LOCUS       NZ_BMVR01000046         7730 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence46, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000046
VERSION     NZ_BMVR01000046.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 7730)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7730
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000046.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..7730
                     /culture_collection="JCM:4753"
                     /db_xref="taxon:68200"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces flavofungini"
                     /strain="JCM 4753"
                     /submitter_seqid="sequence46"
                     /type_material="type strain of Streptomyces flavofungini"
     gene            <1..>7730
                     /locus_tag="IE274_RS38965"
     region          1..7730
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..7730
                     /SMILES="NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7730
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[4:>7730](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5..>7730
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             5..>7730
                     /NRPS_PKS="Domain: PCP (1-52). E-value: 1.7e-19. Score:
                     61.8. Matches aSDomain: nrpspksdomains_IE274_RS38965_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (68-370). E-value:
                     3.7e-109. Score: 356.3. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (535-932). E-value: 1.3e-96.
                     Score: 315.6. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1049-1114). E-value: 2.2e-21.
                     Score: 67.9. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1136-1452). E-value:
                     5.2e-129. Score: 423.1. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1466-1628). E-value: 5.8e-38.
                     Score: 122.1. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_TIGR01720.1"
                     /NRPS_PKS="Domain: Condensation_DCL (1637-1939). E-value:
                     3.6e-101. Score: 330.2. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2101-2497). E-value:
                     3.8e-98. Score: 320.7. Matches aSDomain:
                     nrpspksdomains_IE274_RS38965_AMP-binding.2"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638470.1"
                     /locus_tag="IE274_RS38965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_190120690.1"
                     /sec_met_domain="PP-binding (E-value: 1.4e-15, bitscore:
                     43.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 9.5e-73, bitscore:
                     230.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3e-110, bitscore:
                     354.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGVDDNFFTVGGHSLLATRLVSRIRTTLDVEIPIRAVFAAPTVA
                     ELVEHLTGGGSVRARLRRAEPRPERVPLSYAQRRLWFIDRFEGPSATYNTPFPLRLTGT
                     LDAAAFEAAVNDVVTRHESLRTLIIDDGAGVPFQKVLPAADVHVAVPVVDVTPEALDDA
                     VAEAAGHGFDLAGEVPARATVFRCGEDEFVLLLLFHHIVSDGVSMGPLSRDLAAAYTAR
                     LAGTAPDWEELPVQYVDYTLWQRELLGAEDDPESVQSAQVDYWREELAGVPQPLRLPTD
                     RPRPQAASHRGGTVEFALDRDVMDTVEELARRRGATASMVLQCALTVLLHGLGGGDDIT
                     VGAPVAGRTDELLADLVGFFVNTWVLRADLSGNPAFEDLLDQARDKSLAAYDHQDVPFE
                     RLVEVLNPERSTAYAPLFQVMFAWQNFHRNDFALPGLDVRFERIRNESAKFDLFFNMAD
                     IPGHGVVGHLEYATDLFDPASAQGITDRFIRVVGLLAADPAQRVGAVELVEPAERDLVL
                     RDFNDTARPTPVLTVPGLFEEQAARTPEAVAVVDGDSSWTYRELDARAELLACELVRRG
                     VGPEAVVGLALPRSADLVVGLLGVLKAGAAYLPIDPRYPSSRLDHILSDARPRLLLTDA
                     DTVGVLPDSGIPRLFVGDLDLEPEMGDVKVRDLDRVVPLRPDNVAYVMYTSGSTGTPKG
                     VMVTHTNVVNGVTRLAASVGIDSATRMLAATSVNFDVSVFETFATLSQGGTVEVARDVL
                     VIGEGGGWTGGVVSTVPSVFAELLDQVDGELVVDSVVFAGEVLPAALVDRVREAIPGVR
                     VVNAYGQTESFYATTWALPADQEWGGSGSVPIGAPLGNMRAYVLGSGLAPVPVGVVGEL
                     YIAGNVARGYFGRADLTADRFVADPYGPAGSRMYRTGDLARWTPEGQLDYVGRGDAQVK
                     VRGIRIEPGEVEAALAAHPGVAQAVVAVKDGRGGKQLVGYVVPAGEQVEDVNADLDLTA
                     GVPVEELRRFASGRLPEFMVPAVFVVLDRLPLAPNGKLDREALPEPEFTAGEYRAPRTA
                     EEKVLAGVYAEVLGLGRVGVDDDFFAVGGDSIRSIQVVSRAKAQGVETTPRQIFECRTV
                     AELAVAAVENRLAGAGAVLEELAGGGVGWMPLLPVARYLTSELGGNTDRFSMSTVLDLP
                     QGIDEAGLFATLSAVVDHHDVLRSRFRAEGEGGLEVTAPGTVDVAPLVHRVECDGDWDS
                     AAWRRLATAELDAATGRLNPTAGVMAQFVWCDTAGADPAGRLIVVLHHLVVDGVSWRIL
                     VPDLAAAWEGVKAGRTPELAPVGTSLRRWSHALKDEANRESRTAELPLWEGMLEGADPV
                     IGSRPLDPAVDVTATVETVSVQLPVAVTESLLTTVPAAFHGGVDDGLLAALALAVSRWR
                     GERGVPESSASSTLIRLEGHGRAEHVAPGADVSRTLGWFTSMFPVRLDVAGHDVAEAFA
                     GGRAAGGVVKAVKEQLLSVPDKGIGFGLLRYLNPETSRALAGRPTGQIAFNYLGRFSAD
                     DMPEALRGLGWTTAPDTDALIADLDAEMPALATVDFTAYVTDSAQGPELTASVGFPTGV
                     LTRDEVRRLADLWCAALDGLTRHAAEPDAGGLTPSDVPLVTVEQSDIEAWEEKYPGVSD
                     VWPLTTMQSGLLFHSLLGARDAEGPADARDAYHIQLVMHLSGQIDPARVRKAGQALLDR
                     YANLRAAFVPDSAGELVQLIVDGAELPWSQADFSALPEGERAEALERLLAEDQVTPFDP
                     AAAPLLRMCLVTMGDNLSELVFSAHHVLYDGWSFPMLVQDLLRLYGSHGDPAELPRVRG
                     YREFLAWLSQQDRGEAARAWARELDGVAEPTMLAPGASAEQGGLDMVEVPLPTEDARAL
                     SRRAAELGITLNTLVQGAWALALGQLTGRQDVTFGATVSGRPPSVTGVDTMVGLFINTL
                     PVRVAAEPGQTLAQLLTGLQDRQAALLDHHHYGLSDIQRATGLGTLFDTLVVFESFPVD
                     HAGMSDANAAAGIAVTGLRASSGTHYPLIVGADASPHLRLGLQYQDTRYDKDTVKGIAG
                     RLGRVLQQIAADPETPVKDVDVLAPEERQRLLVAFNDTARPTPALTVPGLFEEQAARTP
                     EAVAVVDGDSSWTYRELDARAELLARELVRRGVGPEAVVGLALPRSADLVVGLLGVLKA
                     GAAYLPIDPRYPSSRLDHILSDAAPKLLLTDADTVGVLPETDIPRLFLGAVDLEPAATD
                     APLTDADRRAALKPDHIAYVMYTSGSTGTPKGVAVTHANVVNGVTRLVERVGGAGSRML
                     AGTSVNFDVSVFETFTTLSTGGTLEVVRDVLVIGERGGWSGGVVSTVPSVFAEILDQVD
                     GELVVDSVVFAGEALPAALVDRVREAIPGVRVVNAYGQTESFYATTFTLPADQEWTGTG
                     SAPIGTPLGNMRAYILGPTLQPAPESVVGELYIAGNVARGYFGRADLTADRFVADPYGP
                     AGGRMYRTGDLARWNADGQLEYVGRGDAQFKVRGFRIEPGEVEAALAAHPDVAQGVVVA
                     KGTGTTDKRLVAYVVPAGNVEDIDVTALREHVGGKLPEFMVPSAFVVLERLPL"
     aSDomain        10..162
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_PCP.1"
                     /evalue="1.70E-19"
                     /label="IE274_RS38965_PCP.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="52"
                     /protein_start="1"
                     /score="61.8"
                     /tool="antismash"
                     /translation="VGVDDNFFTVGGHSLLATRLVSRIRTTLDVEIPIRAVFAAPTVAE
                     LVEHLT"
     aSDomain        211..1116
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.70E-109"
                     /label="IE274_RS38965_Condensation_LCL.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="370"
                     /protein_start="68"
                     /score="356.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVSDG"
                     /tool="antismash"
                     /translation="ERVPLSYAQRRLWFIDRFEGPSATYNTPFPLRLTGTLDAAAFEAA
                     VNDVVTRHESLRTLIIDDGAGVPFQKVLPAADVHVAVPVVDVTPEALDDAVAEAAGHGF
                     DLAGEVPARATVFRCGEDEFVLLLLFHHIVSDGVSMGPLSRDLAAAYTARLAGTAPDWE
                     ELPVQYVDYTLWQRELLGAEDDPESVQSAQVDYWREELAGVPQPLRLPTDRPRPQAASH
                     RGGTVEFALDRDVMDTVEELARRRGATASMVLQCALTVLLHGLGGGDDITVGAPVAGRT
                     DELLADLVGFFVNTWVLRADL"
     aSModule        211..4890
                     /complete
                     /domains="nrpspksdomains_IE274_RS38965_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE274_RS38965_AMP-binding.1"
                     /domains="nrpspksdomains_IE274_RS38965_PCP.2"
                     /domains="nrpspksdomains_IE274_RS38965_Epimerization.1"
                     /domains="nrpspksdomains_IE274_RS38965_TIGR01720.1"
                     /locus_tags="IE274_RS38965"
                     /monomer_pairings="Leu -> D-Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       277..387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0001"
                     /evalue="9.40E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE274_RS38965"
                     /protein_end="127"
                     /protein_start="90"
                     /score="53.4"
                     /tool="antismash"
                     /translation="ATYNTPFPLRLTGTLDAAAFEAAVNDVVTRHESLRTL"
     CDS_motif       598..663
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0002"
                     /evalue="2.00E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE274_RS38965"
                     /protein_end="219"
                     /protein_start="197"
                     /score="29.9"
                     /tool="antismash"
                     /translation="FHHIVSDGVSMGPLSRDLAAAY"
     CDS_motif       712..750
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0003"
                     /evalue="2.20E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE274_RS38965"
                     /protein_end="248"
                     /protein_start="235"
                     /score="13.9"
                     /tool="antismash"
                     /translation="QYVDYTLWQRELL"
     CDS_motif       1018..1107
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0004"
                     /evalue="5.00E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE274_RS38965"
                     /protein_end="367"
                     /protein_start="337"
                     /score="44.6"
                     /tool="antismash"
                     /translation="DITVGAPVAGRTDELLADLVGFFVNTWVLR"
     CDS_motif       1156..1275
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0005"
                     /evalue="3.10E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE274_RS38965"
                     /protein_end="423"
                     /protein_start="383"
                     /score="77.5"
                     /tool="antismash"
                     /translation="RDKSLAAYDHQDVPFERLVEVLNPERSTAYAPLFQVMFAW"
     aSDomain        1612..2802
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_AMP-binding.1"
                     /evalue="1.30E-96"
                     /label="IE274_RS38965_AMP-binding.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="932"
                     /protein_start="535"
                     /score="315.6"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FEEQAARTPEAVAVVDGDSSWTYRELDARAELLACELVRRGVGPE
                     AVVGLALPRSADLVVGLLGVLKAGAAYLPIDPRYPSSRLDHILSDARPRLLLTDADTVG
                     VLPDSGIPRLFVGDLDLEPEMGDVKVRDLDRVVPLRPDNVAYVMYTSGSTGTPKGVMVT
                     HTNVVNGVTRLAASVGIDSATRMLAATSVNFDVSVFETFATLSQGGTVEVARDVLVIGE
                     GGGWTGGVVSTVPSVFAELLDQVDGELVVDSVVFAGEVLPAALVDRVREAIPGVRVVNA
                     YGQTESFYATTWALPADQEWGGSGSVPIGAPLGNMRAYVLGSGLAPVPVGVVGELYIAG
                     NVARGYFGRADLTADRFVADPYGPAGSRMYRTGDLARWTPEGQLDYVGRGDAQVKVR"
     CDS_motif       1798..1839
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0006"
                     /evalue="2.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE274_RS38965"
                     /protein_end="611"
                     /protein_start="597"
                     /score="17.2"
                     /tool="antismash"
                     /translation="LGVLKAGAAYLPID"
     CDS_motif       2044..2103
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0007"
                     /evalue="1.20E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS38965"
                     /protein_end="699"
                     /protein_start="679"
                     /score="33.2"
                     /tool="antismash"
                     /translation="AYVMYTSGSTGTPKGVMVTH"
     CDS_motif       2596..2682
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0008"
                     /evalue="1.30E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS38965"
                     /protein_end="892"
                     /protein_start="863"
                     /score="43.0"
                     /tool="antismash"
                     /translation="PVGVVGELYIAGNVARGYFGRADLTADRF"
     CDS_motif       2767..2832
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0009"
                     /evalue="7.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS38965"
                     /protein_end="942"
                     /protein_start="920"
                     /score="31.0"
                     /tool="antismash"
                     /translation="YVGRGDAQVKVRGIRIEPGEVE"
     aSDomain        3154..3348
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_PCP.2"
                     /evalue="2.20E-21"
                     /label="IE274_RS38965_PCP.2"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1114"
                     /protein_start="1049"
                     /score="67.9"
                     /tool="antismash"
                     /translation="EKVLAGVYAEVLGLGRVGVDDDFFAVGGDSIRSIQVVSRAKAQGV
                     ETTPRQIFECRTVAELAVAA"
     aSDomain        3415..4362
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_Epimerization.1"
                     /evalue="5.20E-129"
                     /label="IE274_RS38965_Epimerization.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1452"
                     /protein_start="1136"
                     /score="423.1"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDG"
                     /tool="antismash"
                     /translation="MPLLPVARYLTSELGGNTDRFSMSTVLDLPQGIDEAGLFATLSAV
                     VDHHDVLRSRFRAEGEGGLEVTAPGTVDVAPLVHRVECDGDWDSAAWRRLATAELDAAT
                     GRLNPTAGVMAQFVWCDTAGADPAGRLIVVLHHLVVDGVSWRILVPDLAAAWEGVKAGR
                     TPELAPVGTSLRRWSHALKDEANRESRTAELPLWEGMLEGADPVIGSRPLDPAVDVTAT
                     VETVSVQLPVAVTESLLTTVPAAFHGGVDDGLLAALALAVSRWRGERGVPESSASSTLI
                     RLEGHGRAEHVAPGADVSRTLGWFTSMFPVRLDVA"
     CDS_motif       3481..3585
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0010"
                     /evalue="1.20E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1193"
                     /protein_start="1158"
                     /score="14.4"
                     /tool="antismash"
                     /translation="MSTVLDLPQGIDEAGLFATLSAVVDHHDVLRSRFR"
     CDS_motif       3805..3870
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0011"
                     /evalue="3.80E-10"
                     /label="NRPS-E2"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1288"
                     /protein_start="1266"
                     /score="32.0"
                     /tool="antismash"
                     /translation="LIVVLHHLVVDGVSWRILVPDL"
     CDS_motif       4303..4353
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0012"
                     /evalue="3.60E-08"
                     /label="NRPS-E5"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1449"
                     /protein_start="1432"
                     /score="25.5"
                     /tool="antismash"
                     /translation="DVSRTLGWFTSMFPVRL"
     aSDomain        4405..4890
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_TIGR01720.1"
                     /evalue="5.80E-38"
                     /label="IE274_RS38965_TIGR01720.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1628"
                     /protein_start="1466"
                     /score="122.1"
                     /tool="antismash"
                     /translation="GGVVKAVKEQLLSVPDKGIGFGLLRYLNPETSRALAGRPTGQIAF
                     NYLGRFSADDMPEALRGLGWTTAPDTDALIADLDAEMPALATVDFTAYVTDSAQGPELT
                     ASVGFPTGVLTRDEVRRLADLWCAALDGLTRHAAEPDAGGLTPSDVPLVTVEQSDIEA"
     CDS_motif       4423..4485
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0013"
                     /evalue="4.50E-10"
                     /label="NRPS-E6"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1493"
                     /protein_start="1472"
                     /score="31.7"
                     /tool="antismash"
                     /translation="VKEQLLSVPDKGIGFGLLRYL"
     aSDomain        4918..5823
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="3.60E-101"
                     /label="IE274_RS38965_Condensation_DCL.1"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1939"
                     /protein_start="1637"
                     /score="330.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVLYDG"
                     /tool="antismash"
                     /translation="DVWPLTTMQSGLLFHSLLGARDAEGPADARDAYHIQLVMHLSGQI
                     DPARVRKAGQALLDRYANLRAAFVPDSAGELVQLIVDGAELPWSQADFSALPEGERAEA
                     LERLLAEDQVTPFDPAAAPLLRMCLVTMGDNLSELVFSAHHVLYDGWSFPMLVQDLLRL
                     YGSHGDPAELPRVRGYREFLAWLSQQDRGEAARAWARELDGVAEPTMLAPGASAEQGGL
                     DMVEVPLPTEDARALSRRAAELGITLNTLVQGAWALALGQLTGRQDVTFGATVSGRPPS
                     VTGVDTMVGLFINTLPVRVAA"
     aSModule        4918..7497
                     /domains="nrpspksdomains_IE274_RS38965_Condensation_DCL.1"
                     /domains="nrpspksdomains_IE274_RS38965_AMP-binding.2"
                     /incomplete
                     /locus_tags="IE274_RS38965"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4924..4965
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0014"
                     /evalue="2.90E-03"
                     /label="C1_DCL_004-017"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1653"
                     /protein_start="1639"
                     /score="10.2"
                     /tool="antismash"
                     /translation="WPLTTMQSGLLFHS"
     CDS_motif       5008..5124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0015"
                     /evalue="1.30E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1706"
                     /protein_start="1667"
                     /score="46.4"
                     /tool="antismash"
                     /translation="DAYHIQLVMHLSGQIDPARVRKAGQALLDRYANLRAAFV"
     CDS_motif       5347..5409
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0016"
                     /evalue="6.20E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1801"
                     /protein_start="1780"
                     /score="28.3"
                     /tool="antismash"
                     /translation="HHVLYDGWSFPMLVQDLLRLY"
     CDS_motif       5719..5814
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0017"
                     /evalue="5.40E-18"
                     /label="C5_DCL_263-294"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1936"
                     /protein_start="1904"
                     /score="57.4"
                     /tool="antismash"
                     /translation="DVTFGATVSGRPPSVTGVDTMVGLFINTLPVR"
     CDS_motif       5863..5976
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0018"
                     /evalue="1.30E-18"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IE274_RS38965"
                     /protein_end="1990"
                     /protein_start="1952"
                     /score="59.5"
                     /tool="antismash"
                     /translation="QDRQAALLDHHHYGLSDIQRATGLGTLFDTLVVFESFP"
     aSDomain        6310..7497
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38965_AMP-binding.2"
                     /evalue="3.80E-98"
                     /label="IE274_RS38965_AMP-binding.2"
                     /locus_tag="IE274_RS38965"
                     /protein_end="2497"
                     /protein_start="2101"
                     /score="320.7"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FEEQAARTPEAVAVVDGDSSWTYRELDARAELLARELVRRGVGPE
                     AVVGLALPRSADLVVGLLGVLKAGAAYLPIDPRYPSSRLDHILSDAAPKLLLTDADTVG
                     VLPETDIPRLFLGAVDLEPAATDAPLTDADRRAALKPDHIAYVMYTSGSTGTPKGVAVT
                     HANVVNGVTRLVERVGGAGSRMLAGTSVNFDVSVFETFTTLSTGGTLEVVRDVLVIGER
                     GGWSGGVVSTVPSVFAEILDQVDGELVVDSVVFAGEALPAALVDRVREAIPGVRVVNAY
                     GQTESFYATTFTLPADQEWTGTGSAPIGTPLGNMRAYILGPTLQPAPESVVGELYIAGN
                     VARGYFGRADLTADRFVADPYGPAGGRMYRTGDLARWNADGQLEYVGRGDAQFKVR"
     CDS_motif       6496..6537
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0019"
                     /evalue="2.90E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE274_RS38965"
                     /protein_end="2177"
                     /protein_start="2163"
                     /score="17.2"
                     /tool="antismash"
                     /translation="LGVLKAGAAYLPID"
     CDS_motif       6742..6801
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0020"
                     /evalue="5.20E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS38965"
                     /protein_end="2265"
                     /protein_start="2245"
                     /score="31.2"
                     /tool="antismash"
                     /translation="AYVMYTSGSTGTPKGVAVTH"
     CDS_motif       7291..7377
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0021"
                     /evalue="1.70E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS38965"
                     /protein_end="2457"
                     /protein_start="2428"
                     /score="36.3"
                     /tool="antismash"
                     /translation="PESVVGELYIAGNVARGYFGRADLTADRF"
     CDS_motif       7462..7527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38965_0022"
                     /evalue="9.80E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS38965"
                     /protein_end="2507"
                     /protein_start="2485"
                     /score="30.6"
                     /tool="antismash"
                     /translation="YVGRGDAQFKVRGFRIEPGEVE"
ORIGIN
        1 agcgggtcgg cgtcgacgac aacttcttca ccgtcggtgg ccactccctg ctcgcgaccc
       61 ggctcgtcag ccgcatccgc accacgctcg acgtcgagat cccgatccgt gctgtcttcg
      121 ccgcgccgac ggtcgcggaa ctcgtcgagc acctcaccgg cggcggcagc gtccgcgccc
      181 ggctccgccg ggcagagccc cgccccgagc gcgtaccgct gtcgtacgcg cagcgccgcc
      241 tgtggttcat cgaccgcttc gagggcccct cggcgacata caacacaccg ttcccgctgc
      301 gcctgaccgg cacgctcgac gccgccgcgt tcgaggccgc cgtcaacgac gtggtcacgc
      361 ggcacgagag cctgcgcacg ctgatcatcg acgacggtgc gggcgtgccc ttccagaagg
      421 tgctgcccgc cgcagacgtg cacgtcgccg tgcccgtcgt cgacgtgacg cccgaggccc
      481 tcgacgacgc cgtggccgag gccgccggtc acggcttcga cctggccggt gaggtcccgg
      541 cccgggccac cgtgttccgc tgcggcgagg acgagttcgt cctgctgctc ctgttccacc
      601 acatcgtcag cgacggcgtg tccatgggcc cgctgtcccg cgacctcgcc gccgcctaca
      661 ccgcccggct cgcgggcacc gcgccggact gggaggaact cccggtccag tacgtggact
      721 acacgctgtg gcagcgcgag ctgctcggcg ccgaggacga ccccgagagc gtgcagtccg
      781 cgcaagtcga ctactggcgc gaggagctgg cgggcgtgcc ccagccgctc cgcctgccca
      841 ccgaccggcc ccgcccgcag gccgccagcc accgtggcgg cacggtcgag ttcgccctcg
      901 accgggacgt gatggacacc gtcgaggagc tggcccggcg ccgcggcgcg accgcgtcga
      961 tggtgctcca gtgcgccctg acggtgctgc tgcacggcct cggcggcggc gacgacatca
     1021 ccgtcggcgc cccggtcgcg ggccgcaccg acgaactcct cgcggacctg gtcggcttct
     1081 tcgtcaacac ctgggtgctg cgcgccgacc tgtccggcaa ccccgccttc gaggacctgc
     1141 tcgaccaggc ccgcgacaag tccctggccg cgtacgacca ccaggacgtg ccgttcgagc
     1201 gcctggtgga ggtgctcaac ccggagcggt ccacggcgta cgcgccgctg ttccaggtga
     1261 tgttcgcctg gcagaacttc caccggaacg acttcgccct gcccggcctc gacgtgcggt
     1321 tcgagcggat ccgcaacgag agcgccaagt tcgacctgtt cttcaacatg gccgacatcc
     1381 cgggccacgg cgtcgtcggc cacctggagt acgccaccga cctgttcgac cccgcgagcg
     1441 cccaggggat caccgaccgg ttcatccgcg tcgtcggcct cctcgcggcc gacccggcgc
     1501 agcgcgtcgg cgccgtcgag ctggtcgagc ccgccgaacg ggacctggta ctgcgcgact
     1561 tcaacgacac cgcgcggccg acgcccgtgc tcaccgtgcc cggcctgttc gaggagcagg
     1621 cggcgcgcac tccggaggcg gtcgccgtcg tcgacggtga ctcgtcgtgg acgtaccgcg
     1681 aactggacgc gcgtgccgag ctgttggcgt gtgagctggt ccggcgcggg gtgggtccgg
     1741 aggcggtcgt gggtctggcg ctgccgcgtt cggcggacct ggtcgtgggc ttgctggggg
     1801 tgctcaaggc gggtgccgcg tatctgccga tcgacccgag gtaccccagc tcccgcttgg
     1861 accacatcct gtccgacgcg cggccgaggc tgctgctcac ggacgcggac accgtcgggg
     1921 tcctgccgga cagcggcatt ccgcggttgt tcgtcggtga cctcgacctg gagcctgaga
     1981 tgggcgacgt caaggtccgt gacctggacc gggtggtgcc gttgcggccg gacaatgtgg
     2041 cgtacgtgat gtacacctcg ggctcgaccg gcaccccgaa gggcgtcatg gtcacgcaca
     2101 ccaacgtggt gaacggcgtg acgcgcctcg ccgcgtccgt gggtatcgac tccgccacgc
     2161 ggatgctggc cgcgacgtcg gtcaacttcg acgtgtcggt cttcgagacc ttcgcgaccc
     2221 tgtcccaggg cggcaccgtc gaggtggccc gggacgtgct ggtcatcggg gaggggggcg
     2281 gctggacggg cggtgtcgtg tccactgttc cgtcggtgtt cgccgagctc cttgaccagg
     2341 tcgacggtga actcgttgtg gactccgtgg tgttcgcggg cgaggtcctg cccgcggcgc
     2401 tcgtggaccg ggtgcgcgag gccattccgg gtgtccgtgt cgtcaacgcc tacggccaga
     2461 cggagtcgtt ctacgcgacg acgtgggcgc tgcccgccga ccaggagtgg ggcggctcgg
     2521 gcagcgtccc catcggcgct ccgctcggca acatgcgggc ctatgtgctc ggttcgggtc
     2581 tcgcgcccgt gccggtgggt gtcgtgggtg agctgtacat cgcgggcaac gtggcgcgcg
     2641 gctacttcgg gcgcgccgac ctgaccgccg accgcttcgt cgccgacccc tacggcccgg
     2701 cgggttcgcg catgtaccgc accggcgacc tcgcccgctg gacccccgag ggccagctcg
     2761 actacgtcgg ccgcggtgac gcgcaggtca aggtgcgcgg catccgcatc gagcccggcg
     2821 aggtcgaggc cgcgctcgcc gcgcacccgg gtgtcgccca ggccgtcgtg gccgtcaagg
     2881 acggccgcgg cggcaagcag ctcgtcggct atgtggtccc ggccggtgag caggtcgagg
     2941 acgtcaacgc cgacctcgac ctgaccgccg gtgtcccggt ggaggaactg cgcaggttcg
     3001 cctccggccg cctgcccgag ttcatggtgc ccgcggtgtt cgtggtcctc gaccgcctgc
     3061 cgctggcccc caacggcaag ctggaccgcg aggccctgcc cgagccggag ttcacggcgg
     3121 gggagtaccg ggcgccgcgc accgccgagg agaaggtcct cgccggggtg tacgcggagg
     3181 tcctcggtct cggccgggtc ggtgtcgacg acgacttctt cgccgtcggc ggcgactcca
     3241 tccgctccat ccaggtggtg tcccgcgcca aggcacaggg cgtcgagacc acccctcggc
     3301 agatcttcga gtgccgcacg gtggccgagc tcgccgtcgc ggccgtcgag aaccggctcg
     3361 cgggcgccgg tgcggtcctg gaggagcttg cgggcggcgg cgtcggctgg atgccgctgc
     3421 ttcccgtggc ccgctacctg acgtccgaac tcggtgggaa caccgaccgg ttctccatgt
     3481 cgacggtcct cgacctgccg cagggcatcg acgaggcggg cctcttcgcg acgctgagcg
     3541 ccgtcgtcga ccaccacgac gtgctgcgtt cgcgcttccg cgccgagggc gagggcggcc
     3601 ttgaggtcac cgcgcccggc accgtcgacg tggcgccgct ggtgcaccgc gtggagtgcg
     3661 acggcgactg ggactcggct gcctggcggc ggctcgcgac cgccgaactc gacgccgcca
     3721 ccgggcggtt gaacccgacg gccggggtga tggcccagtt cgtgtggtgc gacaccgcgg
     3781 gtgccgaccc ggccggacgc ctcatcgtcg tcctgcacca cctggtcgtg gacggcgtgt
     3841 cctggcgcat cctggtgccg gacctggccg cggcctggga gggggtcaag gcgggcagga
     3901 cgccggagct cgctccggtc ggcacctccc tgcgccgctg gtcccacgcc ctcaaggacg
     3961 aggcgaaccg cgagtcccgc accgccgaac tcccgctgtg ggagggcatg ctggagggtg
     4021 ccgacccggt catcggctcg cgtccgctcg acccggcagt ggacgtcacc gccacggtgg
     4081 agaccgtgtc cgtgcagctg ccggtggcgg tgacggagtc cctcctgacg accgtcccgg
     4141 ccgcgttcca cggcggtgtc gacgacggcc tgctcgccgc cctcgccctc gcggtctcgc
     4201 gctggcgggg cgagcgtggc gtgccggagt cctcggcgtc ctcgacgctg atccggctgg
     4261 agggtcacgg gcgtgcggag cacgtggctc cgggcgcgga cgtctcgcgc accctcggct
     4321 ggttcacgag catgttcccg gtacgtctgg acgtcgccgg gcacgacgtg gccgaggcct
     4381 tcgccggtgg cagggccgcg ggcggcgtgg tcaaggcggt caaggagcag ctcctgtccg
     4441 tgcccgacaa gggcatcggc ttcggcctcc tgcgctacct gaacccggag acgtcccgcg
     4501 ccctcgcggg ccgcccgacc ggccagatcg cgttcaacta cctcggccgg ttctccgccg
     4561 acgacatgcc cgaggcactg cgcggcctcg gctggaccac cgcgcccgac accgacgcgc
     4621 tcatcgccga cctcgacgcg gagatgcccg ccctcgcgac ggtggacttc accgcgtacg
     4681 tcaccgacag cgcccaggga ccggagctca ccgcgagcgt cggcttcccc accggtgtgc
     4741 tgacccgcga cgaggtgcgg cgcctggcgg acctgtggtg cgcggccctg gacggcctca
     4801 cccggcacgc cgccgagccg gacgcgggcg gcctgacgcc gtccgacgtg ccgctcgtca
     4861 ccgtcgagca gtccgacatc gaggcctggg aggagaagta cccgggcgtc tcggacgtct
     4921 ggccgctcac cacgatgcag tcgggcctgc tgttccacag cttgctcggc gcccgtgacg
     4981 ccgagggccc ggccgacgcc cgcgacgcgt accacatcca gctcgtgatg cacctgtccg
     5041 gacagatcga cccggcccgc gtccgcaagg ccggtcaggc gctgctcgac cggtacgcga
     5101 acctgcgggc cgcgttcgtg cccgactcgg cgggcgagct ggtccagctc atcgtggacg
     5161 gcgccgaact cccctggagc caggccgact tcagcgcact gcccgagggc gagcgcgcgg
     5221 aggcattgga gaggctgctc gccgaggacc aggtcacccc cttcgacccg gccgccgcac
     5281 ccctgctgcg gatgtgcctg gtcacgatgg gcgacaacct ctccgagctg gtcttcagcg
     5341 cccaccacgt gctgtacgac ggctggtcct tcccgatgct cgtccaggac ctgcttcgtc
     5401 tgtacggctc acacggcgac ccggccgaac tgccgcgcgt gcgcggctac cgggagttcc
     5461 tggcctggct gtcgcagcag gaccggggcg aggccgcccg ggcctgggcg cgggagctgg
     5521 acggggtggc ggagccgacg atgctggctc cgggcgcctc ggcggaacag ggcggcctgg
     5581 acatggtcga ggtgccgctg cccacggagg acgccagggc cctgtcccgg cgcgccgcgg
     5641 agctgggcat caccctcaac accctggtgc agggcgcctg ggcgctcgcc ctgggccagt
     5701 tgacgggacg tcaggacgtg acgttcggcg ccacggtgtc cggccgtccg ccgtcggtga
     5761 ccggcgtcga caccatggtc ggcctgttca tcaacaccct gcccgtgcgg gtggcggccg
     5821 agccgggcca gaccctggcc cagctcctca ccggcctcca ggaccgtcag gccgcgctcc
     5881 tggaccacca ccactacggc ctgtcggaca tccagcgggc caccggactc ggcacgctct
     5941 tcgacaccct cgtggtgttc gagtccttcc cggtcgacca cgcgggcatg agcgacgcca
     6001 acgccgcggc gggcatcgcg gtgacgggcc tgcgcgcgtc cagcggtacg cactacccgc
     6061 tgatcgtcgg cgccgacgcc tcgccgcacc tgcgcctcgg cctgcagtac caggacacca
     6121 ggtacgacaa ggacacggtg aagggcatcg cgggccgcct cggccgggtg ctccagcaga
     6181 tcgcggccga cccggagacg cccgtcaagg acgtcgacgt gctggcgccg gaggagcggc
     6241 agcggctgct cgtcgcgttc aacgacaccg cgcggccgac gcccgcgctc accgtgcccg
     6301 gcctgttcga ggagcaggcg gcgcgtactc cggaggcggt cgccgtcgtc gacggtgact
     6361 cgtcgtggac gtaccgcgaa ctggacgcgc gtgccgagct gttggcgcgt gagctggtcc
     6421 ggcgcggggt gggtccggag gcggtcgtgg gtctggcgct gccgcgttcg gcggacctgg
     6481 tcgtgggctt gctgggggtg ctcaaggcgg gtgccgcgta tctgccgatc gacccgaggt
     6541 accccagctc ccgcttggac cacatcctgt ccgacgcggc gccgaagctc ctgctcacgg
     6601 acgcggacac cgtcggcgtg ctgcccgaga cggacatccc gcgcctgttc ctcggcgccg
     6661 tggacctcga accggcggcc accgacgccc cgttgacgga tgccgaccgc agggccgcgc
     6721 tcaagccgga ccacatcgcg tacgtgatgt acacctcggg ctcgaccggc accccgaagg
     6781 gcgtggcggt cacgcacgcc aacgtggtca acggcgtcac gcgcctggtc gagcgggtcg
     6841 gcggcgcggg ttcacggatg ctcgcgggca cctcggtcaa cttcgacgtg tcggtcttcg
     6901 agaccttcac gaccctgtcg accggcggca ccctcgaagt cgtccgggac gtcctggtca
     6961 tcggcgagcg gggcggctgg tcgggtggcg tcgtctccac cgtcccgtcg gtcttcgccg
     7021 aaatcctcga ccaggtcgac ggcgaactcg tcgtggactc cgtggtgttc gcgggtgagg
     7081 cgctgcccgc ggcgctcgtg gaccgcgtgc gcgaggccat tccgggtgtc cgtgtcgtca
     7141 acgcctacgg ccagacggag tcgttctacg cgacgacctt cacgctgccc gccgaccagg
     7201 agtggaccgg caccggcagc gcccccatcg gcaccccgct cggcaacatg cgcgcctaca
     7261 tcctcggccc cactctccaa ccggcacccg agagtgtcgt gggtgagctg tacatcgcgg
     7321 gtaacgtggc gcgcggctac ttcgggcgcg ccgacttgac cgccgaccgc tttgtcgccg
     7381 acccctacgg cccggcgggc ggccgtatgt accgcaccgg tgacctcgcg cggtggaacg
     7441 cggacgggca gttggagtac gtcggtcgcg gtgacgcgca gttcaaggtg cggggcttcc
     7501 gcatcgagcc cggcgaggtc gaggccgcgc tcgccgcgca cccggacgtg gcgcagggcg
     7561 tggtcgtggc caagggcacc ggcaccaccg acaagcgctt ggtggcgtat gtcgtcccgg
     7621 ccgggaacgt cgaggacatc gacgtcaccg cgctgcggga gcacgtgggc ggaaagctgc
     7681 ccgagttcat ggtcccgtcg gccttcgtcg tcctggagcg ccttccgctg
//
