LOCUS       NZ_BMVW01000003        21752 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000003
VERSION     NZ_BMVW01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 638423)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 616671
            Orig. end                         :: 638423
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21752
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..21752
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21752
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:15200](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15200
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(1527..2411)
                     /locus_tag="IE242_RS12730"
                     /old_locus_tag="GCM10010365_26360"
     CDS             complement(1527..2411)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746450.1"
                     /locus_tag="IE242_RS12730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26360"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_189858426.1"
                     /sec_met_domain="APH (E-value: 1.6e-22, bitscore: 75.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSTAAPARHVLEEACAMAGLNAAGAEPVRLAENQIWRLPGRVI
                     VRIAQSGQATAAAREVRVARWLAQQGVPAVRLIDVEQPVQAQGRPVTFWKELPPQEHGS
                     PRDVAYLLRQLHALPVPDIELGYLNPFVRVTERLEAATTISDDDRAWLRGLHRDLAAAW
                     ADRPAGLPDRAVHGDAWPGNLVRAGGEPLMMDLERFSVGPPEWDLVSTAVRAKTTGAAT
                     SKEYAEFCEAYGFDVTEWEGYPILAGARELRMTTYAAQHAASNPEWADQAQYRIDCLRG
                     RSGPRPWSWKGIL"
     gene            complement(2408..3916)
                     /locus_tag="IE242_RS12735"
                     /old_locus_tag="GCM10010365_26370"
     CDS             complement(2408..3916)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378988.1"
                     /locus_tag="IE242_RS12735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26370"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_229858837.1"
                     /transl_table=11
                     /translation="MREPAATIQAERPESVQGADADSWKVRHHETGMGYMPQPEKQLDP
                     GASPAQWFGWQLRKRRKEAKLSGRALGRLVQVSDDMIHAIEKGKYPSCQQDLARRLDEV
                     LEADGLFESAWPMVFGNRDAEKKRADADKRSRGVAEATVQPLTGRILGRDEESPRSGST
                     APVDRRAFLQTSGVAAFTPIELAQAFTPTDLTWPESIGAAHIGEVREAATAISLLDNRF
                     GGGGIVRGFAGRAMQWAAGLLQVPCSEHMRSDLFAAVSHLGIVVAASEFDAYEHGAATR
                     NFLFAADCAEEAGNWHLRAKAYSFLARQAVWIGEPDDGLTYAEKGLVRSDRITPTEQAM
                     LYTAKARAFGKMGMVRECMKAVGEADEAFTDARPSEDPPWMKYYDEAQHNGDTAHALFD
                     LVILTGQDPGRTARRFDTAVKKHSDDYKRSRAISRTKLASLLMAEGDPRQAATIGHQAL
                     DEVGRLTSRRAADDLRQLSAFAAKHPHTPEAVHLRERIASTVST"
     misc_feature    complement(3695..3697)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3979..4431
                     /locus_tag="IE242_RS12740"
                     /old_locus_tag="GCM10010365_26380"
     CDS             3979..4431
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="IE242_RS12740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26380"
                     /product="ATP-binding protein"
                     /protein_id="WP_189858427.1"
                     /transl_table=11
                     /translation="MNGTVSGSREGNSIWTVPKVGRGVLTLRFDVEAEHLSVIRRILGD
                     VLEWWGIDPDVQERLVTAVNELLSNVLEHTEPDLNGCHIAELRIQLVPGGISAVVGDRD
                     DRVPAPRPVSSLAEAGRGLTLVRALVDEMNVTRRLSGKDIWVFVAA"
     gene            4544..5518
                     /locus_tag="IE242_RS12745"
                     /old_locus_tag="GCM10010365_26390"
     CDS             4544..5518
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS12745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_26390"
                     /product="hypothetical protein"
                     /protein_id="WP_189858428.1"
                     /transl_table=11
                     /translation="MKLDDMSLIIHPAGRDEALRVVLEDLRMGHWHSTRDLLARTGDDW
                     ALRTARSQVIACVDLDAENVRAWRQEEPHHPDALMLWARTLTEGVLTAGRRGTVPYDVV
                     ERARRACGNASQAYPADPVPWVCQLALTALDTDPMNPHRPHHWGRTQDPMLPRGPWQLL
                     DQVHARHPEGSREAFLRMYQCLHARRYGALDFACWANQVAPEGSPVLPLVLHAYAALAR
                     ERLGNGQIGNTLGFWQDSQVVYYTERARDHWFRKLSDPEAAPLTDLNHLAYALSATGLS
                     GAAEVFEAIGPYATPAPWEGLSIGGDWIHDFHTARRGALRRWR"
     misc_feature    4559..4573
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.14"
                     /tool="antismash"
     gene            5608..7113
                     /locus_tag="IE242_RS12750"
                     /old_locus_tag="GCM10010365_26400"
     CDS             5608..7113
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031371.1"
                     /locus_tag="IE242_RS12750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26400"
                     /product="amino acid permease"
                     /protein_id="WP_189858429.1"
                     /transl_table=11
                     /translation="MSAPYSDDPTDDGVLQALGYKPVLARRMSGFGNYAISFSVICPLA
                     GCLTLFGFGLNTGGPAVMMWGWVIIGFLTLLVALSLAEVTSAYPTSGGLYYMAHQLGGP
                     RWGWFTGWFNLLGLLGAIAGIDYGCALFVGAFANLQWGITPTPELTMWIFAGILLLHGT
                     LNTAGVRLASILNSISVWWQVCGVALIIGALSLAPAEHQDVSFVFGQFENGTGFSSAVY
                     VCMIGSLLAAYTFCGYDASSHLSEETKNAQIAAPRGMVRSVWTAWIVGFLLLAGLLFAI
                     QDYAGTVATATGVPPAQIMLDVLGATTTKLLLLVVIVAQLFCGNAETAAASRMVYAFSR
                     DGALPGSHLWRRVNRNSTPVAAVWASVGVALLIALPSLYSPTAYAAVTAINVIGITPAY
                     IIPVYLRRRHSARFTPGPWTLGRWSGPIGWTAVAYVIVITIVFCLPQASPITVSSFNYA
                     GVTALAMIILAAAMWKVRGKSQNYKVPTLGNIDEQTEFTRSVL"
     gene            7329..8150
                     /locus_tag="IE242_RS12755"
                     /old_locus_tag="GCM10010365_26410"
     CDS             7329..8150
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021608.5"
                     /locus_tag="IE242_RS12755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26410"
                     /product="zinc-dependent metalloprotease"
                     /protein_id="WP_189858430.1"
                     /transl_table=11
                     /translation="MFCTVLDDTQRNSELKESIEQLLIIVAPHVRQLTGLPAPSNEVRF
                     RLLEPKAWRHECGQHTRRVLDRDRANLDLVLTPEQLEGADIAVKITGFLPAVIWPLFSA
                     LTVEAGDGGSETIIAPRALHHTGLVDEAPLLCQLVAHELTHHFQAVAGAPWRTLFPRER
                     RICPRGAVTLVKGHAHWVAQQVTCRVFGRPVDHHEHAHRSLRYQLAKGVCHLPLFAGVR
                     HDAYLRGVAFVHHVVHERGTDPINRAWNDHTLLPTADEISDPGAWIRRTAA"
     gene            8188..9567
                     /locus_tag="IE242_RS12760"
                     /old_locus_tag="GCM10010365_26420"
     CDS             8188..9567
                     /EC_number="6.3.1.-"
                     /GO_function="GO:0004356 - glutamine synthetase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006542 - glutamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009315161.1"
                     /locus_tag="IE242_RS12760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26420"
                     /product="glutamine synthetase family protein"
                     /protein_id="WP_189858431.1"
                     /transl_table=11
                     /translation="MTTHNEAQPSTPTGMITLDGLENWVDEGLITTVLPVLPDMGGNLR
                     GKRLAAGKFMQAASQPGRPVAEACAYVLATDIDMSPAQDYDLTSWMAGFQDIAAMPDLG
                     TLRVLRHQSGTALVHCDAAHPGGQPVPVAPRHLLRQQLDALTSEHGVELRAGLENEVVL
                     YDATTLRPVTQHNLDYALQHPRALTDFFTQLERALAFSATPAESVKTEGAPGQIEVAFP
                     YGPAMRACDDYTVYKHLLKEIAGEHGMLPTFMAAPQTGTASGLHVHVSLWQGDEPAFAA
                     TGPAELPEAMRHAIAGLLAALPDLAPLYAPNPNSYRRYQPYSFAPTHYTWGVDNRTCAI
                     RVTGHGAGAHLEVRLPGADANPYLAVAAVCAGINYGLAHKMDPPEPWTGDGYEAEAGKG
                     VVPVPSSLTTAARALESSSIANKYFGRDVVTHYATAAYQEVMTLGRLVPDTEINRYRER
                     I"
     misc_feature    complement(9725..9738)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            9728..9916
                     /locus_tag="IE242_RS12765"
                     /old_locus_tag="GCM10010365_26430"
     CDS             9728..9916
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="IE242_RS12765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26430"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_189858432.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.5e-16, bitscore:
                     55.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQLERPIAPTQPDAEAVHDATDPFNLDITFIEGTPATETVLMC
                     STGDTCGSSCPSACVTS"
     CDS_motif       9728..9847
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTIQLERPIAPTQPDAEAVHDATDPFNLDITFIEGTPATE"
                     /locus_tag="IE242_RS12765_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9848..9916
                     /prepeptide="core"
                     /locus_tag="IE242_RS12765_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.20"
                     /molecular_weight="1948.2"
                     /monoisotopic_mass="1946.8"
                     /core_sequence="TVLMCSTGDTCGSSCPSACVTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTIQLERPIAPTQPDAEAVHDATDPFNLDITFIEGTPATE"
                     /leader_location="[9727:9847](+)"
                     /alternative_weights="1966.2"
                     /alternative_weights="1984.2"
                     /alternative_weights="2002.3"
                     /alternative_weights="2020.3"
                     /alternative_weights="2038.3"
     gene            10001..12040
                     /locus_tag="IE242_RS12770"
                     /old_locus_tag="GCM10010365_26440"
     CDS             10001..12040
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="IE242_RS12770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26440"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_229858838.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.4e-15,
                     bitscore: 52.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.8e-102,
                     bitscore: 337.9, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRARHRLYRGTGQGMLRAAVSVDEPVMAPWPGRSASLDDWRVWL
                     GTVWADETFRQAVGSASPDLAGQVQAILGGRAPKLRRVRRAALATARYAIRYARRSTPY
                     GLFAGVAMIEFGDTANIRFGDRHQAVTRPDPVALDEAISAWEADATRMTDVDVCVHPLA
                     QQRDGHVCVPSEGDAEFRLALSSPALRFVLDAAHAPIRYSVLADKLAAEFPTTAEGARI
                     QLLGELLRVRLLRSSLRAPATVVDPAEALPPALRAQVRDLATVADLRLDATVQLPQAVL
                     TEAETAATVLARLATHPNGTPAWCRWIEQFTDRYGENTAVPVEVATDAERGVGFPDGFV
                     KMVEPPRPMSRRDRLLLELAGTAAVAGARSVPLTGAMIEELEAVGDKPRLTAPHLELAA
                     QIHAPSAEALERGNFRLQVATVSRSAGSMTGRFWHLLPEAGVPHTALPTMEPGAEVAQL
                     SFHAGRVPADLLTRAPRVLPRIVSVGEFRHPGDGVLFPADLAVSVRDGRPRLVEIATGT
                     HLELLAPTAINFLWNNYTPPMARFLGEISRATAPQVTWFDWGVAWALPFTPALTYRRSV
                     LTAARWKVRARDLPGRTTALKEWAEHLHAWRDRLRVPDRVLLAEDDQQLPLDLHQDMHL
                     DLLRAHLDASPIGVATLHEAPPADADNWIGGRAHSLVLPLVARA"
     aSDomain        10469..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE242_RS12770_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.30E-16"
                     /identifier="RREFam001.1"
                     /label="IE242_RS12770"
                     /locus_tag="IE242_RS12770"
                     /protein_end="241"
                     /protein_start="156"
                     /score="52.1"
                     /tool="antismash"
                     /translation="VCVHPLAQQRDGHVCVPSEGDAEFRLALSSPALRFVLDAAHAPIR
                     YSVLADKLAAEFPTTAEGARIQLLGELLRVRLLRSSLRAP"
     misc_feature    10751..10753
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11765..11767
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12037..13110
                     /locus_tag="IE242_RS12775"
                     /old_locus_tag="GCM10010365_26450"
     CDS             12037..13110
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326267.1"
                     /locus_tag="IE242_RS12775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26450"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_189858433.1"
                     /sec_met_domain="LANC_like (E-value: 5.9e-32, bitscore:
                     105.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTLPPRTQDLSEGPLGIALLDIERGDLTAARRHLAQGIAHGV
                     STGGNASLFHGAPALEFVLARAGHAGPDIREVVDRVVDARLVAARRRQSSGALPDLTEW
                     DHIRGLAGLGALLLTRPVPSTRLTDVLLYLVSLSQPVYSQGKRLPGWWSAVGPGGEEMA
                     GGHSNNGMAHGIAGPLSVLSLAARHDVLVPGQHEAIEVFARWLDRYGGHYWTTRAHLDA
                     AEPPEPGPARPSWCYGRPGIARAQQLAALALGDRARRQRAEDTVVRTLTDPAHLARITD
                     ATLCHGWAGLVTLARAVAADSPAPERFAPLINDLQQRLATDLDQLSKPGFMEGRSGARL
                     ALDGTNATNWTSVLLIT"
     gene            13149..15200
                     /gene="fxlM"
                     /locus_tag="IE242_RS12780"
                     /old_locus_tag="GCM10010365_26460"
     CDS             13149..15200
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="IE242_RS12780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26460"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_189858435.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-20, bitscore:
                     69.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 6.5e-44, bitscore: 145.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFDDENLPITHDTTWWHASVAFPGGAVSPAAAQALSAALHDQRF
                     HFLRKDAGLRLRTERPCAALLDRLVAEQQITGWIRGIYEPETEAFGGPEGMDVAHAVFC
                     ADSRSALPETGSSGTRERCVMLLSVMIREAGLDPFEAGDVWSQFAALRPSVDPPAGPAL
                     DRSVAAMRRLVNADAARRPDAEPGWTDRVAAFADAGRRLRRLAADGRLIRGLRAVLAHH
                     AIFACNRAGIPVAEQAATAWLGRQVAFSTTADTPVPTRWSASPDPDLPRMEITVTPVTD
                     PVELRASLANRLQESGHLRTPAIIDAFRTTDRHEFLPGVDLESAYKEDAVPIKHDEHGE
                     MISCISAPSIVATQLEQLDARPGHTVLEAGAATGYNAHLLGKLVGPSGQVWTLDVDQDL
                     VDGANKNLAQAGATNVTAVLADGAAGLPEHAPYDRIQFTVGAGDVPAKLLDQLAPGGRL
                     VLPMRIRGSISRSFAFERDGDTWRTVSCEMCTFIPLRKGVCDDIYTLVPMAGDGNVRLE
                     TFSEQEVDRDALRTVLDTPQTKIFTGVKLRQGDPFEWLYLYLACALPNGLSRMPGSRPG
                     FTPHFGWGSMAALDGDSLAYLTIREGADDAGRFWEIGVIGHGSHGADLADRFVTEIRTW
                     DEGWGNTAPEPGFRMAVGDARGRLTVADPRFVIDKAHSRLVVDWPRKG"
     gene            15205..16302
                     /locus_tag="IE242_RS12785"
                     /old_locus_tag="GCM10010365_26470"
     CDS             15205..16302
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="IE242_RS12785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26470"
                     /product="hypothetical protein"
                     /protein_id="WP_189858436.1"
                     /transl_table=11
                     /translation="MIPAIASRIPLVKRPKAPALPLDERITHLTGLTVAPAGASHHDRV
                     ARACGVLNYAALIASDAGMPALAADLCWRQHRIFASARHLTGDIAVMSLMPLINISRLL
                     TRDGDGHAAYDVLTRLYRAAQQRGTAEIHGHVIDLPALISTDADHRKICQELWVALLVD
                     GARALARIGCWTKAAEAMTAHRGIGHRLLDGRQIMIMSLMERGLDEQARSMVETTAFTE
                     PWENAVAALLRVHCRPDVATAPQPEVDLALQEAVAVVAQPDAAAAAFQARVGLAALDLV
                     CDRTSPHAAHLCSAIADVAVLDAYAARDVLHRDAEGSCLSAEQRQELNAVLTAAGLGTG
                     ELPPAHMQALAEAVDEAERALRDLL"
     gene            16505..18394
                     /locus_tag="IE242_RS12790"
                     /old_locus_tag="GCM10010365_26480"
     CDS             16505..18394
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669697.1"
                     /locus_tag="IE242_RS12790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26480"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189858437.1"
                     /transl_table=11
                     /translation="MTSTATNEQQHTAPPPPPPAEITYSGQYSVNPLAEVSFRRMCAQI
                     PAVLGRIARLSWRTDRRAVQLLLGCQVVTGVAAAVLLAATAHAMEPVLGDGTAADRLRG
                     ALPALLVVALAAALGRGAGAVATYAERRITPRLTTQTDTAVVEAVCRVEAAAYAEDGFS
                     DRHEAAEMGVIRTHVMVTDAQRFLSALIRMVTAGGVLSVLNPLMLPLLLLAVLPAGVGA
                     VLTARVDYEIHYANIADRNVRGMMRWWATTPKYGDEVRANSMTDYLVYWYRALSDRCDR
                     RTVAAAPRTLRIALLSALAGGVFLVATWGALAWLAVSGRIELAVAATAVIAVQTTLAAL
                     SQVVVGGAAVFHTSLYLGDMQSFLDEAAARAPRRGPRTHAAPTEEIRLEEVVYQYPGKD
                     KPAVDGVSLTLRRGQILAIVGANGSGKSTLTRLLTGIYLPDKGKVTWNGTDLAEVDPAT
                     VWAHTGLVPQIFAQWPLRVRENVTLGQPRTHDDAPVWEAIDAVGLRAAVDDLPAGLDTL
                     LSRDVFGGCELSGGQWQRVACSRALYRRPGLLILDEPTSQMDPRGEHQIFEQIKAIAAD
                     RITIVVTHRLENTKIADHIVVMEHGRITEQGRYDDLVHGGGTFAELLELSQDR"
     gene            18555..19439
                     /locus_tag="IE242_RS12795"
                     /old_locus_tag="GCM10010365_26490"
     CDS             18555..19439
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236941.1"
                     /locus_tag="IE242_RS12795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26490"
                     /product="phosphotransferase enzyme family protein"
                     /protein_id="WP_229858840.1"
                     /transl_table=11
                     /translation="MSQTKPLPATVRRWAEQRIGPVVTVRDASHDWDRSRVWELQGAGG
                     ARRYVKVSPSEKFFTRETRAYRHVVPALGPSRAPHLVDSRAQDLALLLTAVPGTPAPGL
                     GLTPGAWRAVHRQAGALCARLHEAGDLDRADRAEAEASLEAAADGAEKHLARAGDRLTA
                     DEQQMIRDHAAQLRRVGPVPVGYIHGDNQPRNWLWSPAGLALVDFERTRPAARVQDLVI
                     LTVTEWLDHPDREQAFLQAYGRALTPAERHALRCLTALDAVNCLAWGPDNNQPEVTARG
                     RRTLDRLMRENRT"
     gene            19436..19912
                     /locus_tag="IE242_RS12800"
                     /old_locus_tag="GCM10010365_26500"
     CDS             19436..19912
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236942.1"
                     /locus_tag="IE242_RS12800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26500"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_229858844.1"
                     /transl_table=11
                     /translation="MSDVHRSIAHVMVLLQRPSDGRVLTVRHQPHSWHSPGLLTVVGGR
                     LEAGEFFDEGAARELAEEVGIRITPNRLEFCQLAHLHASDGERVVGAVFLARSWEGEPY
                     NREPRTHSELVWIDPTSPPEDCHPFTHEILRHFTAGHRYANVVAPELAAGGKAG"
     gene            19909..20097
                     /locus_tag="IE242_RS12805"
                     /old_locus_tag="GCM10010365_26510"
     CDS             19909..20097
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS12805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_26510"
                     /product="hypothetical protein"
                     /protein_id="WP_189858439.1"
                     /transl_table=11
                     /translation="MTVAVLAPRATARTTPAYRYLLGGEATSDHRGSYPSSCYWLPHPR
                     SAEHAHPARPRDRAARS"
     gene            20107..20691
                     /locus_tag="IE242_RS12810"
                     /old_locus_tag="GCM10010365_26520"
     CDS             20107..20691
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662491.1"
                     /locus_tag="IE242_RS12810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26520"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_189858440.1"
                     /transl_table=11
                     /translation="MTTESPAAAAYWERLWADGRRYRQLGDTEIRLLEDHLRPGRARPA
                     LDLGCGDGALARHLEQLGYRTTGIDCSPSAVALAAADQDSGPGHGPVWRCMDITTDDLN
                     ALPDRAYAVITSRLVYRWIDDKAAFLDRARRLLAPGGLFWVVTEISGRRADTDPLQHLG
                     ITPAEAEILTAGWSVVHTADLDVLRCYALRP"
     gene            20723..21472
                     /locus_tag="IE242_RS12815"
                     /old_locus_tag="GCM10010365_26530"
     CDS             20723..21472
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (48-147). E-value: 1e-07. Score:
                     22.3. Matches aSDomain: nrpspksdomains_IE242_RS12815_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580423.1"
                     /locus_tag="IE242_RS12815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_26530"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_229858846.1"
                     /sec_met_domain="PCMT (E-value: 9.1e-08, bitscore: 27.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTETHTVETWNIYGAHQLARKLQLPELDRWDWGIPDTGPGIEAL
                     GDVKGLRVLDVGSGLGRHAAHLAALGAEVTAVDASPAQHQRALARYPDTPGLHLVCADA
                     VAHLRDADPYDLIYSIGSMPYLNPDRLLPALANGLKPGGRLVFTALHTNSHGTGPSAEV
                     TRRPEILRLPGTTEDHPVDMWVLTPQLWEGLLLQHGLTMDSVTAIDSPKPDNHLSYRLY
                     AGRRPQHVPSGPRISAPPPPNTALGST"
     aSDomain        20867..21163
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE242_RS12815_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.00E-07"
                     /label="IE242_RS12815_oMT.1"
                     /locus_tag="IE242_RS12815"
                     /protein_end="147"
                     /protein_start="48"
                     /score="22.3"
                     /tool="antismash"
                     /translation="KGLRVLDVGSGLGRHAAHLAALGAEVTAVDASPAQHQRALARYPD
                     TPGLHLVCADAVAHLRDADPYDLIYSIGSMPYLNPDRLLPALANGLKPGGRLVF"
     gene            21475..21648
                     /locus_tag="IE242_RS12820"
     CDS             21475..21648
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="IE242_RS12820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_189858444.1"
                     /transl_table=11
                     /translation="MHGSDGVLLGWHRHRMWKLAGGTVELGRTFAQAAIRVLREGTGLM
                     ASPATYRCWARS"
ORIGIN
        1 gtctcagatt tacatcgccg aggcactcgg gctgccgacc gaaatcgtgg acccggcgtc
       61 ctggccgtac tggttgcccg aagcgggcgt catcccgctc ggcccggcca gccgcgtcgt
      121 gctagccctg cgagaggcgt tgaaggaatc catggaccgc tcccgccgca ccgtcctgac
      181 cgcgatctcc agcacggctt tgatcactct ggccggtacc tgggcaggca cggaggcgtg
      241 gacaccagca gtggaggcca ccagcggcaa accggttagt gacgagttcg tcgccttcct
      301 cgaggagacc agtgcgcggc tgaccgccat gccgatcgag caccgcgagg acaccgcgcc
      361 tctgctggaa gcccatctgg cgacggtgac cgagctcatc gccgacgggc actacgcccg
      421 ccccctcgga gtgcgcctgc acgcgctggc cgcatccatg gcacagaccc tggcctggca
      481 tcgcttcgac cacggcttgc acgcacaggc caccaaatac tgggtggccg gcctacacag
      541 tgcccacgcc ggcggtgacc gcgacatggg cgccgccctg ctcggggatc tggcctatca
      601 agcctcctgg cggaacgacc cccgcgcggc tgcgggaatc ctcgagcgcg ccctcacccg
      661 cacgcatcac ccagcagccc agtccttgct tcaccttcgt ctcgggcgtg cgctggcggc
      721 acagggggaa cgccgcggca ccctccgcgc gctcgaagca gccgagcact tgctggggac
      781 atcgtcgggc gaacccatcc caggctggtg ctcctggctc tccgaggccg acctgctcgt
      841 cgactccggg caaagcctcc ttgacctggg cgaaacccgt cgcgcacacc agctcatccg
      901 ccaaggccaa gacctcctgc cgcccagccg tggcaagaca cggggagtgt tccttaccta
      961 tcaggccgcg agccatctcg acgtaaggga gccagaactc gccgctgcgg ccgctctcga
     1021 gtccctggac ctcgcccagc gagtcggggc cccccgctgc gtgcagctcg tacacgacct
     1081 catcccgcgg ttcgaggaat accgaaccgc ccagggcgtt cccgaactcc tggcacgagc
     1141 cgctgcgtga gcgcccgact cagcggtgtg gatgggtggc gccgtgcacg tagccgatca
     1201 gcatccgcag ccgggccgac tccctcatgc cgagggcatc gaccctcgtg cgccacgccg
     1261 tgttgatgaa ctctgggctc ggcctcgtcg caacggcatc gcactgggga caatcgaggg
     1321 cgtgccggag tacgcctcga tcaccacgct cgacgcgctc cttgccgacc tgcgggtcgg
     1381 cgaagagcgg cggcgccagc tcgccatgga cgcggagagt tggagcgcgc tccggcccgg
     1441 ggcaggccgc ccgcaggcgc ccggcgcagc ctgcggcgtc tactggagaa ggaggcgctg
     1501 gctccggtgc gcgacgggcg cgccaatcag aggatgccct tccaagacca aggccgcgga
     1561 ccggatcgac cgcgcagaca gtcgatccgg tactgcgctt ggtccgccca ctcagggttg
     1621 gatgctgcgt gctgggcggc gtacgtcgtc attcgcagtt cccgggcacc ggccaggatg
     1681 ggatacccct cccactcagt gacgtcgaat ccgtaggcct cgcagaactc ggcgtactcc
     1741 ttgctcgtgg ccgcgcccgt cgtcttcgcg cgcaccgcag ttgacaccag gtcccattcc
     1801 ggagggccga cagagaagcg ttccaggtcc atcatcaggg gctcaccacc tgcccgtacg
     1861 aggttgcccg gccaggcgtc accgtgtacg gcccggtccg ggagtccagc tggccggtcg
     1921 gcccacgccg cggcgaggtc cctgtggagg ccgcggagcc acgcccggtc atcgtccgaa
     1981 atcgtcgtag cagcttccag ccgctcggtg acccggacga acgggttcag gtagcccagc
     2041 tcgatgtccg gtaccggaag tgcgtgcaac tgccgtagca ggtaggcgac gtcgcggggg
     2101 gagccgtgtt cctgcggtgg gagttccttc cagaacgtga ccggccgtcc ctgtgcctgg
     2161 actggctgtt cgacatcgat caagcgcacc gcggggacgc cctgctgggc gagccaccgt
     2221 gcgacacgca cctcgcgggc cgccgcggtg gcctgcccgg actgggcgat ccgcacgatc
     2281 acccggccgg gaaggcgcca tatctggttc tccgccaggc gaacgggttc cgcgccggcc
     2341 gcgttcagac cggccatggc gcaggcttct tcgaggacgt ggcgggcagg ggcggcggtc
     2401 gatgtcgtca tgtcgagacc gtacttgcga tgcgctcacg gaggtggact gcttcaggag
     2461 tgtgcggatg cttggcggcg aaggccgaga gctgcctgag gtcgtcagcc gcacgccggg
     2521 aggtcagtcg accgacctcg tccagcgcct ggtggccgat cgtcgctgcc tggcgcgggt
     2581 ccccctcggc catgaggagg gaggccagct tggtgcggga gatcgctcgg gaccgcttgt
     2641 agtcgtccga gtgcttcttc accgcggtgt cgaagcgacg ggccgtgcgg ccgggatcct
     2701 gcccggtgag gatcacgaga tcgaacaggg cgtgagcggt gtcgccattg tgctgtgcct
     2761 cgtcgtagta cttcatccac ggcgggtctt cggaggggcg ggcgtccgtg aaggcttcgt
     2821 cagcctcgcc gacggccttc atgcactccc ggaccatgcc catctttccg aacgcgcggg
     2881 ccttcgccgt gtagagcatg gcctgttccg tgggagtgat ccggtcggag cgcaccaggc
     2941 ccttttccgc gtacgtcagc ccgtcgtcgg gttcgccgat ccacacggcc tggcgggcga
     3001 gaaagctgta cgccttggct cgcaggtgcc agttccctgc ttcctcggca cagtcggccg
     3061 cgaacaggaa gttccgggtg gctgcgccgt gttcgtaggc gtcgaattcg gaagcggcaa
     3121 ccacgatgcc caagtgggaa acggctgcga agaggtccga tcgcatgtgc tctgagcagg
     3181 gcacctgcag gaggcccgcg gcccactgca tcgcccgtcc ggcgaaaccc cgaactatgc
     3241 cgccaccgcc gaagcggttg tcgaggaggc tgatggcggt ggccgcttcc cggacttcac
     3301 cgatgtgagc cgcgccaatg gactcgggcc atgtcaggtc ggtcggcgtg aacgcctgag
     3361 cgagttctat tggtgtgaag gcggctacgc cgctggtctg gaggaaggcg cgtcggtcca
     3421 caggtgcagt gctcccagag cgaggagatt cttcgtctct gcccaggatg cggcctgtca
     3481 gtggctgaac cgttgcctcc gccacccctc gggaccgttt atcggcatca gcgcgcttct
     3541 tctcggcatc gcggttgccg aacaccatcg gccaagcgct ctcgaagagg ccgtcagcct
     3601 ccaggacttc gtccagccga cgggccaggt cctgttgaca cgagggatac ttgcccttct
     3661 cgatcgcgtg gatcatgtcg tcgctgacct ggactaaccg accaagcgcc cttcctgaca
     3721 gcttcgcttc cttccgccgc ttgcgtagct gccacccgaa ccactgcgcg ggcgaggctc
     3781 ccggatcgag ctgcttctct ggctgcggca tgtatcccat tcccgtctcg tgatgccgaa
     3841 ccttccagct gtcggcatcg gccccctgca cactctcggg ccgctctgcc tgaatggttg
     3901 ctgccggttc tcgcaccagt acacaccgca ccggacctga acggcaaagg atgagcaaga
     3961 gcggacggag cagccaccat gaacggaacg gtcagcggtt cccgcgaggg gaattccatc
     4021 tggacggtgc cgaaagtggg acgtggtgtg ctcaccctga gattcgatgt cgaagccgag
     4081 cacctgtcgg ttatacggcg catcctcggc gacgtcctgg aatggtgggg catcgatccg
     4141 gatgtgcaag aacgtctcgt cacggcagtc aacgagctgc tcagcaacgt cttggagcac
     4201 accgagcctg acctcaatgg ctgccacata gctgagctcc gtatccagct cgtgccgggc
     4261 ggtatcagcg cggttgtcgg cgacagagat gacagggtgc ctgcacccag gccggtgagc
     4321 agtctcgccg aggccggccg cggcctcact ctcgtgcgcg ccctggtcga cgagatgaac
     4381 gtgactcggc gcctctccgg caaagacatc tgggttttcg tcgcagccta gaccgcactg
     4441 acgaccagtt ctccaatccg accactcccc caaggccctc gactcccatg cccttgactc
     4501 cagccctgcc ctatgtccgc aagtacgcgg gggaggcacc tcggtgaagc tcgatgacat
     4561 gtccctgata attcatcctg ccggacgcga cgaagccctc cgcgttgtgc tcgaagatct
     4621 gcggatgggc cactggcatt cgaccaggga cctgctggcc cgcacaggcg acgactgggc
     4681 tctgcgcacg gcgcgcagtc aggtgatcgc ctgcgtggac ctcgacgccg agaacgtccg
     4741 cgcatggcgc caggaagaac cccaccatcc cgacgccctg atgctgtggg cgcgcaccct
     4801 caccgagggc gtgctcaccg cgggccgccg cgggacggtg ccgtacgacg tggtggagcg
     4861 ggcacggcgt gcgtgtggga acgcgtccca ggcctacccc gccgatcctg tgccctgggt
     4921 gtgccagctg gcccttaccg cgctcgacac ggacccgatg aacccccacc gcccccacca
     4981 ctggggacgg acgcaggacc cgatgctgcc ccgcggccca tggcagctcc tggaccaggt
     5041 ccacgcgcgc caccccgagg gctcgcgtga ggcgttcctg cgcatgtacc agtgcctgca
     5101 cgcccgcaga tacggagcgc tcgacttcgc ctgctgggcc aaccaggtcg cccccgaggg
     5161 ctccccagtg ctgccgctcg tgctgcacgc ctacgccgcg ctcgcccggg aacggctggg
     5221 aaacgggcag atcggcaaca ccctgggctt ctggcaggac agccaggtcg tctactacac
     5281 cgagcgcgca cgcgaccact ggttccgcaa gctgagcgac ccggaagccg cgcccctgac
     5341 cgacctcaac cacctggcgt acgccctgtc ggccaccggc ctgtccggcg cggcggaggt
     5401 gttcgaggcg atcggcccct acgccacccc cgccccctgg gagggcctaa gcatcggcgg
     5461 cgactggatc cacgacttcc acaccgcgcg ccggggcgcg ctacggcggt ggagatgacc
     5521 cgcagccgag cacccccgag cccccacgtg tccgcccctg tcactcccca tccacatgcg
     5581 aggaaaacca cggtgtccgc gagacgaatg tctgccccgt acagcgacga cccgaccgac
     5641 gacggcgttc tgcaggcgct cggctacaag ccggtcctgg cccgccggat gagtggcttc
     5701 ggcaactacg ccatctcgtt cagcgtgatc tgcccgctgg ccggctgcct gacgttgttc
     5761 gggttcggcc tgaacaccgg cggcccggcc gtcatgatgt ggggctgggt catcatcgga
     5821 ttcctgaccc tcctggtggc cctgtccctg gcggaggtca cgtccgccta ccccacgtcc
     5881 ggcggcctgt actacatggc ccaccagctc ggcgggcccc gatggggctg gttcaccggc
     5941 tggttcaacc tgctcggcct gctcggcgcc atcgccggca tcgactacgg atgcgcactg
     6001 ttcgtcggtg cgttcgccaa cttgcagtgg ggcatcacac cgacacccga gctgaccatg
     6061 tggatcttcg cgggcatcct gctgctgcac gggacgctga acacagccgg cgtgcggctg
     6121 gcctccatat tgaacagcat cagcgtgtgg tggcaggtgt gcggcgtcgc cctcatcatc
     6181 ggcgcactga gcctggcgcc ggccgagcac caggacgtga gcttcgtctt cgggcagttc
     6241 gagaacggca cgggtttcag ctccgccgtc tacgtgtgca tgatcggcag cctcctggcc
     6301 gcgtacacgt tctgcggata cgacgccagc tcgcacctgt cggaggagac caagaatgcg
     6361 cagatcgccg cgcctcgcgg catggtccgc tccgtgtgga ccgcctggat cgtcgggttc
     6421 ctgctgctgg ccggcctgct cttcgccatc caggactacg ccggcaccgt cgccaccgcg
     6481 accggtgtgc cgcccgccca gatcatgctc gacgtcctcg gcgcgaccac caccaagctc
     6541 ctgctgctcg tcgtcatcgt ggcgcagctg ttctgcggca acgcggagac ggcggccgcg
     6601 tcccgcatgg tgtacgcgtt ctcccgggac ggggccctgc ccggctcgca cctgtggcgg
     6661 cgcgtcaacc gcaacagcac acccgtggcc gcggtatggg cctccgtcgg tgtcgccctg
     6721 ctgatcgcac tgcccagcct gtactcgccg accgcctacg cggccgtcac cgcgatcaac
     6781 gtcatcggca tcaccccggc ctacatcatc cccgtctatc tgcggcgccg gcactccgcc
     6841 cgcttcacgc ccggcccgtg gactctgggc cgatggagcg gaccgatcgg ctggacggcc
     6901 gtcgcctacg tcatcgtcat cacgatcgtg ttctgcctgc cacaagcctc gcccatcacc
     6961 gtcagcagct tcaactacgc cggcgtcacc gcgctcgcca tgatcatcct ggcggcggcg
     7021 atgtggaagg tccgcggcaa gagccagaac tacaaggtgc cgaccctcgg caacatcgac
     7081 gagcagaccg aattcaccag gagcgtcctg tgacgccgat ctggccagat ctccgcatcc
     7141 gccctgcaac gacgggcggc tgcggatgaa gggtgggggg aggccaccct tccctcgggc
     7201 ctccccccac ctctgcgctc cgtcccgccg cccatcgggg cgtcacaccc cgggcggcgg
     7261 ggcggtccga gcgggcacgt cggctcgccg cacagcaacc ccagctcacg atttcagacg
     7321 ggatcctcgt gttctgcacc gtcctcgacg acacccagcg caactccgag ctcaaggaga
     7381 gcatcgagca gctgctgatc atcgtggcgc cgcacgtacg gcagctgaca ggtctgcccg
     7441 ccccgtcgaa cgaggtccgc ttccgcctgc tggagccgaa ggcgtggcgg cacgagtgcg
     7501 ggcagcacac tcgccgcgtc ctggaccgcg atcgcgccaa cctcgacctt gttctcacgc
     7561 ccgaacagct ggagggtgcc gacatcgccg tcaagatcac cggcttccta ccggctgtga
     7621 tctggccgct gttctccgcc ctgaccgtgg aggccggtga cggcggcagc gagacgatca
     7681 tcgccccccg ggcactgcac cacaccggcc tggtcgatga ggcgccgctg ctctgccaat
     7741 tggtcgccca cgaactcact caccacttcc aagccgtcgc cggagcaccg tggcgcacgc
     7801 tcttcccccg tgagcgccgt atctgccccc gcggtgccgt aaccctggtg aaggggcacg
     7861 cccactgggt tgcacagcag gtcacttgcc gcgtgttcgg caggccggtc gaccaccatg
     7921 agcacgccca ccgctctctg cgataccagc tcgccaaagg cgtatgccac ctcccgctct
     7981 tcgccggcgt gaggcacgac gcctacctgc gcggggtggc cttcgtccac cacgtcgtcc
     8041 atgagcgcgg cacagacccg atcaaccgcg cctggaacga tcacacgctg ctgcccaccg
     8101 ccgacgaaat cagcgacccc ggtgcatgga tccgccgcac cgccgcctga cccagccgca
     8161 cgcccactct taccaaggac tcgcgagatg accacccaca acgaagcgca gccgtcgact
     8221 ccaaccggca tgatcaccct ggacggcctt gagaactggg tcgacgaggg actcattacg
     8281 actgtgctgc ccgtcctgcc ggacatgggc gggaacctgc gcggcaagcg cttggccgca
     8341 ggcaagttca tgcaggcagc ctcccagcca ggacgcccgg tggcggaggc atgcgcgtac
     8401 gtcctggcca cagacatcga tatgagcccc gcccaggact acgacctgac cagttggatg
     8461 gccgggtttc aggacatcgc cgcgatgccg gacctgggca cactgcgcgt cctgcgccac
     8521 cagtccggta ccgcgctcgt ccactgcgac gccgcccacc ccggcgggca gcccgtaccg
     8581 gtggcacccc ggcacctgct gcgtcagcag ctcgacgcgc tcaccagcga gcacggcgtc
     8641 gagctgcgcg cgggcctgga gaacgaagtg gtcctctacg acgcgaccac cctgcgcccg
     8701 gtcacccagc acaatctcga ctacgcgctg cagcaccccc gcgccctcac cgatttcttc
     8761 acccagctgg agcgggcgct ggccttctcc gccacgcccg cggagtccgt gaagaccgag
     8821 ggagcgcccg gccagatcga ggtggcgttc ccctacgggc cggccatgag ggcgtgcgac
     8881 gactacaccg tctacaagca cctgctgaag gagatagccg gcgagcacgg catgctgccc
     8941 accttcatgg ccgccccgca gacgggcacc gccagcggcc tccacgtgca cgtctccctc
     9001 tggcagggtg acgagccggc gttcgccgcc accggccctg cggagttgcc cgaggctatg
     9061 cggcacgcca tcgcgggact gctcgccgca ctccccgacc tcgcgccgct gtacgcgccg
     9121 aaccccaaca gctaccgccg gtaccagccg tactccttcg cacccacgca ctacacctgg
     9181 ggagtcgaca accggacctg cgcgatccgg gtcactggcc acggcgcggg cgcccacctg
     9241 gaggtacggc tgcccggcgc cgacgccaat ccctacctgg ctgtcgctgc cgtctgcgcg
     9301 ggcatcaact acggcctggc ccacaagatg gatccgcccg agccgtggac cggcgacggc
     9361 tatgaggccg aagcgggcaa gggagtagtg cccgtcccca gcagcctcac caccgcagcg
     9421 cgggccctgg aatcgagcag catcgccaac aagtacttcg gcagagacgt cgtcacgcac
     9481 tacgccacgg cggcatacca ggaggtcatg acgctgggcc ggcttgtgcc ggacacggag
     9541 atcaaccgct accgggaacg gatctgaccg accgggccgg gccgcgccca gatgccggtt
     9601 accggcccgg ccgccatgcc ctctcgcacc accggacagc cccacggcga catgggccaa
     9661 aaactcccgg accccgtctc agggcccggg ccgtgcacca tcaacgactg ccccaaggag
     9721 gcaccgcatg accatccagt tggagcgtcc gatcgcgccc acgcagcccg acgctgaggc
     9781 cgtccacgac gccaccgacc cgttcaacct cgacatcacc ttcatcgagg ggacgccggc
     9841 gaccgagaca gtcctgatgt gcagcaccgg cgacacctgc ggcagctcct gcccgagcgc
     9901 ctgcgtcacc tcgtaaaacc cgaggcaact cggcactgcg ggccggacgg ggctgacccg
     9961 gccggcccgc acacccccgc ctaccaagaa aggagtggtg atgacacgcg cacgacaccg
    10021 cctgtaccgg ggcaccgggc aagggatgct gcgcgcagca gtgagcgtcg atgagccggt
    10081 catggcgccg tggccggggc gctcggcctc gctcgacgac tggcgtgtgt ggctgggcac
    10141 cgtgtgggcc gacgagacct tccggcaggc cgtaggcagt gccagcccgg acctggccgg
    10201 ccaggtgcag gcgatcctcg gcggccgggc cccgaagctg cgccgcgtgc gccgggcggc
    10261 actggccacg gcccggtacg cgatccggta cgcgcgccgc tccactccgt acggcctctt
    10321 cgcgggcgtc gccatgatcg agttcgggga cacggcgaac atccgcttcg gggaccggca
    10381 ccaggccgtc acccgccccg atccggtggc actcgacgag gcgatcagcg cctgggaggc
    10441 ggacgccacc cggatgaccg atgtcgacgt gtgcgtccat ccccttgccc agcagcgcga
    10501 cggacatgtc tgcgtgccgt ccgagggcga cgccgagttc cgcctcgcgc tgagcagccc
    10561 cgcgctcagg ttcgtgctcg acgcagctca cgcccccatc cgctactccg tcttggcgga
    10621 caagctcgcc gccgagttcc ccaccaccgc cgaaggcgcc cgtatccagc tcctcggaga
    10681 gcttcttcgg gtacggctgc tgcggtcgtc gctgcgtgcc cccgccaccg tcgtcgaccc
    10741 cgccgaagcc ttaccgcccg ctctgcgcgc acaggtgcgc gatctcgcga cggttgccga
    10801 tctgcggctc gatgccacgg tgcaactgcc gcaggcagtc ctgaccgagg ctgagacggc
    10861 cgcgaccgtc ctggcccggc tcgccacgca cccaaacggc actccggcct ggtgccgctg
    10921 gatcgagcag ttcaccgacc gatacggcga gaacactgcg gttcccgtcg aggtggcgac
    10981 cgacgccgag cgaggcgtcg gcttcccgga cggcttcgtc aagatggtcg agccgccccg
    11041 cccgatgtcc cgccgcgacc ggctactgct ggagctggcc ggaaccgcgg ccgtcgccgg
    11101 cgcccgctcg gtgcccctga ccggcgcgat gatcgaggag ctggaggcgg tgggtgacaa
    11161 gccccgactc accgcaccgc acctcgaact ggccgcccag atccatgccc cctcggccga
    11221 ggcgctggaa cgcgggaact tccgacttca ggtggccacc gtttcccgct cggccggctc
    11281 gatgacgggg cggttctggc acctgctccc ggaagccggc gtcccgcaca cggccctgcc
    11341 cacgatggag cccggtgccg aggtggccca gctctccttc cacgcaggac gcgtaccggc
    11401 cgacctgctc acccgcgccc cgcgcgtgct gcctcggatc gtcagcgtcg gcgagttccg
    11461 ccaccccggt gacggtgtgc tgttccccgc cgacctggcg gtcagcgtcc gcgacggccg
    11521 cccgcgcctg gtggagatcg ccaccggcac ccacctggaa ctcctggcgc cgacagcgat
    11581 caacttcctc tggaacaact acacgccgcc gatggcccgc ttcctcggcg agatcagccg
    11641 ggccaccgca ccccaggtga cctggttcga ctggggcgtg gcctgggccc tgcccttcac
    11701 cccggcgctc acctaccgac ggtccgtcct cacggccgcg cgctggaagg tgcgcgcccg
    11761 ggatttaccc ggccggacca cggccttgaa ggagtgggcc gagcacctgc acgcctggcg
    11821 ggaccggttg cgggtgcccg accgggtgct gctggccgag gacgaccagc agctccccct
    11881 tgacctccat caggacatgc acctggatct gctgcgcgcc cacctggacg ccagccccat
    11941 cggcgttgcc accctgcacg aagcgccgcc ggccgacgcc gacaactgga tcggcggccg
    12001 ggctcacagc ctcgtcctcc ccctggtggc tcgcgcatga cggccacgac gctcccgccc
    12061 cgtacgcagg acctttccga gggccctctc gggatcgcgc tgctggacat cgagcgaggg
    12121 gacctgaccg ccgcgcggcg ccacctcgcg cagggcatcg cccacggcgt gagtaccggc
    12181 ggcaacgcga gcctgttcca cggagccccg gcgctggagt tcgtgctcgc ccgtgccgga
    12241 cacgccggtc ccgacatacg cgaggtcgtc gaccgcgtcg tggacgcacg cctggtcgca
    12301 gcacggcgac ggcagtcctc cggggcactg ccggacctca cggaatggga tcacatccgg
    12361 ggcctggcag gactgggcgc gctgctcttg acccgcccgg tgccctcgac gcggctgacg
    12421 gacgtgctgc tctacctcgt ctccctctcc cagccggtct actcccaggg gaagaggctg
    12481 cccgggtggt ggtccgcagt ggggccgggc ggcgaggaga tggccggcgg gcacagcaac
    12541 aacggcatgg cgcacggcat cgccggcccc ctgtcggtgc tctccctcgc cgcccgtcac
    12601 gacgtcctcg tgccgggcca gcacgaggcg atcgaggtct tcgcccgctg gctggaccgg
    12661 tacggcggcc actactggac cacccgcgcc cacctggacg ccgccgagcc gcccgagccg
    12721 gggcctgccc gtccgtcctg gtgctacggc cgacccggca tcgcccgcgc ccaacagctt
    12781 gccgcgctcg ccctgggcga ccgcgcccga cgccagagag cagaagacac cgtcgtacgc
    12841 acgctcaccg accccgctca cctcgcccgg atcaccgacg ccacgctgtg ccacggctgg
    12901 gcaggcctgg tgaccctcgc ccgcgccgtc gccgccgaca gccccgcccc cgaacgcttc
    12961 gcaccgctga tcaacgacct gcagcagcgc ctggccaccg acctggacca actgtccaag
    13021 cccggcttca tggagggccg cagcggtgcg cggctcgccc tcgacggcac gaacgccacg
    13081 aactggacca gcgtgctgct gatcacctga ccccgcaccg cccccgctga caaggaacgc
    13141 ccacgcgtat ggccttcgac gacgaaaacc taccgatcac acacgacacg acctggtggc
    13201 acgccagcgt cgccttcccc ggcggcgcgg tgagccccgc ggccgcccag gccctgtcgg
    13261 cagccctgca cgatcagcgc ttccacttcc tgcgcaagga tgcagggctg cgcctgcgca
    13321 ccgaacgccc ctgtgcggcc ctgctggacc gcctcgtcgc cgagcagcag atcaccggct
    13381 ggatccgcgg catctatgag ccggaaaccg aggccttcgg cggccccgag ggcatggacg
    13441 tggcgcacgc cgtgttctgc gccgacagcc gcagcgccct gcccgagacc ggcagctccg
    13501 gcacccgcga gcgctgcgtg atgctgctgt ccgtcatgat ccgcgaagcc ggcctggacc
    13561 ccttcgaggc cggggacgtc tggtcccagt tcgccgccct gcgcccttcc gtcgatccgc
    13621 ccgccgggcc cgcactcgac cgctccgtgg cggccatgcg gcggctggtg aacgccgacg
    13681 ccgcccggcg acccgacgcc gaaccgggct ggaccgaccg cgtcgccgcc ttcgcagacg
    13741 ccggccggcg tctgcgccgg ctcgccgccg atggacggct gatacgcggc ctgcgcgctg
    13801 tcctcgccca tcatgcgatc ttcgcgtgca atcgcgccgg catccctgtc gccgagcagg
    13861 ccgccaccgc atggctgggc cgtcaagtcg ccttctccac aacggctgat acccctgtgc
    13921 ctacccgctg gtccgcttcg ccggaccctg accttcctcg aatggagatc accgtgacac
    13981 ccgtcaccga ccccgtcgaa ctgcgcgcat ccctggcgaa ccgccttcag gagagcggcc
    14041 acctgcgcac ccccgccatc atcgacgcct tccgcaccac cgaccgtcac gagttcctcc
    14101 ccggcgtcga cctggagtcg gcgtacaagg aggacgcggt gcccatcaag cacgacgagc
    14161 acggcgagat gatctcctgc atctccgcgc cctccatcgt cgccactcag ctcgaacaac
    14221 tcgacgcccg gcccggccac accgtcctgg aggccggcgc cgccaccggc tacaacgcgc
    14281 acctgctggg caagctggtc ggcccctccg ggcaggtgtg gaccctggac gtcgaccagg
    14341 acctcgtcga cggcgcgaac aagaacctcg cccaggccgg ggccaccaac gtcaccgccg
    14401 tgctggccga cggagccgcc ggccttcccg aacacgcccc ctacgaccgc atccagttca
    14461 ccgtcggcgc gggcgacgtc cccgccaagc tcctcgacca gctggctccc ggcgggcgtc
    14521 tggtcctgcc catgcggatc cgcggcagca tcagccgcag tttcgccttc gagcgcgacg
    14581 gcgacacctg gaggaccgtc tcctgcgaga tgtgcacctt catccccctg cgcaagggcg
    14641 tctgcgacga catctacacc ctcgtgccca tggccggtga cggcaacgtc cgcttggaga
    14701 ccttcagcga gcaggaggtg gaccgcgacg cgctccgcac cgtcctggac acgccgcaga
    14761 ccaagatctt caccggcgtc aagctccgcc agggcgaccc cttcgagtgg ctgtacctgt
    14821 acctggcctg cgcgctgccc aatggcctgt cccgcatgcc cgggtcccgg cccggcttca
    14881 ccccgcactt cggctggggc tccatggccg ccctcgacgg cgactccctc gcctacctga
    14941 ccatccgcga aggcgcggac gacgccggcc gcttctggga gatcggcgtc atcggtcacg
    15001 gctcccacgg cgccgacctc gccgatcggt tcgtcaccga gatccgcacc tgggacgagg
    15061 gctggggcaa cacggccccg gaacccggct tccgcatggc cgtcggcgac gcccgcggcc
    15121 ggctgacggt cgccgacccg cgcttcgtca tcgacaaggc gcacagccga ctcgtcgtcg
    15181 actggccgcg caagggctga gccgatgatc cccgcgatag ccagccgcat ccccctggtc
    15241 aagcgcccca aggcgcccgc gctcccgctg gacgagcgca tcacccacct caccgggctg
    15301 accgtcgcgc ccgcaggcgc gagccaccac gaccgggtgg cccgcgcctg cggggtcctc
    15361 aactacgccg cgctgatcgc ctccgacgcc gggatgcccg ccctggcagc cgacctgtgc
    15421 tggcgacagc accggatctt cgccagcgcc aggcacctga cgggcgacat cgccgtcatg
    15481 tcgctgatgc ccctgatcaa catctcccgg ctgctgaccc gcgacggcga cggccacgcc
    15541 gcctacgacg tactcacccg cctctaccgc gccgcccagc aacgcggcac cgccgagatc
    15601 cacggccacg tgatcgacct cccggccctg atcagcacgg acgcggacca ccgcaagatc
    15661 tgccaggagt tgtgggtcgc cctgctcgtc gacggcgcac gcgccctggc acgcatcggc
    15721 tgctggacca aggccgccga agccatgacc gcacaccgcg gcatcggcca ccgtctcctc
    15781 gacggccgcc aaatcatgat catgtcgctg atggaacgcg gcctcgacga gcaggcgcgc
    15841 tccatggtcg agaccaccgc tttcacagag ccgtgggaga acgccgtcgc ggctcttctg
    15901 cgtgtccact gccggcccga cgtggccacc gcgccgcaac cagaagtgga cctcgctctc
    15961 caggaggcgg tcgcggtggt ggcccagccc gacgctgcgg ccgcggcatt ccaggcccgc
    16021 gtcgggctgg ccgcgctcga cctggtctgc gaccgcacca gccctcacgc ggctcacctg
    16081 tgcagtgcca tcgccgacgt ggcggttctc gacgcctatg ccgctcgcga cgtcctgcac
    16141 cgcgacgcgg aaggctcctg cctgtccgct gagcaaagac aggaactcaa cgccgtactc
    16201 accgctgccg ggctgggcac cggagagctc ccgccggccc atatgcaggc cctcgccgaa
    16261 gccgtggacg aggccgagcg agcacttcga gaccttctgt aagcccgccg gacggatctc
    16321 ggcgtttcgg ccaaccgcca ttcctgccag tcctgttgtg tggagcgggt cgatgcatcc
    16381 cgcacgctcc gccgcgtgct ctatctcggg actccgagag cgaccgaaac acatcagttc
    16441 gaaatcccgg cccggtcgtt gagcctcacg accacgccgg accactgtcc agggagaccc
    16501 cgcattgacc tcgaccgcca cgaacgagca gcagcacacc gcgccgcctc cgccgcctcc
    16561 cgcagagatc acctacagcg ggcagtactc cgtcaatccg ctcgccgagg tctccttccg
    16621 gcggatgtgc gcgcagatcc cggccgtcct gggccggatc gcccggctgt catggcgcac
    16681 cgaccggcgg gcggtgcagc tcctcctcgg ctgccaggtg gtcacgggcg tggccgccgc
    16741 cgtgctgctg gccgccaccg cccacgccat ggaacccgtc ctcggggacg gcaccgccgc
    16801 cgaccggctg cgcggcgccc tcccggcgct gctggtcgtg gcgctcgccg ccgcgctggg
    16861 ccgcggcgca ggggcggtgg ccacgtacgc cgagcggcgg atcaccccgc ggctgaccac
    16921 tcagacggac actgctgttg ttgaggcggt gtgccgggta gaggcagccg cgtacgcgga
    16981 ggacgggttt tcggaccggc acgaagctgc cgagatgggg gtgatccgca cgcacgtgat
    17041 ggtcaccgac gcccagcgct tcctgtccgc gctgatccgc atggtcaccg ccggcggagt
    17101 gctgtcggtg ctgaacccgt tgatgctgcc gctgctcctg ctcgccgtgc tgccggccgg
    17161 cgtcggcgcc gtcctgaccg cccgggtcga ctacgagatc cactacgcca acatcgccga
    17221 ccgcaacgtg cgcggcatga tgcgctggtg ggcgaccaca ccgaagtacg gcgacgaggt
    17281 ccgggccaac tcgatgaccg actacctcgt ctactggtac cgggccctgt ccgaccggtg
    17341 tgaccggcgc accgtggccg ccgcgccgcg gaccctgcgg atcgccctgc tgtccgcgct
    17401 ggccggcggc gtcttcctgg tggcgacctg gggcgcgttg gcgtggctgg cggtgtcggg
    17461 ccggatcgag ctcgcggtgg ccgcaacggc cgtcatcgcc gtgcagacca cgctcgccgc
    17521 gctctcccag gtcgtcgtgg gcggtgccgc ggtcttccac accagcctgt acctgggcga
    17581 catgcagtcc ttcctcgacg aggccgccgc ccgcgccccc cggcgcggcc cccgcaccca
    17641 cgccgcgccg accgaggaga tccggctcga ggaggtcgtc taccagtacc cgggcaagga
    17701 caagcccgcc gtcgacgggg tctccctcac cctgcggcgc ggccagatcc tcgcgatcgt
    17761 cggggcgaac ggctcgggca agtccaccct cacccgtctg ctgaccggga tctacctgcc
    17821 ggacaagggc aaggtcacct ggaacggcac cgacctcgcc gaggtcgacc ccgccacggt
    17881 atgggcgcac accggactgg tgccgcagat cttcgcgcag tggccgctgc gggtccgcga
    17941 aaacgtcacc ctcggccagc cgcgcaccca cgacgacgcc ccggtgtggg aggccatcga
    18001 cgcggtcggc ctgcgcgcag ccgtcgacga cctgcccgcg ggcctggaca ccctcctgtc
    18061 ccgcgacgtc ttcggcggct gtgagctctc cggcgggcaa tggcagcgcg tcgcctgctc
    18121 ccgggctctg taccggcgcc cggggctgct gatcctcgac gagcccacct cccagatgga
    18181 cccgcgcggc gagcaccaga tcttcgagca gatcaaggcc atcgccgccg accgcatcac
    18241 catcgtggtc acccaccgcc tggagaacac caagatcgcc gaccacatcg tcgtaatgga
    18301 gcacggccgg atcaccgaac agggccgcta cgacgacctc gtccacggcg gcggaacctt
    18361 cgccgagctg ctggagcttt cccaggaccg ctgaccgctt ccgccccacc cgtcccccat
    18421 ctgtctcccg cccgtcctgc cgcgcggcgg cacgggcacc accgaggagg agccgtgccc
    18481 ccatccctca ccgctgccga tggccgcgtc ccccgttcct tacgtgcttc acgcccgagc
    18541 gcgaggtgcg cggcgtgagc cagacgaaac ccctgcccgc gacggtgcgg cgctgggcgg
    18601 agcagcggat cggtcccgtc gtgaccgtac gcgacgcctc gcacgactgg gaccgctccc
    18661 gggtgtggga gctgcagggc gcaggcggcg cccgccgcta tgtgaaggtc tcgcccagcg
    18721 agaagttctt cacccgcgag acccgggcct accgccacgt cgtccccgcg ctcggcccca
    18781 gccgggcacc ccacctcgtc gacagccgtg cgcaggacct ggccctgctg ctcaccgcag
    18841 tgccaggcac cccggcgccg gggctcggcc tcacccccgg cgcgtggcgg gccgtgcacc
    18901 ggcaggccgg cgcgctgtgc gcccgcctcc acgaagccgg tgacctcgac cgcgccgacc
    18961 gggcggaggc cgaagcgtcc ctggaggccg ctgccgacgg agcggagaag cacctggccc
    19021 gcgccgggga ccggctcacc gcggacgagc agcagatgat ccgcgaccat gccgcccagc
    19081 tccgccgcgt cggcccggtg cccgtcggat acatccacgg cgacaaccag cccaggaact
    19141 ggctgtggtc cccggccggg ctcgccctcg tcgacttcga acgcacccgg ccggccgccc
    19201 gcgtccagga cctcgtcatc ctcaccgtca ccgagtggct cgaccacccc gaccgcgagc
    19261 aggcgttcct ccaggcatac gggcgcgcgc tcacccccgc cgaacggcac gcgctgcgct
    19321 gcctgaccgc gctggacgcg gtcaactgcc tggcctgggg cccggacaac aaccagccag
    19381 aggtcaccgc ccggggccga cggaccctgg accggctcat gagggagaac aggacttgag
    19441 cgacgtccac cggagcatcg cccacgtcat ggtgctgctc cagcgtccca gtgacgggcg
    19501 agtgctcacg gtacggcacc agccgcactc gtggcactcc cccggcctgc tgaccgtcgt
    19561 cggcggccgg ctcgaagccg gtgagttctt cgacgaagga gcggcgcgcg agctcgccga
    19621 ggaggtcggc atccgcatca ccccgaaccg gctcgagttc tgccagctcg cccacctcca
    19681 tgcctcggac ggagaacggg tggtgggcgc cgtgttcctc gcccgaagct gggagggcga
    19741 gccgtacaac cgggagccgc gcacccacag cgagctggtc tggatcgatc ccaccagccc
    19801 accggaggac tgccacccct tcacccacga gatcctgcgc cacttcaccg ccgggcaccg
    19861 gtacgccaac gtcgtcgccc cggaactggc ggccgggggt aaggccgggt gacggtcgcc
    19921 gtcctggccc cgcgggccac cgcccggacg acccccgcct accggtacct gctcggcggc
    19981 gaggccacga gtgaccaccg ggggtcgtac ccgtcgtcct gctactggct cccccatccg
    20041 cgctctgcgg aacatgccca ccccgcccgc ccgcgcgacc gtgccgcccg ctcgtgaagg
    20101 agcttcatga ccaccgagtc ccccgcagcc gcggcctact gggagcggct ctgggccgac
    20161 ggccgccgct accggcagct cggcgacacc gagatccggc tattggaaga tcatctccgc
    20221 cctggccgcg cccgccccgc cctcgacctc ggctgcggcg acggggccct ggcccgacac
    20281 cttgaacagc tcggctaccg cacgaccggc atcgactgct cccccagcgc cgtcgcgctc
    20341 gccgccgccg accaggacag cgggcccggc cacggcccgg tctggcggtg catggacatc
    20401 accaccgacg acctcaacgc cctgccggac cgggcatacg cggtcatcac ctcccgcctg
    20461 gtctaccggt ggatcgacga caaagcggcc ttcctcgacc gcgcccgccg cctcctcgcg
    20521 ccaggcgggc tcttctgggt ggtcaccgag atctccggcc ggcgcgccga caccgacccc
    20581 ctgcaacacc tcggaatcac ccccgccgaa gccgagatcc tcaccgcggg ctggtccgtc
    20641 gtccacaccg ccgacctcga cgtcctccgc tgctacgccc tgcgcccctg acccccgccc
    20701 cggcaaaccg atggagaacc tggtgaacac cgagacgcac accgtggaga cctggaacat
    20761 ctacggcgcc caccaactag cccggaagct acagctgccg gagctggacc gatgggactg
    20821 gggcatcccg gacaccggtc ccggcatcga agccctcggt gacgtgaagg ggctgcgcgt
    20881 gctcgacgtc ggcagcggcc tcggccggca cgccgcccac ctggccgccc tgggcgccga
    20941 ggtcaccgcc gtggacgcct cccccgccca gcaccagcgc gccctcgccc gctacccgga
    21001 caccccgggc ctgcacctgg tgtgcgccga cgccgtggcc cacctgcgcg atgccgaccc
    21061 gtacgacttg atctactcca tcggctcgat gccgtacctg aacccagacc gccttctgcc
    21121 cgccctggcc aacggcctca aaccgggcgg ccggctggtc ttcaccgcgc tgcacaccaa
    21181 ctcccacggc accggaccct cagccgaggt cacccggcgg cccgagatcc tgcggctgcc
    21241 cggcaccacc gaagaccacc cggtagacat gtgggtcctc acgccgcaac tgtgggaggg
    21301 cctcctgctc cagcacggcc tcaccatgga ctcggtcacg gcgatcgact ccccgaagcc
    21361 ggacaaccac ctctcctacc ggctgtacgc gggccgccgc ccgcagcacg taccgagcgg
    21421 cccccgcatc agcgcgccgc ctccgccgaa cacggcgctg ggatcgacgt gatcgtgcac
    21481 ggctcggacg gagtcctgct cgggtggcac cggcaccgta tgtggaagct cgccggcggg
    21541 accgtcgagc tgggcaggac cttcgcccag gccgccatcc gcgtactccg ggaaggaaca
    21601 ggtctcatgg cgagcccggc gacgtacagg tgctgggcac gctcctgaac cgggtgggcg
    21661 aacgtcgtcc gggtcacagt gcccgtccta agcgcctatc cagaagttcc gtcggtaact
    21721 ggtcgggaac caagggctgg tccagggggc gg
//
