LOCUS       NZ_BMVW01000003        22655 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000003
VERSION     NZ_BMVW01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 638423)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 528485
            Orig. end                         :: 551140
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22655
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22655
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22655
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12655](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12655
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    172..186
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.64"
                     /tool="antismash"
     misc_feature    257..272
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    609..623
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            complement(621..1889)
                     /locus_tag="IE242_RS12335"
                     /old_locus_tag="GCM10010365_25570"
     CDS             complement(621..1889)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:
                     extracellular ligand-binding receptor"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431749.1"
                     /locus_tag="IE242_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25570"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_189858325.1"
                     /transl_table=11
                     /translation="MRTTSAARAAAGALAALLVLSACSSKAEDGGGEGGKESTGGVRTG
                     DGVSGDTIKLGVLTDMTGVYATLGKSVTQAQQLYVKQLNAEGGVCGYKIELTVRDHGYD
                     PQKAVAAYTELEPDVLGFPQFLGSPFVAAVRQRIEGQDKGLVLPQAWAHSLLGSEYIRV
                     LGSTYDVETINAIDFLMQEKGIKKGDKIGHVYFEGDYGESAVEGSRHMAEEAGLTVVEQ
                     KIKPTDNDMTAQVAALKKAGVKAIVISAGPRQAASLVGVAAAGGFDVPIIGNNSAFSPQ
                     LLATQAGPALMKNYYVASPSLPIGADTEEAKKLVADYKAAYPEDSLDNGVVAGWTAAAV
                     FTEALEEACAKKDLTRDGVGKALLSLNSFDNGFGVANDFSDPKAPSSKESVILQPDKAV
                     TGGMKVVREPEASEAAQAYTPGA"
     gene            complement(1886..3040)
                     /locus_tag="IE242_RS12340"
                     /old_locus_tag="GCM10010365_25580"
     CDS             complement(1886..3040)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379655.1"
                     /locus_tag="IE242_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25580"
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="WP_189858327.1"
                     /transl_table=11
                     /translation="MSDVLATEKGTPGTPRTARSAPVRRLPGPRAWVWAALAVLLLALP
                     FYLDRFWLQAGLFAMAAAIGAIGINLLTGATGQLSMGHAFFLAVGAYGYCVLAGDGGGS
                     GGDGLVGLGLPTWLAAVLAVLLAGAAGGLFSPIAGRLRGAYLGIATLALIFIGQHVLFN
                     AQDLTGGFNGRDVPPLNLFGLTFDDSELVVAAVPFGSAEKLWYLGLALLLGGALFARGV
                     LRGRPGRAMNAIRDHRIAAGVMGVPVARYRAAVFVLSSMYAGLAGVLLALVFQRTVPDY
                     FGITLSLEYLAMIVIGGLGSVSGAVAGALFVSLLPQLLTRYSDALPLVSAPGTGGIAPG
                     EASRYLYGAAVVAVVLFLPGGLVRVAARLRSKLRHIPGDPVEER"
     gene            complement(3033..3923)
                     /locus_tag="IE242_RS12345"
                     /old_locus_tag="GCM10010365_25590"
     CDS             complement(3033..3923)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019765573.1"
                     /locus_tag="IE242_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25590"
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="WP_189858328.1"
                     /transl_table=11
                     /translation="MTTFAELLLNGISLGSVYALIALGFVVIFRATEVVNFAHASLLLA
                     GGYVTAVLHEDIGFWPALLVGIAGAAAVGAAVEFLVMRRYRGADHSVLAIVTIGVDILL
                     TTELTRRIGTDVLALGDPWGDAVLTLGPISLAHTRIAAFLAAGLLITAFLLTFRYTSWG
                     VAMRAAAESAETAALMGVRLGRVSLGAWAVAGGLAAVAALFLTVFPTPGLERATSLAAL
                     KAFPAAILGGLDSTTGALVGGLLIGITESLATGYQSDLAFLGRGLGDLAPYLVMIAVLL
                     VRPAGLFGTKELARV"
     gene            complement(3920..4735)
                     /locus_tag="IE242_RS12350"
                     /old_locus_tag="GCM10010365_25600"
     CDS             complement(3920..4735)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379660.1"
                     /locus_tag="IE242_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25600"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189858330.1"
                     /transl_table=11
                     /translation="MTSALPHTDLPSAGIPPLEVSDLTVRFAGLTALDSVTFTVRPGTV
                     HALIGPNGAGKSTCFNVLTGVYRATEGSVRLGEQELTGLPPHRIADLGVARIFQNLALP
                     PHATVEDSLLLGRHRLTRTGFLAAGLRLPSAAREDRRHRARVREIAEFVGIADCLGHPA
                     GSLPYGRQKLAELARALCMEPKVLLLDEPVAGMTADERRRTAAVIAGVRDSLGISIVLV
                     EHDMGVVMRLADSVTVLDFGRRIADGAPGDVQNDPAVIRAYLGEEATQQ"
     gene            complement(4744..5556)
                     /locus_tag="IE242_RS12355"
                     /old_locus_tag="GCM10010365_25610"
     CDS             complement(4744..5556)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431753.1"
                     /locus_tag="IE242_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25610"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_189858332.1"
                     /transl_table=11
                     /translation="MGGGGAGLVVRDLSVGYGPVRALREVSLEVPEGAVVTVLGGNGAG
                     KTTLLRAVSRTLAFHGGTVTGGTVSLGDRRLDGLPPDRVVAAGVCQVPEGRQVFARMTV
                     ADNLRAGTFGSSGGRTARAAALRRVHELFPVLAERAQQHAGLLSGGEQQMLAVGRALMA
                     APKVLLLDEPSLGLAPLMAERIADTVREINDQGTSVLLVEQNAAIALRLADRAYVLEVG
                     EVTLSGPADELAASDEVRRRYLGVVDEDAAADASSARGTLPALSRWEG"
     gene            5820..7016
                     /locus_tag="IE242_RS12360"
                     /old_locus_tag="GCM10010365_25620"
     CDS             5820..7016
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431754.1"
                     /locus_tag="IE242_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25620"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_189858334.1"
                     /transl_table=11
                     /translation="MGARRRRTGHDWKLLAESCAALLERVPELVDEHLRRLAEHSSVYG
                     RAIPYDQHWREAEDAIRIGIETISAAPDAPRRDLAYAEDTGRRRAQQGLPLELLVHAYR
                     SAGYLVWDALLEGPAAREPERLRALLRSATMVWSAVDAQAAAASEAYRATERELRQRTD
                     EQVQALLDALLEGHAAPGLAARAAAGLDLPEHGRYAVVVLRAERRETFHRPLRGAGFRF
                     VWRMRTDREVGVVALAEGQDLDGVARVLTERSSGPGGISPVVGGLAELGPARRLAELAL
                     RTCPPDAPEVVRLDRRMPTALVVSQPELADRLVADVLGALLELEPADRAVLLETLDVWL
                     ACEGSAGRAAGRLYCHRNTVFNRLRRLEQLTSRSLARPRDLIEMTLALDAYRLSGAAR"
     gene            complement(7080..8198)
                     /locus_tag="IE242_RS12365"
                     /old_locus_tag="GCM10010365_25630"
     CDS             complement(7080..8198)
                     /EC_number="2.7.1.31"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133362.1"
                     /locus_tag="IE242_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25630"
                     /product="glycerate kinase"
                     /protein_id="WP_189858336.1"
                     /transl_table=11
                     /translation="MLIAADKFKGSLTAVQVAERVTAGLRRAVPGLAVEALPVADGGDG
                     TVDAAVAAGFERREIQVAGPLGEPVTAAYALRGDTAVVEMAEASGLQRLPAGVLAPLTA
                     STYGSGELLRAALDAGAGTIVFGVGGSATTDGGAGMLAALGARFLDADGRPVGPGGGAL
                     RDLATADLSGLDPRLADVGFVLASDVDNPLTGPKGAPAVYGPQKGASPEDVAVLDEALA
                     HFAAVLEKAVGPKAAEYAGAPGAGAAGGIGYGALLLGARFRPGIEVMLDVLGFAPALER
                     ATLVITGEGSLDEQTLHGKAPAGVAAAARAAGKEVVAVCGRLALAPEALGGAGIRRAYP
                     LTDVEPDVQRCIAEAGPILEDVAERIARDFVG"
     misc_feature    8206..8222
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.23"
                     /tool="antismash"
     gene            complement(8317..8556)
                     /locus_tag="IE242_RS12370"
                     /old_locus_tag="GCM10010365_25640"
     CDS             complement(8317..8556)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_25640"
                     /product="hypothetical protein"
                     /protein_id="WP_189858338.1"
                     /transl_table=11
                     /translation="MNKLRRAIVLAVSSLTVLLPAASAHAKPPAPVVGAGDVSVLTGDF
                     DVLEDVMEHITMKRGNGPTAHQIYDHSRGGALPE"
     gene            8804..9892
                     /locus_tag="IE242_RS12375"
                     /old_locus_tag="GCM10010365_25650"
     CDS             8804..9892
                     /EC_number="3.2.2.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983358.1"
                     /locus_tag="IE242_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25650"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_189858339.1"
                     /transl_table=11
                     /translation="MTLVGTEFPDRVLGGWLGRIAGNMLGKPVERGDHWTRERIDRYLR
                     QAGALPLTDYLPEPVSESDGLALRPEWRACVRGRIHGSCRDDDVDYAILGLDLLETHGF
                     GFTTEQVGDLWLLRLPYLQTFTAERAAYRNLTTGLKPPLTATYDNPYQEWIGALIRADI
                     HGWTHPGDPRRAAASARRDAVLSHTGNGVYGAMWAAALIAAAFTAPAVRPALDTALTVI
                     PAGSRLARTVRRVLTLHEAGLGWEDTLDTLAGETAGLGWIHTVPNAAVLTAGLLYGAGD
                     FTRTVALTVRGGLDTDSNGATAGSVAGVLCGAGAIPPQWTDPLRDTVRSAVFGFDGVRI
                     SELAERTVRLVAHGPDAPGSNC"
     gene            10001..12655
                     /gene="uppS"
                     /locus_tag="IE242_RS12380"
                     /old_locus_tag="GCM10010365_25660"
     CDS             10001..12655
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894521.1"
                     /locus_tag="IE242_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25660"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_189858341.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.6e-26, bitscore:
                     88.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.4e-16,
                     bitscore: 55.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRWWRCARTAVWHAVLEQSRNRSALVLAVFFVPLWLCLAHLVLP
                     ADPVLFLLRAADRPVRLDANAVAELSGALHSLTLVVGFMMFLSTSRSAVFYRRLATAGC
                     PRSCLVPAQGSVLLMWAAPTAAYATAWVCFFRQPERVDVLAAALCVGALVYGAAGILLA
                     TLTRSELAGLFTVTVVGFVDLTLQNPVANSCADSPVVRLLPAYGAMQSAVSAVSTGGTP
                     WEHLLLGLWWAAVLSLAALVVFTARTGGRKAAPAARRPVPGGSARERSSGPGPADRSPG
                     GPARAYRLAGITDPEVRAGYEACRRLVRRSRRLDSAIVQLFPPGLRPLLWAMYGYGRTL
                     DGVADAPDDTPRRRAERVGAHSRALETDLRHGRSDDPVRAALVDAVWRWDLPADDLSVM
                     AAGHRLDAARETRLLTWEDWHAYWDGLSFPFGVSRLPALLSGPGMAFTAEDADALHRWS
                     DAHNLVDALRDLREDARQGFVQLPHAVLEEYAVTADDLRQPRSSERVTALVNALADRAD
                     AWLDQAACLGGQHPPAAAAWRTVVALQRLELNRMRRRPGRLRHRVRPGTAAPGRDRHPF
                     TTADRIRFHCLLLAGRLRVARAWRRARTAAATPPAVLPVPVPRAATADHPAARTGPLPP
                     APHPDGARPPRLPADRLPRHVAITMDGSGRWATERGLSRGDGHRAGGRALRDIVYGALE
                     IGLPYLSVYALSAGNRACATADSGTLLRVLRTGLDLRTEELWQRDVRLVWSGSADGLPA
                     GLVRDLDDTVHATRDRAGLTLNLCLNHGGRDEITRAVRALAAQAVRGELTPERITARHV
                     GRQLHRPELPDVDLLVRTAGEQRTSDFLTWQSVHAELVFLDTLWPDADRTHLWTAVRTY
                     TGRERRFGAGTGR"
     misc_feature    complement(12720..12740)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.63"
                     /tool="antismash"
     gene            12752..13297
                     /locus_tag="IE242_RS12385"
                     /old_locus_tag="GCM10010365_25670"
     CDS             12752..13297
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142980.1"
                     /locus_tag="IE242_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25670"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_189858343.1"
                     /transl_table=11
                     /translation="MTTSDTTTQNTPNTPQDFAAYIASLPRVLAGAAALFRDAEGRVLL
                     VEPNYREGWALPGGTVESDDGESPRQGARRETAEEIGLDVEPGRLLAVDWVTGAGRPPL
                     VAYLYDGGVLGEDDFKAIVLQEEELLSWRLVPREELTAYLPGSLGRRVLAALDVLAEGS
                     GTAELENGHRVGGHRVDG"
     gene            13339..14067
                     /locus_tag="IE242_RS12390"
                     /old_locus_tag="GCM10010365_25680"
     CDS             13339..14067
                     /EC_number="2.3.1.286"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009327708.1"
                     /locus_tag="IE242_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25680"
                     /product="Sir2 family NAD-dependent protein deacetylase"
                     /protein_id="WP_189858345.1"
                     /transl_table=11
                     /translation="MTTKPLVAILSGAGISTDSGIPDYRGPNGLWRRDPEAEKLVTYEY
                     YMGDPEIRRRSWRMRRENRTLKAEPNAAHRAVAGLERSGVPVRVITQNVDGLHQLAGMP
                     ARKVLELHGSSRSVVCTKCHARGPMEDALARVEAGEDDPPCLECGGVLKSATVMFGERL
                     DPVVLGEAVAVTKASQVFVAVGSSLQVQPAAGLAGVAADHGARLIIVNAEPTPYDDRAD
                     EVIREPIGTALPELLRRIAG"
     gene            complement(14152..14997)
                     /locus_tag="IE242_RS12395"
                     /old_locus_tag="GCM10010365_25690"
     CDS             complement(14152..14997)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976615.1"
                     /locus_tag="IE242_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25690"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_189858347.1"
                     /transl_table=11
                     /translation="MIVVTGATGNIGRTLVPRLVEAGEEVVAVSRRPQPAGLPGGVRHA
                     QADPGDSATMRPVLEGAHALFLLLGGELNSRGESPDALLEAAVDGGVERVVLLSSQINS
                     TRSEALSHTRLREYEAAVRASGAESVILRPGNFASNAFAWAESVRVQRAVFAPFGDVAL
                     PVVDPADIAEVAAAALREDGHAGRTYELTGPEVISPRQQAAVISGALGEDVTFVELTRE
                     DAHAHMARFMPEEVIDGTLDVLGAPLPAEQAISPDVERVLHRPARPFGEWVARNLPAFR
                     "
     gene            15078..15674
                     /locus_tag="IE242_RS12400"
                     /old_locus_tag="GCM10010365_25700"
     CDS             15078..15674
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179775.1"
                     /locus_tag="IE242_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25700"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_189858349.1"
                     /transl_table=11
                     /translation="MTDSAAKPRARASEKRRRLTAAAARVLHEQGVERTTLADIARAAD
                     VPVGNVYYYFKTKDELVRAALSEHSAHLDELTGELARLPDPRDRLKALINTWVDQRETA
                     ARHGCPTGTLAVELDKRADGTLDMEAGAVLRRLLDWAAGQFRELGLSAPDDLAVTLISG
                     YQGMSLLANALRDPEIMTREGARLLSWLDSLEPAA"
     gene            complement(15694..16206)
                     /locus_tag="IE242_RS12405"
                     /old_locus_tag="GCM10010365_25710"
     CDS             complement(15694..16206)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538119.1"
                     /locus_tag="IE242_RS12405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25710"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_189858351.1"
                     /transl_table=11
                     /translation="MLELAILGFLAEGPLHGYQLRHRIAHLSGHARPVSDGSLYPAINR
                     LVRAGLLDRRTEPGASAAQRHTLSLTGAGRRELLRRLRDADGLDISDSTRYFTVLAFLS
                     HLPDTADQHAVLRRRLAFLERPASFFHDGDRPLGAEDTGDPYRRGMLVVARATSRAERS
                     WLREVLA"
     gene            16280..16939
                     /locus_tag="IE242_RS12410"
                     /old_locus_tag="GCM10010365_25720"
     CDS             16280..16939
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974516.1"
                     /locus_tag="IE242_RS12410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25720"
                     /product="cysteine hydrolase family protein"
                     /protein_id="WP_189858353.1"
                     /transl_table=11
                     /translation="MAYTEEWVTARARDAYERGRASFDVRPERTALLVIDMQDEFVRPG
                     WSPYWVPAATRMAPRLRQLVAVCRTAAVPVIWTIFDDTHLGLDRPHALRFLPHGDTDWR
                     RPGPAEVWDGMGRRPDEVLIRKPSYGAFYDTPLDTVLRNLGRDTVIVTGTLTNYCCGTT
                     ARQAYERGYRVVFGSDVTATDDESRQEPELAVLRKGFALVLTAEEIAGRLAAAQKV"
     gene            complement(16953..17435)
                     /locus_tag="IE242_RS12415"
                     /old_locus_tag="GCM10010365_25730"
     CDS             complement(16953..17435)
                     /EC_number="2.1.1.63"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038800.1"
                     /locus_tag="IE242_RS12415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25730"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_189858355.1"
                     /transl_table=11
                     /translation="MKQHTVIDSPYGALTLVATDGVLSGLYMTDQRHRPPEETFGVPDD
                     TPFGEATEQLRAYFAGELKEFTLGLHLAGTPFQRTVWEELRRIPYGETRTYGELATTLG
                     NPKASRAVGLANGRNPIGIIVPCHRVVGADGGLTGYGGGLPRKRRLLDFEREAALF"
     gene            complement(17470..19014)
                     /locus_tag="IE242_RS12420"
                     /old_locus_tag="GCM10010365_25740"
     CDS             complement(17470..19014)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133376.1"
                     /locus_tag="IE242_RS12420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25740"
                     /product="AlkA N-terminal domain-containing protein"
                     /protein_id="WP_271208681.1"
                     /transl_table=11
                     /translation="MRNGMHTDVERCVRAVRSKDARFDGWFYTAVTTTRIYCRPSCPVV
                     PPKPENMTFHPSAASCQQAGFRACKRCRPDASPGSPEWNRRADLVARAMRLIGDGVVDR
                     EGVPGLARLLGYSTRQIERELRTELGAGPLALARAQRAQTARLLIETTALPMADIAFAA
                     GFASIRSFNDTVREVFALSPSELRARVGTRKRSPARANEAAGATEATGAAGAAGATPGA
                     LTLRLPFRAPLNPDNLFGHLAATAVPGVEEWRDGAYRRTLRLPYGHGIAALTPAPDHIA
                     CRLTLSDLRDLPVAIARCRRMLDLDADPVAVDDQLRTDPVLAPLVDKAPGRRVPRTVDE
                     AEFAVRAVLGQQVSTAAARTHAARLVMAHGEPIDDPEGGLTHLFPSPEALAALDPGTLA
                     MPRTRRTTFTTLVNRLADGTIHLGVESDWEETRTRLLALPGFGPWTVDVIAMRALGDPD
                     AFLPTDLGIRRAAKELGLPSTPAALTARAAAWRPWRAYAVQYLWATDSHPINFLPV"
     gene            complement(19124..21133)
                     /locus_tag="IE242_RS12425"
                     /old_locus_tag="GCM10010365_25750"
     CDS             complement(19124..21133)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042625 - ATPase-coupled ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114252.1"
                     /locus_tag="IE242_RS12425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25750"
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_189858504.1"
                     /transl_table=11
                     /translation="MVCRVSATLTTSASPSGASSRPPGTPAPRRRTRVLALPEARWALA
                     STLAFLLALPLDLTGASAWLYGPLYAIAYAAGGWEPALEGLRALREKTLDVDLLMIVAA
                     LGAAAIGQVLDGALLIVIFATSGALEALATARTADSVRGLLDLAPATATRVSPKGDGTE
                     ETEETVPTDRLAVGDVLLIRPGERIGADGRVLDGESEADQATITGEPLPVPKAPGDEVF
                     AGTLNGTGALRVRVERDPADSVIARIVTLVEEASQTKAPTQLFIEKIEQRYAVGVVAAT
                     LAVFAIPLAFGADLTSALLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAV
                     AMERLGEIDTAALDKTGTLTEGTPEVTAVRPHPGSGLGEDALLALAAAAEHPSEHPLAR
                     AVVAAARARGLRIAPAEDFTARPGRGVSATVEGRVVTVGRAGEDGAGPDPTAAVRADEV
                     PGTTVLVRVDGTPVGTLTLTDRLRPDAAPAVSALTAVTGTSPVLLTGDNRSAAAQVAAD
                     TGITDVRADLLPEDKVDAVRGLQGTGRKVLFAGDGVNDAPALASAHSGVAMGRAGSDLA
                     LETADAVVVRDELTAIPAVVRLSRAARRLVVQNLVIAGTCIAVLVVWDLVGHLPLPLGV
                     AGHEGSTVLVGLNGLRLLRESAWRKASSPGSLPR"
     gene            21191..21559
                     /locus_tag="IE242_RS12430"
                     /old_locus_tag="GCM10010365_25760"
     CDS             21191..21559
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999635.1"
                     /locus_tag="IE242_RS12430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_25760"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_189858357.1"
                     /transl_table=11
                     /translation="MGHGAAAREETARVRLDAANVAKVATTLQALSTPSRLLILARLRE
                     GPLPATELAAEVGMEQSACSHQLRLLRNLGLVVGERQGRSVVYALHDHHVAELLDQAVY
                     HVEHLRLGISDAPEGDGD"
     gene            complement(21596..22039)
                     /locus_tag="IE242_RS12435"
                     /old_locus_tag="GCM10010365_25770"
     CDS             complement(21596..22039)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_25770"
                     /product="hypothetical protein"
                     /protein_id="WP_189858528.1"
                     /transl_table=11
                     /translation="MTDGVLALGTAVLCASGCVWYLPAVADVRAGADRPRSQRSAAVAC
                     LITWGTLAAVGVLLLTPMPWTGTAATAAAGLAAAAAVRVRARLQRGREQREESRRWAAL
                     GTRAPAVPGPRRASRVFVACAVSGLFLTAMAAATVLLVVGPTA"
     misc_feature    22525..22539
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
ORIGIN
        1 gctggacaac ctctccgacc tgatcagctt cggcctggca ccggcgtact tcgtactggt
       61 gtacgggatg gtcgcggacg acgcccacca gcgggtggcg gcgctcgggg ccatcgtggt
      121 gctgctggcc gtggtgctga gactggcgcg gttctcctgc gtgacgatga aggacgggat
      181 gttccagggc atgccgtcgc cgttcggcgc gctgacggtc gtctcgatcg tgctgctgga
      241 gctgcccttc gtggcgacgc tgctggcgat cctgggcacg gcgtggctga tggtgagccg
      301 ggtggagtac ccgaagcccc gcggtccgct cgccgcggcg atgctctcct ggatcgtggt
      361 gtccatgggt ctcctggcgg cctgggcgtt cgacgccccc ggcggccagc tgctgctcca
      421 gaccggctgt gccctgcagc tggtgctggg cgcggtgatc ccgctgttcg ccacggcccg
      481 ccgggtgaac aacttccgcg acaaccggcg cgaggcacgt gcggcgcagc tgccgtaacg
      541 gcggacgaag cagtgagcaa cgggtgtggg cccgagcctg atggctcggg cccacacccg
      601 ttcttccgtg aggttcctgt tcaggcgccc ggcgtgtacg cctgtgccgc ctcggacgcc
      661 tccggctcgc ggacgacctt catgcctccc gtcacggcct tgtccggctg gaggatgacg
      721 ctctccttgg aggacggggc cttcgggtcg gagaagtcgt tcgcgacgcc gaagccgttg
      781 tcgaaggagt tcagcgagag cagggccttg ccgacgccgt cacgggtgag gtccttcttg
      841 gcgcaggctt cctccagggc ctcggtgaac accgccgccg ctgtccagcc ggcgacgacg
      901 ccgttgtcga gggagtcctc cgggtaggcc gccttgtagt cggcgacgag cttcttcgcc
      961 tcctcggtgt cggcgccgat gggcagcgag ggcgaggcga cgtagtagtt cttcatcagc
     1021 gccgggcccg cctgggtggc gaggagctgc ggcgagaagg cggagttgtt gccgatgatc
     1081 ggcacgtcga agccgccggc cgcggcgacg cccaccagcg aggcggcctg gcgcgggccc
     1141 gcgctgatca cgatggcctt gacgccggcc ttcttcaggg cggcgacctg ggcggtcatg
     1201 tcgttgtcgg tcggcttgat cttctgctcg acgaccgtga gcccggcctc ctccgccatg
     1261 tgccgggagc cctccacggc gctctcgccg tagtcgccct cgaagtacac gtgaccgatc
     1321 ttgtcgccct tcttgatgcc cttctcctgc atcaggaagt cgatggcgtt gatcgtctcg
     1381 acgtcgtacg tggagccgag gacccgtatg tactcgctgc cgagcagcga gtgggcccac
     1441 gcctgcggga gcaccagtcc cttgtcctgc ccctcgatac gctgccgcac ggcggcgacg
     1501 aacggcgagc cgaggaactg cgggaagccc agcacgtccg gctccagctc ggtgtacgcg
     1561 gcgacggcct tctgcgggtc gtaaccgtgg tcccgcaccg tgagctcgat cttgtagccg
     1621 cagacgccgc cctcggcgtt gagctgcttc acgtacagct gctgggcctg ggtgacgctc
     1681 ttgccgagcg tggcgtagac gccggtcatg tcggtgagca cacccagctt gatggtgtcg
     1741 cccgagacgc cgtccccggt ccgtacgccg ccggtgctct ccttcccgcc ctcgcctccg
     1801 ccgtcctcgg ccttcgagct gcacgcggac agcacgagca gtgccgcgag cgctccggcg
     1861 gccgctctgg ccgcggatgt cgtcctcatc gttcctccac tgggtcccct gggatgtgcc
     1921 tgagcttgga gcggagccgg gcggccaccc tgaccaggcc gcccggcagg aagagcacca
     1981 ccgcgacgac ggcggcgccg tacaggtacc gggacgcctc gcccggtgcg atcccgcccg
     2041 tgccgggggc ggagaccagg ggcagcgcgt cgctgtagcg ggtcaggagc tgcggcagca
     2101 gggagacgaa gagcgccccc gccaccgcgc cggacaccga gccgagccca ccgatgacga
     2161 tcatggcgag gtactcgagc gagagcgtga tgccgaagta gtcgggcacc gtccgctgga
     2221 acaccagcgc cagcagcacc cccgcgaggc ccgcgtacat cgacgacagc acgaagacgg
     2281 cggcccggta gcgggccacg ggcacgccca tcaccccagc ggcgatgcgg tggtcgcgga
     2341 tggcgttcat ggcccggccg ggccggcccc gcagcacccc gcgggcgaac agcgcgccgc
     2401 ccagcagcag cgccagcccg aggtaccaga gcttctcggc cgaaccgaac ggcacggcgg
     2461 ccacgaccag ctcgctgtcg tcgaaggtga ggccgaacag gttcagcggc gggacgtccc
     2521 ggccgttgaa gccgccggtc agatcctggg cgttgaacag cacgtgctgt ccgatgaaga
     2581 tcagcgcgag ggtggcgatg ccgagatacg cgccgcgcag ccgcccggcg atggggctga
     2641 agagcccgcc ggcggccccc gcgagcagca cggcgaggac ggcggcgagc caggtgggca
     2701 gcccgaggcc gacgagaccg tcgccgccgc tcccgccccc gtccccggcc agcacgcagt
     2761 agccgtacgc ccccaccgcc aggaagaagg cgtgccccat ggacagctgg cccgtcgctc
     2821 cggtgaggag gttgatgccg atcgccccga tcgcggccgc catcgcgaac agtccggcct
     2881 ggagccagaa gcggtcgagg tagaacggca gggcgaggag gaggacggcg agggccgccc
     2941 agacccaggc gcgggggccg gggagtctcc gtacgggcgc gctgcgggcc gtacggggtg
     3001 taccgggtgt gcccttctcg gtggccagga cgtcagacac gggccagctc cttcgtgccg
     3061 aacagcccgg cgggccggac gagcaggacg gcgatcatca cgaggtacgg ggcgaggtcg
     3121 ccgaggcccc ggccgaggaa ggcgaggtcg ctctggtagc cggtggccag cgactcggtg
     3181 atcccgatga ggaggccgcc gacgagggcg ccggtggtgg agtcgagccc gccgaggatc
     3241 gctgccggga aggccttgag cgcggccagc gaggtggccc gttccaggcc cggggtcggg
     3301 aagacggtca ggaacagggc ggcgacggcc gcgaggccgc ccgccacggc ccaggcgccg
     3361 agcgacaccc tgccgagccg tacgcccatc agcgcggccg tctccgcgct ctcggcggcg
     3421 gcccgcatcg ccacgcccca ggaggtgtag cggaaggtga gcaggaacgc ggtgatgagc
     3481 aggccggcgg ccaggaaggc ggcgatgcgc gtgtgtgcga gggagatcgg gccgagggtg
     3541 aggaccgcgt cgccccaggg gtcgccgagt gcgaggacgt ccgtgccgat gcggcgggtg
     3601 agctcggtgg tgagcaggat gtccacgccg atggtgacga tggcgaggac gctgtggtcg
     3661 gcgccccggt agcggcgcat gaccaggaac tccacggccg ccccgacggc cgcggcgccc
     3721 gcgatcccca cgagcagcgc gggccagaag ccgatgtcct cgtggaggac ggcggtgacg
     3781 tacccgccgg ccagcagcag ggaggcgtgg gcgaagttga cgacctcggt ggcgcggaag
     3841 atcaccacga agccgagggc gatgagggcg tagaccgagc ccagggagat gccgttgagg
     3901 aggagttcgg cgaaggtggt cactgctgcg tcgcctcctc acccaggtag gcgcggatga
     3961 cggcgggatc gttctgtacg tcgccggggg cgccgtccgc gatcctgcgt ccgaagtcca
     4021 ggacggtcac cgagtcggcg agtcgcatca ccactcccat gtcgtgttcc acgaggacga
     4081 tcgagatgcc gaggctgtcg cgcacgcccg cgatcacggc ggccgtacgg cgccgctcgt
     4141 cggcggtcat gcccgcgacg ggctcgtcga ggagcagcac ttttggctcc atgcacaagg
     4201 cgcgggcgag ttcggcgagc ttctgccgcc cgtacggcaa ggacccggcc gggtggccga
     4261 ggcagtccgc gatgccgacg aattcggcga tctcacggac gcgggcgcgg tgccggcggt
     4321 cctcgcgcgc ggcggagggc agccgcagcc ccgccgcgag gaagccggtg cgggtcagcc
     4381 ggtgccggcc gaggagcagg ctgtcctcga ccgtggcgtg cgggggcagc gccaggttct
     4441 ggaagatccg tgcgaccccc aggtccgcga tgcggtgcgg gggcagcccg gtcagctcct
     4501 gctcgccgag gcggacgctg ccctcggtgg cgcggtagac gccggtgagg acgttgaagc
     4561 aggtggactt gccggcgccg ttggggccga tgagggcgtg gacggtgccg gggcggacgg
     4621 tgaacgtgac gctgtcgagg gcggtgaggc ccgcgaaccg tacggtcagg tcgctgacct
     4681 ccagcggcgg gatgccggcg gagggaagat cggtgtgggg aagagccgat gtcatgtgtg
     4741 cggtcacccc tcccaccggg acagcgcggg cagggtgccc cgggcggagg acgcgtcggc
     4801 ggcggcgtcc tcgtcgacca caccgaggta gcggcggcgt acctcgtccg aggcggccag
     4861 ttcgtcggcg ggcccggaca gggtcacctc gccgacctcc aggacgtacg cgcggtcggc
     4921 gagccggagc gcgatcgcgg cgttctgctc gaccagcagc acggacgtgc cctggtcgtt
     4981 gatctcccgc acggtgtcgg cgatccgctc ggccatcagc ggggcgagcc cgagggacgg
     5041 ctcgtcgagg agcagcacct tcggggcggc catcagggcg cgcccgacgg cgagcatctg
     5101 ctgttcgccg ccggagagga ggcccgcgtg ctgctgggcg cgctctgcga ggacggggaa
     5161 gagctcgtgc acgcggcgca gggccgccgc ccgtgccgta cgccctccgg agctgccgaa
     5221 ggtgccggcg cgcaggttgt cggccacggt catccgcgcg aacacctgcc gcccctccgg
     5281 cacctggcac accccggcgg cgaccacgcg gtcgggcggc agcccgtcga gccgccggtc
     5341 cccgaggctc accgtgccgc cggtgaccgt gcccccgtgg aaggcgaggg tgcggctgac
     5401 ggcccgcaac agcgtcgtct tgcccgcgcc gttgccgccg agcaccgtca ccacggcccc
     5461 ctcgggcacc tccagcgaca cctcgcgcag cgcgcgtacg ggtccgtatc ccaccgagag
     5521 gtcccgtacg acgagacccg cgccgccacc gcccatgtgt ctccctgctc tcacccgaag
     5581 tgccgatgtg ccgatgtgcc gaagtgccga agtgccgaag tgccgatgtg cccggagccg
     5641 ttccgtgccg ttccgtgctt gtgtcgcgct cacgacagca ccgccgtgtc gggcccgtcc
     5701 acgggccggt gcggaatcgc tgcgggtgac cagcgggccc gcccgcgcgt tgtgcgcgcg
     5761 cacaacaccg cgtgtcaggg gcctgcgcgg cgcggtgacc cgatggcatc ctccgggcca
     5821 tgggagcgcg cagaaggcgt accggccatg actggaagct gctcgcggag tcctgcgcgg
     5881 cgctgctgga gcgggtgccc gagctcgtcg acgagcacct gcgacggctc gccgagcact
     5941 cctccgtcta cgggcgggcg atcccgtacg accagcactg gcgggaggcc gaggacgcga
     6001 tacggatcgg catcgagacg atctcggcgg ccccggacgc accgcgccgc gatctcgcgt
     6061 acgcggagga caccggccgt cgccgggccc agcaggggct gcccctggaa ctgctggtgc
     6121 acgcctaccg cagtgcgggc tacctggtct gggacgcgct gctggagggg ccggccgccc
     6181 gggagccgga gcggctgcgg gccctgctgc ggtcggccac catggtgtgg tcggcggtgg
     6241 acgcgcaggc cgcggcggcg tcggaggcgt accgggcgac cgagcgggaa ctgcggcagc
     6301 gcaccgacga gcaggtgcag gcgctgctgg acgccctgct ggaggggcac gccgcgccgg
     6361 ggctcgcggc gcgggcggcg gcgggcctgg acctgccgga gcacgggcgg tacgcggtgg
     6421 tggtgctgcg cgcggaacgc cgggagacct tccaccggcc gctgcggggc gccgggttcc
     6481 gcttcgtctg gcggatgcgc acggaccgcg aggtcggcgt ggtggcgctg gccgaggggc
     6541 aggacctcga cggggtggcc cgggtgctga cggagcgctc ctccgggccc ggcgggatca
     6601 gccccgtggt gggcggcctc gccgaactcg gcccggcccg gcggctggcc gagctggcgc
     6661 tgcgcacctg cccgccggac gcgccggagg tcgtacggct ggaccggcgg atgcccacgg
     6721 ccctggtggt gagccagccg gagctggcgg accggctggt ggcggacgtc ctcggggcgc
     6781 tgctggagct ggagccggcg gaccgggcgg tactgctgga gaccctggac gtgtggctgg
     6841 cctgcgaggg gtcggcgggg cgggccgcgg gacggctgta ctgccaccgc aacacggtct
     6901 tcaaccggct gcggcgcctg gaacagctga cgtcgcggtc gctggcgcgg ccccgggacc
     6961 tgatcgagat gacgctggcg ctggacgcgt accggctgtc gggggcggcg cggtgaggga
     7021 ggcgctccct caccgcttcc gcccgtacgt ccgcctgtcc cgggcgggcg aggaccgggt
     7081 cagcccacga agtcccgcgc gatccgctcc gccacgtcct ccaggatcgg ccccgcctcc
     7141 gcgatgcacc gctggacgtc cggctcgacg tcggtgagcg ggtaggcgcg gcggataccg
     7201 gccccgccga gcgcctccgg cgccagcgcg aggcgcccgc agaccgcgac gacctccttg
     7261 cctgcggcgc gcgcggcggc ggcgacaccc gcgggcgcct tgccgtgcag ggtctgctcg
     7321 tcgagggagc cctcgccggt gatcaccagg gtggcccgtt ccagcgcggg cgcgaagccc
     7381 agcacgtcga gcatgacctc gatgccgggc cggaagcggg cgccgaggag gagcgccccg
     7441 tacccgatcc cgccggcggc accggcgccg ggcgcgccgg cgtactcggc ggccttcggg
     7501 ccgaccgctt tctccaggac cgccgcgaag tgggccagcg cctcgtcgag caccgccacg
     7561 tcctcggggc tcgccccctt ctgcggcccg tacacggcgg gcgcgccctt ggggccggtc
     7621 agcgggttgt cgacgtcgct cgcgagtacg aacccgacgt cggcgaggcg ggggtcgagc
     7681 ccggacagat cggcggtcgc caggtcgcgc agcgccccgc ccccgggccc gacgggccgt
     7741 ccgtccgcgt ccaggaagcg cgccccgagc gcggcgagca tgccggcgcc gccgtcggtg
     7801 gtggcgctgc cgcccacgcc gaacacgatg gtgccggctc cggcgtccag cgcggcgcgc
     7861 agcagttcgc ccgatccgta cgtcgacgcg gtgagcgggg cgaggacccc ggcgggcagc
     7921 cgctggagcc cgctggcctc ggccatctcc accacggccg tgtcgccgcg cagggcgtac
     7981 gccgccgtga cgggctcgcc gagcggcccc gcgacctgga tctcgcgccg ctcgaacccg
     8041 gcggcgaccg ccgcgtccac ggttccgtcg ccgccgtcgg ccacgggcag cgcctcgacg
     8101 gcgagcccgg ggacggcccg gcgcagtccc gcggtcaccc tctcggcgac ctggacggcg
     8161 gtcagcgaac ccttgaactt gtcagcggcg atcagcacgc gcaccttgca ttcccctcgc
     8221 tactcgggcc ttgcacatgt caaggcagtc gcgccgctgt gaccttaacc ggaggagggc
     8281 accgctgccc agggtggacg tccctcgacc ggagactcac tccgggagtg ccccgccccg
     8341 ggagtggtcg tagatctggt gtgccgtggg gccgttgccg cgcttcatgg tgatgtgctc
     8401 catcacatcc tcgaggacgt cgaagtcccc ggtcaggacg ctcacgtcgc cggccccgac
     8461 gacgggcgcg gggggcttgg cgtgggcgga ggcggcgggg aggaggacgg tgagggacga
     8521 gacggcgagc acgatcgcac ggcgcagctt gttcatgacg ctcctgaggg gagtgcgtgc
     8581 agtttccggc ggcgtcgcgg tgatcggcgg ccggccggaa ccaagcggac gaccggcagt
     8641 aaaccagacg aacatctcat gctgttgtgg aaagggacga aagttaaccc ggaagtggcc
     8701 accgggttga cgcggatacg aaagcggagt tgacgcgcgc ggagcccgcg ctgagtcgcc
     8761 ccgcagccgc cccggatccg gcacgccggt gtacaccgga ggtatgaccc ttgtgggcac
     8821 cgagttcccc gaccgcgtcc tcgggggctg gctgggccgg atcgcgggca acatgctcgg
     8881 caaaccggtc gagcggggcg accactggac gcgggagcgc atcgaccgct atctgcggca
     8941 ggccggcgcc ctgccgctca ccgactacct cccggagccc gtcagtgaga gcgacgggct
     9001 cgcgctgcgc ccggagtggc gcgcctgcgt ccgcggccgg atccacggca gctgccgcga
     9061 cgacgacgtg gactacgcga tcctcggcct ggacctcctg gagacgcacg gcttcggctt
     9121 caccaccgag caggtcggcg acctgtggct gctgcggctg ccgtatctgc agacgttcac
     9181 ggcggagcgg gccgcgtacc gcaatctcac caccggcctg aaaccgccgc tcaccgccac
     9241 gtacgacaac ccgtaccagg agtggatcgg tgccctcatc cgcgccgaca tccatggctg
     9301 gacgcacccg ggcgaccccc gccgcgcggc cgcgtcggcg cgccgggacg cggtgctctc
     9361 gcacaccggg aacggcgtgt acggcgcgat gtgggcggcg gccctgatcg cggccgcgtt
     9421 caccgcgccc gccgtgcgcc ccgccctcga cacggccctc acggtgatcc cggcgggcag
     9481 ccgcctcgcc cgcaccgtgc gccgggtgct caccctccac gaggccgggc tcggctggga
     9541 ggacaccctg gacacgctgg ccggggagac cgccgggctc ggctggatcc acacggtccc
     9601 gaacgccgcg gtcctcacgg cgggcctgct gtacggcgcc ggggacttca ccaggacggt
     9661 cgccctcacc gtacgcggcg ggctcgacac cgactccaac ggcgcgaccg cgggctcggt
     9721 ggccggcgtg ctgtgcggag ccggggcgat cccgccccag tggacggatc ccctgcggga
     9781 cacggtgcgc agcgcggtct tcgggttcga cggggtgcgg atcagcgaac tggcggaacg
     9841 gacggtgcgg ctggtggcgc acggtccgga cgcgccgggt tcgaactgct gactggtcgc
     9901 tgtttcgagc ggtcgtcgcg ggcaccgcga caccgccggg tccgtacctc gttggccatg
     9961 ccgtgaagga cctcgttggg gatcccgcgg aggccgcggg atgagccgct ggtggcgatg
    10021 tgcccgtacg gccgtctggc acgcggtgct ggagcagtcg cgcaaccgtt cggcgctggt
    10081 gctggcggtg ttcttcgtgc cgttgtggct gtgcctcgcc catctggtgc tgcccgcgga
    10141 tccggtgctg ttcctgctgc gtgcggcgga ccggccggtg cggctcgacg cgaacgcggt
    10201 cgccgaactg tcgggggccc tgcactcgct caccctggtc gtcggtttca tgatgttcct
    10261 gtccaccagc cggtccgcgg tcttctaccg ccggctggcc acggccggct gtccgcgctc
    10321 ctgcctggtg ccggcgcagg gctccgtgct gctgatgtgg gccgcgccga ccgccgcgta
    10381 cgccaccgcg tgggtgtgct tcttccggca gccggagcgg gtcgacgtcc tggcggccgc
    10441 cctctgcgtc ggcgccctcg tctacggcgc ggccggcatc ctgctggcca cgctcacccg
    10501 cagcgaactc gcgggcctgt tcacggtcac cgtggtcggc ttcgtcgacc tgaccctgca
    10561 gaacccggtc gccaactcct gcgcggacag tcccgtggtg cgcctgctgc cggcgtacgg
    10621 cgcgatgcag tccgccgtct ccgccgtcag caccggcggc accccgtggg agcacctgct
    10681 gctggggctg tggtgggcgg ccgtgctgtc cctggccgct ctcgtcgtct tcacggcgcg
    10741 taccggcggc cggaaggcag caccggccgc gcgacggccg gtccccggcg ggtctgcgcg
    10801 ggaacgttcg tccggccccg ggcctgcgga ccgttcgccc ggcggcccgg cgcgggcgta
    10861 ccggctggcc gggatcaccg atccggaggt gcgcgccggg tacgaggcct gccgtcggct
    10921 ggtgcggcgc tcccgccgtc tggacagcgc gatcgtgcag ctcttcccgc ccggactgcg
    10981 gccgctgctg tgggcgatgt acggctacgg gcgcactctc gacggcgtcg cggacgcccc
    11041 ggacgacaca ccgcggcggc gggcggagcg ggtgggcgcc cacagccgcg ccctggagac
    11101 cgacctgcgg cacggccgca gcgacgaccc ggtgcgcgcg gcgctggtcg acgcggtctg
    11161 gcgctgggac ctgcccgccg acgacctgtc ggtcatggcc gccgggcacc ggctggacgc
    11221 ggcgcgcgag acccgcctgc tcacctggga ggactggcac gcgtactggg acgggctgtc
    11281 gttcccgttc ggcgtctccc ggctgccggc cctgctcagc ggcccgggca tggccttcac
    11341 cgcggaggac gccgacgcgc tgcaccgctg gagcgacgcg cacaacctcg tcgacgccct
    11401 gcgcgacctg cgggaggacg cccggcaggg cttcgtccag ctgccgcacg ccgtcctgga
    11461 ggagtacgcg gtcaccgccg acgacctgcg gcagccccgg tccagcgagc gtgtcaccgc
    11521 cctggtgaac gccctggcgg accgggccga cgcatggctg gaccaggccg cgtgcctcgg
    11581 ggggcagcat ccgcccgcgg cggcggcctg gcgcacggtc gtggcgctgc aacggctcga
    11641 actgaaccgg atgcggcgcc gtccgggacg gctgcggcac cgcgtccggc cgggcacggc
    11701 cgccccgggc cgggaccgcc acccgttcac cacggcggac cggatccgct tccactgtct
    11761 tctgctggcg ggccggctgc gcgtcgcccg cgcctggcga cgcgcgcgga cggcggccgc
    11821 cacaccgccc gccgtgctgc cggtccccgt gccccgggcc gccaccgcgg accaccccgc
    11881 cgcccggacc ggcccgctgc cgcccgcgcc gcacccggac ggtgcccgcc cgccgcggct
    11941 gcccgccgac cggctgcccc ggcatgtggc gatcaccatg gacggcagcg gacggtgggc
    12001 caccgaacgc ggtctgtccc gcggcgacgg gcaccgcgcc ggcggccggg ccctgcgcga
    12061 catcgtgtac ggcgcgctgg agatcggcct gccgtacctg agcgtgtacg cgctgtccgc
    12121 cgggaaccgg gcctgcgcca cggcggactc cggcaccctg ctgcgtgtgc tccgcaccgg
    12181 gctggacctg cggacggagg agctctggca gcgcgacgtg cggctggtgt ggtccggttc
    12241 ggccgacgga ctccccgccg gcctggtccg ggacctcgac gacacggtgc acgccacccg
    12301 ggaccgcgcc ggcctcaccc tcaacctctg cctcaaccac ggcggacgcg acgagatcac
    12361 ccgggcggtc cgcgccctgg ccgcgcaggc cgtacgcggt gagctcaccc ccgagcgcat
    12421 caccgcgcgc catgtgggcc gccagctgca ccggcccgag ctgcccgacg tggacctcct
    12481 ggtgcgtacg gccggggaac agcgcacctc cgacttcctc acctggcagt ccgtccacgc
    12541 cgaactcgtc ttcctggaca ccctctggcc cgacgccgac cgcacgcacc tgtggacggc
    12601 cgtgcgcacg tacaccggcc gggaacgccg cttcggggcc gggaccggcc ggtgactccg
    12661 gcggcgggtc ggcgccggtg actccggcgc cgggtccggc cggtgaggag gaaggacgca
    12721 agtcgtcacc gtggctggat acccttcctg gatgacgacc tcggacacca ccacgcagaa
    12781 caccccgaac accccccagg acttcgccgc gtacatcgcg agccttcccc gtgtgctcgc
    12841 cggtgccgcc gcgctcttcc gtgacgccga gggccgggtg ctgctcgtcg agccgaacta
    12901 ccgggagggc tgggcgctgc cgggcggcac ggtggagtcg gacgacgggg agagcccgcg
    12961 gcagggggcg cgccgcgaga ccgccgagga gatcgggctc gacgtcgagc cgggccggct
    13021 gctcgcggtg gactgggtga ccggagccgg gcgcccgccg ctggtggcgt acctgtacga
    13081 cggcggggtg ctcggcgagg acgacttcaa ggcgatcgtc ctgcaggagg aggaactgct
    13141 gtcctggcgg ctcgtgcccc gcgaggagct gaccgcgtac ctgccgggct cgctcggccg
    13201 ccgggtgctg gccgcgctcg atgtcctggc ggagggctcg gggacggcgg agctggagaa
    13261 cgggcaccgg gtgggcggcc accgggtgga cggataaccg ttcgccgggc ccttccggtc
    13321 ccccctaccc tcgaccccat gaccaccaag cccctcgtcg ccatcctcag cggggccggc
    13381 atcagcaccg actccggcat ccccgactac cgcggcccga acggactgtg gcgccgcgac
    13441 ccggaggccg agaagctcgt cacctacgag tactacatgg gcgacccgga gatccggcgc
    13501 cgttcgtggc ggatgcggcg ggagaaccgg acgctgaaag ccgagccgaa cgccgcgcac
    13561 cgggcggtgg ccgggctgga gcgctccgga gtgccggtca gggtgatcac gcagaacgtg
    13621 gacggtctgc accagctcgc cgggatgccc gcccgcaagg tgctcgaact gcacggcagc
    13681 tcgcggagcg tggtgtgcac gaagtgccac gcgcgcgggc cgatggagga cgcgctcgcc
    13741 cgggtggagg ccggcgagga cgacccgccg tgcctggagt gcggcggcgt cctgaagtcg
    13801 gcgacggtga tgttcggcga gcggctcgac ccggtcgtcc tcggcgaggc ggtggccgtc
    13861 accaaggcga gccaggtgtt cgtcgcggtc ggcagcagcc tccaggtgca gcccgccgcg
    13921 ggtctcgccg gcgtggccgc cgaccacgga gcacggctga tcatcgtcaa cgccgagccg
    13981 acgccgtacg acgaccgcgc cgacgaggtg atccgggaac cgatcgggac ggcgctgccg
    14041 gaactgttgc gccggatcgc cggctgacgg ccggctcggc gcccgccggc cgacgtaccg
    14101 acgccatgcc ctgttccggg cgcgccgcct gccgcgcgcc cggaacaggt gtcaccggaa
    14161 cgccggcagg ttgcgcgcca cccactcccc gaagggcctg gccgggcggt ggaggacgcg
    14221 ctccacgtcg gggctgatcg cctgctcggc cgggagcggg gccccgagga cgtccagggt
    14281 gccgtcgatg acctcctccg gcatgaaccg cgccatgtgg gcatgcgcgt cctcgcgcgt
    14341 cagctccacg aacgtcacgt cctcccccag ggccccggag atcaccgcgg cctgctgccg
    14401 cggactgatc acctccgggc cggtgagctc gtacgtacgt cccgcgtggc cgtcctcgcg
    14461 cagcgcggcc gcggcgacct cggcgatgtc cgcggggtcg acgacgggca gcgccacgtc
    14521 accgaacggg gcgaagaccg cccgctgcac gcggaccgac tcggcccagg cgaaagcgtt
    14581 cgaggcgaag ttgccggggc gcaggatcac ggactccgct cccgacgcgc gcacggccgc
    14641 ctcgtactcc cgcaggcggg tgtgcgagag cgcctcggag cgggtggagt tgatctgcga
    14701 ggagagcagg acgacccgct cgaccccgcc gtccacggcc gcctccagca gggcgtccgg
    14761 gctttccccg cggctgttga gctcgccgcc cagcaggagg aacaaggcgt gggcgccttc
    14821 gaggaccggt cgcatggtcg cggagtcgcc ggggtcggcc tgtgcgtggc gcacgccgcc
    14881 cgggaggccc gcgggctgcg gacgcctcga cacggccacg acctcctccc ccgcctcgac
    14941 cagccgaggc accagcgtcc gtccgatgtt gccggtcgca cccgtcacta cgatcattgc
    15001 cactccccag tgagttagtc agctgactaa aaaggaccgt agcatgcgtc ccacacccgt
    15061 tgtctatagt gagttgggtg actgactcag cagcgaagcc gcgggcccgc gcatccgaga
    15121 agcgccgacg gctgacggcg gcggcggccc gtgtcctgca cgagcagggc gtcgagcgga
    15181 ccaccctcgc cgacatcgcg cgcgcggccg acgtccccgt cgggaacgtc tactactact
    15241 tcaagaccaa ggacgagctg gtccgggcgg ccctgtccga gcacagcgcc cacctggacg
    15301 agctcacggg cgaactggcc cggttgcccg acccgcgcga ccgcctcaag gccctgatca
    15361 acacatgggt cgaccagcgc gagaccgccg cccgccacgg ctgccccacc ggcaccctgg
    15421 ccgtcgaact cgacaagcgc gcggacggca ccttggacat ggaggcgggt gcggtgctcc
    15481 ggcgactgct ggactgggcc gcgggccagt tccgcgagct gggcctgtcc gccccggacg
    15541 acctcgccgt caccctgatc tccggctacc agggcatgtc gctcctggcc aacgccctgc
    15601 gcgacccgga gatcatgacg cgcgaggggg cccggctgct gagctggctc gactccctcg
    15661 agcctgccgc ctgacgtctc caccggcgcg ctgtcaggcc aggacctcgc gcagccagga
    15721 ccgttccgcg cggctggtgg cgcgggcgac gacgagcatg ccgcggcggt agggatcgcc
    15781 ggtgtcctcg gcgcccagcg ggcggtcacc gtcgtggaag aagctcgcgg gccgctccag
    15841 gaacgccagc cgccggcgca gcaccgcgtg ctggtccgcg gtgtccggga ggtgggagag
    15901 gaacgccagc accgtgaagt accgggtgct gtcgctgatg tccaggccgt cggcgtcccg
    15961 cagccggcgc agcagctcgc ggcggccggc gccggtcagg ctcagggtgt gccgctgggc
    16021 cgccgaggcg cccggttcgg tgcgccggtc cagcagcccg gcgcggacca gcctgttgat
    16081 cgccgggtag aggctgccgt cactgaccgg ccgggcatgg ccggacaagt gcgcgatccg
    16141 gtggcgcagt tggtagccgt gcagcggccc ctcggccagg aatcccagga tcgcgagttc
    16201 gagcatgctg ctactctcgc acatcgaaac gaggtacctc gaatcgatgt agagggcggg
    16261 gatgacgggg atgacgggga tggcgtacac cgaggaatgg gtgaccgcgc gggcgcgcga
    16321 cgcctacgag cgcggccggg cctcgttcga cgtacggccc gagcggacgg cgctgctggt
    16381 catcgacatg caggacgagt tcgtccggcc cggctggagc ccctactggg tgcccgccgc
    16441 cacccggatg gcaccccggc tccggcagtt ggtcgcagtc tgccggaccg ccgccgtccc
    16501 ggtgatctgg accatcttcg acgacaccca tctcggactg gaccgcccgc acgccctgcg
    16561 gttcctgccg cacggtgaca ccgactggcg ccggccgggc cccgccgagg tgtgggacgg
    16621 gatgggccgc cgccccgacg aggtcctgat ccgcaagccc tcctacgggg cgttctacga
    16681 caccccgctc gacaccgtgc tgcgcaacct cggccgggac acggtgatcg tcacgggaac
    16741 gctcaccaac tactgctgcg gcaccacggc ccggcaggcg tacgagcgcg gctaccgggt
    16801 cgtcttcggg tccgacgtca cggccaccga cgacgagtcc cggcaggaac cggaactcgc
    16861 cgtcctgcgc aagggcttcg ccctcgtgct gaccgccgag gagatcgccg gccgactggc
    16921 cgcggcccag aaggtctagt ggcccaggag ctctagaaga gcgccgcctc ccgttcgaag
    16981 tccaacagcc gccgcttgcg gggcagaccg ccgccgtagc ccgtcaggcc gccgtccgcg
    17041 ccgacgacac ggtggcaggg gacgatgatg ccgatcgggt tgcggccgtt ggccaggccc
    17101 accgcgcggg aggctttcgg gttgccgagg gtggtggcca gttccccgta cgtgcgggtc
    17161 tcgccgtagg ggatgcggcg gagttcctcc cagaccgtgc gctggaacgg tgttccggcg
    17221 aggtggaggc cgagggtgaa ctccttcagc tctcccgcga agtaggcgcg gagctgctcc
    17281 gtggcctcgc cgaagggtgt gtcgtccggg acgccgaagg tctcctccgg cgggcggtgg
    17341 cgctggtcgg tcatgtagag gccggacagg acgccgtccg tggcgacgag ggtgagggca
    17401 ccgtaggggc tgtcgatgac ggtgtgctgc ttcatggtgt gtccttcgag cattcctgta
    17461 cgagcattcc tatacgggaa ggaagttgat cgggtggctg tccgtcgccc acaggtactg
    17521 caccgcgtac gcccgccacg gccgccaggc cgccgcgcgt gcggtgagcg ccgccggcgt
    17581 cgacggcagg cccagttcct tcgcggcgcg gcggatgccg aggtcggtgg ggaggaaggc
    17641 gtcggggtcg ccgagggcgc gcatcgcgat gacgtccacc gtccaggggc cgaagccggg
    17701 gagggcgagg agccgggtcc gtgtctcctc ccagtcgctc tcgacaccca ggtggatcgt
    17761 gccgtcggcc agtcggttca ccagggtggt gaaggtggtg cggcgcgtgc ggggcatggc
    17821 cagggtcccg gggtcgagcg ccgcgagcgc ctccggggac gggaacagat gggtgagacc
    17881 gccctcgggg tcgtcgatcg gttcgccgtg ggccatgacc aggcgggccg cgtgggtgcg
    17941 ggcggcggcc gtggagacct gctgtccgag cacggcccgt acggcgaact cggcctcgtc
    18001 gaccgtgcgc ggcacccggc ggcccggcgc cttgtcgacc agcggcgcca gtaccgggtc
    18061 ggtgcgcaac tggtcgtcca ccgctaccgg atcggcgtcc aggtcgagca tgcggcggca
    18121 gcgggcgatc gccacgggca ggtcgcgcag gtcgctgagg gtgaggcggc aggcgatgtg
    18181 gtcgggggcc ggggtgaggg cggcgatgcc gtggccgtag ggcaggcgca gggtgcggcg
    18241 gtaggcgccg tcccgccact cctcgacccc gggtacggcg gtcgccgcga ggtggccgaa
    18301 gaggttgtcg gggttgaggg gggcgcggaa ggggaggcgg agggtcagcg cgccgggggt
    18361 cgcgccggcc gctccagccg ctccggtcgc ttcggtcgct ccagccgctt cgttcgctcg
    18421 cgcgggggac cgcttgcggg tgccgacccg ggcgcgcagt tcgctcggtg acagtgcgaa
    18481 gacctcgcgc acggtgtcgt tgaagctgcg gatcgaggcg aaaccggccg cgaaggctat
    18541 gtccgccatc ggcagcgcgg tcgtctcgat cagcagccgc gcggtctggg cgcgctgggc
    18601 gcgggccagg gcgagcggtc cggcgcccag ttcggtgcgg agctcccgtt cgatctggcg
    18661 ggtgctgtag ccgaggagcc gggcgaggcc ggggacgccc tcccggtcca cgacgccgtc
    18721 gccgatgagg cgcatcgcgc gggccacgag gtcggcgcgc cggttccact cgggcgagcc
    18781 cgggctggcg tccgggcggc accgcttgca cgcccggaac ccggcctgct ggcaggaggc
    18841 cgcgctcggg tggaacgtca tgttctccgg cttcggcggc acgaccgggc agctcggccg
    18901 gcagtagatc cgcgtggtcg tgacggccgt gtagaaccag ccgtcgaagc gcgcgtcctt
    18961 cgaccggacg gcgcgtacgc agcgctcgac gtcggtgtgc atcccgtttc gcatggctca
    19021 agcttcgggc agggcggaac gcgtggctgg caggaatccg acatccacct gcgggccgcg
    19081 gggtccggga ccgccgcgcg ttccgcccgc ccgggctccc gcgctagcgc gggagcgaac
    19141 cgggggagga cgccttccgc cacgccgact cccgcagcag ccgcagcccg ttcaggccca
    19201 ccaggaccgt cgagccctcg tgaccggcca cgcccagcgg cagcggcaga tggcccacca
    19261 ggtcccacac caccagtacg gcgatgcagg tgccggcgat gaccaggttc tggacgacca
    19321 ggcgccgggc cgcgcgggac aggcggacga cggcggggat ggccgtcagt tcgtcgcgta
    19381 cgacgacggc gtccgcggtc tccagcgcca ggtcggagcc cgcgcgtccc atcgccacac
    19441 ccgagtgcgc ggaggccagg gcgggcgcgt cgttgacacc gtcgccggcg aagagcacct
    19501 tgcggccggt gccctggagt ccgcgtacgg cgtcgacctt gtcctcgggg aggaggtccg
    19561 cgcggacgtc ggtgatgccg gtgtcggcgg ccacctgtgc cgcggcggac cggttgtcgc
    19621 cggtgagcag gacgggggac gtgccggtga cggcggtgag cgcggagacg gccggagcgg
    19681 cgtcggggcg gaggcggtcg gtgagggtga gggtgccgac gggggtgccg tcgacgcgca
    19741 ccaggaccgt ggtgccgggg acctcgtcgg cgcgaacagc ggccgtgggg tccgggccgg
    19801 caccgtcctc cccggctctc cccaccgtca cgacgcgccc ctccacggtg gcgctgacgc
    19861 cccgtcccgg cctggccgtg aagtcctccg cgggggcgat ccgcagaccg cgggcccggg
    19921 cggcggccac gacggcgcgg gccagcgggt gttcgctcgg gtgctcggcg gccgcggcca
    19981 gggcgagcag ggcgtcctcg ccgagtccgg agcccgggtg cggccgtacg gccgtgacct
    20041 cgggagtgcc ctccgtcagg gtgcccgtct tgtcgagggc ggcggtgtcg atctcgccga
    20101 gccgttccat ggccacggcg gacttgacga gcacaccgtg ccggccggcg ttggcgatgg
    20161 cggagagcag gggcggcatg gtggccagga ccaccgcgca cggcgaggcg acgatcatga
    20221 acgtcatcgc ccggagcagc gcgctcgtga ggtccgcgcc gaaggcgagc gggatcgcga
    20281 agacggcgag cgtggcggcg acgacgccca cggcgtagcg ctgttcgatc ttctcgatga
    20341 acagctgtgt cggcgccttg gtctgcgacg cctcctccac cagggtcacg atgcgggcga
    20401 tcaccgagtc ggccgggtcg cgttcgacgc ggacgcgcag cgcgccggtg ccgttgaggg
    20461 tgccggcgaa gacctcgtcg cccggggcct tcgggacggg caggggttca ccggtgatgg
    20521 tggcctggtc ggcctcgctc tcgccgtcga ggacgcgccc gtcggcgccg atgcgctcgc
    20581 ccgggcggat caggaggacg tcgccgacgg cgagccgatc ggtcgggacc gtctcctcgg
    20641 tctcctcggt gccgtcgccc ttcggcgaga cgcgcgtggc cgtggcgggg gcgagatcga
    20701 gcagaccgcg tacggagtcg gcggtgcggg cggtggccag ggcctccagc gcgccggagg
    20761 tggcgaagat gacgatgagc agcgcgccgt cgaggacctg gccgatcgcg gccgcgccca
    20821 gcgccgcgac gatcatcagc aggtcgacgt ccagggtctt ctcgcgcagt gcacggagcc
    20881 cttcgagggc gggttcccag ccgccggccg cgtaggcgat cgcgtagagc ggcccgtaca
    20941 gccacgccga ggcgccggtc aggtccagcg ggagcgcgag caggaaggcg agggtcgagg
    21001 ccagcgccca gcgggcctcg ggcagggcga ggacacgggt acggcggcgc ggggcgggcg
    21061 tcccgggcgg cctggacgat gccccggacg gggatgcgga ggtggtgaga gtcgcggaca
    21121 cgcggcacac catacaggaa cacatgaaga ctcattcatg ccttcatatg cgatgagtaa
    21181 gatgtgggcc atgggtcatg gagccgccgc acgggaagaa acggcacgcg tacgtctcga
    21241 cgcggccaac gtcgcgaagg tggccaccac cctccaggcc ctctccaccc cgtcccggct
    21301 gctgatcctc gcccggctgc gcgaaggccc gctgcccgcc acggagttgg cggccgaggt
    21361 gggcatggaa cagtcggcgt gctcgcacca gctgcggctg ctgcgcaacc tggggctggt
    21421 cgtgggcgag cggcagggcc gttccgtggt gtacgccctg cacgaccacc atgtcgccga
    21481 gctgctcgac caggccgtct accacgtgga gcacctgcgg ctgggcatca gcgacgcgcc
    21541 cgagggggac ggggactgac cgctgaccgc ccccgtgccc ctcgtggacc ggctgctacg
    21601 ccgtagggcc gacgaccagc aggaccgtgg cggcggccat ggccgtcagg aacagtcccg
    21661 acacggcgca ggcgacgaac acccgtgacg cgcgacgcgg tccgggcact gccggcgccc
    21721 gcgttcccag agccgcccag cgccggctct cctcccgctg ttcgcgtccg cgctggaggc
    21781 gggcgcgcac ccggaccgcc gcggcggcgg ccaggcccgc cgccgccgtc gccgccgtcc
    21841 cggtccacgg catcggcgtg agcagcagca cgccgacggc cgcgagcgtg ccccacgtga
    21901 tcaggcacgc gacggccgcc gaccgctgcg accggggccg gtcggcaccc gcgcggacgt
    21961 ccgccaccgc gggcaggtac cagacgcagc cggaggcgca cagcacggcg gttcccaggg
    22021 ccaggactcc gtcggtcatg gtccgcttct ccttcggttc cgctcctctt cggttccgtc
    22081 cctccctcag ccctgcaccg ctgcgcgctc gtcacgctcg gcacgctcgt cgagcgcggc
    22141 gacctccggg tggtgcaggt cgaacgccgg ggactcggag cggatgcggg gaaggacggt
    22201 gaagttgtgc cgcgggggcg ggcaggaggt ggcccactcc agcgagcggc cgtagcccca
    22261 cgggtcgtcg acgtcgacct tcctgccgta cttgccggtc ctccagacgt tgtagaggaa
    22321 gggcaggatc gacaggccga gcaggaagga cccgatcgag gacagggtgt tcagggcggt
    22381 gaagccgtcg gccgcgaggt agtcggcgta ccggcgcggc atgccctcgg cgccgagcca
    22441 gtgctggacg aggaacgtga ggttgaagcc ggccgtcagc gtccagaagg tgatcttgcc
    22501 gaggcgttcg tcgagcatcc ggccggtcca cttcggccac cagaagtgga agccggcgaa
    22561 catggcgtac acgaccgtgc cgaagagcgt gtagtggaag tgcgcgacga cgaagtacgt
    22621 gtcggagaca tggaagtcga gcggcggcga ggcca
//
