcgt
    21661 ccagcacccg ttcggccacc gccagcaggg tcgagccacc cgtcggctca ttggcgtggg
    21721 cgcccgcgac gacgaggacc gcgcgcgggg cgtggcccac ggacagcagc tggaggggcc
    21781 gtcccgcgcg cgagacgccg atctgccgga aggcacacag ggcggggcgg cgggctgcca
    21841 gcgcgcgggc ggacgactcg agttccgtga cagtggggta gcgcagctcc cgcaggagac
    21901 tcacccccgt cctgtccgcc ccgttccggc ccttcgcagt gtcctcggac catgaggggt
    21961 gtcaaggagg tgacgggggc ggctccaggg ggcgcctggg ggcattatgc accggcgggg
    22021 agtcatatga ccggcgccgc ggtgttcctc agtcccggac gcgctccagc agcgccaccg
    22081 gaagccgctc gaagagctcc gccacgcgcg cgtgccccgt gaactcccgg tccggcgcga
    22141 ggacatcgct ccaccgtccg ggcggcagcg ccagcccggt gtcgcgccag ccgcccgcct
    22201 cggccagccg cagcgacagc cgggtgacgg cggtgacgac ctcgccggag cgc
//
