LOCUS       NZ_BMVR01000019        25588 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence19, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000019
VERSION     NZ_BMVR01000019.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 113108)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 25588
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25588
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..25588
                     /SMILES="NC(CC1=CNc2c1cccc2)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25588
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[29:5588](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      30..5588
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            30..5588
                     /locus_tag="IE274_RS34855"
                     /old_locus_tag="GCM10010349_71170"
     CDS             30..5588
                     /EC_number="6.2.1.-"
                     /NRPS_PKS="Domain: Epimerization (39-352). E-value:
                     6.7e-127. Score: 416.2. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (366-528). E-value: 9e-39.
                     Score: 124.7. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_TIGR01720.1"
                     /NRPS_PKS="Domain: Condensation_DCL (538-841). E-value:
                     5.8e-110. Score: 359.0. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1004-1403). E-value:
                     7.5e-105. Score: 342.8. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1530-1598). E-value: 8.8e-28.
                     Score: 88.3. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1622-1836). E-value:
                     2.3e-34. Score: 111.8. Matches aSDomain:
                     nrpspksdomains_IE274_RS34855_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="IE274_RS34855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71170"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_229910005.1"
                     /sec_met_domain="Condensation (E-value: 1.5e-70, bitscore:
                     230.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-114, bitscore:
                     373.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.3e-16, bitscore:
                     50.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 2.1e-28, bitscore:
                     92.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTPRQIFECRTVAELAQVAVADGSDAGVVLEEFEGGGVGRLPV
                     LPVSRYLRELGGGFGRFSMSAVLDLPVGIDAVGLAVTLGAVFDRHDILRSRLVAGDEWS
                     LEVAERGSVDVAGLVHRVACDGEWGAPGWRELAEAELDEATGRLDPEGGVMGRFVWFDP
                     GADVPGRLLVVLHHLVVDGVSWRILLPDFAAAWEQVRSGEDPVLTDVGTSVRRWTHALQ
                     DEAVSEDRIAELPLWRGILETADPVIGSRPLDPAVDVASTAEYLSVRLPARVTEALLTS
                     VPTAFRGQVNDGLLAGLALAVAKWRQKRGISESSALIRLEGHGREEGVVPGADLSRTVG
                     WFTSMFPVRLDTNGAALDEAFAGGPAAGKVVKAVKEQLLAIPDKGVGYGLLRYLNPETA
                     AVLQGHSAGQIAFNYLGRFSAADMPENLRGLGWSEAPGVDDLVAAPDADMPLMSTLEIN
                     AHVSDTEQGPCLNARLGFPTGVLSREDVQELADLWCAALEGLTRHVARPGAGGLTPSDV
                     PLVSVDQRKLEVWEKKYPGLADVWPLTALQSGLLFHALFADAAYDAYHMQLVFHLSGPV
                     EPERMRVAGQSVLDRYANLRTAFVSDTAGEHVQLVVDDVQLPWHHTDLSDLSEEEREAA
                     YERILAEDDRLHFDLEKPPLVRMTLVTMGPDRAELVFTAHHVLLDGWSLPLLMQDLLRL
                     YGSDGDASVLPRTRGYRDFLTWLAQQDHDAAARAWAEELDGLDEPTLLCPDTTAEQADG
                     EESEGAEGLGQLEVPLSVETSRELERQAAELGVTLSTVVQAAWAVLLGRLTGRRDVVFG
                     TTVSGRPPAVPDIDTMVGLFINTLPVRVTCSPQDTFAQILTRLRDRQAVLLDHHHHGLA
                     RIQQDTGLSTLFDTMVGFQSYPIDRVGLTEANTTAGIAFTGITSLSGTHYPLGVIGSSE
                     PRLRVAMQYQRHTFDHAAVETIADRLAHILRSLAADPDVVVGTIEVLTPGERERLIGEF
                     NDTAAPLAEATIPELFAQRVSTGPDAVAVVDDDETLTYRELDVRSNRLARELLRRGVGP
                     ESVVAAALPRSAAMVVAWLAVLKAGGAHLPVDPGYPDERITYMLTDSGACLVLADATTA
                     EGLPEPNVPVFRLDDPQVAEALTGSDGTALKDAERGRPLSVAGTAYVIYTSGSTGRPKG
                     VAVTHSGVASMVDAHVDGLAITPDSRVLQLASPSFDVSVCELCMSLLSGAAVVLTDVER
                     LAPGIPLAKTIDERRVTHAMIPPHVLAALPPGSLSTVTSLATGGETIPPETVAEWSSGR
                     RMVTLYGLTETTVCVTMSTPLTADGKVAPIGRPTTNSRAYVLDTALRPVQVGVPGELYV
                     AGPGLARGYVGRPDVTADRFVACPFGGPGERMYRTGDVVVWTPDGDLVFQGRADHQVKI
                     RGFRIELGEVEAALLTHPGVAQAVVVTDGPPSARRLVAYVVPTEDGAEESVGAHPGNPS
                     DVPDGRTPRTLAAGLREHLRERLPEHMVPSAVVTIDEVPLTPNSKLDRRALPAPDHTGQ
                     LTGRAPRNSREELLCGLFAEVLGLDRVGADDDFFGLGGHSLLATQLVSRIRTVLGVETS
                     IRRVFQSPTVAELAVELAADSGAAESGDPFAAVLPIKTSGDKEPLWWIHPGSGLCWIYL
                     GFAGRLPADRPVYGIQAKGFDGVTQPPESIDAMVADYVEEILAVQPEGPFHLLGLSIGG
                     TLAHAMAAEFQRRGHEVGLLGLLDSVPSTFFERYEPPHATDIRAYFGEHLISAGNAGDH
                     EAFVDNAVSVIVGHTSMMDGFTSPTYRGDALFFNATAEGDGSYADLWRSHITGALREYD
                     IDSTHQDMYLPAPADEICRAVVRALDSDAEGGFGRES"
     aSDomain        147..1085
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_Epimerization.1"
                     /evalue="6.70E-127"
                     /label="IE274_RS34855_Epimerization.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="352"
                     /protein_start="39"
                     /score="416.2"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVVDG"
                     /tool="antismash"
                     /translation="VGRLPVLPVSRYLRELGGGFGRFSMSAVLDLPVGIDAVGLAVTLG
                     AVFDRHDILRSRLVAGDEWSLEVAERGSVDVAGLVHRVACDGEWGAPGWRELAEAELDE
                     ATGRLDPEGGVMGRFVWFDPGADVPGRLLVVLHHLVVDGVSWRILLPDFAAAWEQVRSG
                     EDPVLTDVGTSVRRWTHALQDEAVSEDRIAELPLWRGILETADPVIGSRPLDPAVDVAS
                     TAEYLSVRLPARVTEALLTSVPTAFRGQVNDGLLAGLALAVAKWRQKRGISESSALIRL
                     EGHGREEGVVPGADLSRTVGWFTSMFPVRLDT"
     aSModule        147..1613
                     /domains="nrpspksdomains_IE274_RS34855_Epimerization.1"
                     /domains="nrpspksdomains_IE274_RS34855_TIGR01720.1"
                     /incomplete
                     /locus_tags="IE274_RS34855"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       249..323
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0001"
                     /evalue="7.50E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS34855"
                     /protein_end="98"
                     /protein_start="73"
                     /score="11.8"
                     /tool="antismash"
                     /translation="IDAVGLAVTLGAVFDRHDILRSRLV"
     CDS_motif       540..605
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0002"
                     /evalue="6.60E-11"
                     /label="NRPS-E2"
                     /locus_tag="IE274_RS34855"
                     /protein_end="192"
                     /protein_start="170"
                     /score="34.4"
                     /tool="antismash"
                     /translation="LLVVLHHLVVDGVSWRILLPDF"
     CDS_motif       1029..1079
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0003"
                     /evalue="1.90E-09"
                     /label="NRPS-E5"
                     /locus_tag="IE274_RS34855"
                     /protein_end="350"
                     /protein_start="333"
                     /score="29.3"
                     /tool="antismash"
                     /translation="DLSRTVGWFTSMFPVRL"
     aSDomain        1128..1613
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_TIGR01720.1"
                     /evalue="9.00E-39"
                     /label="IE274_RS34855_TIGR01720.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="528"
                     /protein_start="366"
                     /score="124.7"
                     /tool="antismash"
                     /translation="AGKVVKAVKEQLLAIPDKGVGYGLLRYLNPETAAVLQGHSAGQIA
                     FNYLGRFSAADMPENLRGLGWSEAPGVDDLVAAPDADMPLMSTLEINAHVSDTEQGPCL
                     NARLGFPTGVLSREDVQELADLWCAALEGLTRHVARPGAGGLTPSDVPLVSVDQRKLE"
     CDS_motif       1149..1211
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0004"
                     /evalue="5.40E-11"
                     /label="NRPS-E6"
                     /locus_tag="IE274_RS34855"
                     /protein_end="394"
                     /protein_start="373"
                     /score="34.6"
                     /tool="antismash"
                     /translation="VKEQLLAIPDKGVGYGLLRYL"
     aSDomain        1644..2552
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="5.80E-110"
                     /label="IE274_RS34855_Condensation_DCL.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="841"
                     /protein_start="538"
                     /score="359.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHVLLDG"
                     /tool="antismash"
                     /translation="DVWPLTALQSGLLFHALFADAAYDAYHMQLVFHLSGPVEPERMRV
                     AGQSVLDRYANLRTAFVSDTAGEHVQLVVDDVQLPWHHTDLSDLSEEEREAAYERILAE
                     DDRLHFDLEKPPLVRMTLVTMGPDRAELVFTAHHVLLDGWSLPLLMQDLLRLYGSDGDA
                     SVLPRTRGYRDFLTWLAQQDHDAAARAWAEELDGLDEPTLLCPDTTAEQADGEESEGAE
                     GLGQLEVPLSVETSRELERQAAELGVTLSTVVQAAWAVLLGRLTGRRDVVFGTTVSGRP
                     PAVPDIDTMVGLFINTLPVRVT"
     aSModule        1644..5537
                     /complete
                     /domains="nrpspksdomains_IE274_RS34855_Condensation_DCL.1"
                     /domains="nrpspksdomains_IE274_RS34855_AMP-binding.1"
                     /domains="nrpspksdomains_IE274_RS34855_PCP.1"
                     /domains="nrpspksdomains_IE274_RS34855_Thioesterase.1"
                     /final_module
                     /locus_tags="IE274_RS34855"
                     /monomer_pairings="Trp -> Trp"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1713..1829
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0005"
                     /evalue="2.90E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="IE274_RS34855"
                     /protein_end="600"
                     /protein_start="561"
                     /score="45.3"
                     /tool="antismash"
                     /translation="DAYHMQLVFHLSGPVEPERMRVAGQSVLDRYANLRTAFV"
     CDS_motif       2052..2114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0006"
                     /evalue="2.10E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="IE274_RS34855"
                     /protein_end="695"
                     /protein_start="674"
                     /score="33.0"
                     /tool="antismash"
                     /translation="HHVLLDGWSLPLLMQDLLRLY"
     CDS_motif       2382..2435
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0007"
                     /evalue="6.80E-01"
                     /label="Cy4"
                     /locus_tag="IE274_RS34855"
                     /protein_end="802"
                     /protein_start="784"
                     /score="3.3"
                     /tool="antismash"
                     /translation="GVTLSTVVQAAWAVLLGR"
     CDS_motif       2451..2546
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0008"
                     /evalue="8.70E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="IE274_RS34855"
                     /protein_end="839"
                     /protein_start="807"
                     /score="63.1"
                     /tool="antismash"
                     /translation="DVVFGTTVSGRPPAVPDIDTMVGLFINTLPVR"
     CDS_motif       2598..2708
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0009"
                     /evalue="1.40E-09"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="IE274_RS34855"
                     /protein_end="893"
                     /protein_start="856"
                     /score="30.3"
                     /tool="antismash"
                     /translation="DRQAVLLDHHHHGLARIQQDTGLSTLFDTMVGFQSYP"
     aSDomain        3042..4238
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_AMP-binding.1"
                     /evalue="7.50E-105"
                     /label="IE274_RS34855_AMP-binding.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1403"
                     /protein_start="1004"
                     /score="342.8"
                     /specificity="substrate consensus: Trp"
                     /tool="antismash"
                     /translation="FAQRVSTGPDAVAVVDDDETLTYRELDVRSNRLARELLRRGVGPE
                     SVVAAALPRSAAMVVAWLAVLKAGGAHLPVDPGYPDERITYMLTDSGACLVLADATTAE
                     GLPEPNVPVFRLDDPQVAEALTGSDGTALKDAERGRPLSVAGTAYVIYTSGSTGRPKGV
                     AVTHSGVASMVDAHVDGLAITPDSRVLQLASPSFDVSVCELCMSLLSGAAVVLTDVERL
                     APGIPLAKTIDERRVTHAMIPPHVLAALPPGSLSTVTSLATGGETIPPETVAEWSSGRR
                     MVTLYGLTETTVCVTMSTPLTADGKVAPIGRPTTNSRAYVLDTALRPVQVGVPGELYVA
                     GPGLARGYVGRPDVTADRFVACPFGGPGERMYRTGDVVVWTPDGDLVFQGRADHQVKIR
                     "
     CDS_motif       3228..3269
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0010"
                     /evalue="6.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1080"
                     /protein_start="1066"
                     /score="13.1"
                     /tool="antismash"
                     /translation="LAVLKAGGAHLPVD"
     CDS_motif       3483..3542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0011"
                     /evalue="1.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1171"
                     /protein_start="1151"
                     /score="33.3"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVAVTH"
     CDS_motif       4032..4118
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0012"
                     /evalue="1.00E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1363"
                     /protein_start="1334"
                     /score="49.8"
                     /tool="antismash"
                     /translation="VGVPGELYVAGPGLARGYVGRPDVTADRF"
     CDS_motif       4203..4268
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0013"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1413"
                     /protein_start="1391"
                     /score="36.7"
                     /tool="antismash"
                     /translation="FQGRADHQVKIRGFRIELGEVE"
     aSDomain        4620..4823
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_PCP.1"
                     /evalue="8.80E-28"
                     /label="IE274_RS34855_PCP.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1598"
                     /protein_start="1530"
                     /score="88.3"
                     /tool="antismash"
                     /translation="EELLCGLFAEVLGLDRVGADDDFFGLGGHSLLATQLVSRIRTVLG
                     VETSIRRVFQSPTVAELAVELAA"
     CDS_motif       4626..4658
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0014"
                     /evalue="7.50E-02"
                     /label="Cy4"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1543"
                     /protein_start="1532"
                     /score="6.3"
                     /tool="antismash"
                     /translation="LLCGLFAEVLG"
     aSDomain        4896..5537
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS34855_Thioesterase.1"
                     /evalue="2.30E-34"
                     /label="IE274_RS34855_Thioesterase.1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1836"
                     /protein_start="1622"
                     /score="111.8"
                     /tool="antismash"
                     /translation="PLWWIHPGSGLCWIYLGFAGRLPADRPVYGIQAKGFDGVTQPPES
                     IDAMVADYVEEILAVQPEGPFHLLGLSIGGTLAHAMAAEFQRRGHEVGLLGLLDSVPST
                     FFERYEPPHATDIRAYFGEHLISAGNAGDHEAFVDNAVSVIVGHTSMMDGFTSPTYRGD
                     ALFFNATAEGDGSYADLWRSHITGALREYDIDSTHQDMYLPAPADEICRAV"
     CDS_motif       5076..5147
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS34855_0015"
                     /evalue="1.40E-10"
                     /label="NRPS-te1"
                     /locus_tag="IE274_RS34855"
                     /protein_end="1706"
                     /protein_start="1682"
                     /score="33.5"
                     /tool="antismash"
                     /translation="QPEGPFHLLGLSIGGTLAHAMAAE"
     gene            5863..7350
                     /locus_tag="IE274_RS34860"
                     /old_locus_tag="GCM10010349_71180"
     CDS             5863..7350
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016434201.1"
                     /locus_tag="IE274_RS34860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71180"
                     /product="amino acid permease"
                     /protein_id="WP_190119950.1"
                     /transl_table=11
                     /translation="MLDQGAPPQTRSPQGPVGLGTRLMRRKPVERLVAEGGQGEGGSLR
                     RTLGMWQLTMISIGATLGTGIFVVLGESVPKAGPAVTVSFVIAGLTALFSALSYAELAG
                     TIPVAGSSYSYAYATMGELVAWVCGWCLVLEYGVSVAAVAVGWGEYLNELLDGTIGVTI
                     PDALSAAPGEVDGAIINLPGLIVVLLAMVFLLGGAKESARANTIMVIVKIAALVLFCAV
                     GFTGFKSGNYADFMPLGVAGVSAAGASLFFSYIGFDAASTAGEEAKNPQRDLPRAIMLS
                     LIIVTALYVLVAAVAVGAWNWKDFEGSEASLTAIMNDVTGQNVWGTLLAAGAVISIASV
                     VLTVLYGQTRVLFAMSRDGLVPKKFAKVSGKTGTPRVNTVIVSLFCGALASVIPLGKLV
                     DATSIGTLFAFGLVNIAVVVLRRTRPDMNRTFRVPFGWLFPVLGFGFCAYNMFNLDSVT
                     WVVFGVWMAVGLVFYFLYGMRRSRLETAETPEVPAVK"
     gene            7376..7831
                     /locus_tag="IE274_RS34865"
                     /old_locus_tag="GCM10010349_71190"
     CDS             7376..7831
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645535.1"
                     /locus_tag="IE274_RS34865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71190"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_030360443.1"
                     /transl_table=11
                     /translation="MRLNDLDERIVHALAEDARRSYADIGQLVGLSAPAVKRRVDRLRA
                     TGAITGFTVRVDPAALGWETEGFIEIYCRRNTSPEAIQRGLERYPEIASASTVTGEADA
                     IVQVFAADMRHFERVLERIAGEPFVERTKSVLVLSPLMRRFSSGSPA"
     gene            complement(7962..8612)
                     /locus_tag="IE274_RS34870"
                     /old_locus_tag="GCM10010349_71200"
     CDS             complement(7962..8612)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645533.1"
                     /locus_tag="IE274_RS34870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71200"
                     /product="Repetin"
                     /protein_id="WP_190119951.1"
                     /transl_table=11
                     /translation="MSRIAFTPTRVAVLGAAVLLTAGAAGVAVASGEDVTHPGKRIGTQ
                     DAAHPAPAAKDAAAAKAKPREAAALTGSAKLFRKTTEDITFTFDAHLAARHNADPSKAT
                     GTFKFVHLEKPGGKGGWATGRIDCLLTGGKVASATGIITKTNIKEMNGSRVGFSVHDQG
                     KKDRLGYSWAAVGGPDGTKKLTKCNSAAPFEQVKKGTGDFHVQPWKLPYPDPR"
     gene            8946..9740
                     /locus_tag="IE274_RS34875"
                     /old_locus_tag="GCM10010349_71210"
     CDS             8946..9740
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117417.1"
                     /locus_tag="IE274_RS34875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71210"
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="WP_190120018.1"
                     /transl_table=11
                     /translation="MRTALLQSSGRPGSVAANLKVLDEAAERAAAAGARLLVTPEMFLT
                     GYAIGDDVPRLAEPADGDAADAVADIAVRHGLSVAYGYPERADADVFNAVQLIGADGTR
                     LANYRKTHLFGCFERDHFTPGDRAVVQADLDGLRIGLMICYDVEFPENVRAHALAGTDL
                     LLVPTAQMHPFQFVAESVVPVRAFENQMYVAYVNRVGPEGEFEFVGLSTLAGPDGIARA
                     RAGRGDELVFADADPAFLAASREANPYLSDRRPGLYGPLVQA"
     gene            9821..11515
                     /locus_tag="IE274_RS34880"
                     /old_locus_tag="GCM10010349_71220"
     CDS             9821..11515
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671499.1"
                     /locus_tag="IE274_RS34880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71220"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_190119952.1"
                     /transl_table=11
                     /translation="MTSTVPTAVQHTDAQPPITMFGPDFPYAYDDFLAHPAGLGQIPAT
                     EHGTEVAVIGGGLSGIVAAYELMKMGLKPVVYEADQIGGRLRTVGFEGCDADLTAEMGA
                     MRFPPSSTALQHYIDLVGLETKAFPNPLAESTPSTVVDLKGESHYATTVDDLPQVYRDV
                     MHAWNACLEEGADFSDMNRALRERDVPRIREIWAKLVEKLDNQTFYGFLCESEAFKSFR
                     HREIFGQVGFGTGGWDTDFPNSILEILRVVYTEADDHHRGIVGGSQQLPLRLWDREPQK
                     IVHWAPGTSLSSLHEGGEPKPAVTRLHRTAGNRVTVTDASGDIRTYQAAIFTAQSWLLL
                     SKIECDDSLFPIDHWTAMERTHYMESSKLFVPVDRPFWLDKDETTGRDVMSMTLTDRMT
                     RGTYLLDDGPDKPAVICLSYTWCDDSLKWLPLSANERMEVMLKSLGEIYPKVDIRKHII
                     GNPVTVSWENEPYFMGAFKANLPGHYRYQRRLFTHFMQEHLPADKRGIFLAGDDISWTA
                     GWAEGAVQTALNAVWGVMHQFGGATDATNPGPGDLYDEIAPVELPED"
     gene            complement(11522..12418)
                     /locus_tag="IE274_RS34885"
                     /old_locus_tag="GCM10010349_71230"
     CDS             complement(11522..12418)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645531.1"
                     /locus_tag="IE274_RS34885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71230"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_190119953.1"
                     /transl_table=11
                     /translation="MKHFTVGRDVPHVARFAEETGFDSLWVFERVLFPDPPTQGLWGIP
                     GRPWPGNYRSVADPLITLTLAAAVTERVRLGTSVLVAPLHGPFQLARALASLDAASGGR
                     VVAGLGTGWSLDEYAAAASAPYEQRGRFLDETLDVCRAVWGPDPVAYEGTWTKIAPSEV
                     GPKPARPIPVLLPANSPRAARRLVDRADGWMPGAAGAARLAEEWRRLTDLAAERGRTAP
                     IQSVLRANARYTPKPYDGPTRAPFRGSAEQIAEDLVAHAEVGVEEILIDLQSGVRDARE
                     LTDVAAAVHAAARAAGL"
     gene            complement(12530..13267)
                     /locus_tag="IE274_RS34890"
                     /old_locus_tag="GCM10010349_71240"
     CDS             complement(12530..13267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645530.1"
                     /locus_tag="IE274_RS34890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71240"
                     /product="DUF5995 family protein"
                     /protein_id="WP_268255603.1"
                     /transl_table=11
                     /translation="MAQSERIAERAHPVREDSGNGRRTGGGLDGVVARMRALDASWPRR
                     DGVAVFNRVYLAVTQEVSRSVAAGGFPDVTAAVTLDVRFAERYLRAVDAVAADRHPPAC
                     WRPLFQLRRHPGVRGLQFALAGINAHIGHDLALAVVDTSHALGCAPTDLEDEFDRVGDI
                     LVSLEERIREDLMPGPDLFQVADPITHLLGSWSLDRARDGAWSAARALWALRDFPGVAE
                     EMRARLDDTVGLVGRMLLTPLPD"
     gene            complement(13319..14734)
                     /locus_tag="IE274_RS34895"
                     /old_locus_tag="GCM10010349_71250"
     CDS             complement(13319..14734)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325044.1"
                     /locus_tag="IE274_RS34895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71250"
                     /product="uracil-xanthine permease family protein"
                     /protein_id="WP_190119954.1"
                     /transl_table=11
                     /translation="MDLGVRWRLHGDGRTPAPGAVVRPDERLSWPRTFGLGAQHVVAMF
                     GASFVAPVLMGLDPNLAIMMSGVATVIFLLATRGRVPSYLGCSLSFVGVAAVIRAQGGS
                     SATVTGAVFVVGAALFLVGLAVQKFGARIIHAAMPPIVTGAVVMLIGFNLAPVTASTYW
                     PQDQWTALFVMLFTGLAVVCLRGFWSRVAIFLGLIFGYALSWVLDSVFGKIHSQSGSGQ
                     ITDHWRLDLSAVGHADWIGLPSFHAPSFEWSAILVALPVVIALVAENAGHVKAVGEMTG
                     DDLDDKLGTAISADGAASMLSTAVGGPPNTTYSENIGVMAATRVYSTAAYWAAAAFALL
                     FGLCPKFGAVVAAIPGGVLGGITVILYGMIGLLGAQIWINAKVDLRNPLNLVPAAAGII
                     IGVGNVSLKFTDNFQLSGIALGTVVVITGYHVLRAFAPAHLKTQEPLLDSGTSTYDDGD
                     DTHKDSDAFPRSG"
     misc_feature    complement(14790..14810)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.74"
                     /tool="antismash"
     misc_feature    14819..14836
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.02"
                     /tool="antismash"
     misc_feature    complement(14892..14903)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     gene            14918..16225
                     /locus_tag="IE274_RS34900"
                     /old_locus_tag="GCM10010349_71260"
     CDS             14918..16225
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019059688.1"
                     /locus_tag="IE274_RS34900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71260"
                     /product="alginate lyase family protein"
                     /protein_id="WP_190119955.1"
                     /transl_table=11
                     /translation="MSARTRIGALFTATAAVAAVLVTALPATPAPASGPPPAAVPAAKP
                     EIPDTAVLDGTRLADAKRRLDRGDPELRRALGQLTTRADKWLGKGPWTVTDKPKPAPSG
                     DPHDYLSQAPYWWPTKPKTPDNPWGCPYEQRDGERNPEVDTGTDRRDVESVFDSTYELS
                     LAWYYTGDRKYAEHAAKILRTWFLDPATRMNPHLNHGQFIPCKYDGRAIGIIDFSQSYT
                     SVVDALAILGTGAPGWTTADRTKMRSWTKSFQKWLTDSEFGKQEAAAKNNHGTFYDMQL
                     AALAYANGDKALARKTVLNARAQRIDPQIAADGSQPQELTRTRSWHYSTFDLVAYTRLA
                     DIGRHVGVDLWKYRGPDGQSLFRAVDYLLPAATGAAKWPHPELEFLRYAASDVVRAAAD
                     AGSAAAKAAVPKLERPPGGDLWGLRPAADQLDSIAG"
     gene            complement(16368..17591)
                     /locus_tag="IE274_RS34905"
                     /old_locus_tag="GCM10010349_71270"
     CDS             complement(16368..17591)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005319965.1"
                     /locus_tag="IE274_RS34905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71270"
                     /product="MFS transporter"
                     /protein_id="WP_190119956.1"
                     /transl_table=11
                     /translation="MSAEQGHGVYDKRQLSRARLAVAVIFCVHGAVAGSFATRVPWIQD
                     HADLSAGLLGLALAFPAIGASVAMPLAGWVSHRFGARTALRGLLALWTLALTLPSLAPN
                     LVTLCAALFVYGATSGMADVAMNALGVEIEHRMDKSIMSGLHGMWSAGALIGSAGGTIA
                     AHLHVDARVHHFLAATVLTVLGLIACQGVLDLRSAPEEEAPPRFALPPKSALLIGAVGF
                     CAVFAEGASLDWSAVYLKDVLDSSAGLAAACTTGFTLTMAVARFAGDKVVDRFGAVRTV
                     RAGGVCAALGGLLVVTAQHAAMAMTGFALMGLGIAVVVPLAFAAAGRSGPNPSQAIAGV
                     ATITYTSSLVAPSAIGALADATSLVASFCLVTALACGLVAFAGVLRTAGRASVQAGSAE
                     SAPADRKS"
     gene            17849..19021
                     /locus_tag="IE274_RS34910"
                     /old_locus_tag="GCM10010349_71280"
     CDS             17849..19021
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988920.1"
                     /locus_tag="IE274_RS34910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71280"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_190119957.1"
                     /transl_table=11
                     /translation="MPASPSTARAINDRLALRLLQHEGPLTAGQLKQLTGLSRPSVADL
                     VERLQGSGLITVVGETGERRRGPNARLYGIVADRAHLAALDVRTESVSVVVADLLGAQL
                     AEATVPIGGGTGTGDAVERAVALVERTARAGGAGRLHTVGVGAPGLIDPATGDLRDSAG
                     LPTWHRRLVAALTERLPARVLVENETNLAARAEQRDGAAHDRDTFVLLWLGAGTGAAVV
                     LDGTLRRGASGGTGEIGFLPVPGTAGLPSATACDGGFHSLAGSAAVEELAADHGLKATP
                     EPSELPAAALVRHAVESCHTPFLDALADRVAIGAASVTAVLDPGCVVLGGELGRAGGEV
                     LAGRVGERVAAMSPLRTEVRASVLGGAAVLRGALLTARDAAQEELFAPGG"
     gene            complement(19191..20078)
                     /locus_tag="IE274_RS34915"
                     /old_locus_tag="GCM10010349_71290"
     CDS             complement(19191..20078)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019984001.1"
                     /locus_tag="IE274_RS34915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71290"
                     /product="RNA polymerase sigma-70 factor"
                     /protein_id="WP_190119958.1"
                     /transl_table=11
                     /translation="MPAPLADEFESHRSRLFGLAYRLLGSAQEAEDAVQDAFLRLSGAD
                     RAAIERLGAWLAKVVTNLCLNRLTSARARRETYVGAWLPEPVVTSGGALGPLESAEQRD
                     SVSMAFLVLLERLTPVERAVYVLREAFSYSHREIAGVLDVSEAYSRQLHRRAARAVAED
                     RARFESAPARHEELVGSFIAAARDGDLAGLERLLSEDVTWWGDGGGKATAARRPIVGRD
                     KVARFLIGGIETFGAGMEFSFAEVNGAPALVSRVDGALTGVATFEFAGGRVAGVRAVVN
                     PDKLGYVERQLSAA"
     gene            complement(20251..22575)
                     /locus_tag="IE274_RS34920"
                     /old_locus_tag="GCM10010349_71300"
     CDS             complement(20251..22575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645525.1"
                     /locus_tag="IE274_RS34920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71300"
                     /product="chitinase C-terminal domain-containing protein"
                     /protein_id="WP_190119959.1"
                     /transl_table=11
                     /translation="MPTPTRARATLLAAGAAVAGLLMSTLAATTSHAADNESCRPDGLY
                     KTPGVDVPYCSVYDADGREKMGADHQRRVIGYFTGWRTGKNGEPAYLASDIPWDKVTHL
                     NYAFAHIGSDNKISVGGDGEKNAATGMTWPGVAGAEMDPAYSYKGHFNLLNKFKKKHPN
                     VKTMVSVGGWAETGGYFGDDGKRVNSGGFYSMATNADGSVNQAGIETFADSTVAFIKKY
                     GFNGVDIDYEYPTTMKDAGNPLDWQLANGRRAGLVKGYAVLMKTLREKLDRAGAADGKH
                     YLLTVAAPSSGYLLRGMETFQVQKYLDYVNIMSYDLHGAWNEYVGPNASLYDDGKDAEL
                     AAAGVYGSQQYGGVGYLNTDWAYHYFRGSMPAGRINIGLPYYTRGFKNVQGGTDGLWGK
                     AASTDCPAGSGLTKCGDGAVGIDNLWHDKDDKGKESPAGSNPMWHAKNLEKGVVGDYVT
                     KYGFPADTKLSGTYARKYDSTLVAPWLWNAEKKVFLSTEDEQSVRAKADYVVDKGIGGT
                     MVWELAGDYKYNSAKGQYEIGDTLTTAMYDKFKSASPYGAKVAGKDLPAKAVDIGVEFG
                     DFKLGDSNYPITPKLKITNNTKTTLPGGTEFQFDYSTSAPANASDQSGFGTKVISTGHT
                     GNNVGGLKGDFHRVSLKLPAWQTLAPGASVDLSFNYYLPVSTPSNWTVNIGGTTYGLAG
                     DLARGTTVVEPGTGPGPTDPPDPTDPPGKCTAPTWSTSSEYGSGTTVSHKSHHWKSKWW
                     TKGEEPGTTGDWGVWQDLGAC"
     misc_feature    complement(22680..22695)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.25"
                     /tool="antismash"
     misc_feature    complement(22687..22702)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.03"
                     /tool="antismash"
     misc_feature    22837..22852
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     regulatory      22908..23038
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            23218..24513
                     /gene="ribD"
                     /locus_tag="IE274_RS39815"
                     /old_locus_tag="GCM10010349_71320"
     CDS             23218..24513
                     /EC_number="1.1.1.193"
                     /EC_number="3.5.4.26"
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008835 -
                     diaminohydroxyphosphoribosylaminopyrimidine deaminase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ribD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018551340.1"
                     /locus_tag="IE274_RS39815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71320"
                     /product="bifunctional
                     diaminohydroxyphosphoribosylaminopyrimidine
                     deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
                     RibD"
                     /protein_id="WP_229910006.1"
                     /transl_table=11
                     /translation="MATAAEAVAMRRAVALAARGLGFTSPNPVVGCVILDATGESVGEG
                     YHQRAGGPHAEVHALRAAADKARGGTAVVTLEPCNHTGRTGPCAQALLDAGIARVVYAV
                     GDPTPAATGGATTLRAAGVDVESGLLAEEAETVNAAWLTSVRTGRPHVTWKYAATLDGR
                     IAAADGTSRWISSAASRADVHRLRAECDAVVVGSGTQRADDPHLAVRGIDGVVQPLRVV
                     VDTHGTAVRPDARVLDDAAPTLVAVAEGVEPLPGVETVHLPYADEHADAENLPYVERAP
                     LAPRAASASSPSGRPGAGDDEDRLEHRFTASGGAYRAQRPAAPAAPTEPSTAARGLDVD
                     ALLAELHARGVRSVLLEGGPTLAGAFVAAGAVDRVIGYLAPTLLGAGPTALTGGGITTL
                     TEALRLDVRECVALGPDLRITATVAGPGTKEH"
     gene            24514..25167
                     /locus_tag="IE274_RS34935"
                     /old_locus_tag="GCM10010349_71330"
     CDS             24514..25167
                     /EC_number="2.5.1.9"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958057.1"
                     /locus_tag="IE274_RS34935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_71330"
                     /product="riboflavin synthase"
                     /protein_id="WP_190119960.1"
                     /transl_table=11
                     /translation="MFTGIVEELGEVTAVEDLGDASRFRLRGPVVTDGAKHGDSIAVNG
                     VCLTVVEHEGDEFTADVMAETLDRSSLGALAPGAKVNLERPTAVGARLGGHIVQGHVDG
                     TGAIVDRKPSDNWEIVKISLPDGLARYVVEKGSITVDGVSLTVVDAGPDYFTISLIPTT
                     LALTTLGVKQPGDPVNLEVDVIAKYVERLLGTGAVTPAQAAAGAAGAPAQEAAK"
ORIGIN
        1 aggtggtgtc gcgggcgcgg gtgctgggtg tggaggtgac gccgcggcag atcttcgagt
       61 gccggacggt ggccgagctg gcgcaggtgg cggtggcgga cggctcggat gcgggtgtgg
      121 tgttggagga gttcgagggg ggtggtgtgg gtcggctgcc ggtgttgccg gtgagccggt
      181 atctgcggga gttgggtggc gggttcggtc ggttctcgat gtcggcggtg ctggatttgc
      241 cggtggggat cgatgcggtg ggcctggcgg tgacgttggg tgcggtgttc gaccggcatg
      301 acattcttcg ctcgcggctg gtggctggtg atgagtggag tctggaggtt gcagagcggg
      361 gttcggtgga cgtggcgggc ctggtccatc gggtggcatg tgatggtgag tggggtgcgc
      421 cgggctggcg ggagctggcg gaggcggagc tggatgaggc caccgggcgg ttggatcccg
      481 agggtggggt gatgggccgg ttcgtgtggt tcgatccggg tgcggacgtt cctggtcggc
      541 tgctggtggt gttgcatcac ctggtggtgg acggggtgtc gtggcggatc ctgctgcccg
      601 atttcgccgc agcctgggag caggtgcgct ccggcgagga cccggtgctg actgacgtgg
      661 gtacgtcggt gcggcgctgg acgcacgccc ttcaggatga ggccgtcagc gaggaccgga
      721 tcgccgaact ccccctgtgg cgaggcatcc tggagacagc ggatcccgtc atcggctcgc
      781 gccccctcga ccccgccgtg gacgtggcat ccacagcgga gtacctgtcc gtgcgccttc
      841 cggcgcgggt gacggaggcg ttgctgacgt cggtgccgac ggcgttccgt ggccaggtga
      901 acgacggtct gctggccggg ctcgccctcg cggtggccaa gtggcggcag aagcgcggca
      961 tctcggagtc ctcggcgctg atccggctcg aagggcacgg gcgtgaggaa ggtgtcgtgc
     1021 cgggtgcgga tctgtcccgc acggtgggct ggttcaccag catgttcccc gtccgcctcg
     1081 acaccaacgg tgccgctctc gatgaggcgt tcgccggtgg acccgcggca gggaaggtgg
     1141 tgaaggcggt caaggagcag ctcctcgcca tccccgacaa gggcgtcggc tacggcctgc
     1201 tgcgctacct caatccggaa acggccgctg ttctacaggg gcactcggcc gggcagatcg
     1261 ccttcaacta cctgggtcgg ttctccgccg ccgacatgcc ggagaacctg cgcggcctcg
     1321 gctggagcga ggcccccggc gtcgacgacc tggtcgccgc gccggacgcg gacatgccgc
     1381 tgatgtcaac gctggagatc aatgcccacg tcagtgacac cgagcagggc ccgtgcctga
     1441 acgcccgcct gggcttcccc accggcgtgc tctcccgcga ggacgtgcag gagctggccg
     1501 atctctggtg cgcggcgctg gaaggcctca cccggcacgt ggcgcggccc ggcgccggtg
     1561 gtctgacgcc gtcggatgtg ccgctggtgt cggtggacca gcgcaagctg gaggtctggg
     1621 agaagaagta ccccggcctg gccgacgtgt ggccgctgac cgcactgcag tccgggctgc
     1681 tcttccacgc cctgttcgcg gacgctgcgt acgacgcgta ccacatgcag ttggtgttcc
     1741 acctctccgg accggtggaa cccgagcgga tgcgcgtggc ggggcaatcc gtcctggacc
     1801 gctacgccaa tctgcggacc gcgttcgtca gcgacaccgc cggtgaacac gtgcagctcg
     1861 tcgtagacga cgtccaactg ccctggcacc acaccgacct gagcgacctg tcggaggagg
     1921 agcgggaggc ggcgtacgag cggatcctcg ccgaggacga ccgcctccac ttcgacctgg
     1981 aaaagccgcc gttggtgcgg atgacgctgg tgaccatggg cccggaccgg gccgaactgg
     2041 tcttcaccgc ccaccacgtc ctcctggacg gctggtcgct gccgctgctg atgcaggatc
     2101 tgctgcggct gtacggctcc gacggtgacg cttcggtgct gccgcgtacg cgcggctacc
     2161 gggacttcct gacctggctg gcccagcagg accacgacgc ggccgcccgc gcctgggccg
     2221 aggaactcga cgggctcgac gaacccaccc tgctgtgccc ggacaccacg gccgagcagg
     2281 cggacggaga ggagagcgag ggcgccgagg ggctcggaca gctcgaagtg ccgctgtccg
     2341 tggagacgtc ccgcgaactg gagcggcagg ccgccgagtt gggcgtcacc ctgagcaccg
     2401 tcgtgcaggc ggcctgggcc gtgctgctcg gtcggctcac cgggcgccgg gacgtggtgt
     2461 tcggcaccac ggtgtccggc cgcccgcccg ccgtcccgga catcgacacc atggtcggcc
     2521 tgttcatcaa cacccttccc gtccgcgtga cctgctcccc ccaggacacc ttcgcccaga
     2581 tcctgacgcg gctccgggac cgccaggccg tcctgctcga ccaccaccac cacggcctcg
     2641 cgcggatcca gcaggacacc ggcctgagca ccctcttcga caccatggtc ggattccagt
     2701 cctatccgat cgaccgggtg ggcctcaccg aggcgaacac gaccgccggg atcgcgttca
     2761 ccggcatcac ctcgctcagc ggcacccact acccgctcgg cgtgatcggc agctccgaac
     2821 cccggctgcg cgtggccatg cagtaccagc gccacacctt cgaccacgcc gccgtggaga
     2881 ccatcgccga ccggctcgcg cacatcctgc gcagcctcgc ggccgacccg gacgtggtcg
     2941 tcgggacgat cgaggtgctc acaccgggcg aacgcgagcg gctcatcggc gagttcaacg
     3001 acacggcggc accgctggcc gaagccacca ttccggagct cttcgcacaa cgggtgtcga
     3061 cgggtccgga tgccgtcgcg gtcgtcgacg acgacgagac gctgacctac cgggagctcg
     3121 acgtccggtc gaaccggctg gcgcgcgagc tgttgcggcg cggagtggga ccggagtccg
     3181 tggtggcggc ggcgctgccg cgctcggcgg cgatggtggt ggcatggctg gccgtgctca
     3241 aggcgggcgg cgcgcatctg cccgtcgacc cgggctaccc ggacgagcgg atcacgtaca
     3301 tgctcacgga ctccggggcc tgcctggtcc tcgcggacgc gacgacggcc gagggccttc
     3361 ccgagccgaa cgtccccgtg ttccgcctgg acgatcccca ggtcgccgag gccctgaccg
     3421 gctccgacgg tacggcgctc aaggacgcgg agcgaggccg gccgctgtcg gtcgcgggaa
     3481 ccgcgtacgt catctacacc tcgggttcga cgggacggcc caagggagtc gcggtcaccc
     3541 actccggggt ggccagcatg gtcgacgcgc acgtcgacgg cctcgcgatc accccggaca
     3601 gccgggtgct gcagctcgcc tcgccgagct tcgacgtgtc ggtctgcgaa ctgtgcatgt
     3661 ccctgctctc gggcgccgcc gtggtcctca ccgacgtcga acgcctggcc cccgggatcc
     3721 ccctggccaa gacgatcgac gagcggcggg tgacccacgc gatgatcccg ccgcacgtgc
     3781 tcgcggcact cccgcccggc tcgctgtcca ccgtgacgtc cctggccacc ggcggcgaga
     3841 cgatcccgcc cgaaaccgtg gccgaatggt cgagcgggcg gcggatggtg accctctacg
     3901 ggctgacgga aaccaccgtg tgcgtcacca tgagcacgcc gttgacagcc gacggcaagg
     3961 tcgccccgat cgggcggccg accacgaact cccgggcgta cgtcctggac acggcgctgc
     4021 ggccggtgca ggtgggggtg cccggagagc tgtatgtggc cggtcccggc ctcgcgcgcg
     4081 gctacgtcgg ccgtccggac gtgacggccg accgattcgt ggcctgcccc ttcggcggcc
     4141 ccggcgaacg gatgtaccgg accggggacg tggtggtgtg gacgccggac ggcgacctgg
     4201 tgttccaggg gcgtgcggac caccaagtca agatccgcgg attccggatc gaactcggtg
     4261 aggtcgaggc ggcgctcctg acgcaccccg gcgtcgcgca ggccgtggtg gtcaccgacg
     4321 gtccgccgag cgcccggcgc ctggtggcgt acgtggtgcc gaccgaggac ggagccgagg
     4381 aatccgtcgg cgcgcacccg gggaacccca gtgacgttcc ggacggccgg acgccccgga
     4441 ccctcgccgc cgggctgcgc gagcatctgc gcgaacggct gccggaacac atggtgccgt
     4501 ccgcggtggt gaccatcgac gaggtgcccc tgacacccaa cagcaaactg gaccggcgcg
     4561 ccctcccggc gccggaccac accgggcagc tgaccggacg ggccccgcgg aactcgcgcg
     4621 aggagctcct gtgcggcctg ttcgccgagg tgctcggcct ggaccgggtc ggagccgacg
     4681 acgacttctt cggcctcggc ggacactcgc tcctcgccac ccaactggtc agccgcatcc
     4741 gcacggtgct cggcgtcgag acctcgatcc ggcgggtgtt ccagtcgccg accgtcgccg
     4801 aactggccgt cgagctggcg gcggacagcg gtgccgccga gtccggtgac ccgttcgcgg
     4861 ccgtactgcc gatcaagacg agcggggaca aggagccgct gtggtggatc caccccggca
     4921 gcgggctctg ctggatctac ctcggattcg ccggacggct gcccgcggac cgacccgtct
     4981 acggcatcca ggcgaagggc ttcgacgggg tgacacagcc gcccgagtcg atcgacgcca
     5041 tggtcgccga ctacgtcgag gagatcctcg cggtacagcc cgagggcccc ttccatctcc
     5101 tcgggctctc catcggcggc accctcgcgc acgccatggc cgccgagttc cagcggcgag
     5161 ggcacgaggt ggggctcctc ggcctcctcg acagcgttcc cagcaccttc ttcgaacgct
     5221 acgagccgcc ccacgccacc gacatccgcg cctacttcgg cgagcacctg atcagcgccg
     5281 gcaacgccgg tgaccacgag gcgttcgtgg acaacgcggt ctccgtcatc gtcggccaca
     5341 ccagcatgat ggacggcttc acgtcaccga cgtaccgcgg cgacgcgctg ttcttcaacg
     5401 cgacggccga aggagacggc tcgtacgcgg acctgtggcg cagtcacatc accggtgccc
     5461 tacgggagta cgacatcgac agcacgcacc aggacatgta cctgcccgca cccgccgacg
     5521 agatctgccg agcggtcgtc cgcgcgctcg acagcgacgc ggaagggggc ttcggcaggg
     5581 agagctgacc cggcgtaggc ggcgtggtgc gggtcactcc gcaccacgcc gcacgcaacg
     5641 gacgaaacgg acggcgcaac aaacacacgc tcatccccgt cgcacgcaac gatcttgtgc
     5701 cgatgcgcaa cgttgctgca ttacggttgg gaaccagcgc ctcgtagagt cgggcgctgt
     5761 acgtggcgtg gcggggactg cctgctcggt ggttcccgtt tttgcgtgtg gactgccgcg
     5821 gctccctgcc acctctaccg gcagcgatga aggagccagc gcgtgctcga ccagggcgca
     5881 cccccgcaga cccgaagccc ccagggcccg gtgggtctcg gcactcgact gatgcggcgc
     5941 aagccggtgg aacgcctggt cgcggagggc ggccagggcg agggtggctc gctgcggcgc
     6001 accctcggca tgtggcagct gacgatgatc agcatcggtg cgaccctcgg caccggcatc
     6061 ttcgtggtgc tgggcgagag cgtccccaag gccggtcccg ccgtgaccgt gtccttcgtg
     6121 atcgccggcc tcaccgccct cttctcggcg ctctcctacg ccgagctggc cggcaccatc
     6181 ccggtcgccg gatcctcgta ctcctacgca tacgcaacca tgggcgaact cgtcgcctgg
     6241 gtgtgcggct ggtgcctggt cctggagtac ggcgtgtcgg tcgcggccgt cgccgtcggc
     6301 tggggcgagt acctgaacga gctgctcgac ggcaccatcg gcgtcaccat cccggacgcg
     6361 ctgtccgcgg ctcccggtga ggtcgacggg gccatcatca acctgcccgg cctgatcgtg
     6421 gtgctgctcg ccatggtctt cctgctgggc ggcgccaagg agtccgcgcg cgccaacacg
     6481 atcatggtca tcgtgaagat cgcggccctc gtgctgttct gcgccgtcgg cttcaccggc
     6541 ttcaagtccg gcaactacgc cgacttcatg ccgctcggcg tcgccggggt cagcgccgcc
     6601 ggagcgagcc ttttcttctc ctacatcggc ttcgacgccg cctccaccgc cggcgaggag
     6661 gccaagaacc cgcagcgcga cctgccgcgc gcgatcatgc tctcgctgat catcgtcacc
     6721 gcgctgtacg tcctggtcgc cgccgtcgcc gtcggcgcct ggaactggaa ggacttcgag
     6781 ggctccgagg cgtcgctcac cgcgatcatg aacgacgtga ccggccagaa cgtctggggc
     6841 acgctgctcg ccgcgggcgc cgtcatctcc atcgccagcg tcgtcctgac cgtcctctac
     6901 ggccagaccc gcgtgctctt cgcgatgtcc cgcgacggcc tcgtgcccaa gaagttcgcc
     6961 aaggtcagcg gcaagaccgg cacgccccgc gtgaacaccg tcatcgtgtc gctgttctgc
     7021 ggcgcgctcg cctccgtgat cccgctcggc aagctcgtcg acgccaccag catcggcacg
     7081 ctcttcgcct tcggcctggt caacatcgcc gtggtcgtgc ttcgccgcac ccggcccgac
     7141 atgaaccgca cgttccgggt tcccttcggc tggctcttcc cggtgctcgg cttcggcttc
     7201 tgcgcgtaca acatgttcaa cctcgactcg gtcacctggg tcgtcttcgg tgtctggatg
     7261 gccgtcggcc tcgtgttcta cttcctgtac gggatgcgcc gctcccgtct ggagaccgcc
     7321 gagacccctg aggtccccgc ggtgaagtga cacgcagaga agtgaacgac cccctgtgcg
     7381 actgaacgat ctcgacgaac gcatcgtgca cgccctcgcc gaggacgccc gccgttccta
     7441 cgccgacatc ggccagctcg tcggactgtc cgcgcccgcc gtcaaacggc gcgtggaccg
     7501 gctgcgggcc accggagcga tcaccggctt caccgtccgg gtggacccgg ccgcgctcgg
     7561 ctgggagacc gaggggttca tcgagatcta ctgtcgccgg aacacctcgc cggaggcgat
     7621 tcaacggggg ctcgagcggt acccggagat cgcgtccgcc tccaccgtca ccggggaggc
     7681 ggacgcgatc gttcaggttt tcgcggcgga catgcggcac ttcgagcggg ttctcgaacg
     7741 gatcgcgggg gagccgttcg tggagcgcac caagtcggtg ctcgtcctct cgcccctgat
     7801 gcgccgcttc tcctcgggct cgcccgccta gccagggccc cgcacggggc acggggctga
     7861 acgaggccga ccccccgccc ggtccgtggc cgggcgggag gccggggtac acagcgaggc
     7921 acggaccgcc cgacccccgt acggacggcc cgcgcccctg atcaccgcgg gtcggggtac
     7981 ggaagcttcc acggctgcac gtggaagtcg cccgtaccct tcttgacctg ctcgaacggt
     8041 gcggcgctgt tgcacttcgt cagcttcttc gtgccgtcgg ggccgcccac cgcggcccag
     8101 ctgtagccga gccggtcctt cttgccctgg tcgtggacgc tgaagccgac gcggctgccg
     8161 ttcatctcct tgatgttggt cttcgtgatg atgccggtcg ccgacgccac cttcccgccg
     8221 gtcagcaggc agtcgatacg gcccgtggcc cagccgccct tgccacctgg cttctccagg
     8281 tgcacgaact tgaacgtgcc ggtcgccttg ctcgggtcgg cgttgtgccg ggcggccaga
     8341 tgcgcgtcga acgtgaaggt gatgtcctcc gtggtcttgc ggaacagctt cgccgagccg
     8401 gtgagcgcgg ccgcctcccg cggcttcgcc ttggccgcgg ccgcgtcctt cgcggcgggg
     8461 gcggggtggg cggcgtcctg cgtgccgatc cgcttgccgg ggtgcgtcac gtcctcgccg
     8521 gacgccacgg cgacgcccgc cgcgcccgcg gtgagcagga ccgcggcgcc aaggacggcg
     8581 acacgggtgg gggtgaaggc gatgcggctc acggggagcc ctccgttcgg tcaggccgtt
     8641 cgcccggcgt ttccgggtga gatcacgatc ccgtggcagg ggggtcggcc gcgtccggcc
     8701 gtgggctgca ctgcgcttcc gccgcacggg ggaggagccg cggcggggca tgcgcccgca
     8761 ggcggacacc tcgcccgccc ggcacgcaac gaatcgccgc cgcccccgtc ccacgcgcaa
     8821 caaatcgctc agaggggtgc aacggtcgca ccttgcccgg ccacggccgc ggaacgtacc
     8881 gtctttgcga acccctgacg cccgcccgtc tccctacgca cgcctcgagg tcagccatgt
     8941 cgccgctgcg cacagccctg ctccagagct cgggtcgccc cggctccgtc gccgccaacc
     9001 tcaaggtgct cgacgaggcc gcggagcggg ccgccgccgc cggtgcccgg ctgctcgtga
     9061 cgccggagat gttcctgacc gggtacgcga tcggcgacga cgtgccccgc ctcgccgagc
     9121 ccgccgacgg cgacgcggcg gacgcggtgg ccgacatcgc cgtacgccac ggcctctccg
     9181 tcgcctacgg ctacccggag cgcgccgacg ccgacgtctt caacgccgtc cagctcatcg
     9241 gcgcggacgg cacccggctc gcgaactacc gcaagaccca cctcttcggc tgcttcgagc
     9301 gcgaccactt cacgcccggc gaccgggccg tcgtccaggc cgacctcgac ggcctccgca
     9361 tcggcctgat gatctgctac gacgtggagt tcccggagaa cgtccgcgcg cacgccctcg
     9421 cgggcaccga cctcctgctc gtcccgaccg cgcagatgca cccgttccag ttcgtcgccg
     9481 agtccgtcgt gccggtgcgc gccttcgaga accagatgta cgtcgcgtac gtcaaccgcg
     9541 tcggccccga gggcgagttc gagttcgtcg gcctgtccac gctcgccggt cccgacggga
     9601 tcgcgcgggc gcgcgccgga cgcggcgacg agctggtgtt cgccgacgcc gaccccgcct
     9661 tcctcgccgc gtcccgcgag gccaacccct acctgagcga ccgccgcccc ggcctgtacg
     9721 gacccctcgt ccaggcctga ccgcaccggc cccgaccggc cgccgagggc gacgcctcgc
     9781 ccgcaccacc tttccgtacc gtgcaaggag tccgtacccc atgacgtcaa cggtgcccac
     9841 cgctgtccag cacaccgacg cgcagccgcc catcaccatg ttcgggccgg acttccccta
     9901 cgcgtacgac gacttcctcg cgcaccccgc gggcctcggc cagatacccg cgaccgagca
     9961 cggcaccgaa gtcgccgtca tcggcggcgg cctgtccggc atcgtggccg cgtacgagct
    10021 gatgaagatg ggcctcaagc ccgtcgtgta cgaggccgac cagatcggcg ggcggctgcg
    10081 caccgtcggc ttcgagggct gcgacgccga cctcaccgcc gagatgggcg cgatgcggtt
    10141 cccgccgtcc tccacggcgc tccagcacta catcgacctg gtgggcctgg agaccaaggc
    10201 gttccccaac cccctcgccg agtcgacccc ctccacggtc gtggacctca agggcgagtc
    10261 gcactacgcc accaccgtcg acgacctgcc gcaggtctac cgcgacgtga tgcacgcctg
    10321 gaacgcctgt ctggaggagg gtgccgactt ctccgacatg aaccgcgccc tgcgcgagcg
    10381 cgacgtgccg cgcatccggg agatctgggc gaagctcgtc gagaagctcg acaaccagac
    10441 cttctacggc ttcctctgcg agtccgaggc cttcaagtcc ttccggcacc gcgagatctt
    10501 cggtcaggtc ggcttcggca ccggcggctg ggacaccgac ttcccgaact ccatcctgga
    10561 gatcctgcgc gtcgtctaca ccgaggccga cgaccaccac cgcggcatcg tcggcggcag
    10621 ccagcagctt ccgctgcgcc tgtgggaccg cgagccgcag aagatcgtgc actgggcgcc
    10681 cggtacgtcg ctgagctcgc tgcacgaggg cggcgagccg aagcccgccg tgacgcgcct
    10741 gcaccgcacc gccggaaacc gcgtcaccgt cacggacgcg tcgggcgaca tccgcaccta
    10801 ccaggcggcc atcttcaccg cgcagtcctg gctgctgctc tcgaagatcg agtgcgacga
    10861 ctcgctcttc cccatcgacc actggacggc gatggagcgc acccactaca tggagtcctc
    10921 caagctcttc gtgcccgtgg accggccgtt ctggctggac aaggacgaga ccaccggtcg
    10981 tgacgtcatg tcgatgacgc tcaccgaccg catgacgcgc ggcacgtacc tgctcgacga
    11041 cgggccggac aagcccgccg tcatctgcct ctcctacacc tggtgtgacg acagcctgaa
    11101 gtggctgccg ctctcggcga acgagcgcat ggaggtcatg ctcaagtcgc tcggcgagat
    11161 ctacccgaag gtcgacatca ggaagcacat catcggcaac ccggtgaccg tgtcctggga
    11221 gaacgagccc tacttcatgg gcgccttcaa ggccaacctg cccggccact accgctacca
    11281 gcggcgcctg ttcacccact tcatgcagga gcacctgccc gcggacaagc gcggcatctt
    11341 cctcgcgggc gacgacatct cctggacggc cggctgggcc gagggcgccg tccagaccgc
    11401 gctcaacgcc gtgtggggcg tcatgcacca gttcggcggt gccaccgacg cgaccaaccc
    11461 cggtcccggc gacctctacg acgagatcgc gccggtggaa ctgccggagg actgagggcc
    11521 ctcagagacc ggccgcacgg gccgccgcgt gcaccgcggc ggccacgtcc gtcagctccc
    11581 gcgcgtcccg cacgcccgac tggaggtcga tgaggatctc ctccacgccg acctcggcgt
    11641 gcgccaccag gtcctcggcg atctgctcgg cgctgccccg gaagggggcg cgggtggggc
    11701 cgtcgtacgg cttcggggtg tagcgcgcgt tggcgcgcag gacgctctgg atcggagccg
    11761 tgcggccgcg ctcggccgcc aggtccgtga gccgccgcca ctcctcggcc aggcgcgcgg
    11821 cccccgccgc gcccggcatc cagccgtccg cgcggtccac gagcctgcgg gcggcgcgcg
    11881 ggctgttggc gggcagcagg accgggatcg ggcgggccgg tttcggcccc acctcggacg
    11941 gggcgatctt cgtccacgtc ccctcgtacg ccaccgggtc cgggccccac accgcccggc
    12001 acacgtcgag cgtctcgtcg aggaacctgc cgcgctgctc gtacggcgcc gacgccgccg
    12061 ccgcgtactc gtcgagggac cagcccgtgc cgaggcccgc gaccacgcgg ccgccgctcg
    12121 cggcgtccaa cgaggccagg gcgcgcgcca gttggaacgg tccgtgcagc ggggcgacca
    12181 ggacgctggt gccgaggcgc acccgctcgg tgacggcggc ggcgagcgtc agcgtgatca
    12241 gggggtcggc gaccgagcgg tagttccccg gccagggccg acccgggatg ccccacaggc
    12301 cctgggtcgg aggatcgggg aacaggacgc gttcgaagac ccagaggctg tcgaacccgg
    12361 tctcctcggc gaagcgcgcc acgtgcggga cgtcgcggcc gacggtgaag tgcttcatct
    12421 gcgggaggcc taggccgagt cggcaagagg gcacgacagc tcctgtgggt ccggcacggg
    12481 tcccgaaggg ctccgggacg ggtcccggtc acgctagccc ggttcgggat cagtccggca
    12541 gaggcgtgag cagcatccgt ccgacgagcc ccaccgtgtc gtccaggcgg gcccgcatct
    12601 cctccgccac gcccgggaag tcacgcagcg cccacagggc gcgcgccgcc gaccacgcgc
    12661 cgtcgcgggc gcggtccagg ctccaggagc ccaggaggtg ggtgatcggg tcggcgacct
    12721 ggaagaggtc ggggcccggc atcaggtcct cgcggatgcg ttcctccagc gagaccagga
    12781 tgtcgccgac gcggtcgaac tcgtcctcca gatcggtcgg cgcgcagccg agggcgtggc
    12841 tggtgtccac gacggcgagg gccaggtcgt ggccgatgtg ggcgttgatg cccgcgagcg
    12901 cgaactgcag gccgcgcacg ccgggatggc ggcggagctg gaacaggggc cgccagcacg
    12961 cgggcgggtg ccggtcggcc gccaccgcgt ccacggcccg cagatagcgc tcggcgaagc
    13021 ggacgtcgag ggtcaccgcc gccgtgacgt ccgggaaccc gcccgccgcg acgctccggc
    13081 tgacctcctg agtgaccgcc agatacacgc ggttgaagac ggcgacgccg tcgcggcgcg
    13141 gccaggaggc gtcgagggcg cgcatccgcg ccaccacgcc gtcgaggccg ccaccggtgc
    13201 ggcggccgtt tccgctgtcc tcgcgcacgg ggtgggcgcg ctcggcgatc cgctcggact
    13261 gggccatggg ggcaggttcc cagccccggc gcggcacgcg ggcacgccgg gcgcgggctt
    13321 acccagaacg agggaacgcg tccgagtcct tgtgcgtgtc gtccccgtcg tcgtacgtcg
    13381 acgtgcccga atccagcagc ggttcctggg tcttgaggtg cgcgggggcg aacgcccgca
    13441 gcacgtggta gccggtgatg accacgaccg tgccgagcgc gatgccgctg agctggaagt
    13501 tgtcggtgaa cttcagcgac acgttgccga cgccgatgat gatgcccgcg gcggccggga
    13561 ccaggttcag cggattgcgc agatccacct tggcgttgat ccagatctgc gcgccgagca
    13621 gcccgatcat gccgtacagg atgacggtga tgccgccgag cacgccgccg gggatcgccg
    13681 cgacgaccgc gccgaacttg gggcacaggc cgaagagcag ggcgaaggcg gccgccgccc
    13741 agtacgcggc ggtggagtag acgcgggtcg cggccatcac gccgatgttc tcggagtacg
    13801 tcgtgttggg cgggccgccg acggcggtgg agagcatgga cgcggcgccg tccgcggaga
    13861 tcgcggtgcc cagcttgtcg tccaggtcgt cgccggtcat ctcgccgacg gccttgacgt
    13921 gcccggcgtt ctccgcgacc agcgcgatca cgacgggcag ggcgacgagg atcgccgacc
    13981 actcgaagct cggcgcgtgg aaggacggca ggccgatcca gtcggcgtgc ccgaccgccg
    14041 acaggtccag gcgccagtgg tcggtgatct ggccggagcc gctctgcgag tggatcttgc
    14101 cgaagacgga gtcgagcacc cacgagagcg cgtacccgaa gatcaggccc aggaagatcg
    14161 ccacgcggga ccagaacccg cgcaggcaca ccacggcgag cccggtgaac agcatcacga
    14221 acagcgccgt ccactggtcc tgcggccagt aggtggaggc cgtcaccggc gccaggttga
    14281 agccgatcag catcaccacc gcgcccgtga cgatcggcgg catcgccgcg tggatgatcc
    14341 gcgcgccgaa cttctgcacc gcgagcccca ccaggaacag cgccgcgccg accacgaaca
    14401 ccgcgcccgt gaccgtcgcg ctcgacccgc cctgcgcccg gatcaccgcg gccacgccca
    14461 cgaacgacag ggagcagccg aggtagctgg gcacccggcc gcgcgtggcg agcaggaaga
    14521 tgaccgtcgc gacgcccgac atcatgatcg cgaggttcgg gtccaggccc atcaggaccg
    14581 gcgcgacgaa cgacgccccg aacatcgcca ccacgtgctg ggcgccgagc ccgaaggtcc
    14641 ggggccagga gagccgttca tcggggcgga cgacggctcc gggcgcgggg gtgcgcccgt
    14701 cgccgtgcag tctccagcgc acgccgagat ccatggtgag ttcgctttct gtgcgcgggg
    14761 gacgagccgt gtcgtcgcag ggacgagccg tgtcgtcatg tcgacgatca gcgtcgacat
    14821 gttagtgcga cgtaagggtg gctcctttcc ggcgcgcttc cgctacgttg gcatggccaa
    14881 gtcactgaac agcgttcacg tatctgatgg gagagtgatg agcgcccgta cccgcatagg
    14941 cgccctgttc accgccacgg ccgccgtcgc cgccgtactg gtgacggccc ttccggcgac
    15001 cccggccccg gcttcgggac cgcctccggc cgccgtgccc gccgcgaagc ccgagatccc
    15061 cgacaccgcc gtcctcgacg gcacgcgcct ggccgacgcc aagcggcggc tcgaccgggg
    15121 cgaccccgaa ctccgccggg ccctcggcca gttgacgacc cgcgcggaca agtggctcgg
    15181 caagggcccc tggacggtca ccgacaagcc gaagcccgcg ccgagcggcg acccccacga
    15241 ctacctgagc caggccccct actggtggcc gaccaagccg aagacccccg acaacccctg
    15301 gggctgcccg tacgagcagc gcgacggcga acgcaacccc gaggtcgaca cgggcaccga
    15361 ccgccgcgac gtggagagcg tcttcgactc gacctacgag ctgtccctcg cctggtacta
    15421 cacgggcgac aggaagtacg ccgagcacgc cgcgaagatc ctgcgcacct ggttcctcga
    15481 cccggcgacg cggatgaacc cgcacctgaa ccacgggcag ttcatcccct gcaagtacga
    15541 cggccgtgcc atcggcatca tcgacttctc gcagtcgtac acctccgtcg tcgacgccct
    15601 cgcgatactc ggcaccggcg cgccgggctg gacgacggcc gaccgcacga agatgcggtc
    15661 ctggaccaag agcttccaga agtggctgac ggacagcgag ttcggcaagc aggaggcagc
    15721 cgcgaagaac aaccacggca ccttctacga catgcagctc gccgccctcg cgtacgccaa
    15781 cggcgacaag gcgctggccc gcaagaccgt cctgaacgcg cgcgcccagc gcatcgaccc
    15841 ccagatcgcc gccgacggca gccagccgca ggagctgacc cgcacccgca gctggcacta
    15901 ctcgaccttc gacctggtgg cgtacacccg cctcgccgac atcggccggc acgtgggcgt
    15961 ggacctgtgg aagtaccgcg ggcccgacgg ccagagcctg ttcagggcgg tcgactacct
    16021 cctgcccgcc gcgacgggcg cagcgaagtg gccgcacccc gagctggagt tcctgcggta
    16081 cgcggcgagc gacgtcgtgc gcgccgccgc cgacgcgggc tcggccgcag cgaaggccgc
    16141 ggtgccgaag ctggagcggc cgccgggcgg ggatctgtgg gggctgcgtc cggcggccga
    16201 tcagctggac tcgatcgcgg gctgaggtgg gcggcccgga ccgcgttccc gggcgggggt
    16261 cgcgactccc gcccgggggc tggctgtcga gtgtgccggg ggccgcgggt ctcgccgggt
    16321 gtgcggggcc cgcgggcccg ccaggaggcg cggggcccgc gcgcccgtca ggacttgcgg
    16381 tccgccggtg ccgactccgc cgaaccggcc tgcaccgacg cgcgtccggc cgtccgcagc
    16441 acccccgcga acgccacgag cccgcacgcc agtgccgtga ccaggcagaa ggaggccacc
    16501 aggctggtcg cgtcggcgag agcgccgatc gccgacggtg cgaccaggct ggaggtgtac
    16561 gtgatggtgg cgacgcccgc gatggcctgg ctcgggttgg ggccgctgcg cccggccgcg
    16621 gcgaacgcca gtgggacgac gaccgcgatg ccgagaccca tgagcgcgaa cccggtcatg
    16681 gccatcgccg cgtgctgcgc cgtcaccacg agcagtccgc cgagcgcggc gcacaccccg
    16741 cccgcgcgca ccgtgcggac cgctccgaac cggtcgacca ctttgtcgcc cgcgaaccgc
    16801 gcgacggcca tcgtgagcgt gaagccggtg gtgcacgcgg cggccaggcc cgcggaggag
    16861 tcgagcacgt ccttgaggta caccgccgac cagtccaggc tcgcgccctc cgcgaacacc
    16921 gcgcagaagc cgaccgcgcc gatgagcagc gccgacttcg gcggcagcgc gaagcgcggc
    16981 ggtgcctcct cctccggcgc gctgcgcagg tcgagcacgc cctgacaggc gatcaggccg
    17041 agcacggtga gcacggtggc ggcgaggaag tggtgcacgc gggcgtcgac gtgcagatgg
    17101 gccgcgatcg tgccgcccgc cgagccgatc agggcgcccg cgctccacat gccgtgcagg
    17161 ccggacatga tggacttgtc catgcggtgc tcgatctcga cgccgagcgc gttcatggcg
    17221 acgtccgcca tgcccgacgt cgcgccgtac acgaacagcg ccgcgcagag cgtcacgagg
    17281 ttcggcgcga gcgacggcag cgtgagcgcg agcgtccaca gggcgagcag gccgcgcagc
    17341 gccgtccggg cgccgaagcg gtggctcacc cagcccgcca gcggcatcgc cacggaggcg
    17401 ccgatcgccg ggaaggcgag ggccaggccg agcaggcccg cgctgaggtc cgcgtggtcc
    17461 tggatccacg gcacccgggt ggcgaacgac ccggcgaccg ccccgtgcac gcagaagatg
    17521 acggcgacgg ccagccgtgc ccggctcaac tgccgtttgt catagacccc gtggccctgc
    17581 tccgcactca tccgctccac ccctccacgc tcccgttcgg aaccgccgca gtaaactatc
    17641 aggaaccctg cctgatagaa gagggtcagg gaaccgaata tctcgcgcgt ccggaaagcg
    17701 gcctctcctc cgtggagggt ggcttctccg cggcggaggg cggcctcagc ggagggcgcc
    17761 tctcctcggc ggagggtgcc ctcggcggag ggggtggtct ctccttcgtg gaggcggacc
    17821 ggcgtgagcg ctgtggaagg atcccgccat gcccgcatca ccgagcaccg ctcgggccat
    17881 caacgaccgg ctcgcgctgc gcctgctgca gcacgagggg cccttgacgg cgggacagtt
    17941 gaagcagctc accggcctgt cccggccctc cgtcgccgac ctcgtcgagc gtctgcaggg
    18001 ctccggtctg atcacggtcg tgggcgagac gggggagcgc cgccggggcc cgaacgcccg
    18061 cttgtacggc atcgtggccg accgggccca cctggccgcc ctggacgtgc gcaccgagag
    18121 tgtgtccgtg gtcgtggccg acctgctcgg cgcgcagctc gccgaggcca ccgtgccgat
    18181 cggcggcggc accgggaccg gcgacgccgt cgagcgggcc gtggccctcg tcgagcgcac
    18241 ggcccgtgcg ggcggcgcgg gccggctgca cacggtgggt gtcggcgcgc ccggcctcat
    18301 cgacccggcc accggcgacc tgcgcgactc ggcgggcctg cccacctggc accgccgcct
    18361 ggtcgcggcc ctcaccgaac ggctgcccgc gcgtgtcctg gtggagaacg agaccaacct
    18421 cgccgcccgc gccgagcagc gcgacggcgc cgcccacgac cgcgacacgt tcgtgctgct
    18481 ctggctcggt gcgggcaccg gcgcggccgt ggtcctcgac ggcaccctgc gtcgcggtgc
    18541 ctccggcggt accggcgaga tcggcttcct gcccgtcccc ggcaccgcgg ggctgccgtc
    18601 cgcgacggcc tgcgacggcg gcttccactc gctggccggt tcggcggcgg tcgaggaact
    18661 ggccgccgac cacggcctga aggcgacgcc cgagccgtcc gaactccccg ccgccgcact
    18721 ggtccggcac gccgtcgagt cctgccatac cccgttcctg gacgccctcg ccgaccgcgt
    18781 ggccatcggc gcggcgtccg tcacggccgt cctcgacccc gggtgcgtgg tgctcggggg
    18841 cgagttgggg cgcgcgggcg gcgaggtgct cgcggggcgg gtgggggagc gggtggccgc
    18901 catgtcgccg ctccggacgg aggtcagggc cagtgtgctg ggcggtgcgg cggtgctgcg
    18961 gggggcgctg ctgacggcga gggacgcggc gcaggaggag ttgttcgcgc ctggggggtg
    19021 agggggcggg gtcgggttgg ggggagccgt tctcgtcggg tcgggccgag cgtgcctcgg
    19081 atgccgtcgt ccggcgggac gtgtcgggcc gccgccccca cccgcagacg gcgctcccgc
    19141 cgggccggac agtgcccccg cccgcccgga cggcgccccc gcccgccctg tcaagcagcc
    19201 gacaactgcc gctccacgta ccccagcttg tccggattga ccacggctcg tacccccgcg
    19261 acccgcccgc ccgcgaactc gaacgtcgcc accccggtca gcgccccgtc cacccgcgac
    19321 accagcgcgg gcgcgccgtt gacctcggcg aacgagaact ccatcccggc gccgaaggtc
    19381 tcgatgccgc cgatcaggaa ccgtgccacc ttgtcgcggc cgacgatcgg ccgccgggcc
    19441 gcggtggcct tgccgccgcc gtcgccccac caggtgacgt cctccgagag cagccgttcc
    19501 aggcccgcga ggtcgccgtc gcgggccgcc gcgatgaacg accccacgag ctcctcgtgc
    19561 cgcgcgggcg ccgactcgaa gcgcgcgcgg tcctcggcga cggcccgcgc ggcccggcgg
    19621 tggagctggc gcgagtaagc ctcgctcacg tcgaggacac cggcgatctc ccggtggctg
    19681 tacgagaacg cctcccgcag cacgtacacc gcgcgctcca ccggcgtgag ccgctccagg
    19741 agcacgagga aggccatcga caccgagtcg cgctgctcgg ccgactccag cgggccgagc
    19801 gcgccgcccg aggtgacgac gggctccggc agccaggcgc ccacataggt ctcgcggcgg
    19861 gcgcgcgccg aggtgaggcg gttgaggcag aggttggtga cgaccttggc cagccaggcg
    19921 ccgaggcgtt cgatggcggc gcggtccgcg ccgctgaggc gcaggaaggc gtcctgcacg
    19981 gcgtcctcgg cctcctgcgc cgagcccagc aggcggtagg cgaggccgaa cagacgcgac
    20041 cggtgggact cgaactcgtc ggcgagcggc gcgggcatca cccctccagg ctgccagaac
    20101 gccgaccggc ccggccgctg ggggtggacc gggccggacc tgatgggagc ccggcggcga
    20161 ggcaagggca cgtcaacccg ccgccgggcg cttgtggggg gagcccgccg gggcaccgca
    20221 ggccgcagcc gagcggtcgc cgtccgacgg tcagcaggcg ccgaggtcct gccacacgcc
    20281 ccagtcaccg gtggtcccgg gctcctcgcc cttcgtccac cacttggact tccagtggtg
    20341 cgacttgtgg gacacggtcg tcccggagcc gtactcggac gacgtgctcc acgtgggcgc
    20401 ggtgcacttg ccgggcgggt cggtcgggtc gggcgggtcg gtgggcccgg ggccggtgcc
    20461 gggctcgacc acggtcgtgc cgcgcgccag gtcaccggcg agcccgtacg tcgtaccgcc
    20521 gatgttcacc gtccagttcg acggggtcga caccggcagg tagtagttga acgacaggtc
    20581 caccgacgcg ccgggggcca gcgtctgcca ggcgggcagc ttcagcgaga cgcggtggaa
    20641 gtcgcccttg agtccgccga cgttgtttcc ggtgtggccg gtgctgatca ccttcgtgcc
    20701 gaagccggac tggtcggacg cgttggcggg tgcggaggtc gagtagtcaa actggaactc
    20761 tgtgccgccc gggagggtcg ttttcgtgtt gttggtgatc ttcagcttgg gcgtgatcgg
    20821 gtagttggag tcgccgagct tgaagtcgcc gaactccacg ccgatgtcga cggccttggc
    20881 gggcaggtcc ttgcccgcga ccttcgcgcc gtacggggac gccgacttga acttgtcgta
    20941 catcgccgtg gtgagcgtgt cgccgatctc gtactgcccc ttggcggagt tgtacttgta
    21001 gtcaccggcg agctcccaga ccatggtgcc gccgatgccc ttgtcgacca cgtagtcggc
    21061 cttggcccgc accgactgct cgtcctcggt ggacaggaag accttcttct cggcgttcca
    21121 cagccagggc gcgacgagcg tcgagtcgta cttgcgcgcg taggtcccgc tgagcttggt
    21181 gtcggcgggg aagccgtact tggtgacgta gtccccgacg acacccttct ccaggttctt
    21241 ggcgtgccac atcgggttcg accccgcggg cgactccttg cccttgtcgt ccttgtcgtg
    21301 ccacaggttg tcgatgccga cggcgccgtc accgcacttg gtgagccccg acccggccgg
    21361 acagtcggtc gaggccgcct tgccccacag cccgtccgtg ccgccctgca cgttcttgaa
    21421 gccgcgggtg tagtacggca ggccgatgtt gatgcggccc gcgggcatcg aaccgcggaa
    21481 gtagtgatag gcccagtcgg tgttcaaata cccgacgccg ccgtactgct ggctgccgta
    21541 cacgccggcc gccgcgagtt cggcgtcctt cccgtcgtcg tacagggagg cgttcgggcc
    21601 gacgtattcg ttccaggcgc catggaggtc gtacgacatg atgttgacgt agtccaggta
    21661 cttctggacc tggaaggtct ccatgccgcg caggagatag ccggacgacg gcgcggccac
    21721 ggtcaggaga tagtgcttgc cgtcggcggc accggcccgg tccagcttct cgcgcagcgt
    21781 cttcatcagg acggcatagc ccttgaccag gcccgcgcgg cggccgttgg cgagctgcca
    21841 gtccagcgga ttgcccgcgt ccttcatcgt cgtcgggtat tcgtagtcga tgtcgacgcc
    21901 gttgaagccg tacttcttga tgaacgcgac ggtggagtcc gcgaaggtct cgatgcccgc
    21961 ctggttcacc gaaccgtccg cgttggtggc catcgagtag aacccgccgg aattcacgcg
    22021 cttgccgtcg tcgccgaagt atccgccggt ctcggcccaa ccgcccaccg agaccatggt
    22081 cttgacgttc gggtgcttct tcttgaactt attcagcaga ttgaaatgac ccttgtagga
    22141 gtacgcgggg tccatctccg cgcccgcgac gcccggccag gtcatgccgg tggcggcgtt
    22201 cttctcgccg tcaccgccca cggagatctt gttgtcgctc ccgatgtgcg cgaaggcgta
    22261 gttgaggtga gtgaccttgt cccaggggat gtcggacgcc agataggcgg gctcgccgtt
    22321 cttgccggtg cgccagccgg tgaagtagcc gatcacgcgg cgctggtggt cggcgcccat
    22381 cttctcgcgg ccgtcggcgt cgtagacgga gcagtagggg acgtcgacgc cgggggtctt
    22441 gtagaggccg tcaggacggc aggactcgtt gtcggcggcg tgcgaggtgg tcgcggcgag
    22501 ggtgctcatg agtagtccgg cgaccgctgc gccggctgcc aggagcgtgg ctctcgctcg
    22561 ggtgggggtg ggcacgtcgg ttcctcctgg ggaggctcgg tgtcgcacaa cgaacgggga
    22621 cggcggccca cggcgtgcgc acgccgggcg ggcctctcct cggagtgacg cagacgttaa
    22681 gaggactaga ccagtgcgtc aataggtacg gaccaatcct cttcggggtt cctgccaggt
    22741 gggtcgtggt gtgaaggggg gtgggaggcg cagtggaagg gggcggtgag ggcggggaag
    22801 agggggcggc ggggcgggcg ggcccgcccg ggcgcctgtg agccagccca caggatctcc
    22861 cctgcgcggc cctgaccagg cgtggcacac tggtctggta ccagaagcag cgcactccgg
    22921 ggtcggtgta attccgaacc ggcggttaca gtccgcgacc cggccgcctc cagcggtcgg
    22981 ttgaccaggt gaaactcctg gaccgacggt gaaagtccgg atgggaggca gtgcgcggcg
    23041 agcggacaca tgtgtcatgt gtgtcgcctc gtcgtcatgg ctcggttccg tcttgcggga
    23101 ccggtccctt tcgacgtccg gcgaccccgg cgacgatcca tgccggttgt tccgctcgtt
    23161 gagtgtcgtc gtcatcgaca gccccggagt ccgtgcccga agaggcagga ggacccggtg
    23221 gccaccgcag ccgaagcagt cgccatgcga cgcgccgtcg cgctcgccgc gcgcggactc
    23281 gggttcacga gccccaaccc cgtcgtcggc tgcgtcatcc tcgacgccac cggcgagagc
    23341 gtcggcgagg gctaccacca gcgcgcgggc ggaccccacg ccgaagtcca cgccctgcgc
    23401 gcggccgccg acaaggcccg cggcggcacc gccgtcgtca ccctcgaacc ctgcaaccac
    23461 accggccgca ccggcccttg cgcccaggcc ctcctcgacg ccgggatcgc ccgcgtcgtg
    23521 tacgccgtcg gcgaccccac ccccgccgcg accggcggcg ccaccaccct ccgcgcggcg
    23581 ggcgtcgacg tcgagtccgg cctgctcgcc gaggaggccg agacggtcaa cgccgcctgg
    23641 ctcacctcgg tccgcaccgg ccgcccccac gtcacctgga agtacgcggc cacgctcgac
    23701 ggccgcatcg ccgccgccga cggcaccagc cgctggatca gctccgccgc gtcccgcgcc
    23761 gacgtgcacc ggctgcgcgc cgagtgcgac gccgtcgtcg tcggctccgg cacccagcgc
    23821 gccgacgacc cgcacctcgc ggtgcgcggc atcgacggcg tcgtacagcc gctgcgggtc
    23881 gtcgtcgaca cccacggcac cgccgtgcgg ccggacgccc gggtcctgga cgacgcggca
    23941 cccacgctgg tggccgtcgc ggagggcgtg gagccgctgc ccggcgtgga gacggtgcac
    24001 ctgccgtacg cggacgagca cgcggacgcc gagaacctgc cgtacgtcga gcgcgccccc
    24061 ctcgcaccgc gcgcggccag cgcgtcatcg ccgtccgggc ggccgggcgc cggtgatgac
    24121 gaggaccgcc tcgaacaccg ctttaccgcc agcggcggcg cctaccgcgc acagcgcccg
    24181 gccgcccccg ccgcgccgac cgagccgtcg accgccgcgc gcggcctcga cgtcgacgcg
    24241 ctgctcgccg aactgcacgc ccgcggcgtg cggtccgtac tcctcgaagg cgggccgacg
    24301 ctcgccgggg ccttcgtggc cgccggtgcc gtcgaccgcg tcatcggcta tctcgcgccg
    24361 acgctgctcg gcgcgggccc caccgccctc accggcggcg gaatcaccac cctcaccgag
    24421 gcgttgcgcc tcgacgtgcg cgagtgcgtc gcgctcggac ccgatctgcg tatcaccgcg
    24481 accgtcgcgg gccccggaac gaaggagcac tgagtgttca ccggaatcgt cgaagagctg
    24541 ggcgaagtca ccgccgtgga ggacctgggc gacgcgtccc gcttccggct gcgcggcccc
    24601 gtcgtcaccg acggcgcgaa gcacggcgac tccatcgccg tcaacggggt gtgtctgacg
    24661 gtcgtcgagc acgagggcga cgagttcacc gccgacgtga tggccgagac cctcgaccgc
    24721 tccagcctcg gcgccctcgc ccccggcgcg aaggtcaacc tggagcgccc gaccgccgtc
    24781 ggcgcccgcc tcggcggaca catcgtgcag ggccacgtcg acggcaccgg cgccatcgtc
    24841 gaccgcaagc cgtccgacaa ctgggagatc gtcaagatct ccctgcccga cgggctcgcc
    24901 cgctacgtgg tcgagaaggg ctccatcacc gtcgacggcg tcagcctgac cgtcgtcgac
    24961 gccgggcccg actacttcac catcagcctg atccccacga cgctcgccct gaccacgctc
    25021 ggcgtcaagc agcccggcga cccggtcaac ctcgaggtcg acgtcatcgc caagtacgtg
    25081 gagaggctgc tcggcaccgg cgccgtgacg cccgcacagg ccgcggccgg tgcggccggg
    25141 gcacccgccc aggaggcagc gaagtgagca cgttcgactg gctgaactcc gaggcgttca
    25201 ccgccttcga ccagcacatc atgtggtccg acatggtcgg caacagcatc ggcctgatcg
    25261 ccctcgcgct cggctggcgc cgctccatct ggacctggcc cgcccagttc ctgtccggcg
    25321 tcgtcctcgt cgccgcgtac gcctccgcgc agctctccgg cggcgtcggc aagcagctcc
    25381 tcgtcatcgg cgtcgccgcg tggggctggc ggcagtggac gcggggcagc cgcaacgcgc
    25441 aggacggcac catcgccgtg cgcttcgcca cctggaagga gcgcggcttc ctgctcgcgg
    25501 gcaccgccgt cggcaccctc gccgtcggga cgctcttcac cgccctgccc gagctgtcct
    25561 ggaacccctg gccggacgcc tacatctt
//
