LOCUS       NZ_BMVR01000011        10366 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence11, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000011
VERSION     NZ_BMVR01000011.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 304518)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93375
            Orig. end                         :: 103741
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10366
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="1"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10366
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10366
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5366](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5366)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(19..33)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    complement(1289..1303)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.66"
                     /tool="antismash"
     misc_feature    1594..1609
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.71"
                     /tool="antismash"
     gene            complement(1673..2233)
                     /locus_tag="IE274_RS27000"
                     /old_locus_tag="GCM10010349_55330"
     CDS             complement(1673..2233)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018530640.1"
                     /locus_tag="IE274_RS27000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55330"
                     /product="chemotaxis protein CheB"
                     /protein_id="WP_198897786.1"
                     /transl_table=11
                     /translation="MAIASSAGGVHGAGVLLSGLGPHLRVPVFLVQHLDPRHRTVIAEV
                     LSRRTELPVKLAEHGERARPGTVHIAPPDRHLLVGPDGMLWLSDSALVHFVRPSADLLF
                     ESVAGAYGPRAIACVLTGTGCDGAMGVDAVKSRGGTVIAQDPETAEFSGMPQAAVGTGA
                     VDFVLPLEEIAAVVRGLVEDKRQ"
     gene            2485..3180
                     /locus_tag="IE274_RS27005"
                     /old_locus_tag="GCM10010349_55340"
     CDS             2485..3180
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384111.1"
                     /locus_tag="IE274_RS27005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55340"
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_190118499.1"
                     /transl_table=11
                     /translation="MGYGIDSPREAGTTRRNALGLAAGLLAGGALTATTATPASADDDE
                     WAAPGEEWIPEAEDWCDADFDEAFEADLAAAEATLPEEDSRGLGALERPTGRYTRPLRR
                     RYRVTSRYGVRGNWAAGHHTGIDLGVPHGTPVYAVTSGVVVLARWSGAYGKAVTVRMPD
                     KRYVLFAHLSRISVRQGQRIRTGARIGYSGATGRATGPHLHLEIRARRGYGSDINPVSY
                     LARRGVRLL"
     gene            complement(3210..3491)
                     /locus_tag="IE274_RS27010"
                     /old_locus_tag="GCM10010349_55350"
     CDS             complement(3210..3491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064389.1"
                     /locus_tag="IE274_RS27010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55350"
                     /product="hypothetical protein"
                     /protein_id="WP_190118500.1"
                     /transl_table=11
                     /translation="MTSARRLMAAVSLAAGAAALAAPAAHASTDAPAASKISVLDTIDD
                     LQTSGIPAERRHEVPTVASQLGGLNQLHQLHQLTDLAAPVTNAVPAVQ"
     misc_feature    3570..3584
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.96"
                     /tool="antismash"
     misc_feature    3618..3631
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.53"
                     /tool="antismash"
     gene            3710..3976
                     /locus_tag="IE274_RS27015"
                     /old_locus_tag="GCM10010349_55360"
     CDS             3710..3976
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449724.1"
                     /locus_tag="IE274_RS27015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55360"
                     /product="chaplin"
                     /protein_id="WP_190118501.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVTLGAGAVVLSGAALASADAGAQGKAVGSPGVLSGN
                     LLQVPVNVPVNVCGNTVDVVGLLNPAFGNKCANTGDMHGGYGK"
     gene            complement(4087..4956)
                     /locus_tag="IE274_RS27020"
                     /old_locus_tag="GCM10010349_55370"
     CDS             complement(4087..4956)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889041.1"
                     /locus_tag="IE274_RS27020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55370"
                     /product="tyrosinase family protein"
                     /protein_id="WP_190118502.1"
                     /transl_table=11
                     /translation="MVYTRRNQNTLSRAERRRFVDAVLRLKRRGEYDEFVRTHIDFYVS
                     DGDDRLRVAHMTPTFLPWHRRFLLDFERALRRMDDGVTVPYWDWTKDRSPAASLWSEDL
                     MGGNGRRSDRRVMTGPFARRNGWVVKEAVTDGDFLTRDLGRRSDPLELPTHRDVTWAMA
                     ETVYDVEPWDSTSRRGFRNRLEGWTEESGSARWRSHNRVHRWVGGHMLGGGSVNDPVFW
                     LNHAFVDLLWSRWQRLHPDSAPYLPAKPPTLGDAQYRRIVARREAMPPWRTTPQDMLSH
                     KTIYRYAE"
     misc_feature    complement(4885..4887)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5001..5366)
                     /locus_tag="IE274_RS27025"
                     /old_locus_tag="GCM10010349_55380"
     CDS             complement(5001..5366)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358346.1"
                     /locus_tag="IE274_RS27025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55380"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_268255587.1"
                     /sec_met_domain="melC (E-value: 1.7e-42, bitscore: 138.9,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRHLIAVAAAAALGAVGAFRGLREPRAEEGLPGPPGEPGFDET
                     YRGRRIQGEPATGAAVHGPGGWRVTVDGKPLGLMRRADGSYLSMLDHYQSYATPLAAAR
                     GAVDELGAHQTLSGRLH"
     gene            complement(5439..6101)
                     /locus_tag="IE274_RS27030"
                     /old_locus_tag="GCM10010349_55390"
     CDS             complement(5439..6101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644657.1"
                     /locus_tag="IE274_RS27030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55390"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_190118503.1"
                     /transl_table=11
                     /translation="MRAAATTGRVPVQASAARPAAVPRPDDSRAAGGGRGLALLLVLTA
                     AAGLLASWVITLDKFKLLADPDYVPGCSMNPVVSCGSIMKSEQAAVFGFPNPMLGLAAY
                     GVVLCAGVGLLAGARFPRWYWLTLNAGTVFGVVFCTWLQFQSLYRIHALCLWCCLAWAA
                     TLLMFWYVTSHNVRQGFLPAPTWLRTFMNEFTWVFPVLHSGVIGMLILTRWWDFWMS"
     gene            complement(6101..6604)
                     /locus_tag="IE274_RS27035"
                     /old_locus_tag="GCM10010349_55400"
     CDS             complement(6101..6604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065676.1"
                     /locus_tag="IE274_RS27035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55400"
                     /product="DUF5949 family protein"
                     /protein_id="WP_190118504.1"
                     /transl_table=11
                     /translation="MTSTSNEQRTFRVTDLGTLAVLAWSGEHPEDERDMAFLLAYSLGD
                     AEGGPEATAEAMRTLLRNENLPLGGPVLDGARTPSLPVSLLVEAEQAVVNMPHVKAQCV
                     VPPEWLAAVEQRGHAYFMITTVAWPEGKPGSPVSEEALRDFAGSEDTMLNAAHCLLPVR
                     RLRG"
     gene            complement(6879..7127)
                     /locus_tag="IE274_RS27040"
                     /old_locus_tag="GCM10010349_55410"
     CDS             complement(6879..7127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529519.1"
                     /locus_tag="IE274_RS27040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55410"
                     /product="chaplin"
                     /protein_id="WP_190118505.1"
                     /transl_table=11
                     /translation="MKNVKKAALVIAAAGLAAGAASGSAFASGDGASAEGAAVGSPGVA
                     SGNLGQVPVSVPVNVVGNTANLVGALNPAFGNSGTND"
     gene            complement(7233..7511)
                     /locus_tag="IE274_RS27045"
                     /old_locus_tag="GCM10010349_55420"
     CDS             complement(7233..7511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136064.1"
                     /locus_tag="IE274_RS27045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55420"
                     /product="hypothetical protein"
                     /protein_id="WP_190118506.1"
                     /transl_table=11
                     /translation="MKSLKAAAVLAGSMAIAGAAAPAFASDLTPTSLNGGLETVLGQSM
                     LDTKPVSTNMLDTENKDSVVNTVKDAAEGLNSGGGPTKMLGGLPLPK"
     misc_feature    7669..7682
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            complement(7768..8421)
                     /locus_tag="IE274_RS27050"
                     /old_locus_tag="GCM10010349_55430"
     CDS             complement(7768..8421)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="IE274_RS27050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55430"
                     /product="hypothetical protein"
                     /protein_id="WP_190118507.1"
                     /transl_table=11
                     /translation="MRALPVRRIATSFLCTALLLGTAGPVYAATHDDTAREAARTAPQV
                     PVPGADALLGQVKSLGDIGGVIKPVTDLLQAVLKADNGAVPAADLATLTSAVTTALDAA
                     KAAAPKGAALPETPQLPAAPQLPLGGAPAAQAPMDLKGDALAALQKSVEALVKAVTSAD
                     VAAIAKEVPAVLTGLVNFAVATLLGGGLPVPNLPGLPALPKLPVDGLPLPKLPV"
     gene            complement(8717..8956)
                     /locus_tag="IE274_RS27055"
                     /old_locus_tag="GCM10010349_55440"
     CDS             complement(8717..8956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="IE274_RS27055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55440"
                     /product="chaplin"
                     /protein_id="WP_190118508.1"
                     /transl_table=11
                     /translation="MSRTTKALALSAVAAAAVAGGAGVAAADSGAHGAATNSPGVISGN
                     AVQVPVHVPVNVCGNSINVIGLLNPAFGNTCVND"
     misc_feature    complement(9193..9207)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            9242..10348
                     /locus_tag="IE274_RS27060"
                     /old_locus_tag="GCM10010349_55450"
     CDS             9242..10348
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056483.1"
                     /locus_tag="IE274_RS27060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_55450"
                     /product="DUF3344 domain-containing protein"
                     /protein_id="WP_190118509.1"
                     /transl_table=11
                     /translation="MRHLLGPRRVLVVLLALTGCLALPGTGAAAPGTGAAAPGGEKPRI
                     AFAQRYHAVQHGGIVRAANSSITCRRPVSRAVAPCADVRRGGPGANHDFEMFYTDIDRD
                     PNTYNSSAGEVRLPAGSRVSYARLYWGGNLRVGEQKPPKDNGRVLIAEPGGSYRAVLAD
                     TLTGHRVAGGADAFQASADVTSLVRGSGAGLYTVAQVNVAMGHSKAGAWGGWTLVVAYE
                     NAALPKRSLALWDGFDSFGVPGRRHTVRMRGVPVAPGARGTVGVVAYDGDRGVRGDAVH
                     VSAGRGRPVPLSDHANPAADVLNSTVSEPGRPARRSPAYANTLGYDSDVLRLPERPRGQ
                     RGDLTVRVSARRDAAWTGVLFAAVDVQR"
ORIGIN
        1 agcccgaagt cgagtccgta gaacggctcg tccatgacct cgtccgggcg cagtccccac
       61 agctcgctcg cgccccggtt ccagctcttg accctcatct cggcgtccag gaccaccaca
      121 cccgccgcga cgctgctcat cacgccctcc aggaaggcgc gggcctcgtc cagctcctcc
      181 gagcggatgc gcatctcgtc gttcatggtc tccagttcct cgttcccgga ctggagttcc
      241 tcgttcgtgg tctccagctc ctcgttcgtg gactggagtt cctcgttcgt cgtctccagt
      301 tcctcgatgc tggactggag ttcctcgttg gtggtctcca gttcctcatt ggtggactgg
      361 agctcctcgt aggccgtctc cagatcttcg cgtacgcgct tgatctcggc cttgagctgg
      421 gtggacaccg tgacgtcgga gaacgtgatg atggtggccg cgggcagccc gtcggtgccg
      481 gagagcggct ggatcacgat gtcgttgtac tggatgtcgt cccccgtccg ccgcgcgacc
      541 cggttgatgc gcagcgtcct gcgttcgtgc gtggcctgct cgatcagcga gcgcagctcg
      601 accggccggt aggagatctc caggtcctgg aagagccgcc cgcagtcgtt cgaggtgagc
      661 ccgaactgca cccgggcgtg cgcgttgacc agcacgaccg tgccgtccgc gtcgacagcg
      721 acggccggta ccggaatggc gtcgagcagc aggtcgcgca gctgccggtt gcgggccacc
      781 gagcgctgtt ccaggccgac gccggacctg atcttcaggg gcgcgggctg gtagggcggt
      841 cccgagtcgc cgggcctgcg tctgaagacg cgctggcgca tgctgacgac ctcgaagcgc
      901 tcggcgtcgt tcaggagcat ctcggccttg ccgaggaaca ggaacccgcg ctcgcgcagc
      961 gcgaagtgaa agcggtcgac gatctgcgac tgcgcctcga cgttgaagta catcagggtg
     1021 ttgcggcaga cgagcagatc gagccgggag atgggggcgt cgcgggtcac gtcgtgccgt
     1081 ccgaagatca cccggcgccg caggtcgggc cggaagccgt actgtgcgcc gttctgctcg
     1141 aagtacttct cgcgcagctc ggcgggcagg gcctccaggt ccttggcggt gtagagcgcg
     1201 gagcgggcct cgcgcagcgc ctcctcgtcg acgtccgtgc cgtagatctt gacgcggttg
     1261 acgcactcct cgatgccgag cgcctcggcg aacatgatgg ccagggagta tgcctcctcg
     1321 ccgctcgaac agccggcgct ccacacccgc acctcctcgt cggagtcgag cccggcgagc
     1381 agctccggca ccacctcgcg ctgcagaaac gtccatgcgt cggggtcacg gaagatcgag
     1441 gtgacattga tcaggatggt gttgaagagc gcgccgaact cgtcggcgct ggtctccagg
     1501 cggtcgcggt agtccgcgta cgactgcacg tcgacatcgg acatccgctt gcggatgcgg
     1561 cgtccgagcg aggaacgctt gtacccggtg aagtcgaatc cccgtgcgtc ccgcagaaag
     1621 ccgagaaggt cctcaagttc ctcgtccgtc tcggtgtcct gcgtaccggc catcactgcc
     1681 tcttgtcctc gacgagtccg cgcacgaccg cggcgatctc ctccagaggt agcacgaagt
     1741 cgacggctcc cgtgcccacg gccgcctgcg gcataccgct gaattcagcc gtctccggat
     1801 cttgggcgat caccgtgccg ccgcgcgact tcaccgcgtc gacgcccatc gcgccgtcgc
     1861 agcccgtccc ggtcaggaca caggcgatgg cccggggccc gtacgccccc gccaccgact
     1921 cgaagagcag gtcggccgag ggccgcacga agtggaccag ggcgctgtcc gacagccaga
     1981 gcatgccgtc cgggcccacg aggaggtgcc ggtcgggtgg cgcgatgtga acggtgccgg
     2041 gccgggcccg ctcaccgtgc tccgcgagct tcaccggcag ctcggtgcgg cgggagagca
     2101 cctcggcgat caccgtgcgg tggcgcgggt cgaggtgctg gacgaggaac acgggcacgc
     2161 gcagatgggg gccgaggccg ctgagcagca ctccggcgcc gtgcacacct ccggccgacg
     2221 acgcgatggc caccaccccg taggaggtgt ccgcgtctac gtcgtctacg tccgtgccgg
     2281 cgttcgtcga ctcctgaggc gtcacactgt cgagcctagc gcgggtggcg gccgcggtct
     2341 cgggcccgga cacgaacagc ctgttcggaa gggtagaaga gggcccgccc gcggcgcggg
     2401 cggcgccccc gcgctccccg gcccttacgc caggcggcgc aatcgaccgt gcgcgccgct
     2461 gccgtcacgc gtgtccttgc aggtatgggc tatggcatag acagcccgcg cgaagcgggc
     2521 accacacgac ggaacgcgct cggcctggcc gcgggactgc tggccggcgg cgcgctgact
     2581 gcgaccacgg cgacccccgc gtctgcggac gacgacgaat gggccgcgcc gggggaggaa
     2641 tggatccccg aggccgagga ctggtgcgac gcggacttcg acgaggcgtt cgaggccgac
     2701 ctcgccgccg cggaggccac gctccccgaa gaggacagcc ggggcctcgg cgccctggag
     2761 aggcccacgg gcaggtacac ccggccactg cgccgccgct accgcgtcac ctcgcgctac
     2821 ggcgtgcgcg gcaactgggc cgccgggcac cacaccggca tcgacctggg ggtgccgcac
     2881 ggcacccccg tgtacgcggt gaccagcggt gtcgtggtgc tcgcccgctg gtcgggggcg
     2941 tacggcaagg cggtgaccgt acggatgccg gacaagcgct atgtgctgtt cgcgcacctc
     3001 tcgcggatct cggtgcgcca gggccagcgc atccgcaccg gcgcccgcat cggctacagc
     3061 ggcgccaccg gacgtgccac gggcccgcac ctccacttgg agatacgggc ccggcgcggc
     3121 tacggctcgg acatcaaccc cgtctcctac ctggccaggc gaggggtacg gctgctgtag
     3181 gcggcttgtc cttgagcgtc ggccgcgggc tactggacgg cgggcaccgc gttggtcacg
     3241 ggcgccgcca ggtcggtgag ctggtgcagt tggtgcagtt ggttcagacc gccgagctgg
     3301 ctggcgaccg tgggcacctc gtgccggcgc tcggccggga tgccggaggt ctgcaggtcg
     3361 tcgatcgtgt ccaggacgga gatcttggac gcggccggcg cgtcggtgga cgcgtgcgcg
     3421 gcgggcgcgg ccagcgccgc ggcaccggcg gcgagggaga cggcggccat gagtcggcgt
     3481 gctgatgtca tgccctcaca aacgcccggg ggcggtgaag gatacggctc gctgaccgct
     3541 gtcactcagg aagcgcaccc cgcccggggt gttttccgga atttctcggc ccctcgtacg
     3601 acacgaatac gcaaagcgtc acccggcgtg acttcgtgtc aacaacgtgc gttagaggaa
     3661 ctgcggccgt ccctatgcgg ccgtattttc ccagtcaaag gagaacgtga tgtctcgcat
     3721 cgcgaaggca gccgccgtca cgctcggcgc gggtgccgtc gtactcagcg gtgccgcgct
     3781 tgcctcggcg gacgcgggcg cgcagggcaa ggccgtcggc tcccccggtg tgctctcggg
     3841 caacctgctc caggtccccg tcaacgttcc ggtgaacgtc tgcggcaaca ccgtcgacgt
     3901 cgtcggcctg ctgaaccccg cgttcggcaa caagtgcgcc aacaccggcg acatgcacgg
     3961 cggctacggc aagtgacgcc gaggcgaggc ccccggcatc ggccgggggc ctcgccgtgt
     4021 gcgggggcca cccgcgcggg ccgcgccgcc ccgtcctcgc ggagctgctc ggcgtaccgg
     4081 gcggcgctac tcggcgtacc ggtagatcgt cttgtggctg agcatgtcct gcggcgtcgt
     4141 ccgccacggc ggcatcgcct cgcggcgcgc gacgatgcgc cggtactgcg cgtcgccgag
     4201 ggtgggcggc ttcgccggga ggtacggggc ggagtcgggg tgcagccgct gccaccggct
     4261 ccacagcagg tcgacgaagg cgtggttcag ccagaagacc gggtcgttga cggagccgcc
     4321 gccgagcatg tgcccgccga cccagcggtg cacccggttg tggctgcgcc agcgcgcgct
     4381 gccgctctcc tccgtccagc cctccagtcg gttgcggaag ccccgccgtg acgtggagtc
     4441 ccagggctcg acgtcgtaca ccgtctccgc catcgcccac gtcacgtccc ggtgggtcgg
     4501 cagctccagc gggtcggagc ggcgcccgag gtcgcgggtg aggaagtccc cgtcggtgac
     4561 ggcctccttg acgacccagc cgttgcggcg ggcgaaagga ccggtcatga cccgccggtc
     4621 gctgcgccgc ccgttgccgc ccatcaggtc ctcgctccac agggacgcgg ccgggctgcg
     4681 gtccttcgtc cagtcccagt acggcaccgt gacgccgtcg tccatgcggc gcagggcccg
     4741 ctcgaagtcg agcaggaagc ggcggtgcca gggcaggaag gtgggcgtca tatgggcgac
     4801 gcgcagccgg tcgtcgccgt cggagacgta gaagtcgatg tgcgtgcgga cgaactcgtc
     4861 gtactcgccg cgccgtttga ggcgtaacac ggcgtcgacg aaccggcgtc gctcggcccg
     4921 gctgagggtg ttctggttcc tgcgcgtata gaccatggca gtcggtgtcc gtccgttctc
     4981 cgttccggtg tgggcggggc tcagtggagt cggccgctca gggtctggtg cgcgccgagt
     5041 tcgtcgacgg cgccgcgggc ggccgccagc ggggtcgcgt acgactggta gtggtccaac
     5101 atgctcagat agctgccgtc ggcgcgccgc atcaggccga gcggcttccc gtcgacggtg
     5161 acccgccagc cgccgggacc gtgcacggcc gcaccggtcg cgggctcgcc ctggatgcgc
     5221 cgcccgcggt acgtctcgtc gaagccgggc tcgcccggcg gccccggcag cccttcctcc
     5281 gcgcgcggtt cgcgcagccc ccggaaggcg ccgacggcac ccagggcggc cgcggccgcg
     5341 acggcgatca gatgacggcg cgtcaaccgg tggactctga ttgcgggcga caccgcgatg
     5401 ttctcctccc gagcgaggac ggttacgacg aggcgcgatc agctcatcca gaaatcccac
     5461 caacgcgtga ggatcaacat gccgatgaca cccgaatgca gcaccgggaa tacccaggtg
     5521 aactcattca tgaacgtacg cagccacgtg ggtgcgggca gaaatccctg gcggacattg
     5581 tgcgaagtca cgtaccagaa catgagaagg gtggccgccc acgccagaca gcaccacagg
     5641 cacagcgcgt ggatgcggta cagcgactgg aattgcaacc aggtgcagaa cacgacgccg
     5701 aagaccgtgc ccgcgttgag cgtcagccag taccagcggg gaaaacgcgc cccggccagc
     5761 aggcccacgc cggcacagag gacgacgccg tacgcggcga ggccgagcat cgggttgggg
     5821 aacccgaaca ccgcggcctg ctcgctcttc atgatgctgc cgcaggacac caccgggttc
     5881 atgctgcagc ccgggacgta gtccgggtcc gcgagcagct tgaacttgtc gagggtgatg
     5941 acccaggagg cgagcagccc cgccgccgcc gtgaggacga ggagcagggc gagaccgcgc
     6001 ccgcccccgg ccgcccggga gtcgtccggc cggggaacgg cggcgggccg ggcggcggag
     6061 gcctgcaccg ggacccggcc cgtcgtggcg gcggcgcgca tcagccgcgc agcctgcgca
     6121 cgggcagcag gcagtgggcc gcgttcagca tggtgtcctc ggacccggcg aagtcgcgca
     6181 gcgcctcctc ggagacgggg ctgccgggct tgccctcggg ccaggccacg gtggtgatca
     6241 tgaagtaggc gtggccgcgc tgctcgacgg cggcgagcca ctcgggcggg acgacgcact
     6301 gcgccttgac gtggggcatg ttcacgacgg cctgctcggc ctcgacgagg aggctgaccg
     6361 gcagcgacgg ggtgcgggca ccgtcgagta cggggccgcc gagcggcagg ttctcgttgc
     6421 gcaggagagt gcgcatggcc tcggcggtgg cttcggggcc gccttcggca tcgcccaggg
     6481 agtaggccag gagaaaggcc atgtcccgct cgtcctccgg gtgttcgccg ctccaggcga
     6541 ggacggcgag ggtgccgaga tcggtcacgc ggaaggtgcg ctgttcgttg gaggttgagg
     6601 tcatggggtg cacgctatag acgcgtggag ggcacccgaa tccctttgtc acctggttgg
     6661 cgcagcgcac cagcggcatc acacgatggg ggcagcgggc cccgctgatt gacacgggcc
     6721 agtccacgga tgccgaggag tgggtgccgg agatgccgaa gtcccggccc gggagatgcc
     6781 gtagagccgg tcccggagat gccgaagggc cggtcccggc ggtgtgtcgc cggaccggcc
     6841 ccatcgcctc cgggtgcgga ggcgtccccg aggggcgttc agtcgttggt gcccgagttg
     6901 ccgaaggccg ggttgagggc gccgaccagg ttggcggtgt tgccgaccac gttgaccggg
     6961 acgctgaccg ggacctggcc gaggttgccg gaggcgacac ccggggagcc gaccgccgcg
     7021 ccctcggcgc tggcgccgtc gccgctggcg aaggcgctgc cggacgcggc gcccgcggcg
     7081 aggccggcgg cggcgatgac gagggcggcc ttcttgacat tcttcatgat caaaaccttt
     7141 ccttgggttt actgaagcct atggacatga atgcggaaag ctccgcaata acacgcccac
     7201 gcgtccccgc ccctcattcc cccgttactt gattacttgg ggagcggaag tccaccgagc
     7261 atcttcgtcg gaccgccacc cgagttcagg ccctctgcgg cgtccttcac ggtgttgacg
     7321 acggagtcct tgttctcggt gtccagcatg ttcgtgctga ccggcttggt gtccagcatc
     7381 gactgaccga gaacggtctc caggccgccg ttcaggctgg tgggcgtcag gtcgctggcg
     7441 aatgcgggtg cggcggcacc ggcaatggcc atcgacccgg ccaggacagc ggcagccttg
     7501 agggacttca tcgtgttcct ttcttcggcg acttcggtcg cctttggagg caccgtgcag
     7561 gcatcgattg cctgtctctc gagttcacta cgcctaacga gcgcaggaca gtacggaaac
     7621 ccctgagagg aaacttcccc cggcccgcac ggatgaatat gggccaccat ttctcatatc
     7681 aacgggcgca ttttcgggcg gggttgacga cgccacccgc cgtcccgggt acgggagcgg
     7741 cgggtggcga aggtgcgggg accggcctca gaccggcagc ttgggcagcg gcagcccgtc
     7801 gaccggcagc ttcggcaggg cgggcaggcc cggcaggttc ggcaccggca ggccgccgcc
     7861 gaggagcgtg gcgacggcga agttgaccag gccggtgagg acggccggca cctccttggc
     7921 gatggccgcg acgtcggccg aggtgaccgc cttgacgagg gcctcgaccg acttctgcag
     7981 cgcggccagg gcgtcgccct tgaggtccat cggcgcctgc gcggccgggg cgccgccgag
     8041 cgggagctgc ggcgcggcgg ggagctgcgg ggtctcgggc agcgcggcgc ccttgggggc
     8101 cgccgccttg gccgcgtcga gcgcggtggt gacggcgctg gtgagcgtgg ccaggtccgc
     8161 ggcgggcacc gcgccgttgt ccgccttgag gacggcttgg aggaggtcgg tgaccggctt
     8221 gatgacaccg ccgatgtcgc cgagcgactt cacctgcccc agcagggcgt cggctcccgg
     8281 gacgggcacc tgcggcgcgg tccgtgccgc ctcgcgcgcc gtgtcgtcgt gggtcgcggc
     8341 gtagacgggc cccgcggtgc cgagcaggag ggcggtgcac aggaaggagg tcgcgatgcg
     8401 ccgtacaggc agagctcgca taggtcattt ccctttcgga gatgcgtcgg atcctgtgat
     8461 caccgtctaa acggcatcca cggtccgcaa ccgagcggcc acgcactgcg gcggcccgtt
     8521 tccgatggaa acggcatcag cgcaggtgag aaggaagggc ggcgggtgcc cgatggcccg
     8581 gcgggcgacg tccatccggg gtaccggagt actccacccg gaagcgcgca cgacgagcgg
     8641 cggccgcccc cgggaccggg gacgaccgcc gctgtgccga ctctgcgtca ggcgctgtac
     8701 gccgaacggc tgtacgtcag tcgttgacgc aggtgttgcc gaaggccggg ttcagcaggc
     8761 cgatgacgtt gatgctgttg ccgcacacgt tgacgggaac gtgcaccggc acctggacgg
     8821 cgttgcccga gatgacgccg ggggagttgg tggcggcacc gtgcgcgccg ctgtcggcgg
     8881 cggcgacacc ggcgccaccg gccacggcgg cggcggcaac ggcggacagg gcaagggcct
     8941 tggtggtacg cgacatggag tactgctcct tgttctgaat gtgctgaggt gctgaagccg
     9001 tgcgtgatgc ccggtgtggg gatcaactga gttccccatc agtcggttgt gcgcccagat
     9061 gagtgatgtc ttcctcgcgg ttcggccaca cgcttcacca atccgacaca cgccaccaag
     9121 tcatcagaaa ctcccggaat aaacgctact gttgcgcttc cttctgagtc tatttccgtc
     9181 atacgcgctc agatccacac atttaatgcg actaaccgca ccgtggaagg ccagtgccgt
     9241 catgcgtcat cttctgggcc cgcgtcgtgt gctcgtcgtc ctgctcgccc tgaccgggtg
     9301 cctcgcgctg cccggcaccg gcgccgccgc cccgggcacg ggcgccgcgg cccccggcgg
     9361 ggagaagccg cgcatcgcct tcgcccagcg ctaccacgcg gtccagcacg gcgggatcgt
     9421 ccgggccgcc aactcgtcga tcacctgccg ccgtccggtg tcccgcgcgg tcgccccgtg
     9481 cgcggacgtg cgccgcggcg ggcccggcgc gaaccacgac ttcgagatgt tctacacgga
     9541 catcgaccgc gacccgaaca cgtacaactc cagcgcgggc gaggtccggc tgcccgccgg
     9601 gtcccgggtc tcctacgccc ggctctactg gggcggcaac ctccgcgtcg gggagcagaa
     9661 gccgcccaag gacaacggcc gggtgctgat cgccgagccc ggcggcagct accgggccgt
     9721 cctcgccgac accctgacgg gccaccgggt cgcgggcggc gcggacgcgt tccaggcgtc
     9781 cgccgacgtc acctcgctgg tccgcggctc cggcgccggg ctctacaccg tcgcgcaggt
     9841 caacgtggcg atggggcact ccaaggccgg ggcgtggggc ggctggacgc tggtcgtggc
     9901 gtacgagaac gcggcgctgc cgaagcggtc gctcgccctg tgggacgggt tcgactcgtt
     9961 cggcgtaccg gggcggcggc acaccgtgcg catgcggggc gtgcccgtgg cgcccggcgc
    10021 gcggggcacg gtcggggtcg tcgcgtacga cggcgaccgg ggcgtgcgcg gggacgcggt
    10081 gcacgtgtcc gccgggcgcg gtcggcccgt gccgctctcg gaccacgcca accccgccgc
    10141 cgacgtactg aactccaccg tcagcgagcc gggccgaccg gcccgcagga gccccgcgta
    10201 cgccaacacc ctcggctacg actccgacgt gctgcgcctg ccggagcggc cgcgggggca
    10261 gcgcggcgac ttgacggtgc gggtgtccgc gcggcgggac gcggcctgga cgggtgtgct
    10321 gttcgccgcc gtcgacgtgc agcggtagcg cgtattccgt cgtcct
//
