LOCUS       NZ_BMVR01000004        22217 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000004
VERSION     NZ_BMVR01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 715038)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 673059
            Orig. end                         :: 695276
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22217
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22217
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22217
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12217](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12217)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            708..1577
                     /locus_tag="IE274_RS13210"
                     /old_locus_tag="GCM10010349_26920"
     CDS             708..1577
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946672.1"
                     /locus_tag="IE274_RS13210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26920"
                     /product="metallophosphoesterase"
                     /protein_id="WP_190115847.1"
                     /transl_table=11
                     /translation="MTTSAASRRAPRLFGISDLHIAYAENRKFVDELWPEHEGDWLIVA
                     GDIGEMMSDIEWALRTLTERFDTVIWSPGNHELWTPRDDPNQLRGEARYRHLVELCRGL
                     GVHTPEDPFPVWDGEGGPAVIAPLFLLYDYTFRPAGKHNKKDALAYAYETGVVCTDEVL
                     LHPDPYPTREDWCRARVALTKDRLDALDPELPTVLINHWPVVREPTRILHYPEFALWCG
                     TEATADWPVRYRAAAVVYGHLHIPRTIWHEGVPHIEVSVGYPREWQRERHPSPRLRQIL
                     PAPRPTGT"
     gene            1844..2671
                     /locus_tag="IE274_RS13215"
                     /old_locus_tag="GCM10010349_26940"
     CDS             1844..2671
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (33-194). E-value: 3.7e-14.
                     Score: 45.0. Matches aSDomain:
                     nrpspksdomains_IE274_RS13215_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984377.1"
                     /locus_tag="IE274_RS13215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26940"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_190115848.1"
                     /sec_met_domain="adh_short (E-value: 4.9e-31, bitscore:
                     103.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPSAPASDASESGSSRRTPGAAAPSGSRFTGRVAVVTGGASGIG
                     AATAVRLAAEGAAVVVSDVDADHGEQVAEGIRAKGGSAVFVRADVAEAADWDRVLAAAH
                     GFGPVGVLSSSAYACEIAPAHAMTRASWEHQLAVNLTGTFLGFKAVLPDLRAHRGAVVL
                     TSSVHAHTGIPGRPAYAASKGALVSLCGQLAVEYGPEVRVNAVLPGPVLTPAWGDVGAA
                     DRARSVAGTAAGRFGAPEEVAAAIAFLAADEASYITGTSLTVDGGWSVVKESA"
     aSDomain        1943..2425
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS13215_PKS_KR.1"
                     /evalue="3.70E-14"
                     /label="IE274_RS13215_PKS_KR.1"
                     /locus_tag="IE274_RS13215"
                     /protein_end="194"
                     /protein_start="33"
                     /score="45.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGASGIGAATAVRLAAEGAAVVVSDVDADHGEQVAEGIRA
                     KGGSAVFVRADVAEAADWDRVLAAAHGFGPVGVLSSSAYACEIAPAHAMTRASWEHQLA
                     VNLTGTFLGFKAVLPDLRAHRGAVVLTSSVHAHTGIPGRPAYAASKGALVSLCGQLA"
     CDS_motif       1949..2026
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS13215_0001"
                     /evalue="2.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="IE274_RS13215"
                     /protein_end="61"
                     /protein_start="35"
                     /score="17.1"
                     /tool="antismash"
                     /translation="VVTGGASGIGAATAVRLAAEGAAVVV"
     gene            2796..3941
                     /gene="dgoD"
                     /locus_tag="IE274_RS13220"
                     /old_locus_tag="GCM10010349_26950"
     CDS             2796..3941
                     /EC_number="4.2.1.6"
                     /GO_function="GO:0008869 - galactonate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dgoD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676976.1"
                     /locus_tag="IE274_RS13220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26950"
                     /product="galactonate dehydratase"
                     /protein_id="WP_190115849.1"
                     /transl_table=11
                     /translation="MKIDRVETFLAPPRWLFCRVETDEGVVGWGEPVVEGRADVVRAAV
                     DVLAEYLVGQDPLRIQDHWQVLTKGGFYRGGPVLSSAVAGLDQALWDIAGKTYGAPVHA
                     LLGGPVRDRARVYAWVGGDEPAVLAEHIAEQVEAGFTAVKMNAAGATSPLTTHAETAVV
                     VDRVAIAREALGPDRDVAVDFHGRFTPASARRVLTELAPLHPLFAEEPLLPDQSHLLPA
                     LVAASPVPIATGERLYSRAEFLPALTAGIAVAQPDLSHAGGITEVQRIAALAETYGALL
                     APHCPLGPIALAASLQLAFTTPNFLIQEQSRGIHYNKRADLLSYVVNTEPFRFADGHAR
                     RTSLPGLGVEVDEAAVRAADRGGHAWRNPVWRHPDGSFAEW"
     gene            4033..5676
                     /locus_tag="IE274_RS13225"
                     /old_locus_tag="GCM10010349_26960"
     CDS             4033..5676
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644101.1"
                     /locus_tag="IE274_RS13225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26960"
                     /product="cytochrome bc complex cytochrome b subunit"
                     /protein_id="WP_190115850.1"
                     /transl_table=11
                     /translation="MSERARNTGPGKRDTGPGKGERVADWADGRLGVHTLAKTQMRKVF
                     PDHWSFMFGEICLYSFLILILTGVWLTLFFEPSGIEVEYNGSYEPLKGVLMTRAYESTV
                     DISMEVRGGLLIRQIHHWAALVFVAGMLVHMMRVFFTGAFRKPREINWVFGWTLLMLGL
                     ITGLTGYSLPDDLLSGTGIRFAQGAILSVPVVGTYLSFFLFGGEFPGQDIIPRLFAVHV
                     LLLPGIMLGLVVAHLILVFYHKHTQFAGPGRTEKNVVGAPFLPIYVAKAGGFFFLVFGV
                     LALMGAIATINPVWALGPYRPDLVGTGAQPDWYLGFSEGLIRVMPSWEINAWGHTLQLG
                     VFIPFALFPLIMAAIGVYPFIESWVTKDKREHHIADRPRNAPVRTGLGVAWLTLYGVLM
                     VGGGNDLWATHFHLSINAITWFVRVAFFVAPPLAFVVTHRICLGLQRRDRDNALHGRES
                     GIIKRLPHGEYVEVHKPLSQAERYRLTAHEQPQPYEVGPLVDANGVIRKVPRSERLRAR
                     LSRAMYGPGAQVPKATAEEYRQLHSGDGHH"
     gene            5762..8035
                     /locus_tag="IE274_RS13230"
                     /old_locus_tag="GCM10010349_26970"
     CDS             5762..8035
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_26970"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_190115851.1"
                     /transl_table=11
                     /translation="MANNISGGNFRDVIQAQHVTVRQCVSGEVRAPRVPFMAPAAPGRL
                     VDRLPVRAVLDRVADARGERAAAEVVVVTGPPGIGKSGAVLHWSALRRDGFPGGVLYAD
                     MSPRGALEPADTRSVLESFVSALGTPRAEMPADMAPLAAYYRHLTAHEPCLVLLDDVVT
                     AGQVPSLLPGHPGSMVVLTSRLLLNGLRSVLPGSDPEYVRLAGLDDESCRELFLDTAGR
                     AMTAELTDRGQELLRTVIPAFAGLPAAARLAGARAADPLEGGVEEFVRRLLALPTFQEA
                     LTVPDDPHTYSLRSVFADSYAALDPATATVFRGLGLNPTPEFADALVDELAGGPDAGAR
                     VRRTLLNSNLLDRPAPGRCRMNGLLHEYAAALARTDAAETGAVAARITDWYLRRAAAAE
                     HLVSTRWRRAEIFGRPALLDGVFGSDSEALDALEPDRENAAALTGLEFTRGHDLLVCDL
                     AEALRGFFFRRKHHTLWVEVAERGVRAAERMVAARAAGVAGAANVAGAAGARPGPAAAG
                     ADTAEGAEAAGDAEAPDNAALVLARCHYELAFALFDQSGPDSVERAGHHYGLALSQARA
                     AGHARTESSALEGLGQVAMEQGRPQDALDCFRQALRALGDLAHPRGRALLDYHMGRAAS
                     AAHLHEEAAASLLGARRLFAALPTPDRYNEARALTRYAQARLAADRADEAVTPLDEAIA
                     LLQERGAPKEEADARLTRGDAWAAHGDEARAREDWRAALATYRELGSVGAAGARERLGE
                     RPDA"
     misc_feature    6464..6466
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8039..9868)
                     /locus_tag="IE274_RS13235"
                     /old_locus_tag="GCM10010349_26980"
     CDS             complement(8039..9868)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS13235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_26980"
                     /product="hypothetical protein"
                     /protein_id="WP_190115852.1"
                     /transl_table=11
                     /translation="MREPNHVHPAAPGAPARWLTVAPERTVLGVIHNVTSATRLLDLLT
                     VFDGDRRVQTVFTRTGSSPFADGIAEFAAARELPFLPWDEAVKSEFDLAVSTSRGGDLH
                     SISAPLIGAPHGAGYNKRLSSREPGAGSREPGAFGLTAEWLVHDGELIPSAVVLSHEEQ
                     LARLRDGCPEALPAAHVVGDPCMDRLRASLPFRAEYRAALGVRPDQRLLVLSSTWGRHS
                     LLGAAGDLVLRALAELPSDSYRVLAAVHPNAWYGHGGWQVRSWLRPHLDAGLLLPPPAG
                     DTWRAALCAADAFIGDHGSVTLYAAGLGLPGLLGAFDTEAVAAGSPMAALGAALPRVSP
                     TRPLAAQLELAARDQPTDPRLGAATSQITSHPGEASARLRRLCYRVLALDEPAAPIAPW
                     PVGVPQDLPPTPRSPVERPLFVEVRVTSGGGAGEPDGGVGGVGATGPNRPTDPTAPTEL
                     LIRRHPAPARAAATPCPALTDAHVAVTAGEPEARWALAADVVTARAPAAGPHVAALTAE
                     LFTAHPGCALVAVPQEDGGCHLHTRSGTFYLASWDSPRAWTAPSLTASVMYACLLQHGD
                     DWEGDVLVRLTPDGAPARLRVRRLGADPVPYSN"
     gene            complement(10001..12217)
                     /locus_tag="IE274_RS13240"
                     /old_locus_tag="GCM10010349_26990"
     CDS             complement(10001..12217)
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644104.1"
                     /locus_tag="IE274_RS13240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26990"
                     /product="terpene synthase family protein"
                     /protein_id="WP_190115853.1"
                     /sec_met_domain="T1TS (E-value: 8.4e-83, bitscore: 274.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQSSRPFELPSFYMVHPARLNPHTEEARSHTREWARTMGMLEGS
                     GVWDTADLEAHDYALLCAYTHPDCDSAALSLVTDWYVWVFFFDDHFLELFKRTQDRVGG
                     KAYLDRLPAFMPMDLATPMPEPTNPVEAGLADLWRRTVPSMSLEWRARFAESTRNLLNE
                     SLWELSNINAHRVANPVEYIEMRRKVGGAPWSAGLVEYATGAEVPAAVARSRPLRVLRD
                     TFADAVHLRNDLFSYQREVEEEGELSNGVLVLETFLGCSTQEAADAVNDLLTARMQQFE
                     DTTFTELGPLCAEMALPPGQCADVLAYVKGLQDWQSGGHEWHMRSSRYMNEGATDRPSP
                     LAGPTGMGTSASGIKALMAATGAQRVRRFTHVPYQRVGPSRIPDFDLPYTTTLSPHLDH
                     SRRETVDWAARMGMLQPQPGVPASHIWDAHKLAGYDFPLCAAGLHPDATPEQLDIGSCW
                     LTWGTYGDDYYPVVFGRPRDLLGAKVCTDRLLLFMPLDCSPTPPPANALERGLADLWAR
                     TAGPMNAEGRAALHKTLVDMTDSWLWELGNQAQHRIPEPVDYMEMRRHTFGAHFTMSLS
                     RFGHGKRVPEEIYATAPLQNLENAAADYSMLMNDVFSYQKEIEYEGEVHNAILVVQNFF
                     DCDYPAALGIVDDLMRSRMSQFQHVVAHELPVLYDEFDLGQEARDTLDDYVEELKHWMA
                     GIYIWHRDCRRYRQQDLSHGPLPAPSGLGMDVVRPGWLRELAAP"
     gene            complement(12344..12490)
                     /locus_tag="IE274_RS13245"
                     /old_locus_tag="GCM10010349_27000"
     CDS             complement(12344..12490)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS13245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_27000"
                     /product="hypothetical protein"
                     /protein_id="WP_190115854.1"
                     /transl_table=11
                     /translation="MAEQRIDLIDAEITRLTELRQRLALRVAAIRAVAGIDDRLDASSR
                     TGV"
     gene            12518..12904
                     /locus_tag="IE274_RS13250"
                     /old_locus_tag="GCM10010349_27010"
     CDS             12518..12904
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IE274_RS13250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GCM10010349_27010"
                     /product="hypothetical protein"
                     /protein_id="WP_372447006.1"
                     /transl_table=11
                     /translation="MAAARPGSRGSPRRRCSFAVVAPAGALALGGLGGAPGLVALALGT
                     LLLDVAMQSGMVANQVRIFALSSEARSRLNTAYMTCAFIGGAAGSSLGALAYATWGWAG
                     VCALVAVLGAASVPVVVRRGLRRS"
     gene            13035..13892
                     /locus_tag="IE274_RS13255"
                     /old_locus_tag="GCM10010349_27020"
     CDS             13035..13892
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454375.1"
                     /locus_tag="IE274_RS13255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27020"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_190115855.1"
                     /transl_table=11
                     /translation="MEQDPDVPTRVRAVIAAAGVTQREFARRIVMDPSKLSRSLGGTRR
                     FTAAELARIADTTDVDAAWLLGTRGGADPAAVRPAAPRGRRAATPPEGRPLQIIRETVR
                     LIADHGFHAVRVQDIAKACETSTAAIHYHFPGRDDLLEAAARWCMDEDTARRAARIADA
                     ADAADELRQLIELQTPRTAQQRDQWSVWLDLWAEAARSTAVGRLHTEYYRQWRATVADV
                     VRRGVAQGAFRPVDPEAAALHLTALIDGLATQVLAGAPDGPGTRPDDMHAALLAHVDVA
                     LAAR"
     gene            13985..14881
                     /locus_tag="IE274_RS13260"
                     /old_locus_tag="GCM10010349_27030"
     CDS             13985..14881
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003946448.1"
                     /locus_tag="IE274_RS13260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27030"
                     /product="3-keto-5-aminohexanoate cleavage protein"
                     /protein_id="WP_190115856.1"
                     /transl_table=11
                     /translation="MPVNDNVIITCALTGAGDTVRKSPHVPVTPEQIARDAVRAAEAGA
                     AVVHIHVRDPGTGAPSRDPRLYREVVERVKETGTDVVINLTAGMGGDLVIDPDQPLTEL
                     GELPGTDLVGGLDRLPHVEDLLPDICTLDCGSLNFGDNLYISTPDMLRQGAKRIQELGV
                     RPELEIFDTGQLWFAKQLLAEGLLDNPTVFQLCMGIPWGAPADPGVLQSMVNMLPEGAQ
                     WASFALGRMQMPWVAQSILLGGQVRVGLEDNLYLGKGNKATNAELVERAVQITENLGSR
                     VATPDEARTKLGLKPRT"
     gene            14902..15879
                     /locus_tag="IE274_RS13265"
                     /old_locus_tag="GCM10010349_27040"
     CDS             14902..15879
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644767.1"
                     /locus_tag="IE274_RS13265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27040"
                     /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding
                     domain-containing protein"
                     /protein_id="WP_190115857.1"
                     /transl_table=11
                     /translation="MTVTTPEEVRRVACVGAGVIGGGWVAHFLARGYDVTAWDPAPDAE
                     QRLRRLVDAAWPALTRLGLAEGASRDRLTVAATLEEAVADAQFVQESAPEKLELKRDLL
                     ARLDAAAPAGAVIASSTSGYPMTDMQTTAADPGRLVVGHPFNPPYLIPLVEVVGGERTT
                     DEAVAWASRFYEVAGKSVITMKSEVPGFIANRLQEALWREALHMVANGEATVQEIDDSI
                     TEGPGLRWAFMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLEAPELDKELYDAVVA
                     GCDEAAAGRTIADLVAERDQGVIDVLRATGRLPRQTTADTEGTA"
     gene            15876..16379
                     /locus_tag="IE274_RS13270"
                     /old_locus_tag="GCM10010349_27050"
     CDS             15876..16379
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644768.1"
                     /locus_tag="IE274_RS13270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27050"
                     /product="thioesterase family protein"
                     /protein_id="WP_190115858.1"
                     /sec_met_domain="4HBT_2 (E-value: 3.9e-29, bitscore: 96.7,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTREIARRLPLYRQVVPPEWIDYNGHMSEGYYSLAFGFATDAMMD
                     ATGLHAAYRAATGCSLYTVEAHLRYLRDVAEGAHLAVRTRVLGVHGKKAHFAHELYVVD
                     GAAADPAPDAGPVATTELLALHVDQELGRAVAFPDAVLERFAEFVEPAPEWAGRAIAAV
                     VAAK"
     gene            16550..17890
                     /locus_tag="IE274_RS13275"
                     /old_locus_tag="GCM10010349_27060"
     CDS             16550..17890
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058990.1"
                     /locus_tag="IE274_RS13275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27060"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_190115859.1"
                     /transl_table=11
                     /translation="MRLAILGGGGFRVPLVYRALLGDRAEGRITEVVLHDVDGARAGAI
                     ARVLADQADGVPAAPAVRVTTDLDDALRGADFVFSAIRVGGLEGRAADERVALAEGVLG
                     QETVGAGGIAYGLRTVPVAVDIARRVRRLAPEAWVINFTNPAGLVTEAMARHLGDRVIG
                     ICDSPVGLGRRVATLLGAEPGRAWLDYVGLNHLGWLTGLEVDGQDLLPRLLGDRDLLDS
                     FEEGKLFGADWLQSLGAIPNEYLHYYYFNRETVHAYRTAERTRGAFLRDQQARFYDELR
                     NPEAAAFKTWDATRAEREATYMAHSREAAGAGERAPEDMESGGYERVALALMRAIARDE
                     RATLILNVRNRTTLPELDSDAIIEVPCLVDASGPHPAAVSPLPGHATGLVCAVKAVERE
                     VLAAADSGSRATAVKAFALHPLVDSVSVARRLVDGYRQAHPGLAYLT"
     gene            18002..18409
                     /locus_tag="IE274_RS13280"
                     /old_locus_tag="GCM10010349_27070"
     CDS             18002..18409
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719233.1"
                     /locus_tag="IE274_RS13280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27070"
                     /product="(2Fe-2S) ferredoxin domain-containing protein"
                     /protein_id="WP_190115939.1"
                     /transl_table=11
                     /translation="MSPAAPTVPAAPTAPPATRPCTLVVCRGCCCGDPVKHPGTDHVGQ
                     LARLRAAADRSGGRFAVRTSECLGPCGQANIVVVQPSRAGRAHGGRPAWVGFALDDASL
                     DDILTWAEAGGPGLAEPPDALTLQLVDPRQV"
     gene            complement(18406..18909)
                     /locus_tag="IE274_RS13285"
                     /old_locus_tag="GCM10010349_27080"
     CDS             complement(18406..18909)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645233.1"
                     /locus_tag="IE274_RS13285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27080"
                     /product="FBP domain-containing protein"
                     /protein_id="WP_190115860.1"
                     /transl_table=11
                     /translation="MRALGDKEIRASFVNCSKGEARRLTLPAGFAETPWSDLDFLGWRD
                     PKAPDRGYVVAERGDELVGIALRASTGARRSMLKSSICSVCVTPQAGSGIALLVAPRAG
                     EAGRQGNSVGLYVCADLACSLYVRGKKTSALARRFDESLTPEEQNERTVRNLTGFLDQV
                     LARA"
     gene            complement(18923..19702)
                     /locus_tag="IE274_RS13290"
                     /old_locus_tag="GCM10010349_27090"
     CDS             complement(18923..19702)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982734.1"
                     /locus_tag="IE274_RS13290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27090"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190115940.1"
                     /transl_table=11
                     /translation="MERGTSASPAAAGTPHPLDNPGLASLEGPHAHFAERRGRVARYPD
                     AVSPWLGMPTAPDAADWADLAAFAGPDGEVPLPGVAVDVPAGWEVTFDVAGVQLVDGDI
                     PAAPDAGTVRLGPEDVPEMLDLVARTRPGPFRERTIELGTYLGIRHEGALVAMAGERLH
                     PPGWTEISAVCTDPAYRGHGLASRLVLAVAYGIRERGEIPFLHTAARNTGAVRLYESLG
                     FRLRRNISFRAARTTAASEAGRRALTGKNEKTAMRSD"
     gene            complement(19717..20637)
                     /locus_tag="IE274_RS13295"
                     /old_locus_tag="GCM10010349_27100"
     CDS             complement(19717..20637)
                     /EC_number="1.-.-.-"
                     /NRPS_PKS="Domain: PKS_ER (21-242). E-value: 2.3e-39.
                     Score: 127.3. Matches aSDomain:
                     nrpspksdomains_IE274_RS13295_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018551041.1"
                     /locus_tag="IE274_RS13295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_27100"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_190115861.1"
                     /sec_met_domain="ADH_N (E-value: 3.1e-10, bitscore: 35.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.7e-13, bitscore:
                     45.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKAYVFTRHGGPEVEALVDREPPEPGPGQLLIAVRAAGVNPVDY
                     KLRGGYRRPGQAPAALPEVLGSEAAGVVARTGPGVEGFAVGDAVFGSTLTGGYAEYTLL
                     PVAIAAHQPEGLSFAEAATLPVAAATAYDGVRQLALPAGATLLVTGAGGGVGGNVVRLA
                     RHLGLRVIGTASEGKKDVVESLGAAHVASGPDLVERIRAAAPDGVDGVFDLVGGDHLRA
                     VADVVADRTKLITAGGKQIVGELGGSAVARARDAATLDAVAELAAAGVLRPHITATYPL
                     DRAGEALRAVETGHALGKVVIEVGA"
     CDS_motif       complement(19801..19839)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS13295_0003"
                     /evalue="6.40E+01"
                     /label="PKSI-ER_m4"
                     /locus_tag="IE274_RS13295"
                     /protein_end="279"
                     /protein_start="266"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="AAGVLRPHITATY"
     aSDomain        complement(19912..20574)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS13295_PKS_ER.1"
                     /evalue="2.30E-39"
                     /label="IE274_RS13295_PKS_ER.1"
                     /locus_tag="IE274_RS13295"
                     /protein_end="242"
                     /protein_start="21"
                     /score="127.3"
                     /tool="antismash"
                     /translation="EPPEPGPGQLLIAVRAAGVNPVDYKLRGGYRRPGQAPAALPEVLG
                     SEAAGVVARTGPGVEGFAVGDAVFGSTLTGGYAEYTLLPVAIAAHQPEGLSFAEAATLP
                     VAAATAYDGVRQLALPAGATLLVTGAGGGVGGNVVRLARHLGLRVIGTASEGKKDVVES
                     LGAAHVASGPDLVERIRAAAPDGVDGVFDLVGGDHLRAVADVVADRTKLITAGGKQIV"
     CDS_motif       complement(20242..20277)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS13295_0002"
                     /evalue="4.30E-03"
                     /label="PKSI-ER_m4"
                     /locus_tag="IE274_RS13295"
                     /protein_end="132"
                     /protein_start="120"
                     /score="10.7"
                     /tool="antismash"
                     /translation="AATLPVAAATAY"
     CDS_motif       complement(20407..20445)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS13295_0001"
                     /evalue="2.90E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="IE274_RS13295"
                     /protein_end="77"
                     /protein_start="64"
                     /score="10.7"
                     /tool="antismash"
                     /translation="LGSEAAGVVARTG"
     misc_feature    21070..21083
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 gtcgcgggca agcgctccag gagcagccgc agttggtcct tctgctcgct gatgctgcgg
       61 cgcagctcga cctgggtgcg ggcctcgaag ccggggcgct tgctgaactg gtggaccagg
      121 tgcagacagg ccgtcacgag cagccggtcg tgcaggcggg cggcgtcggc gctgagcagc
      181 gcgcgggtct ccggggcgct ggcgcggacc agggcggcgg cgagcttctc cggaccgagg
      241 tcgaaggcct gcacgtcgtc catgtcgagt tcgccgaggg cgcgcagggt gtggccgagg
      301 gcgtagccga cggcgttctg ctcgtcgggc gcgatgggcg ggtcgtgcgg gcccgcggcg
      361 cgcatcgcgc ggcgcaccag ctcccgggcg agctggtaga ggtcggcctc gctgagggcg
      421 cgcttgtcgc cggtgaacga gaggagccgc ccgatgcgta ccgggcgttc gtcgaactcg
      481 gctcccggca ggctcttggg cggcagcagt aaccgtttca ccagcggcac catcaccgac
      541 gacgcgatcc gcagccccac tgtgccggcg tccactcaag cccccgtccg tgaccagatc
      601 cgcctccggg gcaccttaga ccgtggtggc ccacggcgca ccgaggtcgc ccggagcacc
      661 cggggcgcgg ctgccggacg cccgcgcgcg tcggttagcc tcacgtggtg acgacatctg
      721 ccgcatcccg acgggcgccg aggctgttcg gcatcagtga cctgcacatt gcctatgccg
      781 agaaccggaa gttcgtcgac gagctctggc cggaacacga gggtgactgg ctgatagtcg
      841 ccggtgacat cggcgagatg atgagcgaca tcgagtgggc cctgcgcacc ctcaccgagc
      901 gcttcgacac ggtgatctgg tcgcccggca accacgagct gtggacgccc cgcgacgacc
      961 cgaaccaact gcgcggcgag gcccgctacc gccacctcgt ggagctgtgc cggggacttg
     1021 gcgtgcacac ccccgaggac ccgttcccgg tctgggacgg cgagggcggc cccgcggtca
     1081 tcgccccgct gttcctcctg tacgactaca cgttccggcc cgcgggcaag cacaacaaga
     1141 aggacgccct cgcgtacgcg tacgagaccg gcgtggtctg cacggacgag gtgctcctgc
     1201 acccggaccc gtacccgacc cgcgaggact ggtgccgcgc ccgcgtcgcg ctcaccaagg
     1261 accggctcga cgccctcgac cccgagctgc cgaccgtcct catcaaccac tggccggtcg
     1321 tccgcgagcc cacccgcatc ctgcactacc ccgagttcgc cctgtggtgc ggcacggagg
     1381 cgaccgccga ctggcccgtg cgctaccgcg cggcggccgt cgtctacggc catctgcaca
     1441 tcccgcgcac catctggcac gagggcgttc cgcacatcga ggtctccgtc ggctacccgc
     1501 gcgagtggca gcgcgaacgg cacccctcgc cccggctgcg gcagatcctg cccgcacccc
     1561 ggcccaccgg gacctgacac ccgcgccacc tccccgtctc cccgaggggc gggcgcgggt
     1621 gcggccgcag gcgtgggcgg ggcggtcgcg acatccccgg cggccgtcga gggcagcgtg
     1681 gcggcggagt ccggagggcc ccgcacctgg gaccgcgcat agagtggacg gcgcatgcca
     1741 tcagcggtca ccgctccccg gcgggccgtc cacgcggcac cgccgcgcgg cgcgggcgcc
     1801 ggggagcagc cgcgccgccc acccgcacga ggggacgccg cacgtgaacc caagcgcacc
     1861 cgcctccgac gcctccgagt ccgggagttc ccgccgcact ccaggcgccg ccgccccgtc
     1921 cggctcccgc ttcaccggca gggtcgccgt cgtcaccggc ggcgcctccg gcatcggtgc
     1981 cgccaccgcc gtccgcctcg ccgccgaggg cgcggccgtc gtcgtgtccg atgtggacgc
     2041 cgaccacggt gagcaggtcg cggagggcat ccgggccaag ggcggcagcg cggtgttcgt
     2101 ccgcgcggac gtcgccgagg ccgccgactg ggaccgggtc ctcgcggccg cgcacggctt
     2161 cgggcccgtc ggcgtcctct ccagcagcgc ctacgcctgc gagatcgccc ccgcccacgc
     2221 catgacccgg gcctcctggg aacaccagct cgcggtcaac ctcaccggca cgttcctcgg
     2281 cttcaaggcc gtcctgcccg acctgcgcgc ccaccgcggc gccgtcgtcc tcacctcctc
     2341 cgtgcacgcc cacaccggca tcccgggccg ccccgcctac gcggcgagca agggcgccct
     2401 ggtctccctg tgcgggcagc tcgccgtcga gtacggaccc gaggtgcggg tcaacgcggt
     2461 cctgccgggg ccggtcctga cgcccgcgtg gggggacgtg ggcgcggcgg accgggcgcg
     2521 cagcgtggcg gggacggcgg ccgggcggtt cggggcgccg gaggaggtgg cggcggccat
     2581 cgcgttcctc gccgcggacg aggcgtcgta catcaccggg accagcctga ccgtggacgg
     2641 cggttggagc gtggtcaagg agtccgcctg agcggacccg gccgccgagc cccccgaccc
     2701 gccgcgcacc tgaacggacc cgaacctgac ggacccgaag ccgacggacc cgccccaagc
     2761 gggcacgccc ccgagcgagg agagaccgac accccatgaa gatcgaccgc gtcgagacct
     2821 tcctcgcccc gccccgctgg ctgttctgcc gcgtcgagac cgacgagggc gtggtcggct
     2881 ggggcgaacc cgtcgtcgag ggccgcgccg acgtcgtgcg cgccgccgtg gacgtactcg
     2941 ccgagtacct ggtcggacag gacccgctgc ggatccagga ccactggcag gtgctcacca
     3001 agggcggctt ctaccgcggc gggcccgtcc tctccagcgc cgtcgcgggc ctcgaccagg
     3061 cgctgtggga catcgcgggc aagacgtacg gcgcacccgt gcacgccctg ctcggcggtc
     3121 cggtgcggga ccgggcgcgg gtgtacgcct gggtgggcgg cgacgagccc gccgtgctcg
     3181 ccgagcacat cgccgagcag gtcgaggcgg gcttcaccgc cgtgaagatg aacgcggccg
     3241 gagcgacctc gccgctcacc acgcacgccg agaccgccgt cgtcgtcgac cgcgtcgcca
     3301 tcgcccgcga ggccctcggc ccggaccggg acgtggccgt cgacttccac ggccgcttca
     3361 ctcccgcgag cgcccgccgc gtcctcaccg aactcgcccc gctgcacccc ctgttcgccg
     3421 aggagccgct cctgcccgac cagagccacc tgctgcccgc cctggtcgcg gccagccccg
     3481 tccccatcgc caccggcgaa cgcctctaca gccgcgccga gttcctgccc gccctcaccg
     3541 cgggcatcgc cgtcgcccag cccgacctgt cgcacgcggg cggcatcacc gaggtgcagc
     3601 gcatcgccgc actcgcggag acgtacggcg ccctcctggc cccgcactgc ccgctcggcc
     3661 cgatcgcgct cgccgccagc ctccaactcg ccttcaccac cccgaacttc ctcatccagg
     3721 agcagagccg cggcatccac tacaacaagc gcgccgacct cctctcgtac gtcgtgaaca
     3781 ccgagccgtt ccgcttcgcc gacggccacg cccgccgcac gtccctgccc ggcctcggcg
     3841 tcgaggtcga cgaggcggcg gtgcgggcgg ccgaccgggg cgggcacgcc tggcggaacc
     3901 ccgtgtggcg gcacccggac gggtcgttcg cggagtggtg aggccgccgg ggcggtgaaa
     3961 tcccctgggg cggaggcctg ttgaccgacg ggcggcgcac ctaccctggt agccgcccga
     4021 ggggggagcc gcatgagcga acgcgcccgc aacaccggcc ccggcaagcg tgacaccggc
     4081 cccggcaagg gggaacgtgt cgccgactgg gcggacggcc gcctcggcgt gcacaccctc
     4141 gccaagaccc agatgcgcaa ggtgttcccg gaccactggt ccttcatgtt cggcgagatc
     4201 tgcctctaca gcttcctgat cctcatcctc accggcgtct ggctcaccct gttcttcgag
     4261 ccgagcggca tcgaggtcga gtacaacggc agttacgaac cgctcaaggg cgtgctgatg
     4321 acgcgcgcct acgagtcgac cgtcgacatc agcatggagg tgcgcggcgg gctgctcatc
     4381 cggcagatcc accactgggc ggcgctcgtg ttcgtcgccg ggatgctcgt gcacatgatg
     4441 cgggtgttct tcaccggcgc gttccgcaag ccgcgcgaga tcaactgggt gttcggctgg
     4501 accctgttga tgctcggcct catcaccggc ctgaccggct actcgctccc cgacgacctg
     4561 ctgtccggca ccggcatccg cttcgcgcag ggcgccatcc tgtcggtgcc ggtcgtgggc
     4621 acgtacctct ccttcttcct cttcggaggg gagttcccgg gccaggacat catcccgaga
     4681 ctcttcgccg tgcacgtcct gctgctgccg ggcatcatgc tgggcctggt cgtcgcccat
     4741 ctgatcctgg tcttctacca caagcacacc cagttcgccg ggccgggacg caccgagaag
     4801 aacgtggtgg gcgcaccctt cctgcccatc tacgtcgcca aggcaggcgg cttcttcttc
     4861 ctcgtcttcg gcgtcctcgc cctgatgggc gcgatcgcga cgatcaaccc cgtatgggct
     4921 ctcgggccct accggcccga tctcgtcggc accggcgccc agcccgactg gtacctcggc
     4981 ttctccgagg ggctgatccg ggtgatgccc agctgggaga tcaacgcctg gggccacacc
     5041 ctgcagttgg gcgtcttcat ccccttcgcg ctgttcccgc tgatcatggc ggcgatcggg
     5101 gtgtacccgt tcatcgagtc ctgggtcacc aaggacaaac gcgagcacca catcgccgac
     5161 cggccgcgca acgcccccgt ccgcacgggc ctcggcgtgg cctggctgac gctgtacggc
     5221 gtcctgatgg tcggcggcgg caacgacctg tgggccacgc acttccacct ctccatcaac
     5281 gccatcacct ggttcgtgcg cgtcgccttc ttcgtcgcgc cgccgctcgc cttcgtcgtc
     5341 acccaccgga tctgtctggg gctgcagcgc cgcgaccgcg acaacgccct gcacgggcgg
     5401 gagagcggca tcatcaaacg cctcccgcac ggcgagtacg tcgaggtcca caagcccctc
     5461 agccaggccg agcggtaccg cctcaccgcg cacgagcagc cgcagccgta cgaagtgggg
     5521 cccctggtcg acgccaacgg cgtgatccgc aaggtgcccc gctccgagcg gctgcgggcc
     5581 cgcctgtccc gggcgatgta cggcccgggc gcgcaggtgc cgaaggccac ggcggaggag
     5641 taccggcagc tccacagcgg cgacgggcac cactgaggcg caccggcccg gcggcgtcgg
     5701 cggggcgcga ggtggcgttc cgtccggcgg gcggccctgg aagactgccc gggtggattc
     5761 ggtggccaac aacatctcgg gcgggaactt ccgcgacgtc atccaggcgc agcacgtcac
     5821 ggtccggcag tgcgtgagcg gtgaagtacg ggccccgcgc gtgccgttca tggcgcccgc
     5881 cgcgcccggc cggctcgtgg accggctgcc ggtgcgcgcc gtcctcgacc gcgtcgccga
     5941 cgcccggggc gagcgtgccg ccgccgaggt cgtcgtggtg acggggccgc cgggcatcgg
     6001 caagagcggc gccgtcctgc actggtcggc gctgcggcgc gacggcttcc ccggcggtgt
     6061 cctgtacgcc gacatgagcc cgcgcggcgc gctcgaaccg gcggacaccc gctccgtcct
     6121 ggagtcgttc gtgtcggcgc tcggcacccc gcgcgccgag atgcccgccg acatggctcc
     6181 gctggccgcg tactaccgcc acctcaccgc gcacgaaccc tgtctggtgc tgctcgacga
     6241 cgtggtgacg gccggtcagg tcccctcgct cctgccggga caccccggga gcatggtcgt
     6301 tctcaccagc cgcctgctcc tgaacggtct gcgctccgtc ctgccggggt ccgaccccga
     6361 gtacgtccgc ctcgccgggc tcgacgacga gtcctgccgg gagctgttcc tggacacggc
     6421 gggccgtgcc atgaccgccg aactcaccga ccgggggcag gagttactgc ggaccgtcat
     6481 cccggccttc gcgggcctgc ccgccgccgc ccggctcgcc ggggcgcgcg ccgccgaccc
     6541 gttggagggc ggtgtcgagg agttcgtccg caggctcctg gccctgccca ccttccagga
     6601 ggcgctgacc gtgcccgacg acccgcacac gtactccctg cggtccgtct tcgcggactc
     6661 ctacgcggcc ctcgatcccg cgacggccac cgtgttccgc gggctcggcc tgaacccgac
     6721 gcccgagttc gccgacgccc tcgtcgacga gctcgcgggc ggccccgacg ccggcgcgcg
     6781 ggtgcggcgc accctcctca acagcaacct cctcgaccgc cccgcccccg gccgctgccg
     6841 catgaacggc ctgctccacg agtacgcggc cgccctcgcc cgcacggacg ccgccgagac
     6901 cggggcggtg gccgcgcgca tcaccgactg gtacctgcgg cgggccgcgg cggccgagca
     6961 cctggtgtcc acgcgctggc gccgcgccga gatcttcggc cgacccgctc ttctggacgg
     7021 cgtgttcggc agcgacagcg aggccttgga cgccctcgaa ccggaccgcg agaacgccgc
     7081 cgccctcacc ggcctggagt tcacgcgtgg ccatgacctc ctcgtgtgcg acctggcgga
     7141 ggcgctgcgc ggcttcttct tccggcggaa gcaccacacg ttgtgggtgg aggtggctga
     7201 gcggggggtg cgggcggctg agcggatggt ggcggcgcgg gcggcgggcg tggcgggcgc
     7261 ggcgaatgtg gcgggtgcgg cgggcgcgcg gccgggcccg gccgccgcag gtgcggacac
     7321 cgccgagggc gccgaagccg ccggagatgc cgaagcgccc gacaacgccg ccctcgtgct
     7381 ggcccgctgc cactacgagc tggcgttcgc cctcttcgac cagagcggcc cggacagcgt
     7441 cgagcgggcc ggtcaccact acgggctcgc cctgtcccag gcccgcgcgg ccgggcatgc
     7501 ccgcaccgag tcctccgcgc tggagggcct cggccaggtg gccatggaac agggccgccc
     7561 gcaggacgcc ctggactgct tccggcaggc gctgcgcgcg ctcggcgatc tcgcgcaccc
     7621 acgcggccgg gcgctgctcg actaccacat gggccgcgcg gcgagcgccg cgcacctcca
     7681 cgaggaggct gccgcgtccc tgctcggcgc ccgccgactc ttcgccgccc tgcccacgcc
     7741 cgaccgctac aacgaggccc gcgccctgac ccgttacgcc caggcccgtc tcgccgccga
     7801 ccgcgccgac gaggccgtca ccccgctgga cgaggcgatc gccctcctcc aggagcgcgg
     7861 cgcccccaag gaggaggccg acgcccgcct cacccggggc gacgcgtggg cggcgcacgg
     7921 tgatgaggcg cgggcacggg aggactggcg ggcggcgctg gcgacctacc gggagttggg
     7981 gagtgtgggg gcggcggggg cgcgggagcg gctgggggag cggcccgacg cgtgagcgtc
     8041 agttgctgta cggcacgggg tccgcgccga ggcgccgcac ccgcagccgc gccggtgcgc
     8101 cgtccggagt cagccgcacc agtacgtcgc cctcccagtc gtccccgtgc tggagcaggc
     8161 aggcgtacat cacggacgcg gtgagcgagg gggcggtcca ggcgcggggt gaatcccaac
     8221 tggctagata gaacgttcca ctgcgggtgt ggaggtgaca gccgccgtcc tcctgcggta
     8281 cggcgaccag cgcgcagccc gggtgggcgg tgaacaactc ggccgtcagc gcggccacat
     8341 ggggtccggc cgccggggca cgggccgtga ccacgtccgc cgcgagggcc caacgcgcct
     8401 caggctcgcc tgcggtgacg gcgacgtggg cgtcggtgag cgccgggcac ggcgtggcgg
     8461 cggcgcgggc gggggcgggg tggcgccgga tcaggagctc ggtcggcgcg gtcggatcag
     8521 tcggccggtt cggcccggtg gctcccacgc ccccaacgcc cccgtcgggc tcaccggccc
     8581 cgccgcccga cgtcacccga acctcgacga acagcggacg ctccaccggt gagcgcggcg
     8641 tcggcggcag atcctgcggt acgccgacgg gccacggcgc gatcggcgcg gcgggctcgt
     8701 ccagggccag gacgcgatag cagaggcggc gcaggcgggc cgaggcttcg cccgggtggg
     8761 aggtgatctg cgaggtggcc gcgccgagcc gggggtccgt cggctgatcc cgcgcggcga
     8821 gctccaactg cgccgcgagc ggccgcgtgg gcgagacgcg gggcagcgcc gcgccgagcg
     8881 ccgccatggg ggagcccgcc gccacggcct ccgtgtcgaa cgccccgagc agtccgggca
     8941 ggccgagccc cgccgcgtac agcgtgaccg agccgtggtc gccgatgaac gcgtccgccg
     9001 cgcacagcgc cgcccgccag gtgtcgcctg cgggcggcgg aagcagcagc ccggcgtcca
     9061 ggtggggtcg cagccaggag cgcacctgcc aacccccgtg cccgtaccag gcgttggggt
     9121 gcacggcggc aaggacgcga taggagtcgg agggcagttc ggcgagggcg cggaggacga
     9181 ggtcgcccgc ggcgccgagg agggagtggc ggccccaggt cgagctgagg acgagcaggc
     9241 gctggtcggg gcggacgccg agcgcggcgc ggtactccgc acggaagggg agggaggcgc
     9301 gcagccggtc catgcaggga tcaccgacga cgtgcgccgc gggcagggcc tcggggcaac
     9361 cgtctcggag gcgggcgagc tgttcctcgt gggagaggac gacggcggac ggtatcaact
     9421 caccgtcgtg caccagccat tcagccgtca ggccgaaggc tcccggctcc cggctcccgg
     9481 ctcccggctc ccggctgctg agccttttat tgtatccggc gccgtgcggg gcacctatga
     9541 gcggtgcgga gatgctgtgc aggtcgccgc cgcggctggt gctgaccgcc aggtcgaact
     9601 ccgacttgac cgcctcgtcc caggggagga acgggagttc gcgggcggcg gcgaattccg
     9661 cgatgccgtc cgcgaacggg gaggagccgg tgcgggtgaa cacggtctgc acccgccggt
     9721 cgccgtcgaa gacggtgagc aggtcgagca gccgggtcgc cgaggtgacg ttgtggatga
     9781 cgccgagcac ggtccgctcg ggggcgacgg tgagccagcg ggcgggggcg ccgggggcgg
     9841 ccgggtggac gtggttcggc tcccgcacgg cgcgcgccct ccccacgttc ccggggccgg
     9901 accgcgccgg ccccgggccg accccggtga tcggcccgac cgccgacctt acccgccccc
     9961 gtccggggcg cggccggccg acggccgggt caccgcgagg tcagggcgcg gccagctccc
    10021 gcagccagcc gggccgcacc acgtccatgc cgagcccgga cggtgcgggc agcggcccgt
    10081 gcgagaggtc ctgctggcgg tagcggcggc agtcgcggtg ccagatgtag atcccggcca
    10141 tccagtgctt cagttcctcg acatagtcgt cgagggtgtc ccgtgcctcc tggccgaggt
    10201 cgaactcgtc gtacaagacg ggcagttcat gtgcgacgac gtgctggaac tggctcatgc
    10261 gggacctcat gaggtcgtcg acgatgccga gcgccgccgg atagtcgcag tcgaagaagt
    10321 tctgcacgac gaggatcgcg ttgtgcacct cgccctcgta ctcgatctcc ttctggtaag
    10381 agaagacgtc gttcatgagc atcgagtagt cggcggcggc gttctccagg ttctgcaacg
    10441 gcgcggtcgc gtagatctcc tcgggcaccc gcttgccgtg cccgaagcgg ctgaggctca
    10501 tcgtgaagtg ggcgccgaag gtgtggcggc gcatctccat gtagtcgacg ggctccggga
    10561 tgcggtgctg cgcctggttg cccagctccc acagccagct gtccgtcatg tccaccaggg
    10621 tcttgtgcag cgcggcgcgc ccctccgcgt tcatggggcc cgccgtgcgg gcccacaggt
    10681 cggcgaggcc gcgctccagg gcgttggcgg gcgggggagt gggggagcag tccaggggca
    10741 tgaagagcag cagccggtcg gtgcacacct tggcgccgag caggtcacgg ggcctgccga
    10801 acaccacggg gtagtagtcg tccccgtacg tcccccaggt cagccagcac gagccgatgt
    10861 cgagctgctc cggggtggcg tccgggtgca ggcccgcggc gcacagcggg aagtcgtacc
    10921 cggcgagctt gtgggcgtcc cagatgtgcg aggcgggcac gcccggctgc ggctggagca
    10981 tgcccatgcg ggcggcccag tcgacggtct cgcgccgcga gtggtcgagg tgggggctga
    11041 gggtggtcgt gtacggcagg tcgaagtcgg ggatccggga ggggccgacc cgctggtacg
    11101 ggacgtgcgt gaagcggcgc acgcgctggg cgccggtcgc ggccatgagg gccttgatgc
    11161 cgctggccga cgtgcccatg ccggtggggc ccgcgagcgg cgacgggcga tcggtggcgc
    11221 cctcgttcat gtaccggctg gagcgcatgt gccactcgtg gccgcctgac tgccagtcct
    11281 ggagcccctt gacgtacgcg aggacgtccg cgcactgccc gggcgggagt gccatctcgg
    11341 cgcacagcgg gccgagttcc gtgaacgtcg tgtcctcgaa ctgctgcatc cgggccgtga
    11401 ggagatcgtt gacggcgtcc gcggcctcct gcgtggagca gccgaggaag gtctccagga
    11461 ccaggacgcc gttgctcagc tcgccctcct cctcgacctc ccgctggtag gagaacaggt
    11521 cgttgcgcag gtgcacggcg tcggcgaacg tgtcccgcag gacccgtagc ggccgggacc
    11581 gcgccaccgc cgccgggacc tccgcgcccg tcgcgtactc cacgagcccc gccgaccagg
    11641 gggcgccgcc caccttgcgg cgcatctcga tgtactcgac ggggttcgcg acgcggtgcg
    11701 cgttgatgtt ggacagctcc cacagcgact cgttgaggag gttgcgggtg ctctcggcga
    11761 agcgggcccg ccactccagg gacatgctgg gcaccgtgcg cctccacagg tcggcgaggc
    11821 ccgcctccac cgggttggtg ggctcgggca tcggcgtcgc gaggtccatc ggcatgaacg
    11881 cgggcagccg gtccaggtag gccttgccgc ccacccggtc ctgggtgcgc ttgaagagct
    11941 ccaggaagtg gtcgtcgaag aagaacaccc acacgtacca gtcggtgacc agggacaggg
    12001 ccgcgctgtc gcagtccggg tgcgtgtacg cgcacagcag ggcgtagtcg tgcgcctcca
    12061 ggtcggccgt gtcccagacc ccggagccct ccagcatccc catggtccgc gcccactccc
    12121 gggtgtgcga acgcgcctcc tccgtatggg ggttgaggcg tgccggatgc accatgtaga
    12181 aactcggcag ttcgaagggg cgtgacgact gcggcatacg ggtgtctctc ctcgcggacg
    12241 gcgtacgggc agccgagcac tacccgtgcc gcgccacccg aagccgtgcg ccccctccag
    12301 tcacaccatc gcgtgatacg cctcgccgaa atcggccccc gcgtcaaaca cccgtacggg
    12361 acgacgcgtc gagccggtcg tcgatcccgg ccaccgcgcg gatcgccgcg acgcgcagcg
    12421 cgagccgctg ccgcagctcc gtcaggcggg tgatctccgc gtcgatcagg tcgatgcgct
    12481 gctcggccac gccggggccg agcccgcacc tcctgcggtg gccgccgccc ggccagggag
    12541 ccgagggagc ccgcgccgcc ggtgctcgtt cgcggtcgtc gccccggcgg gagccctcgc
    12601 cctcggtggg ctcggcggcg cgcccgggct cgtggccctg gccctcggca cgctgctcct
    12661 ggacgtggcc atgcagtccg ggatggtcgc caaccaggtg cggatcttcg ccctgagcag
    12721 cgaggcgcgc agccgcctca acacggccta tatgacgtgc gccttcatcg gcggcgcggc
    12781 gggctcgtcg ctcggggcgc tggcgtacgc gacctggggc tgggcgggcg tgtgcgcgct
    12841 ggtggcggtg ctgggggcgg cgtcggtgcc ggtggtggtg cggcgagggc tgcgtcggag
    12901 ctgaggtgag ttgaggtgag ccgaggtgac tgatgcatca gtcagcatcg caatggcgtg
    12961 aaactgtgag tgcatccgga gggaccttga agcttgcgtt gtgctgaact caatgcgcgg
    13021 gtacggtgac cggcatggag caagaccccg acgtccccac ccgtgtccgt gcggtcatcg
    13081 ccgcggcggg cgtgacccag cgcgagttcg cgcggcggat cgtcatggat ccgtcgaagc
    13141 tgtcgcgctc cctgggcggc acccggcgct tcacggcggc cgagctggcc cggatcgccg
    13201 acaccaccga cgtcgacgcg gcctggctgc tcggcacccg cggcggcgcg gacccggcgg
    13261 ccgtccggcc cgcggccccg cgcggacgcc gggccgcgac gccgccggag ggccgcccgt
    13321 tgcagatcat ccgcgagacc gtccgcctca tcgccgacca cggcttccac gccgtccgcg
    13381 tccaggacat cgccaaggcc tgcgagacca gcacggccgc catccactac cacttcccgg
    13441 gccgtgacga cctcctggag gcggccgcgc gctggtgcat ggacgaggac accgcccgca
    13501 gggccgcacg catcgccgac gcggccgacg ccgccgacga actgcgccag ctcatcgagc
    13561 tccagacccc gcgcaccgcc cagcagcgcg accagtggag cgtctggctc gacctgtggg
    13621 ccgaggcggc ccgctccacc gccgtcggcc gcctgcacac cgagtactac cggcagtggc
    13681 gtgccaccgt cgccgacgtc gtccggcgcg gcgtcgccca gggcgcgttc cggcccgtcg
    13741 accccgaggc ggccgcgctg cacctgaccg ccctgatcga cggcctcgcc acccaggtcc
    13801 tcgccggtgc cccggacggc cccggcaccc ggcccgacga catgcacgcg gccctgctcg
    13861 cccacgtgga cgtcgcgctc gccgcgcgct gagccccggc cccgtaagcc cgatacctcc
    13921 ggtacgcgtc cccgtacgca ctccgcacga ccgcaccccc cccgcctccg aaagggagtc
    13981 cggcatgccc gtgaacgaca acgtcatcat cacctgtgcc ctcaccggcg ccggcgacac
    14041 cgtccgcaag agcccgcacg tgcccgtcac acccgagcag atagcccggg acgccgtccg
    14101 ggccgccgag gccggggccg ccgtcgtgca catccacgtc cgcgaccccg ggaccggcgc
    14161 cccgtcccgc gacccccggc tctaccgcga ggtcgtcgag cgcgtgaagg agaccggcac
    14221 cgacgtcgtc atcaacttga cggcgggcat gggcggggac ctggtgatcg acccggacca
    14281 gccgctgacg gagctcggcg aactgcccgg caccgacctc gtcggcggcc tcgaccgcct
    14341 cccgcacgtc gaggacctgc tgcccgacat ctgcaccctc gactgcggct ccctcaactt
    14401 cggcgacaac ctctacatct ccacgcccga catgctccgc cagggcgcca agcgcatcca
    14461 ggagctgggc gtacggcccg agttggagat cttcgacacc gggcagctgt ggttcgccaa
    14521 gcagctcctc gcggagggcc tcctcgacaa ccccaccgtc ttccagctct gcatgggcat
    14581 cccgtggggc gcccccgccg acccgggcgt cctccagtcc atggtcaaca tgctccccga
    14641 aggcgcccag tgggccagct tcgcgctcgg ccgcatgcag atgccgtggg tcgcgcagtc
    14701 catcctgctc ggtggccagg tccgcgtggg tcttgaggac aacttgtacc tgggcaaggg
    14761 caacaaggcc accaacgcgg agctcgtcga gcgcgccgtc cagatcaccg agaacctcgg
    14821 gtcgcgcgtc gccaccccgg acgaggcccg cacgaagctc ggcctcaagc cccgcacctg
    14881 atctccacgg aggaccgcac catgaccgtg accacccctg aagaagtccg ccgtgtcgcc
    14941 tgcgtcggtg ccggagtcat cggcggcggc tgggtagccc acttcctggc ccgtggctat
    15001 gacgtcaccg cctgggatcc cgcgcccgac gccgagcagc ggctgcggcg gctcgtcgat
    15061 gccgcctggc ccgcgctcac ccggctcggg ctcgccgagg gcgcgtcccg ggaccggctg
    15121 accgttgccg cgacgctcga agaggccgtc gccgacgcgc agttcgtgca ggagagcgcg
    15181 cccgagaagc tggagctgaa gcgcgatctg ctcgcgcggc tcgatgccgc cgcgccggcc
    15241 ggggccgtca tcgcctcgtc gacctccggc tatcccatga ccgacatgca gaccacggcc
    15301 gccgaccccg gccgcctcgt cgtcgggcac cccttcaacc cgccgtacct gatcccgctc
    15361 gtcgaggtcg tcggcggcga gcggaccacc gacgaagccg tggcctgggc gtcgcgcttc
    15421 tacgaggtcg cgggcaagtc cgtcatcacc atgaagagcg aggtgcccgg cttcatcgcc
    15481 aaccgcctcc aggaagccct gtggcgcgag gcgctgcaca tggtcgccaa cggcgaggcc
    15541 accgtccagg agatcgacga ctccatcacc gaaggccccg gcctgcgctg ggcgttcatg
    15601 ggccccatgc tcaccttcgc gctcgcgggc ggcgagggcg gcatggccca tatgctcgac
    15661 cacttcgggc cgtccctgaa gtccccgtgg acgcggctcg aagcacccga actcgacaag
    15721 gagctgtacg acgcggtggt cgccgggtgc gacgaggccg ccgccgggcg caccatcgcc
    15781 gacctcgtcg ccgagcgcga ccagggcgtc atcgacgtac tgcgggcgac gggcagactg
    15841 ccgcggcaga ccaccgccga caccgaggga accgcatgac cagggagatc gcccggcgtc
    15901 tgccgctgta ccggcaggtc gtcccgcccg agtggatcga ctacaacggc catatgagcg
    15961 agggctatta ctcgctcgcc ttcggcttcg ccacggatgc catgatggac gcgacgggcc
    16021 tgcacgccgc gtaccgcgcg gccaccggct gttccctcta cacggtcgag gcccacctgc
    16081 ggtatctgcg cgacgtcgcc gaaggcgccc acctcgcggt acgcacccgg gtgctcggtg
    16141 tgcacggcaa gaaggcgcac ttcgcgcatg agctgtacgt cgtcgacggc gccgcggccg
    16201 atccggcgcc ggacgccggg ccggtggcga cgacggagct gctggccctg cacgtggacc
    16261 aggaactggg gcgtgcggtg gcgttcccgg acgcggtgct cgagcgcttc gccgagttcg
    16321 tggaaccggc gccggaatgg gcgggccgcg cgatcgcggc agtggtcgcc gctaaataga
    16381 gcgttcgttc tagaccgggg cggcgtctgg agccggtccc gcgccggtct ggtccagggc
    16441 ccgctccggg cacctcgtgt ttcgcatggc atcgtgcgca gtggtaggtg ttcggagcga
    16501 tgttcaacag ttcactgttc actgagactg cgggcaaggt ggttcagacg tgaggctggc
    16561 aattctgggc ggcggcggat tccgggtgcc cctcgtgtac cgggcgctgc tcggcgaccg
    16621 cgccgagggc cggatcaccg aggtcgtcct gcacgacgtg gacggcgccc gggccggggc
    16681 gatcgcccgt gtgctcgccg accaggccga cggggtgccc gccgcgcccg ccgtgcgcgt
    16741 caccaccgac ctcgacgacg cgctgcgcgg cgccgacttc gtgttctccg cgatccgcgt
    16801 cggcggtctg gaaggccgtg ccgccgacga gcgggtggcg ctcgccgaag gggtgctcgg
    16861 acaggagacg gtcggcgcgg gcggcatcgc gtacgggctg cggaccgtgc ccgtcgccgt
    16921 cgacatcgcc cgccgggtgc ggcggctcgc gcccgaggcg tgggtcatca acttcaccaa
    16981 ccccgcgggc ctggtgaccg aggcgatggc ccgccacctc ggcgaccgcg tcatcggcat
    17041 ctgcgactcg cccgtgggcc tcggccgccg ggtggcgacg ctgctcggcg ccgagcccgg
    17101 ccgggcctgg ctcgactatg tgggcctcaa ccacctgggc tggctgaccg gcctggaggt
    17161 cgacgggcag gacctgctgc cgcggctgct cggcgaccgg gacctgctcg actccttcga
    17221 ggagggcaag ctcttcggcg ccgactggct ccagtcgctc ggcgcgatcc ccaacgagta
    17281 cctgcactac tactacttca accgggagac cgtccacgcc taccggacgg ccgagcggac
    17341 ccgcggcgcg ttcctgcgcg accagcaggc ccgcttctac gacgaactgc gcaaccccga
    17401 ggccgccgcc ttcaagacgt gggacgccac ccgcgccgag cgcgaggcga cgtacatggc
    17461 gcacagccgg gaggccgcgg gtgccgggga acgcgccccc gaggacatgg agtccggcgg
    17521 ctacgaacgg gtcgccctcg ccctgatgcg ggccatcgcc cgcgacgaac gggccacgct
    17581 gatcctcaac gtccgcaacc gcacgaccct gcccgagctc gactcggacg cgatcatcga
    17641 agtgccgtgc ctggtggacg cgtccggccc gcacccggcc gccgtgtcgc cgctgccggg
    17701 gcacgccacg ggcctggtgt gcgcggtcaa ggcggtcgag cgcgaggtgc tcgccgcggc
    17761 ggacagcggc tcgcgcgcca cggcggtcaa ggcgttcgcg ctgcacccgc tggtcgactc
    17821 ggtgtccgtg gcccggcgcc tggtcgacgg ctaccggcag gcgcacccgg ggctggccta
    17881 cctgacgtga tcaccaccct ggcatgatca tgaaatgacc gcgcccgagc cccgcagtac
    17941 gcccgagccc cgcaccgcgc ccgccgtgcc cctgcccgaa ccccgcaccg cccccgacgc
    18001 tgtgtccccg gcggccccga cagtcccggc ggccccgaca gccccacccg ccacccgtcc
    18061 ctgcacgctc gtcgtgtgcc ggggctgctg ctgcggcgac ccggtcaagc accccggcac
    18121 ggaccacgtg ggccagttgg cgcggctgcg cgcggcggcg gaccgttccg ggggccggtt
    18181 cgcggtgcgc accagcgagt gcctcggccc ctgcgggcag gccaacatcg tggtcgtcca
    18241 gccctcccgc gcgggccgcg cgcacggtgg ccgtccggcc tgggtgggct tcgccctcga
    18301 cgacgcctct ctcgacgaca tcctcacctg ggccgaggcc ggcggccccg gcctcgcgga
    18361 gccgccggac gcgctgacgc tgcaactggt cgatccccgg caggtctagg cgcgagcgag
    18421 cacctggtcc aggaagccgg tgaggttgcg cacggtgcgc tcgttctgct cctccggggt
    18481 gaggctctcg tcgaagcggc gggccagggc cgaggtcttc ttgccgcgta cgtagaggga
    18541 gcaggccagg tccgcgcaga cgtacaggcc gacggagttg ccctggcggc ccgcctcgcc
    18601 cgcgcggggc gcgacgagca gcgcgatgcc cgaacccgcc tgcggcgtca cgcacaccga
    18661 gcagatgctg gacttcagca tggagcggcg ggcccccgtg gaggcgcgca gggcgatgcc
    18721 gaccagctcg tcgccccgct cggccacgac atagccgcgg tccggggcct tggggtcgcg
    18781 ccagcccagg aagtccaggt cggaccaggg cgtctcggcg aagcccgcgg gcagcgtcag
    18841 gcgccgggcc tcgcccttcg agcagttcac gaacgacgca cggatttctt tgtcaccaag
    18901 ggcacgcatg gttcggaagg tatcaatccg aacgcatggc cgtcttttca tttttgccgg
    18961 tcagggccct gcgcccggcc tcggatgccg ctgttgtccg tgccgcgcgg aacgagatgt
    19021 tccgccgcag tcggaacccc agcgactcgt acagccggac cgcccccgtg ttgcgcgccg
    19081 ccgtgtgcag gaacggaatc tcgccgcgct ccctgatgcc gtacgccacc gcgaggacca
    19141 ggcggctcgc gaggccgtga ccccggtacg cggggtcggt gcagaccgcg ctgatctccg
    19201 tccagcccgg cgggtgcagc cgctccccgg ccatcgcgac cagggcgccc tcgtgacgta
    19261 tgcccagata cgttccgagt tctatggtgc gctcccggaa cgggcccggc cgcgtgcgcg
    19321 ccaccaggtc cagcatctcc ggtacgtctt cgggcccgag ccgcaccgtc ccggcgtccg
    19381 gcgccgccgg gatgtcgccg tcgacgagct gcaccccggc cacgtcgaac gtcacctccc
    19441 agccggccgg cacgtccacc gcgacaccgg gcagcggcac ctcgccgtcc ggtcccgcga
    19501 aggcggcaag gtccgcccag tccgccgcgt ccggcgcggt gggcatcccc agccagggcg
    19561 acacggcgtc cggatagcgc gcgacgcgcc cgcgccgctc ggcgaagtgc gcgtgcgggc
    19621 cttcgaggga ggcgagtccg gggttgtcga gggggtgcgg ggtccccgcg gcggcgggcg
    19681 acgccgacgt accccgctcc accgcccccg gcgccctcac gcgccgacct cgatcacgac
    19741 cttgcccagc gcgtgcccgg tctcgacggc gcgcagcgcc tcgcccgccc ggtcgagcgg
    19801 gtacgtcgcc gtgatgtgcg gccggagcac cccggcggcg gcgagttcgg ccaccgcgtc
    19861 gagcgtggcg gcgtcgcgcg cccgggccac ggcggagccg cccagctcgc ccacgatctg
    19921 cttcccgccg gccgtgatca gcttcgtgcg gtcggccacc acgtccgcca cggcccgcag
    19981 atggtccccg ccgaccaggt cgaagacgcc gtcgacgccg tccggcgccg ccgcgcggat
    20041 ccgctccacc aggtccggtc ctgacgccac atgggccgcg cccagcgact cgacgacgtc
    20101 cttcttgccc tcgctcgcgg tgccgatcac gcgcagcccc aggtggcgcg cgaggcgcac
    20161 cacgttcccg cccacgccgc caccggcgcc cgtgaccagc agcgtcgccc cggcgggcag
    20221 cgcgagttgg cgcaccccgt cgtaggcggt ggccgcggcg accggcagtg tcgcggcctc
    20281 cgcgaacgac aggccctccg gctggtgcgc ggcgatcgcc acgggcagca gcgtgtactc
    20341 ggcgtacccg ccggtgagcg tggacccgaa caccgcgtcc cccacggcga aaccctcgac
    20401 gccaggaccg gtccgcgcca ccacgcccgc ggcctcgctg ccgagcacct cgggcagtgc
    20461 ggcgggcgcc tgccccggcc tgcggtaacc gccgcgcagc ttgtagtcga cggggttgac
    20521 gcccgccgcc cgcaccgcga tcagcaactg acccgggccg ggctcgggcg gctcccggtc
    20581 gacgagggcc tccacctcgg ggccaccgtg ccgggtgaat acgtacgcct tggccatctg
    20641 tccctcgctc cgctccctgc gccccgcgcg ccccgtggcg cccggcgcat cccaacgatc
    20701 acagatgaca aggcggggcg ccgtgcccgc attcctggcc ggcggagagt tcacgagccc
    20761 gcaacgcgga accaccgacc actccggcac ccgcggttgt ccccgccgtc acctccgcga
    20821 cacggcaccg cccgcctctt ccataagcct tggtgcactt gacacacttc acccgctcac
    20881 gtccccccac ttcacgcgag gtcatatccc catgcctgga ctgaaccggc gccgcttcat
    20941 gcaactggcc ggtggcaccg ctgccttcgc cgcgctgaac gagagcatcg cccgcgcggc
    21001 ctcgctgccc gcgaagcgcc gcaccggcac catcgaggac gtcgagcacg tcgtggtgct
    21061 catgcaggag aatcgttcct ttgaccacta tttcgggacg atgaagggcg tacgcggctt
    21121 cggcgacccg cgcccggtga cgctgcccag cggcaagccc gtctggcacc agcagggcgg
    21181 cggcaaggag gtgctgccct tccacccgga cgccgacgac ctcggcatgc agttcatcgc
    21241 gggcctcgac cacgactggg cgggcggcca cagcgccttc ggcgacggca ggtacgacaa
    21301 ctggatcccc gcgaagtccg agcggaccat ggcgtacctg gaacgggacg acatcccgtt
    21361 ccactacgcg ctcgccgacg ccttcacggt ctgcgacgac taccactgct cgttcatggg
    21421 agccaccgac cccaaccgct actacatgct gacgggccac gtcggcaacg acggcaaggg
    21481 cggcggcccg gtcctcggca accaggaggc gggctacgac tggacgacgt acgccgagcg
    21541 cctggagcag gcgggtgtct cctggaaggt gtaccaggac atcggcgacg gcctggacgc
    21601 ggccgggcac tggggctgga tcgacgacgc gtaccgcggc aactacggcg acaactcgct
    21661 gctgtacttc aacaagtacc gcaacgccaa ggccggcgac ccgctctacg acaaggcccg
    21721 caccggcacc aacgccaagg cgggcgacgg ctacttcgac atcctgaggg ccgacgtgaa
    21781 ggcggaccgg ctgccgcagg tgtcctacat cgccgcgccc gaggcgttct gcgagcaccc
    21841 caactggccg gtgaactacg gcgcctggta catcgcgcag atcctcgacg cgctcacctc
    21901 caacccggcg gtgtgggcga agacggcgct gttcctcacg tacgacgaga acgacggcta
    21961 cttcgaccac gtcgtgccgc cgtacgtccc ctcctcggcg aaccagggcc tgtccacggt
    22021 cgacaccaag ctcgactact tccccggcaa cgcctcgtac ggcgccgggc actacggcct
    22081 cggccagcgc gtcccgatga tcgtggtgtc gccgtggagc accggcgggt tcgtgaactc
    22141 cgaggtcttc gaccacacgt cgatcatccg gttcatggag aagcgcttcg gcgtccagga
    22201 gcccaacatc tcgccgt
//
