LOCUS       NZ_BMVW01000003        20912 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence03, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000003
VERSION     NZ_BMVW01000003.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 638423)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 292166
            Orig. end                         :: 313078
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20912
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20912
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20912
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10912](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10912)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    940..953
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     misc_feature    complement(1299..1314)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.68"
                     /tool="antismash"
     gene            complement(1311..2402)
                     /locus_tag="IE242_RS11325"
                     /old_locus_tag="GCM10010365_23460"
     CDS             complement(1311..2402)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762967.1"
                     /locus_tag="IE242_RS11325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23460"
                     /product="hydrogenase expression protein HypE"
                     /protein_id="WP_189857993.1"
                     /transl_table=11
                     /translation="MSRPAATAGESPDTDDLVVHLLWINAGLSCDGDSVALTAATQPSI
                     EEIALGALPGLPKVALHWPLLDYECGPDGGADAFIDWFHRAGRGELEPFILVVEGSVPN
                     EAIKREGYWSGFGIDPATGQPITVCEWLDRLAPKATVVLAAGTCAAYGGVHAMAGNPTG
                     AMGVPDYLGWEWRSKADVPIVCVPGCPVQPDNLSETIVHLLYQIAGQAPVIPLDENLRP
                     TWLFDRTVHEGCSLAGYYEQGDFSAAFGQDRCLVKIGCWGPAVKCNVPRRGWINGVGGC
                     PNVGGICIACTMPGFPDRFMPFMDQPSGLHTPATDEGLYGILIRTLRGLTLHDVEKEPE
                     WRRRGHELTTGYEPPWEGRDGHG"
     gene            complement(2399..3073)
                     /locus_tag="IE242_RS11330"
                     /old_locus_tag="GCM10010365_23470"
     CDS             complement(2399..3073)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005476249.1"
                     /locus_tag="IE242_RS11330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23470"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_189857995.1"
                     /sec_met_domain="SIS_2 (E-value: 2.7e-18, bitscore: 61.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDGMRELYPFLYERQADADTVVAEAAGAVRDKAAEITALRREIA
                     RGCAPRIAACAEAMAERLAAGGRLFVFGNGGSSTDAQGLATVFLHPPAGFRVLPALSLT
                     SDAAVVTALSNDVGFEAVFARQLAALGRPGDIAVGLSTSGGSPNVAAALKVAAGRGLLT
                     VGMAGHHGGLLAELDALDHLFVVPSASVHRIQEAQTTVYHTLWELTQLRLRAARPACGD
                     AR"
     gene            complement(3075..3320)
                     /locus_tag="IE242_RS37660"
                     /old_locus_tag="GCM10010365_23480"
     CDS             complement(3075..3320)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS37660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_23480"
                     /product="HypC/HybG/HupF family hydrogenase formation
                     chaperone"
                     /protein_id="WP_229858783.1"
                     /transl_table=11
                     /translation="MLRVVRSLPGDMALAAAEGSAEEPEEISVALVVAPVGTTVLVHAG
                     EAIAAVPDAAPGDTETADTETADTGTGHTRARDTDE"
     gene            complement(3392..3994)
                     /locus_tag="IE242_RS11340"
                     /old_locus_tag="GCM10010365_23490"
     CDS             complement(3392..3994)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024969.5"
                     /locus_tag="IE242_RS11340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23490"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_189857997.1"
                     /sec_met_domain="SIS_2 (E-value: 3.8e-13, bitscore: 44.7,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSPAGEAAVHRAFARREAAVRHLADTAGQVAAVCRDMAARFRC
                     GGKLIVFGNGESAADASHLAVEFMHPVMVGKRALPAVALGNDSATMSGVGAREGFAGVF
                     EHQLRAFADSEDIALGVSPDGRCRNVHRGLAAARQLGLLTVVLSGGLTEEAPAADHLLV
                     VPATDPLVVKEIHMTTYHMLWELVQVFLEQYGPEPVA"
     gene            complement(4033..6243)
                     /locus_tag="IE242_RS11345"
                     /old_locus_tag="GCM10010365_23500"
     CDS             complement(4033..6243)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF018884.5"
                     /locus_tag="IE242_RS11345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23500"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_189857999.1"
                     /transl_table=11
                     /translation="MDRLNRVAELFTECLGCDEEAARTYTRRLLEEPVAPSHPGSSGGG
                     PQPAAAGRPVAQDGAGGGRRTAAGDGPDGRESLAAVSRAPSPVGLARLLHDQVGPHGAS
                     AVLLAAIDRQGELRMSGVAGTSAREADTRSRIPLRCVLPLARTAPEDQLLWIDDDSGDR
                     ILAWVSSRSGPSSPYGGRADGRHGRSPGERLLCVVIVVWPAGPPLEQAVRQRTEELTGS
                     AGRRLCGLADRGLPEENLRAPWLAAVLDVIPIPAALLFPVRDARGRVVAFNIDRCNGHA
                     TDLLGRTPGQITGGRLLEALPGLAHAGIFDAYVKVLETGRPLHRDPFSCEEPFRGVRYP
                     AVLSVRAQRIGGGLLVSWQFHDEQARMAARIDDAERLVDLAWAEWNLITGEITWSRRMY
                     DIFDLDPALGPLSLDRLSQHIGENDLPVLTRAVQTLCEQREPVTFEVRTRHADPPRHVR
                     VTAELVRDSLGNLIAVHGVVQDVSAARRMEAALEASRCEAERHRLRMAEELQLALLPRQ
                     HNTLPGLSMALRYQPAEDSARIGGDWFEATPLPDGRVLIAIGDVSGHGLLAAAGMAQLR
                     HALLGIAHTGADAARILDCLNLVACHSHEETVMATAIVGHFHPHDRTLAWARGGHPPPV
                     LVRAGQARELHNADGISLGATLDPGYRLETVRLQPGDRVILYTDGLVERRDDRRDERSA
                     LLLDAARQGARGGPEEHLQTLLSTLDTNPEDDTCVIVLHVRK"
     gene            complement(7306..8649)
                     /locus_tag="IE242_RS11350"
                     /old_locus_tag="GCM10010365_23510"
     CDS             complement(7306..8649)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE242_RS11350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23510"
                     /product="cytochrome P450"
                     /protein_id="WP_189858001.1"
                     /sec_met_domain="p450 (E-value: 4e-65, bitscore: 215.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPLSQIPEAPGALPLLGHGMMIARRPLAFISSLPAHGDLVRIKL
                     GPRPAYVTTTPELTHRVLVTNARDFERGWLFEKASRFLGSGLGTSSGNAHRRQRRMVQP
                     SFHRDRLPAYSAVMRDQARATALRWRPGQVVDMNHAMDELSMSIATRALFSPALGTHVG
                     DVMRRVLPVLTNGVIRRTSLPDWWAAVPTPGNRRFERAVAELRTAIGTSIAAYRRSGTD
                     HGDLMSMLLASRDDTGAGLTDDEVYDQVVTLISAAVETVGAALAWAFYEIAARPPVQRR
                     LHGELDQVLSGRPPGYDQLPRLVYTRRIVNEALRFSAAWLFMRRSIRQVRLGDVDLPAG
                     TEIIYSPHLLHHDPRWFRDPHRFDPDRWAPDGTALKFPRAFVPYAAGPHQCMGNTFAQL
                     EMVTAVAVICGRWVLRVPPGVRARAVARIDVHPDRAPVIVEHRSTDHP"
     gene            complement(8670..10004)
                     /locus_tag="IE242_RS11355"
                     /old_locus_tag="GCM10010365_23520"
     CDS             complement(8670..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE242_RS11355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23520"
                     /product="cytochrome P450"
                     /protein_id="WP_189858004.1"
                     /sec_met_domain="p450 (E-value: 6.6e-76, bitscore: 250.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGTAIPRLPGGVPGLGHALALRRDPFGLLLRARAWGDVVEIGVG
                     PRPVYVINSPRVIRQILVSDAAHYDKGSLFEKASAVLGNGVVTSSGEFHRQQRRLIHPA
                     FQSTRIPLYAEVMTALAEELSQAWQPGRHLRMDAEMHRLTITTAARTLFSSRLADHAVT
                     EIQHSLPVFLSTITARALSPVPLLEKLPTPGNRRFARARQRMLRAVLSVIDDYRAVGGD
                     QGDLLSMLLAARDADSGRAMPREQVYDEAVTFMVAASESTATALSWAFHYLGNHRAVEE
                     RVRREVRDCLGERAAARHGDLPRLARLRQVLHEVLRLHPLALLPRRALQDVEVDGRHYP
                     RGTQFFISPHALHRDRRHYAAPADFDPDRWAPDRAPHIDPETYLPFGVGRHGCLGESFA
                     WSSMTITLATLLNRFSFTPVPGHRIREVMAGTSRPCHLPMIVHPC"
     gene            complement(10001..10912)
                     /locus_tag="IE242_RS11360"
                     /old_locus_tag="GCM10010365_23530"
     CDS             complement(10001..10912)
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.4"
                     /locus_tag="IE242_RS11360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23530"
                     /product="terpene synthase family protein"
                     /protein_id="WP_189858006.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-43, bitscore: 144.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWDWSRDFLHFGDEKTAERYLDATMEWSEYIAADWDFTTALLAA
                     EWTCTLFLYDDLSRRSTLAQAFVVPAPPGRFVSAEGWLAQAIEDLWKRSAHEASPMAAR
                     RLELALREFFLGCLKELPYRRGVGALRWQGWDTYLCMRRETIGMPVFMALAQVERGMNV
                     TEKAFHATRTAANLVNDHVTLTNDVFSVRKELCSGDCVNGVVAWALHKGTGLQEAVDEA
                     CALIDEKEQQFLAERDRLLSALPELEPYLDRLGHIISGNQHWNYLTPRYHGEGYIWNGL
                     KSGYVELRPDRTVIRSRRTENR"
     misc_feature    complement(10181..10183)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11783..12112)
                     /locus_tag="IE242_RS11365"
                     /old_locus_tag="GCM10010365_23540"
     CDS             complement(11783..12112)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE242_RS11365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010365_23540"
                     /product="hypothetical protein"
                     /protein_id="WP_189858008.1"
                     /transl_table=11
                     /translation="MRTMPPVTLIATLATTEASDARRTLGGSSDAVALHLHHEIAVRRR
                     HETAPVSAGVGLDLGDDTPPAYPTTSTPCCDVGPGQGRSTRGIRWIDSGRPSKRERAAM
                     GGPRE"
     misc_feature    12223..12237
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            12270..13832
                     /locus_tag="IE242_RS11370"
                     /old_locus_tag="GCM10010365_23550"
     CDS             12270..13832
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980130.1"
                     /locus_tag="IE242_RS11370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23550"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_189858010.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.1e-16, bitscore:
                     53.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRDYLIIGAGPAGLQLAASLERDGRDYVVLERGSGPGTFFTRYP
                     RHRQLISINKVNTGYTDPELDLRMDWNSLLSDDPELLFTKYSEEYFPRADDLVRYLADF
                     ADRTGVRVEYGTDVVRVSRENGADGADGVFTVLDAAGRTWRARRLVVATGVSRLNEPPI
                     PGIELAERYDEFDTDPVSFTNQRVLIIGKGNSAFETADALMAKAAVIHVAGPHSLRMAW
                     KTHFVGHLRAVNNNFLDSYQLKSQNAVLDGTVENIERTADGGFRVVFRYARTSERLREL
                     RYDRIILCAGFRFDADVFDGTCRPALVIDDRFPEQTSAYESVNVPGLYFAGTLTQQRDF
                     KKGTNGFIHGFRYGVRALHRILDARYHDAPWPARPLPAAPEAIADAVVARVNRSSGLWQ
                     QFGVLGDVVGVAGDQALYQEEVPLAYATDGGLGPAEHRFVVDLEYGPDHDGVDPFDVTV
                     PRVTENDVEHASDSSYLHPVVRYYRDGVLAGTHHLAENLENEWDVPAVHQQPLAAFVKE
                     CLG"
     gene            13825..15303
                     /locus_tag="IE242_RS11375"
                     /old_locus_tag="GCM10010365_23560"
     CDS             13825..15303
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (25-398). E-value: 4.7e-67.
                     Score: 218.3. Matches aSDomain:
                     nrpspksdomains_IE242_RS11375_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144327.1"
                     /locus_tag="IE242_RS11375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23560"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_189858012.1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-68, bitscore:
                     223.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEAGERGEPGEQFPGLVLELLQAAGGRTVFEHGDRVVSGAQLLG
                     AVRRVTGALREHGVGPGDGVALLLGVSPEAFAAVLAAHVVGARVVGVRPGLTRAQQAHL
                     LADVAFEVTDRSGERSTGRPGTVVLRLDDLLSAADDGIRPRVTARPGDVARLIHTSGST
                     GVPKACAQTYAAMTAGWALRPDAWPPAIRELAARLDRFLVFGTLASQVMMEYGLLALAA
                     GDTLVTADPPDLPGSIVRHRATASVITVARLTKLVAGQRESPVDLGTLRALMVSGSPLR
                     PGRLREAAEVLGPVVFHGYGQTETGMISMATPEDVPGSLGVPPVELAVRDADGRPVLPG
                     TDGELFVRTPGQSTGYWQEPALTAEVFVDGWVRTRDIGRLDGEGRLWLTGRARDVIIVN
                     ANVYYAGPVERLLATHPSVAEAYVVAVPDDSTGEAVHAFVVPAAGRVPSLGELRRLVAA
                     DLGEACAPTRLTLIEEVPLTPAGKPDKRRLAAGA"
     aSDomain        13900..15018
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE242_RS11375_AMP-binding.1"
                     /evalue="4.70E-67"
                     /label="IE242_RS11375_AMP-binding.1"
                     /locus_tag="IE242_RS11375"
                     /protein_end="398"
                     /protein_start="25"
                     /score="218.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="GGRTVFEHGDRVVSGAQLLGAVRRVTGALREHGVGPGDGVALLLG
                     VSPEAFAAVLAAHVVGARVVGVRPGLTRAQQAHLLADVAFEVTDRSGERSTGRPGTVVL
                     RLDDLLSAADDGIRPRVTARPGDVARLIHTSGSTGVPKACAQTYAAMTAGWALRPDAWP
                     PAIRELAARLDRFLVFGTLASQVMMEYGLLALAAGDTLVTADPPDLPGSIVRHRATASV
                     ITVARLTKLVAGQRESPVDLGTLRALMVSGSPLRPGRLREAAEVLGPVVFHGYGQTETG
                     MISMATPEDVPGSLGVPPVELAVRDADGRPVLPGTDGELFVRTPGQSTGYWQEPALTAE
                     VFVDGWVRTRDIGRLDGEGRLWLTGRARDVIIV"
     CDS_motif       14290..14334
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE242_RS11375_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="IE242_RS11375"
                     /protein_end="170"
                     /protein_start="155"
                     /score="15.2"
                     /tool="antismash"
                     /translation="LIHTSGSTGVPKACA"
     CDS_motif       14839..14925
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE242_RS11375_0002"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="IE242_RS11375"
                     /protein_end="367"
                     /protein_start="338"
                     /score="24.7"
                     /tool="antismash"
                     /translation="PGTDGELFVRTPGQSTGYWQEPALTAEVF"
     gene            complement(15432..16712)
                     /locus_tag="IE242_RS11380"
                     /old_locus_tag="GCM10010365_23570"
     CDS             complement(15432..16712)
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058293.1"
                     /locus_tag="IE242_RS11380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23570"
                     /product="cation:proton antiporter"
                     /protein_id="WP_189858014.1"
                     /transl_table=11
                     /translation="MTPAELAPKFFLAVVVILVVCRAVSRLLQTVGQPPVVGEMIAGVV
                     LGPSVLGALLPGVESGLFPQELRPVLYVVGQIGLVAFMFRVGWDFRVDRLRGVARPAGL
                     VSAAGVVVPVLLGVLLIYAVGERTGALAEDVPLLVSALFVGVALAVTAFPMLARIIAER
                     GLTGTRYGSLALGAGSVDDAVAWILLAGVFSIAGGSAGLVSLAVAGGFGLVLVMVGVVR
                     LHGRTTLLADRVTPDSLLLTLVGALFLVAWYTDETGLYAVFGAFCLGLVFPRSQQLDRT
                     VETLKPVGTVFLPLFFTYSGLNTDFTLLGSGPVLLFTAGCVLFAVAGKFGACWLAARAA
                     GEPNQVALRVGALMNARGLMQLIALNLGLAAGIVTQAMFSALVVVAVVTTVMATPLLSW
                     IDRRERTRTGTRGDGARPAPAVAVESH"
     gene            complement(16709..18085)
                     /locus_tag="IE242_RS11385"
                     /old_locus_tag="GCM10010365_23580"
     CDS             complement(16709..18085)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144329.1"
                     /locus_tag="IE242_RS11385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23580"
                     /product="cytochrome P450"
                     /protein_id="WP_229858791.1"
                     /sec_met_domain="p450 (E-value: 6.8e-18, bitscore: 59.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSGTKPATADTWWLPRGVVALRGRIFEKVNGDRTVTLPDAAHGP
                     DVFERVYAHPAANGRSAGAGLSDLFWYWLSPGPEVHQEHLEPGERYEDVAAATRRMLAG
                     SSAELAAAAGRAVARVLDTVPDTRISLVRLRDLVMPAWAEFCYEMVFREPCPPRARELI
                     TAHADDVINALKCTGLRHPGRRARLTAYLRERVAAGDVPHELPASLSPQEQVHYLQGTM
                     FNTAVVQLSEATAHVLLALARHPEVQQRVWAHPDDDRYLTHVLDETMRLYPLFGIAHRI
                     TTDAIPLDEHTTLPAGSVVCFSYPGYHATGYDRPDAFDPDRWDTLSAKDAHFIPFGVAA
                     NRPCPAWRLSPLVLRAAVREVLRRFRLDSTASHTRSNPHRAPCLLIPRGLSPQPRRTEA
                     LRRFVRVRDGVEDVTRSVRQLVLGTVMVLHARRQRLAERYFEESPAGRCPVAHQGGNRG
                     "
     gene            complement(18099..19169)
                     /locus_tag="IE242_RS11390"
                     /old_locus_tag="GCM10010365_23590"
     CDS             complement(18099..19169)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522351.1"
                     /locus_tag="IE242_RS11390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23590"
                     /product="alpha-hydroxy acid oxidase"
                     /protein_id="WP_189858018.1"
                     /transl_table=11
                     /translation="MMLRALYDAARKTLDPVHYDYVAGGAGEERVVAGNEGAFDRYALL
                     PRVLCGSEVRDTAVDLPGARRAAPVVVAPTAFHRLLHPGGERATARAAAAEGAVLVTGT
                     AATTAVADVVAAAREAAADPAVWFQLYLHPRREVTEALVRRAERAGCTALVVTVDSPVF
                     GRHTRDLRNGFTDLPPGYAAENMRGLPGAPPDGLTDIPMSPSLSWRDLGELLHMTSLPV
                     LVKGVLHPADATVAVEHGAAGVIVSNHGGRQSDAVPAAVDCLPAVARAVAGRVPVLLDG
                     GIRRGSDVAVALALGAAAVGVGRPAVWGLAAEGEAGVRAVLRTLCDEYDHTLALCGGRR
                     NTDLARDMVVRKGETW"
     gene            complement(19166..20782)
                     /locus_tag="IE242_RS11395"
                     /old_locus_tag="GCM10010365_23600"
     CDS             complement(19166..20782)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522352.1"
                     /locus_tag="IE242_RS11395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_23600"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_189858020.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2e-18, bitscore:
                     61.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHDYLIIGAGPAGLQLAAFLERDGADYVVLERGSGPGTFFTRFP
                     RHRTLISINKVHTGYDDPELRLRMDWNSLLSDDPELLFTRYSPRYFPPADDMVRYLSDF
                     ATRTGARVEYDTAVEKVSRDGDGDGDGFTVTDHTGKTWRARRLVIATGVSLPNLPSVPG
                     IELAERYDTFDPDPESFTGQRVLIIGRGNSAFETADSLMETASVIHVVGSGSLRLAWQS
                     HYVGHLRAVNNNFLDSYQLKSQNALLDGRVLEIRRDADGGFSVPVAFERVDEVVKDIRY
                     DRVIVATGFRFDTSVFDDSCVPDLIVDGRFPALTPVGESVNVPGLYFAGTITQGPDFKK
                     STTGFIHGFRYMVRALHRALRKRHHGEDWPAAELGDAVERAVDAVVTRVNRSSALWQQF
                     AVLGDVLLVAPDGTMRYAEEVPVRHVPDAVRAGDFGEVAAHAVITLEYGADHDRVDPFD
                     VTAGRKSQQDVQGLDGRYLHPVVRWYRGGEFVSEHHLTENLENEWDSEEVHRAPLRAFL
                     TDHLNPAAPAAPVAPVAPVAP"
     misc_feature    20837..20857
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 gggcgcggtt gcgctcgatg gtgttgctca gcggctgtcc gttgtgctcc gggatcttcc
       61 actcgaaggt gacctcgggc ttggtggcgg tgcgtggcag gtggatgagg acgctgtgtc
      121 ccgtggcctt gagatggccg gtgtcgacca gaccggacag tgccgtcgac cacagccggg
      181 ccagcgggcc gccgccggtg tccagcgcca ggtgctcggt cccgtcgaac caccgggggg
      241 acatcaccca gctgtacttg tccgcgaagt cgcgcttctg cggccgcggg accgtgcgct
      301 ggttccacgg gtgccgctgg tcgaccgggt tgcccagcgg gtcctcggtg acgaacggct
      361 ccccgtcgtc ccagtcctgg tagaaggagc tgccgagcag gatgcggatg ccgaggttga
      421 tgtccaccag gttgctggtc accaggcggc cgtcgaccac cacgcccggg gtcacgaaca
      481 tcctgcgccc ccagtccgcc atggtggggt agcggaagtc gcagtgcgcg gggtcgttga
      541 gggcgcccca gcagccgagc agcaccctgc gccggccgac ctcctcgtac ccgggcatgg
      601 cctggtagat gaagtcgaac aggtcgtcgt gcaggggcac gaccttcttc atgaactcga
      661 cgtagcgcat caggcgggtg aggtagtcgg tgaacagctg caccgtggcg acggtgctga
      721 caccgcccgg atacacggtc gacgggtgca catgccgccc ctccatcagg cagaacatct
      781 ccctcgtgga gcggctgacc tggagcgcct cccggtagaa ctcgccctgg agcggattga
      841 gcgagcgcat gatggacgcg atggtccggt ggccgtgctc ggccgcgtgg ggggcctcgg
      901 tgcgttcggc gagttcgtac acacccgggt tcgtctcgcg gaccatgcgt tcgcagtagt
      961 ccacgccgac caggttctcc tggaagaggt tgtggtcgaa catgtactcg gcggcctcgc
     1021 cgaggttgag gatccactcc cccagggccg gcggccggac accgtaggcc atgttctgcg
     1081 cgtacaccga gcacgtggag tggttgtccc cgcagatgcc gcagatgcgg ctggtgatga
     1141 agtgcgcgtc ccgggggtcc ttcccctgca tgaagacgct gtagccgcgg aagaccgacg
     1201 aggtgctgta gcactcggcc acccggccgc gcccgaagtc gatcttcgta tggatgccca
     1261 ggctccccac gatgcgggtg atggggtccc acgccatctc gaccagaccg tcacccatgt
     1321 ccgtcccttc cttcccaggg gggctcgtag cccgtggtca gctcgtggcc cctgcggcgc
     1381 cactccggtt ccttctcgac gtcgtgcagg gtcaggccgc ggagggtgcg gatgaggatc
     1441 ccgtacagcc cctcgtccgt tgccggggtg tgcaggccgg acggctggtc catgaagggc
     1501 atgaaccggt cggggaagcc gggcatggtg cacgcgatgc agatgccccc gacattgggg
     1561 cagccgccga ctccgttgat ccagccgcgt ctgggcacgt tgcacttcac cgcggggccc
     1621 cagcagccga tcttgaccag gcatctgtcc tgaccgaacg cggcactgaa gtcaccctgc
     1681 tcgtagtagc cggccagact gcagccctcg tgcacggtcc ggtcgaacag ccaggtggga
     1741 cggaggttct cgtccagcgg gatcacgggg gcctggccgg cgatctggta gagcagatgg
     1801 acgatggtct cggagaggtt gtcgggctgg accgggcagc ccggcacgca cacgatcggg
     1861 acgtccgcct tcgaccgcca ctcccagccc agatagtcgg gcacccccat ggcgccggtc
     1921 ggattgccgg ccatcgcgtg gacgccgccg tacgcggcgc aggtacccgc cgcgagcacc
     1981 acggtggcct tgggcgccag ccggtccagc cactcgcaca cggtgatggg ctggcctgtc
     2041 gccgggtcga tgccgaaccc gctccagtac ccctcccgct tgatcgcctc gttcggtacg
     2101 gagccctcga cgaccaggat gaacggctcc agctcgccgc ggccggcccg gtggaaccag
     2161 tcgatgaagg cgtcggcacc gccgtccggt ccgcactcgt agtccagcag cggccagtgc
     2221 agggcgacct tcggcagtcc cggcagggca cccagcgcga tctcctcgat gctcggctgg
     2281 gtggccgccg tgagcgcgac cgagtcgccg tcgcagctga gcccggcgtt gatccacagc
     2341 aggtggacca cgaggtcgtc ggtgtccggg gattccccgg cggtcgcggc aggacggctc
     2401 atcgtgcgtc accgcacgcc ggccgtgccg cgcgcagcct cagctgagtc agctcccaca
     2461 gggtgtggta cacggtcgtc tgcgcctcct ggatgcggtg gaccgaagcg gacgggacga
     2521 cgaagagatg gtcgagggcg tcgagttcgg ccagcagtcc gccgtggtgg cccgccatgc
     2581 cgacggtgag caggccgcgc ccggccgcca ccttcagggc cgccgccacg ttcggggaac
     2641 ccccgctggt cgacagcccc acggcgatgt ctcccggccg tcccagggcc gccagctggc
     2701 gcgcgaagac ggcctcgaaa ccgacgtcgt tggacagcgc ggtcacgacg gccgcgtcgc
     2761 tggtcagtga cagcgcgggc aggacccgga agccggccgg cggatgcagg aacacggtgg
     2821 cgaggccctg ggcgtcggta ctgcttccgc cgttgccgaa gacgaacaga cgtcccccgg
     2881 ccgcgagccg ctccgccatg gcttcggcgc acgcggcgat ccgcggcgca cagccgcgcg
     2941 cgatctcccg ccggagtgcg gtgatctcgg cggccttgtc ccggacggca ccggccgcct
     3001 cggcgaccac ggtgtcggca tcggcctgcc gctcgtagag gaacggatac aactcccgca
     3061 ttccgtcgtg catgtcactc atccgtgtct cgcgcccttg tgtgccccgt ccccgtgtct
     3121 gccgtctccg tgtctgccgt ctccgtgtct cccggcgcgg catccggcac ggccgcgatg
     3181 gcctctccgg cgtggacgag aacggtcgtc ccgaccggcg ccacgacaag cgccacgctg
     3241 atctcctccg gttcctcggc cgacccctcg gcggcggcca acgccatgtc gccgggcaac
     3301 gacctcacga cccgcagcaa gcgcgcttcg tccgagcagg tgacgcagac gtcctcgggg
     3361 cattccggtc ggtcccggcc gtcccatgac ctcatgcgac cggctccggc ccgtactgtt
     3421 cgaggaaaac ctgtaccagt tcccacagca tgtggtaggt ggtcatgtgt atctccttga
     3481 ccaccagggg atcggtggcc ggcaccacca gcagatggtc ggctgcggga gcctcctccg
     3541 tcaggccacc gctgaggacg acggtgagca ggccgagttg ccgggccgcc gccaggccgc
     3601 ggtgtacgtt ccggcagcgg ccgtccggcg agaccccgag cgcgatgtcc tcgctgtcgg
     3661 cgaacgcccg cagctggtgc tcgaagaccc cggcgaaccc ctcccgcgcg ccgactccgc
     3721 tcatggtcgc cgagtcattg ccgagcgcca cggccggcag ggcccgtttc cccaccatga
     3781 cggggtgcat gaactcgacc gccaggtggc tcgcgtcggc cgccgactcg ccgttgccga
     3841 acacgatcag cttgccgccg caccggaatc gggcggccat gtcgcggcag acggcggcca
     3901 cctgcccggc ggtgtccgcc aggtgccgca cggccgcctc gcggcgggcg aaggcgcggt
     3961 gcacggccgc ctcgccggcc ggggaggaac tcatgggcgt gctcccttgc acggggtccc
     4021 gggcgtcatc gctcacttcc tcacatggag gacgatgacg cacgtgtcgt cctccggatt
     4081 ggtgtccagc gtggacagca gggtctggag atgctcctcg ggtccgccgc gggcgccttg
     4141 ccgggcggcg tccaggagca gggccgagcg ctcgtcgcgc cggtcgtcgc ggcgttcgac
     4201 caggccgtcg gtgtagagga tgacccggtc gccgggctga agccggacgg tctcgagacg
     4261 gtatccggga tccaaggtgg cacccagtga gatcccgtcg gcgttgtgca gctcacgagc
     4321 ctgtcccgcc cggacaagga cgggaggggg gtggcctccc cgggcccagg ccagggtgcg
     4381 gtcgtgcggg tggaagtgcc cgacgatcgc ggtggccatc acggtctcct cgtggctgtg
     4441 acaggcgacg agattgaggc agtcgaggat gcgggccgcg tcggcgcccg tatgcgcgat
     4501 gcccagcagg gcatggcgca gctgcgccat gcccgccgcc gcgagcaggc cgtgcccgct
     4561 gacgtccccg atggcgatca gtacccggcc gtcgggaagc ggagtcgctt cgaaccagtc
     4621 gccgccgatg cgcgcactgt cctccgccgg ctggtagcgc agcgccatcg acaggccggg
     4681 gagcgtgttg tgctgccgtg gcagcagcgc cagttgcagc tcctcggcca tgcgcagccg
     4741 gtgacgttcc gcctcgcacc gcgaggcttc gagcgccgcc tccatccgtc gggcggcgga
     4801 gacgtcctgg acgactccgt gcaccgcgat caggtttccg agactgtccc ggaccagttc
     4861 ggcggtgacg cgcacatggc gtggggggtc ggcatggcgc gtgcggacct cgaacgtcac
     4921 cggttcacgc tgttcgcaga gtgtctgtac ggcccgggtg aggaccggga ggtcgttctc
     4981 cccaatgtgc tgggagagcc ggtccaggga gagcgggccc agcgccggat ccaggtcgaa
     5041 gatgtcgtac atgcgccgtg accacgtgat ctcgccggtg atcaggttcc actcggccca
     5101 cgcgaggtcc accagccgct cggcgtcgtc gatccgggcc gccatccgtg cctgttcgtc
     5161 gtggaactgc cagctgacca gcagcccgcc gccgatccgt tgagcccgca cgctcagcac
     5221 ggcggggtat cgcactccgc ggaacggctc ctcgcaggag aaggggtcgc ggtgcagggg
     5281 cctgccggtc tccagcacct tcacgtaggc gtcgaagatt ccggcgtggg ccaggccggg
     5341 aagtgcctcc aggagccggc cgccggtgat ctggccgggc gttcgcccca ggaggtccgt
     5401 ggcgtgcccg ttgcagcggt cgatgttgaa tgcgacgacc cggccacggg cgtcccggac
     5461 cgggaagagc agtgcggcgg ggatggggat gacatcgagg accgcggcga gccacggcgc
     5521 acgcaggttc tcctcgggca gcccccggtc ggccaggccg cacagcctcc gtccggcgga
     5581 gcccgtcagt tcctccgtgc gttgccggac cgcctgttcc agcggcgggc cggccggcca
     5641 gacaacgatc accacacaca ggagacgctc ccccggagag cgaccgtgcc ggccgtcggc
     5701 ccggccaccg tacgggctcg acgggccgct cctggacgag acccacgcca ggatccggtc
     5761 gccactgtcg tcgtcgatcc acagcagctg gtcctccggg gccgtccggg cgagggggag
     5821 cacacaccgc agggggatcc gcgaccgggt gtcggcctcc cgtgccgatg tgccggcgac
     5881 accgctcatg cgcagttccc cctgccggtc gatggccgcc agcagcaccg ccgaggcgcc
     5941 gtgcggcccg acctgatcgt gcagcagtcg cgccagtccg acgggactcg gcgcacggct
     6001 caccgccgcg aggctctcgc ggccgtccgg gccgtcgccc gcggccgtcc gccggcctcc
     6061 gccggcaccg tcctgcgcca ccgggcggcc cgcggccgcc ggctgcgggc cgccgccgga
     6121 ggaacccggg tgcgacggtg cgacgggctc ttcgagcagt cgccgcgtgt acgtgcgcgc
     6181 cgcctcctca tcacacccga ggcattccgt gaacagctcc gcgacccggt tcagacggtc
     6241 catgcgtgac gacgcggtcc atggctgtgg accgactgcc tcccgcggtg ccgaaccatg
     6301 ccgcttcccc atttcgctca caggttccat cgcccgggtc tagggtgtgc cttccacgct
     6361 cacggagatc gcgtgccatc ggtgttaccg ggagcgctca acctgtgttg tctactggca
     6421 tcggcgcggc cacggcctgt gatgacggct attgtccgga gcagcctgga gagtggcgtc
     6481 acagggacat ccgttacgcc atttatggcg gttcctgatc ggccctggaa acagtggtta
     6541 cgtccggcag aacgggccgg ggcgatgagc ccgggtactg cacgtctgcg agctgagggg
     6601 gcgggctgtc cacgacgacc gcggtcctgg ccccggtcgg ggtgcagcgg ggcttgacct
     6661 cggcgtcgtc ggctcacttg cccgagcccg gacctctgtc ccccgcgtgg ggcgtcaccc
     6721 ggcggaacct cggcgaggcc taccgcgcgc acccgggggg acggcgcgac aacctcgaac
     6781 gtgccgtcgc cgcctacgtt ggccgcccag cccggactgt gggccatgac ccagtacagc
     6841 ctcgcagcgg cctgtcccgc ccgcccggaa ggtggtcggc gaccggatcg ggcgaggcca
     6901 gggcggcccg agcgggcttg atgcggacgc ccacctccgc aggcaggccg gaccccggcg
     6961 gccaacgcgg cccgcgccgc gaccgcctac cagcgctgcc tggcggccct ggacgcgacg
     7021 gatcccccgg cgacgcgggc ggagctgctc cgtggcctcg gcgacgccca ccgcatggcc
     7081 ggtgcggact gcgcccccgc gccgtcgagg cgtaccgcgc cgccgtggaa gcccgccctg
     7141 agggctcccg gtccccggca ggcactcggc atcaccgaga cgctgactgt gttccatgcg
     7201 ctgcacggct cgccgagcag gccgctcggt gcgctcgacg gctcaggctg ggccgtccca
     7261 ccccgtccaa cgcaccggaa cagccgcccc cgggctcccg tggtgtcatg gatgatccgt
     7321 gctccggtgc tcgacgatca ccggtgcccg atctggatgg acgtcgatgc gggccacggc
     7381 tcgcgcccgg acgcccgggg ggacgcgcag gacccaacgc ccgcagatca cggcgacagc
     7441 tgtgaccatt tcgagttggg cgaaggtgtt ccccatgcac tgatgggggc cggcggcgta
     7501 ggggacgaag gccctgggga acttcagcgc ggtgccgtcg ggggcccaac ggtcgggatc
     7561 gaagcgatgc gggtcacgga accagcgggg atcgtggtgc aggagatggg gactgtagat
     7621 gatctccgtc cccgccggca ggtcgacgtc ccccaaccgg acctgccgga tgcttctgcg
     7681 catgaacagc caggccgcgg agaaccgcag cgcctcgttc acgatgcgcc gggtgtagac
     7741 gagccggggc agctgatcgt agccgggcgg tcggccggac aggacctgat cgagctcgcc
     7801 gtggaggcgt cgctgtacgg gcggacgggc ggcgatctcg tagaacgccc aggcaagggc
     7861 ggctcccacc gtctccaccg cggcggagat gagggtgacc acctggtcgt acacctcgtc
     7921 gtcggtcaac cccgcgccgg tgtcgtcccg gctcgccagc agcatcgaca tgaggtcgcc
     7981 gtgatccgtg ccgctgcgcc ggtaggcggc gatggacgtc ccgatcgccg tacgcagctc
     8041 cgccaccgcc cgctcgaagc ggcggttgcc gggcgtgggc acggctgccc accagtcggg
     8101 gagcgaagtg cgccggatca cgccgttggt caggacggga agcacacggc gcatcacgtc
     8161 gccgacgtgg gtgcccagcg cgggggagaa cagtgcccgg gtcgcgatgg acatggacag
     8221 ttcgtccatc gcgtggttca tgtccacgac ctggcccggc cgccaacgca gtgcggtggc
     8281 ccgcgcctgg tccctcatca ccgcggagta ggccggcagc cggtcgcggt ggaaggacgg
     8341 ctgcaccatg cggcgctgac gccggtgcgc gttccccgag gacgtgccca ggcccgatcc
     8401 caggaagcgg gacgccttct cgaagagcca accgcgttcg aagtcacgcg cgttcgtgac
     8461 cagcacccgg tgggtgagtt cgggagtggt ggtgacgtac gcgggccgtg gcccgagttt
     8521 gatgcggacg aggtcgccgt gggcggggag cgaggagatg aaggcgagcg ggcggcgagc
     8581 gatcatcatc ccgtgaccga ggagcggaag agcgccggga gcttcgggga tctgtgagag
     8641 cggcgtcatg cgtgcctcca acggagcggt cagcagggat ggacgatcat cggtaggtgg
     8701 cacggcctgc tcgtgccggc catgacctcc cggatccgat ggcccggcac cggggtgaag
     8761 ctgaatcggt tgaggagcgt ggccaaggtg atggtcatgc tggaccaggc gaaactctcg
     8821 ccgagacagc cgtgccggcc cacgccgaac ggaaggtagg tctccgggtc gatgtgcggg
     8881 gcccggtcgg gagcccagcg gtcggggtcg aagtcggccg gagcggcgta gtgacgccgg
     8941 tcgcggtgca gggcgtgagg gctgatgaag aactgcgtgc cacgcggata gtgccggccg
     9001 tccacttcca cgtcctggag cgccctgcga ggcagcagtg ccaggggatg cagccgcagt
     9061 acttcgtgca ggacctggcg aaggcgggcg agccggggca ggtccccatg gcgagcagca
     9121 gcccgctcac cgaggcagtc ccgcacctcg cggcgtaccc gctcttcgac ggcccggtgg
     9181 ttccccagat agtggaaggc ccacgacagt gcggtggccg tgctctcgga cgcggcgacc
     9241 atgaaggtga ccgcctcgtc gtagacctgc tcacgtggca tggcccgtcc gctgtccgcg
     9301 tcgcgtgcgg cgagcagcat ggacagcaga tccccctggt cgccgcctac ggcgcggtag
     9361 tcgtcgatga cgctcaggac tgccctgagc atccgctgcc gcgcccgggc gaaacggcgg
     9421 ttccccggcg tggggagctt ctcgagaagg ggcaccggag acagtgcccg ggcggtgatg
     9481 gtcgacagga agacggggag cgagtgctgg atctccgtga ccgcgtgatc cgctaggcgc
     9541 gaggagaaca gtgtccgggc cgcggtggtg atggtcagac ggtgcatctc cgcgtccatc
     9601 cgcaggtgcc ggcccggctg ccatgcctgg gagagttctt cggccagagc cgtcatcacc
     9661 tcggcgtaca aggggatgcg ggtgctctgg aacgccgggt ggatcaggcg ccgctgctgt
     9721 cgatggaact ccccgctgga ggtgacgaca ccattgccca gcactgcgga agccttctcg
     9781 aagagcgagc ccttgtcgta gtgcgcggcg tcggacacca ggatctgccg gatgacgcgt
     9841 ggggagttga tcacatagac ggggcgtggg ccgacgccga tctccaccac gtcaccccag
     9901 gcgcgtgccc gcagcaggag gccgaaggga tcacgccgca gggccagtgc gtgccccagc
     9961 ccgggtactc cccctggcag ccggggaatc gcggtgccgc tcatcggttc tccgtccgcc
    10021 gagaacggat gaccgtgcgg tccggccgta gttccacgta tccggatttg aggccgttcc
    10081 agatgtagcc ctcaccgtgg tagcgcgggg tgaggtagtt ccagtgctgg tttccgctga
    10141 tgatgtggcc gagcctgtcc aagtaaggtt ccagttccgg taatgcggag aggagacggt
    10201 cacgctcggc caggaactgc tgttccttct cgtcgatcag ggcgcatgcc tcgtccacgg
    10261 cttcctggag cccggtcccc ttgtgcaggg cccaggccac gaccccgttg acgcagtcac
    10321 cgctgcacag ttccttgcgg acggagaaga cgtcattggt cagagtgacg tggtcattga
    10381 ccaggttggc ggccgtccgt gtggcgtgga acgccttctc cgtgacgttc atgccacgct
    10441 ccacctgggc cagcgccatg aagacgggca tgccgatggt ctccctgcgc atgcacaggt
    10501 aggtgtccca gccctgccag cgcagcgctc ccactcccct gcggtacggg agttccttga
    10561 ggcagccgag gaagaactcc ctcagcgcca gctccaggcg ccgcgccgcc atgggcgagg
    10621 cctcatgcgc cgagcgcttc cacaggtcct ctatcgcctg ggcgagccat ccctccgcgg
    10681 agacgaaccg ccccggcgga gcgggcacca cgaaggcctg cgccagagtc gatcggcggg
    10741 acaggtcgtc gtacaggaac agagtgcacg tccactccgc ggcaagcagc gcggttgtga
    10801 aatcccagtc cgccgctatg tactcgctcc actccatcgt ggcatcgagg taacgctctg
    10861 ccgtcttctc gtcaccgaag tgcaggaaat cacgcgacca atcccatgtc atggcttcga
    10921 gtcgcggttt gtcctggtga atacggacag gaatgcgcat ggggagcggc ggcaggtaga
    10981 acgaccccat cctctgcagg agtcgtgaca catcacacgc tgccgacttc acttcgtcag
    11041 gcacctcaca ccacctttct cgttctttgg tcgggttgcg gccgcggagc ggcatacctt
    11101 cccgggccct ggccgcactg accgcgccgc ggccgacgcc cacgccttcc tgctgaacgg
    11161 gaacctccct tcgcggctac ggctgcatcg gggatgaggc cgagagtttc gtcgagcaga
    11221 ggacacaccg gattccgtga cgatctcgat cacttgcctc gcgtgcggaa acatccggcc
    11281 cattccgttg ccacacggca caccgaggtc ggcttcgcgg cattcggcgg gtccgtcgac
    11341 cacgcggctc acgcccacga tccggaggga gtgagggaag ctgccgaagg cctacgggag
    11401 accgcaccag cacggcgaga cccgcatcgc ctgggccacc accgccctga tgctccggca
    11461 gctgaccgga ccggtcggac gacggcccgt gcgaccgcga caggcggcgg ccccggcaac
    11521 caggacggtg cggatccgga ccggcctacg gaatgtcctc atgacgcctc ccatgtcccc
    11581 gggacccaga cggcggtcga tgagtcgcgc tccgcccagg gcgataacag ggtgatgcga
    11641 acgcggcatg ccgggaaggg agcgagcctg tgccggtaca gggcgctcga caacacccga
    11701 acaggaacac acgcttccat gtgataggga cgtgtcccat gggtttgatg tgtcgagtgg
    11761 cagcctcctc cttgggcttg gctcactccc gcggaccacc catcgcggcc cgctctcgct
    11821 tcgacggtcg gccgctgtcg atccagcgga tgccccgcgt tgaacgtccc tgtccggggc
    11881 cgacatcaca gcagggcgtg gacgtggtcg ggtaggcggg cggggtgtcg tcgccgaggt
    11941 cgagtccgac accggccgac accggggcgg tctcatgcct tctgcgtacg gcgatctcgt
    12001 ggtgtaggtg cagggcgacg gcgtcactcg agccgcccag cgtccggcgg gcgtcgctgg
    12061 cctccgtcgt ggcgagcgtc gcgatcagcg tcaccggcgg catcgtccgc atcaccggct
    12121 ccggacaacg ctgacacgcc cgtcgccccg agcggtgacg aaggagcttc atgccgtggg
    12181 aaggcggcgt gccggacgga gccggacaga gccgaaccga gcttcccaat ctcagagccc
    12241 tctgatgtca cgccgctaac gtccagtcca tggtgcgcga ctacctgatc atcggggccg
    12301 gaccggccgg acttcagctc gccgcttcgc tggaacgtga cggacgggac tacgtcgtcc
    12361 tggagcgggg aagcggaccc ggcacgttct tcaccaggta ccccagacat cggcagctca
    12421 tctcgatcaa caaggtgaac accgggtaca ccgacccgga actcgacctc cggatggact
    12481 ggaactcgct gctcagcgac gacccggaac tgctgttcac caagtacagc gaggagtact
    12541 tcccccgcgc cgacgacctc gtgcgctatc tggccgactt cgcggaccgc accggcgtcc
    12601 gcgtcgagta cggcaccgat gtcgtgcggg tctcccgtga gaacggcgcg gacggcgcgg
    12661 acggcgtctt caccgtcctc gacgccgccg gacggacgtg gcgggcgcgg cggctcgtcg
    12721 tggcgaccgg cgtctcccgg ctcaacgagc cgcccatccc cggcatcgaa ctcgccgagc
    12781 gctacgacga gttcgacacc gacccggtgt ccttcaccaa ccagcgggtg ctgatcatcg
    12841 gcaagggcaa ctccgcgttc gagacggccg acgccctcat ggcgaaggcc gcggtcatcc
    12901 acgtcgccgg cccgcactcg ctcaggatgg cctggaagac ccacttcgtg ggccacctgc
    12961 gcgcggtgaa caacaacttc ctggacagct accagctcaa gtcccagaac gccgtcctgg
    13021 acggcaccgt ggagaacatc gagaggaccg ccgacggcgg gttccgggtg gtcttccgct
    13081 acgcccggac ctcggaacgc ctccgcgagc tgcgctacga ccggatcatc ctgtgcgccg
    13141 gcttccgctt cgacgcggac gtcttcgacg ggacctgccg ccccgcactc gtcatcgacg
    13201 accgcttccc cgagcagact tccgcctacg agtcggtgaa cgtgccgggc ctgtacttcg
    13261 ccggcacgct gacccagcag cgcgacttca agaagggcac caacggcttc atccacggct
    13321 tccgttacgg ggtgcgcgcc ctgcaccgca tcctggacgc ccgctaccac gacgcgccct
    13381 ggcccgcccg gccactgccc gcggcgcccg aggcgatcgc cgacgccgtc gtcgcccgcg
    13441 tcaaccgctc gtccgggctc tggcagcagt tcggggtcct cggtgacgtg gtcggggtgg
    13501 cgggcgacca ggccctgtac caggaggagg tgccgctcgc gtacgccacc gacggtggtc
    13561 tcggtcccgc cgagcaccgg ttcgtcgtcg acctggagta cgggcccgac cacgacggcg
    13621 tcgacccgtt cgacgtcacc gtcccgcgcg tgaccgagaa cgacgtggag cacgcgagcg
    13681 actccagcta cctccacccc gtcgtccggt actaccgcga cggcgtcctc gccggcaccc
    13741 accatctggc ggagaacctg gagaacgagt gggacgtccc ggcggtccac cagcagccgc
    13801 tcgccgcgtt cgtgaaggag tgccttggct gaggcaggtg agcggggtga gccgggtgag
    13861 cagttcccgg gcctggtact cgagctcctc caagcggcgg gcggccggac ggtgttcgag
    13921 cacggcgacc gggtggtgtc cggagcccag ctgctcgggg cggtacggcg ggtgaccggc
    13981 gcgctgcggg agcacggtgt cgggcccggc gacggggtcg ccctgctgct gggcgtcagc
    14041 cccgaggcgt tcgccgccgt cctcgcggcc catgtcgtgg gcgcccgtgt cgtcggcgta
    14101 cggccgggcc tgacccgggc ccagcaggcg catctcctcg cggacgtcgc cttcgaggtc
    14161 accgaccgga gcggcgagcg gagcaccggg cggccgggga ccgtcgtcct ccggctcgac
    14221 gacctgctgt cggcggcgga cgacggaata cggccgcggg tcacggcacg gccgggggac
    14281 gtcgcccggc tcatccacac cagcggcagc accggcgttc ccaaggcgtg tgcccagacg
    14341 tacgcggcga tgaccgcggg ctgggcgctc cggccggatg cctggccgcc cgccatccgt
    14401 gaactcgccg cgcgcctgga ccggttcctg gtgttcggca ccctggcgag tcaggtgatg
    14461 atggagtacg ggctgctcgc gctcgcggcg ggcgacaccc tggtcaccgc cgacccgccg
    14521 gacctccccg gcagcatcgt gcggcaccgg gcgacggcgt ccgtcatcac cgtggcccgg
    14581 ctgacgaaac tcgtggcggg ccaacgggag tcacccgtgg acctcggcac gctgcgcgcg
    14641 ctgatggtgt ccgggtcccc gctgcggccg gggcggctgc gcgaggccgc cgaggtgctc
    14701 ggcccggtcg tcttccacgg gtacggccag accgagaccg gcatgatctc catggccacc
    14761 cccgaggacg tgcccggttc gctgggcgtg ccgccggtcg agctggcggt acgggacgcc
    14821 gacggccgcc ccgtactgcc cggcaccgac ggcgagctct tcgtccgcac cccggggcag
    14881 agcaccggct actggcagga accggccctg accgccgagg tgttcgtcga cggctgggtg
    14941 cgcacccgcg acatcggccg gctcgacggc gagggccggc tgtggctcac gggacgcgcc
    15001 cgcgacgtga tcatcgtcaa cgccaacgtg tactacgcag gccccgtcga gcgcctgctc
    15061 gccacccacc cgtcggtggc cgaggcgtac gtcgtcgccg tccccgacga cagcaccggg
    15121 gaggccgtgc acgcgttcgt cgtgcccgcc gccggtcggg tcccctccct cggtgagctg
    15181 cgcaggctgg tggcggcgga cctgggcgag gcgtgcgcgc cgacccgtct caccctcatc
    15241 gaggaggtac cgctcacgcc cgcgggcaag cccgacaagc ggcggctcgc cgccggggcc
    15301 tgatccggcc gggccagcga tcaacccaca acggcgatcc acccgaaacg gcgatccgcc
    15361 tgcaacggcc cggccccacc gtcatgccga acgtgacggt ggggccgggt cgctccgggc
    15421 cgttcggcgt ctcagtggct ctcgaccgcg acggccgggg ccgggcgcgc accgtcgccc
    15481 cgtgtccccg tccgcgtccg ctcccgccgg tcgatccacg acagcagcgg tgtcgccatg
    15541 acggtggtga cgacggcgac cacgaccagg gcgctgaaca tcgcctgggt gacgatgccc
    15601 gccgccagac cgagattgag cgcgatcagc tgcatcaggc cccgcgcgtt catcagcgca
    15661 ccgacccgca gcgccacctg gttcggctcg ccggcggcgc gggcggcgag ccagcaggcg
    15721 ccgaacttcc cggcgaccgc gaacagcacg caccccgcgg tgaacagcag caccggtccg
    15781 gaacccagca gggtgaagtc ggtgttcagc ccggagtagg tgaagaacag cggcaggaac
    15841 accgtaccga ccggcttgag cgtctccacc gtgcggtcga gctgctgcga acgcgggaag
    15901 accagtccga ggcagaacgc gccgaacacc gcgtacagtc cggtctcgtc cgtgtaccag
    15961 gccaccagga agagcgcgcc gaccagcgtc agcagcaggc tgtccggcgt gacccggtcg
    16021 gcgagcagcg tggtacggcc gtgcaggcgc accacgccca ccatgaccag gacgagtccg
    16081 aacccgcccg cgacggccag ggacaccagc ccggcactgc cgccggcgat gctgaacacc
    16141 ccggcgagca ggatccacgc gaccgcgtcg tcgacggagc cggcgccgag cgcgagcgac
    16201 ccgtaccggg tgcccgtcag gccccgttcg gcgatgatgc gggccagcat ggggaacgcc
    16261 gtcaccgcca gcgcgacccc gacgaacagg gccgacacca gcaggggcac gtcctcggcc
    16321 agggcgccgg tccgctcgcc gacggcgtag atcagcagca cgccgagcag caccggtacg
    16381 accacgcccg cggcggagac cagcccggcg ggccgggcga ccccgcgcag ccggtccact
    16441 cggaagtccc agccgacgcg gaacatgaac gcgacgagac cgatctgccc caccacgtag
    16501 aggaccggcc gcagttcctg cgggaagagg cccgactcga cgccgggcag cagggcgccg
    16561 agcaccgacg ggcccagcac cacaccggcg atcatctcgc cgacgacggg cggctgcccg
    16621 accgtctgca gcagtcggct gacggcccgg cagacgacca ggatgaccac gacggcgagg
    16681 aagaacttgg gggcgagttc cgcgggggtc atcctctgtt ccctccctgg tgggcgaccg
    16741 ggcagcggcc ggccggagac tcctcgaaat aacgttccgc cagccgctgc cgacgggcgt
    16801 gcagcaccat gaccgtgccg agcaccaact gccgtacgct ccgcgtgacg tcctccaccc
    16861 cgtcccgcac ccgcacgaac cgccgcagcg cctccgtccg gcgcggctgg ggtgacaggc
    16921 cgcgcgggat cagcagacag ggcgcgcggt gcgggttgga ccgggtgtgc gaggccgtgg
    16981 agtccagccg gaagcggcgc agcacctccc ggaccgcggc ccgcagcacg agcggggaga
    17041 gccgccacgc cgggcagggg cggttcgcgg ccacgccgaa cgggatgaag tgggcgtcct
    17101 tcgcagacag ggtgtcccag cggtccgggt cgaacgcgtc gggccggtcg tatcccgtgg
    17161 cgtggtagcc ggggtagctg aagcacacca cggagcccgc cggcagcgtg gtgtgctcgt
    17221 cgagcggtat cgcgtccgtg gtgatgcggt gcgcgatgcc gaacagcggg tacagccgca
    17281 tcgtctcgtc gagcacgtgc gtgaggtacc ggtcgtcgtc ggggtgcgcc cacacacgct
    17341 gctgcacctc ggggtggcgg gccagggcga gcaggacgtg cgcggtggcc tcggagagct
    17401 gtacgacggc cgtgttgaac atcgtccctt gcaggtagtg cacctgctcc tgcggtgaca
    17461 gcgaggccgg cagctcgtgg ggcacgtcac cggcggcgac ccgctcgcgc aggtacgccg
    17521 tcagccgggc ccggcgcccg gggtgccgca gtccggtgca cttcagggcg ttgatcacgt
    17581 cgtcggcgtg cgcggtgatc agttcccggg cgcgcggcgg gcacggctcc ctgaacacca
    17641 tctcgtagca gaactcggcc caggcgggca tcaccaggtc ccgcagccgg acgaggctga
    17701 tccgggtgtc cggcaccgtg tcgagcaccc gggcgacagc gcggccggcc gccgccgcga
    17761 gctccgccga actcccggcg agcatgcgcc gcgtcgccgc cgccacgtcc tcgtagcgct
    17821 cgccgggctc caggtgctcc tgatggactt ccggccccgg cgacagccag taccagaaca
    17881 ggtcggacag ccccgccccc gcgctccgcc cgttcgcggc cgggtgcgcg tacacgcgct
    17941 cgaagacatc cggcccgtgc gcggcgtcgg gcagggtcac cgtccggtcg ccgttgacct
    18001 tctcgaagat gcgcccgcgc agtgcgacga caccgcgcgg cagccaccac gtgtccgccg
    18061 tggccggctt cgttccgctc ctcaccacgt ctcgctcctc accacgtctc ccccttccgg
    18121 acgaccatgt ccctcgccag atccgtgttc cggcgccctc cgcacagcgc gagcgtgtgg
    18181 tcgtactcgt cgcacagggt cctcaggacg gcccggaccc cggcctctcc ctcggcggcc
    18241 aggccccaca ccgccgggcg tccgacaccg acggccgccg cgccgagcgc cagcgcgacg
    18301 gcgacgtcgc tgccccggcg tatcccgccg tccagcagca ccggcacccg gcccgcgacg
    18361 gcgcgggcga ccgcgggcag gcagtccacg gcggccggta cggcgtcgct ctggcggccc
    18421 ccgtggttgg acacgatcac cccggccgcg ccgtgctcga cggccaccgt cgcgtccgcc
    18481 gggtgcagca cccccttgac cagtacgggc agtgaggtca tgtgcagcag ttcgccgagg
    18541 tcccgccagg agagcgacgg ggacatgggg atgtcggtga gaccgtccgg cggggcgccg
    18601 ggcaggccgc gcatgttctc cgcggcgtag ccgggcggca ggtcggtgaa cccgttgcgc
    18661 aggtccctgg tgtgccggcc gaacaccggc gagtcgacgg tgaccaccag cgccgtgcag
    18721 cccgcccgct cggcgcgccg cacgagcgcc tcggtgacct cccgccgggg gtgcaggtac
    18781 agctggaacc acacggccgg gtcggcggcc gcctcgcggg ccgccgcgac gacgtcggcg
    18841 accgccgtgg tcgcggccgt ccccgtcacc aggacagcgc cctcggccgc ggcggcccgg
    18901 gccgtggccc gctcgccgcc gggatgcagc agccggtgga acgcggtcgg cgcgacgacc
    18961 accggcgccg cccgccgggc acccggcagg tcgacggcgg tgtcccggac ctcgctgccg
    19021 cacagcaccc tcggcaggag ggcgtaccgg tcgaaggccc cctcgttccc ggcgacgacg
    19081 cgttcctcgc ccgccccgcc cgccacgtag tcgtagtgga cggggtccag cgtcttgcgt
    19141 gccgcgtcgt acagggcgcg cagcatcacg gggccaccgg agccaccggg gccaccgggg
    19201 cggccggggc ggccgggttg aggtggtcgg tgaggaaggc gcgcagcggg gcgcggtgga
    19261 cctcctcgct gtcccactcg ttctccaggt tctccgtgag gtggtgctcg gagacgaact
    19321 cgccgccccg gtaccagcgg acgaccgggt gcagatagcg gccgtcgaga ccctgcacgt
    19381 cctgctggga cttgcggccc gcggttacgt cgaaggggtc cacccggtcg tggtccgccc
    19441 cgtactccag ggtgatcacc gcgtgggcgg ccacctcccc gaagtcaccg gcgcgcacgg
    19501 cgtccggcac atggcggacg ggcacctcct cggcgtagcg catcgtgccg tccggggcga
    19561 cgagcaggac gtcgccgagg acggcgaact gctgccacag cgcggaggac cggttgaccc
    19621 gggtgacgac cgcgtcgacg gcccgctcca cggcgtcccc gagctccgcg gccggccagt
    19681 cctcgccgtg atggcgcttg cgcagcgccc ggtgcagtgc gcggaccatg tagcggaagc
    19741 cgtggatgaa gccggtcgtg gacttcttga agtcgggtcc ctgggtgatc gtcccggcga
    19801 agtacaggcc gggcacgttg accgactcgc cgacgggtgt gagggccggg aaacggccgt
    19861 cgacgatcag atccggtacg cagctgtcgt cgaagaccga ggtgtcgaac cggaaaccgg
    19921 tcgcgacgat cacccggtcg tagcggatgt ccttgaccac ctcgtcgacc cgctcgaagg
    19981 cgaccggcac ggagaagccg ccgtccgcgt cccggcggat ctccagcacc cgcccgtcga
    20041 ggagcgcgtt ctgcgacttc agctggtagc tgtccaggaa gttgttgttc accgcgcgca
    20101 gatgcccgac gtagtgggac tgccacgcca gccgcagcga gcccgagccg acgacgtgga
    20161 tgaccgacgc ggtctccatc aggctgtcgg ccgtctcgaa ggctgagttg ccccgcccga
    20221 tgatcagcac ccgctgaccg gtgaaggact ccgggtcggg gtcgaacgtg tcgtagcgtt
    20281 cggcgagttc gatgcccggg acggacggca ggttgggcag ggacaccccg gtggcgatca
    20341 ccagacgccg tgcccgccag gtcttcccgg tgtggtcggt gacggtgaat ccgtcaccgt
    20401 cgccgtcacc gtcgcgggac accttctcca cggcggtgtc gtactccacc cgcgccccgg
    20461 tccgggtggc gaagtccgac aggtagcgga ccatgtcgtc ggccggcggg aagtagcgcg
    20521 ggctgtaccg ggtgaacagc agctcggggt cgtcgctcag cagggagttc cagtccatcc
    20581 gcagccgcag ctccggatcg tcgtacccgg tgtgcacctt gttgatcgag atgagtgtgc
    20641 ggtgccgggg gaaccgggtg aagaaggtgc ccggtccgct gccgcgctcc agtacgacgt
    20701 agtccgcacc gtcacgctcc aggaaggcgg cgagctgtag tcccgccggt cccgctccga
    20761 tgatcaggta gtcgtgcgtc atggcccgga agctatccac ccgttttcag agcgctctga
    20821 gattgcctgt ctacggttcc ggtcgtgctg accaccacgg acaccgtcca gctcaccgcc
    20881 ccaccggacc ccgccgccct ccgccgcgcg gc
//
