LOCUS       NZ_BMVR01000044         8874 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence44, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000044
VERSION     NZ_BMVR01000044.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 8874)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 8874
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000044.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..8874
                     /culture_collection="JCM:4753"
                     /db_xref="taxon:68200"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces flavofungini"
                     /strain="JCM 4753"
                     /submitter_seqid="sequence44"
                     /type_material="type strain of Streptomyces flavofungini"
     gene            <1..>8874
                     /locus_tag="IE274_RS38915"
     region          1..8874
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..8874
                     /SMILES="NC(C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8874
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[4:>8874](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5..>8874
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             5..>8874
                     /NRPS_PKS="Domain: Epimerization (48-361). E-value:
                     7.5e-123. Score: 402.8. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (377-537). E-value: 2.8e-38.
                     Score: 123.1. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_TIGR01720.1"
                     /NRPS_PKS="Domain: Condensation_DCL (547-841). E-value:
                     1.4e-110. Score: 361.1. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1006-1385). E-value:
                     6.2e-109. Score: 356.2. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_AMP-binding.1"
                     /NRPS_PKS="Domain: nMT (1472-1690). E-value: 1.5e-92.
                     Score: 301.9. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_nMT.1"
                     /NRPS_PKS="Domain: PCP (1887-1954). E-value: 1.9e-27.
                     Score: 87.2. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1970-2272). E-value:
                     1.9e-114. Score: 373.6. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (2438-2834). E-value:
                     3.5e-102. Score: 334.0. Matches aSDomain:
                     nrpspksdomains_IE274_RS38915_AMP-binding.2"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638469.1"
                     /locus_tag="IE274_RS38915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_190120681.1"
                     /sec_met_domain="PP-binding (E-value: 1.4e-20, bitscore:
                     59.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 7.7e-76, bitscore:
                     241.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-114, bitscore:
                     369.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSRARVLGVEVTPRQIFECRTVAELAQVAVADGSDAGVVLEEFE
                     GGGVGRLPVLPVSRYLRELGGGFGRFSMSAVLDLPVGIDAVGLAVTLGAVFDRHDILRS
                     RLVAGDEWSLEVAERGSVDVAGLVHRVECDGEWGAPGWRELAEAELDEATGRLDPEGGV
                     MGRFVWFDPGADVPGRLLVVLHHLVVDGVSWRILLPDFAAAWEQVRAGRVPELAPVGTS
                     VRRWTHALQDEAVSEDRIAELPLWRAMVDGPDPLLGHRPLDPTLDVSDTVDHLWVQLPA
                     RVTEALLTSVPTAFRGQVNDGLLAGLALAVAKWRQKRGISESSALIRLEGHGREQGVVP
                     GADLSRTVGWFTSMFPVRLDTTGIDLSDAFAGGPAAAGAIKAVKEQLLAIPDKGIGYGL
                     LRHLNPDTATVLRRYDTGQIAFNYLGRFSAADMPENLRGLGWTRAENTTDLVAAPDADM
                     PLMSTLEINALVSDTEQGPCLNARVGFPTGVLSREDVQELADLWCAALEGLARHVARPG
                     AGGLTPSDVPLVSVDQRKLEVWEKKYPGLADVWPLTALQSGLLFHALLADAAYDAYHMQ
                     LVFHLSGPVEPERMRAAGQAVLDRYPSLRTAFVSNTSGERVQLVVDDVQLPWHHTDLSD
                     HGDDRDAALERILADDRATHFDLTAPPLLRMTLVTMGPDRAELVFTAHHVLFDGWSVPL
                     LMEDLLRLYGSAGDLAALPKVRGYRDFLTWLAQQDHDAAARAWAEELDGLDEPTLLAPG
                     AESADSEDIGQVDVPLSPETARELTRYAAEAGVTLNTLVQGVWAVVVGELTGREDVVFG
                     ATVSGRPPAVPDIDTMVGLFINTLPVRVTCSPRDTFRELLTRLQDRQAVLLDHHHHGLA
                     RIQQDTGLSTLFDTVVVFESFPIDHAGLGDANAEAGVAITGLTPFSGTHYPLTVTADAD
                     PQLRIALQYQHHLFDHATVEAIATRCLRVLLQVVENPSIRVAQLDVLESAERTKVVSEW
                     NDTAHTTATVGSTLAAAFEAQVERGPERTALVFEGETLSYADFNTRANRLAHWLIERGA
                     GPERLVAIRMPRSFDLLTAIYGVLKTGAAYLPIETDLPAERVEHMLADSTPLLVLDELP
                     DLSGHPESNPGVDVHEDHAAYVIYTSGSTGKPKGVVVSHRSIMNRLAWGHGHYGMDESD
                     RMLLKTSVGFDVSVPELFWPLQVGAALVIVRPDGQKDPEYLARLIREQRVTDADFAPSM
                     LAAFLSEPTADQCTSLRRVEAAGEALPLELTERFAQVLPGTRLHNLYGPTEAAVEVTAW
                     ECREEPGATGVPIGAPVWNTQVYVLDSALRPVPPGVPGELYLAGVQLARGYLNRPGLTA
                     ERFVASPFTPGARMYRTGDLVKWRPDGVIDYLGRVDFQVKVRGFRIEPGDIEAALAAHP
                     GVDQAVVITREDRPGDQRIVGYVVPAPTGSATAREAEQVDEWQQVYDEAYAGSGKTAWG
                     EDFTGWNSSYTGEPIPLVEMRAWRDAAVEQILGRAPQRVLELGVGSGLLLSQIVPDVAE
                     YWGTDFSAPVIAQLQDQVERAGFTERVRLRVQPADDASGLPQEHFDTVVINSVAQYFPD
                     ADYLDRVLSQALGLLAPGGRIVIGDVRHAGSLNLLKTAIHHAQRPEASASVVRAAVARA
                     VLVEKELVLDPEWFTRWADEHGAAGVEVLLKPGRAHNELTRHRYEVVLHKAPVDLVPLT
                     AIPALAWGRRVDDFTGLDEVVQEHGTTPVRITRIPNARLAGEVATATALAAVDSPVAGL
                     PPLDPHDLRDWADRRGLGLLLTLTAGVPECFDAVVFPAGTEAGRTYSGGFTPTGRPERM
                     LANDPAGAREIGVLVAGLRDHAQERLPEYMVPAAVVAIAEVPLTPNGKLDRQALPVPDY
                     AGVATGRPPRTPQEEVLCALFAEVLGIDRVGIDDNFFALGGHSLLATRLISRIRAELGA
                     EVPIRAVFDCPTVVELVERIAPGARVRSPLRRAAQRPEQPPLSFAQRRLWFIDRFEGPS
                     ATYNIPFVLRLTGALDVAALENAVRDVVSRHEILRTLIAESGDGVPYQRVLPAAPAPVD
                     LHVVESAPEAVADAVAAVAARPFDLATEIPLRVTVVRGAADEHVLVLVVHHIAGDGESM
                     GPLARDLGTAYAARRHGERPDWPEPPVQYVDYTLWQRELLADESDPDGVLATQLRYWRD
                     ELAGVPQPLQLPTDRPRPPVASRRGDLVAFELDPDLVTAVEELARAQGATVSMVLQSAV
                     AVLLHHLGGGEDITVGSPIAGRTDAALAELVGFFVNTWVLRADLSGNPSFQGLLGQVRE
                     KALAAYENQDAPFERLVELLKPDRSTAYHPLFQVMFAWQNMAREDFALDGLRVDLEHPS
                     TDTAKFDLFFNMADIPGLGVVGHLEYATDLFDRATVEALAARFARVVQQLVTSPGRPIG
                     AIVDVLDAAERELVIHRFNDTAAPTPDVTVPALFERQAAATPDAVAVVSGERTLTYREL
                     DTRANHVARELAARGVGPETVVGLALPRSADLVVALLGVLKAGGAYLPVDPKYPSTRLD
                     FILSDSRPRLFLTDAETVGVLPDDGTPRLFVGDAEKAGADAGNAGTDAGQARPRPHNAA
                     YVMYTSGSTGTPKGVTITHHNVVNGVLRLAERVGIEPGTRVLAGTSVNFDVSVFEVFTT
                     LTHGGCVEVVRDVLELADREDWQGGVISTVPSVFAELVDDIVGTVAVDAVVFAGEALPA
                     SLAERVRQAFPGVRVVNAYGQTESFYATTFQLSSGAEWDGSGSAPIGSPLGNMRAYVLG
                     PGLLPVPPGVVGELYVAGSVARGYHGRAGLTAERFVADPFGGPGARMYRTGDLARWTAE
                     GQLEYVGRDDAQVKVRGFRIEPGEVEAALTAHPGVSQAVVVTRTGQGTKQLVGYVVPTG
                     ADDATGDTEGLSDDAIDLTSGVDTAELRRFVAGRLPEFMVPSVLVMLDRLPLAPNGKLD
                     RSGLPEPEFGGGAYRAPGSVV"
     aSDomain        151..1089
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_Epimerization.1"
                     /evalue="7.50E-123"
                     /label="IE274_RS38915_Epimerization.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="361"
                     /protein_start="48"
                     /score="402.8"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDG"
                     /tool="antismash"
                     /translation="VGRLPVLPVSRYLRELGGGFGRFSMSAVLDLPVGIDAVGLAVTLG
                     AVFDRHDILRSRLVAGDEWSLEVAERGSVDVAGLVHRVECDGEWGAPGWRELAEAELDE
                     ATGRLDPEGGVMGRFVWFDPGADVPGRLLVVLHHLVVDGVSWRILLPDFAAAWEQVRAG
                     RVPELAPVGTSVRRWTHALQDEAVSEDRIAELPLWRAMVDGPDPLLGHRPLDPTLDVSD
                     TVDHLWVQLPARVTEALLTSVPTAFRGQVNDGLLAGLALAVAKWRQKRGISESSALIRL
                     EGHGREQGVVPGADLSRTVGWFTSMFPVRLDT"
     aSModule        151..1617
                     /domains="nrpspksdomains_IE274_RS38915_Epimerization.1"
                     /domains="nrpspksdomains_IE274_RS38915_TIGR01720.1"
                     /incomplete
                     /locus_tags="IE274_RS38915"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       253..327
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0001"
                     /evalue="1.20E-03"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS38915"
                     /protein_end="107"
                     /protein_start="82"
                     /score="11.1"
                     /tool="antismash"
                     /translation="IDAVGLAVTLGAVFDRHDILRSRLV"
     CDS_motif       544..609
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0002"
                     /evalue="1.10E-10"
                     /label="NRPS-E2"
                     /locus_tag="IE274_RS38915"
                     /protein_end="201"
                     /protein_start="179"
                     /score="33.7"
                     /tool="antismash"
                     /translation="LLVVLHHLVVDGVSWRILLPDF"
     CDS_motif       1033..1083
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0003"
                     /evalue="3.30E-09"
                     /label="NRPS-E5"
                     /locus_tag="IE274_RS38915"
                     /protein_end="359"
                     /protein_start="342"
                     /score="28.7"
                     /tool="antismash"
                     /translation="DLSRTVGWFTSMFPVRL"
     aSDomain        1138..1617
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_TIGR01720.1"
                     /evalue="2.80E-38"
                     /label="IE274_RS38915_TIGR01720.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="537"
                     /protein_start="377"
                     /score="123.1"
                     /tool="antismash"
                     /translation="GAIKAVKEQLLAIPDKGIGYGLLRHLNPDTATVLRRYDTGQIAFN
                     YLGRFSAADMPENLRGLGWTRAENTTDLVAAPDADMPLMSTLEINALVSDTEQGPCLNA
                     RVGFPTGVLSREDVQELADLWCAALEGLARHVARPGAGGLTPSDVPLVSVDQRKLE"
     CDS_motif       1153..1215
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0004"
                     /evalue="1.40E-10"
                     /label="NRPS-E6"
                     /locus_tag="IE274_RS38915"
                     /protein_end="403"
                     /protein_start="382"
                     /score="33.2"
                     /tool="antismash"
                     /translation="VKEQLLAIPDKGIGYGLLRHL"
     CDS_motif       1633..1701
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0005"
                     /evalue="3.80E+01"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IE274_RS38915"
                     /protein_end="565"
                     /protein_start="542"
                     /score="-3.4"
                     /tool="antismash"
                     /translation="YPGLADVWPLTALQSGLLFHALL"
     aSDomain        1648..2529
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.40E-110"
                     /label="IE274_RS38915_Condensation_DCL.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="841"
                     /protein_start="547"
                     /score="361.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVLFDG"
                     /tool="antismash"
                     /translation="DVWPLTALQSGLLFHALLADAAYDAYHMQLVFHLSGPVEPERMRA
                     AGQAVLDRYPSLRTAFVSNTSGERVQLVVDDVQLPWHHTDLSDHGDDRDAALERILADD
                     RATHFDLTAPPLLRMTLVTMGPDRAELVFTAHHVLFDGWSVPLLMEDLLRLYGSAGDLA
                     ALPKVRGYRDFLTWLAQQDHDAAARAWAEELDGLDEPTLLAPGAESADSEDIGQVDVPL
                     SPETARELTRYAAEAGVTLNTLVQGVWAVVVGELTGREDVVFGATVSGRPPAVPDIDTM
                     VGLFINTLPVRVT"
     aSModule        1648..5868
                     /complete
                     /domains="nrpspksdomains_IE274_RS38915_Condensation_DCL.1"
                     /domains="nrpspksdomains_IE274_RS38915_AMP-binding.1"
                     /domains="nrpspksdomains_IE274_RS38915_nMT.1"
                     /domains="nrpspksdomains_IE274_RS38915_PCP.1"
                     /locus_tags="IE274_RS38915"
                     /monomer_pairings="Ala -> NMe-Ala"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1717..1833
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0006"
                     /evalue="2.50E-16"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS38915"
                     /protein_end="609"
                     /protein_start="570"
                     /score="51.9"
                     /tool="antismash"
                     /translation="DAYHMQLVFHLSGPVEPERMRAAGQAVLDRYPSLRTAFV"
     CDS_motif       2053..2115
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0007"
                     /evalue="2.70E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="IE274_RS38915"
                     /protein_end="703"
                     /protein_start="682"
                     /score="29.5"
                     /tool="antismash"
                     /translation="HHVLFDGWSVPLLMEDLLRLY"
     CDS_motif       2158..2181
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0008"
                     /evalue="3.90E+01"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE274_RS38915"
                     /protein_end="725"
                     /protein_start="717"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="YRDFLTWL"
     CDS_motif       2428..2523
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0009"
                     /evalue="1.30E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="IE274_RS38915"
                     /protein_end="839"
                     /protein_start="807"
                     /score="62.6"
                     /tool="antismash"
                     /translation="DVVFGATVSGRPPAVPDIDTMVGLFINTLPVR"
     CDS_motif       2572..2685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0010"
                     /evalue="1.10E-13"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IE274_RS38915"
                     /protein_end="893"
                     /protein_start="855"
                     /score="43.5"
                     /tool="antismash"
                     /translation="QDRQAVLLDHHHHGLARIQQDTGLSTLFDTVVVFESFP"
     CDS_motif       2824..2859
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0011"
                     /evalue="3.20E+01"
                     /label="C3_dual_135-156"
                     /locus_tag="IE274_RS38915"
                     /protein_end="951"
                     /protein_start="939"
                     /score="-1.9"
                     /tool="antismash"
                     /translation="QHHLFDHATVEA"
     aSDomain        3025..4161
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_AMP-binding.1"
                     /evalue="6.20E-109"
                     /label="IE274_RS38915_AMP-binding.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1385"
                     /protein_start="1006"
                     /score="356.2"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="FEAQVERGPERTALVFEGETLSYADFNTRANRLAHWLIERGAGPE
                     RLVAIRMPRSFDLLTAIYGVLKTGAAYLPIETDLPAERVEHMLADSTPLLVLDELPDLS
                     GHPESNPGVDVHEDHAAYVIYTSGSTGKPKGVVVSHRSIMNRLAWGHGHYGMDESDRML
                     LKTSVGFDVSVPELFWPLQVGAALVIVRPDGQKDPEYLARLIREQRVTDADFAPSMLAA
                     FLSEPTADQCTSLRRVEAAGEALPLELTERFAQVLPGTRLHNLYGPTEAAVEVTAWECR
                     EEPGATGVPIGAPVWNTQVYVLDSALRPVPPGVPGELYLAGVQLARGYLNRPGLTAERF
                     VASPFTPGARMYRTGDLVKWRPDGVIDYLGRVDFQVKVR"
     CDS_motif       3214..3249
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0012"
                     /evalue="3.00E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1081"
                     /protein_start="1069"
                     /score="11.2"
                     /tool="antismash"
                     /translation="GVLKTGAAYLPI"
     CDS_motif       3385..3444
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0013"
                     /evalue="8.50E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1146"
                     /protein_start="1126"
                     /score="33.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVVVSH"
     CDS_motif       3955..4044
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0014"
                     /evalue="1.10E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1346"
                     /protein_start="1316"
                     /score="56.0"
                     /tool="antismash"
                     /translation="PPGVPGELYLAGVQLARGYLNRPGLTAERF"
     CDS_motif       4126..4191
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0015"
                     /evalue="1.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1395"
                     /protein_start="1373"
                     /score="36.0"
                     /tool="antismash"
                     /translation="YLGRVDFQVKVRGFRIEPGDIE"
     aSDomain        4423..5076
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_nMT.1"
                     /domain_subtypes="nMT"
                     /evalue="1.50E-92"
                     /label="IE274_RS38915_nMT.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1690"
                     /protein_start="1472"
                     /score="301.9"
                     /tool="antismash"
                     /translation="GEPIPLVEMRAWRDAAVEQILGRAPQRVLELGVGSGLLLSQIVPD
                     VAEYWGTDFSAPVIAQLQDQVERAGFTERVRLRVQPADDASGLPQEHFDTVVINSVAQY
                     FPDADYLDRVLSQALGLLAPGGRIVIGDVRHAGSLNLLKTAIHHAQRPEASASVVRAAV
                     ARAVLVEKELVLDPEWFTRWADEHGAAGVEVLLKPGRAHNELTRHRYEVVLHKAP"
     aSDomain        5668..5868
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_PCP.1"
                     /evalue="1.90E-27"
                     /label="IE274_RS38915_PCP.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="1954"
                     /protein_start="1887"
                     /score="87.2"
                     /tool="antismash"
                     /translation="EEVLCALFAEVLGIDRVGIDDNFFALGGHSLLATRLISRIRAELG
                     AEVPIRAVFDCPTVVELVERIA"
     aSDomain        5917..6822
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.90E-114"
                     /label="IE274_RS38915_Condensation_LCL.1"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2272"
                     /protein_start="1970"
                     /score="373.6"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAGDG"
                     /tool="antismash"
                     /translation="EQPPLSFAQRRLWFIDRFEGPSATYNIPFVLRLTGALDVAALENA
                     VRDVVSRHEILRTLIAESGDGVPYQRVLPAAPAPVDLHVVESAPEAVADAVAAVAARPF
                     DLATEIPLRVTVVRGAADEHVLVLVVHHIAGDGESMGPLARDLGTAYAARRHGERPDWP
                     EPPVQYVDYTLWQRELLADESDPDGVLATQLRYWRDELAGVPQPLQLPTDRPRPPVASR
                     RGDLVAFELDPDLVTAVEELARAQGATVSMVLQSAVAVLLHHLGGGEDITVGSPIAGRT
                     DAALAELVGFFVNTWVLRADL"
     aSModule        5917..8508
                     /domains="nrpspksdomains_IE274_RS38915_Condensation_LCL.1"
                     /domains="nrpspksdomains_IE274_RS38915_AMP-binding.2"
                     /incomplete
                     /locus_tags="IE274_RS38915"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       5983..6093
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0016"
                     /evalue="3.00E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2029"
                     /protein_start="1992"
                     /score="58.2"
                     /tool="antismash"
                     /translation="ATYNIPFVLRLTGALDVAALENAVRDVVSRHEILRTL"
     CDS_motif       6304..6369
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0017"
                     /evalue="3.00E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2121"
                     /protein_start="2099"
                     /score="26.2"
                     /tool="antismash"
                     /translation="VHHIAGDGESMGPLARDLGTAY"
     CDS_motif       6418..6456
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0018"
                     /evalue="2.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2150"
                     /protein_start="2137"
                     /score="13.7"
                     /tool="antismash"
                     /translation="QYVDYTLWQRELL"
     CDS_motif       6724..6813
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0019"
                     /evalue="3.30E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2269"
                     /protein_start="2239"
                     /score="48.4"
                     /tool="antismash"
                     /translation="DITVGSPIAGRTDAALAELVGFFVNTWVLR"
     CDS_motif       6862..6981
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0020"
                     /evalue="2.20E-22"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2325"
                     /protein_start="2285"
                     /score="71.5"
                     /tool="antismash"
                     /translation="REKALAAYENQDAPFERLVELLKPDRSTAYHPLFQVMFAW"
     aSDomain        7321..8508
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS38915_AMP-binding.2"
                     /evalue="3.50E-102"
                     /label="IE274_RS38915_AMP-binding.2"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2834"
                     /protein_start="2438"
                     /score="334.0"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FERQAAATPDAVAVVSGERTLTYRELDTRANHVARELAARGVGPE
                     TVVGLALPRSADLVVALLGVLKAGGAYLPVDPKYPSTRLDFILSDSRPRLFLTDAETVG
                     VLPDDGTPRLFVGDAEKAGADAGNAGTDAGQARPRPHNAAYVMYTSGSTGTPKGVTITH
                     HNVVNGVLRLAERVGIEPGTRVLAGTSVNFDVSVFEVFTTLTHGGCVEVVRDVLELADR
                     EDWQGGVISTVPSVFAELVDDIVGTVAVDAVVFAGEALPASLAERVRQAFPGVRVVNAY
                     GQTESFYATTFQLSSGAEWDGSGSAPIGSPLGNMRAYVLGPGLLPVPPGVVGELYVAGS
                     VARGYHGRAGLTAERFVADPFGGPGARMYRTGDLARWTAEGQLEYVGRDDAQVKVR"
     CDS_motif       7507..7548
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0021"
                     /evalue="8.70E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2514"
                     /protein_start="2500"
                     /score="15.8"
                     /tool="antismash"
                     /translation="LGVLKAGGAYLPVD"
     CDS_motif       7750..7809
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0022"
                     /evalue="1.80E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2601"
                     /protein_start="2581"
                     /score="29.6"
                     /tool="antismash"
                     /translation="AYVMYTSGSTGTPKGVTITH"
     CDS_motif       8302..8388
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0023"
                     /evalue="1.00E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2794"
                     /protein_start="2765"
                     /score="43.4"
                     /tool="antismash"
                     /translation="PPGVVGELYVAGSVARGYHGRAGLTAERF"
     CDS_motif       8473..8538
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0024"
                     /evalue="1.30E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2844"
                     /protein_start="2822"
                     /score="33.3"
                     /tool="antismash"
                     /translation="YVGRDDAQVKVRGFRIEPGEVE"
     CDS_motif       8575..8628
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS38915_0025"
                     /evalue="3.40E-01"
                     /label="C5_LCL_267-296"
                     /locus_tag="IE274_RS38915"
                     /protein_end="2874"
                     /protein_start="2856"
                     /score="3.6"
                     /tool="antismash"
                     /translation="VVVTRTGQGTKQLVGYVV"
ORIGIN
        1 aggtggtgtc gcgggcgcgg gtgctgggtg tggaggtgac gccgcggcag atctttgagt
       61 gccggacggt ggccgagctg gcgcaggtgg cggtggcgga tggctcggat gcgggtgtgg
      121 tgttggagga gttcgagggg ggtggtgtgg gtcggctgcc ggtgttgccg gtgagtcggt
      181 atctgcggga gttgggtggt gggttcggtc ggttctcgat gtcggcggtg ctggatttgc
      241 cggtggggat cgatgcggtg ggcctggcgg tgacgttggg tgcggtgttc gaccggcatg
      301 acattcttcg ctcgcggctg gtggctggtg atgagtggag tctggaggtt gctgagcggg
      361 gttcggtgga cgtggcgggc ctggtccatc gggtggagtg tgatggtgag tggggtgcgc
      421 cgggctggcg ggagctggcg gaggcggagc tggatgaggc caccgggcgg ttggatcccg
      481 agggtggggt gatgggccgg ttcgtgtggt tcgatccggg tgcggacgtt cctggtcggc
      541 tgctggtggt gttgcatcac ctggtggtgg acggggtgtc gtggcggatc ctgctgccgg
      601 acttcgccgc agcctgggag caggtgcgtg cgggtcgggt gccggagctc gcgccggtgg
      661 gtacgtcggt gcggcgctgg acgcacgccc ttcaggatga ggccgtcagc gaggaccgga
      721 tcgccgaact ccccctctgg cgtgccatgg tggacggccc ggaccccctc ctcggccacc
      781 gccccctgga cccgaccctc gacgtgtccg acaccgtcga ccatctctgg gtccaactgc
      841 cggcgcgggt gacggaggcg ctgctcacgt cggtgccgac ggcgttccgt ggccaggtga
      901 acgacggtct gctggccggg ctcgccctcg cggtggccaa gtggcggcag aagcgcggca
      961 tctcggagtc ctcggcgctg atccgcctcg aaggacacgg ccgtgagcag ggcgtcgtgc
     1021 cgggtgcgga tctgtcccgc acggtgggct ggttcaccag catgttcccc gtccgcctcg
     1081 acaccacggg aatcgacctc agtgacgcct tcgcgggcgg ccccgcagcc gcgggcgcga
     1141 tcaaggccgt caaggagcag ctcctcgcca tccccgacaa gggcatcggc tacggcctgc
     1201 tgcgccatct gaacccggac acggcgacgg tgctccggcg gtacgacacc gggcagatcg
     1261 ccttcaacta cctgggccgg ttctccgccg ccgacatgcc ggagaacctg cgcggcctcg
     1321 gctggacccg ggccgagaac accaccgacc tggtcgccgc gccggacgcg gacatgccgc
     1381 tgatgtcgac gctggagatc aacgcactgg tcagcgacac agagcagggc ccgtgcctga
     1441 acgcccgcgt gggcttcccc accggcgtgc tgtcccgtga ggacgtgcag gagctggccg
     1501 acctgtggtg cgcggcgctg gaaggcctcg cccggcacgt ggcgcggccg ggcgccggtg
     1561 gtctgacgcc gtcggacgtg ccgctggtgt cggtggacca gcgcaagctg gaggtctggg
     1621 agaagaagta ccccggcctg gccgacgtgt ggccgctgac cgcactgcag tccgggctgc
     1681 tcttccacgc cctgctggcg gacgctgcgt acgacgcgta ccacatgcag ttggtgttcc
     1741 acctctccgg accggtggag cccgagcgga tgcgggccgc gggacaggcc gtcctggacc
     1801 gctaccccag cctgcggacc gcgttcgtca gcaatacctc gggtgagcgc gtccagctcg
     1861 tcgtcgacga cgtccaactg ccctggcacc acaccgacct gagcgaccac ggcgacgacc
     1921 gtgacgcggc gctcgaacgg atcctcgccg acgaccgcgc cacgcacttc gacctgaccg
     1981 caccgccgct cctgcggatg accctggtga ccatgggccc ggaccgggcc gaactggtct
     2041 tcaccgccca ccacgtcctg ttcgacggct ggtccgtccc cctcctcatg gaggacctgc
     2101 tcaggctgta cggctccgcc ggggacctcg cggccctgcc gaaggtgcgc ggctaccggg
     2161 acttcctgac ctggctggcc cagcaggacc acgacgcggc cgcccgcgcc tgggccgagg
     2221 aactcgacgg gctcgacgaa cccaccctgc tcgcccccgg cgcggagtcc gccgactccg
     2281 aggacatcgg acaggtcgac gtacccctgt caccggagac cgcccgcgaa ctcacccggt
     2341 acgcggccga ggcgggcgtc accctgaaca ccctggtgca gggggtctgg gcggtcgtcg
     2401 tcggagagct gaccgggcgc gaggacgtgg tgttcggcgc gacggtgtcc ggccgcccgc
     2461 ccgccgtccc ggacatcgac accatggtcg gcctgttcat caacaccctt cccgtacgcg
     2521 tgacctgctc gccccgggac accttccggg agttgctgac gcggctccag gaccggcagg
     2581 ccgtcctgct cgaccaccac caccacggcc tcgcgcggat ccagcaggac accggcctga
     2641 gcaccctctt cgacaccgtc gtcgtcttcg agtccttccc gatcgaccac gcggggctcg
     2701 gcgacgccaa cgccgaggcg ggcgtggcga tcaccgggct caccccgttc agcggcaccc
     2761 actacccgct gaccgtgacg gccgacgccg acccgcagct gcgcatcgcg ctgcagtacc
     2821 agcaccacct cttcgaccac gccaccgtgg aagccatcgc cacccgctgc ctgcgggtgc
     2881 tgctccaggt cgtcgagaac ccgtcgatcc gcgtcgcgca gctcgacgtc ctggagtccg
     2941 ccgagcggac caaggtcgtg tccgagtgga acgacaccgc gcacaccacg gccaccgtcg
     3001 gcagcaccct cgccgcggcg ttcgaagccc aggtggagcg cggcccggag cgcaccgcgc
     3061 tcgtcttcga aggcgaaacg ctctcctacg ccgacttcaa cacgcgcgcc aaccggctcg
     3121 cgcactggct gatcgagcgg ggcgccggtc ccgagcggct cgtcgcgatc cggatgccgc
     3181 gctccttcga cctgctcacc gcgatctacg gcgtgctcaa gacaggagcc gcctatctgc
     3241 cgatcgagac cgatctgccc gccgagcggg tcgagcacat gctcgccgac agcacacccc
     3301 tcctcgtcct ggacgaactc ccggacctct ccggacaccc ggagtcgaac cccggcgtcg
     3361 acgtgcacga ggaccacgcc gcctacgtga tctacacctc ggggtcgacc gggaagccca
     3421 agggcgtggt cgtgtcccac cgttcgatca tgaaccggct cgcctggggc cacggccact
     3481 acggcatgga cgagagcgac cggatgctcc tgaagacatc cgtcggcttc gacgtgtcgg
     3541 tgcccgagct gttctggccg ctgcaggtcg gggcggcgct ggtgatcgta cggccggacg
     3601 gacagaagga ccccgagtac ctggccaggc tgatccggga acagcgggtc accgacgccg
     3661 acttcgcgcc gtccatgctg gcggcgttcc tctcggagcc gaccgcggac cagtgcacca
     3721 gcctgcgccg ggtggaggcc gcgggcgagg cgctccccct ggagctcacc gagcgcttcg
     3781 cgcaggtgct ccccggcacc cggctgcaca atctctacgg ccccaccgag gccgcggtcg
     3841 aggtcacggc ctgggagtgc cgcgaggagc ccggcgccac cggcgtgccg atcggcgcac
     3901 ccgtgtggaa cacccaggtc tacgtcctcg actccgcgct gcggccggtc cccccggggg
     3961 tgccgggaga gctctacctc gcgggcgtcc agctcgcccg cggctacctg aaccgtccgg
     4021 gcctgaccgc cgaacgcttc gtggccagcc cgttcacccc cggtgcgcgc atgtaccgca
     4081 ccggtgacct ggtcaagtgg cggcccgacg gcgtgatcga ctacctcggc cgggtcgact
     4141 tccaggtcaa ggtgcgcgga ttccgcatcg agcccggcga catcgaagcg gccctcgccg
     4201 cgcaccccgg cgtggaccag gccgtggtga tcacccgcga ggaccggccc ggcgaccagc
     4261 gcatcgtggg ctacgtggtg cccgccccca ccggctcggc caccgcccgg gaggcggagc
     4321 aggtcgacga gtggcagcag gtgtacgacg aggcgtacgc cggttccggg aagaccgcct
     4381 ggggcgagga cttcaccggc tggaactcca gctacaccgg agagccgatc ccgctggtgg
     4441 agatgcgggc ctggcgggac gccgccgtcg agcagatcct cggcagggcg ccgcagcgcg
     4501 tcctcgaact gggcgtcggc tcgggtctgc tgctctccca gatcgtgccc gacgtcgcgg
     4561 agtactgggg cacggacttc tcggcccccg tcatcgcaca gctgcaggac caggtcgaga
     4621 gggccgggtt caccgagcgg gtccggctgc gggtgcagcc cgctgacgac gcgtcgggcc
     4681 tgccccagga gcacttcgac accgtcgtca tcaactcggt ggcgcagtac ttccccgacg
     4741 ccgactatct ggaccgggtg ctgagccagg ccctcggcct gctggccccc ggcggccgca
     4801 tcgtgatcgg tgacgtgcgc cacgcgggct cgctgaacct gttgaagacg gcgatccacc
     4861 acgcccagcg cccggaggcc tcggcgtccg tggtccgcgc cgccgtcgcc cgcgccgtcc
     4921 tggtcgagaa ggaactggtc ctcgacccgg agtggttcac acgctgggcc gacgaacacg
     4981 gcgccgccgg ggtggaggtg ctcctgaagc ccggccgcgc ccacaacgaa ctgacccggc
     5041 accgctacga agtggtgctg cacaaggcac ccgtggacct cgtccccctg accgcgatcc
     5101 cggcgctcgc ctggggccgc agggtggacg acttcaccgg cctcgacgag gtggtccagg
     5161 agcacgggac gacaccggta cggatcaccc ggatccccaa cgcccggctc gccggtgagg
     5221 tcgccaccgc caccgccctc gcggccgtcg actcaccggt ggccgggctc ccgcccctgg
     5281 acccgcacga cctgcgggac tgggccgacc ggcgcggcct cggcctgctg ctcaccctga
     5341 cggcgggcgt gcccgagtgc ttcgacgcgg tggtcttccc cgccggtacc gaagccgggc
     5401 ggacgtactc cggagggttc acgcccaccg ggcgccccga gcggatgctg gcgaacgacc
     5461 cggccggggc gcgggagatc ggcgtcctcg tcgccgggct ccgcgaccac gcccaggaac
     5521 ggctgccgga gtacatggtg cccgcggccg tggtcgcgat cgccgaagtg cccctgaccc
     5581 ccaacgggaa gctggaccgg caggcgctgc ccgtgcccga ctacgccggt gtggcgacgg
     5641 gccggccgcc gcggacaccg caggaagagg tgctctgcgc gctgttcgcc gaggtcctcg
     5701 gcatcgaccg ggtgggcatc gacgacaact tcttcgccct cggcgggcac tcgctcctcg
     5761 ccacccggct gatcagccgg atccgcgccg aactgggcgc cgaggtcccg atccgcgcgg
     5821 tcttcgactg tcccaccgtc gtggaactgg tcgaacggat cgccccggga gcgcgcgtcc
     5881 gctccccgct gcgccgggcg gcacagcggc cggagcagcc gcccctgtcc ttcgcgcagc
     5941 gccgcctgtg gttcatcgac cggttcgagg ggccgtcggc gacgtacaac atcccgttcg
     6001 tgctgcggct caccggcgcg ctggacgtgg cggcgctgga gaacgcggta cgggacgtcg
     6061 tgtcccggca cgagatactg cggacgctga tcgccgagtc cggtgacgga gtgccgtacc
     6121 agcgggtgct gcccgcggca ccggcaccgg tggacctgca cgtcgtcgag tccgccccgg
     6181 aggcggtggc ggacgccgtg gcggcggtcg ccgcccggcc gttcgacctg gccacggaga
     6241 taccgctgcg ggtgaccgtg gtccgcggcg ccgccgacga gcacgtgctg gtcctcgtcg
     6301 tccaccacat cgccggggac ggcgagtcga tgggtccgct ggcgcgcgac ctgggcacgg
     6361 cctacgccgc ccgacggcac ggcgagcggc cggactggcc ggagccgccg gtgcagtacg
     6421 tcgactacac cctgtggcag cgggaactgc tcgccgacga gtccgacccc gacggcgtcc
     6481 tcgccacgca gctcaggtac tggcgggacg aactggcagg cgtgccgcag ccgttgcagc
     6541 tcccgacgga tcgcccccgg ccgccggtgg cgagccgccg tggcgacctg gtggcgttcg
     6601 agctcgaccc ggacctggtc accgccgtgg aggaactcgc ccgcgcgcag ggcgcgacgg
     6661 tgtcgatggt cctccagtcg gccgtggcgg tcctgctgca ccacctgggc ggcggcgagg
     6721 acatcaccgt cggatccccg atcgcgggcc gcaccgacgc cgcgctcgcg gagctggtgg
     6781 gcttcttcgt caacacctgg gtgctgcgcg ccgacctgtc cggaaacccg agcttccagg
     6841 gcctcctcgg gcaggtgcgc gagaaggccc tggccgccta cgagaaccag gacgcgccct
     6901 tcgagcgcct ggtggagctg ctcaagcccg accgctccac cgcctaccac ccgctgttcc
     6961 aggtgatgtt cgcctggcag aacatggccc gcgaggactt cgcgctcgac ggcctgcgcg
     7021 tggacctcga gcacccgtcc accgacaccg cgaagttcga cctgttcttc aacatggccg
     7081 acatccccgg cctcggcgtg gtcggtcacc tcgagtacgc gacggacctc ttcgaccgtg
     7141 ccacggtcga ggccctcgcg gcccggttcg cacgggtcgt acagcaactc gtcaccagcc
     7201 ccggccggcc gatcggggcg atcgtggacg tgctggacgc ggcggagcgg gagctggtga
     7261 tccaccggtt caacgacacg gcggcgccga cgcccgacgt gacggtcccc gccctgttcg
     7321 agcggcaggc cgccgccacc ccggacgcgg tggcggtggt ctccggcgag cggaccctca
     7381 cctaccgcga gctggacacg cgcgcgaacc atgtggcgcg cgagctggcg gcacgcggag
     7441 tgggcccgga gacagtggtg ggactcgcgc tgccgcgctc ggccgacctg gtcgtggcac
     7501 tgctcggcgt gctgaaggcg ggcggcgcgt atctgccggt cgacccgaag taccccagca
     7561 cgcggctcga cttcatcctg tcggactccc gcccccggct gttcctgacg gacgcggaga
     7621 ccgtgggagt gctgccggac gacggcactc cgcgcctgtt cgtcggcgac gccgaaaagg
     7681 cgggcgccga cgccgggaac gcgggcaccg acgccgggca ggcgcggccg cggccgcaca
     7741 acgcggcgta cgtgatgtac acctccggtt cgaccggcac gcccaagggt gtgaccatca
     7801 cgcaccacaa cgtggtcaac ggtgtcctgc ggctcgccga gcgggtgggc atcgaaccgg
     7861 gcacgcgcgt cctcgcgggc acctcggtga acttcgacgt gtccgtcttc gaggtgttca
     7921 cgacgctgac gcacggcggc tgcgtcgaag tcgtccgcga cgtccttgag ctggcggacc
     7981 gggaagactg gcagggcggt gtgatcagca ccgtgccgtc cgtcttcgcc gaactcgtcg
     8041 acgacatcgt cggcaccgtc gccgtcgacg ccgtcgtctt cgccggagaa gccctccctg
     8101 cgtccctggc ggagcgggtg cgccaggcct tcccgggcgt gcgggtcgtc aacgcctatg
     8161 ggcagacgga gagtttctac gcgacgacgt tccagttgtc gtccggtgcg gagtgggacg
     8221 ggtcgggcag tgcgcccatc ggttcgccgt tggggaacat gcgggcgtat gtgctgggtc
     8281 ctgggctgct tccggtgccg ccgggtgtgg tgggggagtt gtacgtcgcg gggagtgtgg
     8341 cgcggggcta tcacggtcgc gcgggtctga cggcggagcg cttcgtcgcg gaccccttcg
     8401 gtgggcccgg cgcgcggatg tatcgcacgg gtgacctggc gcggtggacc gctgagggcc
     8461 aactggagta tgtggggcgt gatgacgcgc aggtgaaggt gcgcggcttc cggatcgagc
     8521 cgggtgaggt ggaggcggcg ctgaccgcgc atcccggtgt gtcccaggcc gtggtcgtca
     8581 cgcgcacggg tcagggcacg aaacaactcg tcggctatgt cgtccccacc ggagcggacg
     8641 acgccaccgg tgacaccgag ggcctgagcg acgacgccat cgacctcacc agcggtgtcg
     8701 acaccgccga gctgcggcgt tttgtggcgg ggcggttgcc ggagttcatg gtgccgtcgg
     8761 tgttggtgat gctggatcgg ttgccgttgg cgccgaacgg gaagctggac cggtcggggt
     8821 tgccggagcc ggagttcggt ggtggtgcgt accgggcgcc gggttcggtg gtgg
//
