LOCUS       NZ_BMVR01000021        25327 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence21, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000021
VERSION     NZ_BMVR01000021.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 110132)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 71969
            Orig. end                         :: 97296
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25327
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="aureonuclemycin"
                     /region_number="2"
                     /rules="(her4 and her5 and her6 and her7)"
                     /tool="antismash"
     cand_cluster    1..25327
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(her4 and her5 and her6 and her7)"
                     /kind="single"
                     /product="aureonuclemycin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25327
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15327](+)"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15327
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(her4 and her5 and her6 and her7)"
                     /neighbourhood="10000"
                     /product="aureonuclemycin"
                     /protocluster_number="1"
     misc_feature    10..25
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.36"
                     /tool="antismash"
     misc_feature    370..386
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.62"
                     /tool="antismash"
     gene            complement(508..1665)
                     /locus_tag="IE274_RS36160"
                     /old_locus_tag="GCM10010349_73830"
     CDS             complement(508..1665)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644257.1"
                     /locus_tag="IE274_RS36160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73830"
                     /product="acyltransferase family protein"
                     /protein_id="WP_372447258.1"
                     /transl_table=11
                     /translation="MAALDGLRGFAVVAVLLFHAGYLNGGFLGVDLFFVLSGFLITGLL
                     LGEATGRGRIPLAAFWVRRARRLLPALCCVVVVTVLATWAWGSTAQLRFALDDLPWVGA
                     QAVNWHYIAEQVGYWNASDTRVFAHLWSIGVEWQFYLAWPLVVAVAARGRFGERIVASL
                     AGAGALVSLALTVSLGAAVDTTRAYEGTDTRAAALLLGALVATAPVRDLARRVPRRAAD
                     LVCLALACGLAVAWAVTEGEKAPLLFEGGLFVHSLAAAVLIVLMARVPGTWAARIAGSR
                     LPRGLGKLSYSLYLWHWPVYLLLLPRLSALGGPGGTAVAIGVSLVAAAVTTRFVEDPVR
                     ARAGWARGGRGWIAVVAPAVAGVVLWAAVPEPVTGAGTVDVDQLR"
     gene            complement(1793..2617)
                     /locus_tag="IE274_RS36165"
                     /old_locus_tag="GCM10010349_73840"
     CDS             complement(1793..2617)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644258.1"
                     /locus_tag="IE274_RS36165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73840"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_190120185.1"
                     /transl_table=11
                     /translation="MNSKRTFRTRSSRRSARHALSGVAAVAALGLALVGCGGKDSGTRD
                     EGKSRATASTDTKVLWLGDSIAGAEAPALGAALKASGVEFKDSSSDGGGTIVDSGEKIT
                     QMISGDTWKQLAKDIKSFRPTVVAYQVTTYDWGSPARQRAAYEKAVGTVEDAGAKLVFV
                     APPPIKIDGFYKPHEAQMRTAPKVAAEVAGKSGGAAAFFDASQVWGTDHAAQEALRAPD
                     GIHNCQQGAAAFARWFTGTLGKQEKFTPASVDSWAQKSWTGDKRYGNLRCAA"
     misc_feature    2668..2684
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            2842..3309
                     /locus_tag="IE274_RS36170"
                     /old_locus_tag="GCM10010349_73850"
     CDS             2842..3309
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014172627.1"
                     /locus_tag="IE274_RS36170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73850"
                     /product="nitroreductase family deazaflavin-dependent
                     oxidoreductase"
                     /protein_id="WP_190120186.1"
                     /transl_table=11
                     /translation="MPVESEYEPSPVHWVREQVELYESSDGAQGGTLRDTGLPIVVATT
                     RGVRSGKIRKIPLMRVEHEGRYAAVASNGGVPTHPVWYYNIKADPHVKLQDGAVRQDMT
                     AREVTGDEKAAWWERAVAAYPPYAEYQEKADREIPVFVLEPVPAEGPDGPA"
     gene            complement(3330..6284)
                     /locus_tag="IE274_RS36175"
                     /old_locus_tag="GCM10010349_73860"
     CDS             complement(3330..6284)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024758.5"
                     /locus_tag="IE274_RS36175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73860"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_190120187.1"
                     /transl_table=11
                     /translation="MSAEAADPGPGIDPRRIAEIIVETGSGGRRGSGYLISSGSVLTAA
                     HVVADATRTVVRCCADRPGEWSAPAAVTWAHEDTDLAVLTVVPPAGGLPVTDPARFGRI
                     ADDRHGVVGVHAVGFPLWKRRHRDGAYFRELHQADGTVAALSNLRTGTLEMTVKPADAD
                     PDPATSPWAGMSGAAVWAGGTIIGVVAEHHRPEGPRRLTAVRLDYALRRLGAAVRAELA
                     RLLGLADPEDLPLALPGDSGDEEPAAVRVVGVPVAYGIELFKNRTRERDEIARHLSDPT
                     IRMVTVIGRRGIGKSALAAKVMDLLDRGEWPGPTPGPQPSGLVNLSTRTSGISLERLYF
                     GCAQLLGSEREAHLRTVWAADGTTQDRLDALLAAMGDRLIVILMDNLEDLLHDDCTIAD
                     EELAVFLDWLFRAPRAPLRLLVTSQEPVRLAPELRRFAAHVELSEGLMPAEAAALLREL
                     DRDGSLGIAGLSDDELLHAAVRVHGVPRALELLVGVLADETELLPSLRDVLEDFTRREN
                     VVADLAQDRYKQLDEPARAVLGVLAALRAPAAPSAVEEILHGLDPDLPASPVLTSLVRA
                     HLVSLDRASRTVALHPLDADIACARMPWHGPLGRQAVEREIASWYARQARPQGTWRTLE
                     DIEPHRRRFDHLVRAGDHDAAARVLCDISEWLVWHGSVLAAVKMHHDVDGHIGDERVRL
                     AHTVAYGHARLSAGPMRQAAELFAEAVTLAESLGDRPALQNALFGLGDAHRQLGDLAAT
                     VASLARATELARELGDTEREVHALLSASLAHSYLGDGERALTCADQLGARAEASGDPLT
                     TARAGNARTIALLTLGRWRETADAGAETARAYRAAGSQEAIAYALNARGIALLALDDAA
                     QAASVLEEARHEASCMENPRAEGVCLFNLAWAFWCDDRLEECATTADRASTALEIAGAT
                     QAAAARSLAAAARACPDDPRSAAESLTRGAAALDGNAEVIAPAWLADHARRLAG"
     gene            complement(6274..6585)
                     /locus_tag="IE274_RS36180"
                     /old_locus_tag="GCM10010349_73870"
     CDS             complement(6274..6585)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040332.4"
                     /locus_tag="IE274_RS36180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73870"
                     /product="trypco2 family protein"
                     /protein_id="WP_190120188.1"
                     /transl_table=11
                     /translation="MDDAVELEVMIAQLRAALGRAMADGDGEGIRFQAEKLELELTVGV
                     ERSKEPGAKVRFWVFDVHHSARSAHTATQRITLTLQPVRADAPDRPALISDAELPDER"
     gene            complement(6781..9693)
                     /locus_tag="IE274_RS40160"
                     /old_locus_tag="GCM10010349_73880"
     CDS             complement(6781..9693)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540477.1"
                     /locus_tag="IE274_RS40160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73880"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_190120189.1"
                     /transl_table=11
                     /translation="MFVGREREQHKLGRIAAALNEGSSGSLVVRGVAGIGKSALLQHLR
                     NTLNPEVQVLTAVGVESETELSFAALHQLLLPLLPDADRLPPPQSAALRSAFGLQSAPA
                     DRFLVALGALTLLSEASRGNPLLVLIDDAQWLDTPSADALRFVARRLGAEAVGIVFAAR
                     DGIRPFAAPGLPELRVGPLDTSAARTLLTHHLPAAAPVTRDRLLREAHGNPLALAELPR
                     ALSRPQLDGAAVLPEELPLTERLQRLYRHRVHGLLARPGNALVLAATEGDGDLAVILRA
                     AEDTDRAMDELGAAESAGLLDLDQHRLHFRHPLVRSAFYQGTPLNHRRAAHIALAEALD
                     PGDDRHVWHRAAAAMAPDGQVCHLLADLADRVRDTGGVATATRALRRAADLAPSSRLRA
                     HLLIDAADCAWTAAETTQAHALLTEAEPLADHPTLRARLMRVRGAIAHASSDPARACAT
                     LLEGAALVQDTDPHLARESLAMAARAAWVADDPGRLAQIAGVLDDLAAADAAGVDAAGV
                     DGTGVDGTGAGAAGLDGIAPGAARLDGTAPGAAAPGAPAEAALAASAPHDAFVSHLRYL
                     SGLATDSTTELGPASPEGAADVRGARIPETWLDPDDPHPWVWPPTFLPHLLNATLSWRD
                     DLERAVGTLRRHGAVGALPMSLAPLVALQLVTGPWLEATAQGSEALALAQETGQLGAAS
                     HLRAMLAWMAAAQGDSARCQILARECLDVAVPRRIASAVTLAHWALGLNGLAERRPGHA
                     AQALGEVCSPGGAAPHFMLRRLVLPDYVEAATRAGQHQRAEEALRRLGGPQAHDGPHLL
                     AARLRCQALLAQGDRAEELFTTALEKADTSPFEAGRTRLLYGERLRRDRRIKLAREQLR
                     LAEIQLHRIGARPWAQLARMELAAAGDRSAQAAAPARTSDHAALTVREQQVVRLAAQGL
                     SNGEIGARLFLSPRTVGYHLYKAFPKLGVTSRSQLLRTTQ"
     gene            10001..11731
                     /locus_tag="IE274_RS36190"
                     /old_locus_tag="GCM10010349_73890"
     CDS             10001..11731
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321747.1"
                     /locus_tag="IE274_RS36190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73890"
                     /product="hypothetical protein"
                     /protein_id="WP_229910039.1"
                     /sec_met_domain="her4 (E-value: 6.2e-274, bitscore: 902.2,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHVQHEEEVSQCGPSGPFEVVDGCLDPDAVLTAVRTVIAGQTWP
                     REPARLHEEGPGRCTVRVEGVVLTVRSAPLPAGPPGTLDAVTSAGPAGSVASVGHTGSV
                     ASAGHTGSVASAAYAHRVLVSASGPLPPRAQSVFAALVAELGRRAQCYTQAEADTIVAA
                     MPLLGRYDAPEPAFADWALIFRDHYVENSVGLLLAMERAGIAPEWIYALSKGDRTLHRD
                     RVHTWFLHRGYASDVLDNSVINGTADEAARAEALAVDARVEDFIRRAHAVGRKVLVIDD
                     GGLLAQGRGSDNGLVEPVDAAIELTVSGLKRIHDAPGRLAVPVLNLARSQLKSRLGYNE
                     IADSCVRRLRAIVPGEKFIGRHVLVLGYGTLGNRVAHALRALGCRVHVVDTDILALITA
                     AEDGFETHRTIAEALTDHRPFLVIGSSGGTAVTERDVPLLADGTLLAGFATKDFSVLSE
                     GRCGATSTPVPYVGVRHHLPHGATVTLLGDGRSLNLYEYEGIANRGYDAYRAGTLLAAK
                     RLCRDVDSLTPGVHLDVVDELIDEAGLFPAYYDCYLREGRPAGTGPYDTTTPVGDAYVR
                     "
     misc_feature    10040..10054
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.07"
                     /tool="antismash"
     gene            11721..12839
                     /locus_tag="IE274_RS36195"
                     /old_locus_tag="GCM10010349_73900"
     CDS             11721..12839
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321766.1"
                     /locus_tag="IE274_RS36195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73900"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_190120191.1"
                     /sec_met_domain="her5 (E-value: 4.3e-174, bitscore: 571.3,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.8e-12, bitscore:
                     39.6, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSARTHVCIVGYGVAGQLHHRLLGGLGVRVSVVDPAAARLAPSLP
                     AYARIEDVPRHPPVDVWSVCTPTAAHVETAAAVLDRDPSARLLVEKPVCRSWEAPDLSA
                     LLAKYDESRLVVMDQYAHATAPDILRAAREEWAPGHPIDAVRVAFGKDRRADIASGRFV
                     DRDYGVFGYEWLHMLALLGTVLPPAVHDRYLATDPGCHDLGVAHEPELTSVAAHDRTRP
                     PGGPAVELYSTIVGPHAGPGCPAPAWYPRTATGAESRQRLVRVDAGPVSFRLDLDPVGL
                     PGGTPLPRNTHRLTMRRAEGAREWLIHDSPMENALRWALSTLFAPGPRSAPDLRGIARI
                     SRLADRARAQEQLPVGAPSPVLRTPTVEVNPS"
     gene            12836..14146
                     /locus_tag="IE274_RS36200"
                     /old_locus_tag="GCM10010349_73910"
     CDS             12836..14146
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her6"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941308.1"
                     /locus_tag="IE274_RS36200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73910"
                     /product="radical SAM protein"
                     /protein_id="WP_190120192.1"
                     /sec_met_domain="her6 (E-value: 3.1e-248, bitscore: 816.1,
                     seeds: 189, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVCLVIPSNPFDRYFIQLPLDAVTAAGQLRAAGHSVTIWDQRL
                     QDAPAAAEPFDVLVVYSAIADRAQCYPLDLGPVRAAVERAVARFPHARTVAVGPHGTQL
                     PESTRADLAVDHVAVGETDSATVGAVTDLLAGVTEPVLCDRSAPHNLLDSPAPRPKPYP
                     AVPLDSFAFPAFDLVPTADYTAEVISGGLPLPGPCGMVLAARGCTYGCTYCHLPFGTRM
                     RTQPLDRVVAEIDAQQNAGLEFVFFLDYVFGINRGFYSGLCERLDGRGLGWVGQTRAEI
                     VLKSDVTQWARAGCQGMWLGAESPAIADTGVHKRVTEEQIKQAVLKLRDAGIVPFAFVL
                     IGLPGDEACISGRLVDWAAEMPAWFGINQLYLRPGTTLYDQLAPEHNGGRMPTTWHEVE
                     EVTRHYRATYPIDLDAQQQRLTELPNFLGNSIVPTAG"
     gene            14152..15327
                     /locus_tag="IE274_RS36205"
                     /old_locus_tag="GCM10010349_73920"
     CDS             14152..15327
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     aureonuclemycin: her7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009321760.1"
                     /locus_tag="IE274_RS36205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73920"
                     /product="Gfo/Idh/MocA family protein"
                     /protein_id="WP_190120193.1"
                     /sec_met_domain="her7 (E-value: 1.6e-193, bitscore: 635.3,
                     seeds: 189, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.9e-26, bitscore:
                     85.7, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 4.1e-32,
                     bitscore: 103.4, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRFGIIGCGVLGSFLGRLLTHEQEGLPGVARLVAVAGRDPRRTK
                     DTAAALGCDPLTVTDLLARTDVDAVVVCTPSGTHADLGVRALRAGKHVLVEKPVEVTLD
                     AADRLLTAAQGSGLTLGVVSQHRFDPAVRLVRSAVAEGRFGRLTSLVVELPWWREQSYY
                     ASGSWRGTPDLDGGGALINQAVHLVDLAQHLAGPVAEVAAHTGLLAHHDIDVEDVASAS
                     LRFAGGALGVLLATTAAYPGRTARLAVHGDRGSAVLDNDELVYFHAAREGERAAAYGAF
                     GAGNQVADVLPPQRAEPRRDQGGLLYQPHRDQLSDFCAAVRAGRPPLADGDSARRALEV
                     VTAVYASARTGTPVRTGAPVHAGTPPRTSTPVPANRAAPPSGSPAPEGTSP"
     gene            15324..16265
                     /locus_tag="IE274_RS36210"
                     /old_locus_tag="GCM10010349_73930"
     CDS             15324..16265
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941303.1"
                     /locus_tag="IE274_RS36210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73930"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_190120194.1"
                     /sec_met_domain="PCMT (E-value: 4.4e-09, bitscore: 28.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETAASPPPATRSARTVARPATADERKAALAGLFDRSAPTYERV
                     GVNHFADLGQRLIGHADVLPGDRILDIGCGTGAVLVPAARATGTTGSAVGVDLSAGMVA
                     RSRAALREAGLTHAHAVVADAETIDWDAQGGVHPPADGTLDVVCAGISLFFLPHPRQAV
                     SRYRELLGPGGRLAVSWWGRPDPRWDPVFAASAPYGRGGSSHALPEDSPFRSVAALHAM
                     LEEAGYASVETVEEPCVTRFRGPHQWWDWVWSTAGRMFWEGVPAESRERAEAAVNAELD
                     RLRAPDGSLTSTSAVRFTVARAQRSPGSGAMR"
     gene            16262..17953
                     /locus_tag="IE274_RS36215"
                     /old_locus_tag="GCM10010349_73940"
     CDS             16262..17953
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941300.1"
                     /locus_tag="IE274_RS36215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73940"
                     /product="serine hydrolase"
                     /protein_id="WP_229910040.1"
                     /transl_table=11
                     /translation="MSGVGDVVRADAAPRADRGTGVDVPAPSPLFSARWLRCAADVTAA
                     EPPDGDSAVRLGLCLTDAPAGTAERVLVRADLPTGRLRFSDGDWGERPALVLTLSVADA
                     AVFLFGDGVRRVRLFERAGVRLEGVFLFVFFLDRMLQQDRSGVLARLRAVTAGLPPAGD
                     AAPHGRRPHPAPGRADATQEEYEEKEHEEEARRQAERILPGTLAVLRAELGRSTPGAQL
                     AVVHRASGTRLSVALGDCRPGVPFTRAALPIWYCCSKSVGAVAVGQLWERGLLDPLAPV
                     CAYLPWFTGDGRETVTLYQLLTHTSAVPMGLDPLHGTMAAPLALRRERLRTMTVPPDAR
                     PGTRIAYAPWWAWFLIAEVVRALDGRDYERYLTEEVLAPCGMDATRVVLSPREYRDTAD
                     RLPLIHLAGGGAPVQATHWYATEASCTRPIPGLNIRGPMSDLALFFEALMNGGQGRKGR
                     VLRPQTVLALTARHRVGLVDAFGNADWGLGFRNESHHLGEICTAFSRHASLRTFGHYGL
                     WTSSAFADPDAGLVVALHLNGKTWQEEHQTRMIAIGDALYKDLGLT"
     gene            18014..19129
                     /locus_tag="IE274_RS36220"
                     /old_locus_tag="GCM10010349_73950"
     CDS             18014..19129
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941298.1"
                     /locus_tag="IE274_RS36220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73950"
                     /product="methyltransferase"
                     /protein_id="WP_190120195.1"
                     /transl_table=11
                     /translation="MTDPAAPGPGAPDSPHAIIDLAVAFWKSKVLLSAVELKVFAALAE
                     RPATGTELRARLGITGRGGADFLDALVSMGLLERRDGVYQNAPLADRHLDPAKPATDIS
                     GYLEFLNAGFPCWAGLTEGLRTGGRLDFTRALAASGNTDGSGEAPTEPALVEADADSDT
                     FGEAFAAPDQVSGFLRAMTGYSMGANHALAETHDWRNVRTVADVGCAEGSLLAQILTRH
                     EHVEGIGFDLPVVEEGFTAHTKQLGIADRARFEGGDFFTGPLPTADVLVMGHVLHDWDL
                     DIKKMLIRKAYEALPAGGSLLIYESLIDDDRRDRTTGLLISLNVSLVSAGGLGYTGADC
                     RSWLAESGFAETSVRHLDGPEYLVVGTKRAD"
     gene            19242..20453
                     /locus_tag="IE274_RS36225"
                     /old_locus_tag="GCM10010349_73960"
     CDS             19242..20453
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="IE274_RS36225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73960"
                     /product="cytochrome P450"
                     /protein_id="WP_190120196.1"
                     /sec_met_domain="p450 (E-value: 7.1e-15, bitscore: 47.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPPHLPSGTAHQHGPLPDFLPTADGAAEVVPVVAPTGDRIWLVT
                     AFDLGRSVLTDERFSRAAAAAPEAPASHPMRPDPAALTSLDPPQHTRLRRLVNHPFTPR
                     AVAGLEEGIRRQARRLLAGRDRIDLVSQYAMPLSAATICRVLGVPKAEHTHFADLADRA
                     LGVTTGDFAEQGPARDALRAYIGELISRARRAPGEHVLGALATAYDEDGTLSHDELTAL
                     VELLLNAGYETSIGQLGLAVVTLLEHPEQWHRLAAAPHREAAAAVEELLRHTPVVPMSF
                     TRVARQDVRLGTVVVRAGEALVVSLLHANFDARAHRDPTRLDITRRPARHLTFGHGAHI
                     CLGAQLARTQLRVALAELAAAAPGLTPRTPLSALRWRQPEAVVRGPLALPVHLTATRAG
                     AVPG"
     gene            20524..21648
                     /locus_tag="IE274_RS36230"
                     /old_locus_tag="GCM10010349_73970"
     CDS             20524..21648
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638896.1"
                     /locus_tag="IE274_RS36230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73970"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_190120197.1"
                     /transl_table=11
                     /translation="METAEEIIRVTAGNDSPGAAVEDQQRQDASEAPRADVGATRFSVL
                     DRSRTREGHDPTQPLRDTVALAQELEALGYHRFWVSEHHGVPGVAGSAPTVLAAAVAGA
                     TRTIRVGTGGVMLPNHQPLVVAEQFGVLEALFPGRIDMGLGRSVGFTDGVRKALGRDKH
                     DADDFAAHLHELLGWFRGTSDTGVHARPAEGLSVPPYVLAIGEGARIAAEAGLPMVVGD
                     IRSRAKMLAAIERYRAAFRPSAWSDEPYVVISGSIAVAGSEEAARRLLIPEAWSLAYSR
                     THGTFPPLPSAESVEERAATGAMTDKERGFYESGLRGHLHGTEDRVAAELETLIKESGA
                     QEVLVTTSTYDREGLSDSFRRLARITGLRGPGAP"
     gene            21736..24117
                     /locus_tag="IE274_RS36235"
                     /old_locus_tag="GCM10010349_73980"
     CDS             21736..24117
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638895.1"
                     /locus_tag="IE274_RS36235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_73980"
                     /product="excinuclease ABC subunit UvrA"
                     /protein_id="WP_190120198.1"
                     /transl_table=11
                     /translation="MHSRPAHEHDPFVRVRGAREHNLRGVDVDVPRDVLAVFTGVSGSG
                     KSSLAFGTIYAEAQRRYFESVAPYARRLIHQVGAPKVGEITGLPPAVSLQQRRAAPTSR
                     SSVGTVTTLSNSLRMLFSRAGDYPAGAERLDSDAFSSNTAAGACPECHGLGRVHRTTEE
                     LLVPDPSLSVREGAIAAWPGAWQGKNLRDVLDTLGHDVDRPWRELPQADRDWILFTDEQ
                     PVVTVHPVREAGRIQRPYQGTYMSARRYVMKTFSDSKSQTLRTKAERFLASEPCPACGG
                     SRLRPEALAVTFAGRTIADLSALPLAELTKHLEAAAGSGAGAAGAETAEVLTGDLLARI
                     GTITELGLGYLSPDRPTPTLSSGELQRLRLATQLRSGLFGVVYVLDEPSAGLHPADTES
                     LLTVLDRLKAAGNSVFVVEHHLDVMRHADWLVDVGPHAGEHGGQVLHSGPVADLEAVAE
                     SATARFLFDRTPMTVRQVREPHGWLKVGPVTRHNLRGVTAEFPLGAFTAVTGVSGSGKS
                     TLIGALAEDPADLAGVDRLVCVDQKPIGRTPRSNLATYTGLFDVVRKVFAETDEARARG
                     YGVGRFSFNVTGGRCETCQGEGFVSVELLFLPSTYAPCPDCGGARYNPETLQVTHAGLT
                     VADVLDLTVEAAADFFADTPAALRSLRTLLDVGLGYLRLGQPATELSGGEAQRIKLASE
                     LQRVRRGHTLYLLDEPTAGLHPADVEVLVGRLHELVDGGNSVVVVEHDMAVVAGADWVV
                     DLGPEGGADGGRVVATGTPADAARATGSRTGPYLARALGR"
     gene            24386..24604
                     /locus_tag="IE274_RS36240"
                     /old_locus_tag="GCM10010349_73990"
     CDS             24386..24604
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS36240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_73990"
                     /product="hypothetical protein"
                     /protein_id="WP_307822189.1"
                     /transl_table=11
                     /translation="MSSSVLRQRLVELIEARLVHQTPDGHYVLTALGRQAHTALTPLVD
                     WSVTWAAELTEPSAESGTAATDAPEIP"
     misc_feature    complement(24655..24671)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.32"
                     /tool="antismash"
     misc_feature    24672..24687
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.25"
                     /tool="antismash"
ORIGIN
        1 ccggcgggct tgaccacgta gtcgtcggcg cccgcctcca ggccgatcac gacgtccatg
       61 tcgtcgccgc gtgcggagag gatgacgagg gggacccggc tggtctcgcg gatgcggtgg
      121 cacacgtcca ggccgctcat gccggggagc atcaggtcga ggagcacgag gtccggcttg
      181 aaggccgcca gtgcctccag gccgtcctcg ccggtgccga ccgcctcggt ctcgtgcccg
      241 ttgcgggaca ggcccaggac gacaccgcgg cgcacggccg gatcgtcctc gatcagcagg
      301 acacgggtca tacaggggtc cttccacggt gggcgggttt cccggcctcg ggtgggccat
      361 ccggtggatc gcccaatgta cgggcgggtg ggaggcgggg cgtgcgcggc ttggcgcggg
      421 cggcgcggct cggcgcgagc cgcacggctc ggcgctgctt gccgacgcgt accgctgggc
      481 tcttcctagg cgtgggcttc ctgggcgtca ccgcaactga tcgacgtcga ccgtccccgc
      541 ccccgtcacc ggctccggca ccgccgccca cagcacgact cccgccacgg caggcgcgac
      601 caccgcgatc catccccgcc cgccccgggc ccaccccgcc cgcgcccgca ccggatcctc
      661 gacgaaccgc gtcgtcaccg cggcggccac cagcgaaacc ccgatggcga cggcggtccc
      721 gcccgggccc cccagcgccg aaagcctcgg caacagcagc aggtacaccg gccagtgcca
      781 cagatacagg ctgtacgaga gcttgcccag gccgcgtggc aggcggctgc ccgcgatccg
      841 ggccgcccag gtgcccggca cccgggccat caggacgatc aacacggccg cggccagcga
      901 gtggacgaag agcccgccct caaagagcag gggcgccttc tcgccctcgg tcaccgccca
      961 cgccacggcg aggccgcagg ccagggccag gcacaccagg tcggccgcac ggcgcggcac
     1021 ccggcgcgcg aggtcgcgta ccggcgcggt ggccacgagc gcgccgagca gcagggccgc
     1081 ggcgcgggtg tcggtgccct cgtaggcgcg ggtggtgtcc accgcggcgc cgagcgacac
     1141 ggtcagggcg agggagacca gggcgcccgc cccggcgagc gaggccacga tccgctcgcc
     1201 gaaccggccc cgggcggcca ccgccaccac cagcggccag gccagataga actgccactc
     1261 cacaccgatg ctccacaggt gggcgaagac gcgggtgtcg gaggcgttcc agtagccgac
     1321 ctgctcggcg atgtagtgcc agttcaccgc ctgggccccg acccagggca ggtcgtcgag
     1381 cgcgaagcgg agctgcgccg tgctccccca cgcccacgtg gccagcacgg tcacgaccac
     1441 cacgcagcag agggcgggca gcagccgccg ggcccggcgg acccagaacg cggccagggg
     1501 gatccggccg cgccccgtcg cctcgccgag cagcagcccg gtgatcagga atccggagag
     1561 cacgaagaac aggtcgacgc cgaggaaccc gccgttcagg tacccggcgt ggaagagcag
     1621 gacggcgacg accgcgaagc cgcgcagccc gtcgagggcg gcgatatggg cacggcccac
     1681 gccactgggg cgcgccgcac ggtgccgacc cggcaccgtg cggtcctgcg cggtcgtggg
     1741 cgtgggcgct ggcaacggac gacgcgcggg catggggtcg gtggccgttc cgtcacgcgg
     1801 cacagcgaag gttgccgtag cgcttgtcgc cggtccagga cttctgcgcc caggagtcca
     1861 cggacgccgg cgtgaacttc tcctgcttgc ccagcgtccc ggtgaaccac ctggcgaagg
     1921 cggccgcgcc ctgctggcag ttgtggatcc cgtccggggc acgcagcgcc tcctgcgccg
     1981 cgtggtcggt gccccacacc tgcgaggcgt cgaagaacgc cgccgcgcca ccgctcttcc
     2041 cggcgacttc cgcggccacc ttgggggcgg tgcgcatctg ggcctcgtgc ggcttgtaga
     2101 acccgtcgat cttgatgggc gggggcgcca cgaacaccag cttggccccg gcgtcctcga
     2161 ccgtgccgac ggccttctcg taggcggccc gctgccgcgc cgggctgccc cagtcgtacg
     2221 tcgtgacctg gtaggcgacc acggtggggc ggaacgactt gatgtccttg gccagttgct
     2281 tccaggtgtc gccggagatc atctgcgtga tcttctcgcc gctgtcgacg atcgtgcccc
     2341 cgccgtccga ggaggagtcc ttgaactcca ccccactggc cttcagggcc gcacccaggg
     2401 cgggggcctc ggcacccgcg atggagtcgc ccagccacag caccttcgtg tcggtgctcg
     2461 ccgtcgccct gctcttcccc tcgtccctgg tgccggagtc cttccccccg catccgacca
     2521 gggcgaggcc gagcgcggcg acggcggcga ccccgctcaa ggcgtggcgg gccgagcggc
     2581 gggaggaacg ggtacggaac gtgcgcttgc tgttcatgcc tcccagcaca acagcccccg
     2641 agtgcccgac cgtccgccgt catcgtttgc tcatactccg ggcaaggagc gctcataaag
     2701 gccgccgccc gccccggggc acgtgcggtc ggcacccgct cggaagaaat aacacgcgcc
     2761 ccctgttacc ccagtggtcg acgggtcgac gaaggcaagc cctagcagga gccgaaggca
     2821 agcgacgacg aagggaccac gatgcctgtt gagagcgagt acgagccgag tccggtgcac
     2881 tgggtgcgcg agcaggtcga gctgtacgag agttcggacg gtgcgcaggg cggaacgctg
     2941 cgggacaccg gtctgcccat cgtggtcgcc acgacgcgcg gcgtgcgcag cggcaagatc
     3001 cgcaagatcc cgctgatgcg cgtggagcac gaggggcggt acgcggccgt cgcctcgaac
     3061 ggcggcgtcc cgacccaccc ggtgtggtac tacaacatca aggccgaccc gcacgtgaag
     3121 ctccaggacg gggccgtacg ccaggacatg acggcccgtg aggtcaccgg ggacgagaag
     3181 gccgcgtggt gggaacgcgc ggtcgccgcg tatccgccgt acgccgagta ccaggagaag
     3241 gccgaccgtg agatccccgt cttcgtactg gagcccgtgc ccgccgaagg gccggacggc
     3301 cccgcctgac ctcccgccac cgcgcgagct cagcccgcca gtcggcgggc gtggtcggcg
     3361 agccaggcgg gggcgatgac ctcggcgttg ccgtcgagtg cggcagcccc tcgcgtcagg
     3421 gactcggcgg cggaccgtgg gtcgtcgggg caggcgcggg cggccgcggc cagggaacgg
     3481 gccgcggcgg cttgggtcgc tccggcgatc tccagagcgg tcgaggcgcg gtcggcggtc
     3541 gtggcgcact cctccagacg gtcgtcgcac cagaacgccc aggcgaggtt gaacaggcag
     3601 acgccttcgg cccgggggtt ctccatgcac gaagcctcgt gccgggcctc ttcgaggacc
     3661 gaggctgcct gagccgcgtc gtcgagagcc agcagagcga tgcccctggc gttcaacgcg
     3721 taggcgatcg cctcctggct gcccgcggca cggtaggcgc gggccgtctc ggcgcccgcg
     3781 tcggcggtct cccgccagcg gcccagcgtg agcagggcga tggtgcgcgc gttgcccgcg
     3841 cgggcggtcg tgagcgggtc gccgctcgcc tcggccctcg cgcccagttg gtcggcgcag
     3901 gtcagcgcac gctcgccgtc gccgaggtaa ctgtgcgcga ggctggcgga gagcagcgcg
     3961 tgcacttcgc gctcggtgtc gccgagttca cgggccagct cggtggcacg ggccagcgag
     4021 gcgacggtgg ccgccagatc gccgagctgc cggtgggcgt ccccgaggcc gaacagcgcg
     4081 ttctggagcg cgggccggtc gccgagactc tcggcgaggg tcaccgcttc ggcgaacagc
     4141 tcggccgcct gcctcatcgg tcccgcgctg agccgggcat gtccatacgc gacggtgtgc
     4201 gcgagacgta cccgctcgtc accgatgtgg ccgtcgacgt catggtgcat cttgaccgcg
     4261 gcgagcaccg agccgtgcca gacgagccat tcgctgatgt cgcacagcac gcgtgcggcg
     4321 gcgtcgtggt caccggcccg cacgaggtgg tcgaaccggc gccggtgcgg ctcgatgtcc
     4381 tccagtgtcc gccaggtgcc ctggggccgg gcctggcgcg cgtaccagga tgcgatctct
     4441 cgttccactg cttgcctccc gaggggtccg tgccagggca tccgtgcgca ggctatgtcg
     4501 gcgtccagag ggtgcagggc gaccgtgcgg ctcgcccggt ccagggagac gagatgcgcg
     4561 cgcaccaggg acgtgaggac aggggacgcg ggcagatccg ggtcgaggcc gtgcaggatc
     4621 tcttcgaccg cgctcggcgc agcgggggcg cgcagcgcgg ccaggacgcc gaggacggca
     4681 cgcgccggtt cgtcgagctg cttgtagcga tcctgggcga ggtccgcgac gacgttctcg
     4741 cggcgggtga agtcctcgag tacgtcccgc aggctgggca gcagctccgt ttcgtcggcg
     4801 agcacaccga cgaggagttc cagcgcgcgg gggacgccgt gcacgcggac cgcggcgtgc
     4861 agcagttcgt cgtcggacag gccggcgatg ccgaggcttc cgtcgcggtc gagttcgcgc
     4921 agcagcgccg ctgcctcagc gggcatcagg ccctcggaga gttccacgtg ggcggcgaag
     4981 cgacgcagtt cgggcgcgag gcgcaccggt tcctggctgg tgaccaggag gcgcagcggg
     5041 gctcggggag cccggaacag ccagtcgagg aagacggcca gctcctcgtc ggcgatggtg
     5101 cagtcgtcat ggagcaggtc ctccaggttg tccatgagga tgacgatcag ccggtcgccc
     5161 atggccgcga gcagtgcgtc gagccggtcc tgtgtcgtcc cgtcggcggc ccagaccgtg
     5221 cgcaggtgtg cttcccgctc ggagccgagc agctgggcgc agccgaagta gaggcgttcc
     5281 agggagatcc cggacgtacg ggtggagagg ttcaccaggc cggacggctg cggacccggg
     5341 gtggggccgg gccattcacc tcggtcgagg agatccatga ccttcgcggc gagcgcgctc
     5401 ttgccgatac cgcgccgtcc gatgacggtc accatccgga tggtgggatc gctcaagtgg
     5461 cgggcgatct cgtcgcgttc gcgggtgcgg ttcttgaaca gctcgatgcc gtacgcgacg
     5521 gggactccga ccactcggac ggcagcgggc tcctcgtcgc ccgagtcccc gggcagggcg
     5581 aggggcaggt cctcggggtc ggcgagcccc aacagccggg cgagctctgc gcggactgcg
     5641 gcgccgagcc tgcgcaacgc gtagtcgagg cggacagcgg tgagccgacg cgggccttcc
     5701 gggcggtggt gttcggcgac cacgccgatg atggtgccgc ctgcccacac cgcggcgccg
     5761 gacatgcccg cccacggcga tgtggcgggg tcgggatcgg catcggccgg tttcacggtc
     5821 atttccagcg tgccggtacg gagattggac aaggccgcca cggtcccgtc cgcctggtgc
     5881 agctcacgga agtacgcacc gtcacggtgg cgccgcttcc acagcgggaa tccgacggcg
     5941 tgcacgccga ccacgccgtg ccggtcgtcg gcgatgcgcc cgaaacgagc cgggtcggtg
     6001 accgggagac ctcccgcagg tggcacaacg gtcagcacgg cgaggtcggt gtcctcatgc
     6061 gcccaggtca cggccgccgg cgccgaccat tcgccagggc ggtcggcgca gcaccgcacg
     6121 accgtcctgg tcgcgtcggc gaccacatgg gcggcggtca gtacgctgcc ggaggagatc
     6181 agatagccgg aaccgcgccg cccgccgctt ccggtttcga cgatgatctc ggcgatccgc
     6241 cgcgggtcga tcccgggccc ggggtccgcg gcctcagcgc tcatcgggca gctcggcgtc
     6301 cgagatcagc gcgggccggt cgggtgcgtc ggcacgcacc ggctggaggg tgagcgtgat
     6361 ccgctgggtg gcggtgtgcg cggagcgcgc ggagtggtgg acgtcgaaca cccagaaccg
     6421 caccttggcg ccgggctcct tgctgcgttc cacgcccacg gtgagttcga gttcgagctt
     6481 ctcggcctgg aaccgaattc cttcgccgtc cccgtcggcc atggcccggc ccaacgcggc
     6541 gcgcaactgg gcgatcatga cctccagttc caccgcgtcg tccacgctca gctccccgtc
     6601 tcgtaggcac cgaccggcga ccggccccac cggccacacg ctcgctgagc atacctacgg
     6661 accgtcaact gcgcgccgag cagcctggct tgccagcgac ggggaggagc tcccgcgatc
     6721 ctaggcgagc gagtcgtggg ctctgggagg gagggggcgt gggccggtcc tcggcgagcg
     6781 ttactgcgtc gtacgcagga gttgggatcg ggacgtcacg ccgagcttgg ggaaggcctt
     6841 gtagaggtgg tagccgacgg tgcgggggct gaggaagagg cgggcgccga tctctccgtt
     6901 gctcaggccc tgggccgcca ggcgtacgac ctgttgttcg cggacggtga gggcggcgtg
     6961 gtcggaggtc ctggcggggg cggcggcctg ggcggaccgg tcgcccgccg cggccagttc
     7021 catgcgggcc agctgggccc agggcctcgc gccgatccgg tgcaactgga tctcggccag
     7081 gcgcagttgc tcgcgggcga gtttgatgcg acggtcgcgc cgcagccgtt cgccgtacag
     7141 gagacgggtg cggcccgcct cgaagggtga ggtgtcggcc ttttcgaggg cggtggtgaa
     7201 gagctcctcg gcccggtctc cctgggcgag cagggcctgg cagcgcagcc gggcggcgag
     7261 caggtgcggt ccgtcgtgtg cctgtggacc gcccaggcgg cgcaacgcct cctcggcacg
     7321 ctggtgctgg cccgcccggg tggcggcctc cacgtagtcg gggaggacca gtcggcgcag
     7381 catgaagtgt ggggccgcgc cgcccgggct gcagacttcg ccgagggctt gagcggcgtg
     7441 tccggggcgg cgttcggcca ggccgttcag gccgagggcc cagtgggcga gcgtcaccgc
     7501 gctggcgatg cggcgcggca cggcgacgtc gaggcactcc cgggccagga tctggcagcg
     7561 ggcgctgtcg ccctgggcgg cggccatcca ggcgagcatg gcgcgcagat ggctcgcggc
     7621 gccgagctgg ccggtctcct gggcgagggc gagcgcctcg ctgccctggg cggtggcctc
     7681 gagccagggt ccggtgacca gttggagggc gacgaggggg gccagggaca tgggcagggc
     7741 gccgaccgcg ccgtggcggc gcagggtgcc cacggcccgc tccaggtcgt cgcgccagga
     7801 cagggtggcg ttcaggaggt ggggcaggaa ggtcgggggc cacacccagg ggtgcgggtc
     7861 gtcggggtcg agccaggtct cggggatacg ggcgccgcgc acgtcggcgg cgccctccgg
     7921 gctagcgggc ccgagctccg tggtggagtc ggtggcgagg ccgctgaggt agcgcaggtg
     7981 ggagacgaag gcgtcgtggg gggcgctcgc ggcgagggcg gcctctgcgg gggcgcccgg
     8041 tgcggcggcg cccggcgcgg tgccatccag tcgagcggcg ccgggtgcga tgccgtccag
     8101 tccagcggcg cccgcaccgg tgccgtccac accggtgccg tccactccag cggcgtccac
     8161 accggcggcg tccgccgccg ccaggtcgtc caggaccccg gcgatctgcg ccagccgtcc
     8221 ggggtcgtcg gcgacccacg cggcgcgggc tgccatggcc agggactcgc gggcgaggtg
     8281 cgggtcggtg tcctggacga gggcggcgcc ttcgaggagg gtcgcgcagg ccctggccgg
     8341 gtcgctggag gcgtgcgcga tggcgccgcg cacccgcatg aggcgggccc gcagggtggg
     8401 gtggtcggcc agcggctcgg cctcggtgag cagggcgtgg gcctgggtgg tttcggcggc
     8461 ggtccaggcg cagtcggcgg catcgatgag caggtgggcg cgcaggcggc tggacggcgc
     8521 gaggtcggcg gcgcggcgca gcgccctggt ggcggtggcg acgccgcccg tgtcccggac
     8581 ccggtcggcg aggtcggcca ggaggtggca gacctggccg tcgggggcca tcgcggcggc
     8641 ggcccggtgc cagacgtggc ggtcgtcgcc ggggtcgagg gcctcggcca gggcgatgtg
     8701 ggcggcgcgg cggtggttga ggggggtgcc ctggtagaag gcggagcgga ccagggggtg
     8761 gcggaagtgc aggcggtgct ggtcgaggtc gagcagtccg gcgctctccg cggcgccgag
     8821 ttcgtccatg gcccggtcgg tgtcctcggc ggcgcgcagg atgacggcca ggtcgccgtc
     8881 gccctcggtc gcggcgagga cgagggcgtt gccgggccgg gcgagcaggc cgtggacgcg
     8941 gtgccggtag aggcgctgca ggcgttcggt gagcgggagt tcctcgggca ggaccgcggc
     9001 gccgtcgagc tgggggcggc tgagggcgcg cgggagttcg gccagggcga gggggttgcc
     9061 gtgggcctcg cgcagcagcc ggtcgcgggt gacgggggcg gccgccggga ggtggtgggt
     9121 gagcagggtg cgggcggcgg acgtgtccag cgggcccacg cgcagttcgg gcaggcccgg
     9181 tgcggcgaag gggcggatgc cgtcccgggc ggcgaagacg atgccgacgg cttccgcgcc
     9241 caggcggcgg gcgacgaacc gcagggcgtc cgcggagggg gtgtcgagcc attgcgcgtc
     9301 gtcgatcagg acgagcagcg ggttgccgcg ggaggcctcg gacaggaggg tcagcgcgcc
     9361 gagggcgacc agaaaccggt cggcgggggc gctctgcagg ccgaaggccg aacgcagggc
     9421 ggcgctctgg ggcggcggca gccggtccgc gtcggggagc aggggcagca gcaactggtg
     9481 cagggcggcg aaggagagct cggtctcgct ctcgacgccg accgcggtca gtacctgcac
     9541 ctccgggttc agggtgttcc gcaggtgctg cagcagcgcg ctcttgccga tcccggccac
     9601 ccctcggacg acgagggacc cgctgctccc ctcgttcaac gcggcggcga tgcgcccgag
     9661 tttgtgctgt tcccgctccc gaccgacgaa catgccagat tgccctccgc tgtgaccgcc
     9721 cccatcgact gatgcattga ctgatgctcc gcgatctatc ccgtccgtat gacggatggc
     9781 cgaaggtata tgccaccaac tgggggaatt tttatccctt ttgtcgcttg cgggaagctc
     9841 gtcgcccgac agatgcccgg acacccgcac ccggcggaga ctgaccgccg aggccgaccg
     9901 caactgctgc gcacagcgca acggcggggc cgcgtgaggc tgttctcaca aggaatgcac
     9961 gcctggcatg ggtggacata tgtcgctatc tgaagtgggt ttgaatcacg ttcaacacga
    10021 ggaggaggtg tcgcagtgcg ggccgtccgg cccgttcgaa gtggtggacg gctgtctcga
    10081 tcccgacgcc gtcctgacgg cggtgcgtac ggtcatcgcc gggcagacct ggcccaggga
    10141 accggcccgc ctgcacgagg aggggcccgg ccggtgcacg gtgcgcgtcg agggcgtcgt
    10201 cctgacggtg cgcagcgccc ccttgcccgc gggaccaccg ggaacgctcg acgccgtgac
    10261 gtccgcaggg cccgcggggt ccgtggcgtc cgtggggcac acgggatccg tggcgtccgc
    10321 ggggcacaca ggatccgtgg catccgccgc gtacgcgcac cgggtgctgg tgtcggcgtc
    10381 cggaccgctg ccgccgcgcg cacagtcggt gttcgccgcg ctcgtcgcgg agctggggcg
    10441 gcgcgcgcag tgctacaccc aggccgaggc cgacacgatc gtggcggcga tgccgctgct
    10501 cggccgctac gacgctcccg aaccggcctt cgccgactgg gcgttgatct tccgcgacca
    10561 ctacgtggag aacagcgtgg gcctgctgct cgccatggag cgggccggaa tcgcacccga
    10621 gtggatctac gccctctcca agggcgaccg cacgctgcac cgggaccggg tgcacacctg
    10681 gttcctgcac cgcggctacg ccagcgacgt gctggacaac tcggtgatca acgggacggc
    10741 ggacgaggcc gcccgggccg aggcgctggc cgtcgacgcc cgcgtggagg acttcatccg
    10801 ccgggcgcac gccgtcggcc gcaaggtcct cgtcatcgac gacggcgggc tgctcgccca
    10861 ggggcgcggc agcgacaacg gtctggtcga gccggtggac gcggccatcg agctgaccgt
    10921 cagcggtctc aagcgcatcc acgacgcgcc gggccgactg gccgtgcccg tcctgaacct
    10981 ggcccgctcg cagctcaagt cgcgcctggg ctacaacgag atcgccgact cgtgcgtgcg
    11041 ccggctgcgc gccatcgtgc ccggcgagaa gttcatcggc cgccatgtgc tggtcctcgg
    11101 ctacggcacg ctcggcaacc gcgtggccca cgccctgcgc gcgctcggct gtcgcgtgca
    11161 cgtcgtggac accgacatcc tggcgctcat cacggccgcc gaggacggct tcgagacgca
    11221 ccgcaccatc gccgaggcgc tcaccgacca ccgccccttc ctcgtcatcg gcagcagcgg
    11281 cggcacggcc gtcaccgagc gggacgtccc gctgctcgcc gacggcacgc tcctggccgg
    11341 tttcgcgacc aaggacttca gcgtgctcag cgagggccgc tgcggcgcga cctcgacgcc
    11401 cgtgccctac gtgggcgtgc gccaccacct gccgcacggc gcgacggtca cgctcctcgg
    11461 cgacggccgc tcgctcaacc tgtacgagta cgagggcatc gccaaccgcg ggtacgacgc
    11521 ctaccgggcc ggaaccctgc tcgcggccaa gcgcctgtgc cgggacgtgg actccctcac
    11581 cccgggagtg cacctcgacg tcgtcgacga actcatcgac gaggccggtc tcttccccgc
    11641 gtactacgac tgctacctgc gcgaagggcg gccagcgggc accggcccgt acgacaccac
    11701 gacacccgtg ggggacgcct atgtccgcta ggacgcatgt gtgcatcgtc ggctacggcg
    11761 tcgcgggaca actgcaccac cggctgctcg gcgggctcgg cgtgcgcgtc tcggtcgtcg
    11821 acccggcggc cgcccggctc gcgccgtccc tgcccgcgta tgcccggatc gaggacgtgc
    11881 cacgccatcc tccggtcgac gtgtggtcgg tgtgcacgcc caccgccgca cacgtggaga
    11941 cggccgccgc cgtcctggac cgggacccgt cggcccgtct cctcgtcgag aagccggtgt
    12001 gccgctcctg ggaggccccc gacctgtccg cgctgctcgc caagtacgac gagagccgcc
    12061 tggtggtcat ggaccagtac gcgcacgcca cggcgcccga catcctcagg gccgcgcgcg
    12121 aggagtgggc gccgggccac ccgatcgacg cggtgcgggt cgccttcggc aaggaccggc
    12181 gcgcggacat cgcctcgggc cgcttcgtcg accgcgacta cggcgtgttc ggctatgagt
    12241 ggctgcacat gctcgccctg ctcggcacgg tcctgccgcc cgccgtgcac gaccgctacc
    12301 tggccaccga ccccggctgc cacgacctcg gggtcgccca cgagccggag ctgacgagcg
    12361 tcgcggccca cgaccggacc cgcccgccgg gcgggcccgc ggtggagctg tactcgacga
    12421 tcgtcggccc gcacgcgggg cccggctgcc cggcccccgc ctggtacccg cggacggcca
    12481 ccggcgcgga gagcaggcag cgcctcgtcc gggtcgacgc cggtccggtc tccttccgcc
    12541 tcgacctcga cccggtcggc ctgcccggcg gcactcccct gccgcgcaac acgcaccgcc
    12601 tgaccatgcg ccgggccgag ggcgcccgcg agtggctcat ccacgactcg cccatggaga
    12661 acgccctgcg ctgggccctg tccacgctct tcgccccggg cccgcgctcc gcaccggacc
    12721 tgcgcggcat cgcccgcatc agccggctcg cggaccgggc ccgcgcccag gagcagctgc
    12781 ccgtcggcgc gccgtcaccg gtgctccgaa ccccgaccgt ggaagtgaac ccgtcatgag
    12841 cagcgtctgc ctcgtcatcc ccagcaatcc cttcgaccgg tacttcatcc aactgcccct
    12901 ggacgcggtg accgccgccg ggcaactgcg ggccgcgggc cactccgtga ccatctggga
    12961 ccagcgcctg caggacgctc cggccgccgc ggaaccgttc gacgtcctcg tcgtctacag
    13021 cgccatcgcg gaccgggccc agtgctaccc cctggacctc ggcccggtgc gggcggccgt
    13081 ggagcgggcc gtcgcccgct tcccgcacgc ccgtacggtc gcggtcggcc cgcacggcac
    13141 ccaactgccc gaatccaccc gcgccgacct cgccgtggac cacgtggccg tcggcgagac
    13201 cgactcggcg accgtcggcg ccgtcaccga cctgctggcg ggagtcacgg agccggtcct
    13261 gtgcgaccgg agcgcgccgc acaacctgct cgactccccc gcgccgcgcc cgaagcccta
    13321 ccccgccgtg cccctggact ccttcgcctt ccccgccttc gacctggtgc ccaccgccga
    13381 ctacaccgcc gaggtcatct ccggcggcct gccgctgccg ggcccgtgcg gcatggtcct
    13441 ggccgcccgc ggctgcacgt acggctgcac ctactgccac ctgccgttcg gcacccgcat
    13501 gcgcacccag cccctggacc gggtggtcgc ggagatcgac gcccagcaga acgcgggcct
    13561 ggagttcgtg ttcttcctgg actacgtctt cggcatcaac cgcggcttct acagcgggct
    13621 gtgcgagcgc ctcgacggtc gcggtctggg ctgggtgggg cagacccggg cggagatcgt
    13681 gctcaagagc gatgtgacgc agtgggcgcg ggcgggctgc cagggcatgt ggctgggtgc
    13741 cgagtcaccc gcgatcgccg acaccggcgt gcacaagcgg gtcaccgagg agcagatcaa
    13801 gcaggcggtc ctgaagctgc gggacgcggg catcgtgccg ttcgcgttcg tcctgatcgg
    13861 cctgccgggc gacgaggcgt gcatctccgg ccgactcgtc gactgggccg ccgagatgcc
    13921 cgcctggttc ggcatcaacc agctctacct gcgccccggc accacgctgt acgaccagct
    13981 cgcgcccgag cacaacggcg gccggatgcc gaccacctgg catgaggtgg aagaggtcac
    14041 ccggcactac cgcgccacct acccgatcga cctggacgcc cagcagcagc gcctgacgga
    14101 gctgccgaac ttcctgggca actccatcgt cccgacggcg gggtgaggca cgtgctgcgc
    14161 ttcggcatca tcggctgcgg tgtgctcggc tcgttcctgg ggcgtctcct cacccacgag
    14221 caggagggcc tgcccggcgt ggcccgcctg gtcgcggtgg ccggtcgcga tccgcggcgc
    14281 accaaggaca cagccgcggc cctgggctgc gatccgctga ccgtcaccga cctgctcgcc
    14341 aggaccgacg tcgacgccgt ggtggtctgc acgccgagcg gcacgcacgc cgacctgggc
    14401 gtgcgggcgc tgcgggcggg caagcacgtg ctggtggaga agccggtcga ggtcacgctc
    14461 gacgccgccg accggctgct caccgccgcg cagggcagcg gcctgacctt gggggtcgtc
    14521 tcccagcacc gcttcgaccc ggccgtccgc ctcgtcaggt ccgccgtggc cgagggccgg
    14581 ttcgggaggc tgacctccct ggtcgtggag ctgccgtggt ggcgcgagca gtcgtactac
    14641 gcgtccggct cctggcgcgg cacgccggac ctggacggcg gcggcgcgct gatcaaccag
    14701 gcggtgcatc tggtggacct ggcccagcac ctggccggtc cggtcgcgga ggtggccgcg
    14761 cacaccggcc tgctcgccca ccacgacatc gatgtcgagg acgtggccag cgccagcctg
    14821 cgcttcgccg ggggcgccct gggggtgctg ctcgccacca cggccgccta cccggggcgc
    14881 accgcccgcc tcgcggtgca cggggaccgc ggcagcgcgg tgctcgacaa cgacgagctg
    14941 gtgtacttcc acgcggcgcg cgagggtgaa cgggccgccg cctacggcgc gttcggtgcg
    15001 ggcaaccagg tcgccgacgt gctgccgccg cagcgggccg agccgcggcg cgaccagggc
    15061 ggactgctct accagccgca ccgtgaccag ctctccgact tctgcgccgc cgtgcgcgcg
    15121 ggccgcccgc cgctggccga cggggacagc gcccgccgcg ccctggaggt ggtgaccgcc
    15181 gtctacgcct cggcccgcac cggcacgccc gtccgcaccg gtgcccccgt ccacgccggc
    15241 acacccccac gcaccagtac gcccgtgccc gccaaccgtg ccgctccgcc cagcggttcg
    15301 cccgcccccg aagggacctc gccgtgaccg agaccgccgc ctctcccccg cccgccaccc
    15361 gctccgcccg gaccgtcgcg cggcccgcca ccgccgacga gcgcaaggcc gcgctcgccg
    15421 gtctcttcga ccgcagcgcg cccacgtacg agcgggtggg tgtcaaccac ttcgccgacc
    15481 tcgggcagcg tctgatcggc cacgccgacg tgctgcccgg cgaccggatc ctcgacatcg
    15541 ggtgcggcac cggcgccgtg ctcgtccccg cggcccgggc caccggcacc accggcagcg
    15601 cggtcggtgt cgacctgtcg gccggtatgg tcgcgcgctc ccgtgcggcg ctgcgcgagg
    15661 caggtctcac ccacgcccac gccgtggtcg cggacgccga gacgatcgac tgggacgccc
    15721 agggcggcgt gcacccgccc gcggacggca cgctggacgt cgtgtgcgcg ggcatctcgc
    15781 tgttcttcct cccccacccg cgccaagccg tgtcccgcta ccgggagttg ctcggccccg
    15841 gcggccgcct ggccgtgtcc tggtggggac ggcccgaccc ccgctgggac ccggtcttcg
    15901 cggccagcgc cccctacggg cgcggaggct cctcgcacgc gctgcccgag gacagcccct
    15961 tccgttccgt ggcggcgctg cacgcgatgc tggaggaggc cggttacgcc tcggtggaga
    16021 ccgtggagga gccgtgcgtg acccgtttcc ggggaccgca ccagtggtgg gactgggtct
    16081 ggtccaccgc ggggcggatg ttctgggagg gcgtgcccgc cgagtcgcgc gagcgggccg
    16141 aggcggcggt caacgccgaa ctcgaccggc tccgggcccc cgacggcagc ctgaccagca
    16201 cctccgcggt gcgcttcacc gtcgcacggg cgcagcggtc gccgggctcc ggggcgatgc
    16261 ggtgagcggg gtcggtgacg tggtgcgggc cgacgccgcg ccgcgggccg acagggggac
    16321 gggggtggac gtgcccgcgc ccagcccgct cttctccgcg cggtggctgc ggtgcgccgc
    16381 cgacgtgacg gccgccgagc cgccggacgg ggactcggcg gtgcgcctcg gcctgtgtct
    16441 gaccgacgct cccgccggga ccgcggagcg ggtcctcgtg cgggccgacc tgcccaccgg
    16501 gcggctgcgg ttcagcgacg gggactgggg cgagcggccc gccctggtgc tcacgctgag
    16561 cgtcgcggac gccgccgtgt tcctcttcgg cgacggggtg cggcgggtgc ggctcttcga
    16621 acgtgccggg gtccgcctcg agggcgtgtt cctgttcgtc ttcttcctgg accggatgct
    16681 ccaacaggac cggtccggtg tcctggcgcg gctgcgcgcg gtgaccgcgg gcctgccccc
    16741 ggccggggac gccgcgccgc acggccgccg cccgcacccg gcgccgggcc gggccgacgc
    16801 cacccaggag gagtacgagg agaaggagca cgaggaggag gcccgccgcc aggccgagcg
    16861 gatcctgccg ggcacgctgg ccgtcctgcg cgcggaactc ggccgcagca ccccgggcgc
    16921 ccagctcgcc gtcgtccacc gcgcgtcggg cacccgcctg tccgtggcgc tcggcgactg
    16981 ccgccccggt gtccccttca cccgcgccgc cctgcccatc tggtactgct gctccaagtc
    17041 ggtgggcgcc gtggccgtgg gccagctgtg ggagcggggc ctgctcgatc cgctggcgcc
    17101 cgtctgcgcg tatctgccgt ggttcaccgg cgacggccgg gagaccgtca cgctgtacca
    17161 gctcctcacc cacacctcgg ccgtgcccat gggcctcgat ccgctgcacg gcaccatggc
    17221 cgctcccctc gccctgcgcc gggagcggct gcgcacgatg acggtgccgc ccgacgcgcg
    17281 gccgggcacc cggatcgcgt acgcgccgtg gtgggcgtgg ttcctgatcg ccgaggtggt
    17341 ccgggccctc gacgggcgcg actacgagcg ctatctcacc gaggaggtcc tcgcgccctg
    17401 cggcatggac gccacccggg tcgtgctcag cccgcgggag taccgcgaca cggccgaccg
    17461 gctgccgctc atccacctcg ccggcggcgg cgcccccgtc caggccacgc actggtacgc
    17521 caccgaggcg tcctgcaccc gccccatccc gggactcaac atccgcggcc cgatgtccga
    17581 tctggcgctg ttcttcgagg ccctgatgaa cggcgggcag ggccggaagg gccgcgtgct
    17641 tcgcccccag acggtgctgg cgctcaccgc gcgccaccgg gtgggcctgg tcgacgcctt
    17701 cggcaacgcg gactgggggc tcggcttccg caacgagtcc caccacctgg gcgagatctg
    17761 cacggccttc agccgccacg cctcactgcg caccttcggc cactacggcc tgtggacctc
    17821 gtcggccttc gcggaccccg acgccgggct cgtcgtggca ctgcacctca acggcaagac
    17881 ctggcaggag gagcaccaga cacgcatgat cgcgatcggc gacgccctct acaaggatct
    17941 gggcctgacg tagaccacca attcagccgc cccccaatac ccccaacacc cctccccctg
    18001 aatggagttc cgcatgaccg accccgccgc acccgggccc ggcgcgcccg actcgccgca
    18061 cgccatcatc gatctcgccg tcgccttctg gaagtccaag gtcctgctga gtgccgtgga
    18121 gctgaaggtc ttcgccgccc tggccgaacg gcccgcgacg ggcacggagt tgcgcgcccg
    18181 cctcggcatc accgggcgcg gcggcgccga cttcctcgac gccctggtct cgatgggcct
    18241 cctggagcgg cgggacggcg tgtaccagaa cgccccgctc gccgaccggc acctggaccc
    18301 ggccaagccc gccaccgaca tctcgggcta cctggagttc ctcaacgcgg gcttcccctg
    18361 ctgggccggt ctcacggagg ggctgcgcac gggcgggcgg ctcgacttca cccgcgccct
    18421 cgccgcgtcc ggcaacaccg acggctccgg cgaagcgccg accgagcccg ccctggtcga
    18481 ggccgacgcc gacagcgaca ccttcggcga ggccttcgcc gcgccggacc aggtgagcgg
    18541 attcctgcgg gccatgaccg gctacagcat gggcgccaac cacgcgctcg ccgagacgca
    18601 cgactggcgg aacgtgcgca cggtggcgga cgtgggctgc gccgagggtt ccctcctcgc
    18661 ccagatcctc acccgccacg agcacgtgga gggcatcggc ttcgacctgc ccgtggtcga
    18721 ggagggattc acggcgcaca ccaagcagtt gggcatcgcc gaccgggcgc gcttcgaggg
    18781 cggcgacttc ttcaccggcc cgctgcccac ggccgacgtc ctcgtcatgg gacacgtcct
    18841 gcacgactgg gacctggaca tcaagaagat gctgatccgc aaggcgtacg aggccctgcc
    18901 cgcgggcggt tcgctgctca tctacgagtc cctgatcgac gacgaccgca gggaccgcac
    18961 caccggcctg ctgatcagtc tgaacgtgtc cctggtctcc gccgggggcc tcggctacac
    19021 gggcgccgac tgccggtcgt ggctggcgga atccggtttc gccgagacgt ccgtacgtca
    19081 tctcgacggc ccggagtacc tcgtcgtcgg caccaagagg gccgactagc gcgcacctgg
    19141 ccgccagttg acgaagcacc ggaggggcgg cgggtgccgg gccgggcgaa ctcccgtacc
    19201 gcaccggccg ccctcccttg agcgggagca cacacggact gatgaatcct ccgcacctgc
    19261 cgagcgggac ggcccaccag cacgggccgc ttcccgactt cctgcccacc gcggacggcg
    19321 cggccgaggt cgtgcccgtc gtcgcgccca ccggtgaccg catctggttg gtcaccgcct
    19381 tcgacctggg ccgctcggtc ctcaccgacg agcggttcag ccgcgccgcg gccgccgcac
    19441 ccgaggcccc ggccagccac ccgatgcgcc cggacccggc ggccctgacc agtctcgacc
    19501 cgccccagca cacccggctg cggcgcctgg tgaaccatcc gttcacgccc cgggccgtgg
    19561 ccggtctgga ggagggcatc cggcgccagg cccgccgact cctggccggg cgggaccgga
    19621 tcgacctcgt ctcgcagtac gcgatgccgc tgtccgccgc caccatctgc cgcgtcctcg
    19681 gcgtacccaa ggccgagcac acgcacttcg ccgacctcgc ggaccgcgcg ctcggcgtca
    19741 ccaccggcga cttcgcggag cagggcccgg cccgcgacgc gctgcgcgcc tacatcggcg
    19801 agttgatcag ccgggcccgc cgcgcccccg gcgagcacgt cctcggcgcc ctcgccacgg
    19861 cgtacgacga agacggcacg ctgagccacg acgagctgac ggcgctggtc gagctgctgc
    19921 tcaacgcggg ctacgagacg tccatcggcc aactgggcct ggctgtcgtc accttgctcg
    19981 aacaccccga acagtggcac cgcttggcgg cggcgccgca ccgcgaggcg gccgcggcgg
    20041 tggaggagct ccttcgccac acgccggtcg tgccgatgag cttcacacgc gtcgcccggc
    20101 aggacgtacg gctcggcacg gtcgtggtgc gggccgggga ggcgctcgtg gtgtcgctgc
    20161 tgcacgcgaa cttcgacgcg cgcgcccatc gcgaccccac ccgcctcgac atcacccgcc
    20221 gccccgcccg ccacttgacg ttcggccacg gcgcgcacat ctgcctggga gcccagctgg
    20281 cccgtaccca gctgcgcgtg gccctggcgg aactggccgc ggcggccccc ggcctcacgc
    20341 cccgcacccc tctgtccgcc ctgcgctggc ggcagcccga ggcggtcgtg cgcggcccgc
    20401 tcgccctgcc cgtacacctg accgccaccc gggcgggggc cgttcccggg tgacggtgcc
    20461 ccaggaggat tccgcaccac ggagagcaga atcactttgc ccgccccggg gacctgacgg
    20521 atcatggaaa cagcagagga gatcatccgg gtcaccgccg gaaacgactc acccggagca
    20581 gccgtggaag accagcagcg acaagacgcg tcagaggctc cgagagcgga cgtgggggcg
    20641 acgcggttct ccgtactcga tcgctcccgc acccgcgagg ggcacgaccc cacgcagccc
    20701 ctgcgggaca ccgtcgcgct cgcccaggag ctggaggcgc tcggctatca ccgcttctgg
    20761 gtgtccgagc accacggcgt gcccggagtc gcgggttccg cgccgacggt gctcgcggcg
    20821 gcggtcgccg gggccaccag gacgatccgg gtgggcacgg gcggggtgat gctgcccaac
    20881 caccaaccgc tggtggtggc cgagcagttc ggggtactgg aggcgctgtt cccggggcgg
    20941 atcgacatgg ggctcggccg ttcggtcggg ttcacggacg gggtgcgcaa ggcgctcggc
    21001 cgcgacaagc acgacgcgga cgacttcgcg gcgcacctgc acgaactgct cggctggttc
    21061 cggggcacct cggacacggg cgtgcacgcg cgtccggccg aggggctgag cgtcccgccg
    21121 tacgtcctcg ccatcggtga gggcgcccgg atcgcggcgg aggcggggct tccgatggtc
    21181 gtcggcgaca tccggagccg cgcgaagatg ctcgccgcca tcgagcgcta tcgcgccgcg
    21241 ttccggccct ccgcctggtc cgacgagccg tacgtggtca tctcgggctc catcgccgtc
    21301 gccggctccg aggaggcggc gcgccgactg ctcataccgg aggcctggtc cctggcgtac
    21361 tcgcgcacgc acggcacgtt cccgccgctg ccgtccgccg agagcgtcga ggagcgcgcc
    21421 gcgacggggg cgatgacgga caaggagcgg ggcttctacg agtcggggct gcgcggacac
    21481 ctccacggca ccgaggaccg ggtcgccgcc gagctggaga cgctgatcaa ggagagcggc
    21541 gcgcaggagg tcctggtgac cacgagcacg tacgaccgcg agggcctcag cgactccttc
    21601 cggcggctcg cgcggatcac cggactgcgg ggccccgggg ccccgtgacg ccacggaccg
    21661 atccgccccg gggtgcggaa cgggctccgg cctagaatcg tggggtttgc ccccgacctc
    21721 gtacggagcc cgcccatgca cagccgcccg gcccacgagc acgacccctt cgtacgggtc
    21781 cggggtgccc gcgagcacaa tctgcgcggg gtcgacgtgg acgtcccgcg tgacgtgctc
    21841 gccgtcttca ccggggtgtc cggctccggg aagtcctcgc tggccttcgg gacgatctac
    21901 gcggaggccc agcggcgcta cttcgagtcg gtcgccccgt acgcgcgccg tctgatccac
    21961 caggtgggcg cgccgaaggt cggggagatc accgggctgc cgcccgcggt gtcgctccag
    22021 cagcgccgcg ccgcgccgac ctcccgctcg tcggtgggca cggtcacgac gctctccaac
    22081 tcgctgcgaa tgctgttctc acgcgcgggc gactatccgg cgggcgccga gcggctggac
    22141 tccgacgcgt tctcgtcgaa cacggcggcc ggggcctgcc ccgagtgcca cggcctgggc
    22201 cgggtccacc gcaccaccga ggagctgctg gtccccgacc cctcgctgtc cgtccgcgag
    22261 ggtgcgatcg ccgcctggcc cggcgcctgg cagggcaaga acctgcggga cgtgctcgac
    22321 accctcggcc acgacgtgga ccggccgtgg cgggagctgc cgcaggccga ccgggactgg
    22381 atcctgttca ccgacgagca gccagtcgtg accgtgcacc cggtgcgcga ggcgggccgc
    22441 atccaacgcc cctatcaggg cacgtacatg agcgcccggc gctacgtcat gaagacgttc
    22501 tccgactcca agagccagac gctgcgcacg aaggccgagc gcttcctggc cagtgagccg
    22561 tgcccggcgt gcggcggcag caggctgcgc ccggaggcgc tcgcggtcac gttcgcgggc
    22621 cgcaccatcg cggatctttc ggcgctgccg ctcgccgagc tgaccaagca cctcgaagcg
    22681 gcggccggtt cgggcgcggg agcggccggg gcggagacgg ccgaggtgct gaccggcgac
    22741 ctcctggcgc ggatcggcac catcaccgaa ctgggcctcg gctacctctc ccccgaccgc
    22801 ccgaccccca ccctctcctc cggtgagctg caacgcctgc gcctggccac gcagttgcgc
    22861 tccggcctgt tcggcgtcgt gtacgtcctg gacgagccgt cggccggcct gcaccccgcc
    22921 gacacggagt cgctgctcac cgtcctggac cggctgaagg ccgcgggcaa ctcggtgttc
    22981 gtggtcgagc accacctgga cgtgatgcgg cacgcggact ggctcgtcga cgtgggcccg
    23041 cacgcgggcg agcacggcgg gcaggtgctg cacagcggcc cggtggcgga cctggaggcg
    23101 gtggcggagt ccgcgacggc ccgcttcctc ttcgaccgga ctccgatgac ggtacgtcag
    23161 gtacgggagc cgcacggctg gttgaaggtg gggccggtga cgcggcacaa cctgcggggc
    23221 gtgacagcgg agttcccgct cggcgcgttc accgccgtca cgggggtctc gggctcgggc
    23281 aagtccacgc tgatcggggc gctcgccgag gatccggcgg acctcgcggg cgtggaccgc
    23341 ctggtgtgcg tggaccagaa gccgatcggc cgcaccccac gctccaacct cgccacgtac
    23401 accggcctgt tcgacgtcgt ccgcaaggtc ttcgcggaga cggacgaggc gcgggcgcgc
    23461 ggctacggcg tgggccgctt ctcgttcaac gtgacgggcg ggcgctgcga gacgtgccag
    23521 ggcgagggct tcgtgagcgt ggaactgctg ttcctgccca gcacgtacgc cccctgcccc
    23581 gactgcggcg gcgcccgcta caaccctgag accctgcagg tcacgcatgc cgggctgacc
    23641 gtcgcggacg tcctcgacct caccgtcgag gccgccgccg acttcttcgc cgacaccccc
    23701 gccgcactgc gcagcctgcg cacgctcctc gacgtcggcc tcggctacct gcgcctcggg
    23761 cagcccgcga cggagctgtc cggcggcgag gcccagcgca tcaagctggc cagcgagctg
    23821 cagcgggtgc ggcgcggcca caccctgtac ctcctggacg agcccaccgc cgggctgcac
    23881 ccggcggacg tggaggtcct ggtggggcgg ctgcacgagc tggtcgacgg cggcaattcc
    23941 gtggtggtcg tcgagcacga catggctgtc gtggccggag cggactgggt ggtggatctc
    24001 gggccggagg gcggcgccga tggggggcgg gtggtcgcca cggggacacc cgccgacgcg
    24061 gcccgggcca ccgggagccg gacggggccg tatctggcgc gggcgttggg gcgctagccc
    24121 agcaccccgt accggcaccg gcacccgcgc ccgcaccggg aatcgcgtgg cgatgccagt
    24181 gtttcgaaat ccgcatcacc aggggccgag ggctccagga gcgggagggg cgcggtgtcc
    24241 acaccgacac cggggcggcc ggtgcgcggc tcggccaccg gaagcccgca catggccgcg
    24301 ctcgatctgt tcgggcggcg tgggagtctg cgcgtggtgt gggaactgcg cgaaggcgcc
    24361 tcggggttcc gtgccctgcg ccgacatgtc ctccagcgtg ctgcggcaac gcctcgtcga
    24421 gctgatcgag gcacgcctgg tgcaccagac gcccgacggc cactacgtcc tcaccgcact
    24481 gggccgacaa gcccacacgg cgctcacccc tctcgtggac tggtccgtca cctgggccgc
    24541 cgaactgacc gagccctccg ccgaatccgg caccgccgcc acggacgcac cggagattcc
    24601 ctagggccac gggccgtagg ccgcgcctcg cgaacccgtc cggcctgcgg cgatatctca
    24661 actcatatcg atccgcgcct tcttcactct tggacatgat ggtgtgtcac ctgcttcgct
    24721 gccgccgtga acaccaacgg gagatccatc cgacccggcc gccgggtcct gctgcgcggc
    24781 gccgccctcg gcgcggccgc gcccttgaca cccgccgccg cctccgccga cagcccggca
    24841 ccggccgcgc gctcgggcgg gggcagctcc gaggtcacgt accggtggct cggcacgtcc
    24901 ggctggcgcg tcgacctggg cgcggcgggc aagagggccg ggcggcaccg gacggtgctc
    24961 gtcgatccgt acgtcacgcg cttccccacc ggcctgttca gcggcgcctt cgaccccgcc
    25021 acccggctgc gcaccgacaa gccgctggtc cgcaggcacg cggggacacc ggaggtcatc
    25081 tgcgtgacgc acacccactg ggaccacctc aatgacgtgc ccttcctggc gcgggccacg
    25141 ggtgcccggg tcatcgggac cgagacgacg taccacgtgc tgcggtcctt cggcgtggac
    25201 gcggcgcagc tctgcgtcgt caagggcggt gaggtactcg acttcgacgg gtacgtggtg
    25261 gaggtcgcga gttcgcggca cagccgcaac gccgcgtact cctacttcgc gcccggcacc
    25321 ctgaacg
//
