LOCUS       NZ_BMVR01000004        22187 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000004
VERSION     NZ_BMVR01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 715038)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 572766
            Orig. end                         :: 594953
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22187
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22187
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22187
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12187](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12187
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            54..392
                     /locus_tag="IE274_RS12840"
                     /old_locus_tag="GCM10010349_26180"
     CDS             54..392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523706.1"
                     /locus_tag="IE274_RS12840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26180"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_190115784.1"
                     /transl_table=11
                     /translation="MANELMRWESDEGPVVVEVDSRDPGYKSVSRRDGNGEIHDVEGRF
                     ESALDNVRGAALSALRTFRTQALNPDEISLEFGVKLSAAAGAVIAKTAAEGHLTVKLTW
                     SREGAQGE"
     gene            401..2191
                     /locus_tag="IE274_RS12845"
                     /old_locus_tag="GCM10010349_26190"
     CDS             401..2191
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039783.4"
                     /locus_tag="IE274_RS12845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26190"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_190115785.1"
                     /transl_table=11
                     /translation="MHWRARIGTVGGGAPLGAGVLVDSTRLITCAHVVDGLREVRVTLP
                     GCADGLRATVSWSGDWRRQDDPGDVAVLTLDDPLRVPPCVFAPLGSLRPRKGRTAYELR
                     ALGFPRGHEEIGTHVTLRTSEDRQLGSEWLEMDVEQAHLQRLDEGFSGAAVYDIESRQV
                     VGIVTDAVLAGDQEGYLGRMLSLDVIRRHWEALDDLLPLDWLPPAPRHELRALFEDVQV
                     EARTLEVAVRRAFPTLRRDPPHLRSGWQAVRYVAETLTGDDRLTRLLRELGQWSPGGIG
                     PGIAAWMRRWMPGEGEYAGAGVLGGELYGGLQGGWGGGGRAEACAPTGSVMFRAEPMTR
                     GGSLELSVCTVVDGVPVGRAGPVRIRRQQLRARVEALLAEQVGRIHEFDWMLEFVVPPG
                     LMSEPYEEWHIREPGAARPRPMRTVPVVVRHVERLKPLTVSRLTRKRWQTVRARGETRP
                     VPVECGLPYGYEQFYGWLDADDDLCALAYAARPVDDWLSAALDTGVPIMLWRRHDCGGD
                     GHAHCAPKAFLDRLADAVATLEPDRLPLEVMKLRKAAHSPHKGDADHCGHRLTLFWDDP
                     ERMPDPPLAMGNPMGSRGSA"
     gene            2193..3437
                     /locus_tag="IE274_RS12850"
                     /old_locus_tag="GCM10010349_26200"
     CDS             2193..3437
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976356.1"
                     /locus_tag="IE274_RS12850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26200"
                     /product="MoxR family ATPase"
                     /protein_id="WP_190115786.1"
                     /transl_table=11
                     /translation="MPPSENAPPPEVPPPGRRSSEVPRPETPSSASSGAWSSDAPPSKS
                     PSPTGPAPAPPPASWQIYSGSRTPHDGITRLPAPPPWRTFKGGPPLPTPPGDSGNQHAA
                     VSYRPSADAVRQVNAALYLRRPLLVTGAPGTGKSSLAYAVAHELGLGKVLHWPITSRVT
                     LRDGLYAYDPLTRLYAAERARHDGTRGDASQGCAGQGPAGDGPVGDDIGDYLRLGPLGT
                     ALLPFARPRVLLVDEIDKSDIDLPNDLLTIFEKGSYELVELARRAAPTARVMTADSTKD
                     RVEIRDGTVTCRAFPLVVMTSNGEREFPPAFLRRCVTVDLKQPATLDELTAIVREHLGP
                     VVGDGTGVLPVGVQDVIQRFFDRRSGGLLANDQLLNAIYMCHHAAFTEPPESVARLADQ
                     VMPFLTAEAARSDDA"
     gene            3427..7788
                     /locus_tag="IE274_RS40050"
                     /old_locus_tag="GCM10010349_26210"
     CDS             3427..7788
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041121.1"
                     /locus_tag="IE274_RS40050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26210"
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_190115787.1"
                     /transl_table=11
                     /translation="MTLDRLRDLLAALGPPVTPLDLAEMVWLAERLPPGEAEGEGTAGG
                     GPPAPLGEGSGPGGARTPGLSGGHAPAAGGVEGAGESGGSGDATGGSPGHDGHDGHDAP
                     GPARAGADAPADGAPGPARTALHLPRGPARPGTDADDVLVPAPQALRHELAIQRALRPL
                     KQRVPDRRRRVLDEAATAARAAEHPGSLPWAPVLVPATDRLFSLALVVDTGPAMSVWRP
                     LVRELREAVQRTGAFRDVRVWRLADLGKRVGVRSSSRGPALTPAAVVDPTGRQIVLVLS
                     DCSGPHWWGGRAGPALHLWAGRGPTALLQPLPERLWRRTAAPAVPGRAIAPRAGAPNTA
                     LRFTPHDGHARRPAGTVPVPVLELAPEWLADWAGLLMAAGDHHRDTAVTYVGPDARPQD
                     QPLADEGDLPITERILRFHSAASPTAADLAAHVALSVPALPVMRLIQQRVTPGSRPSDL
                     AEVLLSGLLEPVDPARGLYDFVPGARSALLQTLPRPESLAVAELLGRIGAEIEARAGSA
                     TSAFRAVVAVAQGAGSRGLGVAGEPFALVSEEALGVLRGRAIPVVERPVEVAGESAVVP
                     PAPAVPAVANVPTRGRSFVGRTSELQRLEADFSGTGDSADRLRVVVVHGMAGVGKTELA
                     AEWVRSRPGGSRWWVRADSREEIDEGLHVMGRALNPAVVPALPRSAGIEWTVRWLASHA
                     DWVLVLDDVRDSSEVRELLARLDSGGRVLVTTRNTAGWGSMLHEGLDVALKSLPLSALQ
                     LPEAVELLRTRAGAGAVLDGAAALCEELDCHPAAVVRAAADIARTGMSVAEYRTLIGRR
                     PGHEETSLLPRVVRASKDPLAARLLNMLAWLAPDPVPRSVVSRMAGVRELGSALRLLEG
                     LDLVSVDDEVIRVRPGVQSAVRTADDSTPLRSREAVAWARAEAAVCLANTLPRDPNAVY
                     AWPRWREVLPHVLALAEHVRPEDDSAPLASSLSLAAGYVLAQGQPDRAVGMLERAVESL
                     RRISGADAPETLAAAGQLAGAYRAAGDVRRAIALYESTVLTLGRALGAGRSETLELRLE
                     LAATYLELGSVPEARQQFDAVLQLSRGWHPQFVRHALTARAGLADTLLEDDAQDALSVY
                     EDILAECRRMLGDEHPHTIYVRGKLSAAAHRAGDDARARSAAESTLAACRHVFGHDHLR
                     TIRAMGDLAYVYEGSERLRPRAIEAYEEAVGHSTVVRGASHPGTLALRDRLAALYARDE
                     NWQRAIAQYAKLLAVRAAELGEDHPGTLRTVAHLAEAHSCAGSWRRAIALHERVLDAQI
                     RSLGDGHADTWPSYDRLAEAQRGVGNVPEALRLYKRVLDFRTAALGRQHPDTVTTLEAM
                     ARVHLDADHLDLALDAYAQALELRRGAQGELHPDTLAAVRRVAWLYAEAGDTESAVVTY
                     RTTVNHCAAVGDVWQAVALLEWAGQHVAPALGADHPESLRIREELDHLRRR"
     gene            complement(7834..8616)
                     /locus_tag="IE274_RS12860"
                     /old_locus_tag="GCM10010349_26220"
     CDS             complement(7834..8616)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328701.1"
                     /locus_tag="IE274_RS12860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26220"
                     /product="aldo/keto reductase"
                     /protein_id="WP_190115932.1"
                     /transl_table=11
                     /translation="MPQLGFGVWQVPDDEAERAVATALESGYRSIDTAALYENEVGTGK
                     GIAASGIDRDQLFVTTKLMSTDQGYDRALRAFDASLERLGLDYVDLYLIHWPVPSEDRY
                     IDTYKAFEKIHADGRAKSIGVSNFLPEHLERLIDATSVIPAVNQIELHPHLQQRASRAY
                     HAEQGIATEGWSPLGQGKGLLEVPAIVAIAQKHGRSPAQIVLRWHIQLGNVAIPKSVTP
                     ARIKENINVFDFELDPEDMAAISALNEDRRLGPDPAEM"
     misc_feature    8770..8790
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.39"
                     /tool="antismash"
     misc_feature    8887..8907
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            8943..9083
                     /gene="pqqA"
                     /locus_tag="IE274_RS12865"
                     /old_locus_tag="GCM10010349_26230"
     CDS             8943..9083
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_157882578.1"
                     /locus_tag="IE274_RS12865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26230"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_190115788.1"
                     /transl_table=11
                     /translation="MNTHEMETSEVTSVSPETGPATGWQTPEYTIVETSLEVTAYRLAD
                     R"
     gene            9093..10004
                     /locus_tag="IE274_RS12870"
                     /old_locus_tag="GCM10010349_26240"
     CDS             9093..10004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="IE274_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26240"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_190115789.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGLPQWNCACPGCAGARAHPERRRLHASLALRAS
                     PGRWYLINATPDIGEQIEACPELLPAPGPAADTRLSPLAGVVLTDAELDHTLGIARLRE
                     ARDGVDVLATAPVLDAVRDRLGLGAVLDPYTRTRWRELTGARQQLNDHSAVRVDAVRVS
                     AKRPRYAAGLGPDDAAWSVALRLHDTGTGRTVLYAPALAAWTDAFEEAAREADVVLVDG
                     TFWGEEEPRRAGFSDRTATGMGHLPIAGPGGTAHRLAGLPGRCLYTHLNNTNPLGDPDA
                     EQHKQLADWGLEVARDRMVIEL"
     gene            10001..10774
                     /gene="pqqC"
                     /locus_tag="IE274_RS12875"
                     /old_locus_tag="GCM10010349_26250"
     CDS             10001..10774
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645345.1"
                     /locus_tag="IE274_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26250"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_190115790.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.4e-85, bitscore:
                     281.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATVKTAADSAAGADDAPWTPDELTERLRAVSAARYHDRHPFNV
                     RMHEGTLTRAELRRWIANRFHYQRHIPIKDALILAKFDDPALRRGWSRRIRDHDGDRPG
                     EGGIERWLRLGEAAGLARAELLDTSRVLPGVRLAVDGYVNFCRLRPALDAVAASLTELS
                     APDLMRTRIAAFEQHYPWIDTEGLSYFRGRVGQGGRDGQEALGLVRAWARTRAEQERAV
                     AALGFKCDVLWALLDAVDGASGRDGQGAGDGGGHA"
     gene            10767..11096
                     /gene="pqqD"
                     /locus_tag="IE274_RS12880"
                     /old_locus_tag="GCM10010349_26260"
     CDS             10767..11096
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712684.1"
                     /locus_tag="IE274_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26260"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_190115791.1"
                     /sec_met_domain="PqqD_RRE (E-value: 4e-17, bitscore: 57.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-07, bitscore: 26.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREAVAGERPSGAAGPNAAEDELVRPDWRPVLARSVVLRRDRVRG
                     ADLLLLPERVVVLRGAAAAIVALCDGERDVAGIVAELRRRHPGAPVGDEVPVFLGRLRA
                     ERWLR"
     aSDomain        10836..11090
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IE274_RS12880_PqqD_RRE.1"
                     /evalue="1.90E-18"
                     /identifier="RREFam006.1"
                     /label="IE274_RS12880"
                     /locus_tag="IE274_RS12880"
                     /protein_end="108"
                     /protein_start="23"
                     /score="57.0"
                     /tool="antismash"
                     /translation="VRPDWRPVLARSVVLRRDRVRGADLLLLPERVVVLRGAAAAIVAL
                     CDGERDVAGIVAELRRRHPGAPVGDEVPVFLGRLRAERWL"
     gene            11093..12187
                     /gene="pqqE"
                     /locus_tag="IE274_RS12885"
                     /old_locus_tag="GCM10010349_26270"
     CDS             11093..12187
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="IE274_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26270"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_190115792.1"
                     /sec_met_domain="PF04055 (E-value: 8.6e-23, bitscore: 76.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.8e-08, bitscore: 27.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 8.4e-08, bitscore: 27.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.1e-11, bitscore:
                     37.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVAPEPPWALLAELTHGCPLRCAYCSNPVKLNSRSEELTGDEWG
                     DVLRQAADLGVVQTHLSGGEPLLRRDLRDIVAAADAAGIHTQLVTSGVGLHEARLAGLV
                     DAGLRSVQLSVQHADPARADLIAGARATGAKERAARLVREAGLPLGLNAVLHRANLDAL
                     DALVELGLDWGADRIELANTQFYGWALRNRDALLPDPDQVDRARGTLERWRARLGGRME
                     LVWVAPDYVDATAKPCMGGWGAVSLTVAPDGTVLPCPAAAELLGADAPNVRDRPLDWIW
                     RESPAFTRYRGEGWMREPCRSCELRTVDFGGCRCQAHALTGDAARTDPACHRSPDHGVV
                     RALVEAARGPAPDHPGYAYREGGT"
     gene            12184..13485
                     /locus_tag="IE274_RS12890"
                     /old_locus_tag="GCM10010349_26280"
     CDS             12184..13485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645348.1"
                     /locus_tag="IE274_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26280"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_229909517.1"
                     /transl_table=11
                     /translation="MMRRHRSPTSPISTPLQSAPPKPPAPPTGPRGKAARAVLAALLAG
                     CAALTAQTAPAAAEGPPAADRTPAPDRTHAAQPRGTDWSRALVDSTTTRFTPTSIGGWS
                     YPVGLYLFGQYGTYQRTHDARYLTYIKSYVDRFVDGDGNIGQKFNSLDSMQAGRLLVIL
                     HHETGEDRYRVAARKIRDRLKSYPRTGDGGFWHADTDSRAHQLWSDGVYMVTPFLVEYG
                     KEFGDEAYTDREAVEQLNVYARHLQADNGLFQHAYDESRTASWADKDTGRAPEQWCRAI
                     GWYSMAAVDVLDATPRSDPGRGELLGHVRKLAGGIAKAQDPATGRWFQVVNKGTQEGNW
                     TETSCSSMFTFALSRAAEKGYVAPSYQGVARRGYEGVLKKISLGADGLTNLTDISIGTN
                     VGDYAFYIARPRQTNDFHGLGAFLIMNEQLRKQR"
     gene            13493..14287
                     /locus_tag="IE274_RS12895"
                     /old_locus_tag="GCM10010349_26290"
     CDS             13493..14287
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482488.1"
                     /locus_tag="IE274_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26290"
                     /product="heparin lyase I family protein"
                     /protein_id="WP_190115793.1"
                     /transl_table=11
                     /translation="MTPSRRALFAAALGTGAGVAATAVGLSPAAAAPTADWQLRWSPSA
                     RDVGLRAFETLEDDRANSHPAAKPHIFAEGDNFRFTMHTVDRDTSDDRQRHEVTGLRTG
                     NSFLTWQRGQTWRVTYRMFLPSTLKATTSFTHIMQMKQPGAGSAPIVVQSLRRVDGKQT
                     IELKIFDDDILIGRTDLAPLHDKWTDVDFQIKIGDGSSGSVRWILKSGGTTVIDKSKTG
                     IDTFLADRVRPKWGIYRSLGDTSGSLQNTYMLLTGMRGYQLV"
     gene            14325..15356
                     /locus_tag="IE274_RS12900"
                     /old_locus_tag="GCM10010349_26300"
     CDS             14325..15356
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059075.1"
                     /locus_tag="IE274_RS12900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26300"
                     /product="chitinase"
                     /protein_id="WP_190115794.1"
                     /transl_table=11
                     /translation="MRRLTSLSGLALAAAALLGLSQLPAAADSAGTGAADAGAAKTAAP
                     KAAGTIHAAPYEYLGWGSPQKPTDVMAATGVKWFTLAFILSDGGCNPAWDGSRPLKGGS
                     DESAIKSIRAAGGDIVVSVGGWSGAKLGEKCSSATALAAAYQKVIDAYKLKAFDVDIEN
                     TEFNNPTVRQRVVDALKIVEQKNPGIVTYVTLGTTPNGPDATGKDLIQRGARAGLAADA
                     WVIMPFDFDGHSGTMGEASVSALEGLKNTVRSAYGYSDTDAYRHIGVSSMNGRTDVAGE
                     TVTTADFKKILGYAQQHHIARFAFWSVNRDRSCAGGGSAGDSCSGIGQQPYEFTKIVAQ
                     YGG"
     gene            15413..16519
                     /locus_tag="IE274_RS12905"
                     /old_locus_tag="GCM10010349_26310"
     CDS             15413..16519
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433956.1"
                     /locus_tag="IE274_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26310"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_190115795.1"
                     /transl_table=11
                     /translation="MHGNTRNTGLARKVALAAATALAAGVVAYVPSVSAAPAAPAGEPT
                     DIKTVSTGWTIPWGTSWLPDGKSALVTERDDFRVWSISADGATKKQVGTVPESQTTGGE
                     GGLMGVAVDPQWATNHYVYVMHTSSEGNRVARMTYDGSSLSGYTVLLKGIKKARYHNGG
                     RLAFGPDGYLYATTGDAQDRPLAQDKNSLNGKILRMTRDGKPAPGNPFGNYVYSLGHRN
                     PQGIAFDPQGRLWEAELGDATKDELNLIKPGKNYGWPTCEGNCNVAGMTNPKKTWGVAE
                     ASPSGVAIVDGAVYMAALKGQRMWRIPINADNENVGTAKAFYVGQYGRLRAVTTVPGAK
                     ALWLSTTNADGNGGQPDGADKILRVTIG"
     gene            16674..18245
                     /locus_tag="IE274_RS12910"
                     /old_locus_tag="GCM10010349_26320"
     CDS             16674..18245
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058227.1"
                     /locus_tag="IE274_RS12910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26320"
                     /product="glycoside hydrolase family 28 protein"
                     /protein_id="WP_190115796.1"
                     /transl_table=11
                     /translation="MSRSRTRTGALAAGLAALAVLAVFDGPSAGAVRVRAEAATAARAP
                     APQRPLPAAEFNVRDYGAKGDGSTNDTPAIQRAVNAANSAGGGTVRLPGGGSTYESKNT
                     LHMKSDVTLQVDKGATLSGNGADDYDPPEPNEWDDYQDYGHSHFHNAMIHGDRLSNIAF
                     VGEGVIDGDGALITGNPESGEADKIISLTRCKGLRLGDGLTLREGGHFAALVNGCDDVV
                     SDRLTIDTAMDRDGWNVINTTDVTVTGAHLDANDDALAFKSDYALGAKLPNGRVRVSDS
                     YLSAGCCNALMFGSETCGDFTDYRFERIRIEGSDKSGLGMVSMDGSRISDVHYKDITMT
                     GVRSPIMQKIGNRKRCGNNPGVGSISDITYTNVKATGSTPSFSPTLWGESGQSRIKDVT
                     FTNVDLTVPGGNGTMSTDVPSNKSTDYNPKSIGTRPGYGWYIRRADDVTFIDSEVRFAS
                     DDGRPAVVANDSTGIRFSTFTAQRGSASPADLVFQQTRGYCVRDSANTGGGVLRVGQSG
                     SSEDCG"
     gene            complement(18284..20107)
                     /locus_tag="IE274_RS12915"
                     /old_locus_tag="GCM10010349_26330"
     CDS             complement(18284..20107)
                     /NRPS_PKS="Domain: AMP-binding (25-476). E-value: 1.7e-90.
                     Score: 295.4. Matches aSDomain:
                     nrpspksdomains_IE274_RS12915_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676059.1"
                     /locus_tag="IE274_RS12915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26330"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_190115797.1"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-88, bitscore:
                     292.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREFTNPPMASAPRVGGLADAVFDHALEDPVRVVLGRKHDGVWQD
                     VTSAEFRDEVLALAKGLLAQGVRFGDRVAIMCRTRYEWTLFDFALWTVGAQVVPVYPTS
                     SAEQVFWMLHDAQVSAAMVEHEDHAMTIGSVVDRLPQLRRLWQLDGDAVRELTEAGRDL
                     DDEVVHRHRRAVTPDSVATVIYTSGTTGRPKGCVLTHANFMFEVDTLIERWEPVFRSKR
                     GDEPSTLLFLPLAHVFGRMVQIAAVRARVKFGHQPSLNAAALIPDFATFRPTFILAVPY
                     IFEKVFNAARRKADRDGKAGPFDKAVEAAVRYADAMEAKAFGTGPGPSTALRMQHQVFD
                     KLVYAKVRDAMGGRVRHAMSGGSAMDRRLGLFFAGAGVQVFEGYGLTESTAAATANPPE
                     RTRYGTVGQAIPGTTVHIAEDGEVWLRGGHVFQGYLNDPKATDATLHDGWLATGDLGAL
                     DDDGYLTITGRKKEILVTSGGKSVSPAQLEERVRDHPLVAQCIVVGNDRPYIAALVTLD
                     AEAVEHWLSMRNKPPLPPGDLVRDPDLETEVRRAVVAANTLVSQAESIRTFRILAHQFS
                     EEHGLLTPSLKLKRKAIEQAYADEVEALYHS"
     aSDomain        complement(18680..20032)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS12915_AMP-binding.1"
                     /evalue="1.70E-90"
                     /label="IE274_RS12915_AMP-binding.1"
                     /locus_tag="IE274_RS12915"
                     /protein_end="476"
                     /protein_start="25"
                     /score="295.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALEDPVRVVLGRKHDGVWQDVTSAEFRDEVLALAKGLLAQGVRFG
                     DRVAIMCRTRYEWTLFDFALWTVGAQVVPVYPTSSAEQVFWMLHDAQVSAAMVEHEDHA
                     MTIGSVVDRLPQLRRLWQLDGDAVRELTEAGRDLDDEVVHRHRRAVTPDSVATVIYTSG
                     TTGRPKGCVLTHANFMFEVDTLIERWEPVFRSKRGDEPSTLLFLPLAHVFGRMVQIAAV
                     RARVKFGHQPSLNAAALIPDFATFRPTFILAVPYIFEKVFNAARRKADRDGKAGPFDKA
                     VEAAVRYADAMEAKAFGTGPGPSTALRMQHQVFDKLVYAKVRDAMGGRVRHAMSGGSAM
                     DRRLGLFFAGAGVQVFEGYGLTESTAAATANPPERTRYGTVGQAIPGTTVHIAEDGEVW
                     LRGGHVFQGYLNDPKATDATLHDGWLATGDLGALDDDGYLTITGRKKEILVT"
     CDS_motif       complement(18779..18847)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS12915_0003"
                     /evalue="5.00E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS12915"
                     /protein_end="443"
                     /protein_start="420"
                     /score="18.9"
                     /tool="antismash"
                     /translation="GEVWLRGGHVFQGYLNDPKATDA"
     CDS_motif       complement(18932..18982)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS12915_0002"
                     /evalue="2.30E+01"
                     /label="NRPS-A_a6"
                     /locus_tag="IE274_RS12915"
                     /protein_end="392"
                     /protein_start="375"
                     /score="-2.3"
                     /tool="antismash"
                     /translation="AGVQVFEGYGLTESTAA"
     CDS_motif       complement(19508..19567)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IE274_RS12915_0001"
                     /evalue="6.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="IE274_RS12915"
                     /protein_end="200"
                     /protein_start="180"
                     /score="28.0"
                     /tool="antismash"
                     /translation="ATVIYTSGTTGRPKGCVLTH"
     gene            complement(20312..21835)
                     /locus_tag="IE274_RS12920"
                     /old_locus_tag="GCM10010349_26340"
     CDS             complement(20312..21835)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571779.1"
                     /locus_tag="IE274_RS12920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_26340"
                     /product="MFS transporter"
                     /protein_id="WP_190115798.1"
                     /transl_table=11
                     /translation="MRTWGPLTAVCLGTFMLLLDVTIVVVALPDMARALDASLSDLQWV
                     IDGYALALAALLLGVGAAADVLGRRRIQVAGTVVFALASLGCGLASNAEVLVAARAVQG
                     LGAAAMFATTLPLLGAAYQGKQRSVALGVWGAVSGGAAALGPIVGGLLTEGPGWRWIFF
                     VNLPVSVAAVWLTLRLVPESAQTAHSAQSKGPAARRVDWAGTVTFALFAGALIFGAVRA
                     STVGWTSARTGATFLVAMLALVAFVVVERRAAHPLIDLRLLRKPAFTGVLLGAIGYNAA
                     AFGVIPYLSIWLQTVLGMSPVRGSLVLLPLAATSFVVAAVGGRLLHGAPARYVIGVGLL
                     LIGAGCLAMAVLDADSSWGALVPGLTLAGIGTGLVSPGLAGAALAALPPENAGMAGGAV
                     NTFRQLGYALGVALFGTVLTSRMQDSIGQEAAHTAAGGGASALEGTVSAHSVREAFAAG
                     LNGASLTAGAVGVAAGLAVLLMVRTKPARVAGQTPSAVSEPTPEKQLQG"
     misc_feature    complement(22146..22160)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
ORIGIN
        1 gttgagggat cgtggaggga agggaacggg acacctgacc caggggggcg tgcatggcga
       61 acgagttgat gcggtgggag tcggacgagg ggccggtcgt cgtggaggtg gactccaggg
      121 acccggggta caagtccgtg tcgcggcggg acggcaacgg tgagatccac gacgtggagg
      181 gcagattcga gtcggcgctc gacaacgtgc gcggcgcggc cctctccgcc ctgcgcactt
      241 tccgtacgca ggccctcaac cccgatgaga tctcactgga gttcggggtg aagctcagtg
      301 ccgccgcggg tgccgtcatc gcgaagaccg cggccgaggg gcacttgacc gtgaaactga
      361 cctggtcccg cgagggtgcg caaggcgaat aatggcggac atgcactggc gtgcccgcat
      421 cggcaccgtc ggcggcggtg ctccgctggg ggcgggcgtg ctcgtcgaca gcacccggct
      481 gatcacctgc gcccacgtcg tcgacggcct gcgtgaagtc cgtgtgacgc tgcccgggtg
      541 cgccgacggg ctgcgggcca ccgtgtcctg gtccggcgac tggcggcgac aagacgatcc
      601 cggcgacgtc gcggtactca ccctcgacga ccccctgcgc gtaccgccgt gcgtgttcgc
      661 cccgctcggg tcgctgcggc cccggaaggg ccgcaccgcg tacgaactgc gcgccctcgg
      721 cttcccccgc ggccacgagg agatcggcac ccacgtcacg ctgcgcacca gcgaggaccg
      781 ccaactcggc agcgaatggc tggagatgga cgtcgagcag gcccacctcc agcggctcga
      841 cgaggggttc agcggtgccg ccgtgtacga catcgagtcc cgccaggtcg tcggcatcgt
      901 caccgacgcc gtactcgccg gtgaccagga gggctacctc ggccggatgc tctccctgga
      961 cgtcatccgc cgccactggg aggccctgga cgacctgctg cccctcgact ggctgccgcc
     1021 cgcaccgcgc catgaactcc gcgccctgtt cgaggacgtg caagtcgagg cgcggaccct
     1081 ggaggtggcg gtgcggcggg cgttccccac actgcggcgc gatccgccgc acctccggtc
     1141 cgggtggcag gcggttcggt acgtcgccga gacgctgacc ggcgacgacc ggctcacccg
     1201 gctgctgcgg gagctcgggc agtggtcgcc gggcggcatc gggccgggta tcgcggcctg
     1261 gatgcggcgc tggatgccgg gggagggcga gtacgcgggt gcgggggtgc tcggcgggga
     1321 gctgtacggc ggtctccagg ggggatgggg cgggggcggg cgggctgagg cttgcgctcc
     1381 caccggctcc gtcatgttcc gcgcggagcc catgacccgc ggcggcagcc tggagctgtc
     1441 cgtgtgcacc gtcgtcgacg gcgtgccggt cgggcgggcc gggcccgtgc ggatccgccg
     1501 ccagcagctg cgggcgcgcg tcgaggcgct gctcgccgaa caggtcggca ggatccacga
     1561 gttcgactgg atgctggagt tcgtggtgcc gcccgggctg atgagcgagc cgtacgagga
     1621 gtggcacatc cgcgagccgg gcgccgcgcg gccccgcccc atgcgcaccg tccccgtcgt
     1681 cgtccggcac gtggaacgcc tgaagccgct caccgtctcc cggctcaccc gcaaacgctg
     1741 gcagaccgtc cgggcccgcg gcgagacccg gcccgtgccc gtcgagtgcg gactgccgta
     1801 cggctacgag cagttctacg gctggctcga cgccgacgac gacctgtgcg ccctcgcgta
     1861 cgccgcccgg cccgtcgacg actggctgtc ggccgccctc gacaccggtg tacccatcat
     1921 gctgtggcgg cggcacgact gcggcggcga cgggcacgcg cactgcgcgc cgaaggcgtt
     1981 cctggaccgg ctcgccgatg ccgtggccac ccttgagccc gatcgactcc ccttggaagt
     2041 aatgaagttg cgcaaggcgg cgcactcccc gcacaagggg gacgccgacc actgcgggca
     2101 ccgcctgacg ctgttctggg acgacccgga acgcatgccg gatccaccgc tggccatggg
     2161 gaaccccatg gggagcagag ggagcgcctg agatgccgcc gtcggagaac gcgccaccgc
     2221 ccgaggtccc accgccgggg cgccggtcgt ccgaggtccc acggcccgag accccgtcgt
     2281 ccgcgtcgtc gggggcctgg tcgtccgatg ccccgccgtc caagtccccg tcgcccaccg
     2341 gccccgcccc ggccccaccc cccgcctcct ggcagatcta ctccggctcc cgcaccccgc
     2401 acgacggcat cacccgcctc ccggccccgc ccccctggcg gaccttcaag ggcggcccgc
     2461 ccctgcccac cccgcccggc gactccggca accagcacgc ggccgtcagc taccgcccga
     2521 gcgcggacgc cgtccggcag gtcaacgccg ccctctatct gcgcaggccg ctcctggtca
     2581 ccggcgctcc cggcaccggc aagtcctccc tcgcctacgc cgtcgcgcac gaactgggcc
     2641 tcggcaaggt cctgcactgg ccgatcacca gccgcgtcac actccgcgac ggcctctacg
     2701 cctacgaccc cctgacccgt ctctacgccg ccgaacgcgc ccgccacgac ggcacgcgcg
     2761 gcgacgccag ccaaggatgc gcaggccagg gccccgcagg cgacggaccc gtcggcgacg
     2821 acatcggcga ctacctccgc ctgggccccc tcggcaccgc cctgctgccc ttcgcgcgcc
     2881 cccgcgtcct gctcgtcgac gagatcgaca agagcgacat cgacctgccc aacgacctgc
     2941 tcaccatctt cgagaagggc tcgtacgaac tcgtggagct ggcccgccgc gcggcaccca
     3001 ccgcccgggt gatgacggcc gacagcacca aggaccgggt ggagatccgc gacggcaccg
     3061 tcacctgccg tgccttcccc ctcgtggtga tgacgagcaa cggcgaacgg gagttcccgc
     3121 ccgcgttcct gcgccgctgc gtcaccgtgg acctgaagca gcccgccacc ctcgacgagc
     3181 tgaccgccat cgtccgcgag cacctgggcc ccgtcgtcgg ggacggcacc ggcgtgctcc
     3241 cggtcggtgt gcaggacgtc atccagcggt tcttcgaccg gcgcagcggc ggtctgctcg
     3301 ccaacgacca gcttctcaac gccatctaca tgtgccacca cgcggccttc acggaaccgc
     3361 ccgagagcgt cgcgaggctg gcggaccagg tgatgccgtt cctgaccgcc gaagcggcgc
     3421 ggtccgatga cgcttgaccg gttgcgggac ctccttgccg ccctcggccc gccggtcacc
     3481 ccgctggacc tggccgagat ggtgtggctg gcggagcggc tgccgccggg cgaggccgag
     3541 ggtgagggca cggccggggg tgggccgccc gctccgctcg gcgaggggag cgggcccgga
     3601 ggcgcccgta caccggggct ttccggcggc cacgccccgg cggccggggg cgtggagggg
     3661 gccggggaat ccggcggatc cggggacgcg acgggcggca gccccggcca cgacgggcac
     3721 gacgggcatg acgcccccgg cccggcccgc gcgggcgccg acgcccccgc cgacggcgcg
     3781 cccggacccg ccagaaccgc cctgcacctc ccgcgcggcc ccgcccgccc cggcactgac
     3841 gccgacgacg tcctcgtacc cgccccacag gccctgcgcc acgagctggc catccagcgc
     3901 gccctgcgcc ccctgaagca gcgcgtcccc gaccggcgcc gccgcgtcct cgacgaggcg
     3961 gcgacggccg cgcgcgccgc ggaacacccc ggatcgctcc cctgggcccc ggtcctggtg
     4021 cccgccaccg accggctctt cagcctggcc ctcgtcgtcg acaccggtcc ggcgatgagc
     4081 gtatggcggc ctctggtccg ggagttgagg gaggcggtgc agcgtacggg cgcgttccgg
     4141 gacgtacgcg tatggcgcct cgccgacctc gggaagcgcg tcggcgtccg ctcctcgtcg
     4201 cggggccccg ccctcacgcc cgcggccgtg gtcgacccga cggggcgtca gatcgtgctc
     4261 gtcctcagcg actgctcggg cccgcactgg tggggcggcc gggcgggccc cgccctgcac
     4321 ctgtgggccg gacgcggtcc caccgccctc ctccagccgc tccccgaacg cctctggcgc
     4381 cgcaccgccg cccccgccgt ccccggccgc gccatcgcgc cgcgcgcggg cgcccccaac
     4441 acggccctgc ggttcacccc gcacgacggc cacgcccgcc gccccgccgg gacggtcccc
     4501 gtccccgtcc tggaactggc ccccgagtgg ctggccgact gggccgggct cctcatggcc
     4561 gccggcgacc accaccgcga caccgccgtc acctacgtcg gccccgacgc ccgtccacag
     4621 gaccaaccgc tggccgacga gggcgatttg cccatcaccg aacgcatcct ccgcttccat
     4681 tcggccgcct cgcccacggc cgccgacctc gcggcgcacg tcgccctgtc ggtgcccgcg
     4741 ctgccggtga tgcgcctcat ccagcagcgc gtcacgcccg gctcacggcc cagcgacctg
     4801 gccgaggtcc tgctgagcgg cctcctggag ccggtcgacc cggcccgcgg cctctacgac
     4861 ttcgtaccgg gagcgcgaag cgccctcctg cagaccctgc cgcgtcccga gtccctcgcc
     4921 gtcgccgagc tcctcggccg catcggcgcg gagatcgagg cccgggcggg ctcggcgacc
     4981 agcgcgttcc gggcggtggt ggcggtggcc cagggggcgg ggagccgggg gctcggggtg
     5041 gccggggagc cgttcgcgtt ggtgagcgag gaggcgttgg gggtgttgcg ggggcgggcc
     5101 attccggtgg tggagcggcc ggtggaggtg gcgggggagt cggccgtcgt gccgcccgcg
     5161 cccgctgtgc cggcggtggc gaacgtcccg acgcgcggca ggtcgttcgt cggccgcacc
     5221 agcgaactcc agcgcctgga agcggacttc tccggtaccg gcgactcagc cgacaggctg
     5281 cgcgtggtcg tcgtccacgg catggcgggc gtgggcaaga cggagctcgc ggcggagtgg
     5341 gtgcggagcc gtccgggggg ctcccggtgg tgggtgcggg cggactcgcg ggaggagatc
     5401 gacgagggcc tgcacgtgat gggtcgcgcg ctgaacccgg ctgtcgtgcc cgcgctgccc
     5461 cggagcgcgg gcatcgaatg gactgtgcgg tggctggcct cgcacgcgga ctgggtactc
     5521 gttctcgacg acgtgcgcga ctcctccgag gtgcgcgagc tgctggcccg actcgactcc
     5581 ggcggccggg tcctggtgac cactcggaac acggccggat ggggctcgat gctccatgag
     5641 ggcctggacg tcgccctgaa gtcgttgccg ctcagtgcgc tgcaactccc ggaggccgtc
     5701 gagttgttga ggactcgggc gggcgctggg gcggtgttgg acggcgcggc ggcgctctgt
     5761 gaggagctcg actgtcatcc ggccgcagtg gtgcgggccg cggcggacat cgcccgtacg
     5821 ggaatgtccg tcgcggagta ccggacgctg atcggccgcc gtccgggcca cgaagagacc
     5881 tccctgctgc cgcgggtggt gcgcgcgtcc aaggacccct tggcggcgcg actcctgaac
     5941 atgctcgcgt ggctggcacc cgatcccgta ccgcgctcgg tggtgtcccg catggcgggc
     6001 gtccgggagc tgggcagcgc cctgcggctc ctggaaggcc tcgacctcgt cagtgtcgac
     6061 gacgaggtga tccgggtgcg ccccggggtc cagtccgcgg tccgcacggc ggacgactcc
     6121 accccgttgc ggagccgcga ggccgtcgcc tgggcccgcg ccgaggccgc cgtctgcctc
     6181 gccaataccc tgccgcggga cccgaacgcc gtctatgcct ggccccgctg gcgcgaagtg
     6241 ctgccgcacg tcctcgcgtt ggcggagcac gtccgacccg aggacgactc cgcgccgctc
     6301 gcctcctcgc tctcgctggc ggcgggatac gtcctcgccc aagggcagcc ggaccgggcc
     6361 gtcgggatgc tggagcgtgc cgtcgagagc ctgcgcagga tctccggggc ggatgcgccc
     6421 gagaccctgg cggcggccgg gcagctcgcg ggggcgtacc gggcggcagg ggacgtgcgg
     6481 cgggccatcg cgctgtatga gagcacggtg ctgaccctgg gcagggcgct cggtgcggga
     6541 cggagcgaga ccctggagct ccggctcgaa ctcgcggcga cgtacctgga actggggtcc
     6601 gtgccggagg cccggcagca gttcgacgcg gtgctacagc tgagcagggg gtggcacccg
     6661 cagttcgttc ggcacgcgct gaccgcacgc gcgggcctcg cggacaccct gctggaggac
     6721 gacgcgcagg acgcgctgtc cgtgtacgag gacatcctgg ccgagtgccg caggatgctc
     6781 ggcgacgagc acccccacac gatctacgta cgcggcaagc tgtccgctgc cgcccacagg
     6841 gcgggcgatg acgcgcgggc gcggagcgcg gcggagtcga cgctggccgc ctgccgtcac
     6901 gtcttcgggc acgaccacct gcggaccatc agggccatgg gcgatctggc gtatgtgtac
     6961 gaaggctccg agcgccttcg gccccgggcg atcgaggcgt atgaggaggc ggtggggcac
     7021 agcacggtgg tacgcggcgc gagccacccg gggaccctgg ccttgcggga ccggctcgcg
     7081 gcgttgtacg cgcgggacga gaactggcag cgcgcgatcg cgcagtacgc gaagttgctc
     7141 gcggtccgcg ccgccgagct gggcgaagac catcctggga ccctgcgtac ggtggcacac
     7201 ctcgccgagg cgcacagctg cgccgggtcc tggcgcaggg ccatcgcgct gcacgaacgc
     7261 gtcctcgacg ctcagatcag atcactgggg gacgggcacg ccgacacctg gccgtcctac
     7321 gaccggctcg cggaggccca gcgaggggtc ggcaatgtgc cggaagccct caggctgtac
     7381 aagagggttc tggacttcag gacggcggcg ctgggcaggc agcaccccga caccgtgacg
     7441 acgctcgaag ccatggcccg cgtccacttg gacgccgacc acttggacct ggccctcgac
     7501 gcgtacgcgc aggccctgga gctgcggcgc ggcgcacagg gggagttgca ccccgacacg
     7561 ctcgccgctg tccgtcgcgt cgcctggctg tacgcggagg cgggtgacac cgagagtgcc
     7621 gtcgtgacgt accgcacgac cgtgaaccac tgtgccgccg tgggcgatgt ctggcaggcg
     7681 gtcgctcttc ttgagtgggc cgggcagcat gtggcccccg cactcggcgc cgaccatccc
     7741 gagtccctca ggatccggga agagctggac cacctgcgcc gccgctgaac ggccgacgcg
     7801 ggtggtccgg aggagttacc cgtccggcag gacctacatc tccgccgggt cgggcccgag
     7861 gcgccggtcc tcgttgagcg cgctgattgc cgccatgtcc tccgggtcca gctcgaagtc
     7921 gaacacgttg atgttctcct tgatgcgggc gggggtcacc gacttgggga tggccacgtt
     7981 cccgagctgg atgtgccagc ggagcacgat ctgggcgggc gagcggccgt gcttctgggc
     8041 gatggcgacg atcgccggga cctccaggag gcccttgccc tggccgagcg gcgaccagcc
     8101 ctccgtggcg atgccctgct cggcgtggta cgcgcgggag gcgcgctgct ggaggtgcgg
     8161 gtgcagctcg atctggttca ccgcggggat caccgacgtg gcgtcgatga ggcgctccag
     8221 gtgctccgga aggaagttgg agacaccgat ggacttggcg cggccatcgg cgtggatctt
     8281 ctcgaaggcc ttgtacgtgt cgatgtacct gtcctccgac gggaccggcc agtggatcag
     8341 gtacagatcg acgtagtcca ggcccagccg ctccagggag gcgtcgaacg cgcgcagcgc
     8401 gcggtcgtac ccctggtcgg tgctcatgag cttcgtcgtg acgaagagct ggtcgcggtc
     8461 gataccggag gcggcgatgc ccttgccggt gcccacttcg ttctcgtaga gggccgccgt
     8521 gtcgatactg cggtacccgg actccagggc cgtcgccacg gcccgctccg cctcgtcgtc
     8581 cggcacttgc cagacaccga agcccagctg cggcatctcg atgccgttgt tcaggatgat
     8641 cggggggacc ttgctcacga gctctcgatc cttatgacgt cgtcgggtgg tacgtccatg
     8701 gtcaacgatc aggggccgtg gcgcattcct ggcgtggcgt tcccgctgta cggcgccctg
     8761 agaatggcta gatatagctc cgaccttatc ggtccgaacc attgaccgcg tcccgtcatg
     8821 acgcaactct gttgcacgtc actgaacgca ggccatccat gtgaactccc tggacgcatg
     8881 cgtggcattt cgtcccagtg actcctgaac ccccactttt caggaagggt aggaacacgc
     8941 gcatgaacac tcacgagatg gagacgtcgg aggtcacctc ggtctctccc gagaccgggc
     9001 ccgccaccgg ctggcagacc ccggagtaca cgatcgtgga gacctcgctc gaggtcaccg
     9061 cgtaccgcct cgccgaccgg tagacccgcc cgatgctgct ccaggtgctc ggcaccgcgg
     9121 cgggcggcgg actcccccag tggaactgcg cgtgtcccgg ctgtgccggg gcgcgcgccc
     9181 acccggaacg ccgccggctg cacgcctcgc tcgccctgcg cgcgagcccc ggccgctggt
     9241 acctcatcaa cgccaccccc gacatcggcg agcagatcga ggcctgcccc gagctgctgc
     9301 ccgcaccggg gccggccgcc gacacccggc tctccccgct cgccggggtc gtcctcaccg
     9361 acgctgaact cgaccacacc ctcggcatcg cccggctgcg cgaggcccgc gacggcgtcg
     9421 acgtgctcgc caccgcgccg gtgctcgacg ccgtccggga ccgcctcggg ctcggtgccg
     9481 tgctcgaccc gtacacgcgg acgcgctggc gcgagctcac gggcgcgcgg cagcaactga
     9541 acgaccattc agcagtgcgg gtcgatgcgg tgcgcgtttc ggccaagcgg ccgcgctacg
     9601 cggccggcct cggcccggac gacgccgcct ggtccgtcgc cctgcgcctg cacgacaccg
     9661 ggacgggccg caccgtcctg tacgccccgg cgctcgccgc ctggaccgac gccttcgagg
     9721 aggccgcccg cgaggcggac gtcgtcctcg tcgacggcac cttctggggc gaggaggaac
     9781 cccgacgagc cggattcagc gaccgcacgg ccaccggcat gggccatctg cccatcgccg
     9841 ggcccggcgg caccgcccac cggctcgccg ggctgcccgg acggtgcctg tacacgcacc
     9901 tgaacaacac caacccgctc ggcgaccccg acgccgagca gcacaagcaa ctcgccgact
     9961 ggggactcga agtcgcgcgg gaccggatgg tgatcgagct gtgaccgcaa ccgtcaagac
    10021 cgccgcggac tccgcggccg gggccgacga cgcgccctgg acccccgacg aactcaccga
    10081 gcggctgcgc gccgtctccg ccgcgcgcta ccacgaccgc caccccttca acgtacgcat
    10141 gcacgaaggc accctgaccc gggccgagtt gcgccgctgg atcgccaacc gcttccacta
    10201 ccagcggcac atccccatca aggacgccct gatcctcgcc aagttcgacg accccgcgct
    10261 acgccggggc tggtcgcggc ggatcaggga ccacgacggg gaccgccccg gcgagggcgg
    10321 catcgagcgg tggctgcggc tcggcgaggc cgcggggctc gctcgcgcgg agctgctgga
    10381 cacctcccgg gtgctgcccg gggtgcggct cgccgtcgac gggtacgtca acttctgccg
    10441 tctgcggccc gccctcgacg ccgtcgccgc ctccctcacc gagctgtccg cgcccgatct
    10501 gatgcgcacc cgcatcgccg cgttcgagca gcactacccg tggatcgaca ccgaagggct
    10561 cagctacttc cggggccgcg tcggccaggg cggccgggac gggcaggagg cccttggcct
    10621 ggtgcgtgcc tgggcccgca cccgggcgga gcaggagcgg gcggtggcgg cgctcggctt
    10681 caagtgcgac gtgctgtggg cgctgctcga tgccgtcgac ggggcgtccg gccgggacgg
    10741 ccagggcgcg ggggacgggg gcggtcatgc gtgaggccgt cgcgggcgag cgcccgtccg
    10801 gcgcggccgg cccgaacgcc gccgaggacg agctcgtacg tcccgactgg cggcccgtcc
    10861 tcgcccgctc cgtcgtcctg cgccgcgacc gggtccgcgg cgccgacctg ctcctactgc
    10921 ccgagcgcgt cgtggtgctg cgcggtgccg ccgccgccat cgtggcgctg tgcgacgggg
    10981 agcgggacgt ggccgggatc gtcgcggagc tgcggcggcg ccacccgggc gcgccggtgg
    11041 gcgacgaagt gccggtgttc ctggggcggt tgcgggcgga gaggtggctg cgatgagcgt
    11101 tgcccccgaa ccgccctggg ccctcctcgc cgagctcacc cacggctgcc cactgcgctg
    11161 cgcgtactgc tccaacccgg tcaaactgaa cagtcggtca gaagaactga ccggcgacga
    11221 gtggggcgac gtgctgcggc aggccgctga cctgggcgtc gtccagacgc atctgtcggg
    11281 cggtgagccg ctgctgcgcc gcgatctgcg cgacatcgtc gcggcggcgg acgcggccgg
    11341 catccacacc cagctcgtca ccagcggcgt cggcctgcac gaggcccgcc tcgccgggct
    11401 cgtcgacgcg ggcctgcgca gcgtccagct gtccgtgcag cacgccgacc ccgcccgcgc
    11461 cgacctcatc gccggggccc gggccaccgg cgccaaggag cgcgcggccc gcctcgtccg
    11521 cgaggccggt ctgccgctcg gcctgaacgc cgtcctgcac cgcgccaacc tcgacgccct
    11581 cgacgcgctc gtggagctgg gcctcgactg gggcgccgac cggatcgagc tggccaacac
    11641 ccagttctac ggctgggcgc tgcgcaaccg cgacgcgctg cttcccgacc cggaccaggt
    11701 ggaccgcgcc cgggggaccc tggagcgctg gcgggcccgg ctcggcggcc ggatggagct
    11761 ggtgtgggtc gcgcccgact acgtcgacgc caccgccaag ccgtgcatgg gcggctgggg
    11821 cgcggtgtcc ctgaccgtcg cgcccgacgg cacggtgctg ccctgcccgg ccgccgcgga
    11881 actgctcggc gcggacgccc cgaacgtacg ggaccggccg ctggactgga tctggcggga
    11941 gtcgcccgcc ttcacccgct accgcggcga gggctggatg cgggagccct gccgctcctg
    12001 cgagctgcgc accgtcgact tcggcggctg ccgctgccag gcccacgccc tcaccggcga
    12061 cgccgcccgc accgaccccg cctgtcaccg ctcacccgac cacggcgtgg tgcgcgccct
    12121 ggtcgaggcg gcgcgcgggc ccgcaccgga ccaccccggt tacgcctacc gcgagggagg
    12181 aacctgatgc gccgccatcg ctcacccacc tcaccgatat cgaccccgct gcagtccgcc
    12241 ccgcccaagc cccccgcccc gcccacggga ccgcgcggca aggcggcccg cgccgtcctg
    12301 gccgcgctcc tcgcgggctg cgccgccctc accgcgcaga cggcccccgc cgcggccgag
    12361 ggcccgcctg ccgccgaccg gacgcccgcc cccgaccgga cgcacgccgc gcagcctcgg
    12421 ggcaccgact ggtcccgcgc cctggtcgac tcgaccacga cccggttcac gcccacctcc
    12481 atcggcggct ggtcctaccc cgtcggcctc tacctcttcg gccagtacgg cacgtaccaa
    12541 cgcacccacg acgcccgcta cttgacgtac atcaagagct acgtcgaccg gttcgtcgac
    12601 ggcgacggga acatcgggca gaagttcaac agcctcgaca gcatgcaggc cggacggctc
    12661 ctggtgatcc tgcaccacga gaccggcgag gaccgctacc gcgtcgccgc ccggaagatc
    12721 cgtgaccgtc tgaagagcta cccgcgcacc ggcgacggcg gcttctggca cgccgacacc
    12781 gacagccgcg cgcaccaact ctggtcggac ggcgtctaca tggtcacgcc gttcctcgtg
    12841 gagtacggca aggagttcgg cgacgaggcg tacaccgacc gcgaggccgt cgagcagctc
    12901 aacgtgtacg cgcgccacct ccaggcggac aacggcctgt tccagcacgc gtacgacgag
    12961 tcgcgcaccg cgagctgggc cgacaaggac accgggcgtg ccccggagca gtggtgccgg
    13021 gccatcggct ggtactccat ggccgccgtc gacgtcctgg acgccacccc acgcagcgac
    13081 cccgggcgtg gcgagctgct cggccacgtg cggaagctgg ccgggggcat cgcgaaagcc
    13141 caggacccgg cgaccggtcg ctggttccag gtcgtcaaca aggggacgca ggaaggcaat
    13201 tggacggaga cgtcctgctc cagcatgttc accttcgccc tgtcccgcgc cgccgagaag
    13261 ggctatgtcg cgccgtcgta ccagggcgtc gcgcgccgcg gctacgaagg cgtcctgaag
    13321 aagatctcgc tcggcgccga cggtctgacc aacctcacgg acatctccat cggcaccaac
    13381 gtcggcgact acgccttcta catcgcccgc ccccggcaga ccaacgactt ccacgggctc
    13441 ggggcatttc tgatcatgaa cgagcaactc aggaagcaga ggtgaccccc tcatgacccc
    13501 ctcccgcaga gccctcttcg ccgcggcgct cggcaccggc gcgggtgtgg ccgccaccgc
    13561 ggtgggcctc tcgccggccg ccgcggcccc caccgcggac tggcagctgc gctggtcccc
    13621 gtccgcccgc gacgtcggcc tgcgcgcctt cgagacgctg gaggacgacc gcgccaactc
    13681 ccacccggcg gcgaagccgc acatcttcgc cgagggcgac aacttccgct tcaccatgca
    13741 caccgtcgac cgcgacacca gcgacgaccg ccagcgccac gaggtcaccg ggctgcgcac
    13801 cggcaactcg ttcctcacct ggcagcgggg gcagacctgg cgggtcacgt accgcatgtt
    13861 cctgcccagc acgctgaagg cgacgacgag cttcacgcac atcatgcaga tgaagcagcc
    13921 cggcgcgggc agcgcgccga tcgtcgtgca gtcgctgcgc cgcgtcgacg gcaagcagac
    13981 catcgagctg aagatcttcg acgacgacat cctgatcggc cgcaccgacc tggcgccgct
    14041 gcacgacaag tggaccgacg tcgacttcca gatcaagatc ggcgacggct cgtcggggtc
    14101 cgtgcgctgg atcctcaaga gcggcggcac gaccgtcatc gacaagtcga agaccggcat
    14161 cgacaccttc ctcgccgacc gggtgcggcc caagtggggc atctaccgct ccctcggaga
    14221 cacctcgggc tccctccaga acacgtacat gctcctcacc ggcatgcgcg gctaccagct
    14281 cgtctgaacc cacctgctga cgctcgtacg aaaggcaatc gacggtgcga cgactcacct
    14341 ccctgagcgg cctggccctg gccgccgccg ccctcctcgg actgtcccaa ctgcccgcgg
    14401 ccgccgacag cgcgggcacc ggggccgccg acgcgggcgc cgccaagacc gccgccccca
    14461 aggccgcggg caccatccac gccgccccct acgagtacct gggctggggc agcccgcaga
    14521 agcccaccga cgtgatggcc gcgaccggcg tcaagtggtt cacgctggcg ttcatcctgt
    14581 ccgacggcgg ctgcaacccc gcctgggacg gcagccgtcc gctgaagggc ggctccgacg
    14641 agtccgccat caagtccatc cgggcggcgg gcggcgacat cgtcgtgtcc gtcggcggct
    14701 ggagcggcgc caagctcggc gagaagtgct ccagcgccac cgccctcgcg gccgcttacc
    14761 agaaggtcat cgacgcgtac aagctgaagg ccttcgacgt cgacatcgag aacaccgagt
    14821 tcaacaaccc gaccgtgcgt cagcgcgtcg tcgacgcgct gaagatcgtg gagcagaaga
    14881 acccgggcat cgtcacctac gtcaccctcg gcaccacccc gaacggcccc gacgccaccg
    14941 gcaaggacct catccagcgc ggcgcccggg ccgggctcgc cgccgacgcc tgggtcatca
    15001 tgccgttcga cttcgacggc cacagcggca ccatgggcga ggcctccgtc agcgccctcg
    15061 aaggcctgaa gaacaccgtg cggagcgcct acggctacag cgacaccgac gcctaccggc
    15121 acatcggcgt ctcgtccatg aacggcagga cggacgtggc gggggagacc gtcaccaccg
    15181 ccgacttcaa gaagatcctc ggctacgcgc aacagcacca catcgcccgc ttcgccttct
    15241 ggtccgtcaa ccgcgaccgc tcctgcgcgg gcggcggatc ggcgggcgac tcgtgcagcg
    15301 gcatcggcca gcagccttat gagttcacca agatcgtggc ccagtacgga ggctgacggc
    15361 gcgtcagcac ctcgtacgac acccccatct gaccccccac atggaggttc gcatgcacgg
    15421 caacacgagg aacaccggcc tggcgcggaa ggtggcgctg gcggcggcca ccgcgctggc
    15481 ggcgggagtg gtggcgtacg tcccgtcggt gtcggccgct ccggccgcgc ccgccggtga
    15541 gcccaccgac atcaagaccg tctcgaccgg ctggaccata ccctggggca cctcctggct
    15601 gcccgacggc aagtccgcgc tggtcaccga gcgcgacgac ttccgggtct ggtcgatctc
    15661 ggccgacggc gcgacgaaga agcaggtcgg cacggtgccc gagtcccaga cgacgggcgg
    15721 cgagggcggc ctcatgggcg tcgccgtgga cccgcagtgg gcgacgaacc actacgtgta
    15781 cgtcatgcac acctcgtccg agggcaaccg cgtcgcgcgc atgacgtacg acggctcctc
    15841 cctcagcggc tacaccgtgc tgctcaaggg catcaagaag gccaggtacc acaacggcgg
    15901 gcgcctcgcc ttcggccccg acggctatct gtacgccacc acgggcgacg cccaggaccg
    15961 gccgctcgcg caggacaaga actccctcaa cggcaagatc ctgcgcatga cccgggacgg
    16021 caagcccgcc cccggcaacc ccttcggcaa ctacgtctac agcctcggcc accgcaaccc
    16081 gcagggcatc gccttcgacc cgcagggccg cctgtgggag gccgagctgg gcgacgccac
    16141 caaggacgag ctgaacctca tcaagcccgg caagaactac ggctggccga cctgcgaagg
    16201 caactgcaac gtcgccggga tgaccaaccc gaagaagacg tggggcgtcg ccgaggcctc
    16261 cccgagcggg gtggcgatcg tcgacggcgc ggtctacatg gcggccctca agggccagcg
    16321 catgtggcgc atcccgatca acgccgacaa cgagaacgtc ggcacggcca aggcgttcta
    16381 cgtcggccag tacggccgcc tgcgcgcggt gaccaccgtg ccgggcgcga aggcgctgtg
    16441 gctgtccacg accaacgcgg acggcaacgg cgggcagccg gacggcgcgg acaagatcct
    16501 ccgcgtgacc atcggctagt cacggccacc gaccggtcgg gcggcggccg cgcgctgtgg
    16561 gggcgggcgg ccgctgtccg gccaggccgg ggtgagaacg gcccggccgg gagcgagaac
    16621 ggtccgcggg cgtacgggcc ccgggccgcc gacgcacagc gaggggacgg gacatgagca
    16681 gatcacgcac acgcaccgga gccctggccg cgggcctcgc cgcgctcgcg gtgctcgcgg
    16741 tcttcgacgg gccgtccgcc ggagccgtcc gggtccgcgc ggaggcggcc accgcggcgc
    16801 gcgcaccggc acctcaacgg ccgctccccg cagccgagtt caacgtccgc gactacggcg
    16861 cgaagggcga cggatcgacc aacgacacgc ccgcgatcca gcgggccgtc aacgcggcca
    16921 acagcgcggg tggcggcacc gtgcgcctgc ccggcggtgg ctcgacgtac gaatccaaga
    16981 acaccctcca catgaagagc gatgtgacgc tccaggtgga caagggcgcc accctctccg
    17041 gcaacggcgc ggacgactac gacccgcccg agcccaacga gtgggacgac taccaggact
    17101 acggccacag ccacttccac aacgcgatga tccacggcga ccggctgagc aacatcgcgt
    17161 tcgtcggcga gggcgtcatc gacggcgacg gcgccctgat caccggcaac ccggaatccg
    17221 gcgaggccga caagatcatc tcgctgacgc gctgcaaggg cctgcgcctg ggcgacgggc
    17281 tcaccctgcg cgagggtggc cacttcgcgg cgctcgtcaa cggctgcgac gacgtcgtct
    17341 ccgaccggct caccatcgac accgcgatgg accgcgacgg ctggaacgtc atcaacacca
    17401 ccgacgtgac cgtcacaggc gcccacctgg acgccaacga cgacgcgctc gcgttcaaga
    17461 gcgactacgc gctgggcgcg aaactcccca acggccgtgt gcgcgtgagc gattcgtatc
    17521 tgtcggccgg atgctgcaac gccctgatgt tcggctcgga gacctgcggc gacttcacgg
    17581 actaccgctt cgagcggatc cgcatcgagg gctcggacaa gtcgggcctc ggcatggtgt
    17641 cgatggacgg ctcgaggatc tccgacgtgc actacaagga catcaccatg accggcgtgc
    17701 gctccccgat catgcagaag atcggcaacc gcaaacgctg cggcaacaac ccgggcgtcg
    17761 gctcgatcag cgacatcacc tacacgaacg tcaaggcgac cggctcgacc ccgtccttct
    17821 cgccgaccct gtggggcgag tccgggcaga gccgcatcaa ggacgtcacc ttcaccaacg
    17881 tcgacctgac ggtccccggc ggcaacggca ccatgtccac cgacgtcccc agcaacaagt
    17941 ccaccgacta caacccgaag agcatcggca cccggcctgg ctacggctgg tacatccgcc
    18001 gagccgacga cgtcacgttc atcgacagcg aggtccgctt cgcgtccgac gacggccgcc
    18061 ccgcggtcgt cgccaacgac agcacgggca tccgcttcag caccttcacc gcccaacgcg
    18121 gctccgcaag ccccgccgac ctcgtcttcc agcagacccg tggctactgc gtccgcgaca
    18181 gcgcgaacac ggggggcggg gtgttgcggg tcggccagag cgggtccagc gaggactgcg
    18241 gctgacctgc cgatggccgc gcgcgtcccg cgtccggcgc gggtcagctg tggtacagcg
    18301 cctcgacctc gtccgcgtac gcctgctcga tggccttgcg cttgagcttc agggacggag
    18361 tgaggaggcc gtgctcctcg ctgaactggt gggccaggat gcggaaggtg cggatggact
    18421 cggcctggga gacgagggtg ttggcggcca cgacggcgcg gcgcacctcg gtctccaggt
    18481 cggggtcgcg gaccaggtcg ccggggggca gcgggggttt gttgcgcatg gagagccagt
    18541 gctcgacggc ttccgcgtcg agggtgacga gggcggcgat gtaggggcgg tcgttgccga
    18601 cgacgatgca ctgggcgacc agggggtggt cgcggacgcg ctcctccagt tgcgccggtg
    18661 agacgctctt gccgccggag gtcaccagga tctccttctt gcggccggtg atggtgaggt
    18721 agccgtcgtc gtcgagggcg cccaggtcgc cggtggcgag ccagccgtcg tgcagggtcg
    18781 cgtcggtggc cttggggtcg ttgaggtagc cctggaaaac atggccgccg cgcagccaca
    18841 cctcgccgtc ctcggcgatg tgcacggtgg tgccggggat ggcctggccg accgtgccgt
    18901 agcgggtgcg ctcgggcggg ttggcggtcg cggcggccgt ggactcggtc aggccgtagc
    18961 cctcgaagac ctgcacgccc gcgcccgcga agaacaggcc gaggcgccgg tccatggcgg
    19021 agccgccgga catcgcgtgc cgcaccctgc cgcccatggc gtcgcggacc ttggcgtaga
    19081 cgagcttgtc gaagacctgg tgctgcatgc gcagggccgt cgaaggaccg gggccggtgc
    19141 cgaaggcctt ggcctccatc gcgtcggcgt accgcaccgc cgcctccacc gccttgtcga
    19201 acgggcccgc cttgccgtcc cggtcggcct tgcggcgggc cgcgttgaag accttctcga
    19261 agatgtacgg cacggccagg atgaacgtcg gccggaacgt ggcgaagtcg gggatcaggg
    19321 cggcggcgtt caggctcggc tggtggccga acttgacgcg ggcgcgcacc gccgcgatct
    19381 gcaccatgcg gccgaagacg tgcgcgagcg gcaggaagag gagcgtggac ggctcgtcgc
    19441 cgcgcttgga gcggaacacc ggctcccagc gctcgatcag cgtgtccacc tcgaacatga
    19501 agttcgcgtg ggtcaggacg cagcccttgg ggcggcccgt ggtgccggag gtgtagatga
    19561 cggtggcgac ggagtccggc gtgaccgccc ggcggtgccg gtgcaccacc tcgtcgtcca
    19621 ggtcgcgccc ggcctcggtg agttcgcgta ccgcgtcgcc gtcgagctgc cacaggcggc
    19681 gcagctgcgg cagccggtcg acgaccgagc cgatcgtcat cgcgtggtcc tcgtgctcga
    19741 ccatcgccgc cgacacctgc gcgtcgtgca gcatccagaa gacctgctcg gccgacgacg
    19801 tcggatatac ggggacgacc tgcgcgccca cggtccacag ggcgaagtcg aagagcgtcc
    19861 actcgtagcg ggtgcggcac atgatggcga cccggtcgcc gaaccgcacc ccttgcgcga
    19921 gcagcccttt ggcgagcgcc aggacctcgt cgcggaactc cgcggacgtc acgtcctgcc
    19981 agaccccgtc gtgcttgcgg ccgaggacga cgcggaccgg atcctcaagg gcatggtcga
    20041 acacggcgtc ggcaaggccg cccacccgcg gcgccgacgc catgggaggg ttcgtgaact
    20101 cgcgcaatgg tgctccttgt ggcgctccgc acagcgccgg tgacggtacc ccaccccgat
    20161 cccttccggg aggggggtgg gaagcaccca taggggcacg atcgtcacag gtcagcaggt
    20221 gaaatgcggc cacaagggta agggtcggac agattactga cggctgagta agtttcggtg
    20281 gcgtaatctc caccgaatct gtacctgccg attacccctg gagctgcttc tccggtgtcg
    20341 gctccgagac cgccgacggg gtctgacctg cgacgcgcgc gggtttggtc cggaccatca
    20401 ggagcaccgc gagacccgcc gcgaccccca ccgcaccggc cgtcagcgac gccccgttga
    20461 gcccggcggc gaacgcctcc cgcacgctgt gcgcggacac cgtgccctcc agtgcggacg
    20521 ccccgccccc ggccgccgtg tgcgccgcct cctggccgat cgagtcctgc atccgcgagg
    20581 tcaggaccgt gccgaacagc gcgacgccga gcgcgtatcc gagctgccgg aacgtgttca
    20641 ccgccccgcc cgccatgccc gcgttctccg gcggcaacgc cgccagcgcc gcccccgcga
    20701 gccccggcga gacgagcccc gtaccgatgc ccgccagcgt cagccccggc accagcgcgc
    20761 cccacgacga gtcggcgtcg agcaccgcca tcgccaggca gccagcgccg atcaggagca
    20821 ggccgacgcc gatgacgtac cgcgcgggcg cgccgtgcag cagtcggccg cccaccgccg
    20881 ccaccacgaa cgacgtcgcc gcgagcggaa ggaggaccag gctgccgcgc accgggctca
    20941 tgccgaggac cgtctgcagc cagatcgaga ggtacgggat gacgccgaac gcggccgcgt
    21001 tgtagccgat cgcgccgagc aggacgccgg tgaacgcggg cttgcgcagc agccgcaggt
    21061 cgatcagcgg gtgcgcggcg cggcgctcga cgaccacgaa cgcgaccagc gccagcatcg
    21121 ccaccaggaa ggtcgcgccg gtgcgcgccg acgtccagcc cacggtcgag gcccgcaccg
    21181 ccccgaagat cagcgccccc gcgaacagcg cgaacgtcac cgtgcccgcc cagtcgacgc
    21241 gccgcgccgc aggccccttt gactgcgctg agtgagccgt ctgtgccgac tcgggcacca
    21301 ggcgcagcgt cagccacacc gcggccacgc tcaccggcag gttcacgaag aagatccacc
    21361 gccagccggg cccctcggtg agcagcccgc cgacgatcgg cccgagcgcg gcggcaccgc
    21421 cgctgaccgc gccccacacg ccgagcgcca ccgagcgctg cttgccctgg taggccgcgc
    21481 cgagcagcgg cagcgtcgtc gcgaacatcg cggccgcgcc gagcccctgg acggcccggg
    21541 ccgccaccag cacctccgcg ttcgacgcga gcccgcagcc cagcgacgcc agcgcgaaca
    21601 cgaccgtgcc cgcgacctga atccgacgcc gcccgagcac gtcggccgcg gcgccgaccc
    21661 cgagcagcag cgcggcgagc gcgagcgcgt agccgtcgat cacccactgc agatcgctca
    21721 gcgacgcgtc cagggcccgc gccatgtcgg gcagcgccac caccacgatc gtcacgtcga
    21781 gcaacagcat gaatgtgccc aggcacaccg cggtcagcgg cccccatgtg cgcatcttcg
    21841 ttctcctagc gagattgtca ggtgtttcgt tcgacgtcgt acgatccgtc aggggtggac
    21901 gatcgcggtg gctgtcggcc gcgtaccgcc ggaatccgac atctgggagg cgtcagcgat
    21961 ggaaagccac actccgggta cggcggatga gctggacatg aagctgctgc aggccctgga
    22021 gaccgacggc cgggcgtcct tcagcaagat cgcgaaggtc ctcggcgtct ccgaccagac
    22081 catcgcccgc cgctaccgac ggctcaccgc cgagggcggc ctgcgcgtcg tcggcatgcg
    22141 caacgcggaa cgcctcggcc gcgaccactg gatgctgcgc ctgcggt
//
