LOCUS       NZ_BMVR01000004        11473 bp    DNA     linear   CON 02-SEP-2024
DEFINITION  Streptomyces flavofungini strain JCM 4753 sequence04, whole genome
            shotgun sequence.
ACCESSION   NZ_BMVR01000004
VERSION     NZ_BMVR01000004.1
KEYWORDS    WGS; RefSeq; STANDARD_DRAFT.
SOURCE      Streptomyces flavofungini
  ORGANISM  Streptomyces flavofungini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wu,L. and Ma,J.
  TITLE     The Global Catalogue of Microorganisms (GCM) 10K type strain
            sequencing project: providing services to taxonomists for standard
            genome sequencing and annotation
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 895-898 (2019)
   PUBMED   30832757
REFERENCE   2  (bases 1 to 715038)
  AUTHORS   Sun,Q. and Ohkuma,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2020) Contact:Qinglan Sun Institute of
            Microbiology, Chinese Academy of Sciences, WFCC-MIRCEN World Data
            Centre for Microorganisms (WDCM); No. 3, yard 1, Beichen W Rd, Ao
            Yun Cun, Chaoyang, Beijing, Beijing 1000101, China URL
            :http://www.wdcm.org/
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gcType assembly pipeline
            Genome Coverage                   :: 59X
            Sequencing Technology             :: Illumina HiSeq X Ten
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_014650815.1-RS_2024_09_02
            Annotation Date                   :: 09/02/2024 04:46:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,873
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,638
            CDSs (with protein)               :: 7,638
            Genes (RNA)                       :: 74
            rRNAs                             :: 1, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 1, 4 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 43 of 161
            Pseudo Genes (incomplete)         :: 137 of 161
            Pseudo Genes (internal stop)      :: 10 of 161
            Pseudo Genes (multiple problems)  :: 26 of 161
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:42:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 101160
            Orig. end                         :: 112633
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            BMVR01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11473
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11473
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11473
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6473](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6473)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            140..859
                     /gene="hemQ"
                     /locus_tag="IE274_RS10795"
                     /old_locus_tag="GCM10010349_21930"
     CDS             140..859
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643864.1"
                     /locus_tag="IE274_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21930"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_190115441.1"
                     /transl_table=11
                     /translation="MSDDAPAKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPESRLGYA
                     DEVQELFDKLGARDITVRGTYDVSGLRADADVMIWWHAETADELQEAYNLFRRTKLGRA
                     LEPVWSNMALHRPAEFNKSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRRMLKD
                     HGMMARGYPDVRANTVASFSLGDYEWLLAFEADELYRIVDLMRHLRASEARMHVREEVP
                     FYTGRRKSVADLVAGLA"
     misc_feature    complement(938..953)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.06"
                     /tool="antismash"
     gene            1219..1464
                     /locus_tag="IE274_RS40360"
                     /old_locus_tag="GCM10010349_21940"
     CDS             1219..1464
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024061.5"
                     /locus_tag="IE274_RS40360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21940"
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_372447142.1"
                     /transl_table=11
                     /translation="MWSRHLDDSPGDRAADCGARMEPLAISVRGDGEWVLVHRCIHCGV
                     LHAHRTAGDDNVLPLTRLAVRPLAQPPFPLERLGAL"
     gene            complement(1471..3111)
                     /locus_tag="IE274_RS10805"
                     /old_locus_tag="GCM10010349_21950"
     CDS             complement(1471..3111)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (119-493). E-value:
                     5.6e-22. Score: 70.5. Matches aSDomain:
                     nrpspksdomains_IE274_RS10805_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133766.1"
                     /locus_tag="IE274_RS10805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21950"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_190115442.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-27, bitscore: 91.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPATAAARYRAVRTVGTIGSLVLTALAAAPASSAATPSAATPS
                     PETLGTALAAQRAQTTGIEFGPCPKAENLPPSVECGTVAVPLDYAHPDGKQIRLTVSRV
                     EATGKSGRAVVSRQGALVFNPGGPGASGMYFPMVGPMPEWRRVAAAYDLVGYAPRGVGR
                     SAPLSCQDPKQFAKAPTHSPTHPDASYKAERIAQAKAYARGCARHAGPDLAHYTTLNNA
                     RDLEVLRAALGERKLTFMGASYGTYIGSVYATLFPGHVRRMVFDSAVNPAPDQIWYANN
                     LDQSYAFERRWADFRAWVAKHHKAYGLGTTPAEVQRSYETVRAELTHKPAGGKVGSSQL
                     RSAFLRAAYYDDYWPMRATALSQYLKGNPKPLIEQAAPHPAAAVEDENGNAVYTAVECN
                     DAAWPTDFATWDRDNSRLARLAPFETWDNAWMNLPCAYWPAPRQQALDVRTAEGALPPT
                     LILAAERDAATPYEGALELHHRLAGSTLVTEKDAGTHGIGGGTNECVNAHLDAYLLEGR
                     LPARRAACAPHREPEPRPGTRTADLRKAL"
     aSDomain        complement(1633..2754)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IE274_RS10805_Abhydrolase_1.1"
                     /evalue="5.60E-22"
                     /label="IE274_RS10805_Abhydrolase_1.1"
                     /locus_tag="IE274_RS10805"
                     /protein_end="493"
                     /protein_start="119"
                     /score="70.5"
                     /tool="antismash"
                     /translation="ALVFNPGGPGASGMYFPMVGPMPEWRRVAAAYDLVGYAPRGVGRS
                     APLSCQDPKQFAKAPTHSPTHPDASYKAERIAQAKAYARGCARHAGPDLAHYTTLNNAR
                     DLEVLRAALGERKLTFMGASYGTYIGSVYATLFPGHVRRMVFDSAVNPAPDQIWYANNL
                     DQSYAFERRWADFRAWVAKHHKAYGLGTTPAEVQRSYETVRAELTHKPAGGKVGSSQLR
                     SAFLRAAYYDDYWPMRATALSQYLKGNPKPLIEQAAPHPAAAVEDENGNAVYTAVECND
                     AAWPTDFATWDRDNSRLARLAPFETWDNAWMNLPCAYWPAPRQQALDVRTAEGALPPTL
                     ILAAERDAATPYEGALELHHRLAGSTLVTEKDAG"
     misc_feature    complement(3157..3173)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     misc_feature    complement(3159..3173)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.39"
                     /tool="antismash"
     misc_feature    3165..3178
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.42"
                     /tool="antismash"
     gene            complement(3274..4044)
                     /locus_tag="IE274_RS10810"
                     /old_locus_tag="GCM10010349_21960"
     CDS             complement(3274..4044)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972877.1"
                     /locus_tag="IE274_RS10810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21960"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_190115443.1"
                     /transl_table=11
                     /translation="MFWVPLLLLACALAALSCGRLCVAAVRAAASEARGAHEGRRLTLY
                     EAAFLSGGPGRVIDVALLSMARGRRLLLAHTGWATVVDPVAGDDLERSVLGAIGPAGQS
                     RIAPVRRAAAAGDGVRALADRLVAAGLAVPDGMWSGIAGAARQVRAAAAAVVALGVCAT
                     LLPAQGREGEMPVGVWFALPFFLTVSCLAIARFEVPTTRWASPAGRRLLGALPSRDDLT
                     SVAVRGIRALEDPALRAALSHRDPNLDGYRETRS"
     misc_feature    4056..4073
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.84"
                     /tool="antismash"
     gene            complement(4143..4898)
                     /locus_tag="IE274_RS10815"
                     /old_locus_tag="GCM10010349_21970"
     CDS             complement(4143..4898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983659.1"
                     /locus_tag="IE274_RS10815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21970"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_190115444.1"
                     /transl_table=11
                     /translation="MRSRIISGTGLVLTGLVATLAALVYPVWSYEDRSGTGLDALTSQS
                     VATEYGPLSALDRDFITKVRLAGLWELPAGQQAGERGTTRAVHTAGKHLVEGHTFLDAR
                     VREVAAALRLELPSQPSGQQRRWLAELSAVRGTAYDVKFANILRRAHGKVFALVAEVRA
                     RTRNSQVRALADDANTTVLDHIKVLEGTGLVDFDGLARDAATSTPQPPARSPAPPGPED
                     SPPPAAPVSPTPTYSLPPAVSRPAPDPRD"
     gene            complement(5001..6473)
                     /locus_tag="IE274_RS10820"
                     /old_locus_tag="GCM10010349_21980"
     CDS             complement(5001..6473)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063323.1"
                     /locus_tag="IE274_RS10820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21980"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_190115445.1"
                     /sec_met_domain="DUF692 (E-value: 5.3e-98, bitscore: 322.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLGTGIGWRPEIADAVERMPGIDWVEAVAENVCPGHLPDSLLR
                     LRERGVTVVPHGVSLGLGGAEPPDEARLRALAERAEALGSPLVTEHIAFVRAGGALTAS
                     PHLEAGHLLPVPRTRDALAVLCENVRIAQDALPVPLAVENIAALISWPGEELTEGQFLY
                     ELVERTGVRLLIDVANLHTNHVNRGEDPARALDELPVEAIAYVHVAGGFERDGVWHDSH
                     AHPVPRPVLDILADLAARTRPPGVLLERDENFPEEGELERELAAIRETVETATPMSSAA
                     APVTASAPGFSADTGDTGDTPDTADTAPALATAPAAAHPTTTPDPTGTPPTLATRQRVA
                     LAQAALLSALVAGTPAPEGFDGTRLRVQSRALGAKRADVVAKVAPELPWIVGDAYRAEF
                     LDYARTRPMTGGYRQDALDFAEHLLLAGRPEDAEGRGELTAWWLERSGPKPLDGRPLTR
                     WLRTRAARLALRRARRRTPGHEGVDAGPAPAT"
     gene            complement(6678..7445)
                     /locus_tag="IE274_RS10825"
                     /old_locus_tag="GCM10010349_21990"
     CDS             complement(6678..7445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643870.1"
                     /locus_tag="IE274_RS10825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_21990"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_190115446.1"
                     /transl_table=11
                     /translation="MGRINGTALIIAALVVTVGALAFPVWSYADRSGTGEANLNAGSVS
                     TRWGPLSATDRDFLVKVRLAGLWEIPAGQQAVERAPSKAVKEAGDHLIVGHTDLDQRVR
                     GVASQLGVELPNQPNAQQQGWLRELTDASGEDYQRKFANLLRVSHGKVFSLIAQVRDTT
                     RNSLVRQLASDANQTVLDHITMLEGTGYVDFDAIANDTAGKSTASPTGPPPPGGNAPPQ
                     PDPAGPTGDVSGTSRPSPGAPGTVNTDRPEPQM"
     misc_feature    7565..7580
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            7805..8248
                     /locus_tag="IE274_RS10830"
                     /old_locus_tag="GCM10010349_22000"
     CDS             7805..8248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643871.1"
                     /locus_tag="IE274_RS10830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_22000"
                     /product="DUF5959 family protein"
                     /protein_id="WP_190115447.1"
                     /transl_table=11
                     /translation="MASEKPIDLIRLEGEDNSVVVRITGKRPAPGRPGIDELVGEILVD
                     TAFVQGTLATSVSPEDLTQWRETLDALDGGDDSTWREGGRAPELLVELDPDGERAHVTI
                     ADHTMSLTTVTATVTLTDEWFDEAYDRLDATLRAWPVEGALRG"
     gene            8245..8832
                     /locus_tag="IE274_RS10835"
                     /old_locus_tag="GCM10010349_22010"
     CDS             8245..8832
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020904.5"
                     /locus_tag="IE274_RS10835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_22010"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_229909453.1"
                     /transl_table=11
                     /translation="MRDAAHATGADAPRWDSVEYWRAYLASYSIDVLRAYENDDWQRIS
                     DAQRAAGWLGCAGATEEQLAATEERLGTRLPPSYRAFLGASNGFSHLGPFLYEMRTTRS
                     VGWLREAEPSTWEIIRQGGPEEAAYMDRVLLISDVADAQYWLLDPGDVSPGGEWAANIW
                     ASWYPGLRERRASFAALVADERRSFEQLRDDG"
     gene            complement(8862..9740)
                     /locus_tag="IE274_RS10840"
                     /old_locus_tag="GCM10010349_22020"
     CDS             complement(8862..9740)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983656.1"
                     /locus_tag="IE274_RS10840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_22020"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_190115449.1"
                     /transl_table=11
                     /translation="MTSNAPRPGDSEPTSHTEGHPNTTTTAGTANSPGTPNPEDPGTPA
                     ALDAPASPATRYSPPASPFRVERTPRDEAPQFVLPLVARIERGAPPARTDALETAARAV
                     LTILSDERALGEGEWAQVMRDWQDARIRKVVRRARGAEWRRAEALPGITVTGKSAEVRV
                     YPPVPLDGWPKDLARLQVSGTDLDDPEPPRDPDPSTPVLWLNPDITMSAGKAMAQAGHG
                     AQLAWWDLSAPDRTAWREAGFPLSVRTAPAPRWPELTTSGLPLVRDAGFTEIAPGSCTV
                     VADHPALRRRP"
     gene            complement(10015..10200)
                     /locus_tag="IE274_RS10845"
                     /old_locus_tag="GCM10010349_22030"
     CDS             complement(10015..10200)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125244.1"
                     /locus_tag="IE274_RS10845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_22030"
                     /product="hypothetical protein"
                     /protein_id="WP_190115450.1"
                     /transl_table=11
                     /translation="MADDDEYCAPAPSTAPRPTAGPPFAECVLCRKPTEYPESYRGSTL
                     CPVCEWQEAQRTACSG"
     gene            complement(10211..11185)
                     /locus_tag="IE274_RS10850"
                     /old_locus_tag="GCM10010349_22040"
     CDS             complement(10211..11185)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645825.1"
                     /locus_tag="IE274_RS10850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GCM10010349_22040"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_190115451.1"
                     /transl_table=11
                     /translation="MITRARQRAARASLAAFAAAALTALSACASPSTPTRPHSPAPHHN
                     PQKAAPPTLAPGPQGLTPVFKNAPRTKQGAPTVALTFDADMTADQGPRAGAGERFDNPA
                     LVDTLRRLKVPATFFMTGRWAEEYPAQARAIGRSPLFEVANHSYSHYSFTPDCYGLPTV
                     APHRMRADVERAFAAFRKAGVERPVPYFRFPGGCYDQRALRALAPAGVTAVQWDVVGGD
                     AFATDPDAVARQVLDGVRPGSVVVLHCTRSAAPATERALRTIVPKLRERGFRFVRVSEQ
                     IGAARTPEGARHSGPGGPAGPAGPAGADEPARHRPERTATGPN"
ORIGIN
        1 tacgacggcg tgggcatccc ggcctgcatc gccagcgcga acgccgccgt ggaccagctg
       61 accggggacc tttccgcggt gcgggagctc accgccaacc cggtgcagag cctgcacggc
      121 ggcgcgggag aatagccgca tgagtgacga cgcccccgcc aagatcccga acgccggcaa
      181 gaaggccaag gacctcaacg aggtcatccg ctacaccctg tggtccgtct tcaagctgcg
      241 cgacgtcctg cccgagagcc gcctcggcta cgcggacgag gtccaggagc tgttcgacaa
      301 gctcggggcc cgggacatca ccgtccgcgg cacctacgac gtgtccggcc tgcgcgccga
      361 cgccgacgtc atgatctggt ggcacgcgga gaccgccgac gagctgcagg aggcgtacaa
      421 cctcttccgc cgcaccaagc tcggccgcgc cctggagccg gtctggtcga acatggcgct
      481 gcaccgcccc gccgagttca acaagtcgca catcccggcg ttcctcgccg acgagacgcc
      541 ccgtaactac gtctcggtgt accccttcgt gcgctcctac gactggtacc tgctgcccga
      601 cgaggaccgc cgccgcatgc tcaaggacca cggcatgatg gcccgcggtt accccgacgt
      661 gcgcgccaac accgtcgcct cgttctcgct cggcgactac gagtggctgc tcgccttcga
      721 ggccgacgag ttgtaccgca tcgtcgacct catgcgacac ctgcgcgcct ccgaggcccg
      781 catgcacgtc cgcgaagagg tgccgttcta caccggccgc cgcaagtccg tggccgacct
      841 cgtggcgggt ctcgcgtaag cgaccccctc cgcacgcgcc gggcgggcgc ggcaccgtta
      901 attcggttgc cgcgcccgcc cggtgcgcgt ttcatcgaga ggtcgagacc tagcaacgaa
      961 agatggtgcg tgtatgccca gggccctgcg gaacagctcg aggtcagccc cttccgcatc
     1021 gcactggagt cacttccacc atgtctcgca acatgtccat gcctcgcaac acctcccggc
     1081 gggcgcgcac tgaagcacgc gcccagtcct tccgctgcct gcagtgcggt ctcgacgtcc
     1141 cgatgaccgc gcccggcacc gatcaccgca acctccccca agctcttaaa gagcaggggg
     1201 accccctccc cgaactgcct gtggagccgt cacctcgacg actcgcccgg cgaccgggcc
     1261 gcggactgcg gcgcccgcat ggaaccactc gccatctccg tgcgcggaga cggcgagtgg
     1321 gttctcgtgc accggtgcat ccactgcggc gtgctgcacg cccatcgcac cgcgggtgac
     1381 gacaacgtcc tgccgctcac ccggctggcg gtccggccgc tggcgcagcc gccgttcccg
     1441 ctggagcgcc tcggggcgct ctgatctctc ctagagcgcc ttgcggaggt ccgccgtcct
     1501 cgtccccggc cggggctccg gctcccggtg cggtgcgcac gccgcgcgcc gtgccgggag
     1561 gcggccctcc aggaggtagg cgtccaggtg cgcgttgacg cactcgttgg tgccgcctcc
     1621 gatgccgtgg gtgcccgcgt ccttctcggt caccagggtc gagcccgcca gccggtggtg
     1681 cagttccagg gcgccctcgt acggcgtcgc ggcgtcccgc tcggcggcca ggatcagggt
     1741 cgggggcagg gcgccctcgg cggtgcggac gtcgagggcc tgctggcgcg gcgcgggcca
     1801 gtaggcgcac ggcaggttca tccaggcgtt gtcccaggtc tcgaacggcg cgaggcgcgc
     1861 gaggcgggag ttgtcgcggt cccaggtggc gaagtcggtg ggccaggcgg cgtcgttgca
     1921 ctcgacggcg gtgtagacgg cgttgccgtt ctcgtcctcg acggccgccg ccggatgcgg
     1981 cgcggcctgc tcgatcagcg gcttcgggtt gcccttcagg tactgcgaca gggccgtcgc
     2041 ccgcatcggc cagtagtcgt cgtagtacgc ggcccgcagg aatgccgacc gcagctgcga
     2101 ggagccgacc ttgccgcccg cgggcttgtg cgtcagctcg gcgcggaccg tctcgtagga
     2161 ccgctgcacc tccgcgggcg tcgtgcccag gccgtacgcc ttgtggtgct tggcgaccca
     2221 ggcgcggaag tccgcccagc gccgctcgaa cgcgtacgac tggtccaggt tgttggcgta
     2281 ccagatctgg tccggggccg ggttgaccgc ggagtcgaag accatgcggc ggacgtgccc
     2341 ggggaacagc gtcgcgtaga ccgagccgat gtaggtgccg tacgaggcgc ccatgaacgt
     2401 cagcttccgc tcgcccaggg cggcgcgcag cacctccagg tcacgggcgt tgttgagggt
     2461 ggtgtagtgg gccaggtcgg ggcccgcgtg ccgggcgcag ccgcgtgcgt acgccttcgc
     2521 ctgcgcgatg cgctccgcct tgtacgaggc gtcggggtgc gtcggcgagt gggtgggcgc
     2581 cttggcgaac tgcttcgggt cctggcagga cagcggcgcg gagcggccga caccgcgcgg
     2641 cgcgtagccg acgaggtcgt acgccgccgc gacgcgccgc cactccggca tcgggccgac
     2701 catcgggaag tacatgccgg acgcgcccgg gccgcccggg ttgaagacca gcgcgccctg
     2761 ccgcgacacc acggcccggc ccgacttccc ggtggcctcg acgcggctga cggtcagtcg
     2821 gatctgcttg ccgtcggggt gggcgtagtc gagggggacg gcgaccgtgc cgcactccac
     2881 ggacggcggc aggttctccg ccttcgggca ggggccgaac tcgatgccgg tggtctgggc
     2941 gcgctgggcg gcgagggcgg tgccgagggt ctcgggggag ggggtggcgg cggagggggt
     3001 ggcggcgctg ctcgcggggg ccgcggcgag ggcggtcagg acgagggagc cgatggttcc
     3061 gacggttctg acggctctgt accgggcggc ggcggttgct ggtgctctca tcgctgttct
     3121 gtgtcccttt cgcggcgcgg gcccaagtga ctgcgtaaat cgcaaaatca caacaaaagg
     3181 gatattcagt tcgaagagtg gcaaagtcca gcaccggaac gcgggcgtcg cgagtcgcgc
     3241 cccaatggcc cttcgtggcg gccgcgcggg acgctaggag cgggtctccc ggtatccgtc
     3301 gaggttcggg tcccggtgcg agagcgcggc ccgcagggcg gggtcctcca gggcgcggat
     3361 gccgcgcacg gccactgacg tcaggtcgtc gcgcgagggc agcgcgccga gcagccgccg
     3421 ccccgccggg gacgcccagc gcgtggtcgg cacctcgaag cgggcgatgg ccagacagct
     3481 caccgtgagg aagaacggca gcgcgaacca caccccgacc ggcatctccc cctcgcgccc
     3541 ctgcgccgga agcagcgtcg cgcacacccc gagggccacg acggccgccg cggccgcccg
     3601 cacctgccgg gccgcgcccg cgatgcccga ccacatcccg tccggcaccg cgagccccgc
     3661 cgcgaccagc cggtccgcga gcgcccgcac cccgtccccg gccgccgcgg cccggcgcac
     3721 cggcgcgatc cgcgactgcc ccgcgggacc gatcgccccg agcaccgacc gctccaggtc
     3781 gtccccggcc accggatcca ccacggtcgc ccaccccgtg tgcgcgagca gcagccgccg
     3841 cccccgtgcc atcgagagca gcgccacatc gatgacgcgc cccggcccgc ccgacaggaa
     3901 cgccgcctcg tagagcgtca gtcgccgacc ctcgtgcgcc ccgcgcgcct cactggccgc
     3961 ggcccgcacg gcggccacac agagccgacc gcaggacagc gcggcgagag cacaggcgag
     4021 gagcagcagc gggacccaga acatgccggt tttctatgtg aaggaggtgt gacgccgcta
     4081 ccggtattcc acgatgtgga caccgtcctg cccgcccgag ctgccgtttg acccgctgtg
     4141 cctcagtcgc gcgggtcggg cgcgggccgt gagacggccg gggggaggga gtacgtgggg
     4201 gtcggcgaca ccggcgccgc gggcggcggg gagtcctcgg ggcccggtgg cgcgggggag
     4261 cgggccgggg gctgcggggt ggacgtggcg gcgtcgcggg ccaggccgtc gaagtcgacc
     4321 agacccgtgc cctccaggac cttgatgtgg tcgaggacgg tggtgttggc gtcgtcggcg
     4381 agcgcgcgca cctgggagtt gcgggtcctg gcgcggacct ccgccaccag cgcgaagacc
     4441 ttgccgtgcg cgcgccgcag gatgttcgcg aacttcacgt cgtacgccgt gccgcgcacc
     4501 gcgctcagct ccgcgagcca gcgccgctgc tggccgctgg gctggctggg cagctccagg
     4561 cgcagcgccg ccgccacctc gcgcacccgc gcgtccagga acgtgtgccc ctcgaccagg
     4621 tgcttgcccg cggtgtgcac ggcccgcgtg gtgccgcgct ccccggcctg ctggcccgcg
     4681 ggcagctccc acaggcccgc gagccgcacc ttcgtgatga agtcccggtc gagcgcggac
     4741 agcggcccgt actcggtcgc cacgctctgc gaggtgagcg cgtcgaggcc ggtgcccgag
     4801 cggtcctcgt acgaccacac gggatagacc agcgcggcca gcgtggccac gagccccgtg
     4861 agcacgagcc cggtgccgct gatgattcgg gaacgcatga cgcctcctgt cgcgccaccg
     4921 cacgctagtg cgcggcgcgg gggaggcgtc ccgcatatcg ggcggagtac gccaacggct
     4981 gtacggcgcc gggggagcgg ttacgtcgcc ggggcggggc cggcgtccac gccctcgtgg
     5041 ccgggcgtcc gccgccgcgc ccggcgcagc gcgagccggg ccgcccgggt gcgcagccag
     5101 cgggtgaggg ggcgcccgtc gagcggcttc gggcccgagc gctccagcca ccaggccgtc
     5161 agctccccgc gcccctccgc gtcctcgggc cgcccggcga gcagcaggtg ctcggcgaag
     5221 tccagggcgt cctgacggta gccgcccgtc atggggcggg tgcgggcgta gtcgaggaac
     5281 tccgcgcggt acgcgtcgcc gacgatccac ggcagttccg gcgcgacctt cgccacgacg
     5341 tccgcccgct tggcgccgag cgcgcggctc tgcacccgca gccgggtccc gtcgaagccc
     5401 tccggcgcgg gcgtgcccgc gacgagggcg gagaggaggg cggcctgggc gagggcgacg
     5461 cgctggcggg tggcgagggt ggggggtgtg ccggtcgggt cgggggtggt ggtcgggtgg
     5521 gcggcggcgg gggccgtggc gagggccggt gccgtgtctg ccgtgtccgg cgtgtccccc
     5581 gtgtcccccg tgtccgccga gaagcccgga gccgaggccg tcacgggggc cgccgccgag
     5641 ctcatgggcg tcgccgtctc caccgtctcc cggatcgccg ccaactcccg ctccagctcc
     5701 ccctcctcgg ggaagttctc gtcccgctcc aggagcacgc ccggcggccg ggtgcgcgcg
     5761 gcgaggtcgg cgaggatgtc gaggacgggc cgcgggacgg ggtgggcgtg gctgtcgtgc
     5821 cagacgccgt cccgctcgaa gccgcccgcc acgtggacgt acgcgatggc ctccaccggc
     5881 agctcgtcca gggcgcgggc cgggtcctcg ccccggttga cgtgattggt gtgcaggttg
     5941 gcgacgtcga tgaggaggcg tacgccggtg cgctccacca gctcgtacag gaactgcccc
     6001 tccgtcagct cctcgccggg ccaggagatg agggcggcga tgttctcgac ggcgaggggc
     6061 acgggcaggg cgtcctgggc gatgcggacg ttctcgcaca gcacggcgag cgcgtcgcgg
     6121 gtgcgcggga cgggcagcag gtggcccgct tcgaggtgcg gggacgcggt gagggcgccc
     6181 ccggcccgta cgaacgcgat gtgctcggtg acgagcggcg agccgagtgc ctcagcgcgc
     6241 tccgcgagcg ccctgagccg ggcctcgtcc ggaggctccg cgccgccgag cccgagcgag
     6301 acgccgtgcg gcacgaccgt cacgccgcgc tcgcgcagcc gcagcagcga gtcgggcagg
     6361 tggcccgggc acacgttctc ggcgacggcc tcgacccagt cgatgccggg catgcgctcg
     6421 acggcgtcgg cgatctcagg gcgccacccg atccccgtcc cgagctgagc catggttcct
     6481 cgcgcggtcg ttcctcgtac cgtggcagcc cgctgtaccg cggcgtactc gcgcgccgca
     6541 gcccccgata ccgctgtcgt cccccgtgcg gtcatcctcg ttccccctcc ttgccgctgg
     6601 tcctccccat tggtgcacgt agccgtagtc atgaccgtgc caggtcgggg tgaaccttct
     6661 gatcaggggt ttcagagcta catttgaggt tcgggccgat ccgtgttgac cgtgccggga
     6721 gcgccgggag agggccgtga ggtgccggag acgtcgcccg tggggccggc gggatcgggc
     6781 tgcgggggag cgttgccgcc gggcggcggg gggccggtcg ggctcgcggt ggactttccc
     6841 gcggtgtcgt tcgcgatggc gtcgaagtcg acgtacccgg tgccttcgag catcgtgatg
     6901 tggtcgagga cggtctggtt ggcgtcggac gcgagctgcc ggacaaggga gttgcgggtg
     6961 gtgtcgcgga cctgcgcgat gaggctgaag accttcccgt gcgagacgcg cagcaggttg
     7021 gcgaacttgc gctggtagtc ctcgccgctc gcgtcggtca actcccgcag ccagccctgc
     7081 tgctgggcgt tgggctggtt cggcagctcc acgccgagct gcgaggcgac gccgcgcacc
     7141 cgctggtcga ggtcggtgtg gccgacgatc agatggtcgc ccgcctcctt gacggccttg
     7201 ctcggcgcgc gctccacggc ctgctgtccg gcgggtatct cccagagccc ggcgagccgc
     7261 accttcacga ggaagtcccg gtcggtggcg gacagcgggc cccaacgggt cgacacgctc
     7321 ccggcgttga gattcgcctc gcccgtgccc gagcggtcgg cgtaggacca caccgggaag
     7381 gcgagggctc ccacggtgac gacgagggcg gcgatgatca gggccgtgcc gttgatacgc
     7441 cccatgtgcc tgatgcgctg caaagtactg cctcccgagc cgcatcccgg ccgggggccg
     7501 ggccacttgg tggtaccgga aggtacggga ggtgcggggc cggtgttcag cggcgtgaag
     7561 gttctgtgac gggggtcacg caaggggcct gtacgggcag gcggttcgcc gcctcggcgt
     7621 tgtcagtgcc gtcgactagg gtccggaagg acacgggccg gggttcgaaa gggaacggac
     7681 cgcggcccgg aaggacacga ccgcacacag cacaccgcgg gggcggcccc gcgcgcacgg
     7741 ggaacgggtt gggagtgcgc gggggagccg gaccgggcgg tgcacacggg gaactggagg
     7801 ggccatggcg tccgagaagc cgatcgacct gatccgcctg gagggcgagg acaacagcgt
     7861 cgtcgtcagg atcaccggaa aacgtcccgc cccggggcgc cccggaatcg acgaactcgt
     7921 cggcgagatc cttgtcgaca ccgccttcgt ccaggggacg ctcgccacat cggtgtcccc
     7981 ggaggacctc acgcagtggc gcgagaccct cgacgccctg gacggcggcg acgacagcac
     8041 ctggcgcgag ggcggccgcg cccccgaact cctcgtcgaa ctcgacccgg acggcgagcg
     8101 ggcccacgtc acgatcgccg accacacgat gtccctcacc acggtgacgg ccaccgtcac
     8161 cctcaccgac gagtggttcg acgaggcgta cgaccggttg gacgcgacgc tgcgggcctg
     8221 gccggtggag ggggcgctgc gggggtgagg gacgcggcac acgcgacagg cgctgacgcc
     8281 ccacggtggg acagcgtcga gtactggcgg gcctacctcg cctcgtacag catcgatgtc
     8341 ctgcgggcgt acgagaacga cgactggcag cggatcagcg acgctcagcg ggccgccggt
     8401 tggcttggct gcgcgggtgc gaccgaggaa cagctggcgg ccacggaaga acggctcggt
     8461 acgcgactgc cgcccagcta ccgcgcgttc ctgggcgcgt ccaacggctt cagccacctg
     8521 ggtccgttcc tgtacgagat gagaaccacc aggtcagtgg gctggctgcg cgaggcggag
     8581 ccctcgacct gggagatcat ccgccagggc ggacccgagg aagccgccta catggaccgg
     8641 gtgctgctga tatcggacgt cgccgacgcc cagtactggc tgctcgaccc gggcgacgtc
     8701 tcacccggtg gggaatgggc cgccaacatc tgggccagct ggtacccggg cctgcgcgag
     8761 cgtcgcgcct ccttcgccgc cctcgtcgcc gacgaacggc ggtccttcga acagctgcgg
     8821 gacgacggct gacgaagtct tccggctcac ccaccagcgg ctcaagggcg gcggcgcagt
     8881 gccgggtggt cggcgaccac cgtgcacgag cccggggcga tctccgtgaa gcccgcgtcg
     8941 cggaccaggg ggaggccgct cgtggtcagt tcgggccagc ggggggcggg ggccgtgcgg
     9001 acggagaggg ggaagcccgc ctcgcgccag gccgtgcggt ccggggcgga gaggtcccac
     9061 caggccaact gggcgccgtg gcccgcctgg gccatcgcct tgcccgccga catcgtgatg
     9121 tcggggttca gccagaggac cggggtcgac gggtcggggt cccgaggggg ctccgggtcg
     9181 tccaggtccg tgccggagac ctggaggcgg gccaggtcct tcggccagcc gtccagcggc
     9241 accggcggat acacccggac ctcggccgac ttgcccgtca ccgtgatgcc gggcagcgcc
     9301 tccgcccggc gccactccgc gccacgcgcc ctgcgcacca ccttgcggat ccgggcgtcc
     9361 tgccagtccc gcatcacctg cgcccactcg ccctcgccga gcgcccgctc gtcactcagg
     9421 atcgtcagga ccgcccgcgc cgccgtctcc aacgcgtccg tacgcgccgg gggcgcgccc
     9481 cgctcgatcc gggccaccag gggaagcacg aactgcgggg cctcgtcgcg cggcgtgcgt
     9541 tcgacgcgga aggggctggc cggcggggag taccgggtgg ccggggaggc gggggcgtcg
     9601 agggcggccg gggtgcccgg gtcctcgggg ttcggggtgc ccggggagtt cgcggtgccc
     9661 gcggtggtcg tggtgttcgg gtggccctcg gtgtgggagg tgggctcgga gtctccgggg
     9721 cggggcgcgt tgctggtcac ccgtccagtc tgccagggcg gtgatcgcag gcccggggcg
     9781 gtggcggcgg gcgcggggag ggctgcggcg cgggttcgcg ggggtggtgg cggtggtggt
     9841 ggcttgcggg gtgtgcgcgc gtcgggggtg aggggcggcc gcgtcgggct tgggcggtgg
     9901 ggttctgtgg ggtcggggcc ggtgctcccg ggcgcggccc ggtgttcgca gccccggccc
     9961 ggtgctcctg gcctcggccc ggtgttccag ccccgccctc caccccgccc ccgctcaccc
    10021 cgagcaagcg gtccgctggg cctcctgcca ctcgcagacc gggcacagcg tgctgccccg
    10081 gtacgactcg gggtactccg tcggcttccg gcacagcacg cactccgcga agggcgggcc
    10141 cgccgtcggc cggggggcgg tggaaggggc cggggcgcag tactcgtcgt cgtccgccat
    10201 ggtgggcagc ctagttcggg ccggtggcgg tccgttccgg gcggtgccgc gcgggctcgt
    10261 cggcaccggc aggcccggca ggcccggcag gcccgccagg cccggaatgc cgcgctccct
    10321 ccggagtgcg cgcggccccg atctgctccg agacccggac gaagcggaac ccgcgctcgc
    10381 gcagcttcgg gacgatcgtg cgcagggcgc gttccgtcgc gggggcggcg ctgcgggtgc
    10441 agtgcaggac gacgaccgag ccgggccgca ccccgtcgag cacctgccgg gccaccgcgt
    10501 cggggtccgt ggcgaacgcg tcgccgccca ccacgtccca ctgcacggcg gtcaccccgg
    10561 ccggggcgag cgcgcgcagc gcccgctggt cgtaacagcc gcccgggaag cggaagtacg
    10621 gcaccggccg ctcgacgccc gccttgcgga aggcggcgaa ggcgcgctcg acgtcggcgc
    10681 gcatgcggtg cggggcgacg gtgggcaggc cgtagcagtc gggggtgaag gagtagtggc
    10741 tgtacgagtg gttggcgacc tcgaagagcg ggctgcggcc gatggccctg gcctgcgccg
    10801 ggtactcctc ggcccaccgg cccgtcatga agaacgtcgc cgggaccttg aggcggcgca
    10861 gggtgtcgac cagcgccggg ttgtcgaagc gctcgcccgc cccggcgcgg ggcccctgat
    10921 cggccgtcat gtcggcgtcg aaggtgaggg cgacggtggg cgcgccctgc ttggtgcggg
    10981 gggcgttctt gaagaccggg gtgaggccct gggggcccgg ggcgagggtg ggcggggcgg
    11041 ccttctgggg gttgtggtgg ggagcggggc tgtgggggcg ggtgggggtg gagggcgagg
    11101 cacaggcgct gagggcggtc agtgccgccg cggcgaatgc ggccagggag gcgcgggcgg
    11161 cccgctgccg tgcacgagtg atcatgcggt gaagataact gtgcaaatag gattaatcgg
    11221 gtaggcgagg cccgcccgag ggggtgccgg gccgaagcgc gggggagccg ccgaaggcac
    11281 gcggggcgcc gaagcacgcg ggagccgccg aagcatgcgc gacgccgaag cgcgcggacc
    11341 ccgaggccca cggaaaagcc gaagcacacc gcggaccgcg tgggagacaa tgcgtgcccg
    11401 gcccatgatc gtacgaaagg acgtgcccca tgcccgcctc cctctacaac gtcgccttcg
    11461 gctgcgcgga cgc
//
