LOCUS       NZ_BMVW01000002        25671 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces poonensis strain JCM 4815 sequence02, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVW01000002
VERSION     NZ_BMVW01000002.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces poonensis
  ORGANISM  Streptomyces poonensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 759959)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 137X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650915.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:27:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,577
            CDSs (total)                      :: 7,501
            Genes (coding)                    :: 7,228
            CDSs (with protein)               :: 7,228
            Genes (RNA)                       :: 76
            rRNAs                             :: 1, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 273
            CDSs (without protein)            :: 273
            Pseudo Genes (ambiguous residues) :: 0 of 273
            Pseudo Genes (frameshifted)       :: 96 of 273
            Pseudo Genes (incomplete)         :: 224 of 273
            Pseudo Genes (internal stop)      :: 19 of 273
            Pseudo Genes (multiple problems)  :: 60 of 273
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:46:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 386733
            Orig. end                         :: 412404
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVW01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25671
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25671
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25671
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15671]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15671
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            986..2497
                     /locus_tag="IE242_RS08610"
                     /old_locus_tag="GCM10010365_17740"
     CDS             986..2497
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992310.1"
                     /locus_tag="IE242_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17740"
                     /product="hypothetical protein"
                     /protein_id="WP_189857010.1"
                     /transl_table=11
                     /translation="MSGPLALEPDGTGNDTLSLRLAEERTLALRTVDERALTRRAGKGS
                     GHGAGRGAGRQGDDHTLALRTVHEHTLALRLLPGREQREAVDRLAADLADKAGPAVHPY
                     EIAALLESEGLTGEAIRDQYGHKDLFSLAAAVYDRVPRSFPEPAAPPDPWRPDHVRCLL
                     RGVLFALPGLAHVLTARLWQAGDGVTALVVAGLVSWAWGQALGHRAFLRMAAGRREAGR
                     TLLAGAPLGAVLATGAGVAVAGPGPAALFAAGQSVYLACAGVLLVLARERLLLAALGPL
                     AAGAVVLPWWEPGPGLRVGLPLLSLLGVVAAAGWVLRGTLTAEPAPHAVRPGPLLSLPY
                     GLFGLAAGVLVLVQGRWEPYAVIVLTVSMGPAEWLLYRYRGLSVAALRATSTLRGFRLR
                     SAGILALCLLCYLAPLLPAALLTGAEPLPLLLLAATLWTALLLQAFGTAWPPAAVCLAA
                     ACAAGAVALFRPSPDPALLSLCCAAAAVVLTGWVLFALGRPSAHA"
     gene            2590..3591
                     /locus_tag="IE242_RS08615"
                     /old_locus_tag="GCM10010365_17750"
     CDS             2590..3591
                     /EC_number="4.2.1.47"
                     /NRPS_PKS="Domain: NAD_binding_4 (8-183). E-value: 2.3e-19.
                     Score: 61.4. Matches aSDomain:
                     nrpspksdomains_IE242_RS08615_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468244.1"
                     /locus_tag="IE242_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17750"
                     /product="GDP-mannose 4,6-dehydratase"
                     /protein_id="WP_189857012.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.3e-15, bitscore:
                     50.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.6e-18, bitscore:
                     61.4, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.3e-17,
                     bitscore: 59.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSAPLAAVTGAEGFIGSHLTEALVASGYRVRAMAQYNSFSSYGW
                     LETLPKDVLDEVEIVLGDVRDPGSVRGLAEGADCVYHLAALIAIPYSYRAPHSYVDTNV
                     TGTLNVLEAVRALGTPRLVHTSTSETYGTAQTVPITEDHPINTQSPYAASKAGGDRLAD
                     SYYASFGTPVVTLRPFNTFGPRQSMRAVIPTVIGQLAAGERTITLGDLRPTRDFTFVKD
                     TAQAFLAVGTADAGKVVGRTFNAGTGGEISVGDLVALIGKVMDTEVDVREDAQRVRPAN
                     SEVMRLVADAGRLRTVTGWEPAHSLEEGLAQTVEFFRDPANLARYKTDIYNI"
     aSDomain        2614..3138
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE242_RS08615_NAD_binding_4.1"
                     /evalue="2.30E-19"
                     /label="IE242_RS08615_NAD_binding_4.1"
                     /locus_tag="IE242_RS08615"
                     /protein_end="183"
                     /protein_start="8"
                     /score="61.4"
                     /tool="antismash"
                     /translation="VTGAEGFIGSHLTEALVASGYRVRAMAQYNSFSSYGWLETLPKDV
                     LDEVEIVLGDVRDPGSVRGLAEGADCVYHLAALIAIPYSYRAPHSYVDTNVTGTLNVLE
                     AVRALGTPRLVHTSTSETYGTAQTVPITEDHPINTQSPYAASKAGGDRLADSYYASFGT
                     PVVTLRPFNTFG"
     gene            3659..4372
                     /locus_tag="IE242_RS08620"
                     /old_locus_tag="GCM10010365_17760"
     CDS             3659..4372
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655558.1"
                     /locus_tag="IE242_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17760"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_189857014.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.9e-12, bitscore:
                     42.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAVILAGGKGVRLRPYTTALPKPLVPIGDQHAILEIVLRQLATA
                     GFTRCTLAIGHLGQIIRAYVGDGSQWGLHVDYVTEDSPLGTMGPLLTMRDRLPESFLVM
                     NGDILTDLDYADVLRQHRASGAPLTIATYARTVKIDFGVLTTADSKVVGFTEKPDLDYR
                     VSMGVYGLSRATLDHYTAGLPLGFDELVLDLLRAETPPHAYEFDGYWLDIGRPDDYDRA
                     NAEFTSRKSLLLKGA"
     gene            4381..5325
                     /locus_tag="IE242_RS08625"
                     /old_locus_tag="GCM10010365_17770"
     CDS             4381..5325
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049335.1"
                     /locus_tag="IE242_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17770"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_189857016.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.1e-15, bitscore:
                     50.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVLGYTGYLGGHVVEHLRLLPEIGVLRAGRSPDAVYGVDLAT
                     AGPDRLAETLASAAPDAVINCAGAVGGDPVRLAEVNTRGTAVLCEALRQAAPKARLVHF
                     GSAAEYGLGGKGIRVTESAPTRPLSPYGATKLAGTVTVTTSGLDAVVLRVGNPVGPGAP
                     PSGLPGRVAGLLREAGGDREAVLRLGDLSAYRDFVDARDVARAAVLAATASGPLPRVLN
                     IGGGRAVRVRDLVRTLARLAGYQGRIEEDGGGSARSGDVSWQCSDITAAREALLWRPSY
                     TLVASLAALWSATRAPAAHAETVTAPADGGRVR"
     gene            5322..5984
                     /locus_tag="IE242_RS08630"
                     /old_locus_tag="GCM10010365_17780"
     CDS             5322..5984
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982453.1"
                     /locus_tag="IE242_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17780"
                     /product="spherulation-specific family 4 protein"
                     /protein_id="WP_189857018.1"
                     /transl_table=11
                     /translation="MSLLVPLYVHPAEDPDAWQRLLAAVDRTYAVVVNPASGPGREPDA
                     AFVAAARALRAAGARLLGYVDTGYGERPAGEVAADVVRHRDWYGTDGCFLDRTPAGADR
                     LAGCRRLVRRVRRLGAAPVVLNPGVHPAPGYTRLADLVVTFEGHWSTYVAAYHRPEWTE
                     RHTPERFCHLIYGVPEALVPLAVRTATARGAAVCGPVTGELPNPWAALTPALAETKD"
     gene            5984..6907
                     /locus_tag="IE242_RS08635"
                     /old_locus_tag="GCM10010365_17790"
     CDS             5984..6907
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004942534.1"
                     /locus_tag="IE242_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17790"
                     /product="endo alpha-1,4 polygalactosaminidase"
                     /protein_id="WP_189857020.1"
                     /transl_table=11
                     /translation="MGGRTTRGPGRPGRRTSRVGAALVAAVTAAAVAGCAGDGADDEGK
                     ARQSPSATVSASASASTKGSAGSGSSEGAGDLWRPRPGVDWQWQLDGKVDPSVDVPVYD
                     IDGFENSAADVADLHADGRKVICYINVGAYEDWRPDEDDFPESVRGESNGWEGERWLDI
                     RQVSVLRPIMERRFDMCREKGFDAVEPDLMEGYADDTGFPLTAEDQLTYNRMIADIAHE
                     RGLAVGLKNDLPQIPELVDDFEFAVNEECAEFGECEELTPFIEAGKAVFHVEYREPTES
                     FCAESRELKLSSMRKKLGLGVWRDPC"
     gene            complement(6930..8489)
                     /locus_tag="IE242_RS08640"
                     /old_locus_tag="GCM10010365_17800"
     CDS             complement(6930..8489)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606406.1"
                     /locus_tag="IE242_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17800"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_189857022.1"
                     /sec_met_domain="DAO (E-value: 8.7e-10, bitscore: 34.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPRDPRAAARRGRDRRAVVVPARPGAPRITGAPPTTAVVGGGI
                     AGLAAATVLAERGVRVTLHEREPVLGGRLAGWPTTLGDGGTVTMSRGFHAFFRQYYNLR
                     GLLRRTDPGLERLTGLPDYPLRHADGLCDGFRRVPRTPPWSALGFVASSPAFGARDLLR
                     MNPVAALPLLDVRVPEVYERLDAVSAQDFLDAIRFPEAARHLAFEVFSRSFFADPRELS
                     AAEMVLMFHIYFLGSAEGLLFDVPAEPFPAALWDPLATYLRGHGADLRTADPVETVSPR
                     ADGGFDVVTERGAHRFDTVVLALDTAGLRALVEGSPRLADAPWRARIARLRNAPPFLVS
                     RLWLDTPVGRHRPGFLGTAGYGTLDNVSVLERWEGEAARWSARTGGSVVELHAYALPED
                     ASRDVEQKRLLEQLHRVYPETRTARVLDERHEWRADCPLFPVGGHAGRPTVRTPDPGLM
                     VAGDLVRTDLPVALMERAATTGFLAANVLLERWGVRGQMLWTVPNRGRGAVLRHLARWG
                     SG"
     gene            complement(<9248..9961)
                     /locus_tag="IE242_RS08645"
                     /pseudo=""
     CDS             complement(<9248..9961)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677064.1"
                     /locus_tag="IE242_RS08645"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTVLRDAELAAAFDHAARGYDLLVAANPGYHAHLRRSVRRLGLPH
                     GGDGLRVLDLGCGTGASTAALAGVLPGAAITAVDASVGILDRAAGKPWPRRVTFVHAPA
                     EGLADAGVRGPFDAVFAGYLFRNTADPDAVLRAVREVLAPRGRLAAHEYTLSGRARHRA
                     TWTAVCRGLVLPVASALGDGRLYRHLWRSVVDFDTADRFADRVRAAGFDRVRVLPLPGW
                     QTGITHTVVARRGHAG"
     gene            complement(10001..11203)
                     /locus_tag="IE242_RS08650"
                     /old_locus_tag="GCM10010365_17820"
     CDS             complement(10001..11203)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670291.1"
                     /locus_tag="IE242_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17820"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_189857024.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 2.6e-104,
                     bitscore: 344.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQADVAIVGAGAAGLSLAHRLARPAATVAGTRPRRLSVVLLEAP
                     PGALRPPRRTWCFWEPEAGPYDAAVTASWRTLRVHCPAGRPLVGDIAPLRYKMIRSDDF
                     EALVAHDLARTRAVRRVEAVVETVQHVDGGAEVLAHDTGGRPVAVRARWVFDSRPLGSL
                     PAARTTLLQHFRGWFVRADRPVFDPRAVELMDFRTPQPEHGLSFGYILPTSTRQALVEY
                     TEFSREVLAPDAYDAALRHYTEQVLGLRELRITSAEHGVIPMTDAPFARQTGPSVFRIG
                     AASGATRPSTGYTFAAVQRQTRAVAAALRAGRRPVPPSGHAVRSRAMDAVLLRALDSGR
                     IDGAAFFSGLFERVPAGRLLRFLDGRTRLHEDIAIGLRTPVRPMLRSAAELPFLPRRPF
                     A"
     misc_feature    11551..11562
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    complement(11552..11565)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            11732..13090
                     /locus_tag="IE242_RS08655"
                     /old_locus_tag="GCM10010365_17830"
     CDS             11732..13090
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998480.1"
                     /locus_tag="IE242_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17830"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_189857026.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-48, bitscore:
                     160.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTEVTGERAQVRFPSDGDGLPVIGGPPVADADLPLPADLRGDP
                     PFPVDVHDLPAVDADVPGAVGRVLARVLAGRVGRARATDAVFARDIAERVARFTLDGGK
                     RTRSCFVWWGLRACGGADAASAEAALRIGAALELVQTCALVQDDVMDGARLRRGRPALH
                     TDIAAQYAPVAPGAGGERFGEAAAILAGDLALAWAEDLVADTVLALAPDAARRVHGVWS
                     AMRTEMVAGQYLDVQGGATSAHRGGTPPAHRTARALRAACLKSALYSVERPLALGAALA
                     GADGATTRALTTAGRYAGLAFQLRDDLQDVFADPRRTGKPSGGDIRSGKPTYLVALARA
                     RAEASGDRRALAVLRRSLGRADLSGAQLARVREVLVGTGARDVVEARIERLAAQALRHL
                     STAVLDPVAEPHLRRLLCAAAGVPAGRGGTRAEPGPGRAGPAPLTVPAPGAGR"
     gene            13087..14637
                     /locus_tag="IE242_RS08660"
                     /old_locus_tag="GCM10010365_17840"
     CDS             13087..14637
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998479.1"
                     /locus_tag="IE242_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17840"
                     /product="phytoene desaturase"
                     /protein_id="WP_189857028.1"
                     /sec_met_domain="DAO (E-value: 1.4e-18, bitscore: 63.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTVRGRTDHVVVVGAGLSGLSAALHLLGAGRRVTVVERDPLPG
                     GRAGLLERGGYRIDTGPTVLTMPHLADEAFAAVGDSLYDRVELIELHPAYRAHFADGST
                     LDVHTDGEAMAAEVERFAGPGEAAGYRRLRSWLERLHRAQMRRFVDSNFDSPLDLLHPD
                     LARLAALGGFGRWEARVGRHLRDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAG
                     VYFPRGGMHALPRAMADAAADAGAELRLGQEVVRLERSGDRVTAVVTHDDERIACDAVV
                     LTPDLPVVYRLLGRAPRRAPRLRYSPSAVVLHAGTDRTWPQLAHHTLSFGAAWHRTFDE
                     LTRTGRLMSDPSLLITRPTATDPDLAPPGRHLHYILAPCPNTEIGPGAAAWGDLAPRYR
                     DGLLAELERRGLAGLASAVEQQCLVTPADWRALGHAAGTPFSAAHTFAQTGPFRPRNLV
                     RGTRNAVLAGCGTTPGVGVPTVLLSGKLAAARITGPPGAARRRTRTRIPPAAMEGTPS"
     gene            14634..15671
                     /locus_tag="IE242_RS08665"
                     /old_locus_tag="GCM10010365_17850"
     CDS             14634..15671
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982462.1"
                     /locus_tag="IE242_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17850"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_189857030.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.6e-118,
                     bitscore: 390.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9.3e-62,
                     bitscore: 204.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVRELDAAGITGPSLRAAYTRCRELNARHGRTYFLATRLLPVER
                     RPSVHALYGFARWADDIVDSLTSATTRQRAAALARLQGDLADGLRTGRSTEPVVVALAD
                     TARRHGIDHRHFADFMASMHRDLEVTDYPTYAELLSYMHGSAAAIGLQMLPVLGTVVPR
                     EEAAPHAAALGVAFQLTNFLRDVGEDLDRGRVYLPADLLAAHGVDRALLTWSRATGRRD
                     RRITHALRAAEDLTRGVYREAAPGLAMLDPVARPCIRTAFVLYAGILDAVAEDGYAAVH
                     RRAVVPRRRRATVAADGLCRLAAARLAARLAARTAGRHPAPVVPAWPPVPPAAPPSRPA
                     RAEAV"
     gene            15668..16672
                     /locus_tag="IE242_RS08670"
                     /old_locus_tag="GCM10010365_17860"
     CDS             15668..16672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324141.1"
                     /locus_tag="IE242_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17860"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_189857032.1"
                     /transl_table=11
                     /translation="MNPGRSPRRTRFPLTLRRGPVPWERQRPTWREARPALIADALKQA
                     QARPSGNWYVVGARRDVRGDRPLGRTVAGREVVLWRDGGGRLVAGPGACPHLGAPLRDS
                     PVRCGTLVCHWHGLALNGEPFAGWEPLPAYDDGVLVWVRLDEAGGEDPSPAPVIPRRPD
                     PSRALTAVYTGVGVCDPEDVVANRLDPWHGAWFHPYSFVDLTVVGSPADEEEGFTVDVS
                     FKVAGRLVVPVRAVFTAPGPRTVVMRITEGEGAGSVVETHATPLGRDARGRPRTAVIEA
                     VVAASDRPGFRAARGLAPLLRPFVRAAAGRLWRDDLAYAERRRHLRSTGRFPG"
     misc_feature    complement(16694..16714)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.76"
                     /tool="antismash"
     misc_feature    complement(16780..16796)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.95"
                     /tool="antismash"
     gene            16902..18584
                     /locus_tag="IE242_RS08675"
                     /old_locus_tag="GCM10010365_17870"
     CDS             16902..18584
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890441.1"
                     /locus_tag="IE242_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17870"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_229858506.1"
                     /transl_table=11
                     /translation="MISPQGRPGGSSGAGVSVGSTWSDAPCPVLVVDRDGGIVEVNDAA
                     RALLPRAADAGRLPEGLPDWLADAHRRMAGGRDAAHADPLSGAIGDRLFDAHPTPSSDG
                     DVVWWLIDDTDRRLAEETLRSEQERAAILSEVSSTLLSSLSLSHCMESTARLAAHHLAD
                     AAVLIAPAQGLSHPVTSALADGPVTLTTRAVDPATVPGLAEALQGFPPVPTRWIDPGAV
                     PSWAIPEGFKGPVGSVIVTPLPGHGIPDGALILLRSDAGPAFTESEDGFARLLAARAGA
                     ALSAARLYDDQARITAVLMRELLPPALGGVHGVEYAGRYRPFQDSERIGGDFYDVHPGA
                     DPSQESLVVLGDVAGKGLDAAVLTGRIRNTLHALLPLAHDHAYVLNLLNAALLRSPEAR
                     FATLVLASARRRGNRVRLRLTSAGHPPPLVLRADGRVEETRTRGDLVGVMPTVSVRTEE
                     TVLAPGETCLLYTDGITEARGGPLGGELYGLERLERDLAGCAGMPAEAVVERVHMLAAQ
                     WLGQGRHDDMAVVAISAPRTGPLAVISGYADPHNARKRQGRNS"
     gene            18581..19675
                     /locus_tag="IE242_RS08680"
                     /old_locus_tag="GCM10010365_17880"
     CDS             18581..19675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019525639.1"
                     /locus_tag="IE242_RS08680"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17880"
                     /product="B12-binding domain-containing protein"
                     /protein_id="WP_189857036.1"
                     /transl_table=11
                     /translation="MTDFGNATADLRKRLWEAVLDGDAYHATDVLHQGLDAGLERETLL
                     LGVIGKVQEKVGREWAANRITVAQEHAATAVNERALTTLVPPAPAPPSAGPNRSRGRGR
                     VAVACVEGEWHAFPARLVAEVLQLRGWQVDYLGPQIPGPHLIAHLHHTQADVALLSTSL
                     PTRLPAAHAMIAACQAVGVPVMVGGRGFGVDGRHAGAVGADRWAPDARAAAAALEAGIA
                     APGPRAARQVVDDLPHLADQEYTMVVKSRSQLIERTLAGLEEHVPAVRHYTDTQRERTA
                     EDYAHIVDFLATALYVDDAGLFTDFLAWTADVLDARSVSARCLVPGLHLLGRQLQDFPR
                     ATILLRHGAAAVAARPDSDPEDSP"
     gene            19672..20055
                     /locus_tag="IE242_RS08685"
                     /old_locus_tag="GCM10010365_17890"
     CDS             19672..20055
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577783.1"
                     /locus_tag="IE242_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17890"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_229858508.1"
                     /transl_table=11
                     /translation="MITPPFEFSLIVTAAADVLTVEVAGELDHQTSDALVRTVVGHLSP
                     GGAAFRRVRLDFGRLTWIDSMGLSALLAVHRHAGAVGVTLHLDSRPGFLERLLTLTGTL
                     DHLTTTVTTTAAAGDPVPEAEAG"
     misc_feature    20149..20163
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.9"
                     /tool="antismash"
     gene            20218..21957
                     /locus_tag="IE242_RS08690"
                     /old_locus_tag="GCM10010365_17900"
     CDS             20218..21957
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921668.1"
                     /locus_tag="IE242_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17900"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_373299481.1"
                     /transl_table=11
                     /translation="MVSPQGSPAGPRGAGTGSPWSDAPCPVLVVDRAGGIVEANDAART
                     VLPDVTGGDGPYENLPDWLTEAHRHMTGGLGATWAEPPSGAIGGRHFEAHPRPGADGDV
                     AWWLIDATDRHLAEETLRREQERAAILSEVSSTLLSSLNVPRCMEVTARLATRHLADAA
                     VLVAPAQGRRHPVTYAQAHGPAVRVTRAVDPATVPGLAEALQGFPPVPTRWIDPGAIPA
                     WAIPEGFEGPVGSVTVTPLPGHGVPAGALILLRSSTVRAFTESENVFARLFAARAGAAL
                     SAARLYTEQAAVTATLMQELLPPALGGVHGVDYAGGYRPAQDSERIGGDFYDVHPGADP
                     SQESLVVLGDVAGKGLDAAVLTGKIRNTLHALLPLAHDHQHVLNLLNAALLTSRHTRFA
                     TLVLVSARHRAGRVRLRLTSAGHLPPLIVRADGRVEESGTRGNLVGAMPAVSVRTEETV
                     LAPGETCLLYTDGITEARGGPLGGELYGVERLKRALAECAGMPAEAVVERVQMLAAQWL
                     GQGRHDDMAVIAISAPRPRPLTVTGGDMHRGHSGNPGRSGRPGEPGVPGDPGTPHERHG
                     RSA"
     gene            21954..23051
                     /locus_tag="IE242_RS08695"
                     /old_locus_tag="GCM10010365_17910"
     CDS             21954..23051
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948555.1"
                     /locus_tag="IE242_RS08695"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17910"
                     /product="B12-binding domain-containing protein"
                     /protein_id="WP_189857643.1"
                     /transl_table=11
                     /translation="MTASGNATAGLRDRLWEAVLDGDAYTAADVLHAGLDDGHDRETLL
                     LDVIGEVQAKVGVEWAADRITVAQEHAATAVNERVIATLTPRGPAGPGAGRTGRGRVTV
                     ACVDGEWHALPARLVAEVLQLRGWQVDYLGAQTPVPHLIAHLHRTDPYAVLLSSSVPTR
                     LPAAHAAITACQAVGVPVMVGGRAFGPDGRYARAFGADRWAADARAAAAALETGFTAPD
                     ATAARQAVDDLPHLTDQEYTMVVQSRPQLVKQTLVDMEERFPALRRYTEAQRERTAEDL
                     AHIVDFLATALYVDDAGLFTDFLTWTAGILEARRVPARSLLVGLDLLGGQLHDFPRATA
                     LLHAGTAAVTARPVRSAPDPEITTE"
     gene            23048..23458
                     /locus_tag="IE242_RS08700"
                     /old_locus_tag="GCM10010365_17920"
     CDS             23048..23458
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016577783.1"
                     /locus_tag="IE242_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17920"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_189857040.1"
                     /transl_table=11
                     /translation="MTTLPPEFGLDVITAPDVLTIEVVGDLDYETSDELLATVADHLTP
                     DPAFQRLRLDFRGLTWIDSMGLSTLLMVHRRTSATGIALTLDNRPGFLQRMLDLTGTLD
                     HFTATAEGEGEAADSGTGTGTGTGTGTGTGTG"
     gene            complement(23489..23836)
                     /locus_tag="IE242_RS08705"
                     /old_locus_tag="GCM10010365_17930"
     CDS             complement(23489..23836)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978015.1"
                     /locus_tag="IE242_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17930"
                     /product="DUF3140 domain-containing protein"
                     /protein_id="WP_268249434.1"
                     /transl_table=11
                     /translation="MTKNEQEGADDRAGTIKEFGDAVNMSPGELEKWLETDESKSVGQS
                     DGGESVGHASGRRIVELKRTKKGDLSDDDVAHMRKVVGYVHRHMAQRPKGDITDTPWRY
                     SLMNWGHDPAK"
     gene            complement(23833..24060)
                     /locus_tag="IE242_RS08710"
                     /old_locus_tag="GCM10010365_17940"
     CDS             complement(23833..24060)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153088.1"
                     /locus_tag="IE242_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17940"
                     /product="DUF2945 domain-containing protein"
                     /protein_id="WP_189857042.1"
                     /transl_table=11
                     /translation="MASDKKLRKGDKVSWKSHGQDVGGKIEKKITERTEAAGRTVDASS
                     EEPQYEVRSDNSGKTAVHKPGALHKKGKSS"
     gene            complement(24191..25216)
                     /locus_tag="IE242_RS08715"
                     /old_locus_tag="GCM10010365_17950"
     CDS             complement(24191..25216)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019067219.1"
                     /locus_tag="IE242_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010365_17950"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_189857043.1"
                     /transl_table=11
                     /translation="MIIDCHGHYTTAPPALAAWRDRQIAGLTDPSAAPARADLRISDAE
                     LRETVETNQLRMMDERGIDLTVFSPRASFMAHHVGDFRTSAEWAAICNELCFRVSSLYP
                     ERFVPAAMLPQSPGVDPATCLPELTRCVEEYGAVALNLNPDPSGGHWTAPPLTDRSWYP
                     VYEKMVEYDIPAMVHVSTSVNPAFHTTGAHYLNADTTAFMQLVQGDLFTDFPTLRLVIP
                     HGGGAVPYHWGRFRGLAMALGKPPLEEHVLGNVFFDTCVYHQPGIDLLLDVVPTKNILF
                     ASEMIGAVRDVDPCTGHHFDDTRRYTEAAALPAEDLAAIQEHNARAVYPRLDALLRRQG
                     R"
     misc_feature    complement(25292..25306)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.7"
                     /tool="antismash"
     misc_feature    25292..25310
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.25"
                     /tool="antismash"
     misc_feature    25293..25306
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.71"
                     /tool="antismash"
     misc_feature    25294..25307
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.9"
                     /tool="antismash"
ORIGIN
        1 tgcgcccgct ggccgcggac ccgccggcgg aaggcgtggc gcacgcggtc agcggcggcg
       61 tcgccgtgct gccgggcctg accggcctgc aacggcacgg cgtccccctg ctgttgacag
      121 aacacggcgt ctacctgcgg gaacgctatc tgggatatcg caccggcccg taccggtggc
      181 ccgtcaaggc ggtcgtcctc ggcttcttcc ggctgctggc ggaggagacc taccggcggg
      241 ccgcgctgat caccccgggc aaccggtaca accggctgtg ggaggaggag ggcggggccg
      301 acccccggct gatccgtacc gtctacaacg gcgtcgatcc cgcggcgttc cccccggccg
      361 ggcccgagcc cgaggtgccc accctgagct gggccggccg cgtcgacccg atcaaggacc
      421 tggagacgct gatccgcgcc ttcgccgtcg tccgggagaa ggtgcccgag gcgcggctgc
      481 ggctgttcgg cggcactccg cgcggcggcg aggcgtaccg ggagcgctgc gaggcgctgg
      541 ccgacgggct gggccacggc gacgcggtca cgttcgaggg ccgggtcgac gacatcaagg
      601 acgcgtacgc cgccgggaac gtcgtgatgc tctccagcat cagcgagggc ttccccttca
      661 ccctgatcga ggccatgtcc tgcgggcggg ccaccgtctc caccgatgtg ggcggggtcc
      721 gggaggccgt cggcgacacc ggactcgtcg taccgccgcg cgacccggcc gccatggccg
      781 ccgcggccct ggagctgctg gacgacgcgg agcgccggcg gcggatgggc gaggcggccc
      841 ggctgcgggt gatcgagcag ttcacgctgc ggcagaccgt cgactccttc cgctccgtct
      901 atctggagct ggcggccggg ggccggacgc cggacgacag tacgtggccg gaggccggcg
      961 cggaggaact ggggagcgtg gccggatgag cgggccgctg gccctggagc ccgacggcac
     1021 cgggaacgac acactgtccc tgcggctggc ggaggaacgc accctcgccc tgcggacggt
     1081 ggacgaacgc gcgctcaccc gccgcgcggg caagggctcg ggccatggcg cgggcagggg
     1141 cgcaggccgt cagggggacg atcacaccct cgccctgcgc acggtgcacg agcacaccct
     1201 cgcgctgcgg ctgctgcccg gccgtgagca gcgcgaggcg gtggaccggc tcgccgccga
     1261 cctggcggac aaggcgggtc cggccgtgca cccgtacgag atcgccgcgc tgctggagtc
     1321 ggagggcctg accggggagg cgatccgcga ccagtacggc cacaaggacc tgttctcgct
     1381 cgccgccgcc gtgtacgacc gggtgccccg gagcttcccc gagcccgcgg cgccgcccga
     1441 cccctggcgg ccggaccatg tgcgctgcct gctgcgcggg gtgctgttcg cgctgcccgg
     1501 gctcgcccat gtgctcaccg cacggctgtg gcaggccggg gacggggtga ccgccctggt
     1561 cgtggccggg ctggtgtcgt gggcgtgggg tcaggcgctg ggccaccggg ccttcctgcg
     1621 gatggccgcg ggacgccggg aggcgggccg cacactgctg gcgggcgcgc cgctgggcgc
     1681 cgtcctcgcg acgggggccg gtgtcgcggt cgccggaccc ggtccggcgg cgctgttcgc
     1741 ggccggacag tccgtgtacc tggcgtgcgc cggagtactg ctggtcctcg cccgggagcg
     1801 gctgctgctg gccgcgctcg gcccgctcgc cgcgggcgcg gtggtgctgc cgtggtggga
     1861 accggggccc ggcctgcggg tggggctgcc gctgctgtcg ctgctgggcg tggtcgccgc
     1921 ggccggctgg gtgctgcgcg gcacgctcac cgccgagccc gccccgcacg ccgtccggcc
     1981 ggggccgctg ctctccctgc cgtacgggct gttcggcctg gcggcgggcg tgctggtgct
     2041 ggtgcagggc cgctgggagc cgtacgccgt gatcgtgctg acggtgagca tggggccggc
     2101 cgagtggctg ctgtaccgct accgcgggct gtcggtggcc gccctgcgcg ccacctcgac
     2161 gctgcgcggc ttccggctcc gttccgccgg tatcctcgcg ctctgtctgc tctgctatct
     2221 ggcgcctctg ctgcccgccg cgctgctgac cggtgccgag ccgctgccgc tgctgctgct
     2281 cgcggccacg ctgtggaccg cgctgcttct ccaggcgttc ggcaccgcct ggccgcccgc
     2341 cgcggtgtgc ctcgcggccg cgtgcgcggc gggcgcggtc gccctcttcc gtccctcgcc
     2401 ggaccccgcc ctgctgtcgc tgtgctgcgc ggcggccgcg gtggtcctca ccggctgggt
     2461 cctgttcgcc ctgggccggc cctcggcgca cgcctgaccc cgccgtcaca tcccgctcgc
     2521 cacctcaccc atcacctcgt cgcgtgccgc cgtccggcgg tgcgccatcg accggaagga
     2581 aagcctcagt tgagttccgc accgctcgcc gccgtcaccg gagccgaggg cttcatcggc
     2641 tcccacctca ccgaggcgct ggtcgcgtcc gggtaccggg tgagggcgat ggcgcagtac
     2701 aactccttct cctcctacgg ctggctggag accctgccga aggacgtgct cgacgaggtc
     2761 gagatcgtgc tcggcgacgt ccgcgacccg ggctccgtcc ggggcctcgc cgagggcgcc
     2821 gactgcgtct accacctggc ggccctcatc gcgatcccgt actcgtaccg ggcgccgcac
     2881 agttacgtgg acaccaacgt caccggcacg ctcaacgtgc tggaggcggt ccgcgcgctg
     2941 ggcacgcccc ggctcgtgca cacctcgacg agcgagacgt acggcaccgc gcagaccgtg
     3001 ccgatcaccg aggaccaccc catcaacacc cagtcgccgt acgccgcgtc gaaggcgggc
     3061 ggcgaccggc tggccgacag ctactacgcc agcttcggca ccccggtggt gacgctgcgg
     3121 ccgttcaaca ccttcggtcc ccggcagtcc atgcgggcgg tgatcccgac cgtcatcggg
     3181 cagctcgcgg ccggcgagcg caccatcacc ctcggggacc tgcgccccac ccgcgacttc
     3241 accttcgtca aggacaccgc gcaggcgttc ctcgcggtgg gcacggccga cgccgggaag
     3301 gtggtgggcc gcacgttcaa cgcgggcacc ggcggcgaga tctcggtcgg tgacctggtg
     3361 gcgctgatcg gcaaggtgat ggacacggag gtcgacgtcc gcgaggacgc ccagcgggtg
     3421 cggcccgcga actccgaggt gatgcggctc gtcgcggacg ccggccggct ccgtacggtc
     3481 accggctggg agcccgcgca cagcctggag gagggcctcg cgcagaccgt ggagttcttc
     3541 cgcgacccgg ccaacctcgc ccgctacaag accgacatct acaacatctg acactcattc
     3601 cgcttcacat cactcacgtc acctcacctc acctccacac gtccatgaag gagagcccat
     3661 gcacgcagtg atcctggcgg ggggcaaggg cgtccggctg cggccctaca cgaccgcgct
     3721 gcccaagccg ctggtgccca tcggcgacca gcacgccatc ctggagatcg tgctgcgcca
     3781 gctcgcgacg gccggcttca ccaggtgcac cctcgcgatc gggcacctgg gacagatcat
     3841 ccgagcctat gtgggcgacg gctcccagtg gggcctgcac gtcgactacg tcaccgagga
     3901 cagcccgctg ggcaccatgg gcccgctgct cacgatgcgc gaccggctgc cggagtcgtt
     3961 cctcgtgatg aacggcgaca tcctcaccga cctcgactac gccgacgtgc tgcggcagca
     4021 ccgcgcctcg ggcgccccgc tgaccatcgc cacgtacgcc cgcacggtga agatcgactt
     4081 cggggtgctg accaccgccg acagcaaggt cgtcggcttc accgagaagc ccgacctgga
     4141 ctatcgcgtg tccatgggcg tgtacgggct cagccgcgcc acgctcgacc actacacggc
     4201 cgggctgccg ctcggcttcg acgaactggt cctcgacctg cttcgggcgg aaaccccgcc
     4261 gcacgcctac gagttcgacg gatactggct ggacatcggt cgcccggacg actacgaccg
     4321 ggcgaacgcc gagttcacca gccgcaagtc gctgctgctc aagggagcct gaccaccgtc
     4381 atgcgcgtac tcgtcctggg ctacaccgga tacctcggcg gtcatgtcgt cgagcatctg
     4441 cgtctgctgc cggagatcgg cgtcctccgc gccggccggt caccggacgc ggtgtacggc
     4501 gtcgacctgg ccaccgccgg ccccgaccgg ctggccgaga ccctggcgtc ggcggcgccg
     4561 gacgcggtga tcaactgcgc cggcgccgtc ggcggcgacc ccgtgagact cgccgaggtc
     4621 aacacccggg gcaccgcggt gctgtgcgag gcactgcggc aggccgcgcc caaggcccgg
     4681 ctggtccact tcggctcggc tgccgagtac ggcctgggcg gcaaggggat cagggtgacg
     4741 gagtcggcgc cgacccgtcc cctgtccccg tacggcgcga ccaagctcgc cggcaccgtc
     4801 accgtgacca cgtccgggct ggacgcggtg gtgctgcggg tgggcaaccc cgtcgggccg
     4861 ggcgcgccgc cgagcgggct gcccggccgg gtcgcggggc tgctgcgcga ggcgggcggg
     4921 gaccgggagg cggtgctccg gctcggcgac ctgtccgcct accgcgactt cgtggacgcc
     4981 cgcgacgtgg cgcgggcggc ggtcctcgcg gcgaccgcgt ccgggccgct gccgcgcgtg
     5041 ctgaacatcg gcggcgggcg ggccgtccgg gtccgcgacc tggtgcgcac gctggcccgg
     5101 ctcgccgggt accagggccg catcgaggag gacggcggcg gctccgcgcg ctccggcgac
     5161 gtgtcctggc agtgctcgga catcacggcc gcgcgggagg ccctgctgtg gcggccgtcg
     5221 tacacgctgg tggcgtcgct ggccgcgctg tggtcggcga cgcgggcacc ggccgcacac
     5281 gcggagacgg tgacggcccc ggcggacggc ggccgggtgc ggtgagcctc ctcgtgccgc
     5341 tctacgtcca tcccgccgag gaccccgacg cctggcagcg cctgctggcg gccgtggacc
     5401 gtacgtacgc ggtggtggtc aacccggcga gcggccccgg ccgggagccg gacgccgcct
     5461 tcgtggccgc cgcccgcgcc ctgcgcgcgg ccggtgcccg gctgctcggc tatgtggaca
     5521 ccggctacgg ggagcggccc gccggcgagg tcgcggcgga cgtcgtacgg catcgggact
     5581 ggtacgggac cgacggctgc ttcctcgacc gtacgccggc cggcgcggac cggctggccg
     5641 gctgccgaag actcgtcaga cgggtgcggc gcctcggtgc cgcacccgtc gtactgaacc
     5701 cgggcgtcca tccggcgccc gggtacacgc gcctggccga tctcgtcgtc accttcgagg
     5761 ggcactggtc cacgtacgtg gcggcgtacc accggccgga atggaccgaa cggcacacgc
     5821 cggaacgttt ctgccatttg atctacggtg tacccgaggc gctggtccca ctggccgtgc
     5881 gcaccgccac ggcacgtggt gccgcggtct gcgggccggt gaccggtgaa ctacccaatc
     5941 cgtgggcggc gctgacgccc gcgttggcgg agacgaagga ctgatgggcg gcaggacgac
     6001 gaggggcccg gggcggccgg ggcggcggac gtcacgggtg ggcgcggcgc tggtggcggc
     6061 cgtgacggcg gcggccgtgg ccgggtgcgc cggggacggc gccgacgacg aggggaaggc
     6121 gcggcagtct ccgtccgcca cggtctccgc ctccgcctcc gcctccacga agggatcggc
     6181 ggggtccggc tcgtcggagg gagccggcga cctctggcgg ccacggccgg gagtcgactg
     6241 gcagtggcag ctcgacggga aggtcgaccc gtccgtggac gtccccgtct acgacatcga
     6301 cggcttcgag aactcggccg ccgacgtggc ggatctccac gccgacggcc gcaaggtgat
     6361 ctgctacatc aacgtgggcg cgtacgagga ctggcggccc gacgaggacg acttcccgga
     6421 gtccgtgcgg ggcgagtcca acggctggga gggcgagcgc tggctcgaca tccgccaggt
     6481 gtcggtgctg cggccgatca tggagcgccg tttcgacatg tgccgggaga aaggcttcga
     6541 cgcggtggag cccgacctga tggagggata cgccgacgac accggtttcc cgctcaccgc
     6601 ggaggaccag ctgacgtaca accggatgat cgcggacatc gcccatgaac ggggcctggc
     6661 cgtcggcctc aagaacgatc tgccccagat ccccgagctc gtcgacgact tcgagttcgc
     6721 ggtcaacgag gagtgtgcgg agttcggcga gtgcgaggag ctgacgccgt tcatcgaggc
     6781 gggcaaggcg gtgttccacg tcgagtaccg ggagcccacc gagtcgttct gcgcggagtc
     6841 gcgcgagctg aagctgtcgt ccatgcggaa gaagctcggg ctgggggtgt ggcgggaccc
     6901 ctgctgagcg gcgcgggccg cccggccggt cacccgctcc cccaccgcgc caggtgccgc
     6961 aggacggcgc cccgcccccg gttcggcacc gtccacaaca tctggccacg gacgccccag
     7021 cgctccagga ggacgttggc ggcgaggaag ccggtcgtcg ccgcgcgttc catcagggcg
     7081 accggcagat ccgtccgcac caggtcaccg gccaccatga gccccgggtc cggggtccgt
     7141 acggtgggcc ggccggcgtg gccgcccacg gggaacagcg ggcagtcggc gcgccactcg
     7201 tgccgctcgt cgaggacccg ggcggtacgg gtctccgggt acacgcggtg caactgctcc
     7261 agcaggcgct tctgctcgac gtcgcgcgac gcgtcctccg gcagcgcgta cgcgtgcagt
     7321 tcgaccaccg agccgccggt gcgggccgac cagcgggccg cctcgccctc ccagcgctcc
     7381 aggacgctga cgttgtcgag ggtgccgtag ccggcggtgc cgaggaagcc gggccggtgg
     7441 cggccgacgg gcgtgtccag ccacaaccgg gacaccagga acggcggggc gttgcgcagc
     7501 cgggcgatcc gggcccgcca gggggcgtcg gccagccgcg gggagccttc gacgagcgcg
     7561 cgcagcccgg cggtgtcgag ggcgaggacc acggtgtcga agcggtgggc cccgcgttcg
     7621 gtgacgacgt cgaagccgcc gtccgcgcgc ggggacacgg tctcgacggg gtcggcggtg
     7681 cggaggtcgg cgccgtgccc gcgcagatat gtggcgaggg ggtcccagag cgccgccggg
     7741 aacggttcgg ccggcacgtc gaagagcagc ccctcggccg agccgaggaa gtagatgtgg
     7801 aacatcagca ccatctcggc ggcggacagc tcgcgcggat cggcgaagaa actgcgggag
     7861 aacacctcga acgccaggtg ccgggcggct tcggggaacc ggatcgcgtc caggaagtcc
     7921 tgcgcgctga cggcgtccag ccgctcgtac acctcgggca cccggacgtc gagcaggggc
     7981 agcgcggcga ccgggttcat ccgcagcagg tcgcgggcgc cgaaggcggg actcgacgcc
     8041 acgaagccga gcgcgctcca gggcggggtg cgcggcacgc ggcggaagcc gtcgcacagg
     8101 ccgtccgcgt gccggagcgg atagtcggga aggcccgtga ggcgttccag gcccgggtcc
     8161 gtacggcgca gcaggccacg gaggttgtag tactggcgga agaacgcgtg gaagccgcgg
     8221 ctcatcgtca cggtgccgcc gtcgccgaga gtggtgggcc aaccggccag acgtcctccg
     8281 agaacgggtt cgcgctcgtg cagggtcacg cgcacgccac gctccgccag gaccgtcgcg
     8341 gcggccagcc ccgcgatgcc gccgccgacg acggcggtgg tgggcggggc accggtgatc
     8401 cggggcgccc cgggacgggc cggcaccacc acggcccgcc ggtccctgcc acgccgcgcc
     8461 gccgcccgcg ggtcgcgggg gccggtcatc ggtcgcccgc cggggcggct cggccgtctg
     8521 ccggggtcgt gtggtcgctc cccgccgacg cggctcgacc gtccgtcgga gcggctcggc
     8581 cgtctgccgg ggccgtgtgg tcgcttcccg ccggcgcggg cgggacggtc ctctcactcg
     8641 tcgtcctgtt ccttgtcccg gcgccccggc cgttccccgg cgagagccgg tcacccaccc
     8701 gcgcgaaccc cttgtccgcc ggcgcgagcc agacgcctcc cgcaacggcc gggtcggccc
     8761 tcggagcacc gtggttcacc tcccgagccc cgtggctgct cctcagcgtg gcccggtggc
     8821 tccccggcgc ggcccggtca ctcgccggcg cgacccgatg gccctccggc gcgacccggt
     8881 ggccccccga cgcggcccgg tcactcgccg ggccggtccc actgccggcc gggccggtcc
     8941 caccgccggc catgtcggtc ccgctgccga ccaggtcgct ccggccgccg gccggaccgc
     9001 tgcggacacc tgccggacgg tgcaaggcgt ccgccgacgc ggtccgccaa cccgccgggt
     9061 cggtccggtc gttctccgac gcggtccctc ctacggcccc ggccgggccc gccccgtgcc
     9121 ctgccggacc ggtccggcca cctgccgacg ccgacgggcc gcccaccggc ggaggctcgt
     9181 cacccgccac gaccgcccgg ctgctcccgg cccgaccggc cggggacacg ggccggacgt
     9241 ccgccgggcc cgcgtgcccg cggcgggcca cgacggtgtg ggtgatgccg gtctgccagc
     9301 ccggcagggg caggacccgt acgcggtcga agccggcggc ccggacacgg tcggcgaagc
     9361 ggtccgcggt gtcgaagtcg acgacgctgc gccacaggtg gcggtagagc cgtccgtcgc
     9421 ccagggcgga ggccacgggc aggaccagac cccggcacac cgccgtccag gtcgcgcggt
     9481 gccgggcgcg tccgctgagg gtgtactcgt gcgccgcgag ccgcccccgc ggcgccagca
     9541 cctcgcgcac cgcccgcagc acggcgtcgg ggtcggcggt gttgcggaag aggtagccgg
     9601 cgaagacggc gtcgaacgga ccgcgcaccc cggcgtccgc caggccctcc gcgggcgcgt
     9661 ggacgaaggt cacgcgccgt ggccagggct tgccggcggc ccggtccagt atgcccacgg
     9721 acgcgtcgac cgcggtgatc gcggctccgg gcagtacgcc ggcgagggcg gccgtcgagg
     9781 cgcccgtccc gcagcccagg tccagcacgc gcagcccgtc cccgccgtgc ggcaggccca
     9841 ggcggcgtac ggagcggcgc agatgggcgt ggtagcccgg gttggcggcc acgagcaggt
     9901 cgtagccgcg ggcggcgtgg tcgaacgcgg cggccagctc ggcgtcgcgc agtacggtca
     9961 tcggttctcc gggtggttcc gtcgggcgga tcagggcgga tcaggcgaag gggcggcggg
    10021 gcaagaaggg cagttcggcg gcggagcgga gcatcggccg gacgggggtg cgcaggccga
    10081 tggcgatgtc ctcgtgcagc cgggtgcggc cgtcgaggaa ccgcagcagg cgcccggcgg
    10141 gcacccgttc gaagagaccc gagaagaacg ccgcgccgtc gatccggccg ctgtccaggg
    10201 cccgcagcag tacggcgtcc atggcccgcg aacgcaccgc gtgcccggac ggcggcaccg
    10261 gacgccgtcc ggcgcgcagg gcggcggcga cggcgcgcgt ctggcgctgg acggcggcga
    10321 acgtgtatcc ggtcgagggg cgggtggcgc ccgaggcggc gccgatccgg aacacggagg
    10381 ggccggtctg ccgggcgaac ggcgcgtccg tcatcgggat cacaccgtgc tccgccgagg
    10441 tgatccgcag ctcccgcagc cccagcacct gttccgtgta gtggcgcagg gccgcgtcgt
    10501 aggcgtcggg cgcgaggacc tcgcgggaga actccgtgta ctccacgagg gcctgccggg
    10561 tggaggtcgg caggatgtag ccgaacgaca gcccgtgctc cggctggggc gtgcggaagt
    10621 ccatcagctc caccgcgcgg gggtcgaaga ccggccggtc ggcccggacg aaccagcccc
    10681 ggaagtgctg gagcagcgtg gtgcgggcgg cgggcaggct gcccagcggg cgggagtcga
    10741 acacccagcg ggcccgtacc gcgaccgggc gcccaccggt gtcgtgcgcc agcacctccg
    10801 cgccgccgtc gacgtgctgg accgtctcga cgaccgcctc gacgcgccgg accgcgcggg
    10861 tgcgggcgag gtcgtgcgcg acgagtgcct cgaagtcgtc cgagcggatc atcttgtagc
    10921 gcagcggggc gatgtcgccc acgagggggc ggcccgccgg gcagtggacg cggagggtcc
    10981 gccaggaggc ggtgacggcg gcgtcgtacg ggccggcctc cggctcccag aagcaccagg
    11041 tccgccgggg cggtcgcagt gcgcccggcg gggcctccag caggaccacg gacagccgcc
    11101 ggggccgggt tccggcgact gtggcggcgg ggcgggcgag ccggtgcgcc agggacagac
    11161 ccgccgctcc ggcgcccacg atggcgacat ccgcctgcag cacgatgggt ccctcctcga
    11221 gcgcgcgggc acggtgggtg cctcctcgcc agcatcccgg ctgccgtgcc cgccgggacg
    11281 cggacacgct cggcacggtg cgtacgaccg gccgcgcggt cgccggaccg cacgcgtggc
    11341 tcctcgcggc ggcacgccgt gcgcccgggc tcccggtgcc ggcgcggtcc cgcggggacc
    11401 cccggtgacg gaaccggtcc gtcggcggcc tcacggttcc tttccggtct cccggtcggg
    11461 ccgtcggcaa acccgggcgg gcgcatgttg cgtcgtttgc ggtcccgcgg ggtcacgcgt
    11521 acgtgcggta cggcgtcaca cgcaccttcc ggaaatgaac gtttactccc cgtgctgcga
    11581 ggctacccag ggcccgggac ttcgtccccc atggtcaact cgtacccatt cgcgccgttt
    11641 cttcgggggc accgtgacac acgtacgcga cgaggcccgc cttccgtcgc ccggaggagg
    11701 ccggccgccg gccacgacga aaggaaccgg gatgcgttcc accgaggtca ccggagagcg
    11761 cgcgcaggta cggttcccct cggacggcga cggcctgccg gtcatcggcg gtccgccggt
    11821 cgccgacgcg gacctgccgc tgcccgcgga cctccgcggg gacccgccgt tccccgtcga
    11881 cgtccacgac ctgcccgccg tcgacgccga tgtgccgggc gccgtgggcc gcgtcctggc
    11941 ccgggtgctc gccgggcgcg tcggccgggc ccgggcgacg gacgcggtgt tcgcccggga
    12001 catcgccgag cgcgtcgcgc ggttcacgct cgacggcggc aagcgcaccc ggtcctgttt
    12061 cgtgtggtgg ggactgcgcg cctgcggggg cgcggacgcc gcgtccgccg aggcggcgct
    12121 gcggatcggc gccgccctcg aactcgtcca gacgtgcgct ttggtgcagg acgacgtgat
    12181 ggacggggcc cggctgcgcc gcggccggcc ggccctgcac acggacatcg ccgcccagta
    12241 cgcgccggtc gccccggggg cgggcggcga gcggttcggc gaggccgccg cgatcctcgc
    12301 cggggacctc gcactcgcct gggcggagga cctggtcgcc gacaccgtcc tcgccctcgc
    12361 cccggacgcc gcccgccggg tgcacggcgt ctggagcgcc atgcgcaccg agatggtggc
    12421 cgggcagtac ctggacgtcc agggcggggc gacctcggcg caccgcggcg ggacaccccc
    12481 cgcccaccgc acggcccggg cgctgcgggc cgcctgcttg aagagcgcgc tgtactccgt
    12541 ggagcggcca ctggcgctgg gcgcggccct cgccggtgcc gacggcgcca cgacccgggc
    12601 cctcaccacg gccgggcggt acgccgggct ggccttccag ctccgcgacg acctccagga
    12661 cgtgttcgcg gatccgcgcc gtacgggcaa accgtcgggc ggcgacatcc gcagcggcaa
    12721 acccacctac ctcgtggccc tcgcccgggc ccgcgccgag gcgtccggcg accgccgtgc
    12781 cctggccgtg ctgcggcgct cgctcggccg ggccgacctg tccggcgccc agctggcgcg
    12841 cgtccgggag gtgctcgtcg gcaccggcgc ccgggacgtc gtcgaggccc gtatcgagcg
    12901 cctggccgcg caggccctgc ggcacctgtc cacggccgtg ctcgaccccg tggcggagcc
    12961 gcacctgcgg cggctgctgt gtgccgcggc cggtgtcccc gccgggcggg gcggcacccg
    13021 cgcggagccc ggacccggcc gggccgggcc ggcgccgctc accgttccgg ccccgggggc
    13081 gggacggtga cccgtaccgt gcgcgggcgc accgaccacg tcgtggtggt cggcgccgga
    13141 ctgtccggtc tgtcggccgc cctgcatctg ctcggcgcgg gccgccgggt caccgtcgtc
    13201 gagcgcgacc cgctgccggg cggccgggcc ggcctgctgg aacgcggcgg gtaccgcatc
    13261 gacaccggcc ccaccgtgct gaccatgcct catctcgcgg acgaggcctt cgccgcggtc
    13321 ggcgacagcc tgtacgaccg ggtcgagctg atcgagctgc accccgccta ccgggcgcac
    13381 ttcgccgacg gcagcaccct cgacgtgcac acggacggcg aggcgatggc cgcggaggtc
    13441 gaacgcttcg ccgggccggg cgaggcggcc ggataccgcc ggctgcgctc ctggctggag
    13501 cggctgcacc gggcccagat gcgccgtttc gtcgacagca acttcgactc ccccctggac
    13561 ctgctccatc cggacctcgc ccggctcgcc gcgctcggcg gcttcggccg gtgggaggca
    13621 cgcgtcggcc gccatctgcg cgacgagcgg ctgcggcgcg tcttctcctt ccaggcgctg
    13681 tacgcgggcg tgcccccggc ccgcgcgctg gccgcgtacg cggtcatcgc ctacatggac
    13741 accgtggccg gtgtgtactt cccgcgcggc ggcatgcacg cgctgccgcg ggccatggcg
    13801 gacgcggcgg ccgacgcggg ggccgagctg cgcctcgggc aggaggtggt gcggctggag
    13861 cgttccggtg accgggtgac ggcggtagtg acgcacgacg acgaacggat cgcctgcgac
    13921 gccgtcgtgc tgacccccga tctgccggtc gtctaccggc tgctgggccg cgcgccccgc
    13981 cgggcaccgc gcctgcggta ctccccgtcg gccgtggtgc tgcacgccgg caccgaccgg
    14041 acctggccgc agctcgccca ccacacgctg tcgttcggcg cggcctggca ccgcacgttc
    14101 gacgaactga cccgcaccgg ccgcctgatg agcgatccgt ccctgctcat cacccgcccc
    14161 accgcgacgg atccggacct cgctcccccg ggccgccacc tccactacat cctcgcgccg
    14221 tgccccaaca ccgagatcgg tccgggcgcc gccgcctggg gcgacctcgc gccgcgctac
    14281 cgcgacgggc tcctcgccga gctggagcgc cgtgggctgg cgggcctcgc ctcggccgtc
    14341 gagcagcagt gcctggtcac cccggcggac tggcgggccc tggggcacgc ggccggcacg
    14401 ccgttctcgg cggcccacac cttcgcccag accggcccgt tccggccgcg gaacctggtc
    14461 cgcggcacgc ggaacgccgt cctcgccggc tgcggcacca cccccggcgt cggcgtaccg
    14521 acggtgctgc tctccggcaa gctggccgcc gcccgcatca ccggcccgcc cggcgccgcc
    14581 cgccgccgta cccgcacccg catccctccc gcagcgatgg aaggaacccc ctcatgaccg
    14641 tgcgcgaact ggacgcggcg ggcatcaccg gtccgtcgct ccgcgcggcc tacacacggt
    14701 gccgcgagct caacgcccgg cacggcagga cctacttcct ggccacccgg ctgctgcccg
    14761 tggagcgccg cccgtccgtg cacgccctgt acgggttcgc ccgctgggcc gacgacatcg
    14821 tcgactccct caccagcgcg accacccgcc agcgcgccgc cgcgctggcc cggctccagg
    14881 gcgacctggc cgacgggctg cgcaccgggc ggagcaccga gccggtggtc gtcgcgctcg
    14941 ccgacaccgc ccggcgccac ggcatcgacc accggcactt cgccgacttc atggcgtcca
    15001 tgcaccgcga cctggaggtc accgactacc cgacgtacgc cgaactgctc tcctacatgc
    15061 acggttcggc cgccgcgatc gggctgcaga tgctgccggt gctgggcacg gtggtcccgc
    15121 gcgaggaggc ggccccgcac gcggcggccc tcggcgtggc cttccagctc accaacttcc
    15181 tgcgggacgt cggcgaggac ctggaccgtg gccgtgtcta tctgcccgcc gacctgctgg
    15241 ccgcgcacgg cgtggaccgc gcgctgctga cgtggagcag ggccaccggc cgccgcgacc
    15301 ggcggatcac ccacgccctg cgggcggccg aggacctcac ccgcggcgtc taccgcgagg
    15361 ccgcgcccgg tctcgcgatg ctggacccgg tggcccggcc gtgcatccgg accgcgttcg
    15421 tgctgtacgc gggcatcctc gacgccgtcg ccgaggacgg gtacgccgcg gtgcaccgcc
    15481 gcgccgtcgt accgcgccgg cgccgtgcga cggtcgccgc cgacggcctg tgccgcctcg
    15541 ccgccgcccg tctggccgcc cgtctggccg cccgcaccgc cggccggcac cccgcaccgg
    15601 tcgtcccggc gtggcctccc gtcccgccgg ccgccccgcc gtcccggccc gcccgcgcgg
    15661 aggccgtgtg aaccccggac gttccccccg ccgtacccgc ttccccctca ccctgcgccg
    15721 cgggcccgtg ccctgggagc ggcagcggcc gacgtggcgc gaggcccggc ccgcgctgat
    15781 cgcggacgcg ctgaagcagg cgcaggcacg gccgtcgggc aactggtacg tcgtcggcgc
    15841 ccgtcgtgac gtacgcggcg accggcccct gggccggacc gtggccggcc gggaggtggt
    15901 gctctggcgg gacggcggcg ggcggctcgt cgccggaccg ggtgcctgcc cgcacctcgg
    15961 cgcaccgctg cgcgacagcc ccgtacgctg cggcacgctc gtgtgccact ggcacggact
    16021 ggccctgaac ggcgagccgt tcgccgggtg ggagccgctg cccgcgtacg acgacggggt
    16081 cctcgtctgg gtccggctcg acgaggccgg gggcgaggac ccgtcaccgg ctcccgtgat
    16141 cccccggcgg cccgatccgt cccgcgcgct gacggcggtc tacaccggtg tcggggtgtg
    16201 cgatcccgag gacgtcgtcg ccaaccggct cgacccctgg cacggtgcct ggttccaccc
    16261 ctactccttc gtcgacctca ccgtcgtcgg ctcgcccgcg gacgaggagg agggcttcac
    16321 cgtcgatgtc tcgttcaagg tcgccgggcg gctggtcgtg ccggtgcggg cggtgttcac
    16381 cgctccggga ccgcgcacgg tcgtcatgcg catcaccgag ggggagggag cgggctcggt
    16441 cgtcgagacg cacgccacgc cgctcggccg ggacgcccgg ggccggcccc ggaccgcggt
    16501 gatcgaggcc gtcgtggccg cctccgaccg gcccggtttc cgcgccgccc ggggcctggc
    16561 gccgctgctg cgccccttcg tgcgcgccgc cgcgggccgc ctgtggcgcg acgacctggc
    16621 ctatgccgaa cgccgccggc acctgcgctc gacgggacgt ttccccggct gagacggcgg
    16681 cccgatcggc gaaggatcgt ctccgcgacg aacacggcgg cgaaccggtc aagaaccgct
    16741 tctcactgcg acgcaagacg ggcagaaaac gcccgacaca cgtgacattc gttcgactcc
    16801 gaagctcacg tgcatcaggt cacgcccctg cgagacggtt gccgcgagac aacgctcgac
    16861 gtgcagagag gcggtggggt gcggtacgcg cgcctcctct tgtgatctca ccccagggtc
    16921 gtcccggcgg ctccagcggt gccggcgtca gcgtcggctc gacgtggagc gacgccccct
    16981 gccccgtcct ggtcgtggac cgggacggcg gcatcgtcga ggtgaacgac gccgcccggg
    17041 cgctgctgcc ccgggcggcg gatgccggcc ggctccccga gggcctgccg gactggctgg
    17101 cggacgcaca ccggcgcatg gccggcggcc gcgacgccgc acacgcggat ccgctgtccg
    17161 gcgccatcgg tgaccgtctg ttcgacgccc accccacacc gagctcggac ggggacgtgg
    17221 tgtggtggct gatcgacgac accgaccgcc gcctggccga ggagacgctg cgcagcgagc
    17281 aggaacgcgc ggcgatcctc tccgaggtgt ccagcacgct gctgtcgtcg ctgagcctgt
    17341 cgcactgcat ggagtcgacg gcgcgcctgg cggcgcacca cctcgccgac gccgccgtcc
    17401 tcatcgcccc cgcccagggc ctcagccatc cggtcacctc cgcgctggcc gacggccccg
    17461 tcaccctgac cacgcgcgcg gtcgacccgg cgacggtgcc cggactggcc gaggcgctcc
    17521 agggcttccc gcccgtgccg acccggtgga tcgaccccgg cgccgtcccc tcctgggcga
    17581 tccccgaggg gttcaagggc ccggtcggct ccgtcatcgt caccccgctg cccggccacg
    17641 gcatccccga cggcgcgctg atcctgctgc gctccgacgc cgggccggcc ttcaccgaga
    17701 gcgaggacgg cttcgcccgg ctgctcgccg cccgcgccgg tgccgccctg tccgcggccc
    17761 gcctgtacga cgatcaggcc cgtatcaccg cggtcctgat gcgggaactg ctgcccccgg
    17821 cgctcggcgg cgtccacggc gtggagtacg ccggacgcta ccggcccttc caggacagcg
    17881 agcggatcgg cggcgacttc tacgacgtgc accccggcgc cgacccctcc caggagtcgc
    17941 tcgtcgtcct cggggacgtg gcgggcaagg gcctggacgc cgccgtgctg accggcagga
    18001 tccgcaacac gctgcacgcc ctgctgcccc tcgcccacga ccacgcctat gtcctcaacc
    18061 tgctgaacgc cgcgctgctg aggtcccccg aagcgcggtt cgccacactg gtcctcgcct
    18121 cggcgcggcg gcgtgggaac cgggtgcggc tgcggctgac cagcgcgggc caccccccgc
    18181 cgctcgtcct ccgtgccgac ggccgggtgg aggagacccg gacgcgcgga gacctggtcg
    18241 gcgtgatgcc gaccgtgtcg gtacggaccg aggagacggt cctcgccccc ggggagacct
    18301 gtctgctcta caccgacggc atcaccgagg cccgcggcgg gccgctcggc ggtgagctgt
    18361 acggcctgga gcggctcgaa cgggacctgg cggggtgtgc cggcatgccg gcggaggcgg
    18421 tggtggagcg cgtgcacatg ctggccgcgc aatggctggg ccagggccgc cacgacgaca
    18481 tggcggtggt cgccatcagc gcgccgcgaa ccggtccgct ggcagtgatc agcggatacg
    18541 ccgacccgca caacgcgaga aagcgccaag ggagaaactc atgaccgact tcggcaatgc
    18601 cacagccgat ctccggaagc ggctgtggga agccgtcctc gacggagacg cgtaccacgc
    18661 caccgacgtt ctgcaccagg gcctcgacgc cggtctggag cgggagacgc tcctgctggg
    18721 cgtcatcggc aaggtccagg agaaggtcgg ccgcgagtgg gcggccaacc ggatcacggt
    18781 cgcccaggag cacgcggcca ccgccgtcaa cgagcgggcc ctcaccacgc tggtcccgcc
    18841 cgctccggcg cccccgtcgg ccggcccgaa ccggagcagg gggaggggcc gggtggccgt
    18901 ggcctgcgtg gagggcgaat ggcacgcctt cccggcccgc ctggtcgcgg aggtcctcca
    18961 gctgcgcggc tggcaggtgg actacctcgg cccccagatc ccgggcccgc atctgatcgc
    19021 ccacctgcac cacacccagg ctgacgtggc gctgctctcg acctcgctgc cgaccaggct
    19081 gcccgccgcc cacgccatga tcgccgcctg ccaggccgtg ggcgtgcccg tcatggtggg
    19141 cggcaggggc ttcggcgtcg acggccgtca cgccggcgcc gtcggcgccg accggtgggc
    19201 gcccgacgcg cgggccgccg cggccgccct ggaggccggg atcgcggccc cgggcccgag
    19261 ggccgcccgt caggtggtgg acgatctccc gcatctggcg gaccaggagt acaccatggt
    19321 cgtgaagtcc cgttcccagc tgatcgaacg gacactggcg ggtctggagg aacacgtccc
    19381 cgccgtacgg cactacaccg acacccagcg tgagcgcacg gccgaggact acgcccacat
    19441 cgtcgacttc ctcgccaccg ctctctacgt cgacgacgcc ggtctgttca ccgacttcct
    19501 cgcctggacc gccgacgtcc tcgatgcgcg gtcggtctcc gcgcggtgcc tggtccccgg
    19561 gctgcatctc ctcgggcggc agctgcagga cttcccacgc gccacgatcc tgctccgcca
    19621 cggggccgcc gccgtggccg cccgccccga ctccgacccg gaggacagcc cgtgatcaca
    19681 ccgccgttcg agttcagcct catcgtcacc gccgcggcgg acgtgctgac cgtcgaggtc
    19741 gccggcgaac tcgaccatca gacgagcgac gcgctcgtcc gtaccgtcgt cgggcacctc
    19801 tccccgggcg gagcggcctt ccgccgcgtg cggctggact tcgggcggct gacctggatc
    19861 gactccatgg gcctgtcggc actgctggcg gtccaccgcc acgccggcgc cgtcggcgtc
    19921 acccttcacc tggacagccg gccgggattt ctcgagcgcc tgctcaccct caccggcacc
    19981 ctggaccact tgaccaccac cgtcaccacc accgcggcag cgggcgaccc ggtgcccgag
    20041 gccgaggcgg gctgacccgc cgtccggcgg cagaccccgg catccgggac gtccggcagg
    20101 ccgggaccgg ctcggaggtg ggttgcatcc gtcggcgagc tgcgagacgg ttgccgtcgg
    20161 acaactttcc aggcgcagag aggtggtggg gtacgcgcca cgcgtgtatc cctgctcgtg
    20221 gtttctcctc agggttcccc cgcaggccca cgcggcgccg gcaccggctc gccgtggagc
    20281 gacgctccct gcccggtgct ggtcgtggac cgggccggcg gcatcgtgga ggccaacgac
    20341 gccgcccgga cggtactgcc cgacgtgacg ggcggcgacg ggccgtacga gaacctgccg
    20401 gactggctga cggaagcaca ccggcacatg accggcggcc tcggggccac ctgggcggag
    20461 ccgccgtcgg gtgccatcgg cgggcgtcac ttcgaggccc atcccaggcc gggcgcggac
    20521 ggggacgtgg cctggtggct gatcgacgcc accgaccgcc acctggccga ggagacgctg
    20581 cgcagggagc aggaacgcgc ggcgatcctc tccgaggtgt ccagcacgct gctgtcgtcg
    20641 ctgaacgtgc cgcgctgcat ggaggtgacc gcccgtctgg cgacccgtca tctcgcggac
    20701 gccgccgttc tcgtcgcccc cgcccagggc cgccgccacc cggtcaccta cgcgcaggcc
    20761 cacggccccg ccgtccgggt cacgcgggcg gtcgacccgg cgacggtgcc cggactggcc
    20821 gaggcgctgc agggcttccc gcccgtgccg acccggtgga tcgatcccgg ggcgatcccc
    20881 gcgtgggcga tccccgaggg gttcgagggc ccggtcggct ccgtcaccgt caccccgctg
    20941 cccgggcacg gtgtccccgc cggcgccctg atcctgctgc gctccagcac cgtcagggcg
    21001 ttcaccgaga gcgagaacgt cttcgcccgg ctgttcgccg cccgcgccgg tgccgccctg
    21061 tccgcggccc gcctgtacac cgaacaggcc gccgtcaccg cgacgctgat gcaggagctg
    21121 ctgcccccgg cgctcggcgg cgtccacggc gtcgactacg cgggcggcta ccggcccgcc
    21181 caggacagcg agcggatcgg cggcgacttc tacgacgtcc accccggcgc cgacccctcc
    21241 caggagtcgc tcgtcgtcct cggggacgtg gcgggcaagg gcctggacgc cgccgtactg
    21301 accggcaaga tacgcaacac gctgcacgcc ctgctgcccc tcgcccacga ccaccagcac
    21361 gtgctgaacc tgctcaacgc cgcgctgctg acgtcccgtc acacccggtt cgccaccctg
    21421 gtgctggttt ccgcgcgcca ccgtgcgggc cgggtgcggc tgcggctgac cagcgcgggc
    21481 catctcccgc ccctcatcgt ccgcgccgac ggccgggtgg aggagagcgg cacccgcggc
    21541 aacctggtgg gcgcgatgcc ggccgtgtcg gtacggaccg aggagaccgt gctcgccccc
    21601 ggagaaacct gcctgctgta cacggacggc atcaccgagg cccgcggcgg gccgctcggc
    21661 ggtgaactgt acggggtcga acgcctgaaa cgggccctgg cggaatgcgc cgggatgccg
    21721 gcggaggcgg tcgtggagcg cgtgcagatg ctggccgcgc agtggctggg ccagggccgc
    21781 cacgacgaca tggcggtgat cgccatcagc gcgccgcggc cccgcccctt gacggtgacc
    21841 ggcggagaca tgcatcgcgg gcactccggg aaccctggac ggtccgggcg ccccggcgag
    21901 ccaggggtcc ccggcgaccc cggtacccca cacgaacggc acgggaggag cgcgtgaccg
    21961 cttccggcaa cgccacggcc ggtctccgtg accggctgtg ggaggccgtc ctcgacggcg
    22021 acgcgtacac cgccgccgac gtcctgcacg cggggctcga cgacggccac gacagggaaa
    22081 cgcttctgct ggacgtgatc ggcgaggtcc aggcgaaggt cggcgtcgag tgggcggccg
    22141 accggatcac ggtcgcccag gagcacgcgg ccaccgccgt caacgagcgc gtcatcgcca
    22201 cgctgacccc gcgcgggccc gccgggccgg gtgcgggccg gaccggccgg ggccgggtga
    22261 ccgtggcctg cgtggacggc gagtggcacg cccttccggc ccgcctggtc gcggaggtcc
    22321 tccagctgcg cggctggcag gtggactatc tcggcgccca gacgcccgta ccgcatctga
    22381 tcgcccatct gcaccgcacc gacccgtacg cggtcctgct ctcctcctcg gtcccgacca
    22441 ggctgccggc cgcccacgcg gccatcaccg cctgccaggc cgtcggtgtg cccgtcatgg
    22501 tcggcggcag ggccttcgga ccggacggcc gctacgcccg cgccttcggc gccgaccggt
    22561 gggcggccga cgcacgggcc gccgcggccg ccctggagac cgggttcacg gccccggacg
    22621 cgacggccgc ccgtcaggcg gtggacgacc tgccgcacct gaccgaccag gagtacacga
    22681 tggtcgtgca gtcccgtccc cagctggtca agcagacgct ggtggacatg gaggagcgtt
    22741 tccccgcact gcgccggtac accgaggcgc agcgcgaacg caccgccgag gacctcgccc
    22801 acatcgtcga cttcctcgcc accgccctct acgtcgacga cgccggcctg ttcaccgact
    22861 tcctcacctg gaccgccggc atcctcgagg cgcggcgggt gcccgcgcgg tccctgctcg
    22921 tcgggctgga cctgctcggc gggcagctcc acgacttccc gcgcgccacc gccctgctcc
    22981 acgccgggac cgccgccgtc accgcccgcc ccgtccgttc cgcccccgac ccagagatca
    23041 ccaccgaatg accacgctgc cccccgagtt cggactcgac gtcatcaccg caccggacgt
    23101 gctgaccatc gaggtcgtcg gcgatctcga ctacgagacc agcgacgaac tcctcgccac
    23161 cgtcgccgac cacctcaccc cggacccggc cttccagcgc ctccgcctgg acttccgggg
    23221 gctgacgtgg atcgattcca tgggcctgtc gacgctgctg atggtgcacc gccgcaccag
    23281 cgccaccggt atcgcgctca cgctggacaa ccggcccggt ttcctccagc gcatgctcga
    23341 tctcaccggc accctggacc acttcaccgc caccgccgaa ggggagggcg aggccgccga
    23401 ctcgggcacg ggcacgggca cgggcacggg cacaggcacg ggcacaggca cgggctgacc
    23461 ggtcagaggc cggtccggct ccgaggtgtc acttggccgg gtcgtggccc cagttcatca
    23521 ggctgtagcg ccacggtgtg tccgtgatgt cgcccttggg ccgctgcgcc atgtgccggt
    23581 ggacataccc gacgaccttg cgcatatggg ccacgtcgtc gtcgctgagg tcgcccttct
    23641 tggtgcgttt gagctcgacg atgcgccgcc cggaggcatg ccccacgctc tctccgccgt
    23701 cgctctggcc cacgctcttc gactcgtccg tctccagcca cttctccagc tcgccgggcg
    23761 acatgttgac ggcgtcaccg aactccttga tcgtcccggc ccggtcgtcg gccccctcct
    23821 gttcgttctt cgtcacgacg acttcccctt cttgtgcaga gctccgggtt tgtgcacggc
    23881 ggtcttcccc gagttgtcgc tgcggacctc gtactgcggc tcctcggacg acgcgtcgac
    23941 cgtccgcccc gccgcctccg tacgctcggt gatcttcttc tcgatcttgc cgccgacatc
    24001 ctgcccatga ctcttccagg agaccttgtc tcccttgcgg agcttcttgt ccgacgccat
    24061 cgtggcccct ttctctcctg ggtcctccgt tccagcgtcg gggcagggcg tgaatgccgc
    24121 atcccgggca ggcgcgccac ggggcaccgg cgggtccggc ggcaccggcc gcggccggct
    24181 gtcccgccgg tcagcgaccc tgacgccgca gcagcgcgtc caagcggggg tagacggccc
    24241 gggcgttgtg ctcctggatc gccgccaggt cctcggcggg gagggcggcg gcctcggtgt
    24301 agcggcgggt gtcgtcgaag tggtggccgg tgcaggggtc gacgtcgcgg accgcgccga
    24361 tcatctccga ggcgaagagg atgttcttcg tcggtacgac gtcgaggagc aggtcgatgc
    24421 cgggctggtg gtagacgcag gtgtcgaaga agacgttgcc caggacgtgc tcctccagcg
    24481 ggggcttgcc gagcgccatc gccaggccgc ggaagcgccc ccagtggtag gggaccgcgc
    24541 cgccgccgtg cgggatgacc aggcgcaggg tcgggaagtc ggtgaacagg tcgccctgca
    24601 cgagctgcat gaacgccgtg gtgtcggcgt tgaggtagtg cgcgccggtg gtgtggaagg
    24661 ccgggttgac gctggtgctg acgtgcacca tcgccgggat gtcgtactcc accatcttct
    24721 cgtagacggg gtaccacgag cggtccgtga gcggcggcgc ggtccagtgg ccgcccgagg
    24781 ggtccgggtt caggttcagc gcgacggcgc cgtactcctc gacgcagcgg gtgagttccg
    24841 ggaggcaggt ggcggggtcg acgcccggtg actgcggcag catggcggcc gggacgaacc
    24901 gctccgggta gagactgctg acgcggaagc acagctcgtt gcagatggcg gcccattcgg
    24961 cggaggtccg gaagtccccg acgtggtggg ccatgaacga cgcgcgcggg gagaagaccg
    25021 tgaggtcgat gccgcgttcg tccatcatcc gcaactggtt cgtctcgacg gtctcgcgca
    25081 gttcggcgtc gctgatgcgc agatccgcgc gcgcgggggc ggccgacggg tcggtgagcc
    25141 cggcgatctg ccggtcgcgc caggcggcca gggccggcgg agcggtggtg tagtgaccgt
    25201 ggcaatcgat gatcatcgct gttcccgggt tccgtgctgt ccctgcggtg cgggggctgg
    25261 aggttctcga ggatcaactt aaccgctgac gaaattgttg acaatatctg ggcggccggg
    25321 agacaaccac gggggcctgc cgcccatgcg acagacgacc cccgtggcgc gtaccgcgta
    25381 caccggtgcc gtcagtcccg ccgccaggac tccgggtccc atacccccga gcgccgcagg
    25441 gaggccggac agtgaaggta gatctcgtcg atgtcgagga gcagcgcgag cagcggacgg
    25501 cgccccgccg ccgccatgtc gtcgaagaaa ggcgcgtcgg tcaggatgcg ggcgcggccg
    25561 ttcacacgca gtacttcttt gctgccggga atgagataga gaagcccggc gtgcgggttg
    25621 tcgaggatgt tctggaagct gtcgccgcgc cggttgcccg ggcggtcggg c
//
